Gene Auxilin-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP042_AA protein Get Run
SpurP042_AA_187-357 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Auxilin_pd Subfamily Auxilin 193-357 1.8e-87 284.3 In-house 1-165 (166) alignment
Range on Protein: 193-357
Range on HMM: 1-165/166.0
VASYTKSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRD
||||.|..|||||||||||||||||||.|||||| |||||||||.||...|.|.||||||||.||...||...|.||.| |||  |..||||.| |...|
vasyakndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPGITQSQKRYMEYISGMLS
||||.|.||.||.|.||..||..|.||||.|... ....||||| |.|...|.|||.||....|.
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryleyladlla

subfamily_PTEN_pd Subfamily PTEN 197-356 2.9e-44 146.3 In-house 16-179 (184) alignment
Range on Protein: 197-356
Range on HMM: 16-179/184.0
TKSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNL-SQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKN
 . .||.||||..||.|..|||.||..|.| ..||  |||..|..||...|| |.|.|  .||..||. ..|  . ||.| || ......  |...|.||
dgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkkn

VCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP--PGITQ-SQKRYMEYISGML
| |.||. ||  . ......|  ..|... . .| .|. .|     |.|  ||.||.|| . .|
vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekll

subfamily_Tensin_pd Subfamily Tensin 198-359 7.7e-44 142.4 In-house 8-174 (189) alignment
Range on Protein: 198-359
Range on HMM: 8-174/189.0
KSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVC
| .||..|||.|||..||||||||..|.. . ||  .|...|. .| |||||.. |   |....| | |.| .  | |  |  .|...  |.. ||.|| 
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR-----GPPGITQSQKRYMEYISGMLSPT
|.||  ||   . .||... . .. .. | .|  |..||       . .  ||.||.||.||.||  
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk

subfamily_VSP_pd Subfamily VSP 189-369 4.4e-37 122.1 In-house 20-211 (212) alignment
Range on Protein: 189-369
Range on HMM: 20-211/212.0
VAQTVASYTKS--ELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNL-SQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNM
|..    ||.   .||..|.| ||| ||||. | .| |.| |..|  ||.|.|. ||.|.|| |.|.| .. |.|||. .    .  |.|  | ......
vsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkev

YLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPGI--------TQSQKRYMEYISGMLSPTASIMPHQRVL
  |...|.||| .|||  ||  . ||| ..|    .|.| . ||. |...|   .         | |||||..|.  .       .| ...|
kewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppaktl

PTEN_1 188-357 9.9e-35 115.1 In-house 7-193 (196) alignment
Range on Protein: 188-357
Range on HMM: 7-193/196.0
RVAQTVASYTKSELDISYITSRIIVMS-FPAEG-----LESTYKNGIDDVRSFLETRHSGH-YHVFNLSQR------TYRPAK-FENRVS--DCGFPAKR
|. ..  ....  ||..|||||||.|. .|...      |..|.. ..||...|..... . ..|.||| .      .|.. . |...|.  .....   
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

PPNLVLLYHVCRNMYLWMQRDP-KNVCVIHCMDGKASSATIVSSFLTFCRLfSTVDVSLYMFSVKRGPPG-ITQSQKRYMEYISGMLS
.|.|  | ..|...  |...|| .||...||  |.  |.|.| ..| ...  .|.|  | ..  || | .  . ||.|..|| . .|.
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaella

Pkinase Protein kinase domain 7-139 7e-27 84.1 Pfam-A 70-185 (260) alignment
Range on Protein: 7-139
Range on HMM: 70-185/260.0
QSEYLLLMELCPGGQLVDAINqRHMPLSCDDVLQTFYQACRGVQHMHKQtpPVTHRDIKLENFLIGSKKTLKLCDFGSATGKsyqpdsswsslkRSTLED
..|..|..|...||.| |... .. .|| ... . ..| ..|....|..   ..|||.| ||.|. .|..||..|||.|                .. |.
kdelylvleyveggdlfdllk.kkgklseeeikkialqilegleylHsn..giiHrDLKpeNiLldekgelkiaDFGlakkl............ekssek

EFARHTTPMYRPPEILDlyENFPINHAMDVWSA
   .  |. |..||.|   ..  . ...||||.
lttlvgtreYmAPEvll..kakeytkkvDvWsl

0036282 (Phosphotyrosine protein) phosphatases II 200-356 6.4e-26 86.5 In-house 9-169 (174) alignment
Range on Protein: 200-356
Range on HMM: 9-169/174.0
ELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQ-RTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCV
 ||.||||.|.|....|.. .|  ...|| .| ..|| .. |.| ..|.   . . . ..  .. ....|   .|.|  |..... .. ....||.....
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

IHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR---GPPGITQSQKRYMEYISGML
.||. |.  ..|.|  .|  ..|.....  |...  .|   ..  .|.|| |.  |.. .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 365-499 1.1e-23 74.8 Pfam-A 2-127 (134) alignment
Range on Protein: 365-499
Range on HMM: 2-127/134.0
HQRVLLIKSLRLTPVPLYnKMRSGCRPFCEVFHDEERILSTSQEYERMRGFEVEDASAFIDLNIPVCGDVMVVVYHARSTfggkvqgK----VtglkMFQ
... | .||..| ..| . |.|.||.|...|.  .. . .....|. ..  . ...   .. ..||.|||.| ..| .|.       .         .|.
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsk.......lpkkek....ifr

FQFNTGFIEPGTKEISFNRYELDFFELDKfAEHFHASLD
..||| |||  .. . ....||| .  ||  ..|.    
vwFNTsFieknqnvltlpkneLDkalkdk.dkkfsknfk

0038934 (Phosphotyrosine protein) phosphatases II 204-350 4.4e-23 77.4 In-house 14-170 (194) alignment
Range on Protein: 204-350
Range on HMM: 14-170/194.0
SYITSRIIVMSFPAEG-----LESTYKNGIDDVRSFLETRHSGHYHVFNLS--QRTYRPAKFEN---RVSDCGFPAK-RPPNLVLLYHVCRNMYLWMQRD
..|| |.|....|..|     .|..|.....|. ..|.... ....| .|.   |.| | .||.   .. .. || .  .|.| .|.. .. .. ....|
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned

PKNVCVIHCMDGKASSATIVSSFLTFCRLFsTVDVSLYMFSVKRGPPGITQSQKRYME
|..|...||. |.  ..|.| ..|  .. . ... ....|. ||..  ..|.. ... 
pggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipnqdyleall

Pkinase_Tyr Protein tyrosine kinase 8-138 8.8e-17 51.0 Pfam-A 74-190 (259) alignment
Range on Protein: 8-138
Range on HMM: 74-190/259.0
SEYLLLMELCPGGQLVDAINQR-HMPLSCDDVLQTFYQACRGVQHMHKQTppVTHRDIKLENFLIGSKKTLKLCDFGSATGKsyqpdsswssLKRSTLED
...|...|...||.| . .... . .|. .|.|.  .| ..|........  . |||.   | |. ..|. |..||| |              |... ..
epllivteyvegGdLlkfLrkkekekltledllsfalqiAkGmeyLeskk..lvHrdLaarNvLleenkvvkisDfGLardi..........ekddyykk

EFARHTTPMYRPPEILDLYEnfpINHAMDVWS
.  ...   . .||.|.  .   .... ||||
kekaklpvkWmapEslkekk...ftsksDvWs

0041856 (Phosphotyrosine protein) phosphatases II 201-352 1.4e-15 52.8 In-house 17-166 (182) alignment
Range on Protein: 201-352
Range on HMM: 17-166/182.0
LDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHY-HVFNLSQRTYRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLwmqrdPKNV
.|..||. .....|.||   . |. . ...| .||.. .. .. .. ||. . | | ..|.   .. . ..|   .|.|  |.. .. ..      ....
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggp

CVIHCMDGKASSATIVSSFLTFCRlFSTVDVSLYMFSVKRGPPGITQSQKRYMEYI
...||. |.  ..|.|  .|  ..   ...  . ..  .|    || .| ..  ..
vlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpgmvitpnqyfflqla

0046846 (Phosphotyrosine protein) phosphatases II 198-351 9.9e-15 50.2 In-house 7-167 (176) alignment
Range on Protein: 198-351
Range on HMM: 7-167/176.0
KSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETrhsGHYHVFNLSQRT-----------YRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMY
  .||..||. ..|..|.|. . ......  |... ..|    |...|.|| ...            .  |.. ..  ...|   .|.| ||..... ..
gldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefir

LWMQRDpkNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRG-PPGITQSQKRYMEY
 . ...  .. ..||. |.  ..|.|  .|  .. . .|.  |...  .|      |..| |. ..
ealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflye

0039614 (Phosphotyrosine protein) phosphatases II 197-331 1e-14 50.2 In-house 79-263 (297) alignment
Range on Protein: 197-331
Range on HMM: 79-263/297.0
TKSELDISYI-----------TSRIIVMSFPAEG-----LESTYKNGIDDVR----------------------------SFLETRHSGHYHVFNLSQRT
 .. || .||           | ..|....| ..     ..  ...|.  .                              .|.. | ..|.|..|. . 
dgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn

YRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL----YM
. . .. ...   |.|   .| .| ||..... .  ..... .......||..|.  ..|..  .| ...| .. .|..     .
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke

0043147 (Phosphotyrosine protein) phosphatases II 200-356 2e-14 49.2 In-house 12-160 (172) alignment
Range on Protein: 200-356
Range on HMM: 12-160/172.0
ELDISYITSRIIVMSFPaeglestYKNGIDDVRSFLETRHSGHyhVFNLSQRTYRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNV
 ||..||. |.|.. .|       . | ..|.. .| ... .|  ..|| ...| | ..|    ..  ...|   .|.| ||..... .. .....|...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

CVIHCMDGKASSATIVSSFLTFCRLfsTVDVSLYMFSVKRGPPGITQSQKRYMEYISGML
...||. |.  ..|.|  .|  ..|  ...  . ..  ||.    ..|| |.  | . .|
vlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekRpgavqnpsqyrflyyfekll

0051082 (Phosphotyrosine protein) phosphatases II 201-348 5.6e-14 47.5 In-house 6-143 (151) alignment
Range on Protein: 201-348
Range on HMM: 6-143/151.0
LDISYITSRIIVMSFPAEglestykngidDVRSFLetRHSGHYHVFNLSQRT---YRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPK
...||.|........| .           |.  .|  .. |.....|| . .   | |  ...   .| .. ..   .|.| |... ....  .......
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVCVIHCMDGKASSATIVSSFLTFCRlfSTVDVSLYMFSVKRGpPGITQSQKRY
.....||. ||  ..|.|  .|  ..   ...  | ..  ||.   .. .| ..
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.gvvqpnqqfl

0042113 (Phosphotyrosine protein) phosphatases II 197-346 2.1e-12 42.5 In-house 31-232 (245) alignment
Range on Protein: 197-346
Range on HMM: 31-232/245.0
TKSELDISYI----------TSRIIVMSFPAEGLES-----TYKNGIDDVR------------------------------SFLETRHSGHYHVFNLSQR
....|| .||          | ..|....|...         ...||  .                                .|.. | ..|.|..|.  
dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevt

--TYRPAKFENRVSDCGFPAKRPPN-LVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVS----LYMFSVKRGPPGITQS
   . . .. ...   ..|   .|. | ||  ... .  ....|.......||..|.  ..|..  .| ...| .. .||    ....  .|.    |.|
nlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtps

QK
| 
qy

0037934 (Phosphotyrosine protein) phosphatases II 201-350 2.2e-12 42.5 In-house 37-235 (243) alignment
Range on Protein: 201-350
Range on HMM: 37-235/243.0
LDISYITSRIIVMSFPAEGLEST---------YKNGIDDVR----------------------------SFLETRHSGHYHVFNLSQRT---YRPAKFEN
.. .|.| |.|....| ..             ...||. .                              .|...| ..|.|..|. .    . . ..  
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

RVSDCGFPAKRPPN--------LVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP-PGITQSQKRYME
..   ..|   .|.        |  .. ...........|.......||. |.  ..|..  .|   .|  ...  . ..  .|.     |.|| |.  
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

0043336 (Phosphotyrosine protein) phosphatases II 195-331 3.2e-12 42.0 In-house 65-251 (278) alignment
Range on Protein: 195-331
Range on HMM: 65-251/278.0
SYTKSELDISYI----------TSRIIVMSFPAEGLESTYKNGIDDVR----------------------------------SFLETRHSGHYHVFNLSQ
| ....|| .||          . ..|....| .. .  . . . . .                                   .|.. | ..|.|..|  
sllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlev

R--TYRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLY----M
    . . .. ...   |.|    | .| || . .. .  ... |.... ..||..|.  ..|..  .| ...| ..  |.|.    .
tnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke

0045450 (Phosphotyrosine protein) phosphatases II 204-344 8.5e-12 40.9 In-house 108-291 (307) alignment
Range on Protein: 204-344
Range on HMM: 108-291/307.0
SYI----------------------------------TSRIIVMSFPAEGLESTYKNgidDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGF--
 .|                                  ....... .| || | ||.|   ..  .|.. | ..|.|..|    ... ... .|    .  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

-PAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRL--------FSTVDVSLYMFSVKrgpPGI--TQS
 |    | ..  | . .. .  ..... .......||..|.  ..|..  .|  ..|        ..  ..  .. . .   ||.  ...
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpe

0049260 (Phosphotyrosine protein) phosphatases II 211-355 1.8e-11 39.5 In-house 5-148 (152) alignment
Range on Protein: 211-355
Range on HMM: 5-148/152.0
IVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRT-YRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSA
. |.|.. . . .. | ..|.  .| . . ... . .  .   .   ..  ..  . .|   .|.|  |   .  .  ....|.......||. |.  ..
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TIVSSFLTFcrLFSTVDVSLYMFSVKRGPPGITQSQKRYMEYISGM
|.|  .|    |  ...  . ..  ||    ....| |.  . ...
tlvaaylml..lgvsleeavalvrekRpgavpnpgqlrflyefekl

0048076 (Phosphotyrosine protein) phosphatases II 215-352 3.5e-11 38.5 In-house 3-138 (145) alignment
Range on Protein: 215-352
Range on HMM: 3-138/145.0
FPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNL-VLLYHVCRNMYLWMQRDpkNVCVIHCMDGKASSATIVS
.|.| |.. | ... ..... . .. |...|.||.  .. . ..  ..  ...|   .|.|  ||..... .  .....  .....||. |.  ..|.| 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

SFLTFCRLFSTVDVsLYMFSVKRGPPGITQSQKRYMEYI
 .| ... .|  .. | ..  .|    ....| |.... 
aylmlllgvsleea.lelvrsqrpgavpnpgqlrflyef

0048179 (Phosphotyrosine protein) phosphatases II 215-352 4.8e-11 38.1 In-house 3-140 (144) alignment
Range on Protein: 215-352
Range on HMM: 3-140/144.0
FPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFEN--RVSDCGFPAKRPPNL-VLLYHVCRNMYLWMQRDpkNVCVIHCMDGKASSATI
.|.| |.. | ... ..... . .. |...|.||.   . .    .  ..  ...|   .|.|  ||..... .  .....  .....||. |.  ..|.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VSSFLTFCRLFStVDVSLYMFSVKRGPPGITQSQKRYMEYI
|  .| ... .| ..  |...  .|    ....| |.... 
vaaylmkklgls.leealalvrsrrpgavpnpgqlrfLley

0044763 (Phosphotyrosine protein) phosphatases II 201-353 2.3e-10 35.9 In-house 21-167 (178) alignment
Range on Protein: 201-353
Range on HMM: 21-167/178.0
LDISYITSRIIVMSFPAeglestykngiDDVRSFLetRHSGHYHVFNLSQ---------RTYRPAKFENRVSDCGFPAKRPPN-LVLLYHVCRNMYLWMQ
...|.|. .....|.|.            | . .|  .  |  |. ||..           | | ... ..  ...|   .|. |  .. ... .  ...
inaseilpglylgslpp...........addlell..kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald

RDPkNVCVIHCMDGKASSATIVSSFLTFCRLFsTVDVSLYMFSVKRGpPGITQSQKRYMEYIS
... .....||. |.  |.|.|  .|  .. . ...  . ..  .|    ....| |..... 
ekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefe

0040439 (Phosphotyrosine protein) phosphatases II 200-330 9e-10 34.1 In-house 46-215 (249) alignment
Range on Protein: 200-330
Range on HMM: 46-215/249.0
ELDISYITSRIIVMSFPAEGLESTYKNGIDDVR-----------------------------------SFLETRHSGHYHVFNLSQRT-YRPAKFENRVS
 .| .||. |.|....| ..  . . . . . .                                    .|.. ....|.|..|     | . ... .. 
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

DC-GFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLY
 . ..|    | ..  |   .. .  ..... .......||..|.  ..|..  .| ...|  . .|.|.
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdle

0040438 (Phosphotyrosine protein) phosphatases II 197-331 1.1e-09 33.5 In-house 65-250 (317) alignment
Range on Protein: 197-331
Range on HMM: 65-250/317.0
TKSELDISYI----------TSRIIVMSFPAEG-----LESTYKNGIDDVRSFLETR------------------------------HSGHYHVFNLSQR
... || .||          . ..|....| ..     ..  ...|.  . .. |.                               . .......|   
lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleve

T-YRPAKFENRVSDCGF-PAKRPP-NLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL----YM
  . . ......  . . |   .| .. || . .. .  ... ||......||..|.  ..|..  .| ...|  . .|..    ..
dlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavke

0045098 (Phosphotyrosine protein) phosphatases II 200-350 1.5e-09 33.1 In-house 6-265 (278) alignment
Range on Protein: 200-350
Range on HMM: 6-265/278.0
ELDISYITSRIIVMSFPAEGLESTYKNGID----------------------------------------------------------------------
.||..... .......| | ... | ...|                                                                      
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

---------------------DVRSFlETRHSGHYHVFNLSQRTYRPAKFENRVSDC-GFPAKRPPNLV---LLYHVCRNMYLWMQ------------RD
                     ..  . .. .  ...| ||. . .   ... .. .. ..|   .|.|     . .... .  ...             |
caqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

PKNVCVIHCMDGKASSATIVSSFLTFCR---LFSTVDVSLYMFSVKRGPPGITQSQKRYME
.......||. |.  ..|.|  .|  ..    ..  ..  .. | ..|    ...| |...
sggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly

0046845 (Phosphotyrosine protein) phosphatases II 194-344 2.4e-09 32.5 In-house 62-259 (284) alignment
Range on Protein: 194-344
Range on HMM: 62-259/284.0
ASYTKSE-LDISYITSRIIVMSFPAEG-----------------------------LESTYKNGIDDVRSF-------LETRHSGHYHVFNLSQRTYRPA
||| .   ||..||. ..|....| ..                               . | . ...|  .       |.. . ..| |..|. . . . 
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgyt

KFENRVSDCGF----PAKRPPNLVLLYHVCRNMYLWMQR-DPKNVCVIHCMDGKASSATIVSSFLTFCRLFS-----TVDVSLYMFSVKRGPPGITQS
... .|    .      . ||..  | . .| .  .... ..... |.||..|.  ..|..   | ...|       .|||  ..  ...  ||  |.
gesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt

0049772 (Phosphotyrosine protein) phosphatases II 205-351 2.7e-08 29.4 In-house 118-272 (314) alignment
Range on Protein: 205-351
Range on HMM: 118-272/314.0
YITSRIIVM---------------------SFPAEGLEstyknGIDDVRSFLETRhsghyhvfnlsQRTYRPAKFENRVSDC---GFPAKRPPNLVLLYH
 . .|.|||                       .. |.      .. ... . . .           ...| | .||...       .|   .| |  ...
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfde

VCRNMYLWmqrDPKNVCVIHCMDGKASSAT-IVSSFLTFCRLFsTVDVSLYMFSVKRGpP----GITQSQKRYMEY
... .  .   |.... ..||..||  ..| .|  .|  .. . ...  | ..  ||       |  .....| ..
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefi

DnaJ DnaJ domain 1153-1197 6e-08 21.6 Pfam-A 13-55 (64) alignment
Range on Protein: 1153-1197
Range on HMM: 13-55/64.0
EHNQVKKWYRKAVLSAHPDKQVGTPneELAKLIFMELSDAWSAFE
  ...|| ||| .|  ||||  . .  | |.  | |...|... .
sdeeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevLs

0051299 (Phosphotyrosine protein) phosphatases II 234-344 2.1e-06 22.9 In-house 153-271 (288) alignment
Range on Protein: 234-344
Range on HMM: 153-271/288.0
FLETRHSGHYHVFNLSQRTYR---PAKFENRVSDCGF----PAKRPPNLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRL--FST
.|.. . ..| |..|  . ..   . ... .|    .        |... || . .| .. ... ......|.||..|.  ..|..  .| ...|    .
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

VDVSLYMFSVKRGPPGITQS
|||  ..  ...  ||. |.
vdvleavkrlreqRpgmvqt

0047943 (Phosphotyrosine protein) phosphatases II 234-330 2.8e-06 22.5 In-house 141-241 (273) alignment
Range on Protein: 234-330
Range on HMM: 141-241/273.0
FLETRHSGHYHVFNLSQRT--YRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL
.|.. . ..| |..|  .   .   .. . .   |.|    | .|  | . .. .  ... .  ... |.||..|.  ..|..  .| ...|  .  |..
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

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