Gene Tensin in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP046_AA protein Get Run
SpurP046_AA_191-377 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 192-377 1.1e-94 308.3 In-house 4-189 (189) alignment 
Range on Protein: 192-377
Range on HMM: 4-189/189.0
LVRYSFDLEVDYITERLIAVSFPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNLSRRRHDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNL
.|....||...|||||.||.|||. |||..||.||.||...||||||..|.|||||..|.|.||||..|.|.|||..|||.||.||||||....|.| ..
yveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadp

NNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLDAKGWSGMHPSQMRYIDYFSGLLTNSIQINSSPLFLHHAVI
.||||.|||||.| |||||||.|.| .|....|...||.|||||||.| .. ..|||.||..||||||...|..||||||||....
qnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil
subfamily_Auxilin_pd Subfamily Auxilin 198-360 3e-43 140.4 In-house 8-165 (166) alignment 
Range on Protein: 198-360
Range on HMM: 8-165/166.0
DLEVDYITERLIAVSFPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNLSRRRHDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNLNNVVVL
||.. ||| |.| .|||. |.|  |. |. ||  .| |.| . |.|.||| | .. .||.. | . |||.  ||.|| | ..|... .|.| . .||||.
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLDAkgwsgMHPSQMRYIDYFSGLLT
||| || . .|.|||.. .. . |  .|...  ..||         ..||. ||. |...||.
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla
subfamily_PTEN_pd Subfamily PTEN 195-362 1.5e-42 140.6 In-house 16-182 (184) alignment 
Range on Protein: 195-362
Range on HMM: 16-182/184.0
YSFDLEVDYITERLIAVSFPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNL-SRRRHDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNLNN
  .||.. ||||..||...|. .||. || .|.|||..|..||...| ..|| | |..| .|....|  ..  .  .|||| | .|....|.|.. . .|
dgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkkn

VVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLDAKGWSgmHPSQMRYIDYFSGLLTNS
|||.||| |.|  ||...|.. .  ... ...... .| .|. ..||     |||.||..|.. ||...
vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvt..iPsqrRYveYyeklleee
subfamily_VSP_pd Subfamily VSP 194-359 4.8e-35 115.4 In-house 29-198 (212) alignment 
Range on Protein: 194-359
Range on HMM: 29-198/212.0
RYSFDLEVDYITERLIAVSFPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNL-SRRRHDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNLN
.  |||.. |.|||.||.|||| | .. ||  ...|.|.|. ||.. | |.|| | | .| . .|..|. .   .   | ||.| ...|... |.. .|.
qdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlk

NVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLD--AKGWSGM-HPSQMRYIDYFSGLL
||...|||||.|  | .| |.. .  | .  . ..|  . .|     .. . |.  ||| ||..|.  . 
nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 365-490 3.1e-28 89.6 Pfam-A 1-133 (134) alignment 
Range on Protein: 365-490
Range on HMM: 1-133/134.0
INSSPLFLHHAVIHGVPNYDSNGGCRPFLRIYQGMSPV-YTSGVYTVPEGT--SRFVITPRSAIPLRGDILLKCYHKKFRSTTRDTVFRCQFHTTAVM--
.|...|.|.. ...|.||....|||.|....|.|. .| .... |. .. .    |...    .|..||.|....||. .. ... .||..|.|. .   
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiekn

EYRLVFQKQELDDACTD--ARFPEFTKVELIFS
...| ..|.|||.|. |   .|..  ||||.|.
qnvltlpkneLDkalkdkdkkfsknfkvelvfe
PTEN_1 194-361 4e-28 93.6 In-house 15-194 (196) alignment 
Range on Protein: 194-361
Range on HMM: 15-194/196.0
RYSFDLEVDYITERLIAVS-FPSGG-----LENQYRSNLRDVVRMLKSKHNNS-YVVFNLSRRRHD---------VSKLNQEVRDLGWPNVLAPPLERLC
. ...|.. |||.|.||.. .|| .      |. || .|.||...|.... .. . |.||| ....           | . |.......   ||.|..|.
lptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslself

SICKQMETWMKGNL-NNVVVLHCKGGRGPIGVVVSAFMNYLSItSANDSTMDRHAMKRFLDAKGwsgmHPSQMRYIDYFSGLLTN
 |||... |.. .  .|||. |||.|.|  |.|| |.. |.   .  | .... . ||   |.      ||| |.. ||. || .
dicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
0036282 (Phosphotyrosine protein) phosphatases II 199-362 2.8e-25 84.4 In-house 10-172 (174) alignment 
Range on Protein: 199-362
Range on HMM: 10-172/174.0
LEVDYITERLIAVSFPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNLS-RRRHDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNLNNVVVL
| . |||.|||| ..|   .|  .. ....||..|..|....| ..|.  ..|.| ..|. .. .|.||   .|.|. |....|..|.... . ...|. 
ldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlV

HCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLdaKGWSGMHPSQMRYIDYFSGLLTNS
||..|.|  |..| |.. .  . .  .  .|  ...|.   ....  .|||.|.. ||. ||..|
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgs
0046846 (Phosphotyrosine protein) phosphatases II 195-359 8.2e-19 63.5 In-house 6-172 (176) alignment 
Range on Protein: 195-359
Range on HMM: 6-172/176.0
YSFDLEVDYITERLIAVSFPSGGLeNQYRSNLRDVVRMLKSKhnNSYVVFNLSRRR-----------HDVSKLNQEVRDLGWPNVLAPPLERLCSICKQM
. .|| .|||...||. |.|  .    ....| | ..|||.   . ..|.||  ..           ... ||. ..  |.||   .|.|| |.......
lgldldldyinanlilgsrpiatq.gplprtladflemlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefi

ETWMKGNlnNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLdakgWSGMHPSQMRYIDYFSGLL
... | .  ..|. ||..|.|  |..| |.. .|.     . ....  ..|.|    ..  .|.|.|.. .|  ||
realkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyefelll
0038934 (Phosphotyrosine protein) phosphatases II 202-340 1.1e-18 63.0 In-house 14-157 (194) alignment 
Range on Protein: 202-340
Range on HMM: 14-157/194.0
DYITERLIAVSFPSGG-----LENQYRSNLRDVVRMLKSKHNNSYVVFNLS--RRRHDVSKLN---QEVRDLGWPN-VLAPPLERLCSICKQMETWMKGN
|.||.|.|| ..|. |     .|. || ...|.||.||... . . | .|.   |  |....     |. .| .|.   .|.|| |..... ...... .
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned

LNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDStMDRHAMKRfldakG
 ..||. |||.|.|  |..| |.. |    ||... ... ..||     .
pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA.ialfrekR.....p
0039614 (Phosphotyrosine protein) phosphatases II 196-355 1.1e-15 53.4 In-house 80-284 (297) alignment 
Range on Protein: 196-355
Range on HMM: 80-284/297.0
SFDLEVDYI-----------TERLIAVSFPSGGLEN-----QYRSNLRDVV----------------------------RMLKSKHNNSYVVFNLSRRRH
..||. |||           | . || ..|. .  .      .. . . .|                            ..|| .|.. |.|..|. ...
gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnn

DVSKLNQEVRDLGWPNVLAPP-LERLCSICKQMETWMKGN-LNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTmDRHAMKRFLDAKGWSGMHPSQM
. |.  . .  .|||   .|| || |............ .  ...|. ||..| |  |... |.. .  . .  . .   .|.|..  ..... . |||.
gesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqy

RYIDYF
|.. ..
rflyda
0043336 (Phosphotyrosine protein) phosphatases II 194-354 4.9e-15 51.2 In-house 66-271 (278) alignment 
Range on Protein: 194-354
Range on HMM: 66-271/278.0
RYSFDLEVDYI----------TERLIAVSFPSGGLENQYRSNLRD----------------------------------VVRMLKSKHNNSYVVFNLSRR
 ...||  |||          ... || ..|. . .. ..  ...                                  .|..|| .|.. |.|..|   
llggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevt

--RHDVSKLNQEVRDLGWPNVLAP-PLERLCSICKQMETWMKgNLNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTmDRHAMKRFLDAKGWSGMHP
  ... |.  . .  ||||   .| .|. |....|.. .... . |..|. ||..| |  |... ... .  . .    .   .|.|..   .... . |
nlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtp

SQMRYIDY
||.|.. .
sqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 197-355 6.8e-15 50.7 In-house 35-237 (243) alignment 
Range on Protein: 197-355
Range on HMM: 35-237/243.0
FDLEVDYITERLIAVSFPSGGLENQ---------YRSNLRDVV----------------------------RMLKSKHNNSYVVFNLSRRR---HDVSKL
...   |.|.|||| ..|  .  ..         .. . . .|                            ..|...| ..|.|..|. ..    |...|
inanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrl

NQEVRDLGWPNVLAPP-LERLCSICKQMETWMKG-------NLNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTMDRHAMKRFLdakgWSGMHPSQ
.. .  |.||   .|.  | | ...... ....        . ...|..||..|.|  |... |.. .| ..   ......  ..|.     ..   |||
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....kavqtpsq

MRYIDYF
.|.. ..
yrflyea
0041856 (Phosphotyrosine protein) phosphatases II 192-356 9.4e-15 50.1 In-house 10-167 (182) alignment 
Range on Protein: 192-356
Range on HMM: 10-167/182.0
LVRYSFDLEVDYITERLIAVSFPSGGLENQYRSNLRDVVRMLKSKHNNSY-VVFNLSRRRHDVSKLNQ---EVRDLGWPNVLAPPLERLCSICKQMETwm
 ..| ...  |||...|.. |.|.   .  ..  |..| ..|.  ... . .. ||. .... ..|..   ....|.||   .|.|. |........   
ilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle..

kgnLNNVVVLHCKGGRGPIGVVVSAFMNYLSitsandSTMDRHAMKRFLDAKGWSGMHPSQMRYIDYFS
    ...|. ||..|.|  |..| |.. .        .   ..|.| .  ..  .  .|.|.... .. 
...eggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklvrsrRpgmvitpnqyfflqlal
0043147 (Phosphotyrosine protein) phosphatases II 198-359 8.2e-14 47.2 In-house 12-160 (172) alignment 
Range on Protein: 198-359
Range on HMM: 12-160/172.0
DLEVDYITERLIAVSFPsgglenqYRSNLRDVVRMLKSKHNNSyvVFNLSRR---RHDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNLNNV
.|.. ||. |.||  .|       .|..| |..||||... .   ..|| ..   . ....|. ..  |.||   .|.|| | ..........  . ...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

VVLHCKGGRGPIGVVVSAFMNYlsitsandST-MDRHAMKRFLDAKGWSGMHPSQMRYIDYFSGLL
|. ||..| |  |..| |.. .              .|.. . ......  .|||.|.. ||. ||
vlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsqyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 194-354 8.7e-14 47.0 In-house 30-237 (245) alignment 
Range on Protein: 194-354
Range on HMM: 30-237/245.0
RYSFDLEVDYI----------TERLIAVSFPSGGLEN-----QYRSNLRDVV------------------------------RMLKSKHNNSYVVFNLSR
 ...|| .|||          |...|| ..|. .  .      .. ... .|                              ..|. .|...|.|..|. 
pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlev

R--RHDVSKLNQEVRDLGWPNVLAPP-LERLCSICKQMETWMKGNLNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTmDRHAMKRFLDAKGWSGMH
   ..| |. .. .. |.||   .|. || |..... ...... . |..|. ||..|.|  |... |.. .  . .  . .   .|.|.. . .... . 
tnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs.leeavkelrsqRpgavqt

PSQMRYIDY
|||.|.. .
psqyrflye
0048076 (Phosphotyrosine protein) phosphatases II 213-356 1.6e-13 46.1 In-house 3-139 (145) alignment 
Range on Protein: 213-356
Range on HMM: 3-139/145.0
FPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNLSRRRHDVSKLNQEVRDLGWPNVLAPPL-ERLCSICKQMETWMKGNlnNVVVLHCKGGRGPIGVVVS
.||  |.. |...| .....   |... . |.||.. ......|. ..  |.||   .|.| | |.......|...| .  ..|. ||. |.|  |..| 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

AFMNYLsitsaNDsTMDRHAMKRFLDAKGWSGMHPSQMRYIDYFS
|.. .|     ..     .|....  .  .. ..|.|.|.. .| 
aylmll.....lg.vsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 213-356 2.3e-12 42.3 In-house 3-141 (144) alignment 
Range on Protein: 213-356
Range on HMM: 3-141/144.0
FPSGGLENQYRSNLRDVVRMLKSKHNNSYVVFNLSRRRHDVSKLNQ--EVRDLGWPNVLAPPL-ERLCSICKQMETWMKGNlnNVVVLHCKGGRGPIGVV
.||  |.. |...| .....   |... . |.||.  ..  .  ..  ..  |.||.  .|.| | |..... .|.... .  ..|. ||..|.|  |..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VSAFMNYlsitsANDSTmDRHAMKRFLDAKGWSGMHPSQMRYIDYFS
| |.. .      .. .   .|....  .  .. ..|.|.|.. ...
vaaylmk.....klgls.leealalvrsrrpgavpnpgqlrfLleye
SH2 SH2 domain 2820-2913 5.6e-12 36.2 Pfam-A 1-77 (77) alignment 
Range on Protein: 2820-2913
Range on HMM: 1-77/77.0
WYKPSITRDDAINILKD-RPPGTFIVRDSNSFPGAFGLALKVAQvpanttprkggdpqseLVRHFLIEPNARGvrlKG-CVNEPVFSSLSALIYQH
||  .|.|..| ..|.. ...|||.||.|.|.|| . |...  .                 |.|. |. ...|   |  . ..  ||||. |.. .
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg................kvkhyriqsleng...kyyitenekfsslqeLvehY
0049260 (Phosphotyrosine protein) phosphatases II 218-359 1.9e-10 36.1 In-house 14-149 (152) alignment 
Range on Protein: 218-359
Range on HMM: 14-149/152.0
LENQYRSNLRDVVRMLKSKHNNSYVVFNLSRRR-HDVSKLNQEVRDLGWPNVLAPPLERLCSICKQMETWMKGNLNNVVVLHCKGGRGPIGVVVSAFMNY
 .  .. .| |..||||. . . .|. .    . ..  .   ..  | ||   .|.|. |  .. ..  ... . ...|. ||..| |  |..| |.. .
tqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

lsitsandSTM-DRHAMKRFLDAKGWSGMHPSQMRYIDYFSGLL
          .   .|....  ..  .  .|.|.|.. .|..||
........lgvsleeavalvrekRpgavpnpgqlrflyefekll
0051082 (Phosphotyrosine protein) phosphatases II 201-328 4e-10 35.0 In-house 8-120 (151) alignment 
Range on Protein: 201-328
Range on HMM: 8-120/151.0
VDYITERLIAVSFPSGglenqyrsnlrDVVRMLksKHNNSYVVFNLSRRR---HDVSKLNQ---EVRDLGWPNVLAPPLERLCSICKQMETWMKGNLNNV
  |.|..|.. ..|.            |....|  |... ....||       .. . |..   ||... ...  .|.|. .  .....  ..  . |..
fsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngp

VVLHCKGGRGPIGVVVSAFMNYLSitsandstMD
|. ||..|.|  |..| ... .|         ..
vlvHCsaGkgRTGtlvalylmllg........vs
0046845 (Phosphotyrosine protein) phosphatases II 197-352 6.2e-10 34.4 In-house 68-266 (284) alignment 
Range on Protein: 197-352
Range on HMM: 68-266/284.0
FDLEVDYITERLIAVSFPSGG-----------------------------LENQYRSNLRDVVRM-------LKSKHNNSYVVFNLSRRRHDVSKLNQEV
.||.. ||. . || ..|  .                                ||...  .|...       |. .....|.|..|. .......   .|
ydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtv

RD---LGWPNVLAPP-LERLCSICKQMETWMKG-NLNNVVVLHCKGGRGPIGVVVSAFMNYLSITSAND--STMDRHAMKRFLDAKGWSGMHPSQMRYI
.    ..||.  .|| .| | ...........  . ....| ||..| |  |... . . .  .   ..       .|.||. . .  .   ..|.|..
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
0045450 (Phosphotyrosine protein) phosphatases II 201-352 8.9e-10 34.2 In-house 107-296 (307) alignment 
Range on Protein: 201-352
Range on HMM: 107-296/307.0
VDYI----------------------------------TERLIAVSFPSGGLENQYRSnlrDVVRMLKSKHNNSYVVFNLSRRRHDVSKLNQEVRDLGW-
  .|                                  . . .|  .|. | | .|.    ..|..|. .| ..|.|..|   ..| ..   .|. . . 
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

--PNVLAPP-LERLCSICKQMETWMKGN-LNNVVVLHCKGGRGPIGVVVSAFMNYLSITSAND---STmDRHAMKRFLDAKGWSGMHPSQMRYI
  |.  .|| .| |............ .  ...|. ||..| |  |... |.. .  . . .     .  ..|.|.. . ....   |.|.|..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.lleavkllreqRpgavqnpeqyrfl
0040438 (Phosphotyrosine protein) phosphatases II 192-354 1.5e-09 33.0 In-house 62-270 (317) alignment 
Range on Protein: 192-354
Range on HMM: 62-270/317.0
LVRYSFDLEVDYI----------TERLIAVSFPSGG-----LENQYRSNLRDVVRMLKSK------------------------------HNNSYVVFNL
|  ...||. |||          . . || ..|  .     ..  .. ... .|.. ...                              .........|
LsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtl

SRR--RHDVSKLNQEVRDLGWPNVLAPP-LERLCSICKQMETWMKgNLNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTmDRHAMKRFLDAKGWSG
     ... |  ..    .|||   .|| .. | ........... . ...|. ||..| |  |... |.. .  .   .. .   .|.|..  ... . 
evedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.veeavkelreqRpgav

MHPSQMRYIDY
  |.|.|.. .
qtpeqyrflyd
0040439 (Phosphotyrosine protein) phosphatases II 199-355 2.6e-09 32.6 In-house 47-241 (249) alignment 
Range on Protein: 199-355
Range on HMM: 47-241/249.0
LEVDYITERLIAVSFPSGGLENQYRSNLRD-----------------------------------VVRMLKSKHNNSYVVFNLSRR--RHDVSKLNQEVR
... ||. |.|| ..|  .  . ..  |..                                   .|..|. .....|.|..|      .. |   . ..
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

DLGWPNVLAP-PLERLCSICKQMETWMKGN-LNNVVVLHCKGGRGPIGVVVSAFMNYLSITSANDSTmDRHAMKRFLDAKGWSGMHPSQMRYIDYF
 ..||   .|  .| |............ .  ...|. ||..| |  |... |.. .  .   .. .   .|.| . ...... . |.|.|.. ..
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyea
0044763 (Phosphotyrosine protein) phosphatases II 195-356 1.3e-08 30.2 In-house 17-167 (178) alignment 
Range on Protein: 195-356
Range on HMM: 17-167/178.0
YSFDLEVDYITERLIAVSFPSgglenqyrsnlRDVVRMLKSkhNNSYVVFNLSR---------RRHDVSKLNQEVRDLGWPNVLAPP-LERLCSICKQME
.|. . ...|...|.. |.|.            | ...||   ..  .. ||.           . .... . ... ...|   .|. || .  ... .|
rsdyinaseilpglylgslpp...........addlellke..lgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefie

TWMKgNLNNVVVLHCKGGRGPIGVVVSAF-MNYLsitsandsTMDRHAMKRFL-DAKGwSGMHPSQMRYIDYFS
.... . ...|. ||. |.|  |..| |. | .|         .. ..  ...  ..     .|.|.|.. .| 
eald.ekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvrerRp.ivpnpgqlrqLyefe
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 19-65 3.1e-08 23.2 Pfam-A 1-50 (53) alignment 
Range on Protein: 19-65
Range on HMM: 1-50/53.0
HTFKTRVFRNPHSCGFCKEII---WNEGRICRVCRFACHKKCEYKVMTTC
| .. | |..|..|  |....   .  |  |. | . .||||  || . |
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkec
0045098 (Phosphotyrosine protein) phosphatases II 198-355 5e-08 28.2 In-house 6-267 (278) alignment 
Range on Protein: 198-355
Range on HMM: 6-267/278.0
DLEVDYITERLIAVSFPSGGLENQYRSNLR-------------------------------------------DVVRML------------KSKHN----
.| . ...|.|.. ..||  ....|..||                                            |  |||            . ...    
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

-------------------------------NSYVVFNLSRRRHDVSKLNQEVRDL-GWPNVLAPPLE---RLCSICKQMETWMK------------GNL
                                 . | ||. .|.|  ... .. .. .||   .|.|.    . ....... ..|             . 
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

NNVVVLHCKGGRGPIGVVVSAFMNYLSItsanDSTMDRHAMKRFLDAKGW--SGMHPSQMRYIDYF
...|. ||. | |  |..| |.. .  .    ....|     ..|  . .  . ....|.|.. .|
ggpvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyef
0047943 (Phosphotyrosine protein) phosphatases II 229-352 1e-07 27.2 In-house 138-264 (273) alignment 
Range on Protein: 229-352
Range on HMM: 138-264/273.0
VVRMLKSKHNNSYVVFNLSRRR--HDVSKLNQEVRDLGWPNVLAP-PLERLCSICKQMETWMKGN-LNNVVVLHCKGGRGPIGVVVSAFMNYLSITSAND
 |..|. .....|.|..|  ..   . |.  . .  .|||.  .|  || | ........... .  |..|| ||..| |  |... ... .  .   . 
tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekegg

STmDRHAMKRFLDAKGWSGMHPSQMRYI
 .    |.|.. . .  . . |.|.|..
vd.vleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 229-322 2.1e-07 26.2 In-house 150-249 (288) alignment 
Range on Protein: 229-322
Range on HMM: 150-249/288.0
VVRMLKSKHNNSYVVFNLSRR------RHDVSKLNQEVRDLGWPNVLAPP-LERLCSICKQMETWMKgNLNNVVVLHCKGGRGPIGVVVSAFMNYLSITS
.|..|. .....|.|..|  .       .. |.  .    ..||.  .|. .| | ...... .... . ...|| ||. | |  |... ... .  .  
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

A
 
e
PTPc_DSPc_SM00012 261-377 2e-06 23.3 In-house 6-104 (105) alignment 
Range on Protein: 261-377
Range on HMM: 6-104/105.0
RDLGWPNVLAPP-LERLCSICKQMETWMKGNL-NNVVVLHCKGGRGPIGVVVSAFMNYLSITSANdstmdrhamkrfldakgwsgMHPSQMRYIDYFSGL
  .|||.  .|   . ............. .  .. ||.||. | |  |..| . . . .... .                      ... ... ..   
hytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkelrkq

LTNSIQINSSPLFLHHAVI
  ...| .   |||..|..
Rpgmvqteeqylflyrall