Gene PTPN14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP058_AA protein Get Run
SpurP058_AA_1023-1313 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN14_pd Subfamily PTPN14 1019-1316 6.9e-154 506.2 In-house 3-300 (300) alignment 
Range on Protein: 1019-1316
Range on HMM: 3-300/300.0
EETKHPRDARRKILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGELLHYIAAQGPM
| |....|.|.|||||.|.||.||||||.|.|||| |...|.|||||...|||||||||||.|||||....|| ||||||..||.|.|. ..||.||||.
eatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl

ENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDD
|.||||.|.||||.|.|.|.|||. .||||||.|||.|...| ||.|.||| |.|...||.||...||.||.|.|.||.|.||||||||.|||..|.|.|
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeD

VHGFLSFLEEFQSVCRHANSMNE-VEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNTR
|.||||.|||.|||.|..||..|  |. || .|||||||||||||.|.|..|..|||||||.|.|....||.||||.|||..||.||||.||..|||.|
vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr
0050432 (Phosphotyrosine protein) phosphatases II 1022-1314 2.4e-85 281.9 In-house 25-301 (308) alignment 
Range on Protein: 1022-1314
Range on HMM: 25-301/308.0
KHPRDARRKILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELssshHNSGGYINASRVKVPVAGELLHYIAAQGPMENT
|.. .   |.|||.|  |....|.|..... .   .....||||...||.||.|||. .|| |    ... .||||| |.... .   ..||.|||..||
klsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpnt

VQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHG
| |.|||||| ...|| ||||| |.|.|||..|||. .  .... |.|.|.|        . |..  |.|... .|| |||.|..| .||..|.|...  
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplel..gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

FLSFLEEFQSVCRHansmnevevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
.|.|||. ......          .| .|||||||||||.....|.... ||.. ........  ||.||. ||||. || |.|.||.  ||.
lldflelvrkslpg..........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 1039-1312 1.8e-81 269.1 In-house 23-286 (288) alignment 
Range on Protein: 1039-1312
Range on HMM: 23-286/288.0
GQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVWESGTQVI
 ... |.|..... .   .....||||...||..|.|||...|| ||. .  ....||||| ....  .    .||.|||..||| |.|||||| ...||
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvI

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHV----PSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVC
 ||||| |.|.|||..|||.     ... ..|...|        . |..  |.....    ..|| |||.|..| .||..|.||..  .|.||.......
vmltklvelgrekcaqYwpl.....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

RhansmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
.          |.| .|||||||||||.....|.... ||...........  ||.||. ||||. || |||.||.  |
a........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1030-1316 2.1e-80 265.5 In-house 4-281 (297) alignment 
Range on Protein: 1030-1316
Range on HMM: 4-281/297.0
KILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELsssHHNSGGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMV
|.|||.|   .. .|.|....      .....||||...||.||.|||...|| |   .... .||||| |  .. .   ..||.|||..||| |.||||
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmv

WESGTQVIAMLTKLKEDGKEKCFKYWPDCtspKKNTAEFGPFRVIAQFSND--SGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLE
|| ...|| |||.| |.|.|||..|||.    . .. ..|.|.|  .  .   .. |..  |.. .. .||.|||.|..| .||  |.|...  .|.|.|
weqnvtvIvmltelvelgrekcaqywple...egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

EFQSVCRHANSMnevevgPPPIVHCSAGVGRTGVLLLVDIMISSLE---HNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNTR
....|.....|       .| .|||||||||.|.....|.|.. ||   ......|....  ||.||. .|||..|| |.| ||.. ||...
lvrkvlkllpsg......gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
subfamily_PTPN3_pd Subfamily PTPN3 1031-1313 4.5e-80 263.6 In-house 7-276 (280) alignment 
Range on Protein: 1031-1313
Range on HMM: 7-276/280.0
ILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHnsgGYINASRVKVPVAG--ELLHYIAAQGPMENTVQDWWRM
 |...|. |.|....||. .|..|  . ....|||.|.||..|.|||.. ||.|..|.     ||||. |.. . .     .|||.|||...|..|.|.|
llkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqm

VWESGTQVIAMLTKLKEDGKEKCFKYWPDctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEE
|||  ...| ||| | |.|. || .|||.    .... |.| |.|  . .. .  |..  |.|..  . |.|.. .||| .||..| ||| . ||.|.|.
vweqksslivmlttlverGrvkChqyWPe....tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefver

FQSVCrhansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
 ...              | .||||||.||||||.|... .. .|..|........  .|.||. .|||..||.|| .|...  .
vrklr........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
0046845 (Phosphotyrosine protein) phosphatases II 1042-1314 7.6e-79 260.3 In-house 3-276 (284) alignment 
Range on Protein: 1042-1314
Range on HMM: 3-276/284.0
FTEYEQITKKREGA--VCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH--NSGGYINASRVKVPVA---GELLHYIAAQGPMENTVQDWWRMVWESGT
. |.|....        .....||||.|.||.||.|||...|| |.| ..  ....||||| |...         ..||.|||..||| |.|||||| ..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

QVIAMLTKLKEDGKEKCFKYWPDCtspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVC
.|| |||.| |.|.|||..|||.     ... ..|.|.|     .  ..|..  |.|...  .|| |||.|..| .||..|.|...  .|.||.. ....
rvIVmltelvengrekcaqYwple....gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

RHansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNE---EINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
..      .. |.| .|||||||||||.....|.... ||...   ........  ||.||. ||||. || |||.||.  ||.
en......lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 1031-1310 9.3e-79 260.0 In-house 4-270 (273) alignment 
Range on Protein: 1031-1310
Range on HMM: 4-270/273.0
ILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELsssHHNSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVW
.|||.|  .... |.|....  .   .....|||| ..||.||.|||...|| |   .... .||||| |...  .    .||.|||..||| |.|||||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvw

ESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQ
| ...|| |||.| |.|.|||..|||.      .. ..|.|.|     .  ..|..  |.|... .|| |||.|..| .||..|.|...  .|.|.|. .
eqnvrviVmLtelvelgrekcaqYwplegge..lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

SVCRHANSMnevevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.......|       .| .|||||||||||.....|.... ||.. ...... .  ||.||. ||||. || |.|.||. 
kalealpsn......gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 1039-1314 9.5e-76 250.4 In-house 18-278 (317) alignment 
Range on Protein: 1039-1314
Range on HMM: 18-278/317.0
GQVFTEYEQITKKREGaVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVI
...  |.|.. .      . ...|||| ..||..|.|||...|| ||.    .. .||||| |..|   .  ..||.|||..||| |.|||||| |..||
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgp..nlkrkfIatqgPlpntvedFwrmvweqgvtvi

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhan
 |||.|.|.|.|||..|||.     ..| ..|.|.|  .     . ..   |.. .  ..|.|||.|..| .|| .|.|..   .|.|||. .....   
vmLteleelgrekcaqYwpl.....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...

smnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
     . | | .|||||||||||.......|.. ||......... .  ||.||. .||| .|| |.|.||.. ||.
.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
DSPc_SM00195 1041-1311 1.6e-75 249.2 In-house 2-261 (263) alignment 
Range on Protein: 1041-1311
Range on HMM: 2-261/263.0
VFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
. .|.|.. ....   . ... ..|.|.||.|..|||.. ||.|..... ..  ||||. .|..   .  .|||.|||...||.|.|||||| ....|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTKLKEDGKEKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSG-CYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHAns
||. .|.||||| .|||.     ... .|| ..|  .  .     .|.  |.|..    |.|.| ..||..||..|.||. . .|..|.....  ..   
lteeeengkekcdrywpees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

mnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
       .| .|||||||||||.....||..|.||......| ...  ||.||. ||||  ||.|.|.|... 
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1041-1311 1.6e-75 249.2 In-house 2-261 (263) alignment 
Range on Protein: 1041-1311
Range on HMM: 2-261/263.0
VFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
. .|.|.. ....   . ... ..|.|.||.|..|||.. ||.|..... ..  ||||. .|..   .  .|||.|||...||.|.|||||| ....|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTKLKEDGKEKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSG-CYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHAns
||. .|.||||| .|||.     ... .|| ..|  .  .     .|.  |.|..    |.|.| ..||..||..|.||. . .|..|.....  ..   
lteeeengkekcdrywpees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

mnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
       .| .|||||||||||.....||..|.||......| ...  ||.||. ||||  ||.|.|.|... 
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRD_pd Subfamily PTPRD 1039-1313 2.1e-74 246.2 In-house 23-282 (564) alignment 
Range on Protein: 1039-1313
Range on HMM: 23-282/564.0
GQVFTEYEQITKKrEGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQVI
 ....||..|... .   . ... |.| ..||......|. .|| ||. . ..   ||||| ..     .  .|||.|||...|..|.||||||  ...|
lkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnssti

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhan
 |||||.| ||.|| ||||.     |.|...| . |  . ...   |.   ..|..  | |.|.| . .. .||..| |.   ..|..... ... .   
VmltkleEkgkvkchkYWPe.....kgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...

smnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
     .   | .|||||||||||. . .|.|.  ..... ..| ...  ||.||  ||||  || |...|. . |.
.....pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0039614 (Phosphotyrosine protein) phosphatases II 1030-1314 3.6e-73 241.9 In-house 23-291 (297) alignment 
Range on Protein: 1030-1314
Range on HMM: 23-291/297.0
KILEKQLREGQVFTEYEQITKKREGavCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH--NSGGYINASRVKVPVA-GEllHYIAAQGPMENTVQDWW
. |||..  .....|.|.. .  .   .....||||...||.||.|||...|| |..  .  ..  ||||| |...   .   ..||.|||...|| |.|
lllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatqgPlpetvedFw

RMVWESGTQVIAMLTKLKEDGKeKCFKYWPDCTSpkkntaEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFL
||||| |..|| |||||.|.|. ||..|||. ..      ..|.|.|        . |..  |....  .|| |||.|.|| .||  |.|...  .|.||
rmvweqgvtvivmLtklvelgr.kcaqywpeegg......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

EEFQSVCRHAnsmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
|. .......      . | | .|||||||||||.... ..|.. ||.. ...... .  ||.||. .||| .|| |.|.||.. ||.
elvrealael......pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0045450 (Phosphotyrosine protein) phosphatases II 1041-1311 3.8e-72 238.9 In-house 29-303 (307) alignment 
Range on Protein: 1041-1311
Range on HMM: 29-303/307.0
VFTEYEQITKKRE--GAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH--NSGGYINASRVKV------PVAGELLHYIAAQGPMENTVQDWWRMVW
.. |.|.. .        .....|||| ..||.||.|||...|| ||| ..  ....||||| |.|      ..    ...||.|||...|| |.|||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

ESGTQVIAMLTKLKEDGKEKCFKYWPDCtspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHV-PSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEF
| |..|| |||.|.|.|.|||..||||     . . ..|.|.|     .  . |.   |.. .  ..|| |||.|..| .||..|.|...  .|.|.|| 
eqgvtvivmltelvelgrekcaqywPde....geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

QSVCRHansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE---INIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
......         | | .|||||||||||.... ..|.. ||....   ..... .  ||.||. .||. .|| |.|.||.. 
rkalee......lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 1040-1309 7.6e-72 237.4 In-house 21-274 (278) alignment 
Range on Protein: 1040-1309
Range on HMM: 21-274/278.0
QVFTEYEQITKKREgAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIA
 .  |.|....      .....||||...||.||.|||. .|| ||. . ... .||||| |  ..     ..||.|||...|| |.|||||| |...| 
llllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvttiv

MLTKLKEDGKEKCFKYWPdctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhans
|||.|.|.|..||..|||      ... ..|.|.|  .  .  . |..  |.. .  .|| |||.|..| .|| .|.|...  .|.||........    
mLtelvelgrvkcaqYwp......ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale....

mnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
      . | .|||||||||||.......... ||.. ...... .  ||.||. .|||  || |.|.||.
....dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPN6_pd Subfamily PTPN6 1033-1315 2.3e-70 232.0 In-house 20-300 (306) alignment 
Range on Protein: 1033-1315
Range on HMM: 20-300/306.0
EKQLREGQVFTEYEQITKKREG--AVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVW
|..|    .  |.|.. .. .        .. ||| ..||.| .||... || |....     ||||. .|  | |.  .|||.|| .|.||.|.|||||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

ESGTQVIAMLTKLKEDGKEKCFKYWPDctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEf
.  ..|| |.||  | ||||| .||||    .... |.|  .|    ...   ||   |.. .   ..|.|.|.......||..|.| |   .|.|||. 
qensrvivmttkevErgkekCarYWPd....eeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled.

qsVCRHANSMNEVEVGPpPIVHCSAGVGRTGVLLLVDIMISSLEHN---EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNT
  | |......| | ||  .||||||.|||| ....||... .|..    .|.| |.. ..|.||  .|||  || |||||. . ....
..vnrkqeeleeaeagp.ivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
0045098 (Phosphotyrosine protein) phosphatases II 1038-1313 2.4e-70 232.4 In-house 6-273 (278) alignment 
Range on Protein: 1038-1313
Range on HMM: 6-273/278.0
EGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVElssshhnsgGYINASRVKVPvaGelLHYIAAQGPMENTVQDWWRMVWESGTQVI
......|.|..        .... ...|...||.||.|||. .||          .||||| ....  .   ..||.|||...||.|.|||.|| |..||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..p..kkfIatqgPlpstvadfwrmlwelgitvi

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHV----PSGEQRTVWHLQYNDWPNQGCPDDV--HGFLSFLEEFQS
 |||.|.|.|.|||..|||.     ... ..|.|.|  .     ..|..  |.....    ...|.|.|.||.|  ||  |.|..     ||..||. ..
vmltelvelgrekcaqywpe.....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefire

VCRHANSMNEVE-----VGPPPIVHCSAGVGRTGVLLLVDIMISSLehNEEINIPKMMGILRQQRML-MVQTVGQYTFVYKALIQSLK
......|. ...      | | .|||||||||||.| ....|.. |  .. .....    ||.||.  .||. .|| |.|..|.. |.
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN13_pd Subfamily PTPN13 1031-1314 3.9e-70 231.2 In-house 3-271 (273) alignment 
Range on Protein: 1031-1314
Range on HMM: 3-271/273.0
ILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSsshhNSGGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVW
 |.|.| ..|   |.... . .    | ..|  || ..||...||||.. ||.|.    ..||||||| .||||  .  .|||.|||. .||.| |.|||
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvw

ESGTQVIAMLTKLKEDGKEKCFKYWPDCTspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQ
|  ..||||.|. ||.|| || .|||. .  .|..   . ..|     ..   .  . |..... ||| | | ||.. .||. | |     .| |. | .
eqkaeviamvtlekekgkvkchrywPesk..nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr

SVCRHANsmnevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
.. ..|          | .||||||.||.|.|. .|...  .|...|... ...  ||.||  .|||  || |||||... ||.
rlqtdag.........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
Y_phosphatase Protein-tyrosine phosphatase 1065-1309 1e-68 226.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 1065-1309
Range on HMM: 1-234/235.0
NVSRNRFKDVLPYEDCRVELSSSHHNSGgYINASRVKVPVAgeLLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPdctSPKKN
| ..||.||.|||.. ||.|..| ..|  ||||. ||        ..||.|||...|..|.|||||.  ..||.|||.|.| |.||| .|||   . ...
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp...eeeee

TAEFGPFRVIAQ--FSNDSGCYITSGLTLRHVPSG-EQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCrhansmneVEVGPPPIVHCSAGVGRTGV
. ..| ..|  .   ..|.  |... |.|..  .  |.|.|..|.|..||..|.|......|........           .   | .|||||||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgt

LLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
....||....||..||... ...  ||.||. |||.. || |.|||..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1065-1309 1e-68 226.6 In-house 1-234 (235) alignment 
Range on Protein: 1065-1309
Range on HMM: 1-234/235.0
NVSRNRFKDVLPYEDCRVELSSSHHNSGgYINASRVKVPVAgeLLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPdctSPKKN
| ..||.||.|||.. ||.|..| ..|  ||||. ||        ..||.|||...|..|.|||||.  ..||.|||.|.| |.||| .|||   . ...
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp...eeeee

TAEFGPFRVIAQ--FSNDSGCYITSGLTLRHVPSG-EQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCrhansmneVEVGPPPIVHCSAGVGRTGV
. ..| ..|  .   ..|.  |... |.|..  .  |.|.|..|.|..||..|.|......|........           .   | .|||||||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgt

LLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
....||....||..||... ...  ||.||. |||.. || |.|||..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0040439 (Phosphotyrosine protein) phosphatases II 1057-1313 3.3e-68 225.3 In-house 3-247 (249) alignment 
Range on Protein: 1057-1313
Range on HMM: 3-247/249.0
CYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYW
.....||||...||..|.|||. .|| ||. . .. ..||||| ....  .   ..||.|||...|| |.|||.|| | .|| |||.|.| |.|||..||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikr..rfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHAnsmnevEVGPPPIVHCSAG
|.     ... |.| |.|     . .. |..  |.| ..  || |||.|.|| ||| .|.|...  .|.|.|. .......      . | | .||||||
pl.....ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel......pkggpvlVHCsaG

VGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|||||.... ..|.. ||.. .....  .  ||.||. .||. .|| |.|.||.. |.
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1039-1313 1.5e-66 219.7 In-house 18-281 (318) alignment 
Range on Protein: 1039-1313
Range on HMM: 18-281/318.0
G--QVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSG-GYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQ
|  ....|||......| .  . |  | |  .||. ..|.|...||.|.  . . |  ||||. .      .   |||||.|. .|..|.|||||| ...
GelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidG..yrrkkayiaaqaPlpetieDfWrmvWeqnsa

VIAMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVcrh
|| |||...| ||.|. .|||.     |.. ..|  .| .. . ... |.   .....  . |.|.|   .| .||..| |... ..|... . ...   
vivmltqeeergkakvhryWPs.....kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska...

ansmNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
    .. .   | .|||||||||||| . |||..  ..... ... ...  ||.|| |||||  ||.|.|..|.. |.
....qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
0037934 (Phosphotyrosine protein) phosphatases II 1057-1310 7.5e-66 217.4 In-house 2-240 (243) alignment 
Range on Protein: 1057-1310
Range on HMM: 2-240/243.0
CYTSKLPENVSRNRFKDVLPYEDCRVELssshhNSGGYINASRVKVPvaGellHYIAAQGPMENTVQD----WWRMVWESGTQVIAMLTKLKEDGKEKCF
.....||||.|.||..|.|||.. || |     ....||||. ..|.  .   ..|| |||...||.|    .|||.|| |..|| |||.|.| |.|||.
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt..p...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPdctspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMNEVEVGPPPIVH
.|||       .. ..|.|.|    ..  . |.   |.|.... ....|.|.|..|  || .|.||..  .|.||.| ..... ..|..    | | .||
qywp.......gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSAGVGRTGVLLLVDIMISSLehneEINIPKMMGILRQQRML-MVQTVGQYTFVYKALIQ
|||||||||.|.. ..|.. |    .... . .  ||.||.  .||| .|| |.|.||..
CsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 1040-1314 1e-65 216.7 In-house 26-287 (293) alignment 
Range on Protein: 1040-1314
Range on HMM: 26-287/293.0
QVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIA
..  |||.. .  .   . ...|..| ..||....|||.  ||.|.. ... .  ||||. .  |      ..||.|||. .||.| ||||||. ...| 
rfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi..pgynsprefiatqGPlpetvddfWrmvwekkssiiv

MLTKLKEDGKEKCFKYWPDCtspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANS
|||.| | ||.|| .|||.     ...  .|  .|  . ...   ...  |....  . |.|.| ....  ||. | |.. . .|.|....... ....|
mltqlvekgkvkCeeYWPad....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektas

MNevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
..      | .|||||||||||... .| .....|... ..|  ..  ||..|.|.|||. || |....... |..
kr......PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0042113 (Phosphotyrosine protein) phosphatases II 1058-1312 1.2e-65 216.6 In-house 2-243 (245) alignment 
Range on Protein: 1058-1312
Range on HMM: 2-243/245.0
YTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWP
 ...||||...||..|.|||...|| ||.  ..   .||||| |  ..     ..||.|||...||.|.|||.|| | ..| |||.. |.|..||..|||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

DctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHansmnevEVGPPPIVHCSAGV
.     ... ..| |.|     .  . |..  |.. .....|.|.|.|..| .|| .|.||..  .|.|||. .....          . | .|||||||
l.....gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......dsngpvlVHCsaGv

GRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
||||.......|.. ||.. ...... .  ||.||. .||| .|| |.|.||.. |
gRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 1037-1310 6.8e-65 214.0 In-house 14-288 (297) alignment 
Range on Protein: 1037-1310
Range on HMM: 14-288/297.0
REGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSS-HHNSGGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQ
..  .  ||..| ..      ..|||. |...||..||| |.. || |..  ...   ||||. |      .   .||.|||...||.|.||||||. . 
gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvWeqevl

VIAMLTKLKEDGKEKCFKYWPDCtspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSV---
|| | |.. | |. || .|||.    ....|||| ..|     . .  | .. |....|  .|.|.| | |.  ||. | |.. . .| .||. ..    
vivmttrvvergrlkcgqyWple...eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

--CRHANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
     ... .    ||| .||||||.|||| .  .|| .| ||. . ... . .  ||.||  ..||  ||.| |.|...
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1041-1314 8.6e-64 210.3 In-house 17-278 (281) alignment 
Range on Protein: 1041-1314
Range on HMM: 17-278/281.0
VFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
  .|||....   . .   || .||| .||....  |.  ||...  .....  ||||. |.  . ||  .|||.|||. ......|.||||   ..|.|
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykge.keyiatqgPvPaslvafWqmvweqkvsaivm

LTKLKEDGKEKCFKYWPDCTSpkknTAEFGPFRVIAQFSNDSGCYITSGLTLrHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSm
.|.  | || || .|||| .|    . ..| ..|  . ....  ||.  ..| .  |||.|.| .|.|  ||..| |.. . .|.| .| ... .. .  
vtreieagklkChrYWPddns....elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.

nevevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHN-EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
       | ..||||||||||. . .| .....|.. ||...  ..  ||..|.|||||| ||.|||||... |..
......aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1061-1311 8.5e-63 206.8 In-house 13-263 (270) alignment 
Range on Protein: 1061-1311
Range on HMM: 13-263/270.0
KLPE---NVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWP
.|||   .   ||..|.||    || |.. ...|   ||||  |.  . ||  .||||.||...|....|||.||. .. |.|.|.|.|.|..|| .|||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr.GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

DcTSPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRhvPSGEQRTVWHLQYNDWPNQGCPDDVHGFL---SFLEEFQSVCRHANSMNEVEvgpPPIVHCS
   . .| . |.|  .|.|. .. .  ||.  |.|.   .||.| . | .||.||..| | .  . |   . |. .. | |. ..... |   | .||||
a.epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae...PllvHcs

AGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
|||||||.|...||..  ||....... ...  ||..|| .||.. ||.|.|||... 
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_PTPN12_pd Subfamily PTPN12 1056-1313 1.9e-62 205.8 In-house 31-278 (290) alignment 
Range on Protein: 1056-1313
Range on HMM: 31-278/290.0
VCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKY
   ... .||| .||.||.|||.  |||||  ...   .||||. .| .   . |.|||||||. .|..|.|||.||  .... |. .. | || || .|
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv..egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPDCTspkKNTAEFGPFRVIAQFSNDSG-CYITSGLTLRHVpsGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhansmnevEVGPPPIVHCS
||. .   ... |||.|.|  .  .     ..   |....   .|.|.|  ..|..||..|.|  ..  |...|..... .        .   | .||||
Wpeeg...eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe........sedaPlvvhCs

AGVGRTGVLLLVDIMISSLEHN---EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|||||||... .|.. . |...   ||... ...  ||.||  .|||  ||..||||... ..
aGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1039-1310 2.2e-62 205.7 In-house 21-277 (288) alignment 
Range on Protein: 1039-1310
Range on HMM: 21-277/288.0
GQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVI
 ..  ||.....  .     ...|..| ..||....|||.  ||.|    . ..  ||||| ...   ..  .|||.|||. .||.|.|..|.|  |. |
tgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg..ekkkkkyiatqgPladtvndfWelvyenktsti

AMLTKLKEDGKEKCFKYWPDCTSPKkntaEFGPFRVIAQFSNDSGCYITSGLTLRhvPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvcrHAN
.|||.| |.||.|| .||||   ||    ..| . |... |.. . ...  | |    ....... ..||  ||..| |.. . .| .|.  .     ||
vmltelveggktkCeeYWPdadkpk....nyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvk....van

SMNevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
. .      | ||||||||||||. . .| .|  .|... |..  ..  ||.||.|.|||. || |.|..|..
qad....tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1031-1313 2.4e-60 199.3 In-house 13-284 (305) alignment 
Range on Protein: 1031-1313
Range on HMM: 13-284/305.0
ILEKQLREGQVF-TEYEQITKKreGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRM
| |..  . . . ..|......  .  .   |  .|...||.|.. ...| |. |. ....    ||||| |.     .  .||.||||..|||.|.||.
ikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk..kyivaqgPlkntvadfWrl

VWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLE
..|  ...| |||||.|.||.|| .|||. ..   .. |||.| |. . ..    ||.  |..     . |.||| ..|  |||..| |.    .||...
iveekvstivmltklveggkdkCrqYWpeskt...ekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

EFQSvcrHANSMNEVevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
. |    . .. ..|    | .|||||||||||| . |||..  |.. |.... ...  ||..|| ||||  ||.|.. || . ..
rvqk...dqkkdkgv....pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1061-1315 1.9e-59 196.0 In-house 24-271 (274) alignment 
Range on Protein: 1061-1315
Range on HMM: 24-271/274.0
KLPENVSRNRFKDVLPYEDCRVELSS--SHHNSGGYINASRVKVPvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDC
... . ..||.|..|| |  || |.|  |...   ||||  .| .  .|   |.|.|||. |||.|.|||...  .||| |||||||  ..|| .|.|| 
dvfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

TSPkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSgeQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFqsvcRHANSMNEVEVGPPpIVHCSAGVGR
..  . . ..| . .  .  ..   |    |.|... .  .|.| |  | |||..  |||.. .|....|     ..... .. ...|  .||||||.||
edy.eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvlev....eesreeenaklapv.vvhCsaGiGr

TGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNT
||. . ..| .  |.... ... |..  ||..|  ||||  || ....||.. ||..
tGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_PTPN1_pd Subfamily PTPN1 1045-1313 2.9e-59 195.2 In-house 12-272 (290) alignment 
Range on Protein: 1045-1313
Range on HMM: 12-272/290.0
YEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHnsgGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLK
|..|.|. .   . ..||||| ..||..|| ||. .|..| ...     ||||| |... |    .|| .|||. |||. .|.||||  .. . || |. 
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakr..syiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EDGKEKCFKYWPDCTSPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEfqsvCRHANSMNEvEV
| .. ||..|||   . |. . |   ..|     ...  |. . | |  . . | |.. |  |  ||. | |.    ||.|| .    .|.. |... .|
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfk....vresGslss.dv

GPpPIVHCSAGVGRTGVLLLVDIMISSLEHNEE---INIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|| ...|||||.||.| . ||| ..  .|....   ..| |..  ||..|. ..||  |  | | |...  |
Gp.avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Ptp69D_pd Subfamily Ptp69D 1040-1313 1.8e-58 193.1 In-house 23-287 (307) alignment 
Range on Protein: 1040-1313
Range on HMM: 23-287/307.0
QVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIA
 .  |||.. ..     . .|.  ||  .||..|. .... || |.    ...  ||||| .|     |  ..||||.|.|.|..|.|||..|   ..| 
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikg..ykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTKLKEDGKEKCFKYWP-DctspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-----SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSV
||..|.|  ..|| |||| .      .. ..|   |    ..  . ||   | . ..        ..| |   .|. |..   |.  .| | ..|. ...
mlsnlteknrkkcakYWpie......devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

CRHAnsmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
 ..           | .|||||||||.|... .|...  |. .....| ...  ||.|| |.||   ||.|.|.||..  .
ykln........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1041-1313 2.8e-57 189.2 In-house 25-284 (319) alignment 
Range on Protein: 1041-1313
Range on HMM: 25-284/319.0
VFTEYEQITKKREGaVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
.  |.... .  .    .... .|| ..||....|.|. .|| ||. .  ..  ||||| .      |   .||.|.|.|||..|.|||||| .. .. |
lekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg..yqerekfiatqaPlentiedfWrmvWeeessivvm

LTKLKEDGKEKCFKYWPdctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSG-EQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvcrhaNS
||||.| .| |. ||||     ..|  |.| . |  .  .    || . |.|..  |  | |.| | ||..||... |..  . | .|.. .      .|
ltklveklkvklkkywp.....eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir......ks

MNEVEVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
... . | | .|||||||||||  . .|.|.  ..... ... ...  || || .|||.  ||.|.|.||.. ..
rektqsg.PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1042-1313 6.6e-57 188.0 In-house 33-291 (298) alignment 
Range on Protein: 1042-1313
Range on HMM: 33-291/298.0
FTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAML
| . ...... | .    .. ||| ..||. |..... .|| |.. .  . . ||||| ..     .   .||.|.|...||.|.||||.|   ..| ||
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVml

TKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMn
|.|.| .| |. |||||     ......| ..|  . ... . .|.  |.. .  . ..|.| .|..  ||..| |   .  | .|.. .   ..|    
tnleeldktkyhkywPd.....egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk.

evevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
      | ||.|||||||.|    .| ..  ..... . . ... .||..|. .|||  ||.|.|.| .. |.
......pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN23_pd Subfamily PTPN23 1029-1314 8.4e-57 187.2 In-house 8-282 (288) alignment 
Range on Protein: 1029-1314
Range on HMM: 8-282/288.0
RKILEKQLREGQVFTEYEQITKKReGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSsshHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRM
|| |. .   ...| | ||  .|       ..    ....||..|.|||.  || |     .   ||||| ||  ..    ..||.|.|...|..|.|.|
rkmldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkd.lspgcPdfiatqaPlqstlnDFWlm

VWESGTQVIAMLTKLKEDGKEKCFKYWPDctsPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEE
|.|  ..|| ||.. .| ||.|. .|||     | .| .||...|  .  .... ..   |.|.. .. . ..| |||.. ||. | |.  . .| ||.|
vyeqkssviVmllskeelgkpkvdrYwPe...dkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

FQSVCRHANSMNEVevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE-INIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
 .|  .. .   ..    | .||||||||||||. ||   .  ||...  ..|....  ||.||  |||.. |. |.|.| ..  ..
vesayeavqrkskt....PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPRG_pd Subfamily PTPRG 1043-1313 6.7e-56 184.7 In-house 23-288 (563) alignment 
Range on Protein: 1043-1313
Range on HMM: 23-288/563.0
TEYE--QITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSG--GYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIA
 |.|  | . . .   . .|. |||  .||  ....|.  ||.||.   . .   ||||. ..    ..   .||.|||...|..|.|||.||  ...| 
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk..afiatqgplkdtfddFWrmiWeqnvaiiv

MLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQ----RTVWHLQYNDWPNQGCPDDVHGFLSFLEEFqsv
|.|.|.|.|..||. |||       .. ..| ..|  . ..   .| .  |....  .  ..|    ..| . .| .||..| |.     |.| .     
mitnlvergrrkcdvYWPk.....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks...

crhaNSMNEVEVGPpPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
    .  |. |.||  .|||||||||||... .| ..  ..... .|. ...  .| ||  .|||  ||.|...||.. ..
....saankaeaGP.ivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1043-1313 9.6e-56 183.8 In-house 11-296 (297) alignment 
Range on Protein: 1043-1313
Range on HMM: 11-296/297.0
TEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSgGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
.|.. . ....|    ..| .  . .||..|.| ..| || |  .  ..  ||||  |  |   . |.|| ||||...||.|.|..|.| . .||.|..|
aekdllldeargesfssakrnsslrknryrdilatddtrvkllrviter.dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

LKEDGKEKCFKYWPDCTSPKKNTAEFGpFRVIAQFSNDSGCYITSGLTLRHVpsGEQRTVWHLQYNDWPNQGCP---DDVHGF--------------LSF
|.|||..||. |||..   .......     ....|..    | . |.| .    |.| | | |.  ||. | |   .|.  |              |. 
lqedGrdkcapywpsvvqerlkagdvv.veflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlal

LEEFQSV-CRHANSMNEVE-VGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
.| | ..     .|..       . .|||||||||.||..| |.... | ..   ..  .. |||.||  .|||. |....|.| .. ||
vemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1061-1313 4.4e-55 181.9 In-house 47-285 (297) alignment 
Range on Protein: 1061-1313
Range on HMM: 47-285/297.0
KLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVPVAgellHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKeKCFKYWPDCT
.   | ...|.|..|||.  ||.| .  .. .  |.||| ||.       ..|. | ||..||.|.|.||..  ...|.||....|  | || .||.| .
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

SPKkntaeFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPD--DVHGFLSFLEEFQSVCRHANSmnevevGpPPIVHCSAGVG
. .     ||   |. .  ..   .|   |....  .  .| |   |. .||..  .   ... .| ...| . .  . ..      | | .|||.||||
vtt.....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae......g.PllvhclaGvG

RTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|||||| .| ...  ....|..| ...  |||.|. .|||  ||.|||.|... | 
rtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1061-1313 5.7e-54 178.0 In-house 5-243 (250) alignment 
Range on Protein: 1061-1313
Range on HMM: 5-243/250.0
KLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVPVaGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEkCFKYWPdct
| |.|  .||. |..... .|| | ...  .   ||||| ...   ..   .||.|||...|..|.||||.|  ...| |||.||| .|. . .|||   
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP...

spKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMnevevgpPPIVHCSAGVGRT
   ... ..|  .|    ..  . |..  | | .    ..|.| .|..  ||..| |.  .  | .|.. |.  ..|..        | ||.|||||||.
..vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna.......PvivqCsaGvgrs

GVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|  . .| ..  |.... ... |.. .||..|. .|..  || |||..... |.
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRA_pd Subfamily PTPRA 1044-1310 7.5e-54 177.8 In-house 37-293 (330) alignment 
Range on Protein: 1044-1310
Range on HMM: 37-293/330.0
EYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
|.. .   .  |.. ...  ||  .||. ..|||.  || ||  . ...  ||||| ..     |  ..|||||| |.||.|.|||.||  .. | |||.
efnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidG..ykekdkfiaaqGPkeetvedfwrmiweqksativmlte

LKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGE----QRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcrhans
|||  .||| .||||     . .  .|  ||  . .. .  |    . ....| .     .| |  . .. ||. | | .  | |..|.. ..       
lkerkeekcaqywPd.....eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk.......

MNEVEVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.|... | | .||||||||||| .. .| ..  .. .. ... ...  ||.||  ||||  ||.|.||.| .
lnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1065-1314 5.4e-53 174.8 In-house 43-280 (515) alignment 
Range on Protein: 1065-1314
Range on HMM: 43-280/515.0
NVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkk
| ..||.|..|||.  || |   . |    |.||| ..         |||.||| . .|.|.||.|..  .  |||.|||||. | || |||||  .   
nfkknryknilPydsvrvklevindnPhsdyfnasyips..fdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg...

NTAEFGPFRVIAQFSNDSGCYITSglTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcrHANSMNeVevgpPPIVHCSAGVGRTGVLL
.. .|| ..|     .  .  |    .|. . . . |||   ....||..| | .   .| .. | ..     . ..      | |.|||||||||||..
dsvkfGsikvelvsleactggikr..kltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka...dhgqyt.h....pliihcsaGvGrtGvvi

LVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK--N
 .| ...  .  . ... ... ..||.|. .|||  ||.|.| |. . |.  |
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1060-1315 1e-52 174.0 In-house 39-282 (315) alignment 
Range on Protein: 1060-1315
Range on HMM: 39-282/315.0
SKLPENVSRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDC
.. ..| ..||.|..||..  || |     .    ||||| .|     .   |||.||| . .|.|.||||... .  |.|.||..|. | || .|||| 
aretinfkknryknilPldsarvkleviddsPdsdyinasyiks..vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

tspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVcrhaNSMNEVEVgpppIVHCSAGVGR
   | ...||| ..|     .  .  ..  |..|.  | |.|||   |...||..| . ..  .| .. | ..     | ..|  .    .|||||||||
...kadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad....ngkkefsl....lvhcsaGvGr

TGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK--NT
|||.. .| ... ..... ... ... .||..|. .|||  .|.|.| |. . |.  ||
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1039-1313 6.6e-52 171.1 In-house 10-278 (287) alignment 
Range on Protein: 1039-1313
Range on HMM: 10-278/287.0
GQVFTEYEQITKKREGAVCYT--SKLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQV
 .|  |......  |..      ..   .|..||. ||||..| || ||   .    ||||  |      |   .||||||.  ||.|.||.|.|  . .
ddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytdde..afiaaqgPiaatvrdfwravletrsas

IAMLTKLKEDGKEKCFKYWPDCTSPKKntaeFGPFRVI-AQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRH
....|.  |... ||.||||.   | .     | . |.  .... .  | .  | | .. . | | |  |.. .||... .    |.. |  . .     
vitmtreveearlkcykywPerevPmr....vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

ANSMNEveVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
| . .|  || |..||...|.||.|.|| . ...| ||   .... ...  ||..|  .||.| |. ..|.||.   |
ardase..vG.PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPRK_pd Subfamily PTPRK 1044-1310 7.5e-52 171.1 In-house 27-275 (314) alignment 
Range on Protein: 1044-1310
Range on HMM: 27-275/314.0
EYEQITKKregavCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
||| . .        ..|  || ..||..|.|.|. .|| | . . . |  ||||. .         ..|..|||...||.|.||.|.. ..  | |||.
eyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalids..ykrpaafivtqgPlqetvkdfWrlvydencasivmlte

LKEDGKEKCFKYWPDctspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHansmn
|.| |. || ||||.      .|  .|...|    ..    ...  .....   .  |.|.| ..|.  ||. . |   .|.|... . ..   .     
lvevgrvkClkyWPe......dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.....

evEVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
  | | . .|||||| ||||. . .||..  .|... ... ...  ||.... ||.|  ||.|.| ....
..eaG.rivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1040-1310 4.6e-50 165.7 In-house 35-289 (319) alignment 
Range on Protein: 1040-1310
Range on HMM: 35-289/319.0
QVFTEYEQITKKR-EGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVI
..  |. ...|.  ..|    . |..|  .||. ..|...  .| |      .   ||||| |.     .   |||||||..||..|.|||.||. .  |
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd..kyiaaqGPldntladfWrmiweyncsti

AMLTklkedgKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHA
 .||      |.|| .|||      |   . . | |  .  ...  |.   . | .     ..| .    .  ||..| ||    .. ...  . . .. 
vllt......kdkcsqywpl.....kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

NSMNEVevgpppIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
|  ...      .|||||||||||| . .|.... ..... ... ...  |||||  .|| . || |.| ||..
nhrani......vvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1045-1310 4.7e-49 162.4 In-house 4-253 (284) alignment 
Range on Protein: 1045-1310
Range on HMM: 4-253/284.0
YEQITKK-REGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTk
. ...|.  .|.    . |..|  .||. ..|...  .| |      .   ||||| ..     .   |||.|||..||..|.|||.||. .  | .|| 
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd..kyiatqGPldntladfWrmiweyncstivllt.

lkedgKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMNE
     |.|| .|||      |   . . |.|  .  ..|  |.   . | .     ..|..    .  ||..| ||    .. ...  . . .. |  ..
.....kdkcsqywpl.....kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhran

VevgpppIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.      .|||||||||||| . .|.... ..... ... ...  |||||  .|| . || |.| ||..
i......vvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1049-1314 3.5e-47 155.6 In-house 30-285 (290) alignment 
Range on Protein: 1049-1314
Range on HMM: 30-285/290.0
TKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELS--SSHHN-SGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKE
 .  .    ..   ..|  .|||.....|.| |. |   |.|.. .  ||||. .|     |  .|||.|||..||. |.|...|.  . .| |||. .|
dsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg..ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniie

DGKEKCFKYWPDCtspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPS-GEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANsmNevev
.||.|| .||||      .|...|.|..  .  .    ||.  | ...  | |....| ..|   |...|   . .. |. .|| .   |.    |    
egkvkCqqYWpds.....dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..n....

gPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
  . .||||..|||..|.. ... |   . .  |.. ...  .|.|.. .|||| || .... ....|..
.tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRN_pd Subfamily PTPRN 1039-1312 2.2e-46 153.0 In-house 29-292 (297) alignment 
Range on Protein: 1039-1312
Range on HMM: 29-292/297.0
GQVFTEYEQITKK-REGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQV
 ..  |.| ...   | ... ..| ..||..|| |.||||.. ||.|.. . ...  ||||| .          |||.|||. .|| |.|.||||.|. |
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvv

IAMLTKLKEDGKEKCFKYWPDCTSPKKNTAEFgpfRVIAQFSnDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHA
| .||.|.|.| ..| .||||  |   .  |    .....    .  |.   . |. . . | |||  . .  ||..|.|   . .| |    .   |  
ivnltrleeegvkqckrywpdeGsevyhiyev...hlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

NSmnevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEH-NEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
 .        | .||||.|.||||| .|.|.... | .   ||.|   .  ||.||  .|.|  |. |...|... .
sc........pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1058-1311 4.8e-46 152.1 In-house 42-278 (315) alignment 
Range on Protein: 1058-1311
Range on HMM: 42-278/315.0
YTSKLPENVSRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWP
 ..|  ||. .||. ....|.  ||.|     ..   |.||. ..        .|||||||  ..|.|.||.|.|     | |||.| |. |.|. ||||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidG..ynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

DCtspkknTAEFGPFRVIaQFSNDSGCYITSgLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLeefqsvcRHANSMNEVEVgPPPIVHCSAGV
|          .|.. |  . |..    .|   ||  |   . |.|  |.|  ||. | |     .. .        |...  .. .|  . .|||||||
dk......kviyGkitvt.rkseevnteytv.rtlsvvfgdnirevvqlhytswpdmgvpkytiplmnli.......rtvkqhhtnsv.gaivvhcsaGv

GRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
|||| .. .| ..  .| .. |.. ...  .||.|. |||.. || |.|.||...
GrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1042-1314 1.2e-45 150.7 In-house 26-280 (287) alignment 
Range on Protein: 1042-1314
Range on HMM: 26-280/287.0
FTEYEQITKKREGAVCYTSklPENVSRNRFKDVLPYEDCRVELSSSHHNsggYINASRVKvpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLT
||  ||.|....      .  ..|  .||....|.... || |   |..   ||||. ..     |  ..|.|..|| ||....|.....   ..| ||.
ftvleqvtqredevthnia..sqnkdknRltqilvpdnyrvllkgehpd...yinavfid..gykekkafiiaesPmfntarnfWkliddrnvtaivmlc

KLKEDGKEKCFKYWPDCTSpkkntAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVC-RHANSm
..||. .|.|..|||. .|       .|....     . .  ||   | ...   .|....|   |. .|...|   .    |  .||      ...|. 
qekendeevcyqyWpeeks.....vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt.

nevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
       . .||||..|||..... ... |   . .  |.. ...   |.|.. .|||| ||.|........|. 
.......sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1042-1310 3.2e-45 149.2 In-house 12-265 (283) alignment 
Range on Protein: 1042-1310
Range on HMM: 12-265/283.0
FTEYEQITKKREGAVCYTSKlpENVSRNRFKDVLPYEDCRVELSSSHHnsgGYINASRVKVPVAG-ELLHYIAAQGPMENTVQDWWRMVWESGTQVIAML
.  .....     |.. ...  ||   ||.....|..  |||| |  .    ||||. . |     .   ||.||.|...||.|.|.||..     | ||
revlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TKLKEDGKEKCFKYWPdctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQR-TVWHLQYNDWPNQGCPDdvhgFLSFLEEFQSVCRHANSM
|||.|| ..|| .|||     |. . ..|.| |  .    |  .|   |.||.  | ..   . | |..|| . |        .  |  |  |    .  
tklqedlrikCsqyWP.....krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa....iinslvkfnkvislqtes

NEvevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI-Q
..     | .||||.|.|||.|.. .   .  .  .  ....... |.|.||| .||| .|| .|... . |
kk....gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1034-1312 3.9e-45 149.4 In-house 17-288 (325) alignment 
Range on Protein: 1034-1312
Range on HMM: 17-288/325.0
KQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMV--W
|. .. . |.   ...   .|    .. .|||...||||.|....  || | . .   |  ||||| ..  .  .   ..||| |. .|..| ||.|  |
kkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdv..flaaqaPltatindlWrlvldW

EsgTQVIAMLTKLkEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQ
.  . |. .| .| . ||..| .|||.  .   .. .||...|  .  ..   |.   | .. |  || |.|  .|.  |.. | .     ..|.|.  .
r..csvvvvlnel.dlgkdrcavywpkemg...ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

SVCRHANSmnEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
 |    ..  . .   | .||||||||||||.. .  ..  . .. ...| ...  ||..|  ||.|| ||...|.||.. .
avservta..ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1064-1309 1.2e-42 140.8 In-house 2-236 (237) alignment 
Range on Protein: 1064-1309
Range on HMM: 2-236/237.0
ENVSRNRFKDVLPYEDCRVELSSSHHNsGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
||  .||. ..  |. .|| |  .  .   ||||. .|  . |   .|||||||.|.. .|.|.|||.    || ||| | |  ..|| ||||.   |. 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

ntaeFGPFRVIAQFSNDSGCYITSG-LTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANsmneveVGPPPIVHCSAGVGRTGVL
    .| . |  .  ..   |     |. ...   | | ..  |.  ||..| |.    .| |  .     .| .         | |.||||||||||..
....ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvs......esgpwiihcsagvgrtgif

LLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
|..| |.   . .. ..| . .  . ..|  ..||  || |......
lvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0051429 (Phosphotyrosine protein) phosphatases II 1091-1312 5.6e-42 139.6 In-house 3-225 (272) alignment 
Range on Protein: 1091-1312
Range on HMM: 3-225/272.0
SGGYINASRVKVPvagelLH------YIAAQGPMENTVQDWWRMvWESGTQVIAMLTKLKEDGKEKCFKYWP-------DCTSPKKNTAEFGPFRVIAQF
 .|||||. |. .      .      .....||...|..|.||. .| |  .| .|... | |..||..|||       .. .    | ..| .||. ..
lsgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

SNDSGCYITSGLTLRHV-PSGEQRTVWHLQYNDWPNQGCPDDVhgFLSFLEEFQSvcrhansmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNE
     .||   |.|... . || |.|.||.| |||  | |..   .|..||....             | | .||||||..|||.. ......  .... 
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.............ggpvlvHCsaGkdRTGtvvallllllgvslet

EIN--------IPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
 ..        . . .  ||.||. .||| .|| |.|.||.. |
ivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1041-1313 1.7e-38 127.2 In-house 21-280 (439) alignment 
Range on Protein: 1041-1313
Range on HMM: 21-280/439.0
VFT-EYEQITKKREGAVCYTSKLPENV--SRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVWESGTQV
.|. ..|.|   .    | .| . ..   ..||.||| ...  || |          ||||  .|     .|  |||.||| ..|..|.||.|.|  |  
ifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl..yiatqgpkkettddfwrlviekktvt

IAMLTKLKEdgkekCFKYWPdctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLR--HVPSGEQRTVWHLQYNDWPNQGCPDDVhgflSFLEEFQsvcR
| |||.| |      .||||      .. . .|   | ..   .   |.  |. .   .  .  .||| ...|  ||..  | .     |.. .|    |
ivmltnlve.....sykywp.....sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa....shvldfl...r

HANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
  || |. |   | .||||||||||| .. .|| .  |  .....|  .. .||.||  |||.. || |.|.|... ..
ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1043-1313 2e-38 126.8 In-house 19-294 (301) alignment 
Range on Protein: 1043-1313
Range on HMM: 19-294/301.0
TEYEQITKKrEGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH---NSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
 .|...... |   |  .   ||   ||||.. .|.| |. |.  ..    .  ||||| ..     |  ..|||||||..|..|.||..|.  .. | |
eqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg..ysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LTKLKEDGKEKCFKYWPDCTSPKKNTAEF---------GPFRVIAQFS----NDSG-CYITSGLTLRHVPsgEQRTVWHLQYNDWPNQGCPDDVHGFLSF
.|.|||. |.||..|||...  ...  .|          |  || |..    . |.  || . .  ..    . ..|  ||  |||..|   . .  |  
vtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqv

LEEfqsVCRHANSMNevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
...   |    ....    | | .||||..|.|.||   |.| .     .  ... ..   .|.... .|.|  |||..|... . |.
idd...vihrqqkig....ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0041856 (Phosphotyrosine protein) phosphatases II 1065-1311 4e-38 126.2 In-house 1-170 (182) alignment 
Range on Protein: 1065-1311
Range on HMM: 1-170/182.0
NVSRNRFKDVLPYEDCRvelssshhnSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVWESGTQVIAMLTklkedgkekCFKYWPdctspkkn
|...||..|.|||.  |            ||||. .  .  .    .||.|||. .|| |..||..| | ..| .||         .. |||        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

taefgpfrviaqfsndsgcyitsgltlrhvpSGEQRTVWHLQYNDWPNQGCPDdVHGFLSFLEEFQSvcrhansmneveVGPPPIVHCSAGVGRTGVLLL
                               . ..|......|  ||  |.|| .. .|.|.|| ..             | | .|||||||||||.| .
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevle............eggpvlVHCsaGvgRtgtlva

VDIMISSlehneEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
 ..|..      ...... .  .|..|. ||.|  || |.. || . 
aylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_CG7180_pd Subfamily CG7180 1042-1309 4.2e-38 125.7 In-house 19-287 (296) alignment 
Range on Protein: 1042-1309
Range on HMM: 19-287/296.0
FTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAML
.    ..|.. |   | .    ||  .||  .|.||.  || |.. . ..   ||||. |   .  .   ||  ..|...||...||.|.. ... . .|
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk..eyivteapkketvdefWrlvydeeisavvvL

TKLKEDGKeKCFKYWPDCTspkknTAEFGPFRVIAQFSNDSGCYITSGLTLR----------HVPSGEQRTVWHLQYNDWPN-QGCPDDVHGFLSFLEEF
||  .  | .. .|||  .      ...|.. |    ..      .  . |           .  . |.|.| ..|.  |.  . .|    ... ...  
tktfdfak.mypsywpnks.....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

QSVCRHAnsmNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
... ...   .| ..  | .|..| |..|.|| | .|. .  .|..||... ...  ||..|  .|..| .| ..|  | 
rlwrekv...dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1065-1309 6.2e-38 125.3 In-house 7-237 (239) alignment 
Range on Protein: 1065-1309
Range on HMM: 7-237/239.0
NVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
| ..||. ... |.  || |   |      ||||| ..    |    |||.|| .| .  |.|||.|.    || ||| | |  |.||..|||| ||   
nkaknryanivtydhsrvvleklsndphsdyinasylrd.ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

NtaefgpFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFleefqsvcRHANSMNEVEVGPPPIVHCSAGVGRTGVLL
|      .||  . ..    ||   . . .|   |.| |.. ..  ||..| |.     | .        |.  . . .    | ..|||||||||| .|
n......lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl........rrkitkdslpgarpwvihcsagvgrtgafl

LVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..| |.   .... ..| . .  .|..|  ||||  || |.. |..
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1065-1309 8.4e-38 124.9 In-house 8-238 (239) alignment 
Range on Protein: 1065-1309
Range on HMM: 8-238/239.0
NVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
| ..||. ... |.  || |   |      ||||| ..    |    |||.|| .| .  |.|||.|.    || ||| | |  |.||..|||| ||   
nkaknryanivtydhsrvvleklsndphsdyinasylrd.ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

NtaefgpFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFleefqsvcRHANSMNEVEVGPPPIVHCSAGVGRTGVLL
|      .||  . ..    ||   . . .|   |.| |.. ..  ||..| |.     | .        |.  . . .    | ..|||||||||| .|
n......lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl........rrkitkdslpgarpwvihcsagvgrtgafl

LVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..| |.   .... ..| . .  .|..|  ||||  || |.. |..
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1059-1312 1.1e-37 124.4 In-house 39-236 (392) alignment 
Range on Protein: 1059-1312
Range on HMM: 39-236/392.0
TSKLPENVSRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVpVAGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGkekcfkywpd
... . |. .||.|..|||.  || |      .   |.||| ..  .  |   |||.|||   ...|.||||..  .  |||.|||||            
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.fdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

ctspkkntaefgpfrviaqfsndsgcyitsgltlrhvPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcRHAnsmnevEVGPPPIVHCSAGVG
                                        ..|||   .. .||... |  .  .| |..| ..   .       .   | |.|||||||
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevka..dfG......qythpliihcsagvg

RTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
||||.. .| ...  ..   ... ...  .|..|  ||||  ||.|.| |... |
rtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0036282 (Phosphotyrosine protein) phosphatases II 1093-1306 3e-36 120.1 In-house 3-164 (174) alignment 
Range on Protein: 1093-1306
Range on HMM: 3-164/174.0
GYINASRVKVPVAGEllHYIAAQGPMEntvqdWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDctspkkntaefgpfrviaqfsndsgcyitsgltlr
 ||||| ... .  .  ..|| |||..      |.|..| | ... ||...||.|..||. |||.                                   
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

hVPSGEQRTVWHLQYNDWPNQGCPDDVHgFLSFLEEFQSVCRHansmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEhNEEINIPKMMGILRQQRM
  .. . |......|  ||  |.||.   .|.|... .... .         | | .|||||||||||.| . ..|.  |. .  ... ...  ||.||.
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.......dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

LMVQTVGQYTFVYK
 |||| .|| |.|.
gmvqtpsQyrflyy
0049772 (Phosphotyrosine protein) phosphatases II 1056-1314 6.6e-35 116.7 In-house 37-282 (314) alignment 
Range on Protein: 1056-1314
Range on HMM: 37-282/314.0
VCYTSKLPENVSRNRFKDVLPYEdCRVELSSSHHNSGGYINASRVKVPvagelLHYIAAQGPMENTVQDW----------WRMV--WESGTQVIAM----
 .....|..| ..||..|.||.. .|| |.. .... .||||| |. .     | .||.|||.|.|| |           ||||  ..  . .| |    
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTKLKEDGkekcfK-----YWPDCTspkkntaefgpfrviaqfsndsgcyitsglT---LRHVPsgeQRTVWHLQYNDWPNqG
                 |..| . |           ....                                .    .. .   .|.. .. . ..|  |
vladelsrLdaAlgKtpllildgng.....neptaadlellk..............................eelydpelf...erlgikylripvpD.g

CPDDVHGFLSFLEEFQSVcrhansmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLehneEINIPKMMGILRQQRM-----LMVQTVGQYTFVYKALI
....   |..||| ....          . | | .|||.||.||||.......... |     ... . .  .|..|.      ....  || |...|| 
saplledfdeflefieea..........dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileall

QSLKN
. ||.
eylkf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1066-1312 5.3e-34 112.2 In-house 57-283 (290) alignment 
Range on Protein: 1066-1312
Range on HMM: 57-283/290.0
VSRNRFKDVLPYEDCRVELSSShhNSGGYINASRVKvpvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNT
. .||.|||   .  || |.      | |. |  ||    |    .| .||....|| | |||| . .. .| || .| |||| || .|.|.      ..
fkknrykdvvcndktrvilkdG..ydGdyvhanyvk....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG...ev

AEFGPFRVIAQFSNDSGCYI-TSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVhgfLSFLEEFQSVcRHANsmnevevGpPPIVHCSAGVGRTGVLLL
  || . |.   ..|    |    |..|.. || .  . ||.   ||..  .      |..|  .... |.|.       | | .||||||.|||| .  
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlril.rkas.......G.pvvvhcsaGiGrtGtfva

VDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
... .  | .  |... ...  ||. |.  ||   ||  . ..|..  
ievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
0043147 (Phosphotyrosine protein) phosphatases II 1091-1305 1.6e-33 111.2 In-house 4-154 (172) alignment 
Range on Protein: 1091-1305
Range on HMM: 4-154/172.0
SGGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLkedgkekcfkywpdctspkkntaefgpfrviaqfsndsgcyitsglt
.  ||||| .....     ..|| |||. ||. | |||..| | ..| .||.|                                               
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

lRHVPSGEQRTVWHLQYNDWPNQGCPdDVHGFLSFLEEFQSVCRHANsmnevevGPPPIVHCSAGVGRTGVLLLVDIMIsslehnEEINIPKMMGILRQQ
  . |....|......|  || .|.| .   .|.|||  ....   .       | | .|||||||||||.| . ..|.      . ... . .  .|..
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp.......ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrek

RMLMVQTVGQYTFVY
|. .||. .|| |.|
Rpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 1094-1312 5.1e-33 109.7 In-house 14-173 (176) alignment 
Range on Protein: 1094-1312
Range on HMM: 14-173/176.0
YINASRVKVPvagellHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKntaefgpfrviaqfsndsgcyitsgltlrh
||||. .  .      ..|| |||...|..|...|..| | ... .||...| |. ||. |||......                               
yinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

vpsgeqrtvwHLQYNDWPNQGCPDDvHGFLSFLEEFQSVCRHansmnevevGPPPIVHCSAGVGRTGVLLLVDIMISslehNEEINIPKMMGILRQQRM-
          . .. .||  |.||.   .|..||. ... ..         | | .||||||.||||.|.. .....    .  ... . .  .|.||. 
..........qylhlpwpDhgvpdl.elllellefirealke.........ggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRpl

LMVQTVGQYTFVYKALIQSL
 .||| .|| |.|... . |
gavqtpeQyrflyefellll
0049260 (Phosphotyrosine protein) phosphatases II 1109-1306 1.7e-32 107.6 In-house 9-144 (152) alignment 
Range on Protein: 1109-1306
Range on HMM: 9-144/152.0
LHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWpdctspkkntaefgpfrviaqfsndsgcyitsgltlrhvpsgeqrtvwHLQYN
 ..||.|||..||. |.|||..| | ..| |||.| |.||.|| .|.                                                . .. 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylhl

DWPNQGCPDDVHGFLSFLEEFQSVCRHANSmnevevgpPPIVHCSAGVGRTGVLLLVDIMIsslehnEEINIPKMMGILRQQRMLMVQTVGQYTFVYK
 ||  |.||.   .| .|.  .  ... .         | .|||||||||||.| . ..|.        ... . .  .|..|. .|.. ||. |.|.
pwpDhgvpdlsqlllflllfieklaldkgg........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
PTPc_DSPc_SM00012 1201-1309 5.3e-31 102.3 In-house 1-104 (105) alignment 
Range on Protein: 1201-1309
Range on HMM: 1-104/105.0
TVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHN-EEINIPKMMGILRQQRMLMVQTVG
|| |..|..||..|.|.... .|..|...... ....|      ..| .|||||||||||.. ..||....||.. .|..| ...  ||.||. ||||  
tvkhyhytgwpdhgvPeesdsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

QYTFVYKALI
|| |.|.||.
qylflyrall
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1046-1309 6.4e-31 102.0 In-house 18-266 (281) alignment 
Range on Protein: 1046-1309
Range on HMM: 18-266/281.0
EQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS--SHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKL
 ..       .| . . | |  .||. ..   .  ||.|      .||  || |  .. |.      || .||| ..|  |.|||.|.  |  | || ..
snlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkr..gyiltqgpkketradfwrmiwqenttaivmlcqf

KEDGKEKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvcrhANSMneve
 |  .||| .|.|  .   .   .|  . |  . |      .|. | | .   || | . |  ...||.   |.    .|  | . .     | |     
letnrekcaeyfprna...hcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkir.....arst....

vgpPPIVHCSAGVGRTGVLLLVDIMISSLE-HNEEINIPKMMGILRQ-QRMLMVQTVGQYTFVYKALI
   ||..||||||||.| |. |.| . |.  |    .| ...  ||   |   |||. || ...| |.
...ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1059-1312 6.6e-31 102.4 In-house 37-271 (288) alignment 
Range on Protein: 1059-1312
Range on HMM: 37-271/288.0
TSKLPENVSRNRFKDVLPYEDCRVELSsshHNSGGYINASRVKvpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPdc
 ..  .| .|.|....   . .|| ||    ..  ||.|  |    |    . | || |.. |..  |.|. ||. . | ||..| | ||||  .|.|  
idsfianptrdryenlprcditrvkls...ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP..

tSPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRT-VWHLQYNDWPNQGCPDDVHGFLSFLEEFqsvcrhaN---SmnevevgpPPIVHCSA
 | . ..| .| .  . . ...    . .  .||    ||..  | .| ...|...| |..   .| .|| .       .            | .||.||
.sklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqk........Pivvhssa

GVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
|||||| | |. |.. ||  .. . |....  ||..|.  .||  || .|.. . . |
GvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1041-1310 7.6e-31 102.2 In-house 18-275 (307) alignment 
Range on Protein: 1041-1310
Range on HMM: 18-275/307.0
VFTEYEQITKKREGAVCyTSKLPENVSRNRFKDVLPYEDCRVELSSSHhNSGGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQVIAML
.  |.....||   .|  .  .  |  .||..||   . .|. .  .   .  || |  . . .  .  ..|.||||.|||....| |. .   . . ||
lvdefrvlakktpegvt.veafsantdknryqdvkcqdkgrivvkfdg.lasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesviml

TKLKEDGKEKCFKYWPDCTSPKKNTAEFGPFRVIA-----QFSNDSGCYITSglTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEefqSVCRH
 |. | .| || .|||     |.  .| .    .|     ... |  .   .  ||. . ... ||. |||...||..|.|.   . . .||   .|  .
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvt..tlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle...avryd

ANsmnevevgpPPIVHCSAGVGRTGVLLLVDIMISS-LEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
 |         | .|||||||||.| .. . ..    ..  .  .. |..  ||.||   .||  || .... |..
tn.........pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_ptpA1_pd Subfamily ptpA1 1064-1274 9.5e-31 101.9 In-house 46-258 (418) alignment 
Range on Protein: 1064-1274
Range on HMM: 46-258/418.0
ENVSRNRFKDVLPYEDCRVELSSSHHNSG-GYINASRVKVPVAgelLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPK
 | |.||. ..|| .  ||.|   . . |  ||||  .         ..|..|||. ||. |.||||||   ..| ||..  |. . || .|||.    .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

K-----NTAE-FGPFRV-IAQFSNDSGCYITSgLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvCRHANSMNEVEVGPPPIVHCSAG
.     |  | || . | . .  .|    | .   .|    || | . . ||. ||..  ||  . |  .|       |. . .   .   | |||||||
qfsiygngnevfgtysvelveviqdpereiit.rnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit..nrqnqiipssdrnvpiivhcsag

VGRTGVLLLVDIMISSLEH
||||| .    ||.  |.|
vgrtgtfctavimmkkldh
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1065-1310 1.6e-30 100.8 In-house 55-287 (305) alignment 
Range on Protein: 1065-1310
Range on HMM: 55-287/305.0
NVSRNRFKDVLPYEDCRVELSSSHhnSGGYINASRVKVPVAGELlHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKN
....||..||   .   | |.        || |  | .|.  |   .|.||||...|....| || .   . | || |  | || || .||| .   |..
aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

TAEFGPFR-VI--AQFSNDSGCYITsglTLRHVPSGEQR-TVWHLQYNDWPNQGCPDDVhgfLSFLEEFqSVCRHANsmneVevgpPPIVHCSAGVGRTG
         |     .  |.   ||   .|.   ||.|. .| |||...||..| |      |. || . |  | ..    |    | .||||||.||||
lksgivvenvsgskpmerdaeiqit...llnltysgdqkmsvrhlqwtewpdrgvppck...ltslell.sairgsk....v....pivvhcsagigrtg

VLLLVDIMISSLEHNEEI-NIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
 .. .. ..  .  | .   .|...  ||.||   .|.  || |... ...
tivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1064-1317 2.6e-30 100.2 In-house 47-292 (305) alignment 
Range on Protein: 1064-1317
Range on HMM: 47-292/305.0
ENVSRNRFKDVLPYEDCRVELSSSHHNsgGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
..  .||.|||   .. || | ..      || |  |  |   .   .| .| |.|.|  |.| | ..   . | || .|.| | .||..|..    .. 
qeagknrykdvgcldnnrvklegpwph..eyihanyvstptnpk..rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

NTAEFGPF-------RVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEfqsvCRHANsmnevevGpPPIVHCSAGV
.  | |          |  .| .|.   .|    .   | ...| | |  ..|||..| |      | .||.    .| .        | | .||||||.
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek....arpsk.......g.pivvhcsagi

GRTGVLLLVDIMISSLEHNEEIN-IPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNTRL
|||| ..... ..  |   . |.   |..  .|.||   .||  || ||.. ... ... .|
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1043-1309 2e-29 97.2 In-house 31-287 (310) alignment 
Range on Protein: 1043-1309
Range on HMM: 31-287/310.0
TEYEQITKKREGAVCYTSkLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
 .| ..  |.. .. | .   ... .||. ||.  ...|| |   .   . || |  ||     .   .| .|||.. |. |.|||...  .. | .| |
kqyrkldakqdssltyea.ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs..tficsqgplqhtiidfwrmifqeraesilllck

LKEDGKEKCFKYWPDCTSpkknTAEFGPFRVIaQFSNDSG----CYITSGLTLRHVPSGEQRT------VWHLQYNDWPNQGCPDdvhgflsflEEFQSV
  |.|. ||  |||        |  .|  ||  ..|. |     | ..  .    ||  || .      |  ... .||..| ||         |  ..|
vgeegrpkcvgywpslgv....tetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtv

CRHanSMNEVEVGPpPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
 .    . .|  ||  .||||||..|..|.. ... |  |.. ..... ...  |...|.  .||  ||... .  |
pqr..llaqvrhgp.cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1042-1310 8.1e-29 95.4 In-house 12-257 (267) alignment 
Range on Protein: 1042-1310
Range on HMM: 12-257/267.0
FTEYEQITKKREGAVCYTSKlpENVSRNRFKDVLPYEDCRVELSSSHHNsggYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLT
| . ..|....    .. ..  .|  |||. |.|||.| || |. . ..   ||||| |.    ..  ..|. |.|..||. |.. .. . .  || .||
felikkisdtsstisqsiae..knqernrlddnlpyddtrvilrtkeee...yinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivllt

KLKEDgkeKCFKYWPDCTSPKKNTAEFGPFRVIAQFSNDSGcYITSGLTLRHVpSGeqRTVWHLQYNDWPNQGcpdDVHGFLSFLeefQSVCrhanSMNE
|  .|   .  ..||      |.  ..   . . .  ||    ||  | ..   |   . |    |. |  .    . . .|  |     .     . |.
kvftd...nirlfwPPkmgqakkyqdltvehslekeendyq.iitlelkfkne.sa..hnvtlyyykkwnint...nnkpylkpl...fgil....aknq

VEVGPPP-IVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.| | .| .|.||.||||.| .| .| ..  . ...  .| ...  .|.||. .|.|  .| .... | .
lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1069-1313 3.3e-27 90.0 In-house 47-277 (312) alignment 
Range on Protein: 1069-1313
Range on HMM: 47-277/312.0
NRFKDVLPYEDCRVELSSSHhNsgGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkknTAEF
||. ..  ..  |  |.    |   || |  ||.    |  .....|||.|||.  .|...   |.  | .|. . ||| ||| ||  |  .      ..
nrypniqcwdrgrftlagde.n..fyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg....fvdl

GPFRVIAQFS------NDSGCYITSGL-TLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLeefQSVCRHANsmnevevgpPPIVHCSAGVGRTGV
   || ...         |   ||  .  .    .|..  . | |.  ||..| || .   | .|    .| .  .         | | |||||||||| 
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll...savkkdkk.........pviahcsagvgrtgt

LLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
| |.. ||..| |    |. ... .||..|   |... || .. ..... | 
laliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_CG42327_pd Subfamily CG42327 1063-1233 9.1e-27 88.5 In-house 25-194 (319) alignment 
Range on Protein: 1063-1233
Range on HMM: 25-194/319.0
PE-NVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVPVAGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTS
|     ..|. .|.|  . || | . . ...  |..|| |. .   .  .||||| ..|..  |.||.|||  ..||  ||.| | | ..| .|.|   .
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddap.nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

pKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYnDWPNQGCPDDVHGFLSFLEEFQSVC
  .||  .| ..|  .  .    |..| | |..|   | | . |  | .|.. . | .   ... | | .|  
.ldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
0051082 (Phosphotyrosine protein) phosphatases II 1093-1308 1.3e-26 88.4 In-house 4-149 (151) alignment 
Range on Protein: 1093-1308
Range on HMM: 4-149/151.0
GYINASRVKvPVagellhYIAAQGPMEntvqDWWRMVWESGTQVIAMLTKLKEDGkeKCFKYWPDCTspkkntaefgpfrviaqfsndsgcyitsgltlr
.|||.|.|  .       ... .||..    | .....| | ..| .|....| |  .| .|.|.                                   
dyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

hvpsgeqRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcrhansmneveV-GPPPIVHCSAGVGRTGVLLLVDIMISSlehneeINIPKMMGILRQQR
       ..|.|... |||..|.|.  . .|.|||....              . | .||||||.||||.| ....|.        ... . .  .|..|
.......ievlhipildwpdpglplsfdavleflellld............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

MLMVQTVGQYTFVYKAL
. .||.  |. |...||
pgvvqpnqqflfqlfal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1060-1310 1.7e-25 84.6 In-house 30-268 (285) alignment 
Range on Protein: 1060-1310
Range on HMM: 30-268/285.0
SKLPENVSRNRFKDVLPYEDCRVELSSshHNsGGYINASRVKVPVAgELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCT
.    |   ||. ||   |. || |    |.   || || ...|   .   ||..|||. .|. |.|.|...     . ||  | | | |||  |.|.  
tayeanpdlnryadvrcieetrvvlkn..hd.rdyihaswmrmpgk.dqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

SpkkNTAEFGPFRVIAQFSNDS--GCYITSGLTLRHV--PSGEQRTVWHLQYNDWPNQGCPDDVHGFLsflEEFQSVcRHansMNEVEVgpPPIVHCSAG
    .  .|| . .     ..      |   ||.      | |   . |.|   ||.| .|.| . ..   | .. | ..   .|  |   |  ||||||
g...evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmi...elykwv.kk...vnpkek..picvhcsag

VGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
||||  .. .|     .  | .|..  ..  .|  |.  ||.  |. |.|  |..
vgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme
0044763 (Phosphotyrosine protein) phosphatases II 1077-1309 1.7e-24 81.9 In-house 2-168 (178) alignment 
Range on Protein: 1077-1309
Range on HMM: 2-168/178.0
YEDCRVELSSSHH-NSGGYINASRVKvpvAGellHYIAAQGPmentvQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkntaefgpfrvia
....|| ||.  . ... |||||..     |    |.....|     .|......| | ..| .||. .| |..||..|||. ..               
ldrtrvllsnleglersdyinaseil...pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

qfsndsgcyitsgltlrhvpsgeqrtvWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANsmnevevgPPPIVHCSAGVGRTGVLLLVDIMISSlehn
                           .. ..  .|  |.||    || |.|  ...    .         | .|||||||||.|.| . ..|..     
...........................iqylhipipDhgvpdllehflefvefieealdekg........gpvlVHCsaGvgRsgtlvaaylmkkl....

eEINIPKMMGILRQQRMlMVQTVGQYTFVYKALI
  ..... .  .|..|. .|.. ||. ..|.   
.glsleeaielvrerRp.ivpnpgqlrqLyefel
subfamily_egg_pd Subfamily egg 1064-1309 3.3e-24 80.1 In-house 39-267 (307) alignment 
Range on Protein: 1064-1309
Range on HMM: 39-267/307.0
ENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDgkEKCFKYWPDCTSPK
.|  . | | |   . .||.|   .   .. .| | |||      | ..| || |. |||.|.||||..   | | |||  ||   |.|  ||| . |  
nnlekarskrvhckdssrvklelrrGqylddfihanrvkG..kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

KNTAeFGPFRVIAqFSNDSGCYI---TSGLTLrHVPSGEQRTVWHLQYnDWPNQGcpdDVHGFLSFLeefqsvcRHANSMNEvevgpPPIVHCSAGVGRT
  |   | .|. . .  ||        . | |   .  |.| . | |. |. | .   ||.  |  |       |..  . .     | .|..  || ..
lvtv.pGslrien.lkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnss...dvysplrvl.......rklrnlsk.....pvvvqdilGvska

GVLLLVDIMISSLEHN--EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..|. ..| . ||         . . .  ||..| | |..| .| |||. ..
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_eak_pd Subfamily eak 1062-1313 7.8e-24 78.7 In-house 49-306 (332) alignment 
Range on Protein: 1062-1313
Range on HMM: 49-306/332.0
LPENVSRNrFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTsp
  |.| ||   ...||.   |.|.||  |  |||||| .. .  |.  .|| .  . |. |  .|.|| |  .  | .| .  | . ||  ||.|| |  
rleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt..

kKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDdVHGFLSFLEEFQSVCR------HAN----SMNEVEVGPP---P
 ..  .|| . |  .     . . |  | |.     |   | | ..  | .   |  .. ||.. .  . |        ...     ..     ||   |
.reelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk.yedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

IVHCSAGVGRTGVLLLVDIMISSLEHN--EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|. .. |  |.||....|..|  .. .  .   . ...   ...|.  | .  |..|.|..... |.
iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1064-1158 3.6e-23 76.8 In-house 46-153 (350) alignment 
Range on Protein: 1064-1158
Range on HMM: 46-153/350.0
ENVSRNRFKDVLPYEDCRVELSS--------SH-HNSGGYINASRVKVPVAGEL----LHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEK
|  ..||.|..||||  ||.|           | ...  ||||. .|... .       .|||.|.|. .||.|..... . . .|| .||.. | . ||
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CFKYWPDC
| .||.. 
cyrYWqeg
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1099-1303 8.7e-23 75.5 In-house 80-272 (301) alignment 
Range on Protein: 1099-1303
Range on HMM: 80-272/301.0
RVKVPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSG-
   .|  |.  ..||.|||..|| .|.| |.     . |.||..  |. .||| .| |  .|   .. . | |..  . ..      .|  ||. . |  
anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis...ekldigrfkikiknkelilnkkiskrtlevedstg

--EQRTVWHLQYNDWPNQGCPDdvhgflSFLEEFQSVCRHANSMNevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMV
  . ||| | ||..|...| |       |  | |. .    .| .      | .||||||.||.  ..  ... . .| . .|.. . .  ||..|   |
kfatrtvthyqysewtdrgvPk......shaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv

QTVGQYTF
||. |  .
qtnsqlyw
0048076 (Phosphotyrosine protein) phosphatases II 1166-1309 8.9e-23 76.0 In-house 11-140 (145) alignment 
Range on Protein: 1166-1309
Range on HMM: 11-140/145.0
AEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHansmnevevGPPPIVHCSAGVGRTGVLLLV
  .|.. .  .. .     ||  |.| . .... |......| .||  |.||.   .|.|||  ... ..         | | .|||||||||||.| . 
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.........ggpvlVHCsaGvgRtgtlvaa

DIMISslehnEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..|..     . ..... .  .|.||. .|...||. |.|... 
ylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1110-1306 3.4e-22 73.6 In-house 6-198 (199) alignment 
Range on Protein: 1110-1306
Range on HMM: 6-198/199.0
HYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQRTVWHLQY
.|||.| |. .|. |.|.||||.|.  | |.   . . .     ||| . |    |...| . | ..       |  . | |          | . | |.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes...gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

NDWPNQGCPDdVHGFLSFLeefqSVCRHANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE--INIPKMMGILRQQRMLMVQTVGQYTFVY
  | ..  |. |  |. |.       |      | |   | ||||| | | |||.. .|| . | |      ... ..   ||| |  .. .. .| |.|
tswkekttpn.valfvgfv....vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

K
.
q
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1110-1306 3.4e-22 73.6 In-house 5-197 (198) alignment 
Range on Protein: 1110-1306
Range on HMM: 5-197/198.0
HYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQRTVWHLQY
.|||.| |. .|. |.|.||||.|.  | |.   . . .     ||| . |    |...| . | ..       |  . | |          | . | |.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes...gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

NDWPNQGCPDdVHGFLSFLeefqSVCRHANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE--INIPKMMGILRQQRMLMVQTVGQYTFVY
  | ..  |. |  |. |.       |      | |   | ||||| | | |||.. .|| . | |      ... ..   ||| |  .. .. .| |.|
tswkekttpn.valfvgfv....vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

K
.
q
FERM_M FERM central domain 108-222 2.8e-20 62.9 Pfam-A 4-126 (126) alignment 
Range on Protein: 108-222
Range on HMM: 4-126/126.0
TLRHEMTRYMYFLQLKSDFIEGILPCNEEQAVTLASFALQAEIGNSD-PAKHTVEF-YQNE-YV----LLP-KNMTTENVSLSELLLKVMNAHQAKVGMS
 ...|........|.|.|..|. |.|.||.|. ||. .||.|.|.|. . |..     ..| .     ||| .    .. . ..|  ....||.   |.|
pkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknvagls

TCQSELGYIEQAAKLQGYGQESF
  . .| |.. | .|..|| . |
laeaklkylqaaqslpdyGvslF
FERM_N FERM N-terminal domain 25-102 1.5e-18 56.8 Pfam-A 1-79 (80) alignment 
Range on Protein: 25-102
Range on HMM: 1-79/80.0
IQLLDSAVLEITLTPESLGQDCLDTIAQKLQLEENIYFGLQY-SNKNYKLRWVDLEKPLKKQLDKNAHDSMLRLGVMLY
..|||..|.|.|. ... |...|.|....|.|.|. ||||..   |. . .|.|..| |..|....  . .| | |  |
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfy
0048179 (Phosphotyrosine protein) phosphatases II 1188-1306 5.6e-18 60.5 In-house 35-139 (144) alignment 
Range on Protein: 1188-1306
Range on HMM: 35-139/144.0
GLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVcrhansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMIsslehNEEINIPKMMGIL
 ||  . |  . |....... .||. |.||. . .|.||| ....         .| | | .|||||||||||.| . ..|.      . ... . .  .
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieea.........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalv

RQQRMLMVQTVGQYTFVYK
|..|. .|.. ||. |...
rsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1029-1313 2.2e-17 57.5 In-house 16-286 (302) alignment 
Range on Protein: 1029-1313
Range on HMM: 16-286/302.0
RKILEKQLREGQVFTEYEQITKK-REGAVCYTSKlpENVSRNRFKDVLPYEDCRVELSsshHNSGGYINASRVKVPVAGelLHYIAAQGPMENTV---QD
 | | |.| ...| .|...| .   .   | . |  .|...|. .||  ... .| |.   ..   |.|||.|.||  .     | || |  ...   ..
akklvksldtaevkkefkkidtmkvdlekCkafk..knlkknqsedvpildsnlvkle...aepdsyvnaskvevPelt..rsiilaQlpkvdsedsvee

WWRMVWESGTQVIAMLTKLKEDGKeKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSgCYITSGLTLRHVPSGEQRTVWHL--QYNDWPNQGCPDDVHgf
.||||..   . . .| . .|  |    ...|  .    .  |.| ..|  .  . .    .. ...  .| |   .|       . |...  |. .   
FWrmvfqekivsvvilvgeeelkk.tlselfpkks...gdykeygkmfvNnrkVeka.eeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya..

lSFLEEFQSVcrhanSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
 .  .. ..|      ......  . ..    |.|| |..| . . ...|....| ||  ..  .|.||  .|... ||...| ||.  .|
.eliktaakv.....fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1201-1309 2.2e-16 54.5 In-house 216-341 (350) alignment 
Range on Protein: 1201-1309
Range on HMM: 216-341/350.0
TVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRH--ANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISS-------LEHNEEIN--------IPKM
 |..||.. |.. .   . . .|. ||  . .     |.|  . . ..| .|||||||||||.|. .| ..|         .. ....        |  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

MGILRQQRMLMVQTVGQYTFVYKALI
. .||.||. |||.. |. |.|.|| 
vnelrkqrismvqnldqfifiYeall
subfamily_CG42327_pd Subfamily CG42327 1247-1309 7.1e-16 52.7 In-house 249-312 (319) alignment 
Range on Protein: 1247-1309
Range on HMM: 249-312/319.0
PPIVHCSAGVGRTGVLLLVDIMISSLEHN-EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
| .|||| ||||||...  || | |||.. . ..||...  .|..|   |.|. || |.|| | 
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1045-1310 1e-15 52.2 In-house 28-277 (303) alignment 
Range on Protein: 1045-1310
Range on HMM: 28-277/303.0
YEQITKKREGAVCyTSKLPENVSRNRFKDVLPYEDCRVELSSSHhnsggYINASRVKVPVAGellHYIAAQGPMENTVQDWWRMVWESGTQVIAML-TK-
.|...      |.   .. .|. .||| ||.  .  .|.|| |      || || ...       . | .| |.  |  |.|.|. |   ... .| |  
fekvvsylppsvs.knqfvknmdknrfvdvicldhskvklsdss.....yihasyleldssk...kailtqlplshtaadfwqmiieqkvkcvlllltds

-LKEDGKEKCFKYWPDCTSPKKNTAEFGPFRviaqfsndsGCYITSGLTLR--HVPSGEQRTVWHL-QYNDWPNQGCPDD-VHGFLSFLEEFQSVCRHAN
  .. | .  |    |    .. .   | |.            .. | .|.   |  |. ..  |. .|..|| .  | |    |.  . . ||| |.  
eydklggdsvfprnqdflkfeersirvgefk.........rvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys

SmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEH-NEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
       . |..    .|.||.| . | .    ||   .  ... | .  .|. |.  || . |...||  | .
d......stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1197-1312 2.2e-15 51.0 In-house 86-194 (440) alignment 
Range on Protein: 1197-1312
Range on HMM: 86-194/440.0
GEQRTVWHLQYNDWPNQGCPDDVHGFLSFLeefQSVcrhaNSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQ
 | ||. . .|. ||..| |  .   | ..   | |    |  .|     | .||||||.|||||.. || ..   .....|.|  ..  .|..|  |||
iesrtlkqyhyqgwpdkgvpkfagpvlkmi...qdv....nesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvq

TVGQYTFVYKALIQSL
|  ||.||..|....|
tpeqyafvheavlegl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1121-1305 3.4e-14 47.5 In-house 40-214 (255) alignment 
Range on Protein: 1121-1305
Range on HMM: 40-214/255.0
TVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKNTAEfgpFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVH
||. .....  ..|.|..||. ..|.|.||| .|.|     |.  |.     |..  |       |  .|.      . .|| | .|. |...  |.. .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad...vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

GFLSFLEefqsVCRHANSMnevevgpppIVHCSAGVGRTGVLLLVDI----MISSLEHNE--EINIPKMMGILRQQRMLMVQTVGQYTFVY
  |  |     | |.. |.         .||||.|.||.  . |...    || ||.  |  |..  ...  ||..|   ..|  | .|  
eilnilk....vvrdsksv.........vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1065-1158 1.5e-13 44.8 In-house 48-156 (349) alignment 
Range on Protein: 1065-1158
Range on HMM: 48-156/349.0
NVSRNRFKDVLPYEDCRVELSSSHHNS---------------GGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKE
  ..||.||.||||  || |  | ..|                 ||||  .|..      .||| | |.  ||.|.....   | ...  |.. || . |
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCFKYWPDC
|| .|| . 
kcdiywqel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1116-1308 2e-13 44.5 In-house 98-284 (302) alignment 
Range on Protein: 1116-1308
Range on HMM: 98-284/302.0
GPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTspkKNTAEFGPFRV--------IAQFSNDSGCYI-TSGLTLRHVPSGEQRTVWHLQ
 |  .|.. .| .. .  . ... |....||...|| .|. |     ... .|| . |        ...|..  .  . |  ..  .. .  ..||  |.
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv...ggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

YNDWPNQGCPDDVHGFLSFLeefqsvcRHANSMNEvEVgpppIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYK
.  ||. | |.. .  |  |       .. .|  . .|    .||||||||||| |. .   |    ...  .. ...  .|| |   ||.  | ...  
fsawpdhGapkeaytaldil.......kfcesykk.nv....lvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll

AL
 .
cv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1201-1310 1.4e-12 41.6 In-house 219-342 (349) alignment 
Range on Protein: 1201-1310
Range on HMM: 219-342/349.0
TVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMNEVE--VGPPPIVHCSAGVGRTGVLLLVDIMIS--SL--EHNEEINIPKM--------MGI
 .. ||. .|.. .   .   .|  ||  . .    .. . ..    .. .|||||| ||||||  .|...|  .   ..   |... .        . .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRQQRMLMVQTVGQYTFVYKALIQ
||.||. ||| . |. ..|.||..
lrkqrismvqnlaqfiaiyealLk
FERM_C FERM C-terminal PH-like domain 226-306 1.1e-11 35.1 Pfam-A 1-84 (90) alignment 
Range on Protein: 226-306
Range on HMM: 1-84/90.0
DDSGNELFISASFSGLSVKHLNRQE-TVHFEWHEVVSMGHNRRAFGVGTS--RSHDVLQFQMEDAETAKYVCRICRLQQQFHKY
. .|..|... . .|| . . |..    .|.|.|.  . .... | . ..   . |||.|........|.....|  ...... 
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1091-1308 1.5e-11 39.0 In-house 45-255 (290) alignment 
Range on Protein: 1091-1308
Range on HMM: 45-255/290.0
SGGYINASRVKVPVAgelLHYIAAQGPME-------NTVQDWWRMVWESGTQVIAMLTKLKEDGKE----KCFKYWPDCTSpkkNTAEFGPFRVIAQFSN
. .|| |.||..|     |. |. | | |        |....| |. .   . . || . .|  ..     | || |.      .   |. . |  .   
nddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg...eelkfkgltvkCkske

DSGCYITSGLTLRHvPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvCRHAnsmnevevgpPPIVHCSAGVGRTGVLLLVDIMISSLE-HNEEI
     .|  |....   .|. || | ....| .   ..|   .|| ..  .  ....          | ||||  |. |  .|  ...    .   ....
keddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvk..askt..........pvivHcvdGiSrsAalaaiilgyQkiaetsgsv

NIPKMMGILRQQRMLMVQTVGQYTFVYKAL
.. ...  ||.|| |....  ...||  ..
kledvlkalrkqralaitsalelafvdagi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1050-1158 1.6e-10 35.1 In-house 81-181 (244) alignment 
Range on Protein: 1050-1158
Range on HMM: 81-181/244.0
KKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHnSGGYINASRVKvpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGke
 . . .|   .  |.|  .||    ||..  || || .   .  ||||| |     |    || .| |. .|  |.|.|. |   .|. .|  ..|.   
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsm.gntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed..

kcfKYWPDC
   .|||| 
...eywpds
subfamily_hpo-7_pd Subfamily hpo-7 1120-1305 2.1e-10 35.0 In-house 45-220 (263) alignment 
Range on Protein: 1120-1305
Range on HMM: 45-220/263.0
NTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKNtaeFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDV
.|..  ....  ..|.|..||.  .|.|.||| .|.|     |.    .    | .  . .     |  |.       . .|| | .|. |...  | . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk...lanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

HGFLSFLeefqsvcRHANSMNEVEvgpppiVHCSAGVGRTGVLLLVD----IMISSLEHNEE--INIPKMMGILRQQRMLMVQTVGQYTFVY
.  |  |       . |    ...      ||||.|.||.    ...     || ||.  .   ..  ...  ||..|   ..|  |  |  
reilnil.......kvarnskslv......vhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1056-1150 3.8e-09 30.5 In-house 28-127 (347) alignment 
Range on Protein: 1056-1150
Range on HMM: 28-127/347.0
VCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH------HNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWE-SGTQVIAMLTKLKEDGK
 . ...   ..|.|| |||   .. || ||  .       .. .||||| .|   | .  .|| .| |. .||.|.|.||     |||....   |..  
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnask..eyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai

EK
|.
ee
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1249-1313 5.8e-08 27.0 In-house 2-66 (69) alignment 
Range on Protein: 1249-1313
Range on HMM: 2-66/69.0
IVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
.||||.| |||| .. . . .. .  .  ..|   .  .|. | .||    .| |.. ||...||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1249-1314 7.6e-08 26.6 In-house 1-66 (69) alignment 
Range on Protein: 1249-1314
Range on HMM: 1-66/69.0
IVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
.||||.| |||| .. . . .. .  .  ..|   .  .|. | .||    .| |.. ||...|| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1111-1177 3.9e-07 23.7 In-house 238-297 (440) alignment 
Range on Protein: 1111-1177
Range on HMM: 238-297/440.0
YIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEdgkEKCFKYWPDCTspkkNTAEFGPFRVIAQF
.||.| |.. || |.||.| .     | || .|..     |  |||  |     .  |||| |  . 
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt....rsvtfgpftvghkg