Gene SpurPTP-sf1-19 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP051_AA protein Get Run
SpurP051_AA_119-398 phosphatase_domain Get Run
SpurP051_AA_410-582 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 119-579 2e-138 457.5 In-house 5-460 (564) alignment 
Range on Protein: 119-579
Range on HMM: 5-460/564.0
ISLDEFTKYVHTNR--QSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKK
|. .|. ..|.  .  ..|.. ||.. .   ...... |. ..||.|||| ||..|..|||||. .. |. |||||||.||    .|     |  .||..
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkay...IAtqgPla

NTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGaDETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFL
.|..|||||.|....... |.|||||  |.||..|||..|  |||||..|. ...||    ..|.|.. |  |...|. ..|.||.|||. ||...  .|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

RYMREVKKTYlADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQE
. .|.|...   .|. |..||||||.||.|. |..|...|..|  ..|.. ..|.|.|. |. |||| |||.|.|||.|| | | .| .... .. .||.
dlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LTKQDPKGGQTLLDQEFKTLSKISPDPsPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPfGDYINASFVKSMGNDSSpyYIVTQMPLPETVV
|...... ..| |..||. |.  .... .    .. | . ||||| | .|..|..| .|.   ..|   ||||||....  .  .  .| || || .|| 
LaeveedtemtgleleFqrLatakeie.leefavatkpknkkknrfsnilalescrvvlsairakee.sdyinasyleayrekra..fiatqaplkntve

NFWSLVYDYKPTTIVMLNQLDK-TDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
.|| .|.... ..||||..|..  ...  .|..| .. .|| .||. .. .... ...|  .|. 
dfwrmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvev
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 119-476 1.3e-102 338.5 In-house 2-355 (515) alignment 
Range on Protein: 119-476
Range on HMM: 2-355/515.0
ISLDEFTKYVHTNRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDV-NPDHKFvlptISHKGPKKN
. | .|  .|  ||.   . |||  ||| |    | |. | | .||||.|||||...|| ||||.|.| |||.|||||   . |. .    |. .||.| 
lplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkay....iasqgPnka

TVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAD-ETYGEIHVEAKSTEERDFGVLREFIIFKASEdKRKLTHFQFTKWPDKSVPKQTSLFLR
.||||||...||..  . |||||.|  | ||  ||||  .|   .|.|.||  |.|    |. |.. . | ..  | .| |.||.|||| |||.|| .|.
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllk

YMREVKKTYLADDsAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQEL
...|||         ||..|||||.|| ||.|..|||| .|| |  |.|  ||. .|. |  .|||.||| |...|||| |   .| |||  |   ||.|
likevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

TKQDPKGGQTLLDQEFKTLSKISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQS
       |.. . .||.||  . |||     |.|   . . ||| .. ||..||| ||.|
hssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvilds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 118-410 1.7e-92 304.7 In-house 9-297 (297) alignment 
Range on Protein: 118-410
Range on HMM: 9-297/297.0
GISLDEFTKYVHTNRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDhkfvlPTISHKGPKKN
 | | .|. .| .||..    |||  ||  |. . | |.   | .|.||.|||||. ||| |....||| |||.|||.. .|         |... |.|.
piplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.....rlittqmPmka

TVDDFWRMIWQEKIRVVSMVTKLEEVLKtKCECYWPDSGADEtYGEIHVEAKSTEERDFGVLREFIIFKAS-EDKRKLTHFQFTKWPDKSVPK--QTSLF
||.|||.|...|.. .. |.....|  | ||  ||.|.|  . .|.. |. .|..||  .. ||. . | .   .| .  .||..||||.|..  ..| .
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl

LRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFE
| .. ||.|..    ..||||||.||.|| |||...|||| .|||. .|.. |.|. .|. | ..|||.||| |...|||| |...||||... ||
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 119-435 5.1e-92 303.1 In-house 3-315 (315) alignment 
Range on Protein: 119-435
Range on HMM: 3-315/315.0
ISLDEFTKYVHTNRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNT
| . .|  .|  ||..  . |||  ||. .. . . |. ..| .||||.||||....||.||||||.| |||||||||    | |     |. .||.| .
ipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkay...iasqgPlkas

VDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGADE-TYGEIHVEAKSTEERDFGVLREFiIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRY
|||||||..|||.  . ||||..|  | ||  ||||  ||   .|.|.||  |.|    || |.. . . ||..|..| ||||.|||| |.|||| .|..
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllkl

MREVKKTyLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELT
..|||      .  .||||||||.||.||.|..|.||.|.|||  |.|  ||. .|. |  .|||.|.| |...|||| |   .| |.|  |  .||.| 
ikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

KQDPKGGQTLLDQEFKTL
      |.. . .||.||
tsvdgsgrskmtkefetl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 120-435 3.1e-87 287.6 In-house 3-318 (318) alignment 
Range on Protein: 120-435
Range on HMM: 3-318/318.0
SLDEFTKYVHTNR--QSLELIEEFEAL-PGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKK
|.... . |.  |   .|.| ||.|.| .  .|   . .  . || |||| |||.|...|| |. ..... ||||||.||| .  .|     |. ..|  
svedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkay...iaaqaPlp

NTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAdETYGEIHVEAKSTEERDFGVLREFIIFKA-SEDKRKLTHFQFTKWPDKSVPKQTSLFL
.|..|||||.|. . .|. |.|..||  |.|.. |||..|. ..||...||.|.. | .  ||||| . .  .|..|.   ...|.|||..||.... .|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasll

RYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQE
  .|.|.|. .  .  |..||||||.|| || ||.|...|..|  . |.|...|. .|| |. ||||..||.|.....|| | . || .  . .  |..|
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LTKQDPKGGQTLLDQEFKTL
|..|||. |.| .| ||. |
lreqdpesgttemdaefqrl
subfamily_PTPRB_pd Subfamily PTPRB 117-397 6.4e-87 286.3 In-house 5-285 (293) alignment 
Range on Protein: 117-397
Range on HMM: 5-285/293.0
TGISLDEFTKYVHTNR--QSLELIEEFEALPGVNTE-QVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIdvnPDHKFVLPTISHKG
. |.|..|...|....  . |.. ||.| |  |... .|. |.|..|. ||||.|||||..||| |. ..|.. ||||||.||   |...     |. .|
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi...pgynsprefiatqG

PKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFKaSEDKRKLTHFQFTKWPDKSVPKQTSL
|  .||||||||.|..| ... |.|.| |  |.||| |||.   . .||.|.|. ...|| .  |.||. | | ....||.....|| |||  ||..|. 
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektkt

FLRYMREVKKTY-LADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
.|...|.|...   . ...|..||||||.||.|..||.| .... ...  |.. |.|...|| |...||| .||.|.|..||. |
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 127-433 6.4e-86 283.3 In-house 16-319 (319) alignment 
Range on Protein: 127-433
Range on HMM: 16-319/319.0
YVHTnRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVLPTishKGPKKNTVDDFWRMI
 ...   .  | .||. | . ...... |. ||||.||||.|||.|...||||  .|. . |||||||.||   ...  . |   ..|..||..|||||.
alas.tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiat...qaPlentiedfWrmv

WQEKIRVVSMVTKLEEVLKTKCECYWPDSgADETYGEIHVEAKSTEERDFGVLREFIIFKASEDK--RKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKT
|.|.. .| |.||| | || |.. |||.    |.||.. |. .. || .  . |.. . |.|..   |...|||.|.|||. ||... . |  .....|.
Weeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

YLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTKQDPKGG
    .| |. ||||||.|| |  |..| ..|. |. | ..|. .|. .|  |. |||. ||| |..||.|| . . || | |. .. ||..|...... |
rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtg

QTLLDQEFK
.| |..||.
etglerefq
0050432 (Phosphotyrosine protein) phosphatases II 106-399 1.5e-85 282.6 In-house 13-301 (308) alignment 
Range on Protein: 106-399
Range on HMM: 13-301/308.0
NYEKSTLTSKPTGISLDEFTKYVHTNRQSLELIEEFEALPGVNT-EQVTYAKLEENKPKNRYRNILPYNNSRVVLeviddDPYSDYINASYIDVNPdHKF
 . . ... . . .|.... |..    ..  | ||||.|. | . .. ..|.|.|||.||||..|||| .|||.|     |. ||||||||.|.   .|.
lfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgys.skl

VLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDS--GADETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTK
    |  .||..|||.|||||.|....||. |.|||.|  . ||. |||..  |  ..|| ..|. .|.|..|  ..|.... .  ... |..|||..| 
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytn

WPDKSVPKQTSLFLRYMREVKKTYladDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVC
||| .|| ... .|.....|.|..   .. | .||||||.||.|..||.| ..|| ...|.|.| . |. .||.| .|||| |||.||..|.|| | .
WpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 117-396 5.8e-85 280.5 In-house 3-285 (288) alignment 
Range on Protein: 117-396
Range on HMM: 3-285/288.0
TGISLDEFTKYVHT--NRQSLELIEEFEALPGVN-TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFvlpTISHKG
| ||..|..|.|..   ..   |.||||.|. .. . ....|.|.||..||||..||||..|||.| |.|... ||||||||||. .  .     |  .|
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk...fIatqg

PKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDsGADETYGEIHVEAKSTEERDFGVLREFIIFK-----ASEDKRKLTHFQFTKWPDKSVP
|..|||.|||||.|....||. |.|||.|  ..||. |||. |  .|||.|.|. .|.|. |  ..|.... .      .. .|. |||..|.||| .||
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

KQTSLFLRYMREVKKTYLaDDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
  ..|.|...|.|.| .  ... | .||||||.||.|..||.| ..|| ...|.|.| ..|. .||.| .|||| |||.|..||.|| 
dspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 131-436 1.5e-84 279.3 In-house 15-315 (317) alignment 
Range on Protein: 131-436
Range on HMM: 15-315/317.0
NRQsLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEK
.     | |||| |. .. .  ..|.|.|||.||||..|||| .|||.| ... |. ||||||||.|.    .     |  .||..|||.|||||.|...
sdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk...fIatqgPlpntvedFwrmvweqg

IRVVSMVTKLEEVLKTKCECYWPDsGADETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLaDD
..|. |.|.|||  . ||. |||. |   |||...|. .|.|| .  .||.. . .  ....|..|||..| ||| .||. ..|.|. ...|.. .  |.
vtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dp

SAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTKQDPKGGQTLLD
. |.|||||||.||.|..||.. ..|| ...|.|.|   |. .||.| ..||| |||.||..|.|| | . .|..|.  . ..|..|.  .. .. .| .
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklke

QEFKTLS
.|.|.|.
kelklll
0046845 (Phosphotyrosine protein) phosphatases II 137-401 1.6e-83 275.7 In-house 2-278 (284) alignment 
Range on Protein: 137-401
Range on HMM: 2-278/284.0
LIEEFEALPGVNTE---QVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDD-PYSDYINASYIDVN--PDHKFVLPTISHKGPKKNTVDDFWRMIWQEK
|.||||.|. ...    ....|.|.||. ||||..||||..|||.| ..|.| . ||||||||.|.   . ...    |  .||..|||.|||||.|...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IRVVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFKA--SEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLA-
.||. |.|.|.|  ..||. |||..|   |||...|. .|.|..|  ..|.. . .   ..  |..|||..|.||| .|| ... .|...|.|.. . . 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

DDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTG---KVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDD
... | .||||||.||.|..||.| . || ...|   .|.| . |. .||.| .|||| |||.|..||.|| | .  
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 128-404 1.6e-82 272.1 In-house 20-297 (298) alignment 
Range on Protein: 128-404
Range on HMM: 20-297/298.0
VHTNRQSLELIEEFEALPGVNT----EQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKfvlPTISHKGPKKNTVDDFW
|. . .   . .||. |  |.     |. . |. .||| |||| .|.... |||||| .|.|  |||||||...   ...   . |  ..| ..|| |||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn...afiatqaPltetvedFW

RMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAdETYGEIHVEAKSTEERDFGVLREFIIFKAS-EDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVK
||...|.| .. |.|.|||. |||.. ||||.|. ||||||.|. .|.||    . |.... |.. |..|.. ...||.||||.||....  | ..|.|.
rmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

KTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRI
..      .|..|.||||.||||  ||.|||.|..|.  .| |.  |...|. | ..||| |||||..||||| | . .. |
asqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0039614 (Phosphotyrosine protein) phosphatases II 107-397 1.7e-81 269.2 In-house 4-289 (297) alignment 
Range on Protein: 107-397
Range on HMM: 4-289/297.0
YEKSTLTSKPTGISLDEFTKYVHTNRQSLELIEEFEALPGVNTEqVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDD-DPYSDYINASYIDVNPD-HKf
.....|.| |...|  .. . ...  ..  |..||| |. .. .  ..|.|.|||.||||..||||..|||.| ..|. |. ||||||||.|.     . 
lrdallesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr.

vlPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKtKCECYWPDSGAdeTYGEIHVEAKSTEERDFGVLREFIIFKaSEDKRKLTHFQFTKWPD
    |  .|| ..||.|||||.|.....|. |.|||.|  . ||. |||..|   |||...|. ...|..|  ..|.. . . ..  |..||||.|.|||
..kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpd

KSVPKQTSLFLRYMREVKKTYLAD-DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
 .||  ..|.|. ...|.. . .. .. | |||||||.||.|..||.. ..|| ...|.|.|   |. .||.| ..|||..||.||..|.|| |
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 139-409 9.3e-81 266.7 In-house 18-289 (297) alignment 
Range on Protein: 139-409
Range on HMM: 18-289/297.0
EEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLevidDDPYSDYINASYIDVNpdhKFVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVT
|  | ||  .    ..|.|.||..||||..||||...||.|    ||. ||||||||.|.    ..    |  .||..|||.|||||.|.....|. |.|
efeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgy...dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

KLEEVLKTKCECYWPDS-GADETYGEIHVEAKSTEE--RDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLAD-DSAPL
.|.|  . ||. |||.  |   |||...|. .|.|.   |  .||.. . .  ....|..|||..|.||| .||  .. .|.....|.| . .  .. | 
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

LVHCSAGIGRSGVLIAMDSVVEQAK---RTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGF
|||||||.||||..||.| ...| .   ..|.|..  .|. .||.| ..||| |||.||.||.|| | . .|..|....
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 132-395 4.1e-80 263.9 In-house 18-277 (288) alignment 
Range on Protein: 132-395
Range on HMM: 18-277/288.0
RQSLELIEEFEALPGVN-TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEK
|.  .. ||...|. .. |..|| ..| .|..||||||||||.  || |.  .. . .|||||||||..  .|     |. .||  .||.|||......|
rnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkky...iatqgPladtvndfWelvyenk

IRVVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFKAsEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdS
.  . |.|.| |  ||||| ||||..  . ||.. |......| .  |||.... |  ......|..|.. |||..||...  .| ..| || .  || .
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk.kteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

APLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
 |..||||||.||.|. ||.| .... ... ...| |.|. .|. |...||| .||.|..|..|.
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0043336 (Phosphotyrosine protein) phosphatases II 136-395 5.5e-80 264.1 In-house 21-275 (278) alignment 
Range on Protein: 136-395
Range on HMM: 21-275/278.0
ELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVnpdHKFVLPTISHKGPKKNTVDDFWRMIWQEKIRVVS
 |..||| |. ....  ..|.|.|||.||||..||||..|||.|.... |. ||||||||.|.   ...    |  .|| ..||.|||||.|....... 
llllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg...ynvprkfiatqgPlpetvedFwrmvwelgvttiv

MVTKLEEVLKTKCECYWPdsGADETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLaDDSAPLL
|.|.|.|  ..||  |||  |  .|||...|. ...|. |  ..| . . .  .  .|. ||.....||| .|| ..||.|.....|.. .  |.. |.|
mLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvl

VHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
||||||.||.|..||.. ..||....|.|...  |. .||.| ..|||..||.||.||.||
VHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 134-434 2e-79 261.7 In-house 21-314 (314) alignment 
Range on Protein: 134-434
Range on HMM: 21-314/314.0
SLELIEEFEALPGVnteqVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKfvlPTISHKGPKKNTVDDFWRMIWQEKIRV
.  . ||.|.|.         || .||. |||. .||.|..|||.| .||.|| ||||||..||     .     |  .||...|| ||||....|.   
gygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpa...afivtqgPlqetvkdfWrlvydencas

VSMVTKLEEVLKTKCECYWPDSGADetYGEIHVEAKSTEERDFGVLREFIIFK---ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLAdDS
. |.|.| || . ||  |||. .    ||.|.||  .||     | | | . |   . |..|.. .|||..|||  ||..   .|...|.|||.    . 
ivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.ea

APLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTKQDPKGGQTLLDQ
 ...|||||| ||.|. ||.|.|.. ..| | |.|.  |...|. . |||.| |||.|.....||. .| .| |||  |.    | .. ||.   . | .
GrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlke

EFKT
||.|
efqt
DSPc_SM00195 139-395 3.9e-79 261.0 In-house 4-260 (263) alignment 
Range on Protein: 139-395
Range on HMM: 4-260/263.0
EEFEALPGVN-TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVN-PDHKFvlptISHKGPKKNTVDDFWRMIWQEKIRVVSM
|||| |   . ....| |. ..|| ||||.|||||...|| |. ..... ||||||.||... ...|.    |   ||...||.|||||.|.||.... |
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkky....IatQgPlpstvedFWrmvweekvkiivm

VTKLEEVLKTKCECYWPDS-GADETYGEIHVEAKSTEERD-FGVLREFIIFKAS-EDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdSAPL
.|. ||  |.||. |||.. |  ||.|.|.|. ...|...   .||.. . |   |..||.|..|...|||..||..|. .|...|.|||..    |.|.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.||||||.||.|.....|..... ... ||..   |...|. | .||||.||| |..||.||
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 139-395 3.9e-79 261.0 In-house 4-260 (263) alignment 
Range on Protein: 139-395
Range on HMM: 4-260/263.0
EEFEALPGVN-TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVN-PDHKFvlptISHKGPKKNTVDDFWRMIWQEKIRVVSM
|||| |   . ....| |. ..|| ||||.|||||...|| |. ..... ||||||.||... ...|.    |   ||...||.|||||.|.||.... |
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkky....IatQgPlpstvedFWrmvweekvkiivm

VTKLEEVLKTKCECYWPDS-GADETYGEIHVEAKSTEERD-FGVLREFIIFKAS-EDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdSAPL
.|. ||  |.||. |||.. |  ||.|.|.|. ...|...   .||.. . |   |..||.|..|...|||..||..|. .|...|.|||..    |.|.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.||||||.||.|.....|..... ... ||..   |...|. | .||||.||| |..||.||
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPRA_pd Subfamily PTPRA 134-432 8.1e-79 259.9 In-house 31-330 (330) alignment 
Range on Protein: 134-432
Range on HMM: 31-330/330.0
SLELIEEFEALPGVNT-EQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIR
.  . |||.|||  .    .  |. |||| |||. |||||. |||.| |..  ..|||||||.||   . .     |. .|||..||.|||||||. |  
nklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkf...iaaqGPkeetvedfwrmiweqksa

VVSMVTKLEEVLKTKCECYWPDSGAdETYGEIHVEAKSTEERDFGVLREFIIFKA-----SEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLA
 . |.|.|.|  ..||. |||| |.  |||.|.|| . ...     .|.|.. .       ...| .. | || |||  || ..   |.....|||.   
tivmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq

DDSaPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTKQDPKGGQTL
  . |. ||||||.||.| .|..|.|.|. |  .||.|..||. .|  | .||||||||.|.....||  .  || . |  .| .||.| .. ..  .. 
sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkig

LDQEF
|..||
leeef
0047943 (Phosphotyrosine protein) phosphatases II 127-395 8.9e-79 260.1 In-house 4-270 (273) alignment 
Range on Protein: 127-395
Range on HMM: 4-270/273.0
YVHTNRQSLELIEEFEALPGVNTEQ-VTYAKLEENKPKNRYRNILPYNNSRVVLevidDDPYSDYINASYIDVNPDHKFvlpTISHKGPKKNTVDDFWRM
....  ..  |.||||.|. . ..   ..|.|.||| ||||..||||..|||.|    .|. ||||||||.|. .  .     |  .||..|||.|||||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk...fiatqgPlpntvedfwrm

IWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA--DETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVK
.|....||. |.|.|.|  . ||. |||..|    .|||...|. .|.|..|  ..|.... .  ....|. |||..|.||| .|| ... .|.....|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

KTYLAD-DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
|.. |. .. | .||||||.||.|..||.| ...| ...|.|.|   |. .|..| .|||| |||.||.||.||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 119-418 5.8e-78 257.1 In-house 4-304 (305) alignment 
Range on Protein: 119-418
Range on HMM: 4-304/305.0
ISLDEFTKYVHTNR--QSLELIEEFEALPGVnTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKK
|.||....|.. .|  .. .| .....|.    |..   | |.|| |||...| .....|. |   .... ||||||||.|    .|     |  .|| |
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkky...ivaqgPlk

NTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAD-ETYGEIHVEAKSTEERDFGVLREFIIFK--ASEDKRKLTHFQFTKWPDKSVPKQTSL
|||.||||.|..||.... |.||| |  | ||. |||.| .. . .||..|| ||...    . |.. | .   ....| ....|.|.|||. ||.... 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

FLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRL
.|. ...|.|..  |   |||||||||.||.|| ||.|  .|..|. . |.| . ....|. | .|||| .||||||.|. | . | || | .. ...|.
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QELTK
. | |
nklkk
0045450 (Phosphotyrosine protein) phosphatases II 130-395 2.7e-77 255.8 In-house 22-302 (307) alignment 
Range on Protein: 130-395
Range on HMM: 22-302/307.0
TNRQSLELIEEFEALPGVNTE---QVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDD-PYSDYINASYIDVN-----PDHKFVLPTISHKGPKKNTVD
.      | .||| |. |...     ..|.|.|||.||||..||||...||.| ..|.. . ||||||||..|.     . ... .  |  .||...||.
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

DFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFK--ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYM
|||||.|.....|. |.|.|.|  . ||  ||||.|   |||...|. .|.|. |  ..| . .     ..  |..|||..|.||| .||. .. .|. .
dFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi

REVKKTYLAD-DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGK---VNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.||.| . .. .. | |||||||.||.|..||.. . .| ...|.   |..   |. .||.| ..||. |||.||.||.||
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 119-435 4.7e-76 250.7 In-house 4-274 (392) alignment 
Range on Protein: 119-435
Range on HMM: 4-274/392.0
ISLDEFTKYVHTNRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYID-VNPDHKFvlptISHKGPKKN
|   .|  .|. ||.|  ..|||  ||| .  . | |. | |..||||.|||||...||.|||||| | |||.|||||. .. .. .    |. .||.  
ipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekay....iasqgpnaa

TVDDFWRMIWQEKIRVVSMVTKLEEVLktkcecywpdsgadetygeihveaksteerdfgvlrefiifkASEDKRKLTHFQFTKWPDKSVPKQTSLFLRY
..||||||..||..  ..|||||.|                                              .|.|  . |.||.|||| |||.|| .|..
slddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkf

MREVKKTYlADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELT
..|||  .  . . ||..|||||.||.||.|..|||| .||.|  |.|  ||  .|. |  ||||.||| |.. |||| |.  .| |||  |  .||.| 
ikevkadf.Gqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

KQDPKGGQTLLDQEFKTL
      ...   .||..|
tssdGdvrskqlkefrsl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 119-432 2.6e-74 245.0 In-house 6-314 (315) alignment 
Range on Protein: 119-432
Range on HMM: 6-314/315.0
ISLDEFTKYVHTNRQSLE--LIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKK
| ||..  ||  .. | .  . ...|..|| .   .  ||  ||| |||| ||..|..||| | ... || |||.||..||    ..     |. .||. 
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrry...iaaqgpnv

NTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSgaDETYGEIHVEAKSTEERDFGVLREFIIFkASEDKRKLTHFQFTKWPDKSVPKQTSLFLR
..|.||||....|.|  . |.|.| |  | |.| ||||   . .||.| |  || |  .    | . .    .. |..  ...| |||  ||| |  .. 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvv.fgdnirevvqlhytswpdmgvpkytiplmn

YMREVKKTYlADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQEL
..| ||.    .. ....||||||.||.| .|..|.|..||.    ..|. |.. .|. |..|||. ||| |...|.||..|| || |  | .  | . |
lirtvkqhh.tnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

TKQDPKGGQTLLDQEF
    |  | |||...|
lapspdtgstllqeqf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 155-399 4e-74 244.0 In-house 4-244 (250) alignment 
Range on Protein: 155-399
Range on HMM: 4-244/250.0
AKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTkCECYWPD
||  .|| |||| .|.....||||||  . |  |||||||....  ..|     |  .|| ..|. |||||...||. .. |.|.|.|  || .. ||| 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkaf...iatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SGAdETYGEIHVEAKSTEERDFGVLREFIIFKASED-KRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSV
 .| |.||...|. .|.||    . |.... ||..  .| . ...|. ||||.||...   | ....|...    ..||..|.||||.||||  ||.|.|
eka.ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVC
.|..|.  .|.|. .....|. | ..|.. |||||..|..|. |..
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN6_pd Subfamily PTPN6 126-394 1.4e-73 242.6 In-house 18-294 (306) alignment 
Range on Protein: 126-394
Range on HMM: 18-294/306.0
KyVHTNRQSLELIEEFEALPGVNTEQVT---YAKLEENKPKNRYRNILPYNNSRVVLEvIDDDPYSDYINASYIDVNPDHKFvLPTISHKGPKKNTVDDF
|  ... .   . ||||.|   .....     ..  ||| ||||.||||....||.|.  .. | ||||||.||. .   .     |. .|  ..|| ||
k.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdF

WRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIF--KASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMRE
|||.|||. ||. |.||  |  | ||  ||||. ..|.||.|.|.  | .. .  .|||. .   | ....|.. ...|..|||..|||... .| ....
WrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VKKTYLAD---DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTG---KVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVL
|.. .      .. |..||||||||| | .| .| .... ...|   ..... .|. .|| |. .|||..|| |...|. 
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
Y_phosphatase Protein-tyrosine phosphatase 160-395 1.4e-73 242.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 160-395
Range on HMM: 1-235/235.0
NKPKNRYRNILPYNNSRVVLeviDDDPY-SDYINASYIDVNPdHkfVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWP-DSGA
|| ||||..||||...|| |   ....  ||||||.|..  . .      |   || |.|..|||||.||||..|. |.|.|||  ..||. ||| ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.e..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

DETYGEIHVEAK-STE-ERDFGVLREFIIFKASEDK--RKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYlADDSAPLLVHCSAGIGRSGVLIAMDSV
 .|||.|.|| | ... . .  .||.. . |  |..  |.......|.|||..||.... .|...|.|.|.  ...|.|..||||||.||.|...|.| .
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

VEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.||......|.|  .|. .|..|..|||. |||.||..|.||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 160-395 1.4e-73 242.6 In-house 1-235 (235) alignment 
Range on Protein: 160-395
Range on HMM: 1-235/235.0
NKPKNRYRNILPYNNSRVVLeviDDDPY-SDYINASYIDVNPdHkfVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWP-DSGA
|| ||||..||||...|| |   ....  ||||||.|..  . .      |   || |.|..|||||.||||..|. |.|.|||  ..||. ||| ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.e..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

DETYGEIHVEAK-STE-ERDFGVLREFIIFKASEDK--RKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYlADDSAPLLVHCSAGIGRSGVLIAMDSV
 .|||.|.|| | ... . .  .||.. . |  |..  |.......|.|||..||.... .|...|.|.|.  ...|.|..||||||.||.|...|.| .
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

VEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.||......|.|  .|. .|..|..|||. |||.||..|.||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 152-396 2.3e-73 242.2 In-house 3-245 (249) alignment 
Range on Protein: 152-396
Range on HMM: 3-245/249.0
VTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECY
...|.|.|||.||||..||||..|||.|..... . ||||||||||.    .     |  .|| ..||.|||||.|...|.|. |.|.|.|  . ||. |
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr...fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDsGADETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLAD-DSAPLLVHCSAGIGRSGVLIA
||. |   .||...|. .|.|. |  ..|.. . .    ..|. .|.|.|.||| .||. .. .|.....|.| . .. .. |.|||||||.||.|..||
wpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

MDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
.. ..|| .....|..   |. .|..| ..||..|||.||.||.|| 
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN3_pd Subfamily PTPN3 135-395 2.1e-72 238.4 In-house 15-273 (280) alignment 
Range on Protein: 135-395
Range on HMM: 15-273/280.0
LELIEEFEALPGVNT-EQVTYAKLEENKPKNRYRNILPYNNSRVVLEvidDDPYsDYINASYIDVN-PDHKFVLPTISHKGPKKNTVDDFWRMIWQEKIR
 ... .|| |   .   ... |.. || .|||||.||||.. || |.   . .  |||||.|.... | ...|   |. .|| ..|. |||.|.|..|..
Gavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

VVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFKAS-EDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdSA
.. |.| | |  ..||  |||...   .|||..|. ....|.   ||||... ... ...||....|.. |||..||.... ||.....|.|.  .. . 
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk.ee

PLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
|..|||||||||.||||...  .    .. .|..   |. ||. |...||| .|| |. ||.|.
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0042113 (Phosphotyrosine protein) phosphatases II 153-395 2.8e-72 238.3 In-house 2-241 (245) alignment 
Range on Protein: 153-395
Range on HMM: 2-241/245.0
TYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYW
..|.|.|||.||||..||||...||.| ... |. ||||||||.|.    .     |   || ..||.|||||.|...|... |.|..||  . ||. ||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk...fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PDsGADETYGEIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMD
|. |   |||...|. .|.|  |  ..|.. . .  .  .|. .|.... ||| .||  ..|.|. ...|.| . .|.. |.|||||||.||.|..||..
pl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

SVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
 ..||......|..   |. .|..| ..|||..||.||.||.||
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 125-417 3.1e-72 238.3 In-house 11-306 (307) alignment 
Range on Protein: 125-417
Range on HMM: 11-306/307.0
TKYVHTNRQS-LELIEEFEALPGVNTEQ-VTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHK-FvlptISHKGPKKNTVDD
....  .|..   |..|.| |.  ....  . .. .||. |||| .| .... ||.|..|  . .|||||||.|    ..| |    |  ..|  .|..|
ealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkf....iaaqdPveatigD

FWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSgADETYGEIHVEAKSTEERDFGVLREFIIFKAS------EDKRKLTHFQFTKWPDKSVPKQTSLFL
|||||.. .. .. |...|.|  . ||. |||.      ||.| |.  |.|. .  . ||. . |        ||.||.. ...| |.|  ||...   |
fWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

RYMREVKKTYLADdSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQE
.....|.. |  .  .|..|||||| ||||...|.||...| |   ||..  .|. .|. |. .||  ||||||. |.|.     || . || .| ....
klieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaier

LT
| 
lc
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 131-397 4.8e-72 237.4 In-house 11-276 (281) alignment 
Range on Protein: 131-397
Range on HMM: 11-276/281.0
NRQSLELIEEFEALPGVNTEQVTYAK-LEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYID-VNPDHKFvlptISHKGPKKNTVDDFWRMIWQ
. ..  .|||.|.|  ....... |   .||. ||||.||  |...||...  ...  .|||||.... .. ....    |  .||  .....||.|.|.
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekey....iatqgPvPaslvafWqmvwe

EKIRVVSMVTKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLAD
.|.... |||.  |  | ||  ||||  .. .||...|. ...||.   . |.| . . | ..|.......|.|||. ||..|. .| . .||.|.   .
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRT-GKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
  |||..|||||.||.|. ||.| .|......  ...|.  |. .|. |. ||||  || |.. |||. |
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045098 (Phosphotyrosine protein) phosphatases II 138-399 9.8e-72 236.9 In-house 11-274 (278) alignment 
Range on Protein: 138-399
Range on HMM: 11-274/278.0
IEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVlevidddpysDYINASYIDVNpDHKFvlptISHKGPKKNTVDDFWRMIWQEKIRVVSMV
.| .. |.  .  ..|.| ...|..||||..||||..|||.          |||||||||.  ..||    |   ||...||.|||||.|...|.|. |.
lefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.pkkf....IatqgPlpstvadfwrmlwelgitvivml

TKLEEVLKTKCECYWPDsGADETYGEIHVEAKSTEERDFGVLREFIIFK-----ASEDKRKLTHFQFTKWPDKSVPKQT--SLFLRYMREVKKTYL----
|.|.|  . ||. |||. |  .|||...|. .|.|. |  .|| ...       ..  .|..||.... ||| .|| ..  . ||........ .     
telvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

--------ADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAkrTGKVNVHGFVQAMRECRQN-MVQTDEQYVFLHEAVLESLVC
         |.. | |||||||.||.|.|.|.. . |.    |.|..   |. .|..| . .||. |||.||.|..|| | .
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRG_pd Subfamily PTPRG 121-405 2.8e-70 232.1 In-house 3-295 (563) alignment 
Range on Protein: 121-405
Range on HMM: 3-295/563.0
LDEFTKYVHTNR--QSLELIEEFEALPGVNTEQ---VTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYS-DYINASYIDV-NPDHKFvlptISHKG
..||.|.|      .   . ||||||    ...   .. .. .||| |||| ||..|..||| |. . .   . |||||.|||  .  ..|    |  .|
vkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskaf....iatqg

PKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDsGADETYGEIHVEAKSTEERDFGVLREFIIFK----ASE---DKRKLTHFQFTKWPDKS
| |.|.||||||||...  .. |.|.|.|  . ||. |||     ||||...|  ...|       |...| .    . .   .... .....|||||..
plkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPKQTSLFLRYMREVKKTyLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIP
||...   | ...  ...   ..  |..||||||.||.|..|..|....| ..  .|||.||.. .|  |...||| |||.|||.|.|| .   .| . 
vPehslpvLifvkkssaa.nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_PTPN12_pd Subfamily PTPN12 153-396 3.3e-69 227.9 In-house 33-276 (290) alignment 
Range on Protein: 153-396
Range on HMM: 33-276/290.0
TYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYW
. .. |||. ||||..||||..|||.|. |.... ||||||..|    ...     |. .||  .|.||||||||. ....| |. .. |. |.|||.||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkley...iaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PDSGADET-YGEIHVEAKSTEERDFGVLREFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKtYLADDSAPLLVHCSAGIGRSGVLIAMD
|..| .|. .||..|. .. .  | . |   .  .|....||.. |..|.|||. ||....  |. ...|.. .  ...|||.||||||.|| |..||.|
peegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvre.lqesedaPlvvhCsaGvGrtGtiiaid

SVVEQAKRT---GKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
 | |. |.     ...|.  |. .|. |. .||| |||.....||.| 
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN13_pd Subfamily PTPN13 138-397 2.4e-68 225.4 In-house 14-269 (273) alignment 
Range on Protein: 138-397
Range on HMM: 14-269/273.0
IEEFEALPGVN-TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEviDDDPysdYINASYIDVNPDHKfVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSM
 |||. |  .  ..... .| .||| ||||||.|||...|| |.  |. .   |||||.| |. ...     |  .||  .||.|||.|.|. | .|. |
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg..degg...yinaslikvpvgkd.eyeyiacqGPlPetvkdfwqmvweqkaeviam

VTKLEEVLKTKCECYWPDSGADET--YGEIHVEAKSTEERD-FGVLREFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKtyLADDSAPL
||.  |  | ||. |||.|  ...  .. ..||   ....| | | .  .. ..|.. |...|..|.|||| .||...  .|....||..  |..|..|.
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr..lqtdagPi

LVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
.|||||||||||.||..| |..  .|  ...|.  |. .|| || .|||..||.| ..|.|| |
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 136-433 3.3e-68 225.2 In-house 24-324 (325) alignment 
Range on Protein: 136-433
Range on HMM: 24-324/325.0
ELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVLPTishKGPKKNTVDDFWRMI--WQekIRV
 .  ||. || ...   . | . ||| |||..|......||||||  .||| ||||||||.  . . .  | .   . |. .|..|.||..  |.    |
gfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaa...qaPltatindlWrlvldWr..csv

VSMVTKLEEvLKTKCECYWPDS-GADETYGEIHVEAKSTEERDFGVLREFIIFKASED-KRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKT---YLA-
| .. .|..  | .|  |||.  |   |.| ..|. .. ||    | | . . ....   | .  ||.  |.|  |.|. . .. ... ||.      | 
vvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

-DDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTKQDPKGGQT
   |.|.|||||||.||.||.|.. |....     .|.. |||. .|. | .||.| .||....||. | ... .| .||  || .|  | ...|   . 
tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqkl

LLDQEFK
 ...||.
niekefe
subfamily_PTPN9_pd Subfamily PTPN9 121-395 6.2e-68 224.0 In-house 3-288 (297) alignment 
Range on Protein: 121-395
Range on HMM: 3-288/297.0
LDEFTKYVHTNRQSlELIEEFEALPGVNTE-QVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTV
..|. .||. ....  |..|....   ..| .....||  |  |||| ..| |...||||. .|.|..||||||...|    .| .   |. .|| |.||
ieelvayvkekgkr.GlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkaf...iatqGplkktv

DDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWP-DSGADETYGEIHVEAKSTEERDFGVLREFIIF-KASEDKRKLTHFQFTKWPDKSVPKQTSLFLRY
.|||||.|.....|. |.|...|  . ||  ||| .... . .|...|.  ..||..  . | . |     |..||.|||||. |||  ||.... .|  
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

MREVKK------TYLADD------SAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
...|..      ..|.|.        |..|||||||||.| .|..|  ... ...|.|.|   |. .|. |  ..||.|||.| . ||||
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0037934 (Phosphotyrosine protein) phosphatases II 153-395 1.5e-67 223.0 In-house 3-240 (243) alignment 
Range on Protein: 153-395
Range on HMM: 3-240/243.0
TYAKLEENKPKNRYRNILPYNNSRVVLevidDDpySDYINASYIDVNPdhkfvlPTISHKGPKKNTVDD----FWRMIWQEKIRVVSMVTKLEEVLKTKC
..|.|.||..||||..||||..|||.|    ..  ||||||..|.| |        |   || ..||.|    ||||.|...|.|. |.|.|.|  . ||
siallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

ECYWPDSGadeTYGEIHVEAKSTEERDFGVLREFIIFK--ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLA-------DDSAPLLVHCSA
. |||..    |||...|. .|.|. |  ..|.. .    ... .|  .|.... ||| .||  .. .|....||.. . .       |.. |.||||||
aqywpgev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GIGRSGVLIAMDSVVEQAkrtgKVNVHGFVQAMRECRQN-MVQTDEQYVFLHEAVLE
|.||.|.|||.. . ..     .|..   |. .||.| . .||| .||.||.||.||
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 134-395 3e-67 221.6 In-house 4-266 (274) alignment 
Range on Protein: 134-395
Range on HMM: 4-266/274.0
SLELIEEFEALPgVNTeQVTYAKLEENKPKNRYRNILPYNNSRVVLEV-IDDDPYSDYINASYIDVNPDHKFVlpTISHKGPKKNTVDDFWRMIWQEKIR
. .| .||  || .|  .    ..  .. ||||..||| .||||.||    .|. |.|||| ||     .. .   .. .||  |||.||||||.||...
fkdlekeflelP.lnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeska..yvatqGPlpntvadfWrmiyqeevq

VVSMVTKLEEVLKTKCECYWPDSGA---DETYGEIHVEAKSTEERDFGVLREFIIFKASEdKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADD
|. |.|||.|  ..||. |.||.     .|.||..... ... ||.   .|.... .... .|...|. .|.|||. .|.... .|. ..||...  ...
vivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeen

S--APLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
   || .||||||||| |. ||..  | | .....|.| . |  .|  |  ||||.||| ..|.|. .
aklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 153-395 2e-65 215.5 In-house 13-262 (270) alignment 
Range on Protein: 153-395
Range on HMM: 13-262/270.0
TYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVN-PDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECY
.  .   .|  |||..|||  ..||.|| ...|. . |||| |.     ..|     |. .||...|. .||||||.|| . . |.|.|||  ..|||.|
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk...YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDSGAD---ETYGEIHVEAKSTEERDFGVLREFIIFkASEDKRKLTHFQFTKWPDKSVPKQTS------LFLRYMREVKKTYLADDSA-PLLVHCSAGI
|| .  .    ..|.|.| | |.| ... .|..  .   . ..|.|.||....|||..||...         |. .|.|...    | | |||||||||.
Wpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
||.|.|||.| .|.  ..|.||.|   ....|. | ..||. ||| ||..||.|
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 133-418 1.1e-63 210.5 In-house 32-312 (319) alignment 
Range on Protein: 133-418
Range on HMM: 32-312/319.0
QSLELIEEFEALP--GVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDH-KFvlptISHKGPKKNTVDDFWRMIWQE
.  .|  || ...  |||  . |.| |..|| |||. |||......| || ..   .|||||||...    . |.    |. .||..||..|||||||. 
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdky....iaaqGPldntladfWrmiwey

KIRVVSMVTkleevlKTKCECYWPDSGaDETYGEIHVEAKSTEERDFGVLREFIIFK--ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKK-TYL
..  . ..|      | ||  |||  . ...... .|. .| || .  |.|.. . .    .|.||.| | |  |||. ||...| ..| .. |.. |  
ncstivllt......kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

ADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTK
 .. |...||||||.||.|| |..| .... |.  .|.|. ||. .|. |...||   || |.. |.||  .   . . .  | . |.||..
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 146-418 1.3e-62 206.9 In-house 11-276 (284) alignment 
Range on Protein: 146-418
Range on HMM: 11-276/284.0
GVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHK-FvlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTkleevl
|||. . |.| |..|| |||. .||......| || ..   .|||||||.|     .. .    |. .||..||..|||||||. ..  . ..|      
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdky....iatqGPldntladfWrmiweyncstivllt......

KTKCECYWPDSGaDETYGEIHVEAKSTEERDFGVLREFIIFK--ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKK-TYLADDSAPLLVHCSAGI
| ||  |||  . ...... .|. .| || .  |.|.. . .    .|.||.. | |  |||. ||...| ..| .. |.. |   .. |...||||||.
kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

GRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFEVRLQELTK
||.|| |..| .... |.  .|.|. ||. .|. |...||   || |.. |.||  .   . . .  | . |.||..
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 122-410 3.8e-61 201.9 In-house 5-292 (439) alignment 
Range on Protein: 122-410
Range on HMM: 5-292/439.0
DEFTKYV---HTNRQSLeLIEEFEALPGVNTE---QVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGPK
||| ..|   . |.| . . |.|| .  .. .   . . |  | ...||||... ... .||.|. |   |.| |||| ||.   | |.    |. .|||
defqehvekldknkqei.fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkly...iatqgpk

KNTVDDFWRMIWQEKIRVVSMVTKLEEVLKtkcecYWPDSgADETYGEIHVEAKSTEERDFGVLREFIIFKA---SEDKRKLTHFQFTKWPDKSVPKQTS
|.|.|||||.....|   . |.|.| |  |     ||| . |.  ||.| | .    |    |.| | .|.    .| .| . .|... |||| || |.|
kettddfwrlviekktvtivmltnlvesyk.....ywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas

LFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIPVDGFE
  | ..| .. .   ..  |..||||||.||.| .||.|  .|| |   ||...| |. .|. |..|||.  ||||...|||| .|  |. . .| |.
hvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 120-397 4.9e-61 201.1 In-house 3-283 (290) alignment 
Range on Protein: 120-397
Range on HMM: 3-283/290.0
SLDEFTKYVHTNRQSL--ELIEEFEALP-GVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDD--DPYSDYINASYID-VNPDHKFvlptISHKG
 .|.|...| ....       ..|..|  | . ..||..  ..||..||..||..|.. |..|  | .  |   .||||.||.  . ....    |  .|
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy....iatqg

PKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGADEtYGEIHVEAKSTEERDFGVLREFIIFKASE--DKRKLTHFQFTKWPDKSVPKQT
| .||. |||..|||||. .. |.|.  |  |.||  |||||.... |||....  . |. .  . |.. . . ..  .|...|..|.| |...   ...
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp

SLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
.  |  ..|. ||   .   ...||||...|||.|..|..  ....| .| ..|   .. .| .. ..||| .|| .... ||..|
qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 155-395 2.4e-60 198.7 In-house 2-238 (239) alignment 
Range on Protein: 155-395
Range on HMM: 2-238/239.0
AKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYID-VNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWP
||   || |||| ||. |. |||||| . .||.||||||||.   .   |     |. .|  . .  |||||.|||.  |. |.| | |  | ||  |||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspka...yiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

DSGAdeTYGEIHVEAKSTEERDFGVLREFIIFKASE-DKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdSAPLLVHCSAGIGRSGVLIAMDS
|| .   | ...|  . ||     ..| |.. .  . ..| . ...|| |||| ||. ..  |   |.. |  |   . | ..|||||.||.| .. .|.
dsts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtgaflvida

VVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.. |||.   |..  .|.|.|| |  |||| |||||.| ||||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 155-395 4e-60 197.9 In-house 3-239 (239) alignment 
Range on Protein: 155-395
Range on HMM: 3-239/239.0
AKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYID-VNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWP
||   || |||| ||. |. |||||| . .||.||||||||.   .   |     |. .|  . .  |||||.|||.  |. |.| | |  | ||  |||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspka...yiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

DSGAdeTYGEIHVEAKSTEERDFGVLREFIIFKASE-DKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdSAPLLVHCSAGIGRSGVLIAMDS
|| .   | ...|  . ||     ..| |.. .  . ..| . ...|| |||| ||. ..  |   |.. |  |   . | ..|||||.||.| .. .|.
dsts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtgaflvida

VVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
.. |||.   |..  .|.|.|| |  |||| |||||.| ||||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 139-404 1.1e-59 196.7 In-house 13-273 (283) alignment 
Range on Protein: 139-404
Range on HMM: 13-273/283.0
EEFEALpGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDdpysDYINASYIDVNPDHKFVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVT
| .. | .|   ... |  .|||.|||...|.|... || |.        |||||..| |. ..|     |  ..| ..|| |||.|...|||  . |.|
evlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

KLEEVLKTKCECYWPDSGADEtYGEIHVEAKSTEERDFGVLREFIIFKASEDK--RKLTHFQFTKWpdKSVPKQTSL-FLRYMREVKKTYLADDSAPLLV
|| | |. ||  |||  |. . |||  |  .     .  . .|... . |  |    |.|.|.  |   .. .|. .  |  .  |.        .|..|
klqedlrikCsqyWPkrGsed.yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkfnkvislqteskkgPivv

HCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRI
|||.||||..|.||. . |..|.    |.|   |. ||| |  .||| .|| ..||.|||  .| ||.|
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
subfamily_PTPN14_pd Subfamily PTPN14 117-397 1.8e-59 196.2 In-house 5-296 (300) alignment 
Range on Protein: 117-397
Range on HMM: 5-296/300.0
TGISLDEFTKYVHTNRQSLELIEEFEALPGVNTEQVT-YAKLEENKPKNRYRNILPYNNSRVVLEVIDDDpYSDYINASYIDVNPDHKFvLPTISHKGPK
|  . |. .| .. . .. ..  |.| .|  ... ..  |||.||..|||....|||...|| |    ..  ..||||| | |    |  .  |  .|| 
tratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggke.rsyivaqgPl

KNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA---DETYGEIHVEAKSTEERDFGVLREFII-FKASEDKRKLTHFQFTKWPDKSVPKQT
..|| |||.|.|....... |.|. ||  |.|.  |.|...      ..|. .| .| .|. |  . . . . .  |...|.. |.|.| |||. ||.  
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDv

SLFLRYMREVKKTYLAD--------DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
. || |..||.    .          . |.|||||||.||.||||  | ...  .   .....  .. .|| |. .|||  || |........|
kgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 159-395 2.6e-58 192.1 In-house 2-237 (237) alignment 
Range on Protein: 159-395
Range on HMM: 2-237/237.0
ENKPKNRYRNILPYNNSRVVLEVIDDDpySDYINASYIDVNPDHkfVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAD
||| |||| ||  |. |||||.    .  ||||||.|..           |. .|| ... ||||.|.||||  |. |.| | |  . ||  |||..   
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgt..pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

ETYGEIHVEAKSTEERDFGVLREFIIFKASEDK--RKLTHFQFTKWPDKSVPKQTSLFLRYMREV-KKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVE
..|| . |  |  ||     .| ....|  . |  | .  .||| |||. ||.||. .||. ... ...    .|.| ..|||||.||.|... .|... 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
|||    |... .|... | |  ..|| .||||.|...||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 122-403 3.3e-58 191.9 In-house 5-284 (287) alignment 
Range on Protein: 122-403
Range on HMM: 5-284/287.0
DEFTKYVHTN--RQSLELIEEFEALPGV--NTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEviddDPYSDYINASYIDVNPDHKFVlptISHKGPKKN
..| ..|...  . . .  . |  |  |  . ..|| .  ..||.|||...||...| ||.|.    .   |||||..||   ..|     |  ..|  |
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkaf...iiaesPmfn

TVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAdETYGEIHVEAKSTEERDFGVLREFIIFKAS--EDKRKLTHFQFTKWPDKS-VPKQTSLF
|. .||..|..... .. |.....|  . .|  |||.. .  ..|| ..|  . |  .  . |.. . . .  .||.... .|.|.|...  |... . .
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LrYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTR
|  . |  ||      ....||||...|||....|..  ....|. | ..|   .. .|  . ..||| ||| |. ..|||.| . .|.
l.vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_PTPN23_pd Subfamily PTPN23 149-396 2.1e-56 185.9 In-house 32-279 (288) alignment 
Range on Protein: 149-396
Range on HMM: 32-279/288.0
TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEviddDPYSDYINASYID-VNPDhkfVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTK
... . |  . .  |||.|.||||...||.|.    .   ||||||..  . |      . |  ..|...|. |||.|....| .|. |... ||  |.|
arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspg...cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpk

CECYWP-DSGADETYGEIHVEAKSTEERDFGVLREFII-FKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLAD---DSAPLLVHCSAGIG
.. ||| | |. ...|...|  ||..| .  | |.... .. .. .....| |.|.||.  ||.  . .|... ||...| |      .||.||||||.|
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RSGVLIAMDSVVE-QAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
|.||.  . ..|.   |. | ...   |. .|| |..|||. ||. |. ||||| 
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN1_pd Subfamily PTPN1 151-400 2.2e-55 182.4 In-house 23-276 (290) alignment 
Range on Protein: 151-400
Range on HMM: 23-276/290.0
QVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDdpysDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCEC
... |||.||...||||.. ||. ||..||  |     |||||| ....  ..     |  .||  |||| ||.|.|..| . | |. |. |  ..||  
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsy...iltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPDSGA-DETYG---EIHVEAKSTEERDFGVLREFIIFK-ASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKT-YLADDSAPLLVHCSAGIGRS
|||     .|      ...|.  |.|.... ..| . . .  ... |...|| .|.||| .||.  . ||... .|...  |..|  | ..|||||||||
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GVLIAMDSVVEQAKRTGK---VNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL--VCD
| .. .|... . .....   |...  . ..|. |  ..|| .|  | . |.||    . .
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
subfamily_CG7180_pd Subfamily CG7180 124-401 7.9e-54 177.3 In-house 5-294 (296) alignment 
Range on Protein: 124-401
Range on HMM: 5-294/296.0
FTKYVHTN-RQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNP-DHKFVLpTishKGPKKNTVDD
| |.|.   .  .|   |..  | .....   .  .||. |||. ...||.. ||||| .| .  ||||||.|.|    .....  |   ..|||.|||.
flklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyiv.t...eapkketvde

FWRMIWQEKIRVVSMVTKLEEVLKtKCECYWPDSGaDETYGEIHVEAKSTEERDFGVLREFIIFKA-----------SEDKRKLTHFQFTKWPD-KSVPK
|||....|.|  | ..||  .  | ..  |||  .  | |||| ||  ....    . |.| . |            . ..| ...||.|.|.  ..|| 
fWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPl

QTSLFLRYMREVKKTYL----ADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDD
 |. ..  .| |..        .. .|..|..| | .|||| .|.|  .|.......|.| ..|. .|. |...|.. |.| .. . .|| ..|  
stnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRN_pd Subfamily PTPRN 136-396 4e-51 168.5 In-house 30-291 (297) alignment 
Range on Protein: 136-396
Range on HMM: 30-291/297.0
ELIEEFEALPGVNTEQVTY--AKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYI-DVNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIR
 | .|.|||   ..|. |   || |.|  |||....|||..||| |.   ..  ||||||| | | .| .      |. .||  .|| |||.|.|.. . 
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa...yiatqgplastvadfwqmvweqGvv

VVSMVTKLEEVLKTKCECYWPDSGADeTYG--EIHVEAKSTEERDFGVLREFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLAdDS
|. ..|.|||   ..|. |||| |.. .|.  |.|. ..     |. |   ..    ... | .| | |  ||...|| ..  .| . | | |.|    |
vivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rs

APLLVHCSAGIGRSGVLIAMDSVVEQAKRT-GKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
.|..||||.| ||.|| |..| |... ..   ....   .. .|. |...|.| .|. |   || | 
cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 129-403 1.1e-50 167.1 In-house 9-299 (301) alignment 
Range on Protein: 129-403
Range on HMM: 9-299/301.0
HTNRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDD--DPYSDYINASYIDVNPD-HKFvlptISHKGPKKNTVDDFWRM
... .| .. |....|  .. .. |    ||||. ||..|| .|.. |..|.   .      .||||||||   . .||    |  .|| |.|. ||||.
vaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkf....iaaqgpmkktlvdfWrl

IWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA-DETYGEIHVEAKSTE-ERDFgVLREFI--I------------F--KASEDKRKLTHFQFTKWPDKSV
|||||   . |||.|.|  |.||| |||.| | .|..|...|. ...    || |.|..   |            |  |.. . .... .| |.||.  |
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdf.virqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

PKQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTR
 ..    |. . .| ..    . .|..||||....|||| ....  .||.|. | |.| . ..|.|  .  .|.| |||....... . | ...| 
vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 133-395 8e-46 151.0 In-house 29-281 (290) alignment 
Range on Protein: 133-395
Range on HMM: 29-281/290.0
QSLELIEEFEAL-PGVNTEQVTYAKLEENKpKNRYRNILPYNNSRVVLEvidDDPYSDYINASYIDVNpDHKFVLptisHKGPKKNTVDDFWRMIWQEKI
 . | .|.     |.   |.  . |  | | ||||...   . .||.|.   |    ||. | |..   .  |.|     .|. |.|| |.|||. |||.
lakeyleklkpylpvqylerkifdkntefk.knrykdvvcndktrvilk...dGydGdyvhanyvkGl.kamfil....tqGalkdtvidiwrmvlqekv

RVVSMVTKLEEVLKTKCECYWPDS-GADETYGEIHVEAKSTEERDFGVLREFIIF--KASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTylad
 .. |. .| |  |.||| |.|.  |   |.||| |     ...|  . .  .    | |  . || |..   ||||||.. |  .|| .| ..|.    
aaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....

dSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
 | |. |||||||||.| ..|..  ..      .... . |.|.|..| | || | ||. | |..|.
.sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0041856 (Phosphotyrosine protein) phosphatases II 160-405 2.1e-45 149.9 In-house 1-179 (182) alignment 
Range on Protein: 160-405
Range on HMM: 1-179/182.0
NKPKNRYRNILPYNNSRvvlevidddpYSDYINASYIDVNPDHKFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTkleevlktkCECYWPdsgade
|..||||..||||..||          ..|||||.... .  ..     |  .|| ..|| ||.||.....|... ..|         .|.|||      
nldknrysdilpydhsr..........dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

tygeihveaksteerdfgvlrefiifkaSEDKRKLTHFQFTKWPDKSVPKqTSLFLRYMREVKKtyladDSAPLLVHCSAGIGRSGVLIAMDSVVEQakr
                            .. .|  ...... ||| .||  .. .|....||..     .. | |||||||.||.|.|.|.. . ..   
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl...

tgKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVCDDTRIP
  .|..   |. .|..| .||.| .||.||. |.|| | ...||..
..gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 159-394 2e-44 146.5 In-house 37-274 (287) alignment 
Range on Protein: 159-394
Range on HMM: 37-274/287.0
ENKPKNRYRNILPYNNSRVVLeVIDDDPYSDYINASYIDVNPDHK-FvlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA
 .  |||| ..||....||.| . . .  |||||| |.    |.. |    |. .||   || ||||......  .| ..|.  |  . ||  |||.   
aavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeaf....iaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev

DETYGEIHVEAKS--TEERDFGVlREFIIFKASEDK-RKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKT----YLADDSAPLLVHCSAGIGRSGVLIAM
    |   | . .    | ..|| | . . ..   . | .  ... .||||...  .  ..|.. .||.       |..  ||.||...||||||.|.|.
PmrvGGysvvlldydikePeygv.ralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVL
  .|.. . .|.|.|   |  .|| |. .||.  |. .| ||. 
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0051429 (Phosphotyrosine protein) phosphatases II 186-399 3.6e-44 146.8 In-house 2-226 (272) alignment 
Range on Protein: 186-399
Range on HMM: 2-226/272.0
PYSDYINASYIDVNpdhkfvL----PT--ISHKGPKKNTVDDFWRMiWQEKIRVVSMVTKLEEVLKTKCECYWP-----------DSGADETYGEIHVEA
|.|.||||.... .           |   .   || ..|..||||. ....|... .....||. . ||..|||           ||  . .|| ..|  
plsgyiNardvggy......grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtl

KSTEERDFGVLREFIIFKA--SEDKRKLTHFQFTKWPDKSVPKQTslFLRYMREVKKtyladdSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVN--
 |.|  .. .|||... .    .. |...|...| ||| .||...  .|. .... .      . |.|||||||..|.|...|.. ....  ..  |.  
lseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddY

------VHGFVQAMRECRQNMVQTDEQYVFLHEAVLESlVC
      . ..|. .|..| ..|||.|||.||.||.||  ..
lltnlyleeaveelraqrpgavqteeqylflyeallel.lr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 135-396 2.3e-41 136.8 In-house 16-276 (307) alignment 
Range on Protein: 135-396
Range on HMM: 16-276/307.0
LELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVidDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIRVV
 .|..||. |   . | ||   .. |  ||||...   ...|.|...  |   |||| | |. .  . |     |  .||..||. .|| |. |||.  |
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkf...icaqgplentqysfwamaiqekvesv

SMVTKLEEVLKTKCECYWPD-SGADETYGEIH----VE---AKST-EERDFGVLREfIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKty
 |. |. |. | ||| |||   |   ..||      |.   ||    . |.  . . .  . ... | ..|.|...|||. ||.     .  .  |.   
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvtt.lkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..

ladDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRT-GKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
   |  |..||||||.|||| ..|.  | ..  .     ... .|. .|. |.  .||. ||..||  .|| 
...dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0051299 (Phosphotyrosine protein) phosphatases II 401-580 1.2e-39 132.0 In-house 2-172 (288) alignment 
Range on Protein: 401-580
Range on HMM: 2-172/288.0
DTRIPVDGFEVRLQELTkqdpKGGQTLLDQEFKTLSKISPDpspLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSnEPFGDYINASFVksMGNDSS
||.|.|. .. ....|.    ..|.|.| .||..| .. ||   | ...... | ..||| |..|| ...| .|... . ....||||||..   | ...
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyi..dgynlk

PYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLT
  .|.|| |||.|| .|| .|.... ..||||..|.  .  .  ||||.|||..||..|. ..|.|.. ...||||.|. .
rkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 135-395 1.6e-39 130.5 In-house 6-257 (267) alignment 
Range on Protein: 135-395
Range on HMM: 6-257/267.0
LELIEEFEALPGVNTEQVT--YAKLEENKPKNRYRNILPYNNSRVVLEVIDDDpysdYINASYIDVNPDHKFVLPTIshkGPKKNTVDDFWRMIWQEKIR
 |. .||| .  . ... |      |.|. .||. . |||...||.|   ...    ||||||..     .  . |    .| |||. ||. .| ..|. 
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtq...dplkntitdfltvihdqkvp

VVSMVTKleeVLKTKCECYWPDS-GADETYGEIHVEAK-STEERDFGVLREFIIFKAsEDKRKLTHFQFTKWPDKSVPKQtsLFLRYMREVKKTYLADDS
|. ..||   | . .   .||   |  . | .. ||     || |. ..   . ||  |  ...| . . ||  ..  |    .   .  . |  | . .
vivlltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintnnkp..ylkplfgilaknqlengn

APLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
 ||.|.||.|.|||| .. .|| .|.||. | .... |.. .|. |  .|.| |.|...|| . |
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0043147 (Phosphotyrosine protein) phosphatases II 185-391 4e-39 129.5 In-house 2-155 (172) alignment 
Range on Protein: 185-391
Range on HMM: 2-155/172.0
DPYSDYINASYIDVNPdhkFVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLeevlktkcecywpdsgadetygeihveaksteerdfgvlrefiI
|..||||||||.|..         | . ||  ||..|||||.....|... ..|.|                                            
degsdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel...........................................l

FKASEDKRKLTHFQFTKWPDKSVPkQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVeqakrtGKVNVHGFVQAMRECRQNMVQTDE
  ..  .|   ..... ||| .||  ..|.|. .. ... .. ... | |||||||.||.|.|.|.. .        .....  |. .||.| ..||...
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVFLHE
|| ||..
qyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 188-391 6e-38 125.6 In-house 2-164 (174) alignment 
Range on Protein: 188-391
Range on HMM: 2-164/174.0
SDYINASYIDVNPDHKfvlPTISHKGPKKntvddFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDsgadetygeihveaksteerdfgvlrefiifKA
|||||||..|..   .     |  .|| .     ||.|.....|..| |.....|  ..||  |||.                               . 
sdyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lr

SEDKRKLTHFQFTKWPDKSVPKQTSlFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKrTGKVNVHGFVQAMRECRQNMVQTDEQYV
.  .|   ..... ||| .||  .  .|. ...|.. .. |.. |.|||||||.||.|.|.|.. .  . . .. |..  .|...| .| .||||..|| 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FLHE
||..
flyy
0050432 (Phosphotyrosine protein) phosphatases II 401-581 7.7e-38 126.0 In-house 16-192 (308) alignment 
Range on Protein: 401-581
Range on HMM: 16-192/308.0
DTRIPVDGFEVRLQELTK-QDPKGGQTLLDQEFKTLSKISPdpsPLAIRTGSKAECKKKNRDSSVLPIERNRAILqswysnEPFGDYINASFVKSMGNDS
|| |.|  .......| |  ... . .||..||..| .. |   .| ...... | |.||| ...|| ...| .|      ..  ||||||.|.   ...
dtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgysskl

SPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPDG---GSVQYGPFTISTTSVEKNIGMIVRTLQVQLTE
.  .|.|| |||.|| .|| .|.... ..||||..|.  .  .  ||||.    ||..||.||. ..|.|.. ...||||... ..
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 402-580 1e-37 125.0 In-house 3-179 (298) alignment 
Range on Protein: 402-580
Range on HMM: 3-179/298.0
TRIPVDGFEVRLQELTKQDPKGGQTLLDQEFKTLSKISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKsmGNDSSP
| | .. ..  ||.|.. ..| . | ...||..|...| .      . ..| | ||||| .......  | .|..  ..|  .|||||||..  . . ..
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedade.esdYiNAsflh..aykgrn

YYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-TTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLT
 .|.|| ||.|||..|| .| ... .|||||..|  .|  .  .|||| |. .|| .|.|  | |.   .|||.|.|. .
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskk
0046846 (Phosphotyrosine protein) phosphatases II 180-395 3.5e-37 123.2 In-house 4-171 (176) alignment 
Range on Protein: 180-395
Range on HMM: 4-171/176.0
EVIDDDPYSDYINASYIDVNpdhkFvlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDsgaDE---Tygeihveaksteerdf
 .. .|...|||||..|. .    .    | . ||  .|. ||..|.....|..| ..|.. |  . ||  |||.    |                    
rllgldldldyinanlilgs....r...piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi................

gvlrefiifkasedkrkltHFQFTKWPDKSVPKQtSLFLRYMREVKKTYLADdsAPLLVHCSAGIGRSGVLIAMDsvveQAKRTGKVNVHGFVQAMRECR
                   ..... ||| .||   .|.|. ...... . ..   | ||||||||||.|.|.|..      ..   ..|.  .. .||.|
...................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqR

Q-NMVQTDEQYVFLHEAVLE
  ..|||.||| ||.|..|.
plgavqtpeQyrflyefell
0049772 (Phosphotyrosine protein) phosphatases II 152-396 5.9e-37 123.4 In-house 38-279 (314) alignment 
Range on Protein: 152-396
Range on HMM: 38-279/314.0
VTYAKLEENKPKNRYRNILPYNnSRVVLEVIDDDPySDYINASYIDVNpdhkfvLPTISHKGPKKNTVDDF----------WRMI--WQEKIRVVSM---
.. |.|..|. |||| .|||.. .||.|   . .  ||||||||.|        |  |  .||...||.||          |||.  .. ..|.. |   
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------VTKLEEVLktkcecywpdsgadetygeihveaKSTEERDFGVLReFIIFKASEDKRKLTHFQFTKWPDKSVPkQTSLFLRYM
                   ..| .                              ..|.  |.  ... ..  .|   ..  . .|| |.|  .. |.. .
evladelsrLdaAlgKtpllildgng........................neptaadlellk.eelydpelferlgikylripvpDgsap.lledfdefl

REVKKTylaDDSAPLLVHCSAGIGRSGVLIAMDSVVEQAkrtgKVNVHGFVQAMRECRQ-----NMVQTDEQYVFLHEAVLES
. ...    |.  |.||||.||.||.|...... .. .     .|...  .. .|..|      ..... |||.| .||.|| 
efieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 149-321 8.9e-37 121.5 In-house 22-193 (297) alignment 
Range on Protein: 149-321
Range on HMM: 22-193/297.0
TEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIddDPYSDYINASYIdVNPDHKFVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKC
.|. . || .    |||||.|| ....|| |      . .||||| |. | || .  |  |  .|| ..||||||...... .||. ||.||.|  . ||
gesfssakrnsslrknryrdilatddtrvkllrv..iterdyinadyv.vfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

ECYWPDSGA-DETYGEIHVEAKSTEERDFG--VLREFIIFKAsEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREV
  |||..     . |.. ||  |.   .|   .| |. ..   ...|...| ||  |||. || .     |.  .|
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_ptpA1_pd Subfamily ptpA1 121-349 1.8e-36 120.8 In-house 13-248 (418) alignment 
Range on Protein: 121-349
Range on HMM: 13-248/418.0
LDEFTKYVHTNRQSLELIEEfealpGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFvlptISHKGPKKNTVD
| .. | .|  .. . |.||      |   . .    . |  |||| |||| | .|| |. |.|   |||||| |||    ..|    |  .||  ||. 
lknhikcihkikeefrllee.....svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqf....ictqgplpntia

DFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA----------DETYGEIHVEAK-STEERDFGVLREFIIFKASEDKRKLTHFQFTKWPDKSVPK
|||||.|... |.. |...  |  . ||. |||.             .| .|   ||     .. .  ..   | .    . | .|..|.  |||. .| 
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipd

QTSLFLRYMREVKK-----TYLADDSAPLLVHCSAGIGRSGVLIA
.|  | . .. . .        .|   |..||||||.||.| . .
htqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 290-437 2.8e-36 119.8 In-house 87-234 (440) alignment 
Range on Protein: 290-437
Range on HMM: 87-234/440.0
DKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFL
. | | ....  ||||.||| ..  |. ...|...     ..||||||||| ||.||.||.||.. .|||. ....  |...||. | .|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HEAVLESLVCDDTRIPVDGFEVRLQELTKQDPKGGQTLLDQEFKTLSK
||||||.|.| || |  |    |....   .|.  .. |.|||.  ||
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegysk
0049260 (Phosphotyrosine protein) phosphatases II 207-391 3.7e-36 119.5 In-house 10-144 (152) alignment 
Range on Protein: 207-391
Range on HMM: 10-144/152.0
PTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWpdsgadetygeihveaksteerdfgvlrefiifkasedkrkltHFQFTKWPDKS
. | . ||  ||..|||||... .|... |.|.|.|  | ||| |.                                           ..... ||| .
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDhg

VPKQTSLFLRYMREVKKTyLADDSAPLLVHCSAGIGRSGVLIAMDSVVeqakrtGKVNVHGFVQAMRECRQNMVQTDEQYVFLHE
||. . |.|  .. ..|  . |.. | |||||||.||.|.|.|.. .        .|..  .|. .||.| ..|.. .|. ||.|
vpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046845 (Phosphotyrosine protein) phosphatases II 428-581 8.8e-36 119.1 In-house 2-159 (284) alignment 
Range on Protein: 428-581
Range on HMM: 2-159/284.0
LDQEFKTLSKISPDPSpLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPFGDYINASFVKSMGN---DSSPYYIVTQMPLPETVVNFWSLVYDY
|..||..| .. .... | .... . | ..||| ...|| ...| .|.|. .. . .||||||.|.  .    .... .|.||.|||.|| .|| .|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPTTIVMLNQLDKTD-STTGQYWPDGG-SVQYGPFTISTTSVEKNIGMIVRTLQVQLTE
. ..||||..|.  .     ||||. | ...||.||. ..|.|.. ...||||... ..
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlg
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 160-396 6.8e-35 115.2 In-house 55-288 (305) alignment 
Range on Protein: 160-396
Range on HMM: 55-288/305.0
NKPKNRYRNIlPYNNSRVVLevIDDDPYSDYINASYIDV--NPDHKFvlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA
.. ||||... | ..  .|.  .|. . |||| | |. .   |...|    |  .||  .|.|.|| |. |.|.  . |. |  |. | ||  ||| .  
aitknryqdv.pcqdqsavk..ldkpspsdyihanyvgcpmipekrf....icaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

D--ETYGEIHVEAKST---EERDFGVLREFIIFKA-SEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTyladdSAPLLVHCSAGIGRSGVLIAMD
.  |  . | ||  |     |||  .    . .    ..|  . |.|.|.|||. ||      |  .  .. .       |..|||||||||.| ..|..
eklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs.....kvpivvhcsagigrtgtivaie

SVVEQAKRTGK-VNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
 ..|.     .   .  .|.|.|. |   .|.| ||.|.|  .|. 
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
0039614 (Phosphotyrosine protein) phosphatases II 419-578 6.9e-35 116.3 In-house 25-177 (297) alignment 
Range on Protein: 419-578
Range on HMM: 25-177/297.0
QDPKGGQTLLDQEFKTLSKISPDpsplaIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPFGDYINASFVksMGNDS-SPYYIVTQMPLPETVVNF
 ... . |||..||..| .. ||     .... . | |.||| ...|| ...| .|..  .  .  ||||||.|   | |  .. .|.|| |||||| .|
lekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedF

WSLVYDYKPTTIVMLNQLDKTDSTTGQYWPDGGSvQYGPFTISTTSVEKNIGMIVRTLQVQ
| .|.... |.||||..|.  . .  ||||. |. .||.||. ...||.. |..|||| |.
wrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevt
0047943 (Phosphotyrosine protein) phosphatases II 420-580 8.2e-35 116.0 In-house 6-160 (273) alignment 
Range on Protein: 420-580
Range on HMM: 6-160/273.0
DPKGGQTLLDQEFKTLSKISPdpsPLAIRTGSKAECKKKNRDSSVLPIERNRAILqswysNEPFGDYINASFVksMGNDSSPYYIVTQMPLPETVVNFWS
... | ||| .||..| .. |   .| ...... | |.||| ...|| ...| .|     ...  ||||||.|   | .... .|.||.|||.|| .|| 
ekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwr

LVYDYKPTTIVMLNQLDKTDS-TTGQYWPDGG---SVQYGPFTISTTSVEKNIGMIVRTLQVQLT
.|.... ..||||..|.  .  .  ||||. |   |..||.||. ..|.|.. ...||||... .
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 444-579 8.5e-35 115.3 In-house 36-170 (297) alignment 
Range on Protein: 444-579
Range on HMM: 36-170/297.0
PLA-IRTGSKAECK---KKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMGNdsspYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTD
| | |... .|| |   .|.| . .||....| .|..   ..|  ||.||||||.. .     .| |||| ..|| .|| .|.|....||||||.....|
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaiv.nddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerd

STTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
    .||.| |....|  .. ..||..  |.| |.|.|. 
kkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 138-395 8.6e-35 114.7 In-house 14-267 (281) alignment 
Range on Protein: 138-395
Range on HMM: 14-267/281.0
IEEFEALPGVNTEQ-VTYAKLEENKPKNRYRNILPYNNSRVVLEV-IDDDPYSDYINASYIDVnPDHKFvlPTISHKGPKKNTVDDFWRMIWQEKIRVVS
 .||  |||    . .|  .   |. |||| ||   . ||| |.| . .   .||| | ||   |  |     |  .||||.|  |||||||||.   . 
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkr..gyiltqgpkketradfwrmiwqenttaiv

MVTKLEEVLKTKCECYWPDSG-ADETYGEIHVEA-KSTEERDFGVLREFIIFkaSEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKktylaDDSAPL
|. .. |  . ||  |.|    .   . .. |.   || .. .   |  . .    . | .||. . .|||  ||. . ..|. .|...       |.| 
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkir.....arstpp

LVHCSAGIGRSGVLIAMDSVVEQAKR-TGKVNVHGFVQAMRE-CRQNMVQTDEQYVFLHEAVLE
..|||||.|||| |.|..  ..  .      ...  |  .|   |   ||| .||... . .|.
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 138-393 1e-34 114.5 In-house 30-286 (310) alignment 
Range on Protein: 138-393
Range on HMM: 30-286/310.0
IEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEvIDDDPYSDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIRVVSMV
. ..  |   .   .||   ...  |||| ...  ..||| |. ||   | ||| | |.  |   .     |  .|| . |. ||||||.||.   . ..
vkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstf...icsqgplqhtiidfwrmifqeraesilll

TKLEEVLKTKCECYWPDSGADETYGEIHVEAKSTEERDFGVLREFIIFKA----------SEDKRKLTHFQFTKWPDKSVPKQTSlflrymREVKKTYLA
 |  |  . ||  |||  |  |||| | |   |    .| .    . |              .. ...  .. .|||. || .          | .  ||
ckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrlla

D-DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAV
.    | .||||||..| .|..|..  .....|  ||...  .  ..  |   .||. ||....   
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
0040438 (Phosphotyrosine protein) phosphatases II 424-578 1.7e-34 114.9 In-house 16-164 (317) alignment 
Range on Protein: 424-578
Range on HMM: 16-164/317.0
GQTLLDQEFKTLSKISPDpsplAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSnEPFGDYINASFVksMGNDSSPYYIVTQMPLPETVVNFWSLVYD
. |.| .||..| ....|     ...... | |.||| ...|| ...| .|..  .  .  ||||||.|   | . .. .|.|| |||.|| .|| .|..
dftalleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvwe

YKPTTIVMLNQLD-KTDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQ
.. |.||||..|. . . .  ||||.|....||.||. ..|.|.. |...|||.|.
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleve
0045450 (Phosphotyrosine protein) phosphatases II 416-580 2.2e-34 115.0 In-house 17-188 (307) alignment 
Range on Protein: 416-580
Range on HMM: 17-188/307.0
LTKQDPKGGQTLLDQEFKTLSKISPDPsPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPFGDYINASFVKS------MGNDSSPYYIVTQMP
| ..... . |.| .||..| .. ... .  ...... | |.||| ...|| ...| .|.|  .. . .||||||.|.        | |..  .|.|| |
lvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-TTGQYWPDGGSV-QYGPFTISTTSVEKNIGMIVRTLQVQLT
||||| .|| ...... |.||||..|.  ..    ||||| |.. .||.||. ..|.|.  |..|||| |. .
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 427-578 2.7e-34 113.4 In-house 20-167 (315) alignment 
Range on Protein: 427-578
Range on HMM: 20-167/315.0
LLDQEFKTLskisPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKP
|. .||. |    ||| .   |.. . .  ||||   .||....| .|.    ..|  ||||||..||. .| .  || .|.||. .| .||..|...|.
lfseefhdl....pdPdiyrqrvaretinfkknryknilPldsarvklev.iddsPdsdyinasyiksvdddka..yiasqgPlkasvddfwrmvlqekv

TTIVMLNQLDKTDS-TTGQYWPD--GGSVQYGPFTISTTSVEKNIGMIVRTLQVQ
|||||...... |     |||||  . ||..| . ... |.| . ....| | ..
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 135-395 1.7e-33 110.7 In-house 22-285 (305) alignment 
Range on Protein: 135-395
Range on HMM: 22-285/305.0
LELIEEFEALPGVNT-EQVTYAKLEENKPKNRYRNILPYNNSRVVLEVidDDPySDYINASYIDVNPDHKFVlptISHKGPKKNTVDDFWRMIWQEKIRV
  | .|| |.  .|  |..   |  ... ||||...   .| || ||     |  .|| | |.    . |     |  . | ..|  ||| | .|.|.  
aglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkleg..pwp.heyihanyvstptnpkrf...ictqaplektcadfwymclqdkvea

VSMVTKLEEVLKTKCECYWPDSGAD-----ETYGEIHVEAKSTEERDFG------VL-REFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREV
. |. .| |    ||  |..    |     |    | |  .|... .|       |   ...|  . |..|| ||. .  |||. ||      |  . . 
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka

KKTyladdSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVN-VHGFVQAMRECRQNMVQTDEQYVFLHEAVLE
. .       |. |||||||||.| .. .. ...|     ...  .  .| .|| |.| .|||.||.|.|. .|.
rps.....kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
PTPc_DSPc_SM00012 294-395 2.4e-33 109.8 In-house 2-105 (105) alignment 
Range on Protein: 294-395
Range on HMM: 2-105/105.0
LTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADD-SAPLLVHCSAGIGRSGVLIAMDSVVEQAKRT-GKVNVHGFVQAMRECRQNMVQTDEQYVFLHE
..|...|.|||..||.... .|...|.||| . . . |.|..||||||.||.|...|.| ...| ... ..|..  .|...|. |..||||.|||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0036941 (Phosphotyrosine protein) phosphatases II 420-580 2.4e-33 111.1 In-house 7-162 (297) alignment 
Range on Protein: 420-580
Range on HMM: 7-162/297.0
DPKGGQTLLDQEFKTLSKISPdpsPLAIRTGSKAECKKKNRDSSVLPIERNRAILqswysNEPFGDYINASFVksMGNDSSPYYIVTQMPLPETVVNFWS
... . .|| .||..| .. .   .  ...... | ..||| ...|| ...| .|     ...  ||||||.|   | | .  .|.|| |||.|| .|| 
ekllflalllkefeellplll...lgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWr

LVYDYKPTTIVMLNQLDKT-DSTTGQYWPDG--GSVQYGPFTISTTSVEK--NIGMIVRTLQVQLT
.|.... |.||||..|.     .  ||||.   .|..||.||. ..|||.  . ....|||.|. |
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt
0043336 (Phosphotyrosine protein) phosphatases II 418-579 4.6e-33 110.3 In-house 12-166 (278) alignment 
Range on Protein: 418-579
Range on HMM: 12-166/278.0
KQDPKGGQTLLDQEFKTLSKISPdpspLAIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVksMGNDSSPYYIVTQMPLPETVVNF
..  ....||| .||..| .. .      .... . | |.||| ...|| ...| .|.. .....  ||||||.|   | . .. .|.|| |||||| .|
lelllnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsl.lggdldsdYinAsyv..dgynvprkfiatqgPlpetvedF

WSLVYDYKPTTIVMLNQLDKTD-STTGQYWPdGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
| .|.... ||||||..|.  .  .  |||| |||..||.||. ....|.. ...|||| |  
wrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 457-577 7e-33 108.5 In-house 45-165 (515) alignment 
Range on Protein: 457-577
Range on HMM: 45-165/515.0
KKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDST-TGQYWPD--GGSVQ
||||   .||....| .|.    ..|  ||.|||...|. || .  || .|.|.. .| .||.||.....|||.|...| . |    |.||||  | ||.
kknryknilPydsvrvklev.indnPhsdyfnasyipsfdndka..yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YGPFTISTTSVEKNIGMIVRTLQV
.| . ... |.|   |.| |.|.|
fGsikvelvsleactggikrkltv
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 422-580 1.4e-31 104.7 In-house 17-171 (288) alignment 
Range on Protein: 422-580
Range on HMM: 17-171/288.0
KGGQTLLDQEFKTLSKISPDPSplaIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMGndSSPYYIVTQMPLPETVVNFWSLV
. ..| . .|...|...  . |     .|..|. .||||   .||.. .|  |.    .|.  ||||||.... .  ..  || || ||..|| .|| ||
arnrtgfseeynsLaalektks...vtagrlavnakknRyrnilpyDekrvklkk.leeeagaDYinasyidgek..kkkkyiatqgPladtvndfWelv

YDYKPTTIVMLNQL-DKTDSTTGQYWPDGGS-VQYGPFTISTTSVEKNIGMIVRTLQVQLT
|..| .|||||..| .. ... ..||||..  ..|| .|.  .....   ...|.| .. .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk
DSPc_SM00195 428-581 1.7e-31 104.9 In-house 2-153 (263) alignment 
Range on Protein: 428-581
Range on HMM: 2-153/263.0
LDQEFKTLSKISPDPsplAIRTGSKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMgnDSSPYYIVTQMPLPETVVNFWSLVYDYKPT
|..||..| .  ..     .... | . |.||| . .||....| .|..   ...  |||||...|    ...  ||.||.|||.||  || .|.. | .
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkke.ekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvk

TIVMLNQLDK-TDSTTGQYWPDG--GSVQYGPFTISTTSVEKNI-GMIVRTLQVQLTE
.||||.. ..    .  .|||.   |. ..| ... ...|||    .|.|||... ..
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkeg
PTPc_SM00194 428-581 1.7e-31 104.9 In-house 2-153 (263) alignment 
Range on Protein: 428-581
Range on HMM: 2-153/263.0
LDQEFKTLSKISPDPsplAIRTGSKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMgnDSSPYYIVTQMPLPETVVNFWSLVYDYKPT
|..||..| .  ..     .... | . |.||| . .||....| .|..   ...  |||||...|    ...  ||.||.|||.||  || .|.. | .
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkke.ekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvk

TIVMLNQLDK-TDSTTGQYWPDG--GSVQYGPFTISTTSVEKNI-GMIVRTLQVQLTE
.||||.. ..    .  .|||.   |. ..| ... ...|||    .|.|||... ..
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkeg
0044763 (Phosphotyrosine protein) phosphatases II 171-393 3.2e-31 103.7 In-house 1-167 (178) alignment 
Range on Protein: 171-393
Range on HMM: 1-167/178.0
PYNNSRVVLEVIDDDPYSDYINASYIDvnpDHKFVLPTIShkgpkkntvDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGAdetygeihveaks
|. ..||.|. . . ..|||||||.|.   .. .. .  .          |.........|... ..|.  |  . ||  |||..               
pldrtrvllsnleglersdyinaseil...pglylgslpp.........addlellkelgithivnlteelelgflkcdpywpeeag.............

teerdfgvlrefiifkasedkrklTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYlADDSAPLLVHCSAGIGRSGVLIAMDSVVEQakrtgKVNVHGFVQ
                         ..... .|| .||  .. ||. .. ... . ...  | |||||||.||||.|.|.. . ..     .....  ..
........................iqylhipipDhgvpdllehflefvefieeal.dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

AMRECRQnMVQTDEQYVFLHEAV
 .||.|  .|....|. .|.|  
lvrerRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 147-399 3.7e-31 103.2 In-house 22-272 (285) alignment 
Range on Protein: 147-399
Range on HMM: 22-272/285.0
VNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDddpySDYINASYIDVNPDHKFVlpTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKT
    ..||.  | |   ||| ..   ...||||.  |     ||| ||.. .    .     |. .||  .|. |||.||.||||  | |.  | |    
ymppnctytayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqst..yittqgplpetlsdfwhmiyqekiayvlmlctlfeggve

KCECYWPDS-GADETYGEIHVEA-KSTEERDFGVLREFIIFKASED----KRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTylADDSAPLLVHCSAG
||  |.|.  |    .|.  .   .  ||   | . . .    .||       . | |   |||.  |...  ..   . |||        |. ||||||
kcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsag

IGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVC
.||.  .. .|    .     ....   |. ||  | . ||.  |..||.  ..| .. 
vgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 159-399 1.3e-30 101.4 In-house 42-273 (288) alignment 
Range on Protein: 159-399
Range on HMM: 42-273/288.0
ENKPKNRYRNILPYNNSRVVLEvidDDPySDYINASYIDvnpDHKFVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDS-GA
.|  ..||.|.   . .|| |.   |||   ||.|  .     .|.    |  . | . |.. .|.|. .. .. . |...| |  | | . |.|   | 
anptrdryenlprcditrvkls...ddp.dfyiaanvvs...sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe

DETYGEIHVEAKSTEeRDFG---VLREFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVkktylADDSAPLLVHCSAGIGRSGVLIAMDSVV
   .| .    |     |     ..  . | |  |.|  . .  . .|.|..||..   .|| .  .      .   |..||.|||.||.| || .  ..
karigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

EQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVC
|... .  . .. ... .|| | . .||  ||...|  ||| |. 
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 412-581 1.6e-30 101.1 In-house 6-167 (287) alignment 
Range on Protein: 412-581
Range on HMM: 6-167/287.0
RLQELTKQDPKGGQTLLDQEFKTLSKISPDPSPLAIRTGSKaeCKKKNRDSSVLPIERNRAILQswysnEPFGDYINASFVKSMGNDssPYYIVTQMPLP
.. |....... |..   . |..| ... ..  . .   |.   |.||| . .|. . .| .|.     .   |||||.|...  ..    .|... |. 
kfgefvakghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk.....gehpdyinavfidgykek..kafiiaesPmf

ETVVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLTE
.|..||| |. | ..|.|||| |.  .| .   ||||.. || .|...|. .. |.| |.|.|.|.|. ..
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn
0045098 (Phosphotyrosine protein) phosphatases II 440-580 2e-30 101.6 In-house 18-144 (278) alignment 
Range on Protein: 440-580
Range on HMM: 18-144/278.0
PDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAIlqswysnepfgDYINASFVKSMgndsSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-DKT
. ..|  | .. . ....||| ...||....| .           ||||||....     .. .|.|| |||.|| .|| ...... |.||||..| ...
llgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

DSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLT
     ||||.|||..||.||. ..|.| .  ...||| |. .
rekcaqywpeggsltygdftvtllseevlddytlrtllvtnl
0051082 (Phosphotyrosine protein) phosphatases II 186-394 2.8e-30 100.3 In-house 1-150 (151) alignment 
Range on Protein: 186-394
Range on HMM: 1-150/151.0
PYSDYINASYIDVNpdhkfvlpTISHKGPkkntVDDFWRMIWQEKIRVVSMVTKLEEVLktKCECYWPDSGadetygeihveaksteerdfgvlrefiif
|.|||||.||.. .         .   ||     .||........|... .....||    .| .|.|. |                             
plsdyinfsyvtgg........lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.............................

kasedkRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKtylaDDSAPLLVHCSAGIGRSGVLIAMDSVVEQakrtgkVNVHGFVQAMRECRQNMVQTDEQ
      ....|.... ||| ..|  .  .|...... .    ... |.|||||||.||.|.|.|.. . ..      |..   .. .|..| ..||. .|
......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YVFLHEAVL
..|.. |.|
flfqlfall
Y_phosphatase Protein-tyrosine phosphatase 456-582 5e-30 100.0 Pfam-A 2-128 (235) alignment 
Range on Protein: 456-582
Range on HMM: 2-128/235.0
KKKNRDSSVLPIERNRAILQSWYSNEPfgdYINASFVKSMGNdsSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKT-DSTTGQYWP--DGGSV
||||| ...||....|  |..  ...    ||||..||.  .  .  .|.||.||..|.  || .|...| ..||||..|..  . .. ||||  ...|.
kkknRykdilpydktrvklkgsegpsd...YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

QYGPFTISTT-SVE-KNIGMIVRTLQVQLTET
.|| ... .. ... .. ....|.|... ...
tygdikvelkekekedekeytlrklelkkkke
Y_phosphatase Protein-tyrosine phosphatase 456-582 5e-30 100.0 In-house 2-128 (235) alignment 
Range on Protein: 456-582
Range on HMM: 2-128/235.0
KKKNRDSSVLPIERNRAILQSWYSNEPfgdYINASFVKSMGNdsSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKT-DSTTGQYWP--DGGSV
||||| ...||....|  |..  ...    ||||..||.  .  .  .|.||.||..|.  || .|...| ..||||..|..  . .. ||||  ...|.
kkknRykdilpydktrvklkgsegpsd...YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

QYGPFTISTT-SVE-KNIGMIVRTLQVQLTET
.|| ... .. ... .. ....|.|... ...
tygdikvelkekekedekeytlrklelkkkke
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 151-389 5.7e-30 99.1 In-house 41-273 (301) alignment 
Range on Protein: 151-389
Range on HMM: 41-273/301.0
QVTYAKLEENKPKNRYRNIlPYNNSRVVlEVIDDDPySDYINASYIDVNP-DHKFvlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCE
..| .    .| |.|| .. | . |  | |||.|      | | .|. .   |.|    |. .|| ||| .||| |. | ..  . |...  | |..|||
hitesyaylpkdkhryptv.PckPstav.evivdGk.rvPihanwiptsGhphrf....iatqgPlkntsedfwamlvqydvekivmlgqkvekleekce

CYWPDSGADE-TYGEIHVEAKSTE--ERDFGVLREFIIFKASE--DKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTyladdSAPLLVHCSAGIGRS
 | | . ...   |  ... |..|   ..  . |.. .  ...  . | .||.|...|.|. |||        |  |||.       |..||||||||||
eylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrs

GVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFL
  .|. . .  . .   ....   .. .|| | | ||| .|  ..
vafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 450-578 2.1e-29 97.5 In-house 4-129 (250) alignment 
Range on Protein: 450-578
Range on HMM: 4-129/250.0
GSKAECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKSMGNDssPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDSTTGQYWPDG
. | . |.|||.. .....  | .|..  ...   |||||||.... .     .|.|| ||..|...|| .|...| .|||||..|  .. |  ||||  
akkpqnkeknryadiialdssrvvLekekgdk.esdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GSVQYGPFTISTTSVEKNIGMIVRTLQVQ
.. .||  |.|  | |.   ...|.|.. 
kaekyGdvtvsllskeefadytkrklkls
0040439 (Phosphotyrosine protein) phosphatases II 449-579 2.7e-29 97.9 In-house 5-133 (249) alignment 
Range on Protein: 449-579
Range on HMM: 5-133/249.0
TGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVksMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKT-DSTTGQYWP
.... | |.||| ...|| ...| .|.. ... . .||||||..   | .... .|.|| |||||| .|| ...... |.||||..|.     .  ||||
vallpenkdknrypdilpydhsrvklsi.lpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
.|||..|| ||. ..|||.. ...||||... 
lggsleygdftvtllsvevkddytvrtleltn
subfamily_PTPRG_pd Subfamily PTPRG 405-579 4e-29 96.2 In-house 2-170 (563) alignment 
Range on Protein: 405-579
Range on HMM: 2-170/563.0
PVDGFEVRLQELTKQdpkgGQTLLDQEFKTLSKISpDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPFGDYINASFVksMGNDSSPYYI
||. |.  . .|  .    |.. ...||. | . .  .. | . . .| | |.|||........| |  |..   ..   |||||...  .|   |  .|
pvkefakhvaslhad....gdigfseefealqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyi..dGyqkskafi

VTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-DKTDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
.|| ||..|.  || .... . ..|||. .| ...     .|||  .|..|| ...  .. |. .   ||||... 
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlvikn
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 437-578 5.9e-29 96.2 In-house 30-170 (325) alignment 
Range on Protein: 437-578
Range on HMM: 30-170/325.0
KISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMGNDSspYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLD
.. |   . | ..  | | |.|||   |......|..|..   ..|  ||||||....  .     .. .|.||..|. ..| ||.|.. . .|.||.||
gllpsddgiakkvamkpenkaknrfknvvaldksrvvlet.kkddpssdyinasylrddkkkd..vflaaqaPltatindlWrlvldWrcsvvvvlneld

KTDSTTGQYWPDG--GSVQYGPFTISTTSVEKNIGMIVRTLQVQ
. .    .|||.    |...|.. ..  ..|.    . | |.|.
lgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk
subfamily_PTPRK_pd Subfamily PTPRK 451-579 8.1e-29 95.4 In-house 39-164 (314) alignment 
Range on Protein: 451-579
Range on HMM: 39-164/314.0
SKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMgnDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPDG
 | | ..|||   .|. .| | .|..   ..|  |||||... |     .  .|||| ||.||| .|| ||||.. ..||||..| ..      .|||. 
kkdenreknrsgdilaydrsrvfliti.dgdpssdyinaalidsy..krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GSVqYGPFTISTTSVEKNIGMIVRTLQVQL
..| ||.. .   ..| .  ..||...|. 
tev.ygdikvelvetellaelvvrifrvek
0042113 (Phosphotyrosine protein) phosphatases II 450-579 1.7e-28 95.1 In-house 4-131 (245) alignment 
Range on Protein: 450-579
Range on HMM: 4-131/245.0
GSKAECKKKNRDSSVLPIERNRAILQsWYSNEPFGDYINASFVksMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-TTGQYWPD
... | |.||| |..|| ...| .|. ....... ||||||.|   | . .| .|.|| |||||| .|| ...... ||||||....  .  .  ||||.
allpenkdknrysdilpydhtrvkls.pdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

GGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
|.|..|| ||. ..|.|.. ...||||.|. 
gesltygdftvtllseehlddytvrtlevtn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 158-406 2.8e-28 93.9 In-house 17-257 (290) alignment 
Range on Protein: 158-406
Range on HMM: 17-257/290.0
EENKPKNRYRNILpYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVLPT-ISHK--GPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKT----KCEC
.... ..|... |  ...||||..      .||| |... .  . ...|     .|    .. |. .|| |. |||.. | |. . ||  .      |. 
kkhemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPDSGA-DETYGEIHVEAKSTEERDFGVLREFIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKtyladDSAPLLVHCSAGIGRSGVLIA
| |.|   . ... . |. || |. |    || ..    | . ..|| ..  | . .|...| ..|  .. ||.       .| .|||  || || .| |
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvka.....sktpvivHcvdGiSrsAalaa

MDSVVEQAK-RTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLeslvcddtripV
..         .|.|...  ..|.|. |.......... |   ...           .
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...........l
subfamily_egg_pd Subfamily egg 146-395 4e-28 93.0 In-house 26-271 (307) alignment 
Range on Protein: 146-395
Range on HMM: 26-271/307.0
GVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKfvlPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVlk
 |. . .| |  ..|. | | . .   . ||| ||.       |.| | ... .|        |  . | ||||||||||..||... . |.|   |   
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkplln...efilaqaplkntvddfwrmvfqeevqyivmltsrkes..

TKCECYWPDSGADET---YGEIHVEAKSTEER---DFGVLREFIiFKASEDKRKLTHFQFtKWPDKSvpkQTSLFLRYMREVKKTyladdSAPLLVHCSA
 .|| ||| . .|      | ...|.   ...    | | .  .   . ...| | |.|   .   |   .    || .| ...      | | .|..  
erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnss...dvysplrvlrklrnl.....skpvvvqdil

GIGRSGVLIAMDSVVEQAKR--TGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVL---E
|. ....|.|..  . .  |  . |  |   |. .|  |.  |..  .|.|..  ||    
GvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 432-578 4.8e-28 92.8 In-house 12-153 (283) alignment 
Range on Protein: 432-578
Range on HMM: 12-153/283.0
FKTLSKISPDPSPLAIrtGSKAECKKKNRDSSVLPIERNRAILQSWYSnepfgDYINASFVK-SMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIV
...| ..|  . .  |   |  | |.|||   ..| ...|  |.|        |||||.|.  |  .. .  ||..| || .|||.|| .|.| | |.||
revlkrlsvpdldadi..asadenkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLNQLDKT-DSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQ
|| .|    .    ||||  ||..||.||..      .  .|.. | ..
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllr
subfamily_CG7180_pd Subfamily CG7180 432-578 1e-27 91.6 In-house 19-162 (296) alignment 
Range on Protein: 432-578
Range on HMM: 19-162/296.0
FKTLSKISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPTTIVM
.| . |. |  .    ..| ..| ..||||  |.| . || .|..   .| . |||||..| |.  .    ||||..|  ||| .||.|||| .  ..|.
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGee.ksdYinavyvdsflkkke..yivteapkketvdefWrlvydeeisavvv

LNQLDKTDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQ
| .         .|||  .  |||.. . ......   .  ||....
Ltktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfklt
subfamily_PTPRA_pd Subfamily PTPRA 446-578 1.4e-27 91.4 In-house 49-179 (330) alignment 
Range on Protein: 446-578
Range on HMM: 49-179/330.0
AIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDK-TDSTTGQ
.. . || | |.|||   .|| . .| ||.   . ..  |||||||..  |     ..| .| |. ||| .|| .....| .||||| .|..  ..   |
tlelaskeenkeknrvvnilPydfsrvilsv.keGveesdyinasfid..GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaq

YWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQ
|||| |.| ||  ...   ..  . . || . ||
ywPdeGlvtyGnirvevedetvlvdytvrkflvq
subfamily_CG42327_pd Subfamily CG42327 136-324 1.5e-27 91.1 In-house 6-193 (319) alignment 
Range on Protein: 136-324
Range on HMM: 6-193/319.0
ELIEEFEALPGVNTEQVtyAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYIDVNPDHKFVlpTISHKGPKKNTVDDFWRMIWQEKIRVVS
...|||. || . ..    .     |.|.|. |..|  ..||||. | ||. . |..|||.    | .     |. . . ...  ||||..|. . ||. 
dvaeefrdlPqliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapns..yiaaqvsledsssdfwrtvweqqsrviv

MVTKLEEVLKTKCECYWPDSGA---DETYGEIHVEAKSTEERDFGVLREFIIFKAS-EDKRKLTHFQFtKWPDKSVPKQTSLFLRYMREVKKT
 .|.| |    .|  |.| . .    ..||.| |  |  | .|  ..  ... .   |  |.|||. . ||..  || . . ..  . ||...
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_PTPN23_pd Subfamily PTPN23 419-582 2.5e-27 90.4 In-house 8-167 (288) alignment 
Range on Protein: 419-582
Range on HMM: 8-167/288.0
QDPKGGQTLLDQEFKTLSKISPDPspLAIRTGSKAEC-KKKNRDSSVLPIERNRAILQswysnEPFGDYINASFVKSMGNdSSPYYIVTQMPLPETVVNF
.   .|.| ||..|| | .          |. . |..  .|||   .|| ..||  |.     .   |||||||||..    .| .|.|| ||..|.  |
rkmldgktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlsp.gcPdfiatqaPlqstlnDF

WSLVYDYKPTTIVMLNQLDKTDST-TGQYWPD--GGSVQYGPFTISTTSVEKNIGMIVRTLQVQLTET
|..||. |  .|||| . .... . . .|||   | .|..|.....  ||..   .. |.|...  ..
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 406-577 6.3e-27 89.7 In-house 13-175 (319) alignment 
Range on Protein: 406-577
Range on HMM: 13-175/319.0
VDGFEVRLQELT-KQDPKGGQTLLDQEFKTLSKISPdpsPLAIRTGSK-AECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKsmGNDSSPYY
|. |..  |.|. |.| .  .| |  ||. ..|...   .|| .| .   . | |||   .|. ..|.  |.     | | ||||||||.  |  .   |
vpdfpayyqqlsnksdfdddltklevefrracklgv...nladqtfanldqnkdknriinilafdknvvklerliGee.fsdyinasfvt..Gyqrkdky

IVTQMPLPETVVNFWSLVYDYKPTTIVMLNqldktDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQV
| .| ||..|. .|| ....|. .|||.|           ||||  . .... | .. .|||.    .|| ...
iaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdiel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 447-578 7.2e-27 89.1 In-house 41-169 (315) alignment 
Range on Protein: 447-578
Range on HMM: 41-169/315.0
IRTGSKAECKKKNRDSSVLPIERNRAILQsWYSNEPFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDSTTG-QY
...  | | |.|||   ... .. |. |     |.|  ||.||.|..  | .    || .| |....| .|| ||.... ..||||..| . .     .|
ldvakkienkqknryiniiaydksrvqlp.llendphsdyvnanfid..Gynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky

WPDGgSVQYGPFTISTTSVEKNIGMIVRTLQVQ
|||   | ||..|..  | |.|  . |||| | 
wpdk.kviyGkitvtrkseevnteytvrtlsvv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 138-399 8.3e-27 88.7 In-house 22-278 (312) alignment 
Range on Protein: 138-399
Range on HMM: 22-278/312.0
IEEFEALPGVNTEQVTYAKLeENKPKNRYRNILPYNNSRVVLEviDDDPYsdYINASYIDVNPDHK-FVlptiSHKGPKKNTVDDFWRMIWQEKIRVVSM
  |. |.  . ..    | |   |  ||| ||  ..  |  |    |. .  || | .. .    . ||    . .|| .||.  ||..        . .
tkeykavgnivsdsectafl.kfkdlnrypniqcwdrgrftla..gdenf..yihanfvkictkperfv....ctqgplentcthfwqlalslgstsiil

VTKLEEVLKTKCECYWPDSGA----------DETYGEIHVEAKSTEERDFGVLRefIIFKASEDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKtyl
.. . |    ||  |  |  .           |   || .  || .     ||.  .. ||. .. || |.|.. |||. .|      || .  |||   
lcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlk..vvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...

adDSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLVC
  |  |.. |||||.||.| |. ..|..   .   | ||.     .|  |   |..  |||.   .||| | .
..dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 419-582 1.7e-26 87.7 In-house 13-173 (290) alignment 
Range on Protein: 419-582
Range on HMM: 13-173/290.0
QDPKGGQTLLDQEFKTLSKISpdpSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEP-FGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNF
.. . |..   ..||.| . .   |. .. .|   . |..|| . ... . || .|.   ...    .||||...|   .. .  ||.|| |...|.|.|
nghakgnegfrnqfkmldsge...sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq..yiatqgpvsntlvdF

WSLVYDYKPTTIVMLNQLD-KTDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLTET
|.|... | | |||| .   .   .  ||||| .. .||.|.|  .. |.  ..| |.|.|. ...
WkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkns
subfamily_PTPN6_pd Subfamily PTPN6 409-579 2.5e-26 87.4 In-house 9-178 (306) alignment 
Range on Protein: 409-579
Range on HMM: 9-178/306.0
FEVRLQELTKQDPKGGQTLLDQEFKTLSKISpDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQswYSNEPFGDYINASFVKSMGNDSSPYYIVTQM
 | | .||.|.. . ... . .||..|..     . |  . |.|.| |.|||  ..|| . .| ||.   .. |  |||||...|.  ..|. .|| || 
ieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqg

PLPETVVNFWSLVYDYKPTTIVML-NQLDKTDSTTGQYWPDGGS-VQYGPFTISTTSVEKNIGMIVRTLQVQL
 |..|| .||..|.. . . |||. ...... .   .||||  .  .||  .....| ...   |.|.|.|. 
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk
0037934 (Phosphotyrosine protein) phosphatases II 451-580 4.6e-26 87.3 In-house 6-126 (243) alignment 
Range on Protein: 451-580
Range on HMM: 6-126/243.0
SKAECKKKNRDSSVLPIERNRAILqswysnEPfGDYINASFVKSMgndssPYYIVTQMPLPETVVN----FWSLVYDYKPTTIVMLNQLD-KTDSTTGQY
.. | ..||| |..|| ...| .|      |. .|||||....       |..|.||.|||||| .    || ...... |.||||..|. ..     ||
llpenlsknrysdilpydhsrvkl......eg.sdyinanliyvt.....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPdgGSVQYGPFTISTTSVEKNIGMIVRTLQVQLT
||  |.|.||.||. ..|.|   ...||||... .
wp..gevtygdftvtllseehlddytvrtlllenl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 429-580 7.9e-26 85.9 In-house 25-171 (305) alignment 
Range on Protein: 429-580
Range on HMM: 25-171/305.0
DQEFKTLSKIsPDPsplaIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKSMgnDSSPYYIVTQMPLPETVVNFWSLVYDYKPTT
....|.| .  ...    |  |.| . |.||| ... . . .| ||.   |..   ||||||.|..   ...  |||.| ||..||..|| |....|..|
eaqykslyee.ees....idvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveekvst

IVMLNQLD-KTDSTTGQYWPDGGSV--QYGPFTISTTSVEKNIGMIVRTLQVQLT
|||| .|    ..   ||||.  .   ..|.|..  .| ..  . | | |..   
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisie
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 424-579 1.1e-25 85.4 In-house 21-170 (319) alignment 
Range on Protein: 424-579
Range on HMM: 21-170/319.0
GQTLLDQEFKTLSKISPDpsplAIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMGNDSspYYIVTQMPLPETVVNFWSLVYD
|.|||..|||.|.. ..|     ... || | ||||| . .|...| | .|.. . . .  |||||||. .  . .   .| || || .|. .|| .|..
getllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlse.ldgvegsdyinasfidgyqere..kfiatqaPlentiedfWrmvWe

YKPTTIVMLNQLD-KTDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
..  ..|||..|  | .    .|||.   ..|| ...   . |.  ..|.| |... 
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 439-582 1.3e-25 85.1 In-house 30-171 (318) alignment 
Range on Protein: 439-582
Range on HMM: 30-171/318.0
SPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLD-K
|....  .     .   |.|||   .|. .. |  ||   ..|.  |||||...   |. ..  || .| |||||. .|| .|.. . ..|||| |.  .
srseetvtslkslepvnkaknryanilaydhtrvkLqml.egeegsDyinanyid..GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeer

TDSTTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLTET
.     .|||. || .||  ..  ..  .   ...|...|. ||.
gkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrtee
subfamily_PTPRB_pd Subfamily PTPRB 423-580 5.9e-25 82.9 In-house 22-175 (293) alignment 
Range on Protein: 423-580
Range on HMM: 22-175/293.0
GGQTLLDQEFKTLSKISPDpspLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVY
  .. . .|...|...  |    |. . ..|. ..||| . .|| . .|  |..  ..|.  |||||....  |. |   .|.|| |||||| .|| .|.
dsdlrfseeyeelkavgkd...qavkaaelavnraknrytnilpydhsrvkLaal.kdesgsDYinanyip..gynsprefiatqGPlpetvddfWrmvw

DYKPTTIVMLNQL-DKTDSTTGQYWPDG-GSVQYGPFTISTTSVEKNIGMIVRTLQVQLT
. | ..|||| || .|      .|||.   .|.||  ... .. |.    ..|.|... .
ekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkieke
subfamily_Ptp69D_pd Subfamily Ptp69D 425-579 6.5e-25 82.9 In-house 21-170 (307) alignment 
Range on Protein: 425-579
Range on HMM: 21-170/307.0
QTLLDQEFKTLSKIspdPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKSMGNdsSPYYIVTQMPLPETVVNFWSLVYDY
. .| .|...| .     ...  ... | | . |||   . . ...| .|.    .|   |||||||.|.  .  .  .|. | |. .|. .|| .. . 
dfglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingke.dsdYinasfikgyke..kkkfiaaqdPveatigDfWRmiaeq

KPTTIVMLNQLDKTDS-TTGQYWPDGGSVQYGPFTISTTSVEKNIGMIVRTLQVQL
. |.|||| .|. ..     .|||.   ||||   . . | ||    | |.|.|  
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvsk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 453-577 1.4e-24 82.1 In-house 23-139 (284) alignment 
Range on Protein: 453-577
Range on HMM: 23-139/284.0
AECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNqldktDSTTGQYWPDGGSV
 . | |||   .|. ..|.  |.    .| | |||||||..  |  .   || || ||..|. .|| ....|. .|||.|      .    ||||  . .
dqnkdknrighilafdknvvklerliGee.fsdyinasfit..GyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivi

QYGPFTISTTSVEKNIGMIVRTLQV
... | .. .|||.   ..|| ...
keerfkvkvdsveeseeyvvrdiel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 455-580 7.2e-24 79.3 In-house 28-157 (274) alignment 
Range on Protein: 455-580
Range on HMM: 28-157/274.0
CKKKNRDSSVLPIERNRAILQSWYSNEPFGDYINASFVKSMGNDSSpYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-TTGQYWPDGGSV-
 ..|||  ..|| |. | .|.|  |...  .|||| ..|  ...|   |. || |||.|| .|| ..|  . . |||| .|  ..     .|.||  .. 
sqtknryktilPnensrvllesessededssyinanyikGydeesk.ayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---QYGPFTISTTSVEKNIGMIVRTLQVQLT
   .|| . | .... .. .  ||.| .. .
iserygdveikvekiverndysvrklvlkyl
subfamily_PTPN12_pd Subfamily PTPN12 444-581 1.4e-23 78.2 In-house 29-167 (290) alignment 
Range on Protein: 444-581
Range on HMM: 29-167/290.0
PLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEpFGDYINASFVKSMGNdsSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLN-QLDKTDSTT
     .|.| | .||||   .|| . .|  |.   ..|   |||||.|.|   .  .  || .| |||.|. .|| ...... . .||.  ...      
vysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

GQYWPDG--GSVQYGPFTISTTSVEKNI-GMIVRTLQVQLTE
 .|||.    ....|.|...... ..   ....|||.|.  .
erYWpeegeeelefgefevtleeekavdddflirtLkveaqk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 136-394 2.1e-23 77.2 In-house 27-282 (302) alignment 
Range on Protein: 136-394
Range on HMM: 27-282/302.0
ELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDdpysDYINASYIDVnP--DHKFVLPTISHKGpKKNTVDDFWRMIWQEKIRV
|. .||...  . ..        .|  ||.  ..  ... .| ||   |    .|.||| ..| |   .. .|  . ...  .. |..||||..||||  
evkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvev.PeltrsiilaQlpkvd.sedsveeFWrmvfqekivs

VSMVTKLEEVLKtKCECYWP-DSGADETYGEIHVEAKSTEERDFGVlREFIIFKASE---DKRKLTHFQFTKWPDKSVPKQTSLFLRYMREV-KKTYLAD
| .. . ||. |   . ..|  ||. ..||.. |  .  |. .  .  ...|    |   .    .   .| |..|.||.. .   . . .| .|.  ||
vvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

DsaPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVL
.  ....    |.|| |.....  .||. ..  ..|..  |...|. | ..|.. .|||.|. |.|
e..ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 426-581 2.1e-23 77.9 In-house 15-166 (281) alignment 
Range on Protein: 426-581
Range on HMM: 15-166/281.0
TLLDQEFKTLSKISPDPSPLAIRTgskAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMGNDSspYYIVTQMPLPETVVNFWSLVYDYK
. . .|...|..|  | .  | ..    | ..||| | .   .  |  ..   ...   |||||.||... ..    ||.|| |.|...|.|| .|...|
aGfieeyeklaaigvdntataska...denvlknrYsnivaYDatrvkvtpn.eenkntDYinanfvpgykgek..eyiatqgPvPaslvafWqmvweqk

PTTIVML-NQLDKTDSTTGQYWPDGG-SVQYGPFTISTTSVEKNIGMIVRTLQVQLTE
 ..|||. .....      .||||.  ...|| .|...|. |..  .| |..... ..
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 209-390 3.5e-23 76.8 In-house 8-197 (199) alignment 
Range on Protein: 209-390
Range on HMM: 8-197/199.0
ISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA-DETYGEIHVEAKSTEE-RDFGVlREFIIF---KASEDKRKLTHFQFTKWP
|. . | ..|. |||.|.|.     . ||   .   ..    ||| . .    || . | .|.     |. .   .|.     |    |...|.||| | 
iatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdyti.taliltnnttappstreishyqftswk

DKSVPKqTSLFLRY---MREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQ--AKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLH
.|. |.  .||. .    ||| | |  .  ||..|||| | | .||..|.|  |      .|  |..    . .|..|  .. . ..| |..
ekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 209-390 4.1e-23 76.6 In-house 7-196 (198) alignment 
Range on Protein: 209-390
Range on HMM: 7-196/198.0
ISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSGA-DETYGEIHVEAKSTEE-RDFGVlREFIIF---KASEDKRKLTHFQFTKWP
|. . | ..|. |||.|.|.     . ||   .   ..    ||| . .    || . | .|.     |. .   .|.     |    |...|.||| | 
iatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdyti.taliltnnttappstreishyqftswk

DKSVPKqTSLFLRY---MREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQ--AKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLH
.|. |.  .||. .    ||| | |  .  ||..|||| | | .||..|.|  |      .|  |..    . .|..|  .. . ..| |..
ekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0048076 (Phosphotyrosine protein) phosphatases II 289-394 8.1e-23 76.1 In-house 42-140 (145) alignment 
Range on Protein: 289-394
Range on HMM: 42-140/145.0
EDKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLADdsAPLLVHCSAGIGRSGVLIAMDSVVEqakrtGKVNVHGFVQAMRECRQNMVQTDEQYVF
  .|. ...... ||| .||  ..|.|. .. ... . ..   | |||||||.||.|.|.|.. . .      .|...  .. .|..| ..|....|. |
llerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

LHEAVL
|.|..|
lyefel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 160-273 3.2e-22 73.7 In-house 47-167 (350) alignment 
Range on Protein: 160-273
Range on HMM: 47-167/350.0
NKPKNRYRNILPYNNSRVVLE--------VIDDDPYSDYINASYIDVN-PDHK--FVLPTISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKC
   ||||.|||||. ||| |.        .      .|||||.|. .. .  .       |. ..| ..|||||...| . |..|. ..|.. |    ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

ECYWPDSGADEtygeIHVEAKSTEE
. ||.. . |.    |.|  .|. |
yrYWqegsydd....itvklaskwe
subfamily_PTPN14_pd Subfamily PTPN14 436-579 5.3e-22 73.2 In-house 30-176 (300) alignment 
Range on Protein: 436-579
Range on HMM: 30-176/300.0
SKISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNepFGDYINASFVKSMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL
 .|..      . |..  | ..|||.  ||| | ||  |..   |    .||||| .|     ..  |||.| ||. || .|| .|.. . . |||| . 
eripkkredallstaklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

-DKTDSTTGQYWPDG----GSVQYGPFTISTTSVEKNIGMIVRTLQVQL
 ..    . .|.|.      .|..| | ..|  .|.   .| ..|... 
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkh
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 429-551 1e-21 71.8 In-house 23-147 (392) alignment 
Range on Protein: 429-551
Range on HMM: 23-147/392.0
DQEFKTLskisPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPTT
 .||. |    |.|     ... |   .||||   .||....| .|.    . |  ||.|||...|. |. .  || .|.| . .. .||..|.. ..||
feefhdl....pgpdiypqtvaqkeinlkknryknilpydsarvklev.iddipdsdylnasyipsfdneka..yiasqgpnaaslddfwrmvfqenvtt

IVMLNQLDKT---D--STTGQY----WPDGGS
|.|...|..    |   |  |.    ||| . 
iamvtklkegdkgddartvaqfhftewPdkdv
0048179 (Phosphotyrosine protein) phosphatases II 290-391 1.2e-21 72.4 In-house 45-139 (144) alignment 
Range on Protein: 290-391
Range on HMM: 45-139/144.0
DKRKLTHFQFTKWPDKSVPKQTSLFLRYMREVKKTYLadDSAPLLVHCSAGIGRSGVLIAMDSVVeqakrTGKVNVHGFVQAMRECRQNMVQTDEQYVFL
 .|  ...... ||| .||  ..|.|. .. ... .   .. | |||||||.||.|.|.|.. ..     . .....  .. .|..| ..|....|. ||
leregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

HE
.|
le
subfamily_PTPN3_pd Subfamily PTPN3 445-582 1.3e-21 71.8 In-house 31-167 (280) alignment 
Range on Protein: 445-582
Range on HMM: 31-167/280.0
LAIRTGSKAECKKKNRDSSVLPIERNRAILQSwysNEPfgDYINASFVKS--MGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQ-LDKTDST
||| .  |.|  .|||   .|| .  | .|..   .|   |||||..|.    ... .  ||.|| ||..|. .|| .|.. | ..|||| . ...    
laisaarkpenlsknryrdilpydatrvklke...set..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

TGQYWPDG-GSVQYGPFTISTTSVEKNIGMIVRTLQVQLTET
  ||||.   ...|| |..  .. ...  ...| | .. .||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdket
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 209-419 1.8e-21 71.4 In-house 39-237 (255) alignment 
Range on Protein: 209-419
Range on HMM: 39-237/255.0
IshkgpkknTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSgADETYGEIHVEAKSTEERDFGVLREFIIFKASEDKR---KLTHFQFTKWPDK
.        ||| |...| | |  || |.. ..|  . ||. |.|    ||     .|.  .|.     |||   |     .|.   ...|.... |..|
l........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfple.kdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiek

SVPKQTSLFLRYMRevkktyLADDSAPLLVHCSAGIGRSGVLIAMDSVVE------QAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESLvc
  |...   |  ..      .. || ...||||.|||||  .. ...|        .   |....   ... .|. |.  ..|  |  |    ||. .  
naPelareilnilk......vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv..

ddtrIPVDGFEVRLQELTKQ
     | . .| ..||. | 
....fpkgeleakyqeirks
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 427-581 5.4e-21 69.6 In-house 16-168 (301) alignment 
Range on Protein: 427-581
Range on HMM: 16-168/301.0
LLDQEFKTLSKISPDPSPLAIrtgsKAECKKKNRDSSVLPIERNRAILQSWYS-NEPFGDYINASFVKSMGNdsSPYYIVTQMPLPETVVNFWSLVYDYK
 .....|.|.. ..... . .    . | |. ||  .. ... || ||. . . .    .|||||..... .  .  .|..| |. .|.|.|| |....|
kfeeqykelkegedksctvgl....seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse..kkkfiaaqgpmkktlvdfWrliwqek

PTTIVMLNQLD-KTDSTTGQYWPDGG--SVQYGPFTISTTSVEKNIGMIVRTLQVQLTE
|..|||. .|. .| | . ||||..   | ..||||.  ..      ...| |.|....
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd
subfamily_PTPRN_pd Subfamily PTPRN 426-562 1.1e-20 68.6 In-house 29-162 (297) alignment 
Range on Protein: 426-562
Range on HMM: 29-162/297.0
TLLDQEFKTLSKISPDPSplAIRTGSKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMgNDSSPYYIVTQMPLPETVVNFWSLVYDYK
. |..|...| .   .||  .  .... .. |||| ..||| . .|  |..  ...   ||||||..    .  .| || || ||..|| .|| .|..  
drlekewealcayeaeps..tkevakaeknvkknrskavlpydhsrvklkee.asaeksdyinasaildh.dprapayiatqgplastvadfwqmvweqG

PTTIVMLNQLDKTDSTTG-QYWPDGGSVQYGPFTISTT
 . ||.| .|.... .   .|||| ||  |. . .   
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 213-396 1.7e-20 67.7 In-house 98-287 (302) alignment 
Range on Protein: 213-396
Range on HMM: 98-287/302.0
GPKKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDS-GADETYGEIHVEAKSTEE--RDFGVLREFIIFKA--------SEDKRKLTHFQFTK
 |||.|.. .| .| | .. .|  .... |  . ||  |. |  |   ..|.  |...| ..   .|   ..| ...         .. |. .  ..|. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKSVPKQTSLFLRYMREVkKTYladdSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLES
|||.  ||..   |  ..   ..|       .|||||||.||.| |.|.   ..  ..    ..   |. .|.||   ||...| ..|   |  .
wpdhGapkeaytaldilkfc.esy....kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_PTPN13_pd Subfamily PTPN13 429-582 3.3e-20 67.5 In-house 14-162 (273) alignment 
Range on Protein: 429-582
Range on HMM: 14-162/273.0
DQEFKTLSKISPDpspLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSnepfgdYINASFVKSMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTT
..|||.| .. |    .  ..| |.| |.|||   |||... | .|..  .      |||||..|   ..    ||..| |||||| .|| .|.. | . 
aeefkelrelkpl...dtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

IVMLNQL-DKTDSTTGQYWPDGGS--V-QYGPFTISTTSVEKNIGMIVRTLQVQLTET
|.|. .  .|      .|||.  .  .  .. ....   |.|  |. ||.|.|. .|.
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 452-578 5.1e-19 63.3 In-house 17-146 (270) alignment 
Range on Protein: 452-578
Range on HMM: 17-146/270.0
KAECKKKNRDSSVLPIERNRAILQSWYSnEPFGDYINASFVKSMGNDSSPyYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDK-TDSTTGQYWPDGG
 |  || ||   .||  . | .|..  . ..   |||| .|. . ...   || .. ||| |. .|| .... | |.|||. .|     .   .|||   
aargkklnRyadiLPsPatRvrleelee.dsataYinAnyvrGfdgekkk.YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

----SVQYGPFTISTTSVEKNIGMIVRTLQVQ
    ....|  .. ..| ||. | |.. |...
kekvkledgkikvlalseekeegyiltrlrle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 428-580 6.7e-19 62.7 In-house 12-162 (287) alignment 
Range on Protein: 428-580
Range on HMM: 12-162/287.0
LDQEFKTLSKISpDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSwySNEPFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPT
.|.|...| . | . |..  ..  .    |||| . ||||. .| .|      |   ||||| .| |  .| .  .|..| |.. || .|| .|.. . .
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsa..egelGsdyinanyvasytddea..fiaaqgPiaatvrdfwravletrsa

TIVML-NQLDKTDSTTGQYWPDGG-SVQYGPFTISTTSVE-KNIGMIVRTLQVQLT
.....  .....   . .|||.    .. | ...   . . |.    ||.|..   
svitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidl
subfamily_PTPN9_pd Subfamily PTPN9 454-582 8.9e-19 62.6 In-house 41-169 (297) alignment 
Range on Protein: 454-582
Range on HMM: 41-169/297.0
ECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-DKTDSTTGQYWP--DGG
   .||| . || ... |  |..  ....  |||||.||   |      .| || ||..|| .|| .|.. .  .|||  .. ..     |||||  .. 
anleknrytdvlcydetrvvlakv.dedeasdyinanfvd..GykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

SVQYGPFTISTTSVEKNIGMIVRTLQVQLTET
| ..| ...|. .||..    ||.|... ..|
saefgdlsvsnveveeeedykvrvleiknvkt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 502-580 1.9e-18 61.1 In-house 237-314 (440) alignment 
Range on Protein: 502-580
Range on HMM: 237-314/440.0
YYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDktDSTTGQYWP-DGGSVQYGPFTISTTSVEKNIGMIVRTLQVQLT
 .| |||||  ||..|| ||.||. .||.|||||.  | |   ||| .  || .||||.     |.   . ||||...  
afiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk
subfamily_PTPN1_pd Subfamily PTPN1 438-581 2.7e-18 60.7 In-house 15-157 (290) alignment 
Range on Protein: 438-581
Range on HMM: 15-157/290.0
ISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSnepfgDYINASFVKSmgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-D
|. . | . .|.  . | ...||   | | .  | .|..        ||||||.|.   ..    ||.|| |||.||  || .|.. |  ..||||.. .
irkeasdfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslvel..eeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

KTDSTTGQYWPDGGS---VQYG--PFTISTTSVEKNIGMIVRTLQVQLTE
|      |||| | .   ...    ...   | |..   .||.|...  .
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 413-569 1.4e-17 58.3 In-house 7-152 (439) alignment 
Range on Protein: 413-569
Range on HMM: 7-152/439.0
LQELTKQDPKGGQTLLDQEFKTLSKISPDPSPLAIRTGsKAECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMGNDSspYYIVTQMPLPE
.||  ..  |  | .....|.... .||| .  |  .  .   . |||  .| . .  | .||      |   |||| ..|   .|    || ||.|  |
fqehvekldknkqeifkeifekinstspdyaciaslaa.qeydqtknrykdvgafdhtrvtlqei.pgvphshyinanyikGyyddk..lyiatqgpkke

TVVNFWSLVYDYKPTTIVMLNQLDKTDSttgqYWPDGGSVQYGPFTISttsVEKNIG
|. .|| ||.. | .||||| .| ..      |||  . | ||  ..    |..|| 
ttddfwrlviekktvtivmltnlvesyk....ywpsdaevcygdiavr...vdrnie
subfamily_hpo-7_pd Subfamily hpo-7 217-419 5.7e-17 56.5 In-house 45-246 (263) alignment 
Range on Protein: 217-419
Range on HMM: 45-246/263.0
NTVDDFWRMIWQEKIRVVSMVTKLEEVLKTKCECYWPDSgADETYGEIHVEAKSTEERDFGVLREFIIFKASEDKRK---LTHFQFTKWPDKSVPKQTSL
.|.| |...| | |  || |..  .|  . ||. |.|    ||     .|.  .|.  .  .|.   . .  ..|.|   ..|.... |..|  |...  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPle.kdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

FLRYMRevkktyLADDSAPLLVHCSAGIGRSGVLIAMDSVVE------QAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLEsLVCDDtrIPVD
 |. ..      .| .| .| ||||.|||||     ...|        .   |....   ... .|. |.  ..|  |  |    ||. .| ..   . .
ilnilk......varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd.fvlnn..fakg

GFEVRLQELTKQ
  | . ||. | 
eleakyqeirks
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 453-571 8.4e-17 55.9 In-house 45-172 (350) alignment 
Range on Protein: 453-571
Range on HMM: 45-172/350.0
AECKKKNRDSSVLPIERNRAILQ-SWYS------NEPFGDYINASFVKSM--G-NDSSPY-YIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-
 |   ||| . .|| |..| .|. |  |           |||||...|    . .  . . || || |||.|| .|. ...  | . |..|....  .  
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

TTGQYWPDGGsvqYGPFTISTTSVEKNIGMI
   .||..|.   |  .|.  .|  .||. |
kcyrYWqegs...ydditvklaskwenimgi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 119-197 8.5e-16 52.3 In-house 6-84 (440) alignment 
Range on Protein: 119-197
Range on HMM: 6-84/440.0
ISLDEFTKYVHTNRQSLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDPYSDYINASYID
| . .|. ||. ||.|    .|.  ||   ..    | | .|| |||||||| |..|||.|| .   | |||||||||.
iivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 330-397 1.9e-15 51.5 In-house 228-295 (297) alignment 
Range on Protein: 330-397
Range on HMM: 228-295/297.0
SAPLLVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
.|.||||||||.|||||..  | .... ..    .|  ... .|| |  .||| ||. .|..|||. |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 454-580 2.2e-15 51.5 In-house 2-126 (237) alignment 
Range on Protein: 454-580
Range on HMM: 2-126/237.0
ECKKKNRDSSVLPIERNRAILQSWYSNepfGDYINASFVKSMGNdSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-DKTDSTTGQYWPDGG-S
| | ||| ...   . .| .|.   |.    |||||...|..   .   || .| ||  .  .|| .|.. | . ||||  | .. .    .|||.    
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdg.tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

VQYGPFTISTTSVEKNIGMIVRTLQVQLT
  || .|.| .  |.     ||.| ..  
aaygvltvslkkkeefsdytvrslllskr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 428-566 5.6e-15 50.1 In-house 8-136 (267) alignment 
Range on Protein: 428-566
Range on HMM: 8-136/267.0
LDQEFKTLSKISPDPSPLAIRTGSKAEckKKNRDSSVLPIERNRAILQSWYSNepfgdYINASFVKSMgnDSSPYYIVTQMPLPETVVNFWSLVYDYKPT
...||. . |||.. | ..   ..| .  ..||   .|| . .| ||.    .     |||||.|..        .|||| ||  |. .|. .. |.| .
iekefelikkisdtsstisqsiaeknq..ernrlddnlpyddtrvilrtkeee.....yinasyvegy..ktknafivtqdplkntitdfltvihdqkvp

TIVMLNQLdKTDSTTGQYWPD-GGSVQYGPFTISTtSVEK
.||.| .   ||     . |  | . .|  .|.   |.||
vivlltkv.ftdnirlfwPPkmgqakkyqdltveh.slek
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 138-399 6.6e-15 49.5 In-house 25-285 (303) alignment 
Range on Protein: 138-399
Range on HMM: 25-285/303.0
IEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEvidDdpySDYINASYIDVNPDHKFVLPTIshkgPKKNTVDDFWRMIWQEKIRVVSMV
..||| . .    .|.  .. .|  |||. ...  . |.| |    |   | || |||.... ..| .|  .    |   |  |||.|| ..|...| ..
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls...d...ssyihasyleldsskkailtql....plshtaadfwqmiieqkvkcvlll

TKLEEVLKTKCECYWPDSGADETYGEIHV---EAKSTEERDFGVLReFIIFKASEDKRKLTHFQFTKWPDKSVPKQ-TSLFLRYMREVKKTYL-ADDSAP
    |  |   .  .|       . |  .   | |  |  |  ||.  .     . |  |   .. .|| .|.| . .. |.. . ...       || |
ltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlk.vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstp

LLVHCSAGIGRSGVLIAMDSV-VEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVF----LHEAVLESLVC
 .    .| ||.| .  ...  .   .    ...   .. .|. |   ||   |. .    | | ||.  .|
tvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngic
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 289-394 9e-15 49.2 In-house 212-341 (350) alignment 
Range on Protein: 289-394
Range on HMM: 212-341/350.0
EDKRKLTHFQFTKWPDKSVPKQTSLFLRYMR---------EVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVE-------QAKRTGKVN--------
 |   . ..|. .|.| |.  .   .|. .            .. .  . |.|.|||||||.|| |.|...||...         |.  |..        
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

VHGFVQAMRECRQNMVQTDEQYVFLHEAVL
..  |. .|. | .|||. .|..|..||.|
isiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 334-397 2e-14 47.7 In-house 2-65 (69) alignment 
Range on Protein: 334-397
Range on HMM: 2-65/69.0
LVHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
.||||.| ||.| .||.   . . |    |..   || || ||  ||  . .|.|.|.|. |.|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
0049772 (Phosphotyrosine protein) phosphatases II 443-536 2.3e-14 49.3 In-house 34-152 (314) alignment 
Range on Protein: 443-536
Range on HMM: 34-152/314.0
SPLAIRTGSKAECKKKNRDSSVLPIErNRAILqSWYSNEPfGDYINASFVKSMgndssPYYIVTQMPLPETVVNF----------WSLV--YDYKPTTIV
..| | .... . ..|||   .|| . || || . ....   ||||||.|...       .|.|| ||..|||.|          |..|  .|... .||
peltilvadlflnrdknryldilpad.nrvil.pglpvsg.sdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LNQLD
|                     |..||
msrdevladelsrLdaAlgKtpllild
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 454-576 2.5e-14 48.0 In-house 7-127 (239) alignment 
Range on Protein: 454-576
Range on HMM: 7-127/239.0
ECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDK-TDSTTGQYWPDGGSv
  | ||| . ..  ...| .|.   ||.|. ||||||...   . |   || ||  .  .  .|| .... .   ||||  | .       |||||  | 
vnkaknryanivtydhsrvvlek.lsndphsdyinasylrdy.dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

QYGPFTISTTSVEKNIGMIVRTLQ
.|  . ..    |     |.||. 
kycnlrvtlrktevfadyiirtfv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 454-576 2.5e-14 48.0 In-house 6-126 (239) alignment 
Range on Protein: 454-576
Range on HMM: 6-126/239.0
ECKKKNRDSSVLPIERNRAILQSwYSNEPFGDYINASFVKSMgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDK-TDSTTGQYWPDGGSv
  | ||| . ..  ...| .|.   ||.|. ||||||...   . |   || ||  .  .  .|| .... .   ||||  | .       |||||  | 
vnkaknryanivtydhsrvvlek.lsndphsdyinasylrdy.dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

QYGPFTISTTSVEKNIGMIVRTLQ
.|  . ..    |     |.||. 
kycnlrvtlrktevfadyiirtfv
subfamily_eak_pd Subfamily eak 132-322 4.6e-14 46.5 In-house 26-208 (332) alignment 
Range on Protein: 132-322
Range on HMM: 26-208/332.0
RQSLELIEEFEALPGVNTEQVTyAKLeENKPKNrYRNILPYNNSRVVLEVIDDDPySDYINASYIDVNP-DHKFVLPTIshkgPKKNTVDDFWRMIWQEK
 | ........    . ....| |.| |.  .|   .|.||.   | |     ..   ||||| .. .   .|..|  |    .... |  ||.|. ..|
nqrinivadlddyqrllsiset.arl.eavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGi....asedkvfafwqmvleqk

IR-VVSMVTKLEEVLKtKCECYWPDSGADE-TYGEIHVEAKSTEERDFGVLREFIIFKASEDKrKLTHFQFTKWPDKSVPKQTSlFLRYMREVK
   .| .. ..|. |. | . |.|| . .|  .| ..|| |.  .|.    | ... |  | . .. |...  | . ..||    || . . .|
spaivqlledvelkle.ksdkyfpdktreelkfGildverkefvkrniletrllelskGneth.rvlhykvfGwtettlpkyed.flalrkvmk
0041856 (Phosphotyrosine protein) phosphatases II 456-551 6.4e-14 47.4 In-house 2-76 (182) alignment 
Range on Protein: 456-551
Range on HMM: 2-76/182.0
KKKNRDSSVLPIERNRailqswysnepFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNqldktdstTGQYWPDGGS
..||| | .||....|           . |||||... .   ..   .|.|| ||..|| .|. ...... ||||.|.          .|||.   
ldknrysdilpydhsr...........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt........eelywpelle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 335-397 1.1e-13 45.4 In-house 2-64 (69) alignment 
Range on Protein: 335-397
Range on HMM: 2-64/69.0
VHCSAGIGRSGVLIAMDSVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQYVFLHEAVLESL
||||.| ||.| .||.   . . |    |..   || || ||  ||  ...|.|.|.|. |.|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 393-554 1.1e-13 45.4 In-house 35-186 (244) alignment 
Range on Protein: 393-554
Range on HMM: 35-186/244.0
VLESLVCDDTRIPVDGFEVRLQELTKqDPKGGQTLLDQEFKTLSK--ISPDPSplAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNepfGDYINAS
|| . .. .  | .  |.     |.    | |   .. ..   |.  | ||||   ..   . .   |||... ||.. ||  |           |||||
vlsanatknryinilpfdetrvilss.skkegsdyinanyiqgsqniirpdps..vmkdafnpnnswknregaglpfdfnrvplskgsmg...ntyinas

FVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDsttgQYWPDGGSVQY
||  .|  .   ||.|| || .| ..|| .. . .   .|.|  ... |    .||||   ...
fvgclgrtae..yiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplew
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 160-274 1.3e-13 45.1 In-house 48-171 (349) alignment 
Range on Protein: 160-274
Range on HMM: 48-171/349.0
NKPKNRYRNILPYNNSRVVLEVIDDD--------------PYSDYINASYID---VNPDHKFvlptISHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEE
   ||||..||||. |||.|.                      ||||| |.    .....|.    |... |   |||||...|  .....|  ... .|
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekky....iatqaPlPstvddfykvillngvklvlsLnddke

VLKTKCECYWPDSgadeTYGEIHVEAKSTEER
    ||. || .     .| .|.|  . . . 
lslekcdiywqel....sysnitvklqnssly
subfamily_CG42327_pd Subfamily CG42327 453-549 1.8e-13 44.8 In-house 26-121 (319) alignment 
Range on Protein: 453-549
Range on HMM: 26-121/319.0
AECKKKNRDSSVLPIERNRAILQSWySNEPFGDYINASFVKSMgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPDG
. .|.|.|   |.|.   |..||.  ....   |..||.|.   .|.  .|| .|..| ..  .|| .|.. .  .|| | .| .       .|.|  
vtskdksrvinvvPlPetrvvlqri.gdddkdeyldasyvrGy.ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 457-581 2.5e-13 44.6 In-house 37-160 (285) alignment 
Range on Protein: 457-581
Range on HMM: 37-160/285.0
KKNRDSSVLPIERNRAILQSWYSnepfgDYINASFVKSMGNDSSPyYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPD--GGSVQ
  || . |  ||  | .|.         ||| ||...  |.| |  || || |||||. .|| ..|. | . ..||  | .        |.|.  |  |.
dlnryadvrcieetrvvlknhdr.....dyihaswmrmpgkdqst.yittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGPFTISTTSVEK--NIGMIVRTLQVQLTE
.| . |. | ...    | |. .| |  ||
fgkyeitlteckeeaiagtilnaltvinte
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 454-578 2.6e-13 44.3 In-house 55-175 (290) alignment 
Range on Protein: 454-578
Range on HMM: 55-175/290.0
ECKKKNRDSSVLPIERNRAILQSWYSnepfGDYINASFVKSMgndsSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-DKTDSTTGQYWPD--GG
   ||||   |   .. | ||.  |     |||. | .|| .     . .|.|| .| .||...| .| . | ..|||| .| ..  .   ||.|.  | 
tefkknrykdvvcndktrvilkdGyd....GdyvhanyvkGl....kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

SVQYGPFTISTT-SVEKNIGMIVRTLQVQ
 . .| .|.  . . .|.  .| .|| |.
vltfGeitvlcseeddkdaniikktlsvr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 454-549 5.2e-13 43.5 In-house 32-125 (297) alignment 
Range on Protein: 454-549
Range on HMM: 32-125/297.0
ECKKKNRDSSVLPIERNRAILQSWYSNepfGDYINASFVKSMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKT-DSTTGQYWPDG
 . .|||   .|  . .|  |.   ..    ||||| .|    ...  .||..| || .|| .|| ||..    .|||. .| .   .    |||. 
sslrknryrdilatddtrvkllrvite...rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv
subfamily_ptpA1_pd Subfamily ptpA1 444-549 6.1e-13 43.3 In-house 36-138 (418) alignment 
Range on Protein: 444-549
Range on HMM: 36-138/418.0
PLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPfGDYINASFVKSMgndSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQL-DKTDSTT
|     | |     ||| . .||... |  |.    .|   ||||| ..          .|.|| |||.|. .|| .|.. .   ||||..  ..     
psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg.sdyinanyidga...ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikc

GQYWPDG
 .|||. 
drywpeq
subfamily_CG42327_pd Subfamily CG42327 329-392 2.4e-11 37.9 In-house 246-310 (319) alignment 
Range on Protein: 329-392
Range on HMM: 246-310/319.0
DSAPLLVHCSAGIGRSGVLIAMDSVVEQAKRT-GKVNVHGFVQAMRECRQNMVQTDEQYVFLHEA
.  || |||| |.||.|..|| |  ... . .   |..   |. .|. | . |.| ||| |..  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
0051429 (Phosphotyrosine protein) phosphatases II 482-579 2.8e-11 39.1 In-house 2-112 (272) alignment 
Range on Protein: 482-579
Range on HMM: 2-112/272.0
PFGDYINASFVKSMGNDSSPY-YIVTQMPLPETVVNFWSLvYDYKPTTIVMLNQLDKTDSTT-GQYWP------------DGGSVQYGPFTISTTSVEKN
|...||||..|. .|.   |  .. ...||| |. .|| | .... .|||.| ...  ..    .|||            .  .. || ... ..|.|  
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

IGMIVRTLQVQL
  .|.|.|.. |
ldyilrellltl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 430-549 2.9e-11 37.6 In-house 12-130 (281) alignment 
Range on Protein: 430-549
Range on HMM: 12-130/281.0
QEFKTLSKISPDPSPLAIRTGSKAECKKKNRDSSVLPIERNRAILQSWYSNEPFGDYINASFVKSMGNDSSpyYIVTQMPLPETVVNFWSLVYDYKPTTI
.  . .|..  ||      .  .   .|||| . .  ..  |  |.    |.   ||| | ...|        ||.|| |  ||  .|| .... . |.|
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg..yiltqgpkketradfwrmiwqenttai

VMLNQLDKTDST-TGQYWPDG
||| |. .|.     .|.|  
vmlcqfletnrekcaeyfprn
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 128-198 2e-10 34.7 In-house 17-83 (95) alignment 
Range on Protein: 128-198
Range on HMM: 17-83/95.0
VHTNRQsLELIEEFEALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDdpySDYINASYIDV
.|.| .  |. .|| ...       |    | | ||||. ||.||. .||||    |   |||||| ..| 
mhsnsd.qefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-558 2.9e-10 34.2 In-house 53-153 (310) alignment 
Range on Protein: 456-558
Range on HMM: 53-153/310.0
KKKNRDSSVLPIERNRAILQSWYSNepFGDYINASFVKSmgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDSTT-GQYWPDGGSV-Q
 .||| | |.  .  |  |.   |   ..||| | .||.  |     .|..| ||  |...|| .... .  .|..| .  .        |||  |    
mhknrysdvvcldtsrvklkidksr..yedyihanyvkt..nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGPFT
||   
ygcir
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 457-537 3.4e-10 34.0 In-house 39-121 (347) alignment 
Range on Protein: 457-537
Range on HMM: 39-121/347.0
KKNRDSSVLPIERNRAILQSWYS----NEPFGDYINASFVKSmgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDK
.|||   |  |.  | .|    |     ..   ||||| .|   ...|  ||.|| |||.|| .|| .|.  | | .| . .  |
sknrskdvklidatrvvlspeksknsraddvetyinashikf..dnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik
subfamily_eak_pd Subfamily eak 435-578 3.5e-10 33.8 In-house 32-173 (332) alignment 
Range on Protein: 435-578
Range on HMM: 32-173/332.0
LSKISPDPSPLAIRTGSKAECKKKNrDSSVLPIERNRAILQSWYSNEpFGdYINASFVKSmgNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVML-N
....      |.|. ... |  ..|    ..| .|.   | |   |.  | ||||| ..   ..    ||.| ..  . |  || .|.. |  .||.| .
vadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnr.lG.yinaslaef..sevGrkyiltGiasedkvfafwqmvleqkspaivqlle

QLDKTDSTTGQYWPDGG--SVQYGPFTISTTSVEKNIGMIVRTLQVQ
....      .|.|| .   ...| . . . .  |.  . .| |...
dvelkleksdkyfpdktreelkfGildverkefvkrniletrllels
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 322-395 5.3e-10 33.1 In-house 257-342 (349) alignment 
Range on Protein: 322-395
Range on HMM: 257-342/349.0
KKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVE----QAKRTGKVNVH--------GFVQAMRECRQNMVQTDEQYVFLHEAVLE
.. . .|....|||||||| ||.|||. .|....      .   |....          |  .|  | .|||   |.....||.|.
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 422-553 7.4e-10 33.3 In-house 13-137 (307) alignment 
Range on Protein: 422-553
Range on HMM: 13-137/307.0
KGGQTLLDqEFKTLSKISPDPSPlairTGSKAECKKKNRDSSVLPIERNRAILQSwysNEPFGDYINASFVKSMGNDSspYYIVTQMPLPETVVNFWSLV
|| |.| | ||. |.| .|.  .    . .     .||| . |  ....| ...    .    ||| | ..    .     .|..| || .|. .||...
kgvqalvd.efrvlakktpegvt....veafsantdknryqdvkcqdkgrivvkf...dglasdyihanylgiaikpk..kficaqgplentqysfwama

YDYKPTTIVMLNQ-LDKTDSTTGQYWPD--GGSVQ
 . |  ...|| . .. .     ||||   |    
iqekvesvimlckvielakikceqywpleegqklv
subfamily_egg_pd Subfamily egg 447-567 1e-09 32.5 In-house 32-152 (307) alignment 
Range on Protein: 447-567
Range on HMM: 32-152/307.0
IRTGSKAECKKKNRDSSVLPIERNRAILQsWYSNEPFGDYINASFVKsmGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTdSTTGQYW
..|  ... ..| |.  |   .  |  |.        .|.| |  ||  |.     .|..| || .|| .|| .|.  .   ||||.   ..      ||
lttaasdnnlekarskrvhckdssrvkle.lrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyyw

PDGG--SVQY--GPFTISTTSVEKN
|     |...  | . | .  |...
pkaesdslvtvpGslrienlkvdsk
0043147 (Phosphotyrosine protein) phosphatases II 481-549 3.6e-09 32.1 In-house 2-76 (172) alignment 
Range on Protein: 481-549
Range on HMM: 2-76/172.0
EPFGDYINASFVKSMGndSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLdktDSTTGQY-----------WPDG
... ||||||... .     . .|.|| ||..|.  || ...... |.||.|..|     .. ..           |||.
degsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel...lydpellerlgiqylylpwpDh
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 451-546 1.7e-08 28.5 In-house 44-134 (305) alignment 
Range on Protein: 451-546
Range on HMM: 44-134/305.0
SKAECKKKNRDSSVLPIERNRAILQSWYSNepfgDYINASFVKSMGNDSspYYIVTQMPLPETVVNFWSLVYDYKPTTIVML-NQLDKTDSTTGQYW
 .|. ..|||   |  ...||  |.. .      .|| | .| .  |     .| || || .|  .|| . .. |  .| || | |.|      .|.
keaqeagknrykdvgcldnnrvklegpwph....eyihanyvstptnpk..rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyf
0038934 (Phosphotyrosine protein) phosphatases II 301-390 1.8e-08 29.8 In-house 84-170 (194) alignment 
Range on Protein: 301-390
Range on HMM: 84-170/194.0
K--WPDKSVPKQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVeqakrTGKVNVHGFVQAMRECRQNMVQTDEQYVFLH
|  .||. .. .... ||... |.. . .| .   .||| ||.||.|.|.|   .      . . ...  .. .||.|...... ...  |.
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.....rlgmsaeeAialfrekRpgaipnqdyleall
0046846 (Phosphotyrosine protein) phosphatases II 482-550 1.9e-08 29.8 In-house 10-77 (176) alignment 
Range on Protein: 482-550
Range on HMM: 10-77/176.0
PFGDYINASFVKSmgndssPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDSTT-GQYWPD----GG
.. |||||... .      ...|.|| |||.|. .|. ...... |..|.|...  ...    .|||.    | 
ldldyinanlilg......srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 142-241 2.9e-08 27.6 In-house 19-118 (347) alignment 
Range on Protein: 142-241
Range on HMM: 19-118/347.0
EALPGVNTEQVTYAKLEENKPKNRYRNILPYNNSRVVLE-----VIDDDPYSDYINASYIDVNP-DHKFVLptisHKGPKKNTVDDFWRMIWQEKirVVS
| | .    ..|... | .  ||| ..    ...||||          |.   |||||.|  .  .....|     . |  .|| |||.|.   |  |  
enlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyil....tqyplpdtvrdfwkmvsvtk..vtq

MVTKLE
.|| .|
vvtife
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 487-578 2.9e-08 27.8 In-house 78-172 (301) alignment 
Range on Protein: 487-578
Range on HMM: 78-172/301.0
INASFVKSMGNDSspYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQ-LDKTDSTTGQYWPD--GGSVQYGPFTISTTSVEKNIG--MIVRTLQVQ
| | .... |.     .|.|| ||..|  .|| ..  |.  .|||| | ..|. . . .| |   . ... | |.| ... |. .   .. |||.|.
ihanwiptsGhph..rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 427-548 6.4e-08 26.6 In-house 25-144 (305) alignment 
Range on Protein: 427-548
Range on HMM: 25-144/305.0
LLDQEFKTLSKI-SPDPSPLAIRTGSKAEC-KKKNRDSSVlPIERNRAILQSwysNEPFGDYINASFVKSMGNdSSPYYIVTQMPLPETVVNFWSLVYDY
 | .||. |.|   || .  |. .   |.  . ||| . | | . . |.. .   . .  ||| | .|          .|..| || .|. .|| .| . 
klreefrglakytrpdmtqvafnanqsadiaitknryqdv.pcqdqsavkld...kpspsdyihanyvgcpmi.pekrficaqgpldqtidefwwmviqn

KPTTIVMLNQ-LDKTDSTTGQYWPD
|   |||| . ..       |||| 
kveqivmlcktvelgklkcaqywpa
0036282 (Phosphotyrosine protein) phosphatases II 485-548 1.1e-07 27.2 In-house 3-60 (174) alignment 
Range on Protein: 485-548
Range on HMM: 3-60/174.0
DYINASFVKsmGNDSSPYYIVTQMPLPetvvnFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPD
||||||...  ..  .|..|..| ||.     || ...... ||.|||...   .     .|||.
dyinaspld..lsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 502-571 1.7e-07 25.6 In-house 6-78 (199) alignment 
Range on Protein: 502-571
Range on HMM: 6-78/199.0
YYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-TTGQYWPD--GGSVQYGPFTISTTSVEKNIGMI
 ||.|| || ||. .|| .|..     |||.|. .|        |||    |. .|| ....| ..  .  . 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdyt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 502-571 1.7e-07 25.6 In-house 5-77 (198) alignment 
Range on Protein: 502-571
Range on HMM: 5-77/198.0
YYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDS-TTGQYWPD--GGSVQYGPFTISTTSVEKNIGMI
 ||.|| || ||. .|| .|..     |||.|. .|        |||    |. .|| ....| ..  .  . 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdyt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 140-198 2e-07 24.9 In-house 18-76 (244) alignment 
Range on Protein: 140-198
Range on HMM: 18-76/244.0
EFEALPGVNTEQ-VTYAKLEENKPKNRYRNILPYNNSRVVLEVIDDDpYSDYINASYIDV
|| .|     |   | | |  |  |||| ||||....||.|     .  ||||||.||. 
efvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 485-566 2.2e-07 25.2 In-house 14-89 (130) alignment 
Range on Protein: 485-566
Range on HMM: 14-89/130.0
DYINASFVKSMGNdsSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDsttgQYWPDGGSVQYGPFTISTTSVEK
.|||||||  .|.  .  |. || || .| ..|| .. .     .|.|  ... |    .||||   ...    |  |. ..
tyinasfvGllgr..taeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 483-549 3.4e-07 23.9 In-house 89-156 (349) alignment 
Range on Protein: 483-549
Range on HMM: 89-156/349.0
FGDYINASFVKSMGNDSSPYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDSTT-GQYWPDG
  ||||| ..|    .    || ||.||| || .|. ..   .   .. ||. ....     .|| ..
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 170-305 4.4e-07 24.3 In-house 3-124 (130) alignment 
Range on Protein: 170-305
Range on HMM: 3-124/130.0
LPYNNSRVVlevidddpYSDYINASYIDVNPDHKFVLPTishKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEvlktkCECYWPDSGADETYgEIHVEAK
|... ||.           .|||||.. .    .  | |   . |  .|  |||.|. .  . |. ..  .||      . |||||   | | | ..   
lefevsrlq........gntyinasfvGllgrtaeyllt...qhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewy.eediivt

STEERDFGVLREFIIFKASED---KRKLTHFQFTKWPDK
.|.  .|  ..   .   |.    .. || || ..||  
ltdrdefknikasnleiesdlneshqaltmfqisnwpsd
0051082 (Phosphotyrosine protein) phosphatases II 482-550 5e-07 25.0 In-house 1-57 (151) alignment 
Range on Protein: 482-550
Range on HMM: 1-57/151.0
PFGDYINASFVKSMgndsspyYIVTQMPLPetvvNFWSLVYDYKPTTIVMLNQLDKTDsTTGQYWPDGG
|. ||||.|.| .        ......||.     |. |..... .|||.|.... .. .  .|.|. |
plsdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 467-580 5.5e-07 24.0 In-house 30-153 (290) alignment 
Range on Protein: 467-580
Range on HMM: 30-153/290.0
IERNRAILQSwYSNEPFGDYINASFVKSMGNdssPYYIVTQMPLPET-------VVNFWSLVYDYKPTTIVMLNQLDKTDSTTGQ-----YWPD--GGSV
.| .| .|.  | .    ||| |..|.   .      |.|| |. ..       . .|| .. . | . .||| . .. .. |..     | |.  |...
veatrvvLkg.ygkrfnddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

QYGPFTISTTSVEKNIGMIVRTLQVQLT
... .|.. .| ||. ....|.| |.  
kfkgltvkCkskekeddvetRelvvkfd
subfamily_PTPDC1_pd Subfamily PTPDC1 301-391 5.7e-07 24.1 In-house 89-170 (182) alignment 
Range on Protein: 301-391
Range on HMM: 89-170/182.0
KWPDKSVPKQTSLfLrYMreVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDSVVEQakrtgKVNVHGFVQAMRECRQNMVQTDEQYVFLHE
 |.| .|.  ... |  .  ||    | .   . ||| || || |||||   |  .     ... .  .. .|. | . .|| ||  ...|
gwkDygvasleri.L.di..vkvvafalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvke
subfamily_PTEN_pd Subfamily PTEN 291-387 5.9e-07 24.6 In-house 79-172 (184) alignment 
Range on Protein: 291-387
Range on HMM: 79-172/184.0
KRKLTHFQFTkwpDKsVPKQTSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMDsVVEQAKRTGKVNVHGFVQAMRECRQNMVQTDEQ--YV
. ......|.   |.  | . .|. . .....|   .|..    ||| || ||.||||.   .... . . . ..  . ...|   .. |.   |  ||
dgrvavypfd...Dh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqrRYv
PTEN_1 301-350 5.9e-07 24.5 In-house 101-150 (196) alignment 
Range on Protein: 301-350
Range on HMM: 101-150/196.0
KWPDKSVPKQTSLFlRYMREVKKTYLADD-SAPLLVHCSAGIGRSGVLIAM
 ..|  .|   .|| .  ....  .|.|.     |||| ||.||||...|.
pieDhgapslself.dicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa
0044763 (Phosphotyrosine protein) phosphatases II 476-561 6.8e-07 24.6 In-house 10-85 (178) alignment 
Range on Protein: 476-561
Range on HMM: 10-85/178.0
SWYSNEPFGDYINASFVKsmgndssPYYIVTQMPLpetvVNFWSLVYDYKPTTIVMLNQLDKTD-STTGQYWPDGGSVQYGPFTIST
|...... .||||||..        |...... |     .... |..... |.||.|.. .      . .|||.. ..||  . |. 
snleglersdyinaseil.......pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipD
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 149-276 1.4e-06 22.0 In-house 23-145 (332) alignment 
Range on Protein: 149-276
Range on HMM: 23-145/332.0
TEQVTYAKLEENKPKNRYRNILPYNNSRVvlEVIDDDPYSDYINASYIDVNPDHKFVlptISHKGP-KKNTVDDFWRMIWQEKIRVVSMVTKLEEVLKTK
|   || |. .|   ||   .  .. |||  |.  .|   |. |||..|    .      |  . | .  |   ||||. . |  .. ..  ..|  | |
typntydkflnnmdmnriphlycfdhsrv..elapqdgkddfynaswvdgyskksay...ifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

CECYWPDSGADETYGEiHVEAKSTEERDF
.     | | ....    . ||| || ..
apydisdrgfeksflh.efgaksleecel
subfamily_PRL_pd Subfamily PRL 304-389 2.4e-06 21.7 In-house 65-142 (151) alignment 
Range on Protein: 304-389
Range on HMM: 65-142/151.0
DKSVPKQtSLFLRYMREVKKTYLADDSAPLLVHCSAGIGRSGVLIAMdSVVEQAkrtgkVNVHGFVQAMRECRQNMVQTdEQYVFL
| .|| . ..  .... .|...  . .. . ||| ||.||. ||.|. ...|.      .. .  |. .|| |.. . . .|  ||
dGavPpe.evveeWlellkekfkeepkstvavhcvaGlGraPvlval.alieaG.....mkyedavefirekrrgains.kqlkfl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 210-273 2.8e-06 20.9 In-house 240-300 (440) alignment 
Range on Protein: 210-273
Range on HMM: 240-300/440.0
SHKGPKKNTVDDFWRMIWQEKIRVVSMVTKLEEvlKTkCECYWPDSGADETYGEIHVEAKSTEE
. . |   || ||||.. . .|  . |. .|..  || |  |||      |.| . |  | .|.
atqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsvtfgpftvghkgsen
0049260 (Phosphotyrosine protein) phosphatases II 501-549 2.9e-06 22.6 In-house 9-65 (152) alignment 
Range on Protein: 501-549
Range on HMM: 9-65/152.0
PYYIVTQMPLPETVVNFWSLVYDYKPTTIVMLNQLDKTDST-TGQ-------YWPDG
 ..| || |.|.|. .|| ...... ||||||..|.  .   . |       .|||.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDh
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 213-305 3.8e-06 20.7 In-house 144-233 (244) alignment 
Range on Protein: 213-305
Range on HMM: 144-233/244.0
GPKKNTVDDFWRMIWQEKIRVVSMVTKLEEvlktkCECYWPDSGADETYGEiHVEAKSTEERDFGVLRE---FIIFKASEDKRKLTHFQFTKWPDK
 |  .|  |||.|. . .. |. ..  .||      . |||||   | | |  .    |.  .|  ..     |     | .. || || ..||  
hpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdseplewyee.ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsd