Gene SpurPTP-Un-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP048_AA protein Get Run
SpurP048_AA_648-935 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CG42327_pd Subfamily CG42327 658-862 3.5e-103 339.6 In-house 1-193 (319) alignment 
Range on Protein: 658-862
Range on HMM: 1-193/319.0
YSYREAIAEEFENLPghQLIASSDikkriAVPVTSKPRSPVIQSpertrVPIPPTSPTSPSIPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAF
...||..||||..||  ||||..|     .||||||..|.||..     ||.|.|......|.....|..||||..||||....|||.|.||..|||..|
verredvaeefrdlP..qliarad.....evPvtskdksrvinv.....vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdf

WRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFsNWLDSEIPSSPQALMSML
||||||||||.||.|....||| |||..|.||||....|.|||.|||||||......|..||||...|.|...|..||||. .||..|.|....||..||
wrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml

LQVHNT
|.|...
levrss
0050432 (Phosphotyrosine protein) phosphatases II 661-935 6.4e-61 201.7 In-house 41-300 (308) alignment 
Range on Protein: 661-935
Range on HMM: 41-300/308.0
REAIAEEFENLPGHQLiaSSDIKKRIAVPVTSKPRSPVIQSPERTRVPIpptsptspsipsKPSDFFLDASFIRGYD-SSHCSYIGATVSGGDSSTAFWR
.  . |||| |.  .   . ...    .   .| |.. |   ...|| .            .... . .||...||.  . . .| .     ..   |||
lglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl............degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

TVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQ
 ||||..|.||.|....| | . |.||||...|| |.. ||.. |||.   . ..| . || ..|....  | |||... || |  .|.||..|...| .
mvweqnvrvIvmLtklvengrekcaqYwplelgg.gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VHNTHQEsyGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
|......  ||.|||||.|||||| .|| |. ...||. ..||....|  .|. | ... . .|| |.||.|.|. |
vrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0051299 (Phosphotyrosine protein) phosphatases II 649-933 1.1e-60 200.9 In-house 10-285 (288) alignment 
Range on Protein: 649-933
Range on HMM: 10-285/288.0
LTSNALAKFYSYREAIAEEFENLPGHQLIasSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspSIPSKPSDFFLDASFIRGYDSSHCsYIGATV
|..  |..  .    ..|||| |.  .     ...  . .   .| |.. |   ...|| .        .... ... . .||.|.||....  .| .  
llklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLs.......vldgvegsdYinAsyidgynlkrk.fIatqg

SGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV----EKSLCRPVTHYWFSNWLDS
   ..   ||| ||||..|.||.|....||| . |.||||.     |.. ||.| |||.   . ..| . || ..|.     .. .| |||... || | 
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

EIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|.||..|...| .|.. .. . ||||||||.|||||| .|| |. ...||. ..||....|  .|. | ... . .|| |.|..|.|.
gvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0046845 (Phosphotyrosine protein) phosphatases II 664-935 6.2e-60 198.3 In-house 2-275 (284) alignment 
Range on Protein: 664-935
Range on HMM: 2-275/284.0
IAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDFFLDASFIRGYD----SSHCSYIGATVSGGDSSTAFWR
. |||| |.  .   . ...  ...   || |.. |   ...|| . .....       ... . .||...|||     ... .| .     ..   |||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd......ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwr

TVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVE-KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLL
 ||||..|.||.|... | |.  |.||||..    ... ||.. |||.     ..| . || ..|.. ..  | |||... .| |  .|.||. |...| 
mvweqnvrvIVmltelvengrekcaqYwple...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

QVHNTHQ--ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESH---TVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
.|.. ..  .. ||.|||||.|||||| .|| |. ...||. .   .||....|. .|. | ... . .|| |.|..|.|. |
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0047943 (Phosphotyrosine protein) phosphatases II 662-933 7.7e-59 194.7 In-house 12-271 (273) alignment 
Range on Protein: 662-933
Range on HMM: 12-271/273.0
EAIAEEFENLPGHQLiaSSDIKKRIAVPVTSKPRSPVIQSPERTRVPIpptsptspsipSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRTV
  ..|||| |.  .   . ...  . .   .| |.. |   ...|| .           . ... .  ||...||....  .| .     ..   ||| |
tllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl...........gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmv

WEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVH
|||..|.||.|....|||.. |.||||...|.  .. ||.. |||..  . ..| . || ..|.. . .| |||... .| |  .|.|.. |.... .|.
weqnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

NTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
.....  | ||||||||.|||||| .|| |. ...||. ..||.. .|  .|. |  .. . .|| |.|..|.|.
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 661-935 1.6e-58 193.7 In-house 12-278 (297) alignment 
Range on Protein: 661-935
Range on HMM: 12-278/297.0
REAIAEEFENLPGHQLIASSDIKKRIavPVTSKPRSPVIQSPERTRVPIpptsptspsipSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRT
.  . .||| |. ..|. | .. ..      .| |.. |   ..||| .           ..... . .||.. ||| ..  .| .     ..   ||| 
lalllkefeellpllllgslsvallp..enleknRykdilpydhtRVkl...........ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrm

VWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTqlYGNILVTLKGGAS--GEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLL
||||....||.|....|||.. |.||||..||.. |  ||.. |||..  .   ..| . || . .....  | |||... .| |  .|.||. |.... 
vweqnvtvIvmltelvelgrekcaqywpleegeslt..ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

QVHNTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLE---ESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
.|.. ...  | |||.||||.||||.| .|| |. .|.||   . ..|||. .| ..|. | .|. . .|| |.|..|.|. |
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_PTPRD_pd Subfamily PTPRD 727-937 1.5e-57 190.5 In-house 78-284 (564) alignment 
Range on Protein: 727-937
Range on HMM: 78-284/564.0
FLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKegGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE
.  |||| ||. .. .|| .     ..   ||| ||||.|.||| | .  | ||  | .|||.|  |  |. ||.. |||.     ..|   |. ... .
YINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g..tetygeltVtleeeeeladyeirtfklkkkk

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAF
.|  | |... | .| |. .| |...|.... .|......  ||.||||| ||||||  |. |. ..|..|..||||  .|. .|..|   . . .||.|
ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiF

IYRTLYEFSKFL
|.....|. .. 
iheailealacg
0039614 (Phosphotyrosine protein) phosphatases II 661-935 8.6e-57 188.2 In-house 31-290 (297) alignment 
Range on Protein: 661-935
Range on HMM: 31-290/297.0
REAIAEEFENLPGHQLiassDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSptspsiPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRT
.  . .|||.|.  .     |..    .   .| |.. |   ...|| . |         . ... .  ||.. |||     .| .     ..   ||| 
ktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkped......gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VWEQQSRTIVCLCSPYELGKVCPQYWPTKEGgpgtqLYGNILVTLKGGASGEHYFTSTLLIRNveKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVH
||||....||.|... |||. |.||||...|      ||.. |||..    ..|.. || ..|  ..  | |||... .| |  .|.|.. |...| .|.
vweqgvtvivmLtklvelgrkcaqywpeegg.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

NTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
. ..|  . |||.||||.|||||| .|| .. ...||. ..||....|. .|. |..|. . .|| |.|. |.|. |
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0040438 (Phosphotyrosine protein) phosphatases II 657-936 1.8e-56 187.1 In-house 13-278 (317) alignment 
Range on Protein: 657-936
Range on HMM: 13-278/317.0
FYSYREAIAEEFENLPGHQLIassDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTA
..|   |. ||||.|.  .|    ...  . .   .| |.| |   ...|| . |       ... ... .  ||.. |.. ..  .| . .   ..   
lksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsp.......lggdldsdYInAsyvdgpnlkrk.fIatqgPlpntved

FWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSM
||| ||||....||.|... ||| . | ||||.     .|. ||.. |||..    ...   || . . ..| .| |||... .| |  .|.||. | ..
FwrmvweqgvtvivmLteleelgrekcaqYwpl....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldf

LLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKF
| .|..  ... |||.||||.|||||| .|| .. ...||. ..||....|  .|. |..|. . .|| |.|. |.|. |.
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0043336 (Phosphotyrosine protein) phosphatases II 649-933 9.1e-56 184.7 In-house 7-276 (278) alignment 
Range on Protein: 649-933
Range on HMM: 7-276/278.0
LTSNALAKFYSYREAIAEEFENLPGHQLiasSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCsYIGATV
|    | ...... .. .|||.|.  .|    ...  . .   .| |.. |   ...|| . .       ... ... .  ||.. ||. ..  .| .  
llkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsl.......lggdldsdYinAsyvdgynvprk.fiatqg

SGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPtkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPS
   ..   ||| |||....|||.|... |||.| | ||||      |.. ||.. |||..  . ..| . || . |  .. .| ||||.. .| | ..|.
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe

SPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
|.. |...| .|..  . | |||.||||.||||||..|| .. ...||  ..||....|. .|. |..|. . .|| |.|. |.|.
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 654-933 5.7e-55 182.6 In-house 19-303 (307) alignment 
Range on Protein: 654-933
Range on HMM: 19-303/307.0
LAKFYSYREAIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSptspsiPSKPSDFFLDASFI--------RGYDSsHCSYIG
| .  . .. ...||| |.  . . . ...    .   .| |.. |   ..||| . ...      .| ... . .||..         |||.    .| 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssld......gsledsdYiNAsyvrvpllllldgydl.krkfIa

ATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV-EKSLCRPVTHYWFSNWLDS
. .   ..   ||| .|||....||.|... |||.. |.||||..    ... |||. |||..    ..|   || . .  ...  | |||... .| | 
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

EIPSSPQALMSMLLQVHNTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT---VDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|.|.. | ... .|.. ..|  . |||.||||.|||||| .|| .. ...||. .|   ||....|. .|. |..|. | .|| |.|. |.|.
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 692-931 2.2e-53 176.5 Pfam-A 3-234 (235) alignment 
Range on Protein: 692-931
Range on HMM: 3-234/235.0
SKPRSPVIQSPERTRVPIpptsptspSIPSKPSDfFLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKE
.| |.. |   ..||| .        .  ..||| .  |....||. .. ..| .     ..   ||| ||......||.|.|  | | . |.||||..|
kknRykdilpydktrvkl........kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

GGpgTQLYGNILVTLK-GGA-SGEHYFTSTLLIRNVEKS-LCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIAT
..  .. ||.| |.||       ..| ...| ... ...   | |..... || |...|.||..|.... .|....... ||||||||.|||||| ..| 
ee..sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLY
|| ...||. ..||. ..|...|. | ... ...||.|.|... 
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 692-931 2.2e-53 176.5 In-house 3-234 (235) alignment 
Range on Protein: 692-931
Range on HMM: 3-234/235.0
SKPRSPVIQSPERTRVPIpptsptspSIPSKPSDfFLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKE
.| |.. |   ..||| .        .  ..||| .  |....||. .. ..| .     ..   ||| ||......||.|.|  | | . |.||||..|
kknRykdilpydktrvkl........kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

GGpgTQLYGNILVTLK-GGA-SGEHYFTSTLLIRNVEKS-LCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIAT
..  .. ||.| |.||       ..| ...| ... ...   | |..... || |...|.||..|.... .|....... ||||||||.|||||| ..| 
ee..sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLY
|| ...||. ..||. ..|...|. | ... ...||.|.|... 
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
DSPc_SM00195 681-933 4.2e-52 172.4 In-house 17-261 (263) alignment 
Range on Protein: 681-933
Range on HMM: 17-261/263.0
DIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipskPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK
.... .    .|| |.  |   ..||| ....  .       ... .. |..|.|. ..  .|| .     .    |||.|||.....||.|... | ||
etteaekkknksknRyknilpydhtrVklkkeekk.......egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

-VCPQYWPTKEggPGTQLYGNILVTLKGGASGE-HYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGV
  | .||| ..   |.. .|.| |.|.   . . .. . || ... .|.  | ||.|.. || |...|.|.. ....| .|......| ||.|||||.||
ekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
|||| ....|| ...||| ..||| ..|...|. | ... . .||.|||... |.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 681-933 4.2e-52 172.4 In-house 17-261 (263) alignment 
Range on Protein: 681-933
Range on HMM: 17-261/263.0
DIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipskPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK
.... .    .|| |.  |   ..||| ....  .       ... .. |..|.|. ..  .|| .     .    |||.|||.....||.|... | ||
etteaekkknksknRyknilpydhtrVklkkeekk.......egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

-VCPQYWPTKEggPGTQLYGNILVTLKGGASGE-HYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGV
  | .||| ..   |.. .|.| |.|.   . . .. . || ... .|.  | ||.|.. || |...|.|.. ....| .|......| ||.|||||.||
ekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
|||| ....|| ...||| ..||| ..|...|. | ... . .||.|||... |.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 687-936 4.6e-50 165.2 In-house 25-270 (274) alignment 
Range on Protein: 687-936
Range on HMM: 25-270/274.0
AVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQY
    ..| |   |   |..|| . . |..      ..   ...| .|.|||  .  |. .        . ||| ....... || |    |  .  | .|
vfgsqtknryktilPnensrvllesesse......dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKslCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQES---YGPVVVHCSDGVGRTG
.|..|.   .. ||.. .. ..  . ..|   .|.....|.  .| |.|||...| | . | ....|....|.|.....|.    .||||||| |.||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

LVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKF
  ||..| ...|.|...||. ..|. .|.|||  . . .|| .|.|.|... | 
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0042113 (Phosphotyrosine protein) phosphatases II 693-933 7.1e-50 165.1 In-house 12-242 (245) alignment 
Range on Protein: 693-933
Range on HMM: 12-242/245.0
KPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGdSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTkeg
| |.. |   ..||| ..|       ... . . .  ||.. ||. ..  ....  . . .  .||| .||....|||.|... |||.| |.||||.   
knrysdilpydhtrvklsp.......dggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywpl...

gPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ-ESYGPVVVHCSDGVGRTGLVIATDIN
  ... ||.. |||..  . ..| . || . |. ..  | |.||.. .| |  .|.... | ..|  |..  .  | |||.||||.||||||..|| .. 
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

MQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
...||. ..|.....|  .|. |..|. . .|| |.|. |.|.
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 693-933 1.7e-49 164.0 In-house 14-245 (249) alignment 
Range on Protein: 693-933
Range on HMM: 14-245/249.0
KPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTkeg
| |.| |  ....|| . .       .|. . . . .||.| ||....  .| .     ..  .||| .||.....||.|.|. |||.  | ||||.   
knrypdilpydhsrvklsi.......lpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...

gPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQE--SYGPVVVHCSDGVGRTGLVIATDI
  |.. ||.. |||.   . ..| . || . |....  | |.|... .| |  .|.|.. |.... .|.. ..|  . |||.||||.||||||..|| ..
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

NMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
 ...||. ..||....|. .|. |..|. | .|| |.|. |.|.
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 705-937 9.3e-49 160.8 In-house 35-267 (270) alignment 
Range on Protein: 705-937
Range on HMM: 35-267/270.0
TRVPIpptsptsPSIPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGPGTQLYGNILV
||| .       ... ...   .. | ..||.|.....|| |      . ..|||..||.....|| .    | |.  | .|||.. .   .  .|.| |
tRvrl.......eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikv

TLKGGASGEHYFTSTLLIRnvEKSLCRPVTHYWFSNWLDSEIPSSPQ------ALMSMLLQVHNTHQES--YGPVVVHCSDGVGRTGLVIATDINMQRLE
.    .  | | .  | ..  ||.  | ..|.|. .| |  .|....       |..|| .|.....|    .|..||||.||||||..||.|| .. ||
lalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe

ESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFL
|.. ||. . .. .|.|| . .   .||.|.|... |. ...
etkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0045098 (Phosphotyrosine protein) phosphatases II 682-933 1.2e-48 161.3 In-house 25-271 (278) alignment 
Range on Protein: 682-933
Range on HMM: 25-271/278.0
IKKRIAVPVTSKPRSPVIQSPERTRVPipptsptspsipskpsDfFLDASFIRGYdssHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-K
|   . .   .| | . |.  ...||                 | ...||.|.||   .  .| .     .   .|||..||.....||.|.. .||| .
itpalylgnldknRykdilpydhsrVk................d.YINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

VCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV----EKSLCRPVTHYWFSNWLDSEIPSSP--QALMSMLLQVHNTHQE---------
 |.||||      |.. ||.. |||.     ..| . |||..|.    |   .| |||... .| | ..||.|  . . ..| .... ...         
kcaqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

----SYGPVVVHCSDGVGRTGLVIATDINMQRLeEsHTVDIPHTVSSIRQDRGQ-AILNIDQYAFIYRTLYEF
    | |||.|||| |||||| ..| .. ...| | ..||....|. .|. |.. |. | .|| |.|. |.|.
llldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 722-934 1.7e-48 160.3 In-house 72-280 (318) alignment 
Range on Protein: 722-934
Range on HMM: 72-280/318.0
KPSDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLL
. || ...|..| || ... .|| |     .  . ||| ||||.|..|| |    | ||. . .||| |    |.. ||.. |.||   . ..|   .. 
egsD.yinanyidGyrrkk.ayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk....gsrsygklvvelkeevelsdyvlrefk

IRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH-QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILN
... |..  | |  | . .| |. .|.|.  |.... ||.... ....||.||||| ||||||  || || ..|...  .||. .||. .|. |   .  
vtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

IDQYAFIYRTLYEFS
 ||| ||| .| |. 
edqyefiydvlleal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 659-938 5.3e-48 158.7 In-house 20-287 (319) alignment 
Range on Protein: 659-938
Range on HMM: 20-287/319.0
SYREAIAEEFENLPGHQLIassDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspSIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFW
.    ...||..| . .     ....       .| | . | . .|||| ..       ... ...  ...|||| ||.  .  .| .     .    ||
tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvls.......eldgvegsdyinasfidgyqere.kfiatqaPlentiedfW

RTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEggpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSL-CRPVTHYWFSNWLDSEIPSSPQALMSML
| |||..| ..| |.   | .|| . .|||...     . ||...|||.     |.|  . | ...    . .| |.|. . .| | ..| . ..|. .|
rmvWeeessivvmltklveklkvklkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

LQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFLS
 ........ . ||.|||||.||||||  |. |. ..|..|  ..|. .||| .|  |   . . .|| ||| .| |. .. .
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 725-933 2.3e-47 156.5 In-house 75-278 (288) alignment 
Range on Protein: 725-933
Range on HMM: 75-278/288.0
DFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGgpgTQLYGNILVTLKGGASGEHYFTSTLLIRn
  ...||.| |.....  || .     |.   ||. |.|... ||| | .  | ||  | .|||...     ..||.. |||..    |.. . .||.  
aDYinasyidgekkkk.kyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk...pknyGsvtvtlveskeledfvlrkllle.

vEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY
  |   . .|.| .  | | ..| | . |. .| ||....|.  ||..||||.||||||  || |  ....||. ..|.  ||. .|. | . . .  ||
.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqY

AFIYRTLYEF
 |||..| . 
efiyevllsl
subfamily_Ptp69D_pd Subfamily Ptp69D 663-937 6.4e-46 151.9 In-house 23-289 (307) alignment 
Range on Protein: 663-937
Range on HMM: 23-289/307.0
AIAEEFENLPGHQLIASSDIKKRIAvpVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVW
 .|.|.|.|. ..   |. . ..     . | |.. |.. ..||| ....  .      . || ...||||.||. .. ..| |          ||| ..
glakeyekLeareidkstkvsekke..nalknRyedikafDktRvkLkkingk......edsd.Yinasfikgykekk.kfiaaqdPveatigDfWRmia

EQQSRTIVCLCSPYELGKV-CPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKS-----LCRPVTHYWFSNWLDSEIPSSPQALMSML
||.. .|| |    |  .  |..|||       .. ||.|||.|    . ..|   .| . .....       | |. | . .| ||..| ....|. ..
eqevtlivmlsnlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

LQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFL
 ||.. .. . .|.||||| ||||.|...| |. .|.|.. ..||| .||  .|..|   . ...|| |.|| | ..|.. 
eqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
0037934 (Phosphotyrosine protein) phosphatases II 694-933 2.8e-45 150.1 In-house 14-241 (243) alignment 
Range on Protein: 694-933
Range on HMM: 14-241/243.0
PRSPVIQSPERTRVPIpptsptspsipskPSDFFLDASFIRGYDsshcSYIGATVSGGDSSTA----FWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPt
 | . |   ...|| .             ... ...|..|....     .|   .   ..       ||| .||.....||.|....|||.. |.|||| 
nrysdilpydhsrvkl.............egsdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

keggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVE-KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQE--------SYGPVVVHCSDGVG
     |.. ||.. |||..  ....|   |||..|.. . |.| |.||.. .| |  .|.||. |...| .|..  .|        | |||.|||| |||
.....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGLVIATDINMQRLeeshTVDIPHTVSSIRQDRGQ-AILNIDQYAFIYRTLYEF
|||..|| .. ...|    .||. ..|  .|. |.. |. . .|| |.|. |.|.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 722-933 3.6e-45 149.2 In-house 76-284 (293) alignment 
Range on Protein: 722-933
Range on HMM: 76-284/293.0
KPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpgTQLYGNILVTLKGGASGEHYFTSTLL
.... ...|..|.|| | .  .| .     ..   ||| |||..|..|| |    | ||| | .|||..|    ..|||.| |||.   . |.. . .|.
esgsDYinanyipgynspr.efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee...pvlyGdikvtlvaeeeledwvirelk

IRNveKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH--QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAIL
|..  .. .| |..| |  | | ..|.....|.... .|....  ..| .|.||||| ||||||  || |  .|..||. .|||  .|...|..| . . 
iek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvq

NIDQYAFIYRTLYEF
. .|| ||.... ..
tekqYifihqcvldl
subfamily_PTPRA_pd Subfamily PTPRA 661-934 3.3e-44 146.1 In-house 31-295 (330) alignment 
Range on Protein: 661-934
Range on HMM: 31-295/330.0
REAIAEEFENLPGHQLIASSDIKKRIAvpVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRT
 . . |||..||  .. |. .. ..       | | . |   . .|| ... . .      . || ...|||| ||   . ..| |     ..   ||| 
nklfreefnalPagpiqatlelaskee..nkeknrvvnilPydfsrvilsvkeGv......eesd.yinasfidGykekd.kfiaaqGPkeetvedfwrm

VWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEK----SLCRPVTHYWFSNWLDSEIPSSPQALMSM
.|||.| ||| |    |  .  | ||||..    |.  |||| |...     ..|    .|.... .       | |. . |  | |  .|. |. ....
iweqksativmltelkerkeekcaqywPde....GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkl

LLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFS
| .|....| | ||.||||| ||||||  |. |  ..|..  . ||. ..|...|. | | .    || |||..| |. 
lkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 666-933 2.5e-43 143.4 In-house 26-282 (305) alignment 
Range on Protein: 666-933
Range on HMM: 26-282/305.0
EEFENLPGHqlIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPtspsipskPSDfFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRTVWEQQ
.....|. .    | |..|. |   ... ...... ..|...   .. .         || ...||.. ||..... || |     .  . |||...| .
aqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld........dsd.yinasyvdgykrkkk.yivaqgPlkntvadfWrliveek

SRTIVCLCSPYELGK-VCPQYWPTKEGGPgtQLYGNILVTLKGGASGEHYFTSTLLIRN-VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH
 .||| |.   | ||  | ||||.... .  . .|.. |.||  .. . |..  | | .  |..  | |..| . .| |  .| .. .|.|.. .|....
vstivmltklveggkdkCrqYWpesktek..kefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq

QESYG-PVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
... | |..||||.||||||  || || ..||..  .||. . .  .|. | ... . ||| |..  | | 
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 724-933 1.2e-42 140.9 In-house 37-241 (250) alignment 
Range on Protein: 724-933
Range on HMM: 37-241/250.0
SDfFLDASFIRGYDSShCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEggpgTQLYGNILVTLKGGASGEHYFTSTLLIRN
|| ...|||. ||| .  ..| .     ..   ||| |.|..| ||| | .  | .|...||||...    .. ||...|.|.       | . .| . .
sd.yinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek....aekyGdvtvsllskeefadytkrklklsk

VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
 .|.  | | .. | .| |  .|   .| . .| .|. ..|.   .||.|.|| ||||.|  || |  ..||.....||. . .  .|.|| .|.   .|
akkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleq

YAFIYRTLYEF
| |.|. . ..
yvfvyeiilka
subfamily_PTPRG_pd Subfamily PTPRG 663-933 5.6e-42 138.7 In-house 20-286 (563) alignment 
Range on Protein: 663-933
Range on HMM: 20-286/563.0
AIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTsptsPSIPSKPsDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVW
 ..||||.|  .    . |...  .     | |   | . .|.|| . |.    | . .|  | .. |..| ||  |.  .|..  .  |    ||| .|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklspl....pgkkkkl.D.YinAnyidGyqksk.afiatqgplkdtfddFWrmiW

EQQSRTIVCLCS-PYELGKVCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRN--VEKS----LCRPVTHYWFSNWLDSEIPSSPQALMSM
||.. .|| .     .  . |..|||.     ... ||.. |||.       | . || |.|  ..|       . |..| ...| |   |...   ...
eqnvaiivmitnlvergrrkcdvYWPk....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif

LLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
  .   ....  ||.||||| ||||||  |. |  ...... ..|.. ...  ||  |   . ...|| |.. .| | 
vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 727-933 6.4e-42 138.8 In-house 86-289 (298) alignment 
Range on Protein: 727-933
Range on HMM: 86-289/298.0
FLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVE
.. |||. .|. .. ..| .      . . ||| |.|... ||| | .  ||.|  ...|||..    |.. ||.| |.|.   .   . . .| . . .
YiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde....gketygeitvsllskeefadlivrklkvskkk

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNtHQESYG--PVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY
..  | | .  |..| |  .|.  .... .| .|.  .|.  |  ||.|.||.||||.|  || |  ..|......||. ..|  .|..| .|.   .||
eekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

AFIYRTLYEF
.|||    |.
vfiyeavlea
subfamily_PTPN9_pd Subfamily PTPN9 721-935 5.8e-41 135.5 In-house 67-291 (297) alignment 
Range on Protein: 721-935
Range on HMM: 67-291/297.0
SKPSDfFLDASFIRGYDSsHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTL
 . || ...|.|. ||   . ..|..  .    .. ||| ||||. ..||      | |.. | ||||..|.   .. .|.. |.     . |.| ...|
deasd.yinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees..saefgdlsvsnveveeeedykvrvl

LIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH-------------QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTV
 |.||...  | |||. |  | |  .||| ..|. .| .| ..              . |  |.||||| |.||||  |. ||...||||  |||. .||
eiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetv

SSIRQDRGQAILNIDQYAFIYRTLYEFSK
. .|. |  .|   .||.| | .. |...
kllrtqrafsiqtpeqyefcylavleyal
subfamily_PTPN6_pd Subfamily PTPN6 662-935 6.8e-41 135.2 In-house 26-298 (306) alignment 
Range on Protein: 662-935
Range on HMM: 26-298/306.0
EAIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspsIPSKPSDFFLDASFIR-GYDSSHCSYIGATVSGGDSSTAFWRT
. . ||||.|  ..     . |.   .  ..| |   |   . ||| .          || | . ...|..|.    .|..||| .  .  .  . ||| 
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk........epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGgpGTQlYGNILVTLKGGASGEHYFTSTLLIR-NVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQ
||...|| || .   .| ||  | .|||..|    .. ||.| ||     | ..|   .|..  . .|. .| | .| | .| |  .|..|.|....| .
vwqensrvivmttkevErgkekCarYWPdeee..kee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VHNTHQESY----GPVVVHCSDGVGRTGLVIATDINMQRLEES---HTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
|.. ..|.     ||.|||||.|.|||| .| .|| .. .|..     .|| ..| |.|. | . .   .|| |.|... .. .
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_CG42327_pd Subfamily CG42327 862-937 7.5e-41 134.8 In-house 242-318 (319) alignment 
Range on Protein: 862-937
Range on HMM: 242-318/319.0
THQESYGPVVVHCSDGVGRTGLVIATDINMQRLEES-HTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFL
 ..||.||.||||||||||||||||.||....|||| ..||||..|||.|.||..|.|...||.|||..|.|..|.|
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_PTPN23_pd Subfamily PTPN23 662-930 8.5e-40 131.4 In-house 15-276 (288) alignment 
Range on Protein: 662-930
Range on HMM: 15-276/288.0
EAIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspsipsKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTV
 |. ..|..|  .|   . .    ||   ..| ||  |   ...|| .            .  | ...|||...  .   ..| .      ..  ||. |
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVH
.||.|..||.| |. ||||  . .|||...|   |. .|.. ||||   . |..   .| ..  ...  . |.|  . .| .  .|.||. |. .| .|.
yeqkssviVmllskeelgkpkvdrYwPedkge..tvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

N----THQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT-VDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
.    ....|  |.||||| ||||||..      .. ||. .  .||.. || .|..|   . . .|. | |   
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 645-932 9.1e-40 131.5 In-house 7-277 (315) alignment 
Range on Protein: 645-932
Range on HMM: 7-277/315.0
PSHTLTSNALAKFYSYREAIAEEFENLPGHQLIAsSDIKKRIAVpvTSKPRSPVIQSPERTRVPIPPTSptspsipSKPSDFFLDASFIRGYDSSHcSYI
|   | .    |  | .. . ...|..|| ||    |. |.|      | |   | . ...|| .| .         .|   ...|.|| ||.  .  ||
pldqlityvaqkkastkngfkqdyesipggqlhp.ldvakkien..kqknryiniiaydksrvqlplle.......ndphsdyvnanfidGynkkr.ryi

GATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFTSTLliRNVEKSLCRPVTHYWFSNWLDS
.|      |   ||| |.|..  .|| | .  |  |  . .||| |       .||.| ||.|     ..|   ||    | ..  | |  . .. | |.
aaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdm

EIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
..| .  .|| .  .|.  |..| |..|||||.||||||  |. |  ....|  . .|. . .  .|| | ...  ..|| ||| .| |
gvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 695-932 1.5e-38 127.6 In-house 46-274 (281) alignment 
Range on Protein: 695-932
Range on HMM: 46-274/281.0
RSPVIQSPERTRVPIPPTSPTSpsipskPSDfFLDASFIRGYDSShCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgp
|   | . . ||| . |.. ..       .| ...|.|. ||..    || .     .| .|||. ||||. ..|| .    | ||. | .||| ..   
rYsnivaYDatrvkvtpneenk......ntD.Yinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns..

gTQLYGNILVTLKGGASGEHYFTSTLLIrNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESY-GPVVVHCSDGVGRTGLVIATDINMQ
 .  ||.. |. .  .. ..| . .. . . |..  | |..  . .| |  .|.....|..   .|.......   |.|.||| ||||||  || |  ..
.elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvk

RLEES-HTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
..|.. ...|.  .| ..|..|   .  . ||.|.|... .
aveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_PTPN12_pd Subfamily PTPN12 724-933 9.1e-38 124.8 In-house 67-276 (290) alignment 
Range on Protein: 724-933
Range on HMM: 67-276/290.0
SDFFLDASFIRGYDSsHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpGTQLYGNILVTLKGGAS-GEHYFTSTLLI
 . ...|.||.| .. ...|| |     .  . ||| .||.. . .| .|  .||||  | .||| . .   .  .|.. |||.      . ..  || .
gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege..eelefgefevtleeekavdddflirtLkv

RNVekSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT---VDIPHTVSSIRQDRGQAIL
..   . .| |. . . .| | ..|||.. |.... .|.......  |.||||| |||||| .|| |.  . |.. ..   .|. . | ..|..|  .. 
eaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq

NIDQYAFIYRTLYEF
  .|| ..|... |.
tkeqyelvykavael
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 719-932 3.3e-37 122.8 In-house 65-274 (515) alignment 
Range on Protein: 719-932
Range on HMM: 65-274/515.0
IPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTS
|  .|   ...||.|...|. . .|| .      |   ||| |....  ||. .    |  |. | .||| | |   .  .|.| | |    .       
indnPhsdyfnasyipsfdndk.ayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd..svkfGsikvelvsleactggikr

TLLIRNVEKslCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAI
.| .   ..  .| || . | .| |  .|   ..|. .. .|   |..   |...||| ||||||.||. |  . . .....||. ..|  |||.| . .
kltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylv

LNIDQYAFIYRTLYE
   .|||||| .. |
qtqeqyafiygavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 724-936 1.4e-36 121.5 In-house 89-293 (319) alignment 
Range on Protein: 724-936
Range on HMM: 89-293/319.0
SDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCspyelGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRN
|| ...|||. || .    || |     ..   ||| .||... ||| |       . | |||| |    . . ...  | ..     . |    . . .
sd.yinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplk....ivikeerfkvkvdsveetaeyvvrdielse

-VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQES--YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNI
  ..   | .| . |  | |   | .|  || .. .|.  ..      ..||||| ||||||  |. |. ..|..| . ||. ..|  .||.| . . ..
dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

DQYAFIYRTLYEFSKF
 || ||| .| |   |
vqykfiysalleehlf
subfamily_PTPN3_pd Subfamily PTPN3 743-930 2.1e-36 120.3 In-house 86-271 (280) alignment 
Range on Protein: 743-930
Range on HMM: 86-271/280.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWL
|| .     ...| ||. ||||.|..|| | .  | |.| | ||||..|    .. ||.. |...  .. . | .  |.... |..  |....  . .| 
yiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete...deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp

DSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
|...|.... ..... .|..... .  ||||||| |.||||..|. .. .. .|... | ... |. .|. |.  . . .|| |.  ..
dhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 719-933 2.3e-36 120.2 In-house 66-276 (315) alignment 
Range on Protein: 719-933
Range on HMM: 66-276/315.0
IPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTS
|  .| . ...||.|...|. . .|| .      |   ||| |....  ||| .    |  |  | |||| ...   .  .|.| |.|    .     . 
iddsPdsdyinasyiksvdddk.ayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad..svefGsikvellsleadtdgvar

TLLIRNVEKSlcRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAI
 | .|. |.|  | || . | .| |  ..    .|. .. .|   ...   ...|||| ||||||.||. |  .........||. ..|  .|..| . .
klvtrksees..rtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylv

LNIDQYAFIYRTLYEF
   ..||||| .. | 
qteeeyafiydavled
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 724-936 2.7e-36 120.5 In-house 53-257 (284) alignment 
Range on Protein: 724-936
Range on HMM: 53-257/284.0
SDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCspyelGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRN
|| ...|||| || . .  || .     ..   ||| .||... ||| |       . | |||| |    . . ...  | ..     | |    . . .
sd.yinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplk....ivikeerfkvkvdsveeseeyvvrdielse

-VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQES--YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNI
  ..   | .. . |  | |   | .|  || .. .|.  ..      ..||||| ||||||  |. |. ..|..| . ||. ..|  .||.| . . ..
dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

DQYAFIYRTLYEFSKF
 || ||| .| |   |
vqykfiysalleehlf
subfamily_PTPN13_pd Subfamily PTPN13 727-932 2.8e-36 120.2 In-house 62-267 (273) alignment 
Range on Protein: 727-932
Range on HMM: 62-267/273.0
FLDASFIRG-YDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPgTQLYGNILVTLKGGASGEHYFTSTLLIRNV
...||.|.   .  . .|| .     .. . ||. ||||... |. . .  | ||| | .||| ... . ..... . |.| .    . .  ..| ....
yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk.lkvsnrlevellkvqkldgfvvralavkds

EKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQeSYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYA
| .  | |.|  | .| | ..|||.. |. .. .| . .. . ||.||||| |.||.| .|. |. .. .|  . .|. ..| ..|. |   .   ||| 
esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyi

FIYRTLYE
|.|... |
fvykaile
subfamily_PTPRK_pd Subfamily PTPRK 718-932 5.1e-36 119.1 In-house 64-275 (314) alignment 
Range on Protein: 718-932
Range on HMM: 64-275/314.0
SIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFT
.|   ||  ...|..| .|  ..  .| .     .  . ||| |..... .|| |    | |.| | .||| .     |. ||.| |.|      . . .
tidgdpssdyinaalidsykrpa.afivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.....tevygdikvelvetellaelvv

STLLIRNVEK--SLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRG
 .. ......  .  | | .. | .| | ..| | ..|.... .|.....|. |..||||| | ||||  || || .. .|. ..||. ..| ..|. . 
rifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkv

QAILNIDQYAFIYRTLYE
  .   .|| |||  . |
nmveteeqykfiydvile
subfamily_PTPN14_pd Subfamily PTPN14 727-933 2.2e-35 117.1 In-house 78-295 (300) alignment 
Range on Protein: 727-933
Range on HMM: 78-295/300.0
FLDASFIRG-YDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV
...|| |.    ... ||| |        . ||. ||||. . || | .  | ||  . .|.| .|    |  .|.  || |   . . . |..| .. .
yinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl

EKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH---------QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
  .  | | |  . .| | ..|. ..  .| | .|.            .||  ||.||||.|||||| .| .|. .. ||  ...||..... .|. |  
pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrml

AILNIDQYAFIYRTLYEF
 . .. || |.|..| ..
lvqtlaqYkfvYkvliky
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 726-932 4.4e-35 116.0 In-house 77-281 (290) alignment 
Range on Protein: 726-932
Range on HMM: 77-281/290.0
FFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNV
 ...|..| ||  .. .|| .     .    ||. .|....  || |..  | || .| ||||..    .|. ||.. ..|    . ..| . .| ..| 
eyinAcyikgykekk.qyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds....dtkaygefsikllneetlneyierklevknk

EK-SLCRPVTHYWFSNWLDSE-IPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
..   .. ||.| ..|| . . ..     |...  .... ...  ...||||||.|||... .|... ... .    .|. . . | |. . . .   .|
nsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq

YAFIYRTLYE
| .|.. . .
yqgifqivlt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 719-933 1.4e-34 114.6 In-house 73-283 (297) alignment 
Range on Protein: 719-933
Range on HMM: 73-283/297.0
IPSKPSDFFLDASFIRGYDSshcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTST
. ..|.  ...|||..|.      .|  .    ..   ||. |...|  ||| |    |  | | .||. |    |.. .|.. |.|.  .. | .   .
vnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk....gvttfGdvsvvllsvsereGfikre

LLIRNVEKSLCRPVTHYWFSNWLDSEIPS--SPQALMSMLLQVHNTHQES-YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
| ... .    | |  | | .| | ...   | ..|. .. .|......   ||..|||. ||||||.... |  . . .. ..|||  .|. .||.| .
levtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpy

AILNIDQYAFIYRTLYEF
 .   .||.|.| .. |.
lvqtkeqykfvyvavlea
subfamily_PTPRN_pd Subfamily PTPRN 722-930 2.8e-33 109.9 In-house 81-288 (297) alignment 
Range on Protein: 722-930
Range on HMM: 81-288/297.0
KPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkEggpGTQLYGNILVTLKG-GASGEHYFTSTL
. ......||.|   |  . .|| .     .. ..||..|||| .  || |..  | | | | .|||  |   |...|.   | |       . |.  ..
aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd.e...Gsevyhiyevhlvsehiwcddylvrsf

LIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEE-SHTVDIPHTVSSIRQDRGQAIL
 ..|...|  | || . |  | ....|.|...|. .  .|  ...    |.|||||||.||||  |. |. ..||    . .||  |.  .|..| . . 
ylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvk

NIDQYAFIYRTL
  ||. |.. ..
tkdqfefaltav
0036282 (Phosphotyrosine protein) phosphatases II 730-928 5.4e-33 109.5 In-house 7-164 (174) alignment 
Range on Protein: 730-928
Range on HMM: 7-164/174.0
ASFIRGYDSSHCSYIGATVSGgdsstaFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkeggpgtqlygnilvtlkggasgehyftstllirnVEKSL
||.. ..  .   ..|.          ||. ..|....|.|.|....|||   |..|||.                                     ..|
aspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe...................................lredl

CRPVTHYWFSNWLDSEIPSSPQaLMSMLLQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDINMQRLEeSHTVDIPHTVSSIRQDRGQAILNIDQYAFIY
 | . .|.. .| | . |.... | ... .|.. ..| . |||.|||| ||||||...| .. ...|. . .||. ..| ..|. |.... . .|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

R
 
y
0051429 (Phosphotyrosine protein) phosphatases II 741-936 6.7e-33 109.9 In-house 9-227 (272) alignment 
Range on Protein: 741-936
Range on HMM: 9-227/272.0
CSYIGAT-------------VSGGDSSTAFWRTvWEQQSRTIVCLCSPYELGKVC-PQYWP--------TKEGGPGTQLYGNILVTLKGGASGEHYFTST
 ...|                    .   |||  .|.. .|||.|.|..|.|..  ..|||        . . .. | |||.. |||      ..|   .
ardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilre

LLIRNV-EKSLCRPVTHYWFSNWLDSEIPSSPqaLMSMLLQVHNthqesYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVD--------IPHTVSSI
||....   .  | |.|... .|.|  .|...  | ..| ....      |||.|||| |..|||.|.| .. .......  ||        . ..|. .
llltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

RQDRGQAILNIDQYAFIYRTLYEFSKF
|. | .|. . .||.|.|. | |. . 
raqrpgavqteeqylflyeallellrs
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 718-936 9.1e-33 108.3 In-house 69-281 (439) alignment 
Range on Protein: 718-936
Range on HMM: 69-281/439.0
SIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKvcpqYWPTKEggpgTQLYGNILVTLKGGASGEHYFTS
 ||  |   ...| .|.||   .  || . .   ...  ||| |.|... ||| |.   |  |    |||...       ||.| |         .|   
eipgvphshyinanyikGyyddk.lyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsda....evcygdiavrvdrnielpnyvir

TLLIRNVE--KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT-HQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRG
 . . |        | | .. .  | | ..|.    .. .|  .  .  .| ||||||||| |||||| .|| || ...|     |||   |. .|..| 
gfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrk

QAILNIDQYAFIYRTLYEFSKF
| . .. || ||| .. |  ..
qmvqalcqyvfiynavledivy
subfamily_CG7180_pd Subfamily CG7180 721-933 1.2e-32 107.8 In-house 66-289 (296) alignment 
Range on Protein: 721-933
Range on HMM: 66-289/296.0
SKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEggpgTQLYGNILVTLKGGASGEHYFTSTLL
 . .. ...|... ..   .  ||       ..  .||| |..... ..| |. . .  | .|.||| |      . ||.|.| .    .  .  . |. 
GeeksdYinavyvdsflkkk.eyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks....keqygeifveiveekqyanlkirtfk

IRNV----------EKSLCRPVTHYWFSNWLD-SEIPSSPQALMSMLLQVHNTHQ-----ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPH
.             .|   | |... .  |    ..|.| .||. .. .|.   .     . .|||||..|||..|.|  .| |.|.. .|. . ||. .
ltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFe

TVSSIRQDRGQAILNIDQYAFIYRTLYEF
 |  .|..| | . |...| .|| .| |.
avktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 722-931 2.3e-31 103.7 In-house 55-263 (283) alignment 
Range on Protein: 722-931
Range on HMM: 55-263/283.0
KPSdFFLDASFIR--GYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYE-LGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTST
..   ...|.||     .     || |     .    ||. |....  .|| |    | | . | |||| .    |.. ||.  |||.   . . .    
esr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr....GsedyGeftvtlrkettsnsfiike

LLIRNV---EKSLCrpVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
||.|.    ...|   ..|| . .||. .  .   .|. . . . .  ..  ||.||||| |.|||.  ||    .. .  .  ||.. .|  .|..|  
lllrvnssakstll..lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmm

AILNIDQYAFIYRTLY
|. . ||| ...    
avqtldqyklvhelvl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 706-932 5.5e-31 102.6 In-house 63-276 (287) alignment 
Range on Protein: 706-932
Range on HMM: 63-276/287.0
RVPIPptsptspsipSKPSDfFLDASFIRGYDSsHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGgpgtQLYGNILVT
||..            .  | ...|.|| || . .  .| |     .    ||. .....  .|| ||   |   .|| ||||...      ..|.  ..
rvllk..........gehpd.yinavfidgyke.kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks....vvlGeynie

LKGGASGEHYFTSTLLIRNVEK-SLCRPVTHYWFSNWLDSE-IPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDI
|      ..|   .| ..| .| .  . |. | . || .   ...    |. .  .... .... ...||||||.|||... .| .. ... ..  ..|.
llneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDv

PHTVSSIRQDRGQAILNIDQYAFIYRTLYE
   . | |. . ...  ..|| ||.  . |
fqvlksqriqkpgsvqtveqykfindivle
subfamily_PTPN1_pd Subfamily PTPN1 738-939 1.4e-30 101.0 In-house 68-276 (290) alignment 
Range on Protein: 738-939
Range on HMM: 68-276/290.0
SSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLY-GNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHY
  . ||| .     .  . ||. ||||.|...| |    | ... | ||||..|     .|   .. |.|    . ..|  ..| . |..   .| ..|.
eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhf

WFSNWLDSEIPSSPQALMSMLLQVHNTH--QESYGPVVVHCSDGVGRTGLVIATDINM---QRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
 .  | |  .|.||.|....| .| ..   .. .||.|.||| |.||.| ..  |  .   .. ..  .||| ...  .|. |   |   ||  | | ..
hyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

YEFSKFLSS
 | .|.. .
leGakvikg
0046846 (Phosphotyrosine protein) phosphatases II 743-933 2.1e-30 101.2 In-house 14-172 (176) alignment 
Range on Protein: 743-933
Range on HMM: 14-172/176.0
YIGATVSGGD-----------SSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGtqlygnilvtlkggasgehyftstllirnvekslcr
|| | .  |.           .  .|.. ..|.. ...|.|....|||.. ||.|||  |.                                       
yinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................

pvtHYWFSNWLDSEIPSSpQALMSMLLQVHNTHQESyGPVVVHCSDGVGRTGLVIATDinmqRLEESHTVDIPHTVSSIRQDRG-QAILNIDQYAFIYRT
   .|.. .| |  .|.. ..|...| ....  .|  |||.|||| |.||||...| .     || .. ... .... .|. |  .|. . .|| |.|. 
...qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef

LYEF
....
elll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 723-930 2.2e-30 100.6 In-house 33-236 (239) alignment 
Range on Protein: 723-930
Range on HMM: 33-236/239.0
PSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYEL-GKVCPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFTSTLLI
|   ...||..| || |  .|| .  .   ||  ||| .|...   || |    |   | | ||||       |  | |. |||.       |   |...
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....tskycnlrvtlrktevfadyiirtfvm

RNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNID
 .| ..  | | .| |. | |  .|    |.. .  .. .       | |.||| |||||| ..  |  ... .. .||||   | .||.|| . .   .
sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QYAFIYRTL
|| ||. ..
qyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 723-930 2.6e-30 100.4 In-house 34-237 (239) alignment 
Range on Protein: 723-930
Range on HMM: 34-237/239.0
PSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYEL-GKVCPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFTSTLLI
|   ...||..| || |  .|| .  .   ||  ||| .|...   || |    |   | | ||||       |  | |. |||.       |   |...
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....tskycnlrvtlrktevfadyiirtfvm

RNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNID
 .| ..  | | .| |. | |  .|    |.. .  .. .       | |.||| |||||| ..  |  ... .. .||||   | .||.|| . .   .
sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QYAFIYRTL
|| ||. ..
qyvfihlav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 727-932 3.9e-30 99.8 In-house 31-237 (237) alignment 
Range on Protein: 727-932
Range on HMM: 31-237/237.0
FLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGgPgtQLYGNILVTLKGGASGEHYFTSTLLI-RNV
...|....|.| .  .|| |      |   ||. ||...   || |    |  .  | .|||  .  |  . || . |.||       |   .||. ...
yinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.p..aaygvltvslkkkeefsdytvrslllskrl

EKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT--HQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
..   | .  | |. | |  .|    ||. .  .. |   |    || ..||| ||||||...  |  ... .| . |||   | || .||   |   ||
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

YAFIYRTLYE
| ||..|. |
yvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 730-935 6.5e-30 99.5 In-house 24-172 (182) alignment 
Range on Protein: 730-935
Range on HMM: 24-172/182.0
ASFIRGYDSSHCsYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCspyelgkvCPQYWPtkeggpgtqlygnilvtlkggasgehyftstllirnveKSLC
|....|.  .   .| . .   ..  .|.|...|.. .|||.|.        ...|||                                      . | 
anlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt........eelywp......................................elle

RPVTHYWFSNWLDSEIPSsPQALMSMLLQVHNthqeSYGPVVVHCSDGVGRTGLVIATDINMQRleeshTVDIPHTVSSIRQDRGQAILNIDQYAFIYRT
| ...|.. .| | ..|. .. | ... .|..    . |||.|||| |||||| ..| .. ...      |.....|. .|. | ... . .|| |... 
rlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqla

LYEFSK
|.|. .
llelll
PTPc_DSPc_SM00012 832-931 6.5e-30 98.8 In-house 2-104 (105) alignment 
Range on Protein: 832-931
Range on HMM: 2-104/105.0
VTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESY--GPVVVHCSDGVGRTGLVIATDINMQRLEES-HTVDIPHTVSSIRQDRGQAILNIDQYAFIYR
|.||....| | ..|.........| .|.. ...|.  .|||||||.|||||| ..| || .|.||.. ..|||  .|...|. | ... . .|| |.||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLY
 | 
all
0049260 (Phosphotyrosine protein) phosphatases II 743-927 5.2e-29 96.3 In-house 11-143 (152) alignment 
Range on Protein: 743-927
Range on HMM: 11-143/152.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWptkeggpgtqlygnilvtlkggasgehyftstllirnvekslcrpvtHYWFSNWL
.|..   |. .   ||| ..|.. .|||.|....||||. |.||.                                               .| . .| 
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpwp

DSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMqrleesHTVDIPHTVSSIRQDRGQAILNIDQYAFIY
|.  |...| |. .|| ..   ... |||.|||| ||||||...| .. .      . |.. ..|. .|. | .|. | .|. |.|
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 722-933 2.5e-28 94.2 In-house 73-287 (325) alignment 
Range on Protein: 722-933
Range on HMM: 73-287/325.0
KPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLI
.||  ...||..| .      .. | .   ..   .|| | . ..  .| |    .  . | .||| . |   .. .| . | |.       |    | .
dpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgk..sktfGglevklrtieeisdyvhrvldv

RNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ------ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
..|.|   | |  . .  | |   .  | .|.|.|  |.. ..      .. .|..||||.||||||  |.    .... |   |||   |  .|.|| .
kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrps

AILNIDQYAFIYRTLYEF
 .  .||| .|| .| |.
mvetvdqyiliyealvea
0043147 (Phosphotyrosine protein) phosphatases II 727-927 1.8e-27 91.5 In-house 7-154 (172) alignment 
Range on Protein: 727-927
Range on HMM: 7-154/172.0
FLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPyelgkvcpqywptkeggpgtqlygnilvtlkggasgehyftstlliRNVEK
. .||.. .|    ...|     ..     ||| ..|.. ..||.|..                                                .  .
yinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydpe

SLCRPVTHYWFSNWLDSEIPsSPQALMSMLLQVHN-THQESYGPVVVHCSDGVGRTGLVIATDINMqrleesHTVDIPHTVSSIRQDRGQAILNIDQYAF
 |.| . .|.. .| |   | ... |...| ....  .... |||.|||| ||||||...| .. .      . ... ..|. .|. |..|. | .|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IY
.|
ly
0051082 (Phosphotyrosine protein) phosphatases II 728-932 4e-27 90.1 In-house 6-151 (151) alignment 
Range on Protein: 728-932
Range on HMM: 6-151/151.0
LDASFIRGYdsshcSYIGATVsggdsSTAFWRTVWEQQSRTIVCLCSPYELGkVCPQYWPTKEggpgtqlygnilvtlkggasgehyftstllirnveks
...|.. |.      |...       . .|.....|.. .|||.|.|..| |  ||.|.|  .                                     
infsyvtgg.....lyrsggp.....ladflellkelgiktivnlrseeerg.ycpeylpelg.....................................

lcRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNthqESYGPVVVHCSDGVGRTGLVIATDINMQRleeshtVDIPHTVSSIRQDRGQAILNIDQYAFIY
  . |.|... .| |  .| |..|....| .. .    . |||.|||| |.||||...| .. ...      |..  ... .|. |. ..   .|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

RTLYE
. |.|
falle
0044763 (Phosphotyrosine protein) phosphatases II 710-929 6.1e-27 89.8 In-house 3-166 (178) alignment 
Range on Protein: 710-929
Range on HMM: 3-166/178.0
PPTSPTSPSIPSKPSDFFLDASFIRGYdsshcSYIGATVSggdssTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGgpgtqlygnilvtlkgg
..|    ....  .. ....||.| ..      |.|.  .      .... ..|.  ..||.|....|||   |..|||...|                 
drtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

asgehyftstllirnvekslcrpvTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRleeshTVDIPHTVSS
                         .| . .. |.  |.... .. ..  ... ..|. |||.|||| ||||.|...| .. ...      ..... .. 
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

IRQDRGqAILNIDQYAFIYRT
.|. |  .. | .|. ..|. 
vrerRp.ivpnpgqlrqLyef
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 665-932 2.2e-25 83.9 In-house 23-234 (392) alignment 
Range on Protein: 665-932
Range on HMM: 23-234/392.0
AEEFENLPGHQLIASSDIKKRIAVPvtsKPRSPVIQSPERTRVPIPptsptspSIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQ
.||| .||| ..   .  .| | ..   | |   |   ...|| .         |   | . .|.||.|...|. . .|| .      |   ||| |...
feefhdlpgpdiypqtvaqkeinlk...knryknilpydsarvkle.......viddipdsdylnasyipsfdnek.ayiasqgpnaaslddfwrmvfqe

QSRTIVCLCSPYELGkvcpqywptkeggpgtqlygnilvtlkggasgehyftstllirnvEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ
.  ||. .    |                                                   .| |. . |..| |...|    .|. .. .|.  . 
nvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG

ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
.   |...||| ||||||.||. |  . . .... ||.   |. ||. |   .   .|||||| .. |
qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 728-933 1.2e-24 81.5 In-house 84-282 (290) alignment 
Range on Protein: 728-933
Range on HMM: 84-282/290.0
LDASFIRGYDSSHCSYIGATvsgGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTqlYGNILVTLKG-GASGEHYFTSTLLIRNVE
. | ...| ..      ||.    |.   .|| | ...  .|| ||   | ||  | ||.| |||   |  .|.| |.        ..    || .|...
vhanyvkGlkamfiltqGal...kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt..fGeitvlcseeddkdaniikktlsvrdkd

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNthqeSYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAF
.     . |.    | |  .. |  ||. .|  . .      |||||||| |.||||  .| .. .| | . . .|.  .| ..|. | ...    ||  
sGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla

IYRTLYEF
. . | ..
lveilldl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 727-933 1.2e-23 78.3 In-house 72-292 (301) alignment 
Range on Protein: 727-933
Range on HMM: 72-292/301.0
FLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGG-----------------
...||.| || ...  .| |        . ||| .|...  .|| ..   |  |  | ||||. |    .. .|.. |||.                   
yinasyidgysekk.kfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae..seefgpftvtlvneqvyPdfvirqlnvkiqd

ASGEHYFTSTLLIRNVEksLCRPVTHYWFSNWLDSEI-PSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVS
.|.. |. ... ...      . |. .   .| .  . .     |...  ..| ... . |||||||||.|.|.|  .. .| .        ||.   . 
gsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtk

SIRQDRGQAILNIDQYAFIYRTLYEF
..|. .  |.  ..|| .||  . ..
avrrskpgaVtTLeqytsiydvidmy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 743-928 1.1e-22 75.2 In-house 7-198 (199) alignment 
Range on Protein: 743-928
Range on HMM: 7-198/199.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE--KSLCRPVTHYWFSN
|| .  .  .. . ||. |||  |  || .       .   | |||| | |  |  ||.. || |  ..   |  ..|.. |        | ..|| |. 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WLDSEIPSSPQALMSML--LQV-HNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT--VDIPHTVSSIRQDRGQAILNIDQYAFIYR
| .   |     .  ..   .| ..  ||   ||.|||||| | ||. .| || ..  |||.|  ||.      .|| |   |  ...| |||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 743-928 1.1e-22 75.2 In-house 6-197 (198) alignment 
Range on Protein: 743-928
Range on HMM: 6-197/198.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE--KSLCRPVTHYWFSN
|| .  .  .. . ||. |||  |  || .       .   | |||| | |  |  ||.. || |  ..   |  ..|.. |        | ..|| |. 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WLDSEIPSSPQALMSML--LQV-HNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT--VDIPHTVSSIRQDRGQAILNIDQYAFIYR
| .   |     .  ..   .| ..  ||   ||.|||||| | ||. .| || ..  |||.|  ||.      .|| |   |  ...| |||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 743-933 5.2e-22 73.2 In-house 84-276 (307) alignment 
Range on Protein: 743-933
Range on HMM: 84-276/307.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTqlYGNILVTLK---GG----ASGEHYFTSTLlIRNVEKSLCRPVTH
.| |     ..   ||  . ...  ... ||   ||.|. | |||| .||   .  .|.   |.     |    |  |..   |  .. .  . .| ..|
ficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv..fgeapntisvanlgakklapdedlinvtt.lkvdwaqksrtiqh

YWFSNWLDSEIPSSPQALMSMLlQVHNTHQesyGPVVVHCSDGVGRTGLVIATDINMQRL-EESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
. ..|| |  .|    . . .| .  . ..    ||||||| ||||.| ..|  . .... .     |. . |  .|..|  || .  || ...| | |.
lqwenwpdrgvpqinltainll.eavrydt...npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 727-933 1.4e-21 71.5 In-house 67-276 (287) alignment 
Range on Protein: 727-933
Range on HMM: 67-276/287.0
FLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeGGPgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE
...| .. .|   . ..| |      .   ||| |.|..| ... .    | ..  | .||| .   |  .. |  .| |.      .| . .| . ..|
yinanyvasytdde.afiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evP.mrvGGysvvlldydikePeygvralrlidle

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQV--H---NTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNI
   .| |  . . .| |  .. .  .|. . |.|  |   .   .  ||.|||.. |.||.|...|| . ..|||.   ||.  .|  .|. |   .  .
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

DQYAFIYRTLYEF
 |. ..| .|  .
vqlrllyealvty
0048076 (Phosphotyrosine protein) phosphatases II 796-930 1.9e-21 71.7 In-house 11-139 (145) alignment 
Range on Protein: 796-930
Range on HMM: 11-139/145.0
QLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESyGPVVVHCSDGVGRTGLVIATDINMQrle
  .|.. ..|.     .. .|  | . . .. | | ...|.. .| | ..|.... |...| .... ..|  |||.|||| ||||||...| .. ..   
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...

esHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
  . |......  .|. | .|. | .|. |.|. .
..lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 729-933 4.2e-21 69.9 In-house 84-288 (305) alignment 
Range on Protein: 729-933
Range on HMM: 84-288/305.0
DASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEK-
 | ..      .  .| |     ..   ||  | ...   || ||   ||||. | ||||.  |   .   | ..  . |    |      . . |.   
hanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys

-SLCRPVTHYWFSNWLDSEIPssPQALMSmlLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT-VDIPHTVSSIRQDRGQAILNIDQYA
 .    | |  ...| |  .|  |  | |  |..  . . |  |.||||| |.|||| ..| .  .... | .    .|. | ..|..|  .| |  || 
gdqkmsvrhlqwtewpdrgvp..pcklts..lellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqyl

FIYRTLYEF
||.| . ..
fihrvmlny
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 665-934 8.5e-21 68.8 In-house 14-269 (281) alignment 
Range on Protein: 665-934
Range on HMM: 14-269/281.0
AEEFENLPGHqliASSDIKKRIAVPVTSK-PRSPVIQSPERTRVPIpptsptSPSIPSKPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWE
 .|| ||||      ||.   .  ||  |  |   |   . .|| .         .| | |  .. | .||     .  || .     .. . ||| .|.
kqefsnlpgd...ppsdlctvfnqpvnnkknrylnipcldisrvql......kvkmpnknstdyihanyirsp.flkrgyiltqgpkketradfwrmiwq

QQSRTIVCLCSPYELGK-VCPQYWPTKEGgpGTQLYGNILVTLKGGASGEHYFTSTLLIrNVEkSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT
... .|| ||   |  .  | .|.| .        . .. |. .  .  .   |. | .   |    | .||. . .| | ..| | . .. .| ...  
enttaivmlcqfletnrekcaeyfprnah..cclqfdklsvsyedstvnkslvttrlnl.sye.getrlithwlwkewpdwqvpessevmlkilrkirar

hqeSyGPVVVHCSDGVGRTGLVIATDINMQRLEESHTV-DIPHTVSSIRQ-DRGQAILNIDQYAFIYRTLYEFS
   |  | |.||| ||||.| ..| .| .| .    |. || . || .|   |  ..  ..|| .|.. | .| 
...s.tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
0049772 (Phosphotyrosine protein) phosphatases II 716-937 1.3e-20 69.8 In-house 64-283 (314) alignment 
Range on Protein: 716-937
Range on HMM: 64-283/314.0
SPSIPSKPSDfFLDASFIRGYdsshCSYIGATVSGGDSSTAF----------WRTV--WEQQSRTIVC---------------------LCSPYELGkvc
 |. | . || . .||...|.    ...| .          |          || |  .....|.||.                     |... ..|   
lpglpvsgsd.yinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...

pqywptkeggpgT----------QlygnilvtlkggasgehyftstllirNVE---KSLCRPVTHYWFSNWLDSEIPsSPQALMSMLLQVHNThqESYGP
                       .                          ..    . . |.. .|.  .. | . | ... . ..|  ...   .  ||
............neptaadlellk..........................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggp

VVVHCSDGVGRTG--LVIATDINMQrleeshTVDIPHTVSSIRQDRG-----QAILNIDQYAFIYRTLYEFSKFL
|.|||..|.||||  .|.|  .  .       |..  ... .|. |       .| . .|| ||.. |.|. |||
vlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
0048179 (Phosphotyrosine protein) phosphatases II 763-928 6.4e-20 66.8 In-house 27-139 (144) alignment 
Range on Protein: 763-928
Range on HMM: 27-139/144.0
EQQSRTIVCLCSPYELGKVCPQywptkeggpgtqlygnilvtlkggasgehyftstllirnvekslcrpVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT
... .|...|...||   . ..                                               ...|.. .| | ..|.... | ..|  ... 
klgittvinlteeyepeflere...............................................giqylhlpwpDhgvpdllellleflefieea

HQESyGPVVVHCSDGVGRTGLVIATDINMqrleeSHTVDIPHTVSSIRQDRGQAILNIDQYAFIYR
..|. |||.|||| ||||||...| .. .      . ... ...  .|. | .|. | .|. |...
leeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 753-935 3.3e-19 63.4 In-house 105-286 (302) alignment 
Range on Protein: 753-935
Range on HMM: 105-286/302.0
SSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEGGpgTQLYGNILVTLKGGA--SGEH-YFTSTLLIRNVEKSLCRPVTHywFSNWLDSEIPSSP
|   ||| |....  ..| |  . || |   ...|.| |    . ||.. |  .     ..|.  ..  .|  ..  |.   |..  ..|| ....| . 
sveeFWrmvfqekivsvvilvgeeelkktlselfpkksgd..ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv..ltnWkqkkvpvky

QALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
 .|.    .|.. ....  ..|.    |.|| | ...  . ...|.... . |  .| |||..| .|. ...||...|..|  . |
aeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 725-935 6.7e-19 62.9 In-house 58-260 (267) alignment 
Range on Protein: 725-935
Range on HMM: 58-260/267.0
DfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWrTVWEQQSRTIVCLCSPYELGKVcPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNV
. ...||.. ||   .  .|    .   . | |. ||. .|  ... |  .   ... ...|| | |   .. | .. |        . |   || ..  
e.yinasyvegyktkn.afivtqdplkntitdfl.tvihdqkvpvivlltkvftdni.rlfwPPkmgq..akkyqdltvehslekeendyqiitlelkfk

EKSlCRPVTHYWFSNWlDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYA
..| .. || |.. .| . .    |     . .  .|  ..   |.||.|||||||.|  .  |  ..|. .  ..|| . .  ||. |   .   ..| 
nes.ahnvtlyyykkw.nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryi

FIYRTLYEFSK
.|...| |...
yihellaeyae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 743-934 2.9e-18 60.7 In-house 90-287 (305) alignment 
Range on Protein: 743-934
Range on HMM: 90-287/305.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYF--------TSTLLIRNVEKSLCRPVT
.| .     .. . ||   ....  .|  ||   | | | | .|...|..   .   ..  ...|  .|..  |        | | |. .   .  | ||
fictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvt

HYWFSNWLDSEIPSSPQALMSMLLQVhnthQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVD-IPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
|| . .| |  .|.. .|.. .| .     . | ||.||||| |.|||| |.  .  ...| . . ..   . .  ||..| ..|   .|| |... . .
hyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

FS
. 
yf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 756-928 2e-17 58.3 In-house 82-253 (290) alignment 
Range on Protein: 756-928
Range on HMM: 82-253/290.0
AFWRTVWEQQSRTIVCLCSPYELGK-----VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRnVEKSLCRPVTHYWFSNWLDSEIPSSPQ
 || .. . ... .| ||   |  .      | .| |...|.     .... |  |     .   | .|...  ..     |||.....| ..... ...
kfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge..elkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtk

ALMSMLLQVHnthqESYGPVVVHCSDGVGRTGLVIATDINMQRLE-ESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYR
 |.|.. .|.     |  ||.||| ||. |   . | .. .| .   |. | .   ....|. | .|| .  ..||.  
tllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 756-932 2.1e-17 58.1 In-house 97-269 (288) alignment 
Range on Protein: 756-932
Range on HMM: 97-269/288.0
AFWRTVWEQQSRTIVCLCSPYELGKVCP-QYWPTKEGgPGTQLYGNILVTLKGGASGEHYFTSTLlIRNVEKSLCR-PVTHYWFSNWLDSEIPSSPQALM
 .|. . |.. . || ||   |.||    .|.|.| |   ...  .  |. |  |  ..  . .| .|. ..   .  | .  . .| |  .| . .. .
elWkmllesdveyivmlcellekGkeksaeyfPsklG.ekarigrlctvvkkkradidklvkvsl.lriskegeekvivkilhlleWdddgvPenylspl

SMLLQVHNTHQesygPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
 .|  ......    |.|||.| |||||| .| . | .. |  .  . |.. ... |..| .||    || ...| ..|
rllevlkslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 755-933 5.7e-17 56.6 In-house 42-220 (255) alignment 
Range on Protein: 755-933
Range on HMM: 42-220/255.0
TAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALM
 .|..|.  ... ..| ||  .| |.. | .|.|..    . . . .. ||    ..     | ...    ||   . |.|| .  |..   |  .. ..
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekd..eklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

SMLLQVHNthqeSyGPVVVHCSDGVGRTGLVIATDINMQ----RLEESHTVDIPH--TVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|  |..    |  .|||||| |.||.   . ...  |     |....||.. .   .  .|. | .|| .  | ||   .. ..
nilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 753-932 4.7e-16 53.4 In-house 102-280 (301) alignment 
Range on Protein: 753-932
Range on HMM: 102-280/301.0
SSTAFWRTVWEQQSRTIVCLCSPYE-LGKVCPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSL-CRPVTHYWFSNWLDSEIPSSPQ
.|  ||  .   .  .|| |.   | | ..| .| |.| .        .| .. |     ..    || ...  . .  | |||| .|.| | ..| |  
tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksha

ALMSMLlqvhNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY-AFIYRTLYE
 |. ..    .  ..|  |.|||||.|.||.   |.|..  ...|   |... ...  .|..| ... .  |       |.| 
elfdlm....elvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyr
subfamily_ptpA1_pd Subfamily ptpA1 727-896 1.4e-15 52.0 In-house 77-258 (418) alignment 
Range on Protein: 727-896
Range on HMM: 77-258/418.0
FLDASFIRGYDSshCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLYGNILVtLKGGASGEHY-----FTSTLL
...| .| |       .| .     .. . ||| |||.. | || |    |  .. | .||| . ||    .|||    . |  | |           ..
yinanyidgayp..kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngne.vfgtysvelveviqdpereii

IRNVE---KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ------ESYGPVVVHCSDGVGRTGLVIATDINMQRLEE
 ||.    .   | .|.| .  | | .||   | .  .|  . | ..      .   |..|||| |||||| . .. | |..|. 
trnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 829-932 2.8e-15 50.6 In-house 88-192 (440) alignment 
Range on Protein: 829-932
Range on HMM: 88-192/440.0
CRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ-ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIY
.| . .| .  | |  .|     .. |. .| ....  . ||..|||| |.||||..|| |  ..  . |  .||   ..|.|..| | .   .||||..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

RTLYE
 .. |
eavle
subfamily_egg_pd Subfamily egg 691-940 3.1e-15 50.6 In-house 41-276 (307) alignment 
Range on Protein: 691-940
Range on HMM: 41-276/307.0
TSKPRSPVIQSPERTRVPIpptsptspSIP-SKPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELgKVCPQYWPTK
  | ||. ..  . .|| .         ..  . .| |. |  ..|       .| |     ..   ||| |.... . || | |  |  . |. |||  
lekarskrvhckdssrvkl........elrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpka

EGGPGTQLYGNILVT-LKGGASGEHYFTSTLLIRnVEKSLCRPVTHYWFSNWLDSEIPSSPqalmsmlLQVHNTHQESYGPVVVHCSDGVGRTGLVIATD
|  .   . |.. .. ||     .  |. | |   |          .|  ..  |    ||       |.|    ..   ||||.. .|| ... ..| .
esdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqgdvnnssdvysp.......lrvlrklrnlskpvvvqdilGvskaatlvaie

INMQRLEESHTV--DIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFLSSS
| .  |    ..   . ..|  .|. |  ..  . .| |.|| .  | . . .|
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 727-933 2.8e-14 47.7 In-house 61-269 (285) alignment 
Range on Protein: 727-933
Range on HMM: 61-269/285.0
FLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGPGT-QLYGNILVTLKGGASGEHYFtSTLLIRNV
.. ||..|     . .|| .     .. . ||. .....   .. ||. .| | . |  |.| | |       |   |   |  |     .  .| . | 
yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtil.naltvint

EKSLCRPV--THYWFSNWLDSEIPSSPQALMSMLLQVHNTHQeSYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
| .   |.   |     | |   |   . .. .   |..       |..|||| |||||  ..  |    |. |   ...   |  .|  | ||. .  |
edasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmq

YAFIYRTLYEF
. |.|  | |.
flflyvvlmey
subfamily_hpo-7_pd Subfamily hpo-7 756-933 8e-14 46.2 In-house 49-226 (263) alignment 
Range on Protein: 756-933
Range on HMM: 49-226/263.0
AFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpGTQLYGNILVTLKGGASgEHYFTSTLLIRNVE-KSLCRPVTHYWFSNWLDSEIPSSPQALM
.|..|.  ... ..| ||  .| |.. | .|.|..    . | . |. |.     | .    .  |. ... |   . |.|| .  |.. . |  ..  .
kfyqtivqtktevvvmLcDfneegvekcssyfPlekd..ekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelareil

SMLLQVhnthQESyGPVVVHCSDGVGRTGLVIATDINMQ----RLEESHTVDIPH--TVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|  .    ..|  ..||||| |.||.     ...  |     |....||.. .   .  .|. | .|| .  | ||   .. .|
nilkva....rns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 756-935 2.2e-13 44.5 In-house 109-291 (310) alignment 
Range on Protein: 756-935
Range on HMM: 109-291/310.0
AFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeGgpGTQLYGNILVTLKGGASGEHYF---TSTLLIRNVEKS-----L-CRPVTHYWFSNWLDSEI
 ||| ...... .|. ||   | |.  |  |||.  |   |. || | ||  . .| |      . |..  ||        |    |.   . || |  .
dfwrmifqeraesilllckvgeegrpkcvgywpsl.g..vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgv

PSSPQALMSMLLQvhntHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
|      .   |      |  .||.||||| |..|...|.| ......|.. . ||. . .. ....| . | .  || .| |    |..
pdekchtvpqrll....aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 751-949 3.2e-11 37.5 In-house 92-288 (312) alignment 
Range on Protein: 751-949
Range on HMM: 92-288/312.0
GDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGG---PGTQLYGNILVTLKGGASGEHYFTSTLLiRNVEKSLC--RPVTHYWFSNWLDSE
 ...| ||. .    | .|. ||.  | |   | .|     |       ..| .    .. |       |  .| . | |.      . || .. | |  
entcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvl.kvvvkatgqesklnhyqwaswpdhg

IPSSPQALMSMLLQVHNTHQesygPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFskfLSSSGTKE
.| | .. . .|  |.. ..    ||. ||| |||||| ..  .  .  |      .. ..   .|.|| ...  . || .  |.. ||   | | |  .
mpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef...lyskglyk

TSDTE
 .. |
rneqe
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 871-933 3.5e-11 37.3 In-house 2-64 (69) alignment 
Range on Protein: 871-933
Range on HMM: 2-64/69.0
VVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
||||| | ||||  ||  ..| |.     |||   |  .|. |   ..|  .| ||. .| | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 871-933 5.5e-11 36.7 In-house 1-63 (69) alignment 
Range on Protein: 871-933
Range on HMM: 1-63/69.0
VVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
||||| | ||||  ||  ..| |.     |||   |  .|. |   ..| ..| ||. .| | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 867-929 1.3e-10 35.6 In-house 228-290 (297) alignment 
Range on Protein: 867-929
Range on HMM: 228-290/297.0
YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRT
  ...|||| ||||.|.|. .|. ...|   .  |.   .| .|. | . .  ..|. ..|  
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 824-926 1e-09 32.3 In-house 182-280 (302) alignment 
Range on Protein: 824-926
Range on HMM: 182-280/302.0
VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLlQVHNTHQESygpVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY
..| . ..|    || | |   |  ... . .| .  ......   |.|||| |||||| ..|    .|   . .. |. . |  .|| |  |. . .| 
kkkkvkktvdilafsawpdhGapkeaytaldil.kfcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

AFI
 ..
iyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 832-932 1.1e-09 32.5 In-house 217-342 (350) alignment 
Range on Protein: 832-932
Range on HMM: 217-342/350.0
VTHYWFSNWLDSEIPSSPQALMSMLL---------QVHNTHQ-ESYGPVVVHCSDGVGRTGLVIATDINMQ---R----LEESHTVD--------IPHTV
| .  . ||.|. .   |. ....|            ..  . .   |..|||| |||||| ... |  ..         .||. .|        |  .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SSIRQDRGQAILNIDQYAFIYRTLYE
  .|. | . . |.||. ||| .|  
nelrkqrismvqnldqfifiYeallf
subfamily_CDKN3_pd Subfamily CDKN3 842-937 3e-07 24.2 In-house 109-199 (202) alignment 
Range on Protein: 842-937
Range on HMM: 109-199/202.0
DSEIPSsPQALMSMLLQVHnTHQESYGPVVVHCSDGVGRTGLVIATDINMqrLeeSHTVDIPHTVSSIRQDRG-QAILNIDQYAFIYRTLYEFSKFL
|  .|. . . . .| ... .  ..|   .|||  |.||. ||||  . .  |  . |..  ......|. .| .||  . || ..       ...|
dglvpd.iasclkileelr.inlkayrktlvhcygglgrsslviacllly..l..ddtiepkdaidklrdlkgsraiqtvkqynylsefrdkleeyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 741-855 3.5e-07 24.4 In-house 76-189 (297) alignment 
Range on Protein: 741-855
Range on HMM: 76-189/297.0
CSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEhYFTSTL-LIRNVEKSLCRPVTHYWFS
  || |     ..   ||. |.||. |.|| ..   | |.  |  |||  ...   .  |...|      | | . .  |  .. . .|  | |.|  | 
lkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe..rlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqfl

NWLDSEIPSSPQALMSM
.| |  .||  . |  .
swpdhGvpsdledlvrf
subfamily_PTPDC1_pd Subfamily PTPDC1 831-938 7.4e-07 23.8 In-house 82-176 (182) alignment 
Range on Protein: 831-938
Range on HMM: 82-176/182.0
PVTHYWFsNWLDSEIPSsPQALMSMLLQVHNTHQESygPVVVHCSDGVGRTGLVIATDINMqrleeSHTVDIPHTVSSIRQDRGQAILNIDQYafiyRTL
 ...| |  | | . .|  . .. .   |. . ||    | |||  | ||||..||. .       .. ..  .... .|. | ..|   .|     ...
giyvynf.gwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqv....elv

YEFSKFLS
 ||..||.
kefalfli
0038934 (Phosphotyrosine protein) phosphatases II 841-929 1.1e-06 23.9 In-house 88-172 (194) alignment 
Range on Protein: 841-929
Range on HMM: 88-172/194.0
LDSEIPSSPQALMSMLLQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDInmqrlEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRT
 |   . | . |.. |  |.  ..| . | |.|||  |.||||...|  .      ...  .    .  .|. |. || |.|..  ... 
pddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 839-933 6.5e-06 19.7 In-house 227-343 (349) alignment 
Range on Protein: 839-933
Range on HMM: 227-343/349.0
NWLDSEIPSSPQALMSMLLqVH-----------NTHQESYGPVVVHCSDGVGRTGLVIATDINMQ--RLE--ESHTVD--------IPHTVSSIRQDRGQ
||||. .   |....  |  |              ...   ...|||| | |||| ..  |. ..       ||  ..        |  .| ..|. | .
nwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqris

AILNIDQYAFIYRTLYEF
 . |. |. .|| .| ..
mvqnlaqfiaiyealLky