Gene PTEN-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP044_AA protein Get Run
SpurP044_AA_0-152 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 1-151 2.5e-72 237.7 In-house 32-182 (184) alignment 
Range on Protein: 1-151
Range on HMM: 32-182/184.0
MGFPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVM
||.|||.||..|||..|.|||||...|.||||.|||.|||.||...||.|||.|||||||||..||.....||. .||.|||.||...|||||||||||.
mgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvl

ICALLLHQGRCLTAAESMEYYGKIRTTDGKGVTIPSQRRYVQYYGELVKRN
|.|.||... . .| |..|.. ..||...||||||||||||.|| .|....
ivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
subfamily_VSP_pd Subfamily VSP 1-150 1.9e-52 172.3 In-house 46-200 (212) alignment 
Range on Protein: 1-150
Range on HMM: 46-200/212.0
MGFPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVM
| ||.   . .||| .. |..||.  |.|||||.||||||.|| . |..|| .   |||| |..| .  |...| .||..|..|| ||||| |||||| .
msfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGti

ICALLLHQGRCLTAAESMEYYGKIRTTDG-----KGVTIPSQRRYVQYYGELVKR
.|||||. . . || ||..|.|. ||  .     .||  |||.|||.|. .....
vcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktk
PTEN_1 3-149 3e-41 136.4 In-house 35-193 (196) alignment 
Range on Protein: 3-149
Range on HMM: 35-193/196.0
FPAES-----LERMYRNDMEHVVKFLNSHHQDH-YKVYNLCSERN-----YDTS-RFDHRVA--HYPFDDHNPPRIELIRPFCEDVMQWLAEDK-DNVAA
.|...      |..||. ...|...|.. ..|. . |.||..|..     || . .|...|   |.|..||..| .. .  .|.....|| .|.  ||..
apsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

IHCKAGKGRTGVMICALLLHQGRcLTAAESMEYYGKIRTTDGKGvtIPSQRRYVQYYGELVK
.|||||.||.|....|.|.. |. ||| | .|.. . |.  ..   .|||.|...|. || .
VHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella
0036282 (Phosphotyrosine protein) phosphatases II 1-148 1.5e-39 130.8 In-house 22-169 (174) alignment 
Range on Protein: 1-148
Range on HMM: 22-169/174.0
MGFPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVM
...|.. .| ..... ..|| .|.... ..||..|...|. .| .|..... ..|..||..| .. .. |.. | ..|.||.... ..||.||.||||..
gqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtl

ICALLLHQGRCLTAAESMEYYGKIRTTDGKGVTIPSQRRYVQYYGELV
..|.|...| . .. . .... ..|.  ...|..|||.|...|.. |.
vaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_Tensin_pd Subfamily Tensin 1-161 3.1e-36 117.7 In-house 23-184 (189) alignment 
Range on Protein: 1-161
Range on HMM: 23-184/189.0
MGFPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLcSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVM
. ||||.||. ||.....|.|.|.|.|.|.| |.|| ||..|| |.....|  . . |.  | .| .   |... .|| .| .||...||| ||||.||.
lsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvv

ICALLLHQGRCLTAAESMEYYGKIRTTD--GKGVTIPSQRRYVQYYGELVKRNTLYKTQTVLL
. | . ..  . .| .... .   | .|   .|.| |||||||.|. .|.. .   ... ..|
vsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplfl
subfamily_Auxilin_pd Subfamily Auxilin 1-149 3.6e-34 110.9 In-house 21-165 (166) alignment 
Range on Protein: 1-149
Range on HMM: 21-165/166.0
MGFPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLcSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVM
| |||| .|  |.|... | .||.|.|...|.|||| |.|.|.|.... || .. .  .. | .| .   | .. .|| .|. ||  .||| |.  ..|.
msfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvvhckDGraasavl

ICALLLHQGRCLTAAESMEYYGKIRTTDGkgvTIPSQRRYVQYYGELVK
..|||..     .. .... .   |.. |     ||..||..| ..|..
vsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladlla
0038934 (Phosphotyrosine protein) phosphatases II 1-152 7.1e-34 112.5 In-house 23-174 (194) alignment 
Range on Protein: 1-152
Range on HMM: 23-174/194.0
MGFPAES-----LERMYRNDMEHVVKFLNSHHQDHYKVYNLC-SERNYDTSRFDH---RVAHYPFDDH-NPPRIELIRPFCEDVMQWLAEDKDNVAAIHC
...|...     .| .||...|..|..|.........|..|. .|| ||...|     .. ..|| |. ..| .|... |.. | ..|.||...| |.||
fkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHC

KAGKGRTGVMICALLLHQGRClTAAESMEYYGKIRttdgkgvtiPSQRRYVQYYGELVKRNT
|||.||||....| |..  .. .| |.....  .|         |.. ....|. .|.||  
kaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdyleallkryk
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 154-328 3.8e-33 105.5 Pfam-A 1-133 (134) alignment 
Range on Protein: 154-328
Range on HMM: 1-133/134.0
YKTQTVLLKRVQLYTIPMM-SSGTCCPFFTVHQHKVKI-HTQEAVKGVKKG-LSCVEFELPHALPIRDDVKIEFYHKSGLLKMDKRlMFHMWFNTYFIVH
|. ... ||.. |..||.. ..|.| |...| ..|.|. ....  |  ..    .. ...|. ||...||..||.||.  |..... .|..||||.|| .
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkek.ifrvwFNTsFiek

piqpdkdyfgqarshsrptstvscpspdqarapfaedemlnggEEFVLELHKDEIDKANKDKtNKVFSPNLKVKLFFA
                                           .. ||.| |.|.|||.||| .| ||.| ||.| | 
...........................................nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe
0049260 (Phosphotyrosine protein) phosphatases II 5-148 3.9e-33 109.7 In-house 11-149 (152) alignment 
Range on Protein: 5-148
Range on HMM: 11-149/152.0
AESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICAL
.   . ...|........| ... ... ... ..|....   .  .. |.|..||..| .. . .|. .....||.||... ..||.||.||||....|.
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LLHqgrclTAAESMEYYGKIRTTDGKGVTIPSQRRYVQYYGELV
|..        .  |..  .|.   ..|. |.|.|..... .|.
lml.....lgvsleeavalvrekRpgavpnpgqlrflyefekll
0046846 (Phosphotyrosine protein) phosphatases II 5-147 1.1e-30 102.1 In-house 37-171 (176) alignment 
Range on Protein: 5-147
Range on HMM: 37-171/176.0
AESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSErnydTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDkdNVAAIHCKAGKGRTGVMICAL
|. ||...... ..|| ... .. ...|..|...|      ...... |.|..||..| .||.  ..| . ..| |.  .. ..||.||.||||....|.
adflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaay

LLHQGRCLTAAESMEYYGKIRTTdgKGVTIPSQRRYVQYYGEL
||. ...|.. | .... ..|    . |. |.|.|.....  |
llelekglsveealalvreqRpl..gavqtpeQyrflyefell
0037934 (Phosphotyrosine protein) phosphatases II 6-144 7.3e-30 99.7 In-house 63-237 (243) alignment 
Range on Protein: 6-144
Range on HMM: 63-237/243.0
ESLERMYRNDMEHVV----------------------------KFLNSHHQDHYKVYNLCSER--NYDTSRFDHRVAHYPFDDHNPPR-IELIRPFCEDV
. .. ..... ...|                            ..|...| |.|.|..|. |.   .| .|..... ..|. ||..|  .| .  |...|
sfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldev

MQWLAE-------DKDNVAAIHCKAGKGRTGVMICALLLHQGRCLTAAESMEYYGKIRTTdgKGVTIPSQRRYVQYY
 ... |       |.... ..||.||.||||..|.|.|...  .... | .... . |    |.|..|||.|.....
refieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg..kavqtpsqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 2-144 4.7e-29 97.2 In-house 107-284 (297) alignment 
Range on Protein: 2-144
Range on HMM: 107-284/297.0
GFPAES-----LERMYRNDMEHVV----------------------------KFLNSHHQDHYKVYNLCSERnYDTSRFDHRVAHYPFDDHNPP-RIELI
..| ..     .. ..... ...|                            ..|. .| |.|.|..|. .. .. ||. ... .... ||..|  .||.
qgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslell

RPFCEDVMQWLAED-KDNVAAIHCKAGKGRTGVMICALLLH----QGRCLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
  |.| |...|||. |... ..||.||.||||..|.|.|..     ...... | .... . |   ...|..||| |.....
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR...pgavqtpsqyrflyda
0043147 (Phosphotyrosine protein) phosphatases II 11-148 4.7e-29 96.7 In-house 28-160 (172) alignment 
Range on Protein: 11-148
Range on HMM: 28-160/172.0
MYRNDMEHVVKFLNSHHQDHykVYNLCSE--RNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHq
..||........| ... .|  ..||...    .. .|.. .. ..|..||..| .||.. |.| . ..||...... ..||.||.||||....|.|.. 
plrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.

gRCLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYYGELV
 ..|.. | .... . |   ...|..|||.|...|. .|.
.lglsleeavalvrekR...pgavqnpsqyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 11-144 1.9e-27 91.7 In-house 72-238 (245) alignment 
Range on Protein: 11-144
Range on HMM: 72-238/245.0
MYRNDMEHVV------------------------------KFLNSHHQDHYKVYNLCSER-NYDTSRFDHRVAHYPFDDHNPPR-IELIRPFCEDVMQWL
..... ...|                              ..|. .| |.|.|..|. ..  .| ||..... ..|..||..|  .||.  |.| | ..|
lwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkal

AEDKDNVAAIHCKAGKGRTGVMICALLLH----QGRCLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
|||.... ..||.||.||||..|.|.|..      ..... | .... . |   .. |..||| |.....
aedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR...pgavqtpsqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 18-144 1.2e-26 89.3 In-house 144-272 (278) alignment 
Range on Protein: 18-144
Range on HMM: 144-272/278.0
HVVKFLNSHHQDHYKVYNLCSER-NYDTSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLAeDKDNVAAIHCKAGKGRTGVMICALLLH----QGRC
 .|..|. .|.|.|.|..|. ..  .. ||. ... .... ||. |  ..|.  |...|...|. |.... ..||.||.||||..|...||.     ...
ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekegg

LTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
... | .... . |   .. |. ||| |.. ..
vdleeavkelreqR...pgavqtpsqyrflyea
0048076 (Phosphotyrosine protein) phosphatases II 3-145 3.3e-26 87.1 In-house 3-139 (145) alignment 
Range on Protein: 3-145
Range on HMM: 3-139/145.0
FPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTsRFDHRVAHYPFDDHNPPRI-ELIRPFCEDVMQWLAEDkdNVAAIHCKAGKGRTGVMI
.|.| |...|.... ..... . .. ... |.||.||... . |.. .. ..|..||..| . ||.. |.| . ..|.|.  .. ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CALLLHQGRcLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYYG
.| |... . ... | .|.. . |    ..|. |.|.|..... 
aaylmlllg.vsleealelvrsqr...pgavpnpgqlrflyefe
0051082 (Phosphotyrosine protein) phosphatases II 16-144 3.9e-26 86.8 In-house 22-147 (151) alignment 
Range on Protein: 16-144
Range on HMM: 22-147/151.0
MEHVVKFLnsHHQDHYKVYNLCS--ERNYDTSRFDH---RVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGr
.......|  ...... ..||.|  ||.|.....     .| |.|..|. .| ..|. ... .....|...|... ..||.|||||||......|...| 
ladflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.

cLTAAESMEYYGKIRTtdgkGVTIPSQRRYVQYY
 ....| .|.| ..|.    ||..|.| ...|..
.vsleealeeyrlkrp....gvvqpnqqflfqlf
0045450 (Phosphotyrosine protein) phosphatases II 2-144 4e-26 87.9 In-house 152-299 (307) alignment 
Range on Protein: 2-144
Range on HMM: 152-299/307.0
GFPAESLERMYRNdmeHVVKFLNSHHQDHYKVYNLCSERNyDTSRFDHRVAHYPF---DDHNPP-RIELIRPFCEDVMQWLAED-KDNVAAIHCKAGKGR
 .| |. | .|.|    .|..|. .|.|.|.|..|. ... | . . ..| |...    ||. |  .| .  |.| |...|.|. |... ..||.||.||
ywPdegeeltygn...ftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

TGVMICALLLHQGRC-------LTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
||..|.|.|. ...        ... | .... . |   ...|. |.| |.....
tGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 17-148 5.8e-26 87.4 In-house 153-277 (314) alignment 
Range on Protein: 17-148
Range on HMM: 153-277/314.0
EHVvKFLNSHHQDHYKvynlcsERNYDTSRFDHRVAHY---PFDDHNPPRIELIRPFCEDVMQWlaeDKDNVAAIHCKAGKGRTGV-MICALLLHQGRCl
..   ... ......|      |. || ..| ... .|   |..|...| .| .. |.| . ..   ||... ..||||||||||. ...|.|... .. 
gng.neptaadlellk......eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.

TAAESMEYYGKIRTTDGKGVTIPSQRRYVQYYGELV
...| .|.. ..|.   . ..|.....|....  | 
sleealedvrlkRpinpnpgfieqleqyefileall
0041856 (Phosphotyrosine protein) phosphatases II 2-144 1.5e-25 85.3 In-house 30-166 (182) alignment 
Range on Protein: 2-144
Range on HMM: 30-166/182.0
GFPAESLERMYRNDMEHVVKFLNSHHQDHYK-VYNLCsERNYDTSRFDH---RVAHYPFDDHNPPRIELIRPFCEDVMQwlaedKDNVAAIHCKAGKGRT
..||   . .... ...| .||.  .. ... . ||. |..|. ... .   .. ..|..||..| .. .  |.|.| .     .... ..||.||.|||
slpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRt

GVMICALLLHQGRcLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
|....| |... . ... | .... . |    ..|..|.| ...|..
gtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqla
0048179 (Phosphotyrosine protein) phosphatases II 3-146 2e-25 84.6 In-house 3-142 (144) alignment 
Range on Protein: 3-146
Range on HMM: 3-142/144.0
FPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTS-RFDHRVAHYPFDDHNPPRI-ELIRPFCEDVMQWLAedKDNVAAIHCKAGKGRTGVM
.|.| |...|.... ..... . ...... |.||..|. ..   |. ... |.|..||..| . ||.. |.| . ..|.  .... ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

ICALLLHQGRcLTAAESMEYYGKIRTtdgKGVTIPSQRRYVQYYGE
..| |..  . |.. | .... ..|     .|. |.|.|....|..
vaaylmkklg.lsleealalvrsrrp...gavpnpgqlrfLleyek
0040438 (Phosphotyrosine protein) phosphatases II 11-144 5.1e-25 83.8 In-house 106-271 (317) alignment 
Range on Protein: 11-144
Range on HMM: 106-271/317.0
MYRNDMEHVV------------------------------KFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPF-DDHNPP-RIELIRPFCEDVMQWL
..... ...|                              ..|. .. .......|. | ..|   .  .. ||.. .||..|  ..|.  |.| | ..|
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

AeDKDNVAAIHCKAGKGRTGVMICALLLH----QGRCLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
. |.... ..||.||.||||..|.|.|..    ....... | .... . |   ...|. |.| |.. ..
e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR...pgavqtpeqyrflyda
0040439 (Phosphotyrosine protein) phosphatases II 18-144 2.2e-24 81.9 In-house 111-241 (249) alignment 
Range on Protein: 18-144
Range on HMM: 111-241/249.0
HVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHY-PFDDHNPP-RIELIRPFCEDVMQWLAED-KDNVAAIHCKAGKGRTGVMICALLLH----QGR
 .|..|. .. |.|.|..|. ...|| . .  .. .| .. ||. |  .| .  |.| |...|.|. |... ..||.||.||||..|.|.|..      .
ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekel

CLTAAESMEYYGKIRttdGKGVTIPSQRRYVQYY
.... | .... . |   ...|. |.| |.....
gvdleeavkllrsqR...pgavqnpeqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 18-143 7.1e-23 76.9 In-house 137-266 (273) alignment 
Range on Protein: 18-143
Range on HMM: 137-266/273.0
HVVKFLNSHHQDHYKVYNLCSER-NYDTSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLAED-KDNVAAIHCKAGKGRTGVMICALLLH----QGR
  |..|. .. |.|.|..|. .. ... ||. . . .... ||. |  .| .  |.|.|...|... .... ..||.||.||||..|...||.     ..
ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg

CLTAAESMEYYGKIRTTdgkGVTIPSQRRYVQY
.... | . .. . |     .|. |.|.|.. .
gvdvleavkllrsqRpg...mvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 18-143 2.2e-22 75.3 In-house 149-280 (288) alignment 
Range on Protein: 18-143
Range on HMM: 149-280/288.0
HVVKFLNSHHQDHYKVYNLCSERN--YDTSRFDHRVAHYPF----DDHNPPRIELIRPFCEDVMQWLAeDKDNVAAIHCKAGKGRTGVMICALLL-HQGR
 .|..|. ...|.|.|..|. ...  .| . . ..| |. .    |.. |. .||.  |...|...|| ..... ..||.||.||||..|...|| .| .
itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqle

CLTAAESMEYYGKIRTTDGKGVTIPSQRRYVQY
.    . .|.. ..|.     |. |.| |.| .
keggvdvleavkrlreqRpgmvqtpeqyrfvye
0045098 (Phosphotyrosine protein) phosphatases II 12-147 3e-22 74.7 In-house 85-270 (278) alignment 
Range on Protein: 12-147
Range on HMM: 85-270/278.0
YRNDMEHVVKFLN-----------------------------------SHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIE---LIRPFCED
. .. ...|   .                                     .  ...|.||..||....||. . .  .|..||..|  .    .  ..| 
welgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellef

VMQWLA------------EDKDNVAAIHCKAGKGRTGVMICALLLHQG--RCLTAAESMEYYGKIRttdGK-GVTIPSQRRYVQYYGEL
. ..|.            .|.... ..||.||.||||....| |. .   . ... |  ... . |   .   |....| |.. ..  .
irealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR...pglavqnleqyrflyeflle
0046845 (Phosphotyrosine protein) phosphatases II 11-143 2.5e-20 68.5 In-house 121-268 (284) alignment 
Range on Protein: 11-143
Range on HMM: 121-268/284.0
MYRNDMEHVVKF-------LNSHHQDHYKVYNLCSERN--YDTSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLAE-DKDNVAAIHCKAGKGRTGV
 |......|...       |. ...|.|.|..|. ...   . ||. .   . .. ||. |  .| .  |...| ..| . ..... ..||.||.||||.
qYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGt

MICALLLHQGR-------CLTAAESMEYYGKIRttdGKGVTIPSQRRYVQY
.|.. ||..         .... | . .. . |      |. ..| |.| .
fialdllleqlekeglllgvdvleavkrlreqR...pgmvqtleqyrfvye
0044763 (Phosphotyrosine protein) phosphatases II 5-147 9.5e-20 66.4 In-house 38-169 (178) alignment 
Range on Protein: 5-147
Range on HMM: 38-169/178.0
AESLERMYRNDMEHVVKFLNSHHQDHYKvynlcsERNYDTSRFDHRVAHYPFDDHNPPR-IELIRPFCEDVMQWLAeDKDNVAAIHCKAGKGRTGVMICA
|. || .....  |.| . .  .  ..|      .  |. .... .. |.|..||..|  .| .. |.| . ..|. .|... ..||.||.||.|....|
addlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaa

LLLHQGRClTAAESMEYYGKIRttdGkGVTIPSQRRYVQYYGEL
 |... .. .. | .|.. . |     .|. |.|.|..... . 
ylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelr
0036941 (Phosphotyrosine protein) phosphatases II 10-145 5.6e-17 57.4 In-house 131-273 (297) alignment 
Range on Protein: 10-145
Range on HMM: 131-273/297.0
RMYRNDMehVVKFLNSHH--QDHYKVYNLCSER-NYDTSRFDHRVAHYPFDDHNPPR-IELIRPFCEDVMQWLAED-KDNVAAIHCKAGKGRTGVMICAL
 .. .|.  .|..|. ..   |.|....|. .  ... ||. .   .   .||..|  .. .  |.| | ..|..  ....  .||.||.||.|..|.| 
sltygdf..tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaad

LL----HQGRCLTAAESMEYYGKIRTTDGKGVTIPSQRRYVQYYG
|.    ....        |.. |.|.     |. ..| |.. .. 
lmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
0050432 (Phosphotyrosine protein) phosphatases II 19-120 4.5e-16 54.5 In-house 169-273 (308) alignment 
Range on Protein: 19-120
Range on HMM: 169-273/308.0
VVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPF--DDHNPPRIELIRPFCEDVMQWLaedKDNVAAIHCKAGKGRTGVMICALLL----HQGRCL
.|..|. ...|.|.|..|. . . |   .  .. ||.   |.. || .| .  |.| | ..|   .... ..||.|| ||||..|...||    ......
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggv

TAAESMEY
.. | . .
dvfeavkk
0051429 (Phosphotyrosine protein) phosphatases II 5-127 2.7e-13 45.7 In-house 35-203 (272) alignment 
Range on Protein: 5-127
Range on HMM: 35-203/272.0
AESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCsernydtsrFDHRVAHYPFDDHNPPRIELIR------------------------------------
|....|.....  ..| . . . ....|.. .           . |. |.|. |. .|.|....                                    
aadfwrlkelgiktivdLrseeErgrlkcdryw.........pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhl

------------PFCEDVMQWLAEdkDNVAAIHCKAGKGRTGVMICALLLHQGRC---------LTAAESMEYYGKIRTT
              . .....|..  ..   .||.|||.|||.....||| .| .         ||     |.. ..|  
hytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraq
subfamily_PRL_pd Subfamily PRL 17-113 3.2e-12 40.8 In-house 21-120 (151) alignment 
Range on Protein: 17-113
Range on HMM: 21-120/151.0
EHVVKFLNSHHQDHYKVYNLCSERNYDTSRFD---HRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGRCLT
. . || .. .. . |    . | .|||. ..    .|  ..||| ..|  |... . | ...  .|. ... |.|| || ||. |...  |. .|    
atlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmkye
subfamily_CDC14_pd Subfamily CDC14 13-141 1.8e-10 35.2 In-house 210-316 (328) alignment 
Range on Protein: 13-141
Range on HMM: 210-316/328.0
RNDMEHVVKfLNSHhqdhykvynlcserNYDTSRFD-HRVAHY--PFDDHNPPRIELIRPFCEdvmqwLAEDKDNVAAIHCKAGKGRTGVMICALLLHQG
.|....||. ||..              .|| ..|  . ..|.   | |   |  .... | |     .||. .  .|.||||| |||| .| . |... 
knnvttvvr.Lnkk..............lYdakkftdaGfdhkDlffiDGstPsdaivkkfle.....iaekaeGaiavhCkaGLGrtGtLiacylmkhy

RcLTAAESMEYYGKIRTtdgkGVTIPSQRRYV
| .||||.. .   .|     |. |  |....
r.ftaaeaiawlricrP....Gsvigpqqkfl
0048567 (Phosphotyrosine protein) phosphatases II 37-145 1.4e-09 32.5 In-house 23-135 (157) alignment 
Range on Protein: 37-145
Range on HMM: 23-135/157.0
CSERNYDTSRF--DHRVAHYPFD-DHNPPRIELIRPFCEDVMQWLA--EDKDNVAAIHCKAGK---GRTGVMICA-LLLHQGRcltaaESMEYYGKIRTT
  ...|..  |  |. . ...|  |. |. . ..  |.  ....|   | .... |.|||||    |||...|.. |.||.|         | .. .|  
lpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf.....tpeeaiaplriv

DGKGVTIPSQRRYVQYYG
. . |  . .  .. .|.
rpgsvpfrdasyllslyn
PTPc_DSPc_SM00012 51-112 2e-09 33.0 In-house 5-68 (105) alignment 
Range on Protein: 51-112
Range on HMM: 5-68/105.0
VAHYPFDDHNPPR-IELIRPFCEDVMQWLAEDK-DNVAAIHCKAGKGRTGVMICALLLHQGRCL
. ..   ||. |.  . |  ....|...  . .  .   .||.|| ||||..... .|.|  . 
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek
subfamily_PTPDC1_pd Subfamily PTPDC1 52-132 3.6e-09 31.3 In-house 86-159 (182) alignment 
Range on Protein: 52-132
Range on HMM: 86-159/182.0
AHYPFDDHNPPRIELIRPFCEdVMQWLAEDKdnVAAIHCKAGKGRTGVMICALLLHQGRcLTAAESMEyygKIRTTDGKGV
  ....|.. . .| |      |..   ...    |.|| ||.|||||.|.. |... | |||.....   ..|    | .
ynfgwkDygvasleriLdivk.vvafalqeg..kvavhChaGlGrtGvliacylvyakr.ltaekaik...lvrskrpksi
subfamily_DSP11_pd Subfamily DSP11 38-125 5.2e-09 30.3 In-house 66-157 (178) alignment 
Range on Protein: 38-125
Range on HMM: 66-157/178.0
SERNYDTSRFDHR-VAHYP--FDDHNPPRIELIRPFCEDVMQWL--AEDKDNVAAIHCKAGKGRTGVMICALLLHQgRCLTAAESMEYYGKIR
 .| |... . .. | ..      |. |. ||.. |.| | ..|   .|.|.. ..||  |  ||| .||  |...   . . ...| . ..|
tdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidv.egyepedaieafeear
subfamily_DSP23_pd Subfamily DSP23 56-123 7.4e-09 30.4 In-house 59-123 (148) alignment 
Range on Protein: 56-123
Range on HMM: 59-123/148.0
FDDHNPPRIELIRPFCEdVMQWlAEDKDNVAAIHCKAGKGRTGVMICALLLHQgRCLTAAESMEYYGK
 ||. || .| .  | . |..  ||.|..  ..||  |.|||| |.   |... | |.|||..    .
iddyhppaleqvvefvr.vvee.aeekneavsvhcllgrgrtgtmlacylvke.rklaaaeaiaevrr
subfamily_RNGTT_pd Subfamily RNGTT 15-125 3.5e-08 27.3 In-house 40-154 (189) alignment 
Range on Protein: 15-125
Range on HMM: 40-154/189.0
DMEHVVKFLNSHHQDHYKVYNLCS-ERNYDTSRFDH---RVAHYPFDDHN-PPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQg
... ....|.....    | .|   .| ||.. ...   .  .     .   |  | .. | . | .. ..  ..| ..||. |  ||| .|.. |... 
epsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvek.

RCLTAAESMEYYGKIR
..  . .... . | |
edwsveaavalFakaR
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 13-104 1.1e-07 26.2 In-house 129-222 (274) alignment 
Range on Protein: 13-104
Range on HMM: 129-222/274.0
RNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVA--AIHCKAGKGRTGVMICAL
 .  .  .|. .  ....|.| .|  .   .. .  |       | . | ... .  ....| .   |.. ..|   .|| || ||||. | ..
erygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais
Y_phosphatase3 Tyrosine phosphatase family 68-106 6.8e-07 24.4 Pfam-A 110-147 (164) alignment 
Range on Protein: 68-106
Range on HMM: 110-147/164.0
RPFCEDVMQWLAEDKdNVAAIHCKAGKGRTGVMICALLL
.. ...|.. |||.. . . .||.||| ||||..  || 
kkayrkvlealaeee.gpvlfHCtaGKDRTGvvaallls
Y_phosphatase Protein-tyrosine phosphatase 4-108 1.2e-06 23.5 Pfam-A 89-195 (235) alignment 
Range on Protein: 4-108
Range on HMM: 89-195/235.0
PAESLERMYRNDMEHVVKfLNSH-HQDHYKVYNLCSERNYDTS--RFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLaEDKDNVAAIHCKAGKGRTGV
| |. | .. .|..  .|  ... ....| ...|  . . . |  |  . . .    ||. |   . .  ....| ..  |.|..   .||.|| ||||.
peeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgt

MICALLLHQ
.... .| .
fvaldille
Y_phosphatase Protein-tyrosine phosphatase 4-108 1.2e-06 23.5 In-house 89-195 (235) alignment 
Range on Protein: 4-108
Range on HMM: 89-195/235.0
PAESLERMYRNDMEHVVKfLNSH-HQDHYKVYNLCSERNYDTS--RFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLaEDKDNVAAIHCKAGKGRTGV
| |. | .. .|..  .|  ... ....| ...|  . . . |  |  . . .    ||. |   . .  ....| ..  |.|..   .||.|| ||||.
peeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgt

MICALLLHQ
.... .| .
fvaldille
DSPc Dual specificity phosphatase, catalytic domain 53-124 3.6e-06 21.9 Pfam-A 44-113 (133) alignment 
Range on Protein: 53-124
Range on HMM: 44-113/133.0
HYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVaAIHCKAGKGRTGVMICALLLHQGRClTAAESMEYYGKI
..| .|..   |.   . . .... ..... .| ..||.||  |.. .|.| |. . .. .. | .|.  . 
ripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvker
DSPc Dual specificity phosphatase, catalytic domain 53-124 3.6e-06 21.9 In-house 44-113 (133) alignment 
Range on Protein: 53-124
Range on HMM: 44-113/133.0
HYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVaAIHCKAGKGRTGVMICALLLHQGRClTAAESMEYYGKI
..| .|..   |.   . . .... ..... .| ..||.||  |.. .|.| |. . .. .. | .|.  . 
ripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvker
DSPc_SM00195 12-106 4.9e-06 21.4 In-house 122-218 (263) alignment 
Range on Protein: 12-106
Range on HMM: 122-218/263.0
YRNDMEHVVKFLNSHHQD-HYKVYNLCSERNYD-TSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLAEDkDNVAAIHCKAGKGRTGVMICALLL
. .  .  ||. . .... ......|  . . . ..|. . . .    ||. |   . .. . . | ..  .  ..   .||.|| ||||..... ..
ketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 12-106 4.9e-06 21.4 In-house 122-218 (263) alignment 
Range on Protein: 12-106
Range on HMM: 122-218/263.0
YRNDMEHVVKFLNSHHQD-HYKVYNLCSERNYD-TSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLAEDkDNVAAIHCKAGKGRTGVMICALLL
. .  .  ||. . .... ......|  . . . ..|. . . .    ||. |   . .. . . | ..  .  ..   .||.|| ||||..... ..
ketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidii
subfamily_PTPRB_pd Subfamily PTPRB 20-106 6.8e-06 20.3 In-house 154-241 (293) alignment 
Range on Protein: 20-106
Range on HMM: 154-241/293.0
VKFLNSHHQDHYKVYNLCSERNYDTsRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWL-AEDKDNVAAIHCKAGKGRTGVMICALLL
|........... . .|  |.. .. |  ..  .  . ||. | . . .  |.. | ...  . ...   .|| || ||||. |.   |
vtlvaeeeledwvirelkiekekee.rkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl