Gene PTPN12 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP056_AA protein Get Run
SpurP056_AA_12-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 23-308 1.7e-141 465.3 In-house 3-289 (290) alignment
Range on Protein: 23-308
Range on HMM: 3-289/290.0
SLDGSDSFELEFNHLKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRM
. .|...|. ||..||..|..|..||||.|.|||...|..|||||||||.|.||. ||.|...|||||.||||.||......|.|||||||.|...||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

LWECNTEIIVMACNEFELGRHKCERYWVDEGEEHC-FGDILVTQIGQQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREY
.||.|.||.||||.|.|||..||||||..||||.. ||.. ||.. ...|..||.|||||....||.....|||||||||||||.|.|..|..|.||||.
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

QTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLGIKPEDYG
|..|. |.|||||||.||||||..|||||..|. |||.......|.....||||.|.|||..|||||..||....|..|.|..|...
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieekks

0051299 (Phosphotyrosine protein) phosphatases II 6-295 1e-88 292.8 In-house 6-285 (288) alignment
Range on Protein: 6-295
Range on HMM: 6-285/288.0
NLENFLEHYENMAdlsssLDGSDSFELEFNHLKQISQRyrtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTY
..|..|......      ..|   .. ||..| ..         ...||.    |. ||||.||||.||||  || .|.||||||.||....|  .....
sveellklvlkll.....angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

LAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT------RDKEEKIFNQFHYTAW
.|.|||||.||..||||.|| |...||| ....|||| ||..|| . |.  ..||| || .  .   .|...|||. |       |.|... ..||||.|
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnw

PDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
||||||.|....||...|||... . ..|.|||||||.|||||....|.. . |. |   . .......  .|.||. .||| .||..|..|... 
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_PTPRD_pd Subfamily PTPRD 29-318 1.5e-88 292.8 In-house 24-304 (564) alignment
Range on Protein: 29-318
Range on HMM: 24-304/564.0
SFELEFNHLKQIsqryrteKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNT
.|| |......        .  ...| . ..| .||||..|...||||  ||.....|||||.||.|..|  ....|.|.||||..|...||||.|| |.
kfeeeykkieeg.......qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqns

EIIVMACNEFELGRHKCERYWVDEGeEHCFGDILVTqIGQQRVTKDFMIRTLKA--TRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE
..|||  .  | |..||..|| ..| .  .|.. || . ..   .|..|||.|   ....| .  .|||.|.|||||||.| ...||.|. ||.... ..
stiVmltkleEkgkvkchkYWPekg.tetygeltVt.leeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepda

PPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH-LGIKPEDYGHNYENVQLKH
 ||||||||| ||||| .|||.. . ..    ...  .| ..  .|||| |.|||..||  .|.|.... ..    .. |.. .. .... ..
gPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeve

0050432 (Phosphotyrosine protein) phosphatases II 10-300 1e-87 289.6 In-house 24-303 (308) alignment
Range on Protein: 10-300
Range on HMM: 24-303/308.0
FLEHYENMADLSSSLDGSDSFELEFNHLKQISQryrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLsqidNvEGSDYVNANFLKGA--ANDHTYLA
.  ...... |  .....  .| ||..| ..        ....|...   |. |||||||||.||||  |    . |||||.||.. .|    ......|
lklsvldllkllekaldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIa

AQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE--GEEHCFGDILVTQIGQQRvTKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHG
.|||||.||. ||||.|| |...||| ....| || ||..|| .|  |.  ..|.. || . ..   .|...|||. |   |.|... ..||||.|||||
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhg

VPTSVKPILDMIKLVREYQtaEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
||.|....||...|||...  ...|||||||||.|||||....|.. . |. |   .........  .|.||.  ||| .||....||...... .|
vPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0046845 (Phosphotyrosine protein) phosphatases II 31-300 8.4e-87 286.4 In-house 3-278 (284) alignment
Range on Protein: 31-300
Range on HMM: 3-278/284.0
ELEFNHLKQISQRYRtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNV-EGSDYVNANFLKGA-----ANDHTYLAAQGPLPHTVNEFWRMLW
| || .| ..   .     ...|..    |. |||||||||.||||  |. .|.  |.|||.||....|       . ....|.|||||.||..||||.|
eeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvw

ECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREY
| |...||| ....| || ||..|| .|||   .||. || .  .   .|...|||. |.   ..|... ..||||.|||||||.|....|....||||.
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrel

QT--AEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
..    ..|||||||||.|||||....|.. . |. |... ........  .|.||.  |||  ||..|..|...... .|
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPRB_pd Subfamily PTPRB 6-298 3e-85 280.8 In-house 8-287 (293) alignment
Range on Protein: 6-298
Range on HMM: 8-287/293.0
NLENFLEHYENMADlssslDGSDSFELEFNHLKQISQRYRtekvypTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTY
.||.| ||...|.      |    |  |...||.. .         ..| |. ||  ||||..|||.||||  |..... .||||.|||...|    . .
klekfeehvkkmka.....dsdlrfseeyeelkavgkdqa......vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspref

LAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQrVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVP
.|.|||||.||..||||.|| ...||||  . .| |. |||.|| .. |.. .||| || . .. ...|..||.|| ...|||.  .|.|.|.|||||||
iatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee.eledwvirelkiekekeerkvrqyhftsWpdhgvP

TSVKPILDMIKLVREYQ--TAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
 . |..||... |||..  ||.. ||||||||| |||||   .| . .|..    ..   .. |....|..|  .||| .||  .|..|.|... 
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0040438 (Phosphotyrosine protein) phosphatases II 34-301 3.9e-84 277.9 In-house 17-281 (317) alignment
Range on Protein: 34-301
Range on HMM: 17-281/317.0
FNHLKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVM
|. |..  ..... |....| .|  .|. ||||.||||.||||  || ......|||.||.. .|    ....|.|||||.||. ||||.|| ....|||
ftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

ACNEFELGRHKCERYWVDeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVV
 ....|||| ||..|| . ||.  .||. || .. .   ... .|||. .  .|.|. . ..||||.||||||| | ...||....|||..  .. |..|
LteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlV

HCSAGCGRTGTICVIDYVRNALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLG
|||||.|||||....... . |. |.   ........  .|.||. .||| .||. ...|. .... .| 
HCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt

0047943 (Phosphotyrosine protein) phosphatases II 23-294 1.8e-83 275.5 In-house 7-270 (273) alignment
Range on Protein: 23-294
Range on HMM: 7-270/273.0
SLDGSDSFELEFNHLKQISQryrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLsqidNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRM
.|.|.. ...||..|...        ....|...   |. |||||||||.||||  |    . .||||.||....|    ....|.|||||.||..||||
kllgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

LWECNTEIIVMACNEFELGRHKCERYWVDEGE--EHCFGDILVTQIGQQRvTKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLV
.|| |...||| ....|||| ||..|| .||.  .  .|.. || ....   .|...|||. |.  ..|... ..|||| |||||||.|....|..|.||
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

REYQTA--EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
|... |  ...|.|||||||.|||||....|.. . |. |   .........  .|.||. .||| .||.....|...
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealle

0045450 (Phosphotyrosine protein) phosphatases II 23-294 2.3e-83 275.7 In-house 22-302 (307) alignment
Range on Protein: 23-294
Range on HMM: 22-302/307.0
SLDGSDSFELEFNHLKQISQRYrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNV-EGSDYVNANFL--------KGAANDHTYLAAQGPLP
 ||.   .. ||..|...  ..    ....|.... .|. |||||||||.||.|  || .|.  |.|||.||..         .|  ......|.|||||
lldfltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

HTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVKP
.||..||||||| ....||| ....|||| || .|| ||||| ..|.. || .. .   ... .|||. |    ..|. . ..||||.|||||||.|...
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

ILDMIKLVREYQTA--EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
.||.|..||... .  .. |..||||||.|||||.......   |. |.. ....|....  .|.||. .||. .||. ...|. .
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0036941 (Phosphotyrosine protein) phosphatases II 37-300 4.9e-83 274.1 In-house 22-281 (297) alignment
Range on Protein: 37-300
Range on HMM: 22-281/297.0
LkqisqrYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLsqidNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
|      ..  . ...|....  |. |||||||||.||.|  |    . |||||.||....|   .....|.|||||.||..||||.|| |...||| ..
l......lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte

EFELGRHKCERYWVDE-GEEHCFGDILVTQIGQQRV-TKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA--EEPPIV
..|||| ||..|| .| ||. ..||. || .. . |  .|. .|||. |   ..|... ..|||| |||||||.|....||.|.|||... .  ...|..
lvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvl

VHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
||||||.||.||....|.. . |. ... .........  .|.||. .||| .||. ...|. . .. .|
VHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0039614 (Phosphotyrosine protein) phosphatases II 23-299 5.2e-83 274.2 In-house 27-292 (297) alignment
Range on Protein: 23-299
Range on HMM: 27-292/297.0
SLDGSDSFELEFNHLKQISQryrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNV-EGSDYVNANFLKGAAN-DHTYLAAQGPLPHTVNEFW
 ....  ..||| .|...          ..| ... .|. |||||||||.||||  |. .|.| ..|||.||....|    .....|.|||||.||. ||
kansktllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMLWECNTEIIVMACNEFELGRhKCERYWVDEGEehCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVRE
||.|| ....||| ....|||| ||..|| .||.  ..||. || .. .   .....|||. |...|... ..|.|| ||||||| |.. .|....||||
rmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

YQTA--EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH
.. .  .. |..||||||.|||||....... . |. |   .........  .|.||. .||| .||. ...|...... .
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-298 8.5e-83 273.0 In-house 6-282 (318) alignment
Range on Protein: 9-298
Range on HMM: 6-282/318.0
NFLEHYENMADlssslDGSDSFELEFNHLKQISQryrteKVYPTSAgESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAA
.. .| ...       .|.  .. |...|.. ..     .|  . .  ..|| .|||| .||..||.| .|......|||||.|||.. |  ....|.||
dleshvrrlre.....sGelllseeyerlsrsee.....tvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEhCFGDILVTQIGQqRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPT
|.|||.|...||||.|| |. .|||  .| | |..|..||| ..| .  .|.. |.   .   ..|...|..| ||..  |...  |.|||.|||.|||.
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkee.velsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpe

SVKPILDMIKLVREYQ-TAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
|.  .||... |...| .... ||||||||| ||||. ...| . . .. |..     .....  .|.|| ..|||..|||... ..... ..
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvllealas

DSPc_SM00195 35-296 3.2e-82 271.1 In-house 7-262 (263) alignment
Range on Protein: 35-296
Range on HMM: 7-262/263.0
NHLKQISQRYrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMA
..|..  .        .|. .| . |..|||||.|||.||.|  |..... |||||.|||..||| ....| |.|||||.||..|||| || ...|||| 
ekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CNEFELGRHKCERYWVDE-GEEHCFGDILVTQIGQQRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVV
..|.| |. ||.||| .| |..  ||.| |. . .. . ... .|||. | ..  |.. ..|..|..||||||| | |..|.... |.. .  ...||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
|||||.|||||...||.. . |. ||    ... .|.  .||||. .|||..||  ...|.....
hCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 35-296 3.2e-82 271.1 In-house 7-262 (263) alignment
Range on Protein: 35-296
Range on HMM: 7-262/263.0
NHLKQISQRYrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMA
..|..  .        .|. .| . |..|||||.|||.||.|  |..... |||||.|||..||| ....| |.|||||.||..|||| || ...|||| 
ekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CNEFELGRHKCERYWVDE-GEEHCFGDILVTQIGQQRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVV
..|.| |. ||.||| .| |..  ||.| |. . .. . ... .|||. | ..  |.. ..|..|..||||||| | |..|.... |.. .  ...||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
|||||.|||||...||.. . |. ||    ... .|.  .||||. .|||..||  ...|.....
hCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0043336 (Phosphotyrosine protein) phosphatases II 37-293 1.7e-81 269.0 In-house 22-274 (278) alignment
Range on Protein: 37-293
Range on HMM: 22-274/278.0
LKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
|..  ..... |....| ...  |. |||||||||.||||  || ......|||.||....|    ....|.|||||.||. ||||.|| ....||| ..
lllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

EFELGRHKCERYWVdeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCS
..|||| || .||   |.  ..||. || ....   .|...|||. |  .|.|... ...||..|||||||.|....||..| |||..  .. |..||||
lvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCs

AGCGRTGTICVIDYVRNALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
||.|||||....... . |. |.   ...|.... ..|.||. .||| .||. ...|. 
aGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyeall

subfamily_PTPN6_pd Subfamily PTPN6 25-296 6.5e-79 260.1 In-house 23-297 (306) alignment
Range on Protein: 25-296
Range on HMM: 23-297/306.0
DGSDSFELEFNHLKQISqryrTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSqIDNVEGSDYVNANFLKGAAN--DHTYLAAQGPLPHTVNEFWRM
 .   || ||..|.|      ..|..  . |.   |..||||| ||||||.|  |.  ..| ||||.|||..|....  |..|.|.|| |..||..||||
lekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

LWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQqRVTKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVR
.|. |...|||. .| | |..|| ||| || |.. .|.| ||.. . . ..|...|.|. .   ..|||.   |.|...|||||||.. . .||... |.
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

EYQTAE----EPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
. |       . ||||||||| |||||. ||| . . .. ...| .. .....  .|.||  .||| .|| .|..|.    
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 24-297 4e-76 250.8 In-house 17-280 (288) alignment
Range on Protein: 24-297
Range on HMM: 17-280/288.0
LDGSDSFELEFNHLkqisqrYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRML
 .. . |. |.| |         ||   ..||.  || .||||..|||.|. |  | . ....|.||.||....|  ....|.|.||||..|||.||.. 
arnrtgfseeynsL......aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT
.| .|. |||  .  | |..|||.|| |..... .|.. || ....  ..||. |.|   ..|.|   .|..|.|||||||| | .|.|.... |   ..
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveske.ledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

AEEPPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|.  ||.|||||| |||||  ..| . .|..    ..   . ...  .||||  .||| .||| ........ .
adtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie

0040439 (Phosphotyrosine protein) phosphatases II 51-294 6.8e-76 250.4 In-house 2-244 (249) alignment
Range on Protein: 51-294
Range on HMM: 2-244/249.0
PTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV
..| ..  .|. ||||.||||.||||  || ......|||.||....|    ....|.|||||.||. ||||||| . ..|||.....|||| ||..|| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA--EEPPIVVHCSAGCGRTGTICVI
. |..  .||. || .  .   .|...|||. |   |.|.   ....|| ||||||| |....||.|..||.....  .. |..||||||.|||||....
l.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
... . |. |   ....|.... ..|.||. .||. .||. ...|. .
ylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyealle

Y_phosphatase Protein-tyrosine phosphatase 60-293 1e-75 249.5 Pfam-A 1-234 (235) alignment
Range on Protein: 60-293
Range on HMM: 1-234/235.0
NMRKNRYKDILPFDHSRYLLsqiDNVEG-SDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHC
|..|||||||||.|..|  |   .. || |||.|||..||  ......|.||||..|...||||.|. ....||| ... | || ||..||  .|.|.  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVTQI-GQQRVTKDFMIRTLKATRDKEEK---IFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAL
.||| |.    ... .|....|.|. . .|||.   ...|.|||.|||||||.|.|..||.|. |.....|.. |.|||||||.|||||....|.. . |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
. |.    .....|.  .||||. .||. .||. ...|..
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 60-293 1e-75 249.5 In-house 1-234 (235) alignment
Range on Protein: 60-293
Range on HMM: 1-234/235.0
NMRKNRYKDILPFDHSRYLLsqiDNVEG-SDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHC
|..|||||||||.|..|  |   .. || |||.|||..||  ......|.||||..|...||||.|. ....||| ... | || ||..||  .|.|.  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVTQI-GQQRVTKDFMIRTLKATRDKEEK---IFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAL
.||| |.    ... .|....|.|. . .|||.   ...|.|||.|||||||.|.|..||.|. |.....|.. |.|||||||.|||||....|.. . |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
. |.    .....|.  .||||. .||. .||. ...|..
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

0042113 (Phosphotyrosine protein) phosphatases II 55-294 3.3e-74 244.6 In-house 4-241 (245) alignment
Range on Protein: 55-294
Range on HMM: 4-241/245.0
GESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDeGE
..  .|. ||||.||||.||.|  || ... ..|||.||.. .|    ....|.|||||.||. ||||||| . ..||| ..|.||||.||..|| . ||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

EHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT-AEEPPIVVHCSAGCGRTGTICVIDYVRN
.  .||. || .. .   .|...|||. |  .|.|..  ...||. |||||||.... .||....||...   .. |..||||||.|||||....... .
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

ALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
 |. |   ...||.... ..|.||. .||| .||. ...|. .
qleke...lgvsleeavkelrsqRpgavqtpsqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 57-297 1.3e-73 243.1 In-house 30-273 (278) alignment
Range on Protein: 57-297
Range on HMM: 30-273/278.0
SDVNMRKNRYKDILPFDHSRYLlsqidnvegsDYVNANFLKGAanDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDeGEEH
   |. |||||||||.||||            ||.||....|   .....|.|||||.||. ||||||| ....|||.....|||| ||..|| . |.  
ylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsl

CFGDILVTQIGQQRVtKDFMIRTLKAT------RDKEEKIFNQFHYTAWPDHGVPTSV--KPILDMIKLVREYQTA-------------EEPPIVVHCSA
 .||. || .  ... .|. .|||. |       | |.  ....||. |||||||..   |..|.... .||.. .             .. |..|||||
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GCGRTGTICVIDYVRNALqlekiDQNFSLYDIIVDMRKQRHA-IVQTRNQYELVHRAVVDMFQ
|.|||||........  |     .....|....  .|.||.  .||. .||. ..........
GvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 30-299 4.7e-73 240.7 In-house 17-279 (281) alignment
Range on Protein: 30-299
Range on HMM: 17-279/281.0
FELEFNHLKQISQRyrtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
|  |...|..| ..       ...| ..| |. ||||..|  .|..|  ... .. . .||.||||..|  ... |.|.|||.|.....||.|.|| . .
fieeyeklaaigvd......ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

IIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQqRVTKDFMIRTLKA-TRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE-P
.|||  .| | |. || ||| |. .|  .||. |... . . .. .. |..|  ... |..  .|..||||||||||.. | .|.  | |..... ..  
aivmvtreieagklkChrYWPddnselkygdvtvkstae.eekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PIVVHCSAGCGRTGTICVIDYVRNALQleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH
|.|.||||| |||||   .| . .|..  .  .. .. ... ..||.|  .|||  ||| |..||.|... .
plvihCsaGvGrtGtyialDrlvkave..aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_PTPRA_pd Subfamily PTPRA 25-296 9.1e-73 240.0 In-house 29-295 (330) alignment
Range on Protein: 25-296
Range on HMM: 29-295/330.0
DGSDSFELEFNHLKQISQRYRTEkvyptsAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLW
| .  |  ||| |   . .   |      . . . |..|||. .|||.|.||  ||... || |||.|| |..|  . ....|||||. .||..||||.|
ddnklfreefnalPagpiqatle......laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

ECNTEIIVMACNEFELGRHKCERYWVDEGEeHCFGDILVtQIGQQRVTKDFMIRTLK------ATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLV
| ..  |||  .  |  ..||..|| |||    .|.| | .. .. |..|. .| .       |||.|.... .|||.|.||| |||.  . .|...| |
eqksativmltelkerkeekcaqywPdeGl.vtyGnirv.evedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkv

REYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
.. .  .  ||||||||| ||||| .|.| | . .   | ..   .....  .|.||  .||| .|||...... . .
kklnqqsagpivvhcsaGvGrtGtfivldavlerv...kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 13-298 3.5e-72 238.1 In-house 13-285 (319) alignment
Range on Protein: 13-298
Range on HMM: 13-285/319.0
HYENMADlssslDGSDSFELEFNHLKQISQRyrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPL
.....|.      |. ..| ||..||. ..         ..  . . | .||||..||..|..|  ||..|.||||||.||.|. |  . . ..|.|.||
rlkalas.....tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

PHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWvDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVK
 .|...||||.|| .. |.|| ..  | .. |...|| .| . . .| ..||   ... ..|..|| ||      . | .   .|.||.||||.||.. .
entiedfWrmvWeeessivvmltklveklkvklkkyw.peenfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

PILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
 .||..| .|. .   .. ||||||||| ||||| .|.| . . ...|   .   .. ..  .| ||  .||. .||.... |.... .|
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkee...gvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_Ptp69D_pd Subfamily Ptp69D 30-297 2.6e-71 235.2 In-house 24-287 (307) alignment
Range on Protein: 30-297
Range on HMM: 24-287/307.0
FELEFNHLKQIsqryrtEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
.. |...|..       |    |...| . |  ||||.|| .||. |  |..|   | |||.||.|.||  . ....|||.|.  |...||||..| . .
lakeyekLear......eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

IIVMACNEFELGRHKCERYWVDEgEEHCFGDILVTQIgQQRVTKDFMIRTLKATRDKE-------EKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ
.|||  |. |  |.||..|| .| .|  .|||||. . ... ..|..||.|. .. ||       ..   |.|||.|.|  || . . .|..|. ||| .
livmlsnlteknrkkcakYWpie.devqygdilvklv.seekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

TAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
  .. ||||||||| ||.|..  .| . . |..|   .. ...... |.|.||  .||  .||. ..||..|. .
klnrsPivvhCsaGvgrsgifvaldsllqqlkae...dkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 15-297 2.9e-71 235.2 In-house 15-291 (298) alignment
Range on Protein: 15-297
Range on HMM: 15-291/298.0
ENMADLSSSLDgSDSFELEFNHLKQISQRYRTEKvypTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPH
...|. . . .    ..|||..|...|.. ..|.   ....... | .|||| ||...|.|| .|...|. | |||.|| ||... . ....|.|.||..
qklaavkkkkk.ltgyalefqrlnsvsseieeee...kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte

TVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTqIGQQRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPIL
||..||||..| . . |||  |  ||.. |...|| |||.|. .|.| |. . .. .  |...|.|| .. |  .|.   |.|.| |||.|||.  . .|
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegket.ygeitvs.llskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvl

DMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVrnaLQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|... || .|.   . |..|.|||| ||.|| ..|| |   |.  |..|   .....  .||.| ..|||..||  .. || ....
dllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsv...lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

0037934 (Phosphotyrosine protein) phosphatases II 57-294 3.8e-71 234.8 In-house 7-240 (243) alignment
Range on Protein: 57-294
Range on HMM: 7-240/243.0
SDVNMRKNRYKDILPFDHSRYLLsqidnvEGSDYVNANFLKGAanDhTYLAAQGPLPHTVNE----FWRMLWECNTEIIVMACNEFELGRHKCERYWVde
. .|. ||||.||||.||||  |      |||||.|||. ..   . .. | |||||.||..    ||||||| ....||| ....|||| ||..||   
lpenlsknrysdilpydhsrvkl......egsdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

GEEhCFGDILVTQIGQQRvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREY--------QTAEEPPIVVHCSAGCGRTG
||. ..||. || ....  ..|...|||. ..   |....   ..||..|||||||.|....||... |||.        .  .. |..||||||.||||
gev.tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TICVIDYVRNALqlekidqNFSLYDIIVDMRKQRHA-IVQTRNQYELVHRAVVD
|.......   |       ...|.... ..|.||.  .|||..||. ...|.  
tliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 25-298 8.5e-69 227.2 In-house 16-289 (563) alignment
Range on Protein: 25-298
Range on HMM: 16-289/563.0
DGSDSFELEFNhlkQISQRYrTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGS-DYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRML
||   |. ||.   .. ..  ..|  .... .   | ||||| .|...|.||  ||.. ..... ||.|||...|    . ..|.||||..|.. ||||.
dgdigfseefe...alqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmi

WECNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTQIGQQRV----TKDFMIRT--LKATRD-KEEKIFNQFHYTAWPDHGVPTSVKPILDMIK
|| |..||||  |  | ||.||..||  .. |. .| . ||.| ....    .. ..|.   ||.... ..||   |.||| |||||||..  | | ..|
WeqnvaiivmitnlvergrrkcdvYWPkdeset.ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

LVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
     . ||  ||||||||| ||||| .|.| . . .| |..     .....  .| ||  .|||..||  .| |.... ..
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 37-297 1e-67 223.3 In-house 26-280 (315) alignment
Range on Protein: 37-297
Range on HMM: 26-280/315.0
LKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
.||  .     ...|        | .|||| .|...|.||  |  ..| ..||||||||..| .  . |.|||||.. .|..|||...| .   |||  |
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

EFELGRHKCERYWVDEgeEHCFGDILVTQIGQQrVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAG
  |  ..|.|.|| |.  .  .| | ||.. .. | ... .|||  . ... .   |.|||.||| ||| .  |....|. |. ..|..  .||||||||
lvegekrkaekywpdk..kviyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaG

CGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 ||||| . .| | . .. |..     .|..|  .|..|  .||. .||.... |... | 
vGrtGtfitldavldqaeaena...idvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_PTPN3_pd Subfamily PTPN3 37-297 1.3e-67 222.7 In-house 18-276 (280) alignment
Range on Protein: 37-297
Range on HMM: 18-276/280.0
LKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLKGAAND----HTYLAAQGPLPHTVNEFWRMLWECNTEIIV
|.|  | || ..   .||     |. ||||.||||.|. |  |.. ..    ||.|||...   .       |.|.||||..|...||.|.|| ....||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MACNEFELGRHKCERYWVDEGEEHCFGDILVTqIGQQRVTKDFMIRTL--KATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIV
|  .  | || || .|| ....|  .|.. |. . ... || ...| |  | .. |||.   |. |.||||||||.. . .|.... ||......| |.|
mlttlverGrvkChqyWPetedeleygefsvk.cekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvv

VHCSAGCGRTGTICVIDyvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|||||| |||| . ...    ||.|  . ...   ||.  || || ..||| .||..|  |.. ...
vhCsaGigrtGvlille...talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

subfamily_PTPN9_pd Subfamily PTPN9 56-296 3e-67 221.7 In-house 38-290 (297) alignment
Range on Protein: 56-296
Range on HMM: 38-290/297.0
ESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGE
.. .|..||||.|.| .|..|  |...|. | |||.||||. |  . ....|.||||..||..||||.|| .. .|||.    | || || .||  .|..
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

EHCFGDILVTQIGQQrVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT-------------AEEPPIVVHCSAGCGR
 . |||. |... .. ...|...|.|...  ...|..    | ...|||.||| | . .||... |||.|.             ...|||||||||| ||
saefgdlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

TGTICVIDYVRNALQleKIdQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
||| . .|.  . |.  .. ..  . . .  .|.||   .|| .|||. . ||..  
tGtfitldiclsrle..ev.gtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 48-298 6.1e-67 220.9 In-house 34-285 (305) alignment
Range on Protein: 48-298
Range on HMM: 34-285/305.0
KVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCER
.  ..  |....| .|||.|.| ..|..|. |.. .... |||.||....|  . ..|..|||||..||..|||...|. .. ||| ..  | |..||..
eeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrq

YWVDEGEE-HCFGDILVTqIGQQRVTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEP-PIVVHCSAGCGRTGT
|| ..  | . ||.. |. . ... ..|...| ||..    |||..   |.. | |||||||..   .|..|| |.. |  ..  |..|||||| ||||.
YWpesktekkefgefsve.lksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

ICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
 ...|   . |. |   .   .....  .|..|  .||| .||  .| |. .. ..
fiavdialerlkkE...evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

subfamily_PTPN13_pd Subfamily PTPN13 33-297 4.9e-66 217.8 In-house 16-270 (273) alignment
Range on Protein: 33-297
Range on HMM: 16-270/273.0
EFNHLKQISQRYRtekvypTSAGESDVNMRKNRYKDILPFDHSRYLLSQidnvEGSdYVNANFLKGA--ANDHTYLAAQGPLPHTVNEFWRMLWECNTEI
||..|...    .      .. |... |..||||...||.|..|  |..    ||. |.||...|     . ..|.|.|||||.||..||.|.|| ..|.
efkelrelkpldt......cevgkkkenkdknryrnvlPydetrvklgd....egg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

IVMACNEFELGRHKCERYWVDEGEEHC-FGD-ILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaEE
|.|  .| | |. ||.||| .. ...    . . |.....|.  ..| .|.|. .  . .| .   ......|||||||.| ...| ... ||. || ..
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqk.ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.da

PPIVVHCSAGCGRTGTICVIDYVrnaLQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 ||||||||| ||.||. .|| |   |.| . |..| . .|. ..|.||...|||..|| .|..|......
gPivvhcsaGiGrsGtlitidvv...lglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 54-297 3.2e-65 214.8 In-house 3-243 (250) alignment
Range on Protein: 54-297
Range on HMM: 3-243/250.0
AGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHkCERYWVDEG
 ..   |  |||| ||...|.|| .| . .  . |||.|| ||.|  . ....|.||||..|...||||..| ... |||  |  | ..  ...||  |.
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

EEHcFGDILVTQIgQQRVTKDFMIRTLKATRDKEE--KIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVR
 |. .||..|.   .. .  |...|.|| .. |..  .|  |.|...||| |||   . .|...| |.  |   .. |..|.|||| ||.|. ..|| | 
aek.yGdvtvsll.skeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

NALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
. |   |...   ....|  .||.|   |....||  |....  . .
erl...kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 53-296 1.2e-63 209.7 In-house 13-264 (270) alignment
Range on Protein: 53-296
Range on HMM: 13-264/270.0
SAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAAN-DHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD
.  |   . . |||.||||  ..|  |..... . . |.|||...|. . ...|.||.|||| |...||||.|| ... |||. .  | ||.||||||  
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

EGEE---HCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVK------PILDMIKLVREYQTAE--EPPIVVHCSAGCGRT
| .|     .|.| |... ... .. .... |. ... ||.    |.|..|||||||..         .| |.. ||....    . |..|||||| |||
epkekvkledgkikvlalseek.eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
||. ..|.. ..|. .   ..  .  || ..||.| |.||. .|||....|||   
GtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_PTPRK_pd Subfamily PTPRK 55-294 1e-62 206.8 In-house 38-275 (314) alignment
Range on Protein: 55-294
Range on HMM: 38-275/314.0
GESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGE
   | | .|||..|||..|.||  | .||.   |||.||... .  . . ....||||..||..|||.... |.  |||  .  | || || .|| ...|
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

EhcFGDILVTQIGQqRVTKDFMIRTLKATR----DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVR
   .||| |. .    . .....|... ..     .| .. .||....||||.||.| . .|.... | . |  |. .||||||||.||||| ..|| | 
v..ygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

NALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
. .. |..     .. .. ..|...  .|.| .|| ... ....
dmieregv...vdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 13-316 9.4e-62 204.1 In-house 19-312 (319) alignment
Range on Protein: 13-316
Range on HMM: 19-312/319.0
HYENMADLSSSLDGSDSFELEFNHLKQISQRYRTeKVYptsaGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPL
.| ...  |   |    .| ||... ...    . . .     . | |  |||. .||.||...  | ... .|.|||.|| |..|  .   |.||||||
yyqqlsnksdfdddltklevefrracklgvnlad.qtf....anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PHTVNEFWRMLWECNTEIIVMACnefelgRHKCERYWVDEGEEH-CFGDILVTQIGQqrvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSV
. |...||||.|| |.  ||.        ..|| .||  .....   ... |. . .   |.....| .. ..    |. .  .|||.  |||.||| . 
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee...taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp

KPILDMIKLVREYQTAE--EPPIVVHCSAGCGRTGTICVIDYVRNALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD-MFQAHLGIKPE
 ... ..| ||  .. |  . .||||||||.||||.  |.| . . .. ||      .|... |.|.||  .||   || ... |...  . .|  .   
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp

DYGHNYENVQL
|.   .|.   
dfpayleelsn

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 47-295 1.1e-61 203.5 In-house 30-275 (515) alignment
Range on Protein: 47-295
Range on HMM: 30-275/515.0
EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCE
 ..|| .  . ..| .|||||.|||.| .|  |  |..   |||.|| ....  ||..|.|.|||.. .|..|||.... |.  |.|  .  |  . || 
pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcg

RYWVD-EGEEHCFGDILVTQIGQQRVTkDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICV
.|| |  |.   || | |  .  .  | . ..|.|. ..... .   |||.| |||.|||   . .| .|| |.  .   . |...||||| |||| .. 
kyWPdkpgdsvkfGsikvelvsleact.ggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

IDYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
|| |       |  .   .....  .|..|  .|||..|| ... || . 
idsvvaha...kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 61-294 1.4e-61 203.0 In-house 29-266 (274) alignment
Range on Protein: 61-294
Range on HMM: 29-266/274.0
MRKNRYKDILPFDHSRYLL-SQIDNVEGSDYVNANFLKGAAN-DHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEE---
 .|||||.||| ..|| || |.  . | |.|.|||..||  . ...|.|.|||||.||..||||... ....|||  .  |  ..||..|. |. .    
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

HCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE---PPIVVHCSAGCGRTGTICVIDyvrNA
. .||. ..  .  . ..|. .|.|     ..|.    . ||.|||| .| .....||... |.| ...|.    |.||||||| ||||    |.   .|
erygdveikvekive.rndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais...ia

LQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
..  . ..   .  |....| .|  .|||..||||.|||.. 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 48-295 1e-60 200.2 In-house 32-276 (315) alignment
Range on Protein: 48-295
Range on HMM: 32-276/315.0
KVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCER
..|.. ..  ..|..|||||.|||.|..|  |  ||.   |||.|| ..|.  .|..|.|.||||. .|..||||... ..  |||  .  |  . || .
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWVD-EGEEHCFGDILVTQIGQQRVTkDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVI
|| | ...   || | |. .  .  | | ..| |   . .| .   ||..| |||.||.  .  .| .|| |.  .  .| ...|||||| |||| .. |
ywPdrkadsvefGsikvellsleadt.dgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisi

DYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
| | . .   |  .   .....  .|..|  .|||...| ... || . 
devvaqi...krtrsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 58-317 1e-60 200.6 In-house 23-277 (284) alignment
Range on Protein: 58-317
Range on HMM: 23-277/284.0
DVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACnefelgRHKCERYWVDEGEEH-
| |  |||. .||.||...  | ... .|.|||.|| |..|  . . |.|.||||. |...||||.|| |.  ||.        ..|| .||  ..... 
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

CFGDILVTQIGQqrvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAE--EPPIVVHCSAGCGRTGTICVIDYVRN
  ... |. . .   ......| .. ..    |. .  .|||.  |||.||| .  ... ..| ||  .. |  . .||||||||.||||.  |.| . .
erfkvkvdsvee...seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

ALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD-MFQAHLGIKPEDYGHNYENVQLK
 .. ||      .|... |.|.||  .||   || ... |...  . .|  .   |.   .|.   |
rmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 47-297 2.1e-60 199.4 In-house 38-285 (297) alignment
Range on Protein: 47-297
Range on HMM: 38-285/297.0
EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGaaNDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRhKCE
 ...|.   |  ||. |.|||.|||.| ||  |  ...   |||||| |.||  | | ... | | . ||..||.|... .. .|||  .. |  . || 
aniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kca

RYWVDEGEEHcFGDILVTQIGQQRvTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPT--SVKPILDMIKLVRE-YQTAEEPPIVVHCSAGCGRTG
||| |.|    |||. |.    ..  . |. |.|. |..|   ... .|.... |||. |.   |.. .|..|. ||. ... .| |..|||.|| ||||
ryWsdkgvtt.fGdvsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

TICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 .. || |    .    ...  .....  .|..|  .|||..||..|. ||.... 
vlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_PTPN1_pd Subfamily PTPN1 38-294 3e-58 191.9 In-house 9-269 (290) alignment
Range on Protein: 38-294
Range on HMM: 9-269/290.0
KQISQRYRTEKV-YPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
|.| .  | |   .||.. . . |  .|||.|. |.||||  | . ||    ||.||....    .. |. .|||||.||. ||.|.|| ..  .||  .
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

EFELGRHKCERYWVDEGE--EHCFGD--ILVTQIgQQRVTKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ--TAEEPP
  | .. || .||  . |  |  . |  . |. | .. ... ...|.|. .    .| .   .||||.||| ||| |    |...  |||    . .  |
vvekeqikcaqywPqgeeekellledtklkvkli.seerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

IVVHCSAGCGRTGTICVIDYVRnaLQLEKIDQ--NFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
 |.||||| ||.||.|..| .   ...|| |.  .  . . ....||.|. ..|| .| .. . |...
avihcsaGiGrsGtfclvdtcl..vliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRN_pd Subfamily PTPRN 42-298 1.1e-56 186.8 In-house 39-294 (297) alignment
Range on Protein: 42-298
Range on HMM: 39-294/297.0
QRYRTEKVYpTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFEL
 .|..|.   ....... |..|||.|..||.||||  |..  . | |||.|| ..        .|.|.||||..|| .||.|.||  . .||. ..  | 
cayeaepst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleee

GRHKCERYWVDEGEEhCFGDILVTQIGQQRVTKDFMIRT--LKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCG
| ..|.||| |||.|  ..   |  . .   ..|...|.  ||  . .| .   |||. .||..|||.| |..|.. . |         |||||||.|.|
gvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTICVIDYVRNalQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
|||. ..|| | |  .| |  ..  .   .  .| ||. .|.|..|.|..  ||..  .|
rtGvyilidlvln..rllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 57-296 3e-55 182.6 In-house 45-288 (325) alignment
Range on Protein: 57-296
Range on HMM: 45-288/325.0
SDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRML--WECNteiIVMACNEFELGRHKCERYWVDE-G
   |. |||.|.....|.||  |   ..   |||.||..|.   . ...|||| ||..|.|..||..  |.|    .|.  ||..|| ..|  || .| |
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs...vvvvlneldlgkdrcavywpkemg

EEHCFGDILVTQIGQQRVtKDFMIRTLK--ATRDKEEKIFNQFHYTAWPDHGV---PTSVKPILDMIKLVREYQTA---EEPPIVVHCSAGCGRTGTICV
.   || . |  .  . .  |.. | |.   ... | .  .||.. .|.| ||   |... .||...| | |  ||      ||.|||||| ||||.   
ksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IdYVRNALQLEkiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
. |   |  .|  . .  ... .  .||.| ..|.| .|| |.. |.|...
l.ysalakvie..esrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPN23_pd Subfamily PTPN23 22-295 1.3e-54 180.0 In-house 9-279 (288) alignment
Range on Protein: 22-295
Range on HMM: 9-279/288.0
SSLDGSDSFELEFNHLKQISQRYrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSqidnVEGSDYVNANFLKGAA-NDHTYLAAQGPLPHTVNEFW
. |||  ... .|. |.|  ..        .|   . ..  |||..||||.||.|  |      .  ||.|| |.|. .    ...|.|.||. |.|.||
kmldgktaldkkfkeleqkqdke....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMLWECNTEIIVMACNEFELGRHKCERYW-VDEGEEHCFGDILVTqIGQQRVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKL
.|..|  ...|||  .. |||..|..|||  |.|| . |||. || . ..| |. .. |.|| .  . .. |     ..|.||..||| | . .|.... 
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvt.lksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VRE-YQTA---EEPPIVVHCSAGCGRTGTICVIDYVRNALqlEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
|.. |..     . |.||||||| ||||.....  . ..|  || .    . ...  .|.||.  ||...|.. .  ||.  
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 24-296 1.1e-53 176.9 In-house 16-283 (290) alignment
Range on Protein: 24-296
Range on HMM: 16-283/290.0
LDGSDSFELEFNHLKQisqryrTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEG--SDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWR
  | ..|. .|. |..      .|. . .  | .  | ..||...|.. |  |  | .| . .    .|.|| ..||  ... |.|.|||...|. .||.
akgnegfrnqfkmlds......gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTQIGQQRVTkDFMIRTLKATRDKE---EKIFNQFHYTAWPDHGVPTSVKPILDMIKLV
..|. .. |||| .|. | |..||  || |.. .. .| . .. . .. .. ....|.|. . ...   ...  |.. |.|...|  |  . || .|. .
liwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

RE-YQTAEEPPIVVHCSAGCGRTGTICVIDyvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 .      . .||||||.. ||... |...   ....  |...   .....  .| |.   ||| .||..... |.  .
yktqrkrgntsivvHCSdtvgrsavfcaaa...ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 30-297 7.8e-52 170.8 In-house 12-278 (287) alignment
Range on Protein: 30-297
Range on HMM: 12-278/287.0
FELEFNHLKQISqRYRTeKVYptSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
 . |.. ||. | .  |  ..   | |   ...|||| |.||.|..| |||.  .  ||||.|||.. .  .|....|||||.. ||..|||...| .. 
vdkevdalkeds.esst.atf..kaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsa

IIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRVTKDFMIRTLKAT-RDKEE-KIFNQFHYTAWPDHGVPTS----VKPILDM---IKLVRe
 ...   | | .| || .|| .       |   |. . ..    .. .|.|.    . .| .. .|... .|||.... .    .. .||.   |.| | 
svitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar.

yQTAEEPPIVVHCSAGCGRTGTICV-IDYVRNALQLEKIDQNfslyDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 ...|  |.|||...| ||.|..   .  |.  ..| ..|       ... .|..| |.||.  |. |.  |.|  ..
.dasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdva....avvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 27-294 9.4e-52 170.9 In-house 19-277 (439) alignment
Range on Protein: 27-294
Range on HMM: 19-277/439.0
SDSFELEFNHLKQISQRYRTEKVYptSAgeSDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWEC
 . |. .|.... .|  |. .      |   . .  ||||||. .|||.|  | .|  |  | |.|||..||  .|. |.|.|||  .|...|||...| 
qeifkeifekinstspdyaciasl..aa..qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviek

NTEIIVMACNEFELGRhkcerYWVDEGeEHCFGDILVTqIGQQRVTKDFMIRTLKAT--RD--KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ
.|  ||| .| .|  .     ||  .. | |.||| |  . ..    ...|| .|    ||  . |.   ||||.||||. ||.    .||... .   .
ktvtivmltnlvesyk.....ywpsda.evcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

TA-EEPPIVVHCSAGCGRTGTICVIDYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
   |  |.||||||| ||||||  .|   . |   |....  .  |.  .||||. .||.  || ... ||..
dkeeygpvvvhcsagvGrtGtiialdialeql...klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_PTPN14_pd Subfamily PTPN14 38-297 2.3e-51 169.6 In-house 30-297 (300) alignment
Range on Protein: 38-297
Range on HMM: 30-297/300.0
KQISQRYRtEKVypTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVeGSDYVNANFLKG--AANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMAC
 .|...   . .  .|... ..| .|||.||.||....|  ||   .   ..|.||  .|   ......|..|||||..||..||.|.|| ....|||  
eripkkre.dal..lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NEFELGRHKCERYWVDEGEEHC---FGDILVTQIG-QQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILD---MIKLVREYQTAE---
.| | |..|. .|. ......    ||   ||.   ..  .   .  .||    |||.    . || |||||||  ||. |.   ... ||.  . |   
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

---EPPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
   .||..|||||| |||| . . | . ..|.    ...  .  ..  .|.||  .|||  ||. |..... ...
keskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 25-296 3.3e-51 169.0 In-house 17-278 (287) alignment
Range on Protein: 25-296
Range on HMM: 17-278/287.0
DGSDSFELEFNHLKQISQRyrTEKVyptSAGESDVNMRKNRYKDILPFDHSRYLLSqidnVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLW
 |.. |.  |  |.|..||   ..|     . .  |  |||...||. |  | ||      |  ||.|| |..|  ... ...|..|. .|. .||....
kgnegfknqftvleqvtqr..edev...thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWklid

ECNTEIIVMACNEFELGRHKCERYWVDEGEeHCFGDILVTQIGQQrVTKDFMIRTLKATRDK---EEKIFNQFHYTAWPDHG-VPTSVKPILDMIKLVRE
. | ..||| |.| |  ...| .|| .|    ..|.  .. . .. |......|.|. ....   ...  .|...|.|...| |..    .| . . ...
drnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

YQTAEEPPIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 .   . .||||||.. ||... | ..    ...  | .    .....  .| |.   ||| .||. .  .|. . 
qrkrgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

0041856 (Phosphotyrosine protein) phosphatases II 60-296 3.4e-51 168.7 In-house 1-171 (182) alignment
Range on Protein: 60-296
Range on HMM: 1-171/182.0
NMRKNRYKDILPFDHSRyllsqidnveGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACnefelgrhkCERYWVdegeehcfg
|. ||||.||||.||||          ..||.|||.. |.  . ...|.||||..||..|.|||.| .  .||...         .|.||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dilvtqigqqrvtkdfmirtlkatrDKEEKIFNQFHYTAWPDHGVPTsVKPILDMIKLVREyqtaEEPPIVVHCSAGCGRTGTICVIDYVRNAlqlekid
                         ...|.   |..|. |||||||. .  .||.|. |.|    |. |..||||||.|||||........         
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

qNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 ..||....  .|..|. .|.| ||| ....|. ...
.gvsleeavklvrsrRpgmvitpnqyfflqlallell

0051429 (Phosphotyrosine protein) phosphatases II 86-315 6.5e-48 159.0 In-house 2-244 (272) alignment
Range on Protein: 86-315
Range on HMM: 2-244/272.0
EGSDYVNANFLKGAAN---DHTYLAAQGPLPHTVNEFWRMlWECNTEIIVMACNEFELGRHKCERYWV-----------DEGEEHCFGDILVTQIGQQrV
. |.|.||....|  .   ........||||.|...|||. .| .   ||. ..|.|.||.||.|||            |. ... .|.. || .  . .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.l

TKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVkpILDMIKLVREyqtaeEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQN-----FS
. |...|.| .|     .|   . ..|||.|||||||..   .|....|...     . |..||||||..||||.......   . || | .      . 
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

LYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLGIKPEDYGHNYENVQ
|....  .|.||...|||  ||. ...|..... ..|....| . . .. ..
leeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 47-294 1.5e-47 156.8 In-house 32-234 (392) alignment
Range on Protein: 47-294
Range on HMM: 32-234/392.0
EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNeFELGRhkce
 ..||..... ..|..|||||.|||.| .|  |  ||..  |||.|| ....  |...|.|.||| . ....||||... |.  |.|  . .. |     
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtk.lkegd....

rywvdegeehcfgdilvtqigqqrvtkdfmirtlkatRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVI
                                     . .. .   |||.| |||..||  .  .| .|| |.        |...||||| |||| .  |
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
| |       |  .   ........|..|  .|||..|| ... ||..
dsvvaha...kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_CG7180_pd Subfamily CG7180 30-292 5.9e-47 154.7 In-house 15-286 (296) alignment
Range on Protein: 30-292
Range on HMM: 15-286/296.0
FELEFNHLKQISQRYRTEKVyptSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
|..|.. . .. .| ....     .|    |. |||. ...|.|. | .|...|  | |||.|| .  .   .. |.  ..|  .||.||||.... ...
frveyklelkltprleigdC...agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

IIVMACNEFELGRhKCERYWVDEGeEHCFGDILVTQIGQQRVTkDFMIRTLKATRD------------KEEKIFNQFHYTAWPD-HGVPTSVKPILDMIK
 .|. ...|.  . ..  ||  .. .. .|.|.|  . ..  . .. |||.| |.              |..|  .|..| |.  . || | . ......
avvvLtktfdfak.mypsywpnks.keqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

LVREYQTAE-----EPPIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAV
 || ..        | |.||..| | .|.|  . ||    .|.| ...... ... .  .|..|  .|.. ..|  .   .
rvrlwrekvdedpeegPvvvvssdGasRsGvylaida...nlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 57-294 4.4e-46 152.0 In-house 4-238 (239) alignment
Range on Protein: 57-294
Range on HMM: 4-238/239.0
SDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEE
  ||  |||| .|. .|||| .| .. |   |||.||..|.    . ..|.|.|| .  .  .||||.|.    .|||     |  ..|| .|| |   .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

HCfgDILVTqIGQQRVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVrnaL
.|  .. || . .  |  |..|||.  .   . ||.   |.|.| |||.|||     .| . . . .       | |.||||| ||||.. ||| .   |
yc..nlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam...l

QLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
.  | ..   ... .  .|..|  .||| .|| ..| ||..
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 56-293 4.7e-46 151.9 In-house 4-238 (239) alignment
Range on Protein: 56-293
Range on HMM: 4-238/239.0
ESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGE
.  ||  |||| .|. .|||| .| .. |   |||.||..|.    . ..|.|.|| .  .  .||||.|.    .|||     |  ..|| .|| |   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

EHCfgDILVTqIGQQRVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVrna
..|  .. || . .  |  |..|||.  .   . ||.   |.|.| |||.|||     .| . . . .       | |.||||| ||||.. ||| .   
kyc..nlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam...

LQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
|.  | ..   ... .  .|..|  .||| .|| ..| ||.
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 58-298 4.7e-45 148.9 In-house 39-279 (307) alignment
Range on Protein: 58-298
Range on HMM: 39-279/307.0
DVNMRKNRYKDILPFDHSRYLLSqIDNVeGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYW-VDEGEEH
. |  ||||.|.   |..| ..  .| .  |||. ||.|  | . . ...|||||  |. .|| |  . . | ..| |.  ||.. |||.|| ..||.. 
santdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

CFGD----ILVTQIGQQRVTKD---FMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVReyqtAEEPPIVVHCSAGCGRTGTICVIDYV
 ||.    | |...| .... |     . |||    .. .  ... .. |||.|||      ..... ||     .. |.||||||| ||.|||  | .|
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislv

RNALqLEKIdQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
.. . .. |    .. ... ..|.|||  .||  ||  .|| ... |  
qdkm.iaGi.nckdmkklveelrsqrhyaiqteaqylylhrvlleyfle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 60-293 7.1e-45 148.1 In-house 3-236 (237) alignment
Range on Protein: 60-293
Range on HMM: 3-236/237.0
NMRKNRYKDILPFDHSRYLLSQIDnvEGSDYVNANFLKGAA-NDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCF
|  |||| .|  .|||| .|       ||||.||..|||     ..|.||||||  . ..||.|.|. .  .|||     |  . || .|| .  .  ..
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDILVTqIGQQRVTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVRE--YQTAEEPPIVVHCSAGCGRTGTICVIDYVrnaL
| . |. . ..    |. .|.|  ..    || ..  |...|.|||.|||     .| . | . .     .|  | ..||||| |||| . ||| .   |
gvltvs.lkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam...l

QLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
.  |  .   .|. .  . ..|  |.||..|| ..|....
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

0046846 (Phosphotyrosine protein) phosphatases II 85-293 4e-44 145.8 In-house 9-170 (176) alignment
Range on Protein: 85-293
Range on HMM: 9-170/176.0
VEGSDYVNANFLKGAAndhtYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCfgdilvtqigqqrvtkdfmirtlkatr
 ...||.|||.. |..    ..| |||||.|. .|..||.| . ...|. ..|.||||.|| .|| .. ....                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

dkeekifnQFHYTAWPDHGVPTSvKPILDMIKLVREYQTAEePPIVVHCSAGCGRTGTICVIDYVRNalqlekiDQNFSLYDIIVDMRKQRH-AIVQTRN
        |.... |||||||.. . .|......||....   |..||||||.|||||..... ..        ....|.....  .|.||.  .|||..
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqtpe

QYELVHRAVV
||. ..... 
Qyrflyefel

0043147 (Phosphotyrosine protein) phosphatases II 86-289 5e-44 145.4 In-house 3-154 (172) alignment
Range on Protein: 86-289
Range on HMM: 3-154/172.0
EGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEfelgrhkcerywvdegeehcfgdilvtqigqqrvtkdfmirtlKATRD
|||||.||..|..    . ..| ||||..|...|||||.| .  .||.....                                             ...
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

KEEKIFNQFHYTAWPDHGVPtSVKPILDMIKLVRE-YQTAEEPPIVVHCSAGCGRTGTICVIDYVRnalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQ
..|.   |..|. ||||||| . . .|.......| ..  .. |..||||||.|||||........         ...||....  .|..|  .||. .|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YELVH
| ...
yrfly

0049772 (Phosphotyrosine protein) phosphatases II 58-297 6.7e-44 146.2 In-house 44-281 (314) alignment
Range on Protein: 58-297
Range on HMM: 44-281/314.0
DVNMRKNRYKDILPFDhSRYLLsQIDNVEGSDYVNANFLKGAandHTYLAAQGPLPHTVNEF----------WRML--WECNTEIIVM------------
 .|. ||||.||||.| .|. | .  .|.|||| ||....|     ...|.||||..||. |          |||   .. |. .|||            
flnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------ACNEFELGRHKCERYWVDEGeehcfgdilvtqigqqrvtkdfmirtlkaT----RDKEEKIFNQFHYTAWPDHGVPtSVKPILDMIKLVRE
          ..  ..| . ..... .                               .    ... |.   ..... .||...| . . .........|
LdaAlgKtpllildgngneptaadlellk.............................eelydpelferlgikylripvpDgsap.lledfdeflefiee

YqtAEEPPIVVHCSAGCGRTGTICVIDYVRNALqlekidqNFSLYDIIVDMRKQRH-----AIVQTRNQYELVHRAVVDMFQ
.   .. |..|||.||.||||| .|..|.  .|       ..|| ... |.|..|.       ... .||| ...|. . ..
a..dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 57-296 2e-43 143.1 In-house 53-283 (290) alignment
Range on Protein: 57-296
Range on HMM: 53-283/290.0
SDVNMRKNRYKDILPFDHSRYLLSqiDNVEGsDYVNANFLKGAanDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-EGEE
 . ...||||||.   | .| .|.  |  .| ||| ||..||   . ... .||.|  || ..|||. . ..  ||| |. .| |. |||.|. . ||| 
kntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

HCFGDILVTQIGQQRVTKDFMIRTLKATRDKE--EKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCSAGCGRTGTICVIDYvrnAL
  ||.| |.   ..   .. . .||     ..  |.... ..  .|||. |. |   .| ... .|.       |.||||||| |||||.  |.    .|
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaiev...gl

QLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
|.    ... | |..  .|. | . ||   || .. ....|. 
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG

0036282 (Phosphotyrosine protein) phosphatases II 87-289 2.2e-43 143.3 In-house 1-163 (174) alignment
Range on Protein: 87-289
Range on HMM: 1-163/174.0
GSDYVNANFLKGAANDHTYLAAQGPLPhtvneFWRMLWECNTEIIVMACNEFELGRHKCERYWVDegeehcfgdilvtqigqqrvtkdfmirtlkaTRDK
|||| ||..|..      ..| ||||.     ||.||.| . ...|| ..|.|||..|| .|| .                               .|. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EEKIFNQFHYTAWPDHGVPTSVKpILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVRNALQlekiDQNFSLYDIIVDMRKQRHAIVQTRNQY
.|.   |..|. |||||||.. . .|...|.|.|..   .. |..||||||.|||||.......   |           .|..  .|.||. .||| .||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQy

ELVH
. ..
rfly

subfamily_ptpA1_pd Subfamily ptpA1 46-246 4.9e-43 142.4 In-house 31-249 (418) alignment
Range on Protein: 46-246
Range on HMM: 31-249/418.0
TEKVYP--TSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANdHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRH
 | | |  || |.   |  |||| .||| .|.|  | .|.. |||||.|||.. ||   . ....||||| |. .||||.||    ||||   | |  | 
eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencri

KCERYWVDE--GEE--------HCFGDILVTQIG-QQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA------EE
||.||| ..  ||.          ||   |  .   |   .. . | .. | . | .   |..|  |||| .|   .|. .... . . |         .
kcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn

PPIVVHCSAGCGRTGTICVI
 ||.|||||| |||||.|  
vpiivhcsagvgrtgtfcta

0049260 (Phosphotyrosine protein) phosphatases II 96-289 1.5e-42 140.1 In-house 2-143 (152) alignment
Range on Protein: 96-289
Range on HMM: 2-143/152.0
LKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWvdegeehcfgdilvtqigqqrvtkdfmirtlkatrdkeekifnQFH
..| |. . ..|.|||.|.|...|||||.| .  .||| ....|||. |||.|.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

YTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRnalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
.. |||||||..   .|..........  .. |..||||||.|||||........         ...||....  .|..|  .|.. .|.....
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 26-297 5.3e-42 138.5 In-house 22-290 (305) alignment
Range on Protein: 26-297
Range on HMM: 22-290/305.0
GSDSFELEFNHLKQISQRYRTEKVYPTsAGESDVNMRKNRYKDILPFDHSRYLLsqiDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLW
| | .  || .| . ..   |.... .    .|... ||||.|.   |.|  .|   |.   |||. ||..      .. ...||||| .|..||| |. 
gvdklreefrglakytrpdmtqvafna.nqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmvi

ECNTEIIVMACNEFELGRHKCERYWV-DEGEEHCF-GDILVTQI-GQQRVTKDF--MIRTLKATRDKEEKI-FNQFHYTAWPDHGVPTSVKPILDMIKLV
. . | ||| |.  |||. || .||    || . . . |.| .. | . . .|    | .|. |   ..|.   ....| ||| |||      |...  .
qnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai

REYQTaeepPIVVHCSAGCGRTGTICVIDYVRNALQLEKidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|  .     ||||||||| ||||||  |.|. . .  .|  .   . ...  .| ||   .|.  ||  .|| ... | 
rgskv....pivvhcsagigrtgtivaieyilekiaenk..pcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 29-294 5.3e-42 138.6 In-house 7-264 (283) alignment
Range on Protein: 29-294
Range on HMM: 7-264/283.0
SFELEFNHLKQISQRYrtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLK---GAANDHTYLAAQGPLPHTVNEFWRMLWE
...| .. ||..|         ..    .| | ||||...|.| |  |  |    .    ||.|| |.       .|. |..||.|| .|| .||.|...
nnklfrevlkrlsvpd.....ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

CNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTqIGQQRVTKDFMIRTLKATRD---KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ
 .   |||  .  |  | || .||  .| |  .|.  || . ..   . |.|. |    .   |.. .   . .  | . |  . .  .. . |..   .
ekitaivmltklqedlrikCsqyWPkrGsed.yGeftvt.lrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt

TAEEPPIVVHCSAGCGRTGTICVIDY-VRNALQLEKIDqnfsLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
  .. |||||||.| |||.. . .   | .||    .|    .. ..  ||.||  .|||..|| ||| .|..
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvd....vfavvkimreqrmmavqtldqyklvhelvle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 38-297 2e-41 136.7 In-house 18-294 (301) alignment
Range on Protein: 38-297
Range on HMM: 18-294/301.0
KQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDN--VEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMAC
..  .. ....  ... | |. | . ||.|.| ..|. | .|..  |  .   .|.||....|  . . . |||||. .|. .|||..|.  .  ||| .
eeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

NEFELGRHKCERYWVD-EGEEHCFGDILVTQIgQQRVTKDFMIRTLK-----------------ATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMI-K
|. |  ..|||.|| . | |.. || . || . .. |  ||.|| |.                  ..||. .   |.. | ||..||    . .|  | .
nlkegtkskceqywpnseaeseefgpftvtlv.neqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

LVREYQTAEEPPIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 .   |  .  |.|||||.. .|.|. | ..    .|   | .    .....  .|...   |.| .||  .. ..  ..|
vihrqqkigggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 56-299 2.1e-38 126.6 In-house 33-272 (281) alignment
Range on Protein: 56-299
Range on HMM: 33-272/281.0
ESDVNMRKNRYKDILPFDHSRYLLSQ-IDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGE
.  || .|||| .|  .| ||  |   . | . .||. ||...     . |. .|||   |  .||||.|. ||  ||| |.  |  | ||  |.  .  
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

EHCFGDILVTQIGQQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPildMIKLVREYQTAEEPPiVVHCSAGCGRTGTICVIDyvrnaLQ
     | |  .  .  | | ..   |. . . | ..  .. .  |||  || | .    |.|..|. ..   || |.||||| ||.||.  ..     . 
cclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev...mlkilrkirarstpp.vihcsagvgrsgtlmave.....ia

LEKIDQNFSLYDI---IVDMRK-QRHAIVQTRNQYELVHRAVVDMFQAH
|. |   |.| ||   .  .|   | | ||| .|| |. . ..|.  |.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 55-294 4.2e-38 125.9 In-house 28-293 (297) alignment
Range on Protein: 55-294
Range on HMM: 28-293/297.0
GESDVNMRKNRYKDILPFDHSRYLLSQidNVEGSDYVNANFLKGAA--NDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-
   .  .|||||.||| .| .|  | .   . ..||.||...      .|  |. |||||  ||..||....| .  .||| ..  | ||.||  || . 
akrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

EGEEHCFGDILVTQIGQQRVTKD-FMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSV-----------------KPILDMIK-------LVREYQTAEE
..|    ||..|  . .     |  ..  |.    .|..  .   . .|||||||. .                   .| ...       |  |   || 
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

P---PIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSlydIIVDMRKQRHAIVQTRNQYELVHRAVVD
|   ...|||||| ||.| .   | . . |. ..| .  .   |.  .|.||  .||| .|.||.. ||. 
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaa...ilsilreqrarlvqtleqfellydavlk

0044763 (Phosphotyrosine protein) phosphatases II 71-290 9.3e-38 125.0 In-house 1-165 (178) alignment
Range on Protein: 71-290
Range on HMM: 1-165/178.0
PFDHSRYLLSQIDNVEGSDYVNANFLKgaanDHTYLAAQGPlphtvNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEehcfgdilvtqigqqr
|.|..|.||| . ..|.||| ||..      .. ||....|      .....|.| .   ||. ..|.|||..|| .||..| .                
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vtkdfmirtlkatrdkeekifNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAlqlekidqNFSLYDIIVD
                      |.... .||||||.. . .|.......|..  .. |..|||||| ||.||........          ..||...|  
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRKQRHaIVQTRNQYELVHR
.|..|  ||....|.. ...
vrerRp.ivpnpgqlrqLye

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 60-298 2.1e-37 123.5 In-house 48-289 (305) alignment
Range on Protein: 60-298
Range on HMM: 48-289/305.0
NMRKNRYKDILPFDHSRYLLsqiDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-EGEEHCF
.  ||||||.  .|. |  |   ..    .|. ||..   .| . .. .| || .|  .|| | .. . | | | ||  | | .||  |.   ....  |
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

GD--ILVTQIGQQRVTKDFM-------IRT---LKATrDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYqtaeEPPIVVHCSAGCGRTGTICVI
 .    ..   .  || .|         .|   .. .  .. .  ...|.  ||| |||..   ||....  |        ||||||||| ||||.. ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvml

DYVRNALQLEK-IDQNfslYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
.|. . |   . |..      |.. .|.||   .|| .|| .||. ....|. 
eyildqllagqiiedt...dkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 60-295 1e-36 121.5 In-house 43-270 (288) alignment
Range on Protein: 60-295
Range on HMM: 43-270/288.0
NMRKNRYKDILPFDHSRYLLSqidnVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYW-VDEGEEHCF
|  ..||...   | .|  ||     .   |..|| .  | ...  . || ||  |..|.|.|| | . | ||| |.  |.|..| . |. .  ||.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDI-LVTQIGQQRVTKDFMIRTLKATRDKEEKI-FNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCSAGCGRTGTICVIDYvrnALQLE
| .  |..  .. . |   . .|. ..  |||.   . |.  |.|.||| . .. | ... ....|     |||||.||| |||||. .|     ||.  
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlilili...alesl

KIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
..| . ..  ..  .|..|   .|| .||  ||| | . 
rlddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 60-293 1.4e-34 114.1 In-house 52-287 (310) alignment
Range on Protein: 60-293
Range on HMM: 52-287/310.0
NMRKNRYKDILPFDHSRYLLsQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFG
.| |||| |..  | ||  | .||.    ||. ||..|      |.. .|||| ||. .||||...  .| |.. |.  | || ||  ||   |    .|
ymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

DILVTQIGQQrvTKDFMIRTLKATR------------DKEEKIFNQFHYTAWPDHGVPTSVKPILDMiKLVreyQTAEEPPIVVHCSAGCGRTGTICVID
 | ||....   ...| |  |  |             . .|   .  ..  ||| |||      .   .|.         | ||||||| .|..... ..
cirvtnlses..seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rll...aqvrhgpcvvhcsagkdrlyvvvalk

YVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
.  . |.     ..  . ... ...|.|   .||  || ...|  .
lkidkldr...glkvdaeevktellksraiciqtelqyliidrvri

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 27-298 7.7e-34 111.9 In-house 5-261 (267) alignment
Range on Protein: 27-298
Range on HMM: 5-261/267.0
SDSFELEFNHLKQISQRYRTEKVYptsAGeSDvNMRKNRYKDILPFDHSRYLLSQIDNVegsdYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWEC
  ..| ||. .|.||.   |   .    . .. |  .||. | ||.|..|  |.. ..     |.|| ...|    ..... |.||  |. .|. .. . 
eceiekefelikkisdtsstisqs...ia.ek.nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdq

NTEIIVMACNEFElgrHKCERYWVDE-GEEHCFGDILVTQiGQQRVTKDFMIRTLKAtRDKEEKIFNQ--FHYTAWpdhGVPTSVKPILDMIK--LVREY
.  .||.  . |.    .  ..|  . |. . . |. | .   ..  .|. | ||.  . |.|  .|   ..|  |    . |  || |  .   | .. 
kvpvivlltkvft...dnirlfwPPkmgqakkyqdltveh.slekeendyqiitlel.kfknesahnvtlyyykkw...nintnnkpylkplfgilaknq

QTAEEPPIVVHCSAGCGRTGTICVIDyvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
    ..|.||.||.| ||.||  |||     |.  | ..   ..| .  .|.|| ..|.|...|  .|. ...  . 
lengnrPlvvacsdGvGrsGtflvid...sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 57-296 5.2e-33 109.2 In-house 32-270 (285) alignment
Range on Protein: 57-296
Range on HMM: 32-270/285.0
SDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLKGAAND-HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE-GE
 . |   ||| |.   . .| .| . |     ||. |....   .|  ||...||||| |...||.|... .   ..| |  || |  ||  |. .. ||
yeanpdlnryadvrcieetrvvlknhdr....dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

EHCFGD--ILVTQIGQQRVTKDFM-IRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAeEPPIVVHCSAGCGRTGTICVIDYV
   ||   | .|.  .. ..   .   |.  | |   |   .|. .   |||.  |   .|.... | |.. .   | ||.|||||| ||| |.  ||| 
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidya

RNALqLEkiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
   . .|  . |  . ||. .||  |   ||.. |. ...  ... |
tiri.me..npniemldivremramrfqavqshmqflflyvvlmeyf

PTPc_DSPc_SM00012 192-293 2.8e-32 106.4 In-house 3-104 (105) alignment
Range on Protein: 192-293
Range on HMM: 3-104/105.0
NQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE--PPIVVHCSAGCGRTGTICVIDYVRNALQLEKidQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
...|||.|||||||.....||.... |.. ....|  .|.|||||||.|||||....|.. . |. |.  .......|.  .||||.  ||| .||  ..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfly

RAVV
||. 
rall

0051082 (Phosphotyrosine protein) phosphatases II 87-291 5.1e-32 105.9 In-house 2-148 (151) alignment
Range on Protein: 87-291
Range on HMM: 2-148/151.0
GSDYVNANFLKGAandhtYLAAQGPLPhtvnEFWRMLWECNTEIIVMACNEFELGrhKCERYWVDEGeehcfgdilvtqigqqrvtkdfmirtlkatrdk
 ||| |.... |      ... .|||.    .|...|.| .   ||. ..|.| |  .| .|. ..|                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

eeKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREyqtAEEPPIVVHCSAGCGRTGTICVIDYVRnaLQlekidqnFSLYDIIVDMRKQRHAIVQTRNQYE
    . ..... |||.|.|.| . .|....|...    .. |..||||||.|||||..... .   |.       .||.... ..|..|. .||. .|. 
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqfl

LVHRA
....|
fqlfa

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 63-299 7.5e-31 102.0 In-house 46-279 (312) alignment
Range on Protein: 63-299
Range on HMM: 46-279/312.0
KNRYKDILPFDHSRYLLSQIDNVegsdYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-----EGEEHC
 ||| .|  .|  |. |.  .|     |. |||.|  ..   ....||||  |.  ||..     .  |.. |   | | .|| .|  |     . |.| 
lnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

FGDILVTQI-----GQQRVTKDFMIRTLKATRdKEEKiFNQFHYTAWPDHGVPTSVKPILDMIKLVREyqtaEEPPIVVHCSAGCGRTGTICVIDYVRNA
     .|.|      ....|.  .   .|||  .| | .|.. ...|||||.| |.   | ..  |.     .  |.. ||||| |||||...|. .  |
vyteycteieiggkskdkithrvlkvvvkatg.qesk.lnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaa

LQLEKiDQNfsLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH
|.  .  ||  . |. | .||.|   |..  ||  . |.|.... ..
lrhpr.kqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 91-285 4.1e-29 96.3 In-house 78-270 (301) alignment
Range on Protein: 91-285
Range on HMM: 78-270/301.0
VNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE-GEEHCFGDILVTQI-GQQRVTKDFMIRTLK---ATRD
. ||...   . | ..|.||||. | ..|| ||   . | ||| ... |   .||| |   . .|.   |   ..    .. . |. . |||.   .|..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREyqtaEEPPIVVHCSAGCGRTGTICVIDYVRNALQlekIDQNFSLYDIIVDMRKQRHAIVQTRNQY
 . .    . |. |.|.||| |   . |...||..     | ||||||||| ||. .    .|. ....    |..  | . . ..|..|   |||..| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareve...adptieltealkhlrehrwngvqtnsql





subfamily_CG42327_pd Subfamily CG42327 61-219 7.7e-27 88.8 In-house 29-191 (319) alignment
Range on Protein: 61-219
Range on HMM: 29-191/319.0
MRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDH-TYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE--G-EEH
  |.|. ...|. ..|  | .| . . . |..|....|  . .  |.||| .|  .  .|||..|| .. .|| ... .||| ..| .|.  .  . ...
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

CFGDILVTQIGqQRVTKDFMIRTLKATRDKEEKIFNQFH--YtAWPDHGVPTSVKPILDMIKLVR
 .||||||  | . | . ..| ||   | ..|.  .  |  |  |.. .||.. .... |.  ||
lyGdilvtlkg.revkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

0048076 (Phosphotyrosine protein) phosphatases II 175-292 1.1e-26 88.6 In-house 31-139 (145) alignment
Range on Protein: 175-292
Range on HMM: 31-139/145.0
FMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEePPIVVHCSAGCGRTGTICVIDYVRNalqlekidQNFSLYDIIVDMRKQ
 .. .|  ... .|.   |..|. |||||||.. . .|.......|.. ..  |..||||||.|||||..... ..         ...||....  .|.|
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsq

RHAIVQTRNQYELVHRAV
|. .|.. .|.. .....
rpgavpnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 176-290 2.1e-25 84.5 In-house 32-139 (144) alignment
Range on Protein: 176-290
Range on HMM: 32-139/144.0
MIRTLKATRDKEEKIFN--QFHYTAWPDHGVPTSVKPILDMIKLVREYQTaEEPPIVVHCSAGCGRTGTICVIDYVRnalqlekiDQNFSLYDIIVDMRK
.. .|  ....|. ...  |.... |||||||.. . .|.......|..  |. |..||||||.|||||..... ..         ...||....  .|.
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrs

QRHAIVQTRNQYELVHR
.|  .|....|.. ...
rrpgavpnpgqlrfLle

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 110-286 5.4e-25 82.4 In-house 98-278 (302) alignment
Range on Protein: 110-286
Range on HMM: 98-278/302.0
GPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE-GEEHCFGDILVTQIG------QQRVTKDFMIRTLKATRDK----EEKIFNQFHYTA
 |   |.. .| .. . |. |.|  |.  | . .||  |. |. |.|  ||   |. .       .    |.|.. |.. . .|     .|  . ....|
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPTSVKPILDMIKLVREYQTAeeppIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYE
||||| |   .. ||..|    |...    ..|||||| |||||.  | |    .|| . ..   | .|.. .|. |.  ||. .|  
wpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaiky...GiqlcskkkvtdllsivlpvrqcryGavqdeqqli

subfamily_egg_pd Subfamily egg 39-303 2.3e-23 77.4 In-house 21-277 (307) alignment
Range on Protein: 39-303
Range on HMM: 21-277/307.0
QISQRYRTEKVYPTSAgeSDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEF
....    |. . |.|  || |. | | | .   | ||  |         |.. || .||     ... || ||  ||..||||... . . |||     
evleesvdeislttaa..sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrk

ELgrHKCERYWVD-EGEEHCF--GDILVTQIGQQ-RVTKDFMIRTLKATRDKEEKIFNQFHYTawpDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCS
|   ..|| ||   | .   .  | . .. .. . .    | .  ||    ..|. | .       |    . |   | .....|.  .    |.||.. 
es..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg...dvnnssdvysplrvlrklrnlsk....pvvvqdi

AGCGRTGTICVIDYVRNALQLEKIdQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLGIK
 |. ...|.  |.     |    |   . .   .| .|..|.  |..  .| .|.| |. .|.  .|  
lGvskaatlvaieiallsllrGpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 62-152 2.3e-23 77.5 In-house 49-153 (350) alignment
Range on Protein: 62-152
Range on HMM: 49-153/350.0
RKNRYKDILPFDHSRYLLS--------QIDNVEGSDYVNANFLKGA------ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCER
 |||||.|||..|||  |         .   ....||.|||.|| .        |. |.|.|.||| ||..|.... . . ..|..  ...||...||.|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWVDE
|| . 
YWqeg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-325 3e-23 76.8 In-house 87-224 (440) alignment
Range on Protein: 187-325
Range on HMM: 87-224/440.0
EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ-TAEEPPIVVHCSAGCGRTGTICVIDYV-RNAlqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQ
| . ..|.|| .|||.|||  . |.| ||. | | |  | . |..||||||.|||| | ..| . |.|    |  ..  .. .|  ||..|  .||| .|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilrea....krsdqidifsfinsmrnnrpqmvqtpeq

YELVHRAVVDMFQ-AHLGIKPEDYGHNYENVQLKHEHFEQPR
| .|| ||.. .  .   |  .|  .  |..|    | ..  
yafvheavlegllcgdtliledditerveqiqwpnphtdksp

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-292 5.3e-22 72.8 In-house 46-275 (303) alignment
Range on Protein: 59-292
Range on HMM: 46-275/303.0
VNMRKNRYKDILPFDHSRYLLSQidnvegSDYVNANFLKGAANDHTYLaAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCF
 || |||. |.. .|||.  ||.      | |. |..|.  .. .. | .| ||.||  .||.|. | .   ...   . |  .   .  .  . .   |
knmdknrfvdvicldhskvklsd......ssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GD--ILVTQIGQQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTS-----VKPILDMIKLVREYQTAeEPPIVVhCSAGCGRTGTICVIDYVRN
 .  | | .. .  ... . .. |  .  .   ..   || |||   .|.      || | ..  ..| |  . .|.. .   .||||.||.....    
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds.tptvym.slsgcgragtfalfetahl

ALQLEKidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAV
.|. |.    . |   .  .|. |   ||   |. .|.  .
slhseq..asldlvkclenvrngrlhavqnlsqfsvvytll

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 115-296 5.4e-20 66.5 In-house 40-221 (255) alignment
Range on Protein: 115-296
Range on HMM: 40-221/255.0
TVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEG-EEHCFGDILVTQIGqqrVTKDFMIRTLKATR----DKEEKIFNQFHYTAWPDHGVPTSVK
||..|....   .|| .|| |.  | |. ||..|.  |  |   . |. ||       . | ..|||. |      |. .  . ..|. |...  |   .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PILDMIKLVREYQtaeepPIVVHCSAGCGRTGTICVIDYVRN--ALQLEKID-QNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 || ..|.||. .     ..|||||.| ||. .  ....|     ..|.. .  ..    .. ..|..|.. ..|  |  .    |.|..
eilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 190-297 5.3e-18 59.9 In-house 216-345 (350) alignment
Range on Protein: 190-297
Range on HMM: 216-345/350.0
IFNQFHYTAWPDHG---VPTSVKPILD----MI---KLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRN-ALQLEKIDQNF-------SLYD----I
.  |...  |.| .    | |. ..|.    .|        ...|. .||.||||||.|||||.. .|.. .  . ||.. ...        . |    |
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
.  .||||  .||. .|.  .. |.  .|.
vnelrkqrismvqnldqfifiYeallfyfa

subfamily_hpo-7_pd Subfamily hpo-7 112-296 5.5e-18 59.8 In-house 43-227 (263) alignment
Range on Protein: 112-296
Range on HMM: 43-227/263.0
LPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEG-EEHCFGDILVTQIGQQRvtkDFMIRTLKATR----DKEEKIFNQFHYTAWPDHGVPT
|  |...|....   .|| .|| |.  | |. ||..|.  |  |   . .. |.    |    | ...||. .      |. . .... |. |...  |.
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpe

SVKPILDMIKLVREYQtaeepPIVVHCSAGCGRTGTICVIDYVRN--ALQLEKID-QNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
  . || ..|..|. .     ..|||||.| ||.    |.. |     ..|.. .  ..    .. ..|..|.. ..|  |       |.|..
lareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 78-293 1.2e-17 59.0 In-house 36-256 (290) alignment
Range on Protein: 78-293
Range on HMM: 36-256/290.0
LLSQIDNVEGSDYVNANFLKGAaNDHTYLAAQGPLPH-------TVNEFWRMLWECNTEIIVMACNEFELGRH----KCERYWVD-EGEEHCFGDILVTQ
 | .  .   .||. ||... . |.   .. | |. .       |...|| |  . . . .|| |.  |  ..     |..|  . .|||  |... |  
vLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC

iGQQRVTKDFMIRTLKATRDKEE-KIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCSAGCGRTGTICVIDYvrnALQLEK-IDQNFS
  ..   .|. .|.|  . |.||   ..   .  | .  |. . | .|..|. |. ..|    |..|||  |  |  ..  |.    . |.     ....
.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiil...gyQkiaetsgsvk

LYDIIVDMRKQRHAIVQTRNQYELVHRAVV
| |.. ..||||   ... ...  |  ..|
ledvlkalrkqralaitsalelafvdagiv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 62-151 2.4e-15 50.7 In-house 50-155 (349) alignment
Range on Protein: 62-151
Range on HMM: 50-155/349.0
RKNRYKDILPFDHSRYLLSQ--------------IDNVEGSDYVNANFLKGA--ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKC
 |||||||||..|||  | .               |     ||.|||.|| .  . .. |.| | ||| ||..|....   . ....   ...||. .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

ERYWVD
..|| .
diywqe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 192-297 4.9e-15 49.7 In-house 221-345 (349) alignment
Range on Protein: 192-297
Range on HMM: 221-345/349.0
NQFHYTAWPDHGV---PTS------VKP-ILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAL-----QLEKIDQNFSLYDII----VDMR
 |. .  |.| ..   | |      ||. ..|       ..|.. ....|||||||||||... .|.. . |     .  ||. .  | |.|      .|
lqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelr

KQRHAIVQTRNQYELVHRAVVDMFQ
||| ..||  .|.  .. |..  |.
kqrismvqnlaqfiaiyealLkyfa

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 103-289 2.5e-14 47.9 In-house 5-197 (199) alignment
Range on Protein: 103-289
Range on HMM: 5-197/199.0
HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHCFGDILVTQIG---QQRVTKDFMIRTLKATRDKEEKIFNQFHYTA
. |.|.| || .|. .||.|.||  .  |||  ..          ||   |     .| . ||      .   |   .| | ..|     .   .. .|.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTS---VKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
| ..  |     |  ..   .. . |.   . |..|||| | | || .  .|    . .  |      |...   .|. |  |. . ..|....
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 103-289 2.5e-14 47.9 In-house 4-196 (198) alignment
Range on Protein: 103-289
Range on HMM: 4-196/198.0
HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHCFGDILVTQIG---QQRVTKDFMIRTLKATRDKEEKIFNQFHYTA
. |.|.| || .|. .||.|.||  .  |||  ..          ||   |     .| . ||      .   |   .| | ..|     .   .. .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTS---VKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
| ..  |     |  ..   .. . |.   . |..|||| | | || .  .|    . .  |      |...   .|. |  |. . ..|....
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 60-300 9.6e-13 42.2 In-house 51-289 (302) alignment
Range on Protein: 60-300
Range on HMM: 51-289/302.0
NMRKNRYKDILPFDHSRYLLsqidNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTV---NEFWRMLWECNTEIIVMACNEFELGRhKCERYWVDEGEE-
|..||. .|.   |. .  |    . |  .||||  ..     .. . || |   ..   .||||| .. .   .|..  | || .   . ..  . .. 
nlkknqsedvpildsnlvkl....eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

HCFGDILVTQ--IGQQRVTK-DFMIRTLKATRdKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNA
. .|.. | .  . ..  .|  ..|  |      .  . |  . | |... ||...  .   .. | . ..  . ..|.    |.|| |.. .   . . 
keygkmfvNnrkVekaeeektryviEvlPegc.snsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

LQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
|| .   ..    .|.  .|.|| ..|.. .||  ...|..  .. ..
lqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkv

subfamily_PTPDC1_pd Subfamily PTPDC1 194-290 2.6e-12 41.5 In-house 85-170 (182) alignment
Range on Protein: 194-290
Range on HMM: 85-170/182.0
FHYTAWPDHGVPtSVKPILDMIKLVReyQTAEEPPIVVHCSAGCGRTGTICVIdYVRNAlqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHR
..  .|.|.||. |.. |||..|.|   .. .|  . ||| || |||| .    |.  |       ....  . |  .|..|   .|||.| |||. 
vynfgwkDygva.sleriLdivkvva..falqegkvavhChaGlGrtGvliac.ylvya.......krltaekaiklvrskrpksiqtreqvelvke

subfamily_CG42327_pd Subfamily CG42327 224-299 8.3e-12 39.4 In-house 245-317 (319) alignment
Range on Protein: 224-299
Range on HMM: 245-317/319.0
AEEPPIVVHCSAGCGRTGTICVIDYvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRaVVDMFQAH
 .  |.||||| | ||||..   |   .  .||.  .   . ...  .|..|   |.|..|||.... |. .. ..
esqGPlvvhcsdGvGrtGlviasdi..airsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk.vlseyakk

0038934 (Phosphotyrosine protein) phosphatases II 192-292 2.8e-11 38.9 In-house 80-173 (194) alignment
Range on Protein: 192-292
Range on HMM: 80-173/194.0
NQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVRNalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHR
 ...   .||.|.. | . .|. ..|| |.  . ..  ..||| || |||||...   .          ...|. . |  .|  |  ........| ...
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdyleallk

AV
 .
ry

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 50-110 1.6e-10 35.1 In-house 38-95 (95) alignment
Range on Protein: 50-110
Range on HMM: 38-95/95.0
YPTSAGESDVNMRKNRYKDILPFDHSRYLLSQidnVEGSDYVNANFLKGAANDHTYLAAQG
 | ..| |. |. |||. .|.|.| .|  |.       |||.|| |. | |    |.||||
apytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_eak_pd Subfamily eak 48-206 3.3e-09 30.6 In-house 40-196 (332) alignment
Range on Protein: 48-206
Range on HMM: 40-196/332.0
KVYPTSAGESDVNMRKNrYKDILPFDHSRYLL-SQIDNVEGsdYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCE
..   | ..   ....|   .|.|.|.    | |   | .|  |.||  .. .   . |. .  .    |  ||.|. | ..  ||.  .. ||.  | .
rllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

RYWVDEG-EEHCFGDILVTQIGQqRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPT
.|. |.. ||  || . |..       . .  | |. ..  | .    ...  | .  .| 
kyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 42-155 3.5e-09 30.6 In-house 16-128 (332) alignment
Range on Protein: 42-155
Range on HMM: 16-128/332.0
QRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEgsDYVNANFLKGAANDHTYLAAQGPLP-HTVNEFWRMLWECNTEIIVMACNEFEL
| . .   || .  .   ||  ||   .  |||||  |.  |  .  |. ||... | ..  .|. || |.  ||   ||||. | .  .|..  .  | 
qmhtsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek

GRHKCERYWVDEGEE
 ..|.     | | |
qkrkapydisdrgfe

PTEN_1 181-244 4.4e-09 31.4 In-house 82-148 (196) alignment
Range on Protein: 181-244
Range on HMM: 82-148/196.0
KATRDKEEKIFNQFH--YTAWPDHGVPTSVKpILDMIKLVREYQTAEE--PPIVVHCSAGCGRTGTIC
....|.|| . ...      ..|||.|.  . ..|..| . |.  . .    ..||| || ||.||..
grsydleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 58-101 1.3e-08 28.7 In-house 37-79 (244) alignment
Range on Protein: 58-101
Range on HMM: 37-79/244.0
DVNMRKNRYKDILPFDHSRYLLSQIdNVEGSDYVNANFLKGAAN
 .|  |||| .|||||..| .||   . |||||.|||...|. |
sanatknryinilpfdetrvilsss.kkegsdyinanyiqgsqn

subfamily_PTEN_pd Subfamily PTEN 168-268 2.9e-08 28.9 In-house 55-155 (184) alignment
Range on Protein: 168-268
Range on HMM: 55-155/184.0
QQRVTKDFMIRTLKATRDKEEKIFN-QFHYTAWPDHgVPTSVKPILDMIKLVREYQTAEEPP-IVVHCSAGCGRTGTICViDYVRNALQLEKIDQNFSLY
... .....|  |.. |. ..| |. . . .   ||  | ... . .... ....  ...   .|||| || ||||.. |  |. ..|.||| ..  .|.
ekkhkdhykiynlrserkydskkfdgrvavypfdDh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllkslllekaeealelf

DII
. .
aea

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 230-295 3.3e-08 27.8 In-house 1-63 (69) alignment
Range on Protein: 230-295
Range on HMM: 1-63/69.0
VVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
|||||.| |||||   |      .. ||.     ... .  ||| |  .|   |.| ..| |.|. 
vvhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 229-295 4.5e-08 27.4 In-house 1-64 (69) alignment
Range on Protein: 229-295
Range on HMM: 1-64/69.0
IVVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
.|||||.| |||||.  |      .. ||.     ... .  ||| |  .|   ..| ..| |.|. 
mvvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 56-127 1e-07 25.8 In-house 33-109 (347) alignment
Range on Protein: 56-127
Range on HMM: 33-109/347.0
ESDVNMRKNRYKDILPFDHSRYLLSQIDNVE-----GSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECN
| . .. ||| ||    | .| .||  .           |.||  .|    .. |. .| |||.|| .||.|.   .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 55-99 1.1e-07 25.6 In-house 42-86 (440) alignment
Range on Protein: 55-99
Range on HMM: 42-86/440.0
GESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA
     |  ||||..|| .|||| .| ..  |  |||.|| ...| 
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 115-301 1.8e-07 24.1 In-house 130-314 (346) alignment
Range on Protein: 115-301
Range on HMM: 130-314/346.0
TVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQ--QRVTKDFMIRTLKATrDKEEKIFNQFHYTAWPDHGVPTSVKPIL
 |..|| |... . ... .   .  |       .  ..|  .  | ... .         |.. |  |    . .  | .  |.. |     |    ||.
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpeg.nsdsvicqvhhhapwkhlqqppktlpii

DMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQlEKIDQNfsLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLG
 ||.     .  ..  . |    ||||. ..    |  | |. . |. |  ...|. ....||   |..  ||  ..  |.|    . |
kmihqflsekqvqnagvcvvslfgcgracsfigalyainqln.ngiepn..iceimknikqqrpggvesfaqyasiyaivfdyiarkrg

subfamily_VSP_pd Subfamily VSP 170-245 2.1e-07 25.1 In-house 71-147 (212) alignment
Range on Protein: 170-245
Range on HMM: 71-147/212.0
RVTKDFMIRTLKATRDKEEKIFN-QFHYTAWPDHGVPTsVKPILDMIKLVREYQTAEEPPI-VVHCSAGCGRTGTICV
. .. . .  | . |. .||.|| . .     || ||. .. .| . | |.|.  ...  . ..||  | ||||||  
khrdhykvvnlcseraydekyfnnrvkriliddhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivc

subfamily_DSP23_pd Subfamily DSP23 200-290 4.1e-07 24.7 In-house 60-140 (148) alignment
Range on Protein: 200-290
Range on HMM: 60-140/148.0
PDHGvPTSVKPILDMIKLVREYQTAEEpPIVVHCSAGCGRTGTICVIDYVRNalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHR
.|.  | ... . .....| | .  .|  . |||  | |||||.    .|..        ....  . | ..|..|   |.| .| .||. 
ddyh.ppaleqvvefvrvveeaeekne.avsvhcllgrgrtgtmlacylvke........rklaaaeaiaevrrlrpgsvetveqeklvrd

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 81-204 8.1e-07 23.4 In-house 6-126 (130) alignment
Range on Protein: 81-204
Range on HMM: 6-126/130.0
QIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN-EFElgrhkcERYWVDEGE-EHCFGDILVTQIgQQRVTKDFMIR
... ..| .|.||.|.    .   || .| ||  |  .||.|. |   ...|.    | |      . || |    |    ||.||   ..   |     
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywpdsePlewyeediivtlt.drdefknikas

TLKATRDKEE--KIFNQFHYTAWPDHGV
 |.  .|  |  . .  |. . ||  | 
nleiesdlneshqaltmfqisnwpsdgt

subfamily_PTPMT1_pd Subfamily PTPMT1 171-285 3.1e-06 21.7 In-house 53-158 (171) alignment
Range on Protein: 171-285
Range on HMM: 53-158/171.0
VTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEpPIVVHCSAGCGRTGTIcVIDYVRNAlqlekidQNFSLYDIIVD
..... ...|  . .. .|   .. . | .|.   .... ... .........  .  . ||| || ||..|. |. |.          ...|. . .  
lneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgk.rvYvHCkaGrgRsatl.vacylmkk.......eklspeeAlka

MRKQRHAIVQTRNQY
..|.|. |   ..|.
lkkkRkiirlakkqw

subfamily_eak_pd Subfamily eak 229-296 3.4e-06 20.7 In-house 239-305 (332) alignment
Range on Protein: 229-296
Range on HMM: 239-305/332.0
IVVHCSAGCGRTGTICVIDYVRNALQlEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 .. .. |  |.|.  ||| . . .. .|.   .|. |.|. ....|   | .  |. ... .|.| .
piiqsarGsaraGvfvvidllirlid.nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 52-134 8e-06 18.9 In-house 19-74 (169) alignment
Range on Protein: 52-134
Range on HMM: 19-74/169.0
TSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNAnflkgaandhtylaaqgplphtvnefwRMLWECNTEIIVMA
    |  .|  |||    |   | |  | .. .  ||||.||                           ||.|| |. .||. 
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl