Gene PTPN14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP058_AA protein Get Run
SpurP058_AA_1023-1313 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN14_pd Subfamily PTPN14 1019-1316 6.9e-154 506.2 In-house 3-300 (300) alignment
Range on Protein: 1019-1316
Range on HMM: 3-300/300.0
EETKHPRDARRKILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGELLHYIAAQGPM
| |....|.|.|||||.|.||.||||||.|.|||| |...|.|||||...|||||||||||.|||||....|| ||||||..||.|.|. ..||.||||.
eatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl

ENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDD
|.||||.|.||||.|.|.|.|||. .||||||.|||.|...| ||.|.||| |.|...||.||...||.||.|.|.||.|.||||||||.|||..|.|.|
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeD

VHGFLSFLEEFQSVCRHANSMNE-VEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNTR
|.||||.|||.|||.|..||..|  |. || .|||||||||||||.|.|..|..|||||||.|.|....||.||||.|||..||.||||.||..|||.|
vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr

0050432 (Phosphotyrosine protein) phosphatases II 1022-1314 2.4e-85 281.9 In-house 25-301 (308) alignment
Range on Protein: 1022-1314
Range on HMM: 25-301/308.0
KHPRDARRKILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELssshHNSGGYINASRVKVPVAGELLHYIAAQGPMENT
|.. .   |.|||.|  |....|.|..... .   .....||||...||.||.|||. .|| |    ... .||||| |.... .   ..||.|||..||
klsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpnt

VQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHG
| |.|||||| ...|| ||||| |.|.|||..|||. .  .... |.|.|.|        . |..  |.|... .|| |||.|..| .||..|.|...  
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplel..gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

FLSFLEEFQSVCRHansmnevevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
.|.|||. ......          .| .|||||||||||.....|.... ||.. ........  ||.||. ||||. || |.|.||.  ||.
lldflelvrkslpg..........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0051299 (Phosphotyrosine protein) phosphatases II 1039-1312 1.8e-81 269.1 In-house 23-286 (288) alignment
Range on Protein: 1039-1312
Range on HMM: 23-286/288.0
GQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVWESGTQVI
 ... |.|..... .   .....||||...||..|.|||...|| ||. .  ....||||| ....  .    .||.|||..||| |.|||||| ...||
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvI

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHV----PSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVC
 ||||| |.|.|||..|||.     ... ..|...|        . |..  |.....    ..|| |||.|..| .||..|.||..  .|.||.......
vmltklvelgrekcaqYwpl.....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

RhansmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
.          |.| .|||||||||||.....|.... ||...........  ||.||. ||||. || |||.||.  |
a........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 1030-1316 2.1e-80 265.5 In-house 4-281 (297) alignment
Range on Protein: 1030-1316
Range on HMM: 4-281/297.0
KILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELsssHHNSGGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMV
|.|||.|   .. .|.|....      .....||||...||.||.|||...|| |   .... .||||| |  .. .   ..||.|||..||| |.||||
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmv

WESGTQVIAMLTKLKEDGKEKCFKYWPDCtspKKNTAEFGPFRVIAQFSND--SGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLE
|| ...|| |||.| |.|.|||..|||.    . .. ..|.|.|  .  .   .. |..  |.. .. .||.|||.|..| .||  |.|...  .|.|.|
weqnvtvIvmltelvelgrekcaqywple...egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

EFQSVCRHANSMnevevgPPPIVHCSAGVGRTGVLLLVDIMISSLE---HNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNTR
....|.....|       .| .|||||||||.|.....|.|.. ||   ......|....  ||.||. .|||..|| |.| ||.. ||...
lvrkvlkllpsg......gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

subfamily_PTPN3_pd Subfamily PTPN3 1031-1313 4.5e-80 263.6 In-house 7-276 (280) alignment
Range on Protein: 1031-1313
Range on HMM: 7-276/280.0
ILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHnsgGYINASRVKVPVAG--ELLHYIAAQGPMENTVQDWWRM
 |...|. |.|....||. .|..|  . ....|||.|.||..|.|||.. ||.|..|.     ||||. |.. . .     .|||.|||...|..|.|.|
llkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqm

VWESGTQVIAMLTKLKEDGKEKCFKYWPDctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEE
|||  ...| ||| | |.|. || .|||.    .... |.| |.|  . .. .  |..  |.|..  . |.|.. .||| .||..| ||| . ||.|.|.
vweqksslivmlttlverGrvkChqyWPe....tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefver

FQSVCrhansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
 ...              | .||||||.||||||.|... .. .|..|........  .|.||. .|||..||.|| .|...  .
vrklr........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

0046845 (Phosphotyrosine protein) phosphatases II 1042-1314 7.6e-79 260.3 In-house 3-276 (284) alignment
Range on Protein: 1042-1314
Range on HMM: 3-276/284.0
FTEYEQITKKREGA--VCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH--NSGGYINASRVKVPVA---GELLHYIAAQGPMENTVQDWWRMVWESGT
. |.|....        .....||||.|.||.||.|||...|| |.| ..  ....||||| |...         ..||.|||..||| |.|||||| ..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

QVIAMLTKLKEDGKEKCFKYWPDCtspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVC
.|| |||.| |.|.|||..|||.     ... ..|.|.|     .  ..|..  |.|...  .|| |||.|..| .||..|.|...  .|.||.. ....
rvIVmltelvengrekcaqYwple....gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

RHansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNE---EINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
..      .. |.| .|||||||||||.....|.... ||...   ........  ||.||. ||||. || |||.||.  ||.
en......lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0047943 (Phosphotyrosine protein) phosphatases II 1031-1310 9.3e-79 260.0 In-house 4-270 (273) alignment
Range on Protein: 1031-1310
Range on HMM: 4-270/273.0
ILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELsssHHNSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVW
.|||.|  .... |.|....  .   .....|||| ..||.||.|||...|| |   .... .||||| |...  .    .||.|||..||| |.|||||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvw

ESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQ
| ...|| |||.| |.|.|||..|||.      .. ..|.|.|     .  ..|..  |.|... .|| |||.|..| .||..|.|...  .|.|.|. .
eqnvrviVmLtelvelgrekcaqYwplegge..lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

SVCRHANSMnevevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.......|       .| .|||||||||||.....|.... ||.. ...... .  ||.||. ||||. || |.|.||. 
kalealpsn......gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 1039-1314 9.5e-76 250.4 In-house 18-278 (317) alignment
Range on Protein: 1039-1314
Range on HMM: 18-278/317.0
GQVFTEYEQITKKREGaVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVI
...  |.|.. .      . ...|||| ..||..|.|||...|| ||.    .. .||||| |..|   .  ..||.|||..||| |.|||||| |..||
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgp..nlkrkfIatqgPlpntvedFwrmvweqgvtvi

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhan
 |||.|.|.|.|||..|||.     ..| ..|.|.|  .     . ..   |.. .  ..|.|||.|..| .|| .|.|..   .|.|||. .....   
vmLteleelgrekcaqYwpl.....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...

smnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
     . | | .|||||||||||.......|.. ||......... .  ||.||. .||| .|| |.|.||.. ||.
.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

DSPc_SM00195 1041-1311 1.6e-75 249.2 In-house 2-261 (263) alignment
Range on Protein: 1041-1311
Range on HMM: 2-261/263.0
VFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
. .|.|.. ....   . ... ..|.|.||.|..|||.. ||.|..... ..  ||||. .|..   .  .|||.|||...||.|.|||||| ....|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTKLKEDGKEKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSG-CYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHAns
||. .|.||||| .|||.     ... .|| ..|  .  .     .|.  |.|..    |.|.| ..||..||..|.||. . .|..|.....  ..   
lteeeengkekcdrywpees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

mnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
       .| .|||||||||||.....||..|.||......| ...  ||.||. ||||  ||.|.|.|... 
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 1041-1311 1.6e-75 249.2 In-house 2-261 (263) alignment
Range on Protein: 1041-1311
Range on HMM: 2-261/263.0
VFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
. .|.|.. ....   . ... ..|.|.||.|..|||.. ||.|..... ..  ||||. .|..   .  .|||.|||...||.|.|||||| ....|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTKLKEDGKEKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSG-CYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHAns
||. .|.||||| .|||.     ... .|| ..|  .  .     .|.  |.|..    |.|.| ..||..||..|.||. . .|..|.....  ..   
lteeeengkekcdrywpees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

mnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
       .| .|||||||||||.....||..|.||......| ...  ||.||. ||||  ||.|.|.|... 
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_PTPRD_pd Subfamily PTPRD 1039-1313 2.1e-74 246.2 In-house 23-282 (564) alignment
Range on Protein: 1039-1313
Range on HMM: 23-282/564.0
GQVFTEYEQITKKrEGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQVI
 ....||..|... .   . ... |.| ..||......|. .|| ||. . ..   ||||| ..     .  .|||.|||...|..|.||||||  ...|
lkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnssti

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhan
 |||||.| ||.|| ||||.     |.|...| . |  . ...   |.   ..|..  | |.|.| . .. .||..| |.   ..|..... ... .   
VmltkleEkgkvkchkYWPe.....kgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...

smnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
     .   | .|||||||||||. . .|.|.  ..... ..| ...  ||.||  ||||  || |...|. . |.
.....pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

0039614 (Phosphotyrosine protein) phosphatases II 1030-1314 3.6e-73 241.9 In-house 23-291 (297) alignment
Range on Protein: 1030-1314
Range on HMM: 23-291/297.0
KILEKQLREGQVFTEYEQITKKREGavCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH--NSGGYINASRVKVPVA-GEllHYIAAQGPMENTVQDWW
. |||..  .....|.|.. .  .   .....||||...||.||.|||...|| |..  .  ..  ||||| |...   .   ..||.|||...|| |.|
lllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatqgPlpetvedFw

RMVWESGTQVIAMLTKLKEDGKeKCFKYWPDCTSpkkntaEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFL
||||| |..|| |||||.|.|. ||..|||. ..      ..|.|.|        . |..  |....  .|| |||.|.|| .||  |.|...  .|.||
rmvweqgvtvivmLtklvelgr.kcaqywpeegg......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

EEFQSVCRHAnsmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
|. .......      . | | .|||||||||||.... ..|.. ||.. ...... .  ||.||. .||| .|| |.|.||.. ||.
elvrealael......pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0045450 (Phosphotyrosine protein) phosphatases II 1041-1311 3.8e-72 238.9 In-house 29-303 (307) alignment
Range on Protein: 1041-1311
Range on HMM: 29-303/307.0
VFTEYEQITKKRE--GAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH--NSGGYINASRVKV------PVAGELLHYIAAQGPMENTVQDWWRMVW
.. |.|.. .        .....|||| ..||.||.|||...|| ||| ..  ....||||| |.|      ..    ...||.|||...|| |.|||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

ESGTQVIAMLTKLKEDGKEKCFKYWPDCtspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHV-PSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEF
| |..|| |||.|.|.|.|||..||||     . . ..|.|.|     .  . |.   |.. .  ..|| |||.|..| .||..|.|...  .|.|.|| 
eqgvtvivmltelvelgrekcaqywPde....geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

QSVCRHansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE---INIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
......         | | .|||||||||||.... ..|.. ||....   ..... .  ||.||. .||. .|| |.|.||.. 
rkalee......lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0043336 (Phosphotyrosine protein) phosphatases II 1040-1309 7.6e-72 237.4 In-house 21-274 (278) alignment
Range on Protein: 1040-1309
Range on HMM: 21-274/278.0
QVFTEYEQITKKREgAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIA
 .  |.|....      .....||||...||.||.|||. .|| ||. . ... .||||| |  ..     ..||.|||...|| |.|||||| |...| 
llllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvttiv

MLTKLKEDGKEKCFKYWPdctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhans
|||.|.|.|..||..|||      ... ..|.|.|  .  .  . |..  |.. .  .|| |||.|..| .|| .|.|...  .|.||........    
mLtelvelgrvkcaqYwp......ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale....

mnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
      . | .|||||||||||.......... ||.. ...... .  ||.||. .|||  || |.|.||.
....dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

subfamily_PTPN6_pd Subfamily PTPN6 1033-1315 2.3e-70 232.0 In-house 20-300 (306) alignment
Range on Protein: 1033-1315
Range on HMM: 20-300/306.0
EKQLREGQVFTEYEQITKKREG--AVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVW
|..|    .  |.|.. .. .        .. ||| ..||.| .||... || |....     ||||. .|  | |.  .|||.|| .|.||.|.|||||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

ESGTQVIAMLTKLKEDGKEKCFKYWPDctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEf
.  ..|| |.||  | ||||| .||||    .... |.|  .|    ...   ||   |.. .   ..|.|.|.......||..|.| |   .|.|||. 
qensrvivmttkevErgkekCarYWPd....eeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled.

qsVCRHANSMNEVEVGPpPIVHCSAGVGRTGVLLLVDIMISSLEHN---EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNT
  | |......| | ||  .||||||.|||| ....||... .|..    .|.| |.. ..|.||  .|||  || |||||. . ....
..vnrkqeeleeaeagp.ivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk

0045098 (Phosphotyrosine protein) phosphatases II 1038-1313 2.4e-70 232.4 In-house 6-273 (278) alignment
Range on Protein: 1038-1313
Range on HMM: 6-273/278.0
EGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVElssshhnsgGYINASRVKVPvaGelLHYIAAQGPMENTVQDWWRMVWESGTQVI
......|.|..        .... ...|...||.||.|||. .||          .||||| ....  .   ..||.|||...||.|.|||.|| |..||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..p..kkfIatqgPlpstvadfwrmlwelgitvi

AMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHV----PSGEQRTVWHLQYNDWPNQGCPDDV--HGFLSFLEEFQS
 |||.|.|.|.|||..|||.     ... ..|.|.|  .     ..|..  |.....    ...|.|.|.||.|  ||  |.|..     ||..||. ..
vmltelvelgrekcaqywpe.....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefire

VCRHANSMNEVE-----VGPPPIVHCSAGVGRTGVLLLVDIMISSLehNEEINIPKMMGILRQQRML-MVQTVGQYTFVYKALIQSLK
......|. ...      | | .|||||||||||.| ....|.. |  .. .....    ||.||.  .||. .|| |.|..|.. |.
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN13_pd Subfamily PTPN13 1031-1314 3.9e-70 231.2 In-house 3-271 (273) alignment
Range on Protein: 1031-1314
Range on HMM: 3-271/273.0
ILEKQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSsshhNSGGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVW
 |.|.| ..|   |.... . .    | ..|  || ..||...||||.. ||.|.    ..||||||| .||||  .  .|||.|||. .||.| |.|||
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvw

ESGTQVIAMLTKLKEDGKEKCFKYWPDCTspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQ
|  ..||||.|. ||.|| || .|||. .  .|..   . ..|     ..   .  . |..... ||| | | ||.. .||. | |     .| |. | .
eqkaeviamvtlekekgkvkchrywPesk..nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr

SVCRHANsmnevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
.. ..|          | .||||||.||.|.|. .|...  .|...|... ...  ||.||  .|||  || |||||... ||.
rlqtdag.........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

Y_phosphatase Protein-tyrosine phosphatase 1065-1309 1e-68 226.6 Pfam-A 1-234 (235) alignment
Range on Protein: 1065-1309
Range on HMM: 1-234/235.0
NVSRNRFKDVLPYEDCRVELSSSHHNSGgYINASRVKVPVAgeLLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPdctSPKKN
| ..||.||.|||.. ||.|..| ..|  ||||. ||        ..||.|||...|..|.|||||.  ..||.|||.|.| |.||| .|||   . ...
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp...eeeee

TAEFGPFRVIAQ--FSNDSGCYITSGLTLRHVPSG-EQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCrhansmneVEVGPPPIVHCSAGVGRTGV
. ..| ..|  .   ..|.  |... |.|..  .  |.|.|..|.|..||..|.|......|........           .   | .|||||||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgt

LLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
....||....||..||... ...  ||.||. |||.. || |.|||..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1065-1309 1e-68 226.6 In-house 1-234 (235) alignment
Range on Protein: 1065-1309
Range on HMM: 1-234/235.0
NVSRNRFKDVLPYEDCRVELSSSHHNSGgYINASRVKVPVAgeLLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPdctSPKKN
| ..||.||.|||.. ||.|..| ..|  ||||. ||        ..||.|||...|..|.|||||.  ..||.|||.|.| |.||| .|||   . ...
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp...eeeee

TAEFGPFRVIAQ--FSNDSGCYITSGLTLRHVPSG-EQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCrhansmneVEVGPPPIVHCSAGVGRTGV
. ..| ..|  .   ..|.  |... |.|..  .  |.|.|..|.|..||..|.|......|........           .   | .|||||||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgt

LLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
....||....||..||... ...  ||.||. |||.. || |.|||..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0040439 (Phosphotyrosine protein) phosphatases II 1057-1313 3.3e-68 225.3 In-house 3-247 (249) alignment
Range on Protein: 1057-1313
Range on HMM: 3-247/249.0
CYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYW
.....||||...||..|.|||. .|| ||. . .. ..||||| ....  .   ..||.|||...|| |.|||.|| | .|| |||.|.| |.|||..||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikr..rfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHAnsmnevEVGPPPIVHCSAG
|.     ... |.| |.|     . .. |..  |.| ..  || |||.|.|| ||| .|.|...  .|.|.|. .......      . | | .||||||
pl.....ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel......pkggpvlVHCsaG

VGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|||||.... ..|.. ||.. .....  .  ||.||. .||. .|| |.|.||.. |.
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1039-1313 1.5e-66 219.7 In-house 18-281 (318) alignment
Range on Protein: 1039-1313
Range on HMM: 18-281/318.0
G--QVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSG-GYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQ
|  ....|||......| .  . |  | |  .||. ..|.|...||.|.  . . |  ||||. .      .   |||||.|. .|..|.|||||| ...
GelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidG..yrrkkayiaaqaPlpetieDfWrmvWeqnsa

VIAMLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVcrh
|| |||...| ||.|. .|||.     |.. ..|  .| .. . ... |.   .....  . |.|.|   .| .||..| |... ..|... . ...   
vivmltqeeergkakvhryWPs.....kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska...

ansmNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
    .. .   | .|||||||||||| . |||..  ..... ... ...  ||.|| |||||  ||.|.|..|.. |.
....qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

0037934 (Phosphotyrosine protein) phosphatases II 1057-1310 7.5e-66 217.4 In-house 2-240 (243) alignment
Range on Protein: 1057-1310
Range on HMM: 2-240/243.0
CYTSKLPENVSRNRFKDVLPYEDCRVELssshhNSGGYINASRVKVPvaGellHYIAAQGPMENTVQD----WWRMVWESGTQVIAMLTKLKEDGKEKCF
.....||||.|.||..|.|||.. || |     ....||||. ..|.  .   ..|| |||...||.|    .|||.|| |..|| |||.|.| |.|||.
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt..p...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPdctspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMNEVEVGPPPIVH
.|||       .. ..|.|.|    ..  . |.   |.|.... ....|.|.|..|  || .|.||..  .|.||.| ..... ..|..    | | .||
qywp.......gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSAGVGRTGVLLLVDIMISSLehneEINIPKMMGILRQQRML-MVQTVGQYTFVYKALIQ
|||||||||.|.. ..|.. |    .... . .  ||.||.  .||| .|| |.|.||..
CsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPRB_pd Subfamily PTPRB 1040-1314 1e-65 216.7 In-house 26-287 (293) alignment
Range on Protein: 1040-1314
Range on HMM: 26-287/293.0
QVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIA
..  |||.. .  .   . ...|..| ..||....|||.  ||.|.. ... .  ||||. .  |      ..||.|||. .||.| ||||||. ...| 
rfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi..pgynsprefiatqGPlpetvddfWrmvwekkssiiv

MLTKLKEDGKEKCFKYWPDCtspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANS
|||.| | ||.|| .|||.     ...  .|  .|  . ...   ...  |....  . |.|.| ....  ||. | |.. . .|.|....... ....|
mltqlvekgkvkCeeYWPad....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektas

MNevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
..      | .|||||||||||... .| .....|... ..|  ..  ||..|.|.|||. || |....... |..
kr......PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0042113 (Phosphotyrosine protein) phosphatases II 1058-1312 1.2e-65 216.6 In-house 2-243 (245) alignment
Range on Protein: 1058-1312
Range on HMM: 2-243/245.0
YTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVkvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWP
 ...||||...||..|.|||...|| ||.  ..   .||||| |  ..     ..||.|||...||.|.|||.|| | ..| |||.. |.|..||..|||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

DctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHansmnevEVGPPPIVHCSAGV
.     ... ..| |.|     .  . |..  |.. .....|.|.|.|..| .|| .|.||..  .|.|||. .....          . | .|||||||
l.....gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......dsngpvlVHCsaGv

GRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
||||.......|.. ||.. ...... .  ||.||. .||| .|| |.|.||.. |
gRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPN9_pd Subfamily PTPN9 1037-1310 6.8e-65 214.0 In-house 14-288 (297) alignment
Range on Protein: 1037-1310
Range on HMM: 14-288/297.0
REGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSS-HHNSGGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQ
..  .  ||..| ..      ..|||. |...||..||| |.. || |..  ...   ||||. |      .   .||.|||...||.|.||||||. . 
gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvWeqevl

VIAMLTKLKEDGKEKCFKYWPDCtspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSV---
|| | |.. | |. || .|||.    ....|||| ..|     . .  | .. |....|  .|.|.| | |.  ||. | |.. . .| .||. ..    
vivmttrvvergrlkcgqyWple...eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

--CRHANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
     ... .    ||| .||||||.|||| .  .|| .| ||. . ... . .  ||.||  ..||  ||.| |.|...
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1041-1314 8.6e-64 210.3 In-house 17-278 (281) alignment
Range on Protein: 1041-1314
Range on HMM: 17-278/281.0
VFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
  .|||....   . .   || .||| .||....  |.  ||...  .....  ||||. |.  . ||  .|||.|||. ......|.||||   ..|.|
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykge.keyiatqgPvPaslvafWqmvweqkvsaivm

LTKLKEDGKEKCFKYWPDCTSpkknTAEFGPFRVIAQFSNDSGCYITSGLTLrHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSm
.|.  | || || .|||| .|    . ..| ..|  . ....  ||.  ..| .  |||.|.| .|.|  ||..| |.. . .|.| .| ... .. .  
vtreieagklkChrYWPddns....elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.

nevevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHN-EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
       | ..||||||||||. . .| .....|.. ||...  ..  ||..|.|||||| ||.|||||... |..
......aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1061-1311 8.5e-63 206.8 In-house 13-263 (270) alignment
Range on Protein: 1061-1311
Range on HMM: 13-263/270.0
KLPE---NVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKvPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWP
.|||   .   ||..|.||    || |.. ...|   ||||  |.  . ||  .||||.||...|....|||.||. .. |.|.|.|.|.|..|| .|||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr.GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

DcTSPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRhvPSGEQRTVWHLQYNDWPNQGCPDDVHGFL---SFLEEFQSVCRHANSMNEVEvgpPPIVHCS
   . .| . |.|  .|.|. .. .  ||.  |.|.   .||.| . | .||.||..| | .  . |   . |. .. | |. ..... |   | .||||
a.epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae...PllvHcs

AGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
|||||||.|...||..  ||....... ...  ||..|| .||.. ||.|.|||... 
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_PTPN12_pd Subfamily PTPN12 1056-1313 1.9e-62 205.8 In-house 31-278 (290) alignment
Range on Protein: 1056-1313
Range on HMM: 31-278/290.0
VCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKY
   ... .||| .||.||.|||.  |||||  ...   .||||. .| .   . |.|||||||. .|..|.|||.||  .... |. .. | || || .|
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv..egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPDCTspkKNTAEFGPFRVIAQFSNDSG-CYITSGLTLRHVpsGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRhansmnevEVGPPPIVHCS
||. .   ... |||.|.|  .  .     ..   |....   .|.|.|  ..|..||..|.|  ..  |...|..... .        .   | .||||
Wpeeg...eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe........sedaPlvvhCs

AGVGRTGVLLLVDIMISSLEHN---EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|||||||... .|.. . |...   ||... ...  ||.||  .|||  ||..||||... ..
aGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1039-1310 2.2e-62 205.7 In-house 21-277 (288) alignment
Range on Protein: 1039-1310
Range on HMM: 21-277/288.0
GQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVI
 ..  ||.....  .     ...|..| ..||....|||.  ||.|    . ..  ||||| ...   ..  .|||.|||. .||.|.|..|.|  |. |
tgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg..ekkkkkyiatqgPladtvndfWelvyenktsti

AMLTKLKEDGKEKCFKYWPDCTSPKkntaEFGPFRVIAQFSNDSGCYITSGLTLRhvPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvcrHAN
.|||.| |.||.|| .||||   ||    ..| . |... |.. . ...  | |    ....... ..||  ||..| |.. . .| .|.  .     ||
vmltelveggktkCeeYWPdadkpk....nyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvk....van

SMNevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
. .      | ||||||||||||. . .| .|  .|... |..  ..  ||.||.|.|||. || |.|..|..
qad....tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1031-1313 2.4e-60 199.3 In-house 13-284 (305) alignment
Range on Protein: 1031-1313
Range on HMM: 13-284/305.0
ILEKQLREGQVF-TEYEQITKKreGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRM
| |..  . . . ..|......  .  .   |  .|...||.|.. ...| |. |. ....    ||||| |.     .  .||.||||..|||.|.||.
ikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk..kyivaqgPlkntvadfWrl

VWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLE
..|  ...| |||||.|.||.|| .|||. ..   .. |||.| |. . ..    ||.  |..     . |.||| ..|  |||..| |.    .||...
iveekvstivmltklveggkdkCrqYWpeskt...ekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

EFQSvcrHANSMNEVevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
. |    . .. ..|    | .|||||||||||| . |||..  |.. |.... ...  ||..|| ||||  ||.|.. || . ..
rvqk...dqkkdkgv....pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1061-1315 1.9e-59 196.0 In-house 24-271 (274) alignment
Range on Protein: 1061-1315
Range on HMM: 24-271/274.0
KLPENVSRNRFKDVLPYEDCRVELSS--SHHNSGGYINASRVKVPvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDC
... . ..||.|..|| |  || |.|  |...   ||||  .| .  .|   |.|.|||. |||.|.|||...  .||| |||||||  ..|| .|.|| 
dvfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

TSPkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSgeQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFqsvcRHANSMNEVEVGPPpIVHCSAGVGR
..  . . ..| . .  .  ..   |    |.|... .  .|.| |  | |||..  |||.. .|....|     ..... .. ...|  .||||||.||
edy.eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvlev....eesreeenaklapv.vvhCsaGiGr

TGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNT
||. . ..| .  |.... ... |..  ||..|  ||||  || ....||.. ||..
tGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl

subfamily_PTPN1_pd Subfamily PTPN1 1045-1313 2.9e-59 195.2 In-house 12-272 (290) alignment
Range on Protein: 1045-1313
Range on HMM: 12-272/290.0
YEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHnsgGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLK
|..|.|. .   . ..||||| ..||..|| ||. .|..| ...     ||||| |... |    .|| .|||. |||. .|.||||  .. . || |. 
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakr..syiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EDGKEKCFKYWPDCTSPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEfqsvCRHANSMNEvEV
| .. ||..|||   . |. . |   ..|     ...  |. . | |  . . | |.. |  |  ||. | |.    ||.|| .    .|.. |... .|
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfk....vresGslss.dv

GPpPIVHCSAGVGRTGVLLLVDIMISSLEHNEE---INIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|| ...|||||.||.| . ||| ..  .|....   ..| |..  ||..|. ..||  |  | | |...  |
Gp.avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak

subfamily_Ptp69D_pd Subfamily Ptp69D 1040-1313 1.8e-58 193.1 In-house 23-287 (307) alignment
Range on Protein: 1040-1313
Range on HMM: 23-287/307.0
QVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIA
 .  |||.. ..     . .|.  ||  .||..|. .... || |.    ...  ||||| .|     |  ..||||.|.|.|..|.|||..|   ..| 
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikg..ykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTKLKEDGKEKCFKYWP-DctspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-----SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSV
||..|.|  ..|| |||| .      .. ..|   |    ..  . ||   | . ..        ..| |   .|. |..   |.  .| | ..|. ...
mlsnlteknrkkcakYWpie......devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

CRHAnsmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
 ..           | .|||||||||.|... .|...  |. .....| ...  ||.|| |.||   ||.|.|.||..  .
ykln........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1041-1313 2.8e-57 189.2 In-house 25-284 (319) alignment
Range on Protein: 1041-1313
Range on HMM: 25-284/319.0
VFTEYEQITKKREGaVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
.  |.... .  .    .... .|| ..||....|.|. .|| ||. .  ..  ||||| .      |   .||.|.|.|||..|.|||||| .. .. |
lekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg..yqerekfiatqaPlentiedfWrmvWeeessivvm

LTKLKEDGKEKCFKYWPdctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSG-EQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvcrhaNS
||||.| .| |. ||||     ..|  |.| . |  .  .    || . |.|..  |  | |.| | ||..||... |..  . | .|.. .      .|
ltklveklkvklkkywp.....eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir......ks

MNEVEVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
... . | | .|||||||||||  . .|.|.  ..... ... ...  || || .|||.  ||.|.|.||.. ..
rektqsg.PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1042-1313 6.6e-57 188.0 In-house 33-291 (298) alignment
Range on Protein: 1042-1313
Range on HMM: 33-291/298.0
FTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAML
| . ...... | .    .. ||| ..||. |..... .|| |.. .  . . ||||| ..     .   .||.|.|...||.|.||||.|   ..| ||
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVml

TKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMn
|.|.| .| |. |||||     ......| ..|  . ... . .|.  |.. .  . ..|.| .|..  ||..| |   .  | .|.. .   ..|    
tnleeldktkyhkywPd.....egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk.

evevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
      | ||.|||||||.|    .| ..  ..... . . ... .||..|. .|||  ||.|.|.| .. |.
......pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_PTPN23_pd Subfamily PTPN23 1029-1314 8.4e-57 187.2 In-house 8-282 (288) alignment
Range on Protein: 1029-1314
Range on HMM: 8-282/288.0
RKILEKQLREGQVFTEYEQITKKReGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSsshHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRM
|| |. .   ...| | ||  .|       ..    ....||..|.|||.  || |     .   ||||| ||  ..    ..||.|.|...|..|.|.|
rkmldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkd.lspgcPdfiatqaPlqstlnDFWlm

VWESGTQVIAMLTKLKEDGKEKCFKYWPDctsPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEE
|.|  ..|| ||.. .| ||.|. .|||     | .| .||...|  .  .... ..   |.|.. .. . ..| |||.. ||. | |.  . .| ||.|
vyeqkssviVmllskeelgkpkvdrYwPe...dkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

FQSVCRHANSMNEVevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE-INIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
 .|  .. .   ..    | .||||||||||||. ||   .  ||...  ..|....  ||.||  |||.. |. |.|.| ..  ..
vesayeavqrkskt....PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_PTPRG_pd Subfamily PTPRG 1043-1313 6.7e-56 184.7 In-house 23-288 (563) alignment
Range on Protein: 1043-1313
Range on HMM: 23-288/563.0
TEYE--QITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSG--GYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIA
 |.|  | . . .   . .|. |||  .||  ....|.  ||.||.   . .   ||||. ..    ..   .||.|||...|..|.|||.||  ...| 
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk..afiatqgplkdtfddFWrmiWeqnvaiiv

MLTKLKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQ----RTVWHLQYNDWPNQGCPDDVHGFLSFLEEFqsv
|.|.|.|.|..||. |||       .. ..| ..|  . ..   .| .  |....  .  ..|    ..| . .| .||..| |.     |.| .     
mitnlvergrrkcdvYWPk.....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks...

crhaNSMNEVEVGPpPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
    .  |. |.||  .|||||||||||... .| ..  ..... .|. ...  .| ||  .|||  ||.|...||.. ..
....saankaeaGP.ivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1043-1313 9.6e-56 183.8 In-house 11-296 (297) alignment
Range on Protein: 1043-1313
Range on HMM: 11-296/297.0
TEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNSgGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
.|.. . ....|    ..| .  . .||..|.| ..| || |  .  ..  ||||  |  |   . |.|| ||||...||.|.|..|.| . .||.|..|
aekdllldeargesfssakrnsslrknryrdilatddtrvkllrviter.dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

LKEDGKEKCFKYWPDCTSPKKNTAEFGpFRVIAQFSNDSGCYITSGLTLRHVpsGEQRTVWHLQYNDWPNQGCP---DDVHGF--------------LSF
|.|||..||. |||..   .......     ....|..    | . |.| .    |.| | | |.  ||. | |   .|.  |              |. 
lqedGrdkcapywpsvvqerlkagdvv.veflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlal

LEEFQSV-CRHANSMNEVE-VGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
.| | ..     .|..       . .|||||||||.||..| |.... | ..   ..  .. |||.||  .|||. |....|.| .. ||
vemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1061-1313 4.4e-55 181.9 In-house 47-285 (297) alignment
Range on Protein: 1061-1313
Range on HMM: 47-285/297.0
KLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVPVAgellHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKeKCFKYWPDCT
.   | ...|.|..|||.  ||.| .  .. .  |.||| ||.       ..|. | ||..||.|.|.||..  ...|.||....|  | || .||.| .
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

SPKkntaeFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPD--DVHGFLSFLEEFQSVCRHANSmnevevGpPPIVHCSAGVG
. .     ||   |. .  ..   .|   |....  .  .| |   |. .||..  .   ... .| ...| . .  . ..      | | .|||.||||
vtt.....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae......g.PllvhclaGvG

RTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|||||| .| ...  ....|..| ...  |||.|. .|||  ||.|||.|... | 
rtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1061-1313 5.7e-54 178.0 In-house 5-243 (250) alignment
Range on Protein: 1061-1313
Range on HMM: 5-243/250.0
KLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVPVaGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEkCFKYWPdct
| |.|  .||. |..... .|| | ...  .   ||||| ...   ..   .||.|||...|..|.||||.|  ...| |||.||| .|. . .|||   
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP...

spKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMnevevgpPPIVHCSAGVGRT
   ... ..|  .|    ..  . |..  | | .    ..|.| .|..  ||..| |.  .  | .|.. |.  ..|..        | ||.|||||||.
..vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna.......PvivqCsaGvgrs

GVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|  . .| ..  |.... ... |.. .||..|. .|..  || |||..... |.
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPRA_pd Subfamily PTPRA 1044-1310 7.5e-54 177.8 In-house 37-293 (330) alignment
Range on Protein: 1044-1310
Range on HMM: 37-293/330.0
EYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
|.. .   .  |.. ...  ||  .||. ..|||.  || ||  . ...  ||||| ..     |  ..|||||| |.||.|.|||.||  .. | |||.
efnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidG..ykekdkfiaaqGPkeetvedfwrmiweqksativmlte

LKEDGKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGE----QRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcrhans
|||  .||| .||||     . .  .|  ||  . .. .  |    . ....| .     .| |  . .. ||. | | .  | |..|.. ..       
lkerkeekcaqywPd.....eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk.......

MNEVEVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.|... | | .||||||||||| .. .| ..  .. .. ... ...  ||.||  ||||  ||.|.||.| .
lnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1065-1314 5.4e-53 174.8 In-house 43-280 (515) alignment
Range on Protein: 1065-1314
Range on HMM: 43-280/515.0
NVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkk
| ..||.|..|||.  || |   . |    |.||| ..         |||.||| . .|.|.||.|..  .  |||.|||||. | || |||||  .   
nfkknryknilPydsvrvklevindnPhsdyfnasyips..fdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg...

NTAEFGPFRVIAQFSNDSGCYITSglTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcrHANSMNeVevgpPPIVHCSAGVGRTGVLL
.. .|| ..|     .  .  |    .|. . . . |||   ....||..| | .   .| .. | ..     . ..      | |.|||||||||||..
dsvkfGsikvelvsleactggikr..kltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka...dhgqyt.h....pliihcsaGvGrtGvvi

LVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK--N
 .| ...  .  . ... ... ..||.|. .|||  ||.|.| |. . |.  |
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1060-1315 1e-52 174.0 In-house 39-282 (315) alignment
Range on Protein: 1060-1315
Range on HMM: 39-282/315.0
SKLPENVSRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDC
.. ..| ..||.|..||..  || |     .    ||||| .|     .   |||.||| . .|.|.||||... .  |.|.||..|. | || .|||| 
aretinfkknryknilPldsarvkleviddsPdsdyinasyiks..vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

tspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVcrhaNSMNEVEVgpppIVHCSAGVGR
   | ...||| ..|     .  .  ..  |..|.  | |.|||   |...||..| . ..  .| .. | ..     | ..|  .    .|||||||||
...kadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad....ngkkefsl....lvhcsaGvGr

TGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK--NT
|||.. .| ... ..... ... ... .||..|. .|||  .|.|.| |. . |.  ||
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1039-1313 6.6e-52 171.1 In-house 10-278 (287) alignment
Range on Protein: 1039-1313
Range on HMM: 10-278/287.0
GQVFTEYEQITKKREGAVCYT--SKLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQV
 .|  |......  |..      ..   .|..||. ||||..| || ||   .    ||||  |      |   .||||||.  ||.|.||.|.|  . .
ddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytdde..afiaaqgPiaatvrdfwravletrsas

IAMLTKLKEDGKEKCFKYWPDCTSPKKntaeFGPFRVI-AQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRH
....|.  |... ||.||||.   | .     | . |.  .... .  | .  | | .. . | | |  |.. .||... .    |.. |  . .     
vitmtreveearlkcykywPerevPmr....vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

ANSMNEveVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
| . .|  || |..||...|.||.|.|| . ...| ||   .... ...  ||..|  .||.| |. ..|.||.   |
ardase..vG.PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_PTPRK_pd Subfamily PTPRK 1044-1310 7.5e-52 171.1 In-house 27-275 (314) alignment
Range on Protein: 1044-1310
Range on HMM: 27-275/314.0
EYEQITKKregavCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
||| . .        ..|  || ..||..|.|.|. .|| | . . . |  ||||. .         ..|..|||...||.|.||.|.. ..  | |||.
eyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalids..ykrpaafivtqgPlqetvkdfWrlvydencasivmlte

LKEDGKEKCFKYWPDctspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHansmn
|.| |. || ||||.      .|  .|...|    ..    ...  .....   .  |.|.| ..|.  ||. . |   .|.|... . ..   .     
lvevgrvkClkyWPe......dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.....

evEVGpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
  | | . .|||||| ||||. . .||..  .|... ... ...  ||.... ||.|  ||.|.| ....
..eaG.rivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1040-1310 4.6e-50 165.7 In-house 35-289 (319) alignment
Range on Protein: 1040-1310
Range on HMM: 35-289/319.0
QVFTEYEQITKKR-EGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVI
..  |. ...|.  ..|    . |..|  .||. ..|...  .| |      .   ||||| |.     .   |||||||..||..|.|||.||. .  |
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd..kyiaaqGPldntladfWrmiweyncsti

AMLTklkedgKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHA
 .||      |.|| .|||      |   . . | |  .  ...  |.   . | .     ..| .    .  ||..| ||    .. ...  . . .. 
vllt......kdkcsqywpl.....kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

NSMNEVevgpppIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
|  ...      .|||||||||||| . .|.... ..... ... ...  |||||  .|| . || |.| ||..
nhrani......vvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1045-1310 4.7e-49 162.4 In-house 4-253 (284) alignment
Range on Protein: 1045-1310
Range on HMM: 4-253/284.0
YEQITKK-REGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH-NSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTk
. ...|.  .|.    . |..|  .||. ..|...  .| |      .   ||||| ..     .   |||.|||..||..|.|||.||. .  | .|| 
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd..kyiatqGPldntladfWrmiweyncstivllt.

lkedgKEKCFKYWPDctspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRH-VPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMNE
     |.|| .|||      |   . . |.|  .  ..|  |.   . | .     ..|..    .  ||..| ||    .. ...  . . .. |  ..
.....kdkcsqywpl.....kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhran

VevgpppIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.      .|||||||||||| . .|.... ..... ... ...  |||||  .|| . || |.| ||..
i......vvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1049-1314 3.5e-47 155.6 In-house 30-285 (290) alignment
Range on Protein: 1049-1314
Range on HMM: 30-285/290.0
TKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELS--SSHHN-SGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKE
 .  .    ..   ..|  .|||.....|.| |. |   |.|.. .  ||||. .|     |  .|||.|||..||. |.|...|.  . .| |||. .|
dsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg..ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniie

DGKEKCFKYWPDCtspkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPS-GEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANsmNevev
.||.|| .||||      .|...|.|..  .  .    ||.  | ...  | |....| ..|   |...|   . .. |. .|| .   |.    |    
egkvkCqqYWpds.....dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..n....

gPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
  . .||||..|||..|.. ... |   . .  |.. ...  .|.|.. .|||| || .... ....|..
.tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPRN_pd Subfamily PTPRN 1039-1312 2.2e-46 153.0 In-house 29-292 (297) alignment
Range on Protein: 1039-1312
Range on HMM: 29-292/297.0
GQVFTEYEQITKK-REGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQV
 ..  |.| ...   | ... ..| ..||..|| |.||||.. ||.|.. . ...  ||||| .          |||.|||. .|| |.|.||||.|. |
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvv

IAMLTKLKEDGKEKCFKYWPDCTSPKKNTAEFgpfRVIAQFSnDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHA
| .||.|.|.| ..| .||||  |   .  |    .....    .  |.   . |. . . | |||  . .  ||..|.|   . .| |    .   |  
ivnltrleeegvkqckrywpdeGsevyhiyev...hlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

NSmnevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEH-NEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
 .        | .||||.|.||||| .|.|.... | .   ||.|   .  ||.||  .|.|  |. |...|... .
sc........pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1058-1311 4.8e-46 152.1 In-house 42-278 (315) alignment
Range on Protein: 1058-1311
Range on HMM: 42-278/315.0
YTSKLPENVSRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWP
 ..|  ||. .||. ....|.  ||.|     ..   |.||. ..        .|||||||  ..|.|.||.|.|     | |||.| |. |.|. ||||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidG..ynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

DCtspkknTAEFGPFRVIaQFSNDSGCYITSgLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLeefqsvcRHANSMNEVEVgPPPIVHCSAGV
|          .|.. |  . |..    .|   ||  |   . |.|  |.|  ||. | |     .. .        |...  .. .|  . .|||||||
dk......kviyGkitvt.rkseevnteytv.rtlsvvfgdnirevvqlhytswpdmgvpkytiplmnli.......rtvkqhhtnsv.gaivvhcsaGv

GRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
|||| .. .| ..  .| .. |.. ...  .||.|. |||.. || |.|.||...
GrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1042-1314 1.2e-45 150.7 In-house 26-280 (287) alignment
Range on Protein: 1042-1314
Range on HMM: 26-280/287.0
FTEYEQITKKREGAVCYTSklPENVSRNRFKDVLPYEDCRVELSSSHHNsggYINASRVKvpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLT
||  ||.|....      .  ..|  .||....|.... || |   |..   ||||. ..     |  ..|.|..|| ||....|.....   ..| ||.
ftvleqvtqredevthnia..sqnkdknRltqilvpdnyrvllkgehpd...yinavfid..gykekkafiiaesPmfntarnfWkliddrnvtaivmlc

KLKEDGKEKCFKYWPDCTSpkkntAEFGPFRVIAQFSNDSGCYITSGLTLRHVP-SGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVC-RHANSm
..||. .|.|..|||. .|       .|....     . .  ||   | ...   .|....|   |. .|...|   .    |  .||      ...|. 
qekendeevcyqyWpeeks.....vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt.

nevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
       . .||||..|||..... ... |   . .  |.. ...   |.|.. .|||| ||.|........|. 
.......sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1042-1310 3.2e-45 149.2 In-house 12-265 (283) alignment
Range on Protein: 1042-1310
Range on HMM: 12-265/283.0
FTEYEQITKKREGAVCYTSKlpENVSRNRFKDVLPYEDCRVELSSSHHnsgGYINASRVKVPVAG-ELLHYIAAQGPMENTVQDWWRMVWESGTQVIAML
.  .....     |.. ...  ||   ||.....|..  |||| |  .    ||||. . |     .   ||.||.|...||.|.|.||..     | ||
revlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TKLKEDGKEKCFKYWPdctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQR-TVWHLQYNDWPNQGCPDdvhgFLSFLEEFQSVCRHANSM
|||.|| ..|| .|||     |. . ..|.| |  .    |  .|   |.||.  | ..   . | |..|| . |        .  |  |  |    .  
tklqedlrikCsqyWP.....krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa....iinslvkfnkvislqtes

NEvevgPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI-Q
..     | .||||.|.|||.|.. .   .  .  .  ....... |.|.||| .||| .|| .|... . |
kk....gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1034-1312 3.9e-45 149.4 In-house 17-288 (325) alignment
Range on Protein: 1034-1312
Range on HMM: 17-288/325.0
KQLREGQVFTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMV--W
|. .. . |.   ...   .|    .. .|||...||||.|....  || | . .   |  ||||| ..  .  .   ..||| |. .|..| ||.|  |
kkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdv..flaaqaPltatindlWrlvldW

EsgTQVIAMLTKLkEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQ
.  . |. .| .| . ||..| .|||.  .   .. .||...|  .  ..   |.   | .. |  || |.|  .|.  |.. | .     ..|.|.  .
r..csvvvvlnel.dlgkdrcavywpkemg...ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

SVCRHANSmnEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
 |    ..  . .   | .||||||||||||.. .  ..  . .. ...| ...  ||..|  ||.|| ||...|.||.. .
avservta..ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1064-1309 1.2e-42 140.8 In-house 2-236 (237) alignment
Range on Protein: 1064-1309
Range on HMM: 2-236/237.0
ENVSRNRFKDVLPYEDCRVELSSSHHNsGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
||  .||. ..  |. .|| |  .  .   ||||. .|  . |   .|||||||.|.. .|.|.|||.    || ||| | |  ..|| ||||.   |. 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

ntaeFGPFRVIAQFSNDSGCYITSG-LTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANsmneveVGPPPIVHCSAGVGRTGVL
    .| . |  .  ..   |     |. ...   | | ..  |.  ||..| |.    .| |  .     .| .         | |.||||||||||..
....ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvs......esgpwiihcsagvgrtgif

LLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
|..| |.   . .. ..| . .  . ..|  ..||  || |......
lvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

0051429 (Phosphotyrosine protein) phosphatases II 1091-1312 5.6e-42 139.6 In-house 3-225 (272) alignment
Range on Protein: 1091-1312
Range on HMM: 3-225/272.0
SGGYINASRVKVPvagelLH------YIAAQGPMENTVQDWWRMvWESGTQVIAMLTKLKEDGKEKCFKYWP-------DCTSPKKNTAEFGPFRVIAQF
 .|||||. |. .      .      .....||...|..|.||. .| |  .| .|... | |..||..|||       .. .    | ..| .||. ..
lsgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

SNDSGCYITSGLTLRHV-PSGEQRTVWHLQYNDWPNQGCPDDVhgFLSFLEEFQSvcrhansmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNE
     .||   |.|... . || |.|.||.| |||  | |..   .|..||....             | | .||||||..|||.. ......  .... 
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.............ggpvlvHCsaGkdRTGtvvallllllgvslet

EIN--------IPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
 ..        . . .  ||.||. .||| .|| |.|.||.. |
ivddYlltnlyleeaveelraqrpgavqteeqylflyeallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1041-1313 1.7e-38 127.2 In-house 21-280 (439) alignment
Range on Protein: 1041-1313
Range on HMM: 21-280/439.0
VFT-EYEQITKKREGAVCYTSKLPENV--SRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVWESGTQV
.|. ..|.|   .    | .| . ..   ..||.||| ...  || |          ||||  .|     .|  |||.||| ..|..|.||.|.|  |  
ifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl..yiatqgpkkettddfwrlviekktvt

IAMLTKLKEdgkekCFKYWPdctspKKNTAEFGPFRVIAQFSNDSGCYITSGLTLR--HVPSGEQRTVWHLQYNDWPNQGCPDDVhgflSFLEEFQsvcR
| |||.| |      .||||      .. . .|   | ..   .   |.  |. .   .  .  .||| ...|  ||..  | .     |.. .|    |
ivmltnlve.....sykywp.....sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa....shvldfl...r

HANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
  || |. |   | .||||||||||| .. .|| .  |  .....|  .. .||.||  |||.. || |.|.|... ..
ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1043-1313 2e-38 126.8 In-house 19-294 (301) alignment
Range on Protein: 1043-1313
Range on HMM: 19-294/301.0
TEYEQITKKrEGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHH---NSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAM
 .|...... |   |  .   ||   ||||.. .|.| |. |.  ..    .  ||||| ..     |  ..|||||||..|..|.||..|.  .. | |
eqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg..ysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LTKLKEDGKEKCFKYWPDCTSPKKNTAEF---------GPFRVIAQFS----NDSG-CYITSGLTLRHVPsgEQRTVWHLQYNDWPNQGCPDDVHGFLSF
.|.|||. |.||..|||...  ...  .|          |  || |..    . |.  || . .  ..    . ..|  ||  |||..|   . .  |  
vtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqv

LEEfqsVCRHANSMNevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
...   |    ....    | | .||||..|.|.||   |.| .     .  ... ..   .|.... .|.|  |||..|... . |.
idd...vihrqqkig....ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

0041856 (Phosphotyrosine protein) phosphatases II 1065-1311 4e-38 126.2 In-house 1-170 (182) alignment
Range on Protein: 1065-1311
Range on HMM: 1-170/182.0
NVSRNRFKDVLPYEDCRvelssshhnSGGYINASRVKVPVAGELlhYIAAQGPMENTVQDWWRMVWESGTQVIAMLTklkedgkekCFKYWPdctspkkn
|...||..|.|||.  |            ||||. .  .  .    .||.|||. .|| |..||..| | ..| .||         .. |||        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

taefgpfrviaqfsndsgcyitsgltlrhvpSGEQRTVWHLQYNDWPNQGCPDdVHGFLSFLEEFQSvcrhansmneveVGPPPIVHCSAGVGRTGVLLL
                               . ..|......|  ||  |.|| .. .|.|.|| ..             | | .|||||||||||.| .
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevle............eggpvlVHCsaGvgRtgtlva

VDIMISSlehneEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQS
 ..|..      ...... .  .|..|. ||.|  || |.. || . 
aylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_CG7180_pd Subfamily CG7180 1042-1309 4.2e-38 125.7 In-house 19-287 (296) alignment
Range on Protein: 1042-1309
Range on HMM: 19-287/296.0
FTEYEQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHNS-GGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAML
.    ..|.. |   | .    ||  .||  .|.||.  || |.. . ..   ||||. |   .  .   ||  ..|...||...||.|.. ... . .|
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk..eyivteapkketvdefWrlvydeeisavvvL

TKLKEDGKeKCFKYWPDCTspkknTAEFGPFRVIAQFSNDSGCYITSGLTLR----------HVPSGEQRTVWHLQYNDWPN-QGCPDDVHGFLSFLEEF
||  .  | .. .|||  .      ...|.. |    ..      .  . |           .  . |.|.| ..|.  |.  . .|    ... ...  
tktfdfak.mypsywpnks.....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

QSVCRHAnsmNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
... ...   .| ..  | .|..| |..|.|| | .|. .  .|..||... ...  ||..|  .|..| .| ..|  | 
rlwrekv...dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1065-1309 6.2e-38 125.3 In-house 7-237 (239) alignment
Range on Protein: 1065-1309
Range on HMM: 7-237/239.0
NVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
| ..||. ... |.  || |   |      ||||| ..    |    |||.|| .| .  |.|||.|.    || ||| | |  |.||..|||| ||   
nkaknryanivtydhsrvvleklsndphsdyinasylrd.ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

NtaefgpFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFleefqsvcRHANSMNEVEVGPPPIVHCSAGVGRTGVLL
|      .||  . ..    ||   . . .|   |.| |.. ..  ||..| |.     | .        |.  . . .    | ..|||||||||| .|
n......lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl........rrkitkdslpgarpwvihcsagvgrtgafl

LVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..| |.   .... ..| . .  .|..|  ||||  || |.. |..
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1065-1309 8.4e-38 124.9 In-house 8-238 (239) alignment
Range on Protein: 1065-1309
Range on HMM: 8-238/239.0
NVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
| ..||. ... |.  || |   |      ||||| ..    |    |||.|| .| .  |.|||.|.    || ||| | |  |.||..|||| ||   
nkaknryanivtydhsrvvleklsndphsdyinasylrd.ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

NtaefgpFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFleefqsvcRHANSMNEVEVGPPPIVHCSAGVGRTGVLL
|      .||  . ..    ||   . . .|   |.| |.. ..  ||..| |.     | .        |.  . . .    | ..|||||||||| .|
n......lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl........rrkitkdslpgarpwvihcsagvgrtgafl

LVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..| |.   .... ..| . .  .|..|  ||||  || |.. |..
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1059-1312 1.1e-37 124.4 In-house 39-236 (392) alignment
Range on Protein: 1059-1312
Range on HMM: 39-236/392.0
TSKLPENVSRNRFKDVLPYEDCRVEL-SSSHHNSGGYINASRVKVpVAGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGkekcfkywpd
... . |. .||.|..|||.  || |      .   |.||| ..  .  |   |||.|||   ...|.||||..  .  |||.|||||            
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.fdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

ctspkkntaefgpfrviaqfsndsgcyitsgltlrhvPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcRHAnsmnevEVGPPPIVHCSAGVG
                                        ..|||   .. .||... |  .  .| |..| ..   .       .   | |.|||||||
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevka..dfG......qythpliihcsagvg

RTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
||||.. .| ...  ..   ... ...  .|..|  ||||  ||.|.| |... |
rtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

0036282 (Phosphotyrosine protein) phosphatases II 1093-1306 3e-36 120.1 In-house 3-164 (174) alignment
Range on Protein: 1093-1306
Range on HMM: 3-164/174.0
GYINASRVKVPVAGEllHYIAAQGPMEntvqdWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDctspkkntaefgpfrviaqfsndsgcyitsgltlr
 ||||| ... .  .  ..|| |||..      |.|..| | ... ||...||.|..||. |||.                                   
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

hVPSGEQRTVWHLQYNDWPNQGCPDDVHgFLSFLEEFQSVCRHansmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEhNEEINIPKMMGILRQQRM
  .. . |......|  ||  |.||.   .|.|... .... .         | | .|||||||||||.| . ..|.  |. .  ... ...  ||.||.
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.......dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

LMVQTVGQYTFVYK
 |||| .|| |.|.
gmvqtpsQyrflyy

0049772 (Phosphotyrosine protein) phosphatases II 1056-1314 6.6e-35 116.7 In-house 37-282 (314) alignment
Range on Protein: 1056-1314
Range on HMM: 37-282/314.0
VCYTSKLPENVSRNRFKDVLPYEdCRVELSSSHHNSGGYINASRVKVPvagelLHYIAAQGPMENTVQDW----------WRMV--WESGTQVIAM----
 .....|..| ..||..|.||.. .|| |.. .... .||||| |. .     | .||.|||.|.|| |           ||||  ..  . .| |    
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTKLKEDGkekcfK-----YWPDCTspkkntaefgpfrviaqfsndsgcyitsglT---LRHVPsgeQRTVWHLQYNDWPNqG
                 |..| . |           ....                                .    .. .   .|.. .. . ..|  |
vladelsrLdaAlgKtpllildgng.....neptaadlellk..............................eelydpelf...erlgikylripvpD.g

CPDDVHGFLSFLEEFQSVcrhansmnevEVGPPPIVHCSAGVGRTGVLLLVDIMISSLehneEINIPKMMGILRQQRM-----LMVQTVGQYTFVYKALI
....   |..||| ....          . | | .|||.||.||||.......... |     ... . .  .|..|.      ....  || |...|| 
saplledfdeflefieea..........dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileall

QSLKN
. ||.
eylkf

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1066-1312 5.3e-34 112.2 In-house 57-283 (290) alignment
Range on Protein: 1066-1312
Range on HMM: 57-283/290.0
VSRNRFKDVLPYEDCRVELSSShhNSGGYINASRVKvpvaGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNT
. .||.|||   .  || |.      | |. |  ||    |    .| .||....|| | |||| . .. .| || .| |||| || .|.|.      ..
fkknrykdvvcndktrvilkdG..ydGdyvhanyvk....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG...ev

AEFGPFRVIAQFSNDSGCYI-TSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVhgfLSFLEEFQSVcRHANsmnevevGpPPIVHCSAGVGRTGVLLL
  || . |.   ..|    |    |..|.. || .  . ||.   ||..  .      |..|  .... |.|.       | | .||||||.|||| .  
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlril.rkas.......G.pvvvhcsaGiGrtGtfva

VDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
... .  | .  |... ...  ||. |.  ||   ||  . ..|..  
ievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG

0043147 (Phosphotyrosine protein) phosphatases II 1091-1305 1.6e-33 111.2 In-house 4-154 (172) alignment
Range on Protein: 1091-1305
Range on HMM: 4-154/172.0
SGGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLkedgkekcfkywpdctspkkntaefgpfrviaqfsndsgcyitsglt
.  ||||| .....     ..|| |||. ||. | |||..| | ..| .||.|                                               
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

lRHVPSGEQRTVWHLQYNDWPNQGCPdDVHGFLSFLEEFQSVCRHANsmnevevGPPPIVHCSAGVGRTGVLLLVDIMIsslehnEEINIPKMMGILRQQ
  . |....|......|  || .|.| .   .|.|||  ....   .       | | .|||||||||||.| . ..|.      . ... . .  .|..
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp.......ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrek

RMLMVQTVGQYTFVY
|. .||. .|| |.|
Rpgavqnpsqyrfly

0046846 (Phosphotyrosine protein) phosphatases II 1094-1312 5.1e-33 109.7 In-house 14-173 (176) alignment
Range on Protein: 1094-1312
Range on HMM: 14-173/176.0
YINASRVKVPvagellHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKntaefgpfrviaqfsndsgcyitsgltlrh
||||. .  .      ..|| |||...|..|...|..| | ... .||...| |. ||. |||......                               
yinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

vpsgeqrtvwHLQYNDWPNQGCPDDvHGFLSFLEEFQSVCRHansmnevevGPPPIVHCSAGVGRTGVLLLVDIMISslehNEEINIPKMMGILRQQRM-
          . .. .||  |.||.   .|..||. ... ..         | | .||||||.||||.|.. .....    .  ... . .  .|.||. 
..........qylhlpwpDhgvpdl.elllellefirealke.........ggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRpl

LMVQTVGQYTFVYKALIQSL
 .||| .|| |.|... . |
gavqtpeQyrflyefellll

0049260 (Phosphotyrosine protein) phosphatases II 1109-1306 1.7e-32 107.6 In-house 9-144 (152) alignment
Range on Protein: 1109-1306
Range on HMM: 9-144/152.0
LHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWpdctspkkntaefgpfrviaqfsndsgcyitsgltlrhvpsgeqrtvwHLQYN
 ..||.|||..||. |.|||..| | ..| |||.| |.||.|| .|.                                                . .. 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylhl

DWPNQGCPDDVHGFLSFLEEFQSVCRHANSmnevevgpPPIVHCSAGVGRTGVLLLVDIMIsslehnEEINIPKMMGILRQQRMLMVQTVGQYTFVYK
 ||  |.||.   .| .|.  .  ... .         | .|||||||||||.| . ..|.        ... . .  .|..|. .|.. ||. |.|.
pwpDhgvpdlsqlllflllfieklaldkgg........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

PTPc_DSPc_SM00012 1201-1309 5.3e-31 102.3 In-house 1-104 (105) alignment
Range on Protein: 1201-1309
Range on HMM: 1-104/105.0
TVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEHN-EEINIPKMMGILRQQRMLMVQTVG
|| |..|..||..|.|.... .|..|...... ....|      ..| .|||||||||||.. ..||....||.. .|..| ...  ||.||. ||||  
tvkhyhytgwpdhgvPeesdsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

QYTFVYKALI
|| |.|.||.
qylflyrall

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1046-1309 6.4e-31 102.0 In-house 18-266 (281) alignment
Range on Protein: 1046-1309
Range on HMM: 18-266/281.0
EQITKKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSS--SHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKL
 ..       .| . . | |  .||. ..   .  ||.|      .||  || |  .. |.      || .||| ..|  |.|||.|.  |  | || ..
snlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkr..gyiltqgpkketradfwrmiwqenttaivmlcqf

KEDGKEKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvcrhANSMneve
 |  .||| .|.|  .   .   .|  . |  . |      .|. | | .   || | . |  ...||.   |.    .|  | . .     | |     
letnrekcaeyfprna...hcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkir.....arst....

vgpPPIVHCSAGVGRTGVLLLVDIMISSLE-HNEEINIPKMMGILRQ-QRMLMVQTVGQYTFVYKALI
   ||..||||||||.| |. |.| . |.  |    .| ...  ||   |   |||. || ...| |.
...ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1059-1312 6.6e-31 102.4 In-house 37-271 (288) alignment
Range on Protein: 1059-1312
Range on HMM: 37-271/288.0
TSKLPENVSRNRFKDVLPYEDCRVELSsshHNSGGYINASRVKvpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPdc
 ..  .| .|.|....   . .|| ||    ..  ||.|  |    |    . | || |.. |..  |.|. ||. . | ||..| | ||||  .|.|  
idsfianptrdryenlprcditrvkls...ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP..

tSPKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRT-VWHLQYNDWPNQGCPDDVHGFLSFLEEFqsvcrhaN---SmnevevgpPPIVHCSA
 | . ..| .| .  . . ...    . .  .||    ||..  | .| ...|...| |..   .| .|| .       .            | .||.||
.sklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqk........Pivvhssa

GVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSL
|||||| | |. |.. ||  .. . |....  ||..|.  .||  || .|.. . . |
GvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1041-1310 7.6e-31 102.2 In-house 18-275 (307) alignment
Range on Protein: 1041-1310
Range on HMM: 18-275/307.0
VFTEYEQITKKREGAVCyTSKLPENVSRNRFKDVLPYEDCRVELSSSHhNSGGYINASRVKVPVagELLHYIAAQGPMENTVQDWWRMVWESGTQVIAML
.  |.....||   .|  .  .  |  .||..||   . .|. .  .   .  || |  . . .  .  ..|.||||.|||....| |. .   . . ||
lvdefrvlakktpegvt.veafsantdknryqdvkcqdkgrivvkfdg.lasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesviml

TKLKEDGKEKCFKYWPDCTSPKKNTAEFGPFRVIA-----QFSNDSGCYITSglTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEefqSVCRH
 |. | .| || .|||     |.  .| .    .|     ... |  .   .  ||. . ... ||. |||...||..|.|.   . . .||   .|  .
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvt..tlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle...avryd

ANsmnevevgpPPIVHCSAGVGRTGVLLLVDIMISS-LEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
 |         | .|||||||||.| .. . ..    ..  .  .. |..  ||.||   .||  || .... |..
tn.........pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_ptpA1_pd Subfamily ptpA1 1064-1274 9.5e-31 101.9 In-house 46-258 (418) alignment
Range on Protein: 1064-1274
Range on HMM: 46-258/418.0
ENVSRNRFKDVLPYEDCRVELSSSHHNSG-GYINASRVKVPVAgelLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPK
 | |.||. ..|| .  ||.|   . . |  ||||  .         ..|..|||. ||. |.||||||   ..| ||..  |. . || .|||.    .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

K-----NTAE-FGPFRV-IAQFSNDSGCYITSgLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvCRHANSMNEVEVGPPPIVHCSAG
.     |  | || . | . .  .|    | .   .|    || | . . ||. ||..  ||  . |  .|       |. . .   .   | |||||||
qfsiygngnevfgtysvelveviqdpereiit.rnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit..nrqnqiipssdrnvpiivhcsag

VGRTGVLLLVDIMISSLEH
||||| .    ||.  |.|
vgrtgtfctavimmkkldh

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1065-1310 1.6e-30 100.8 In-house 55-287 (305) alignment
Range on Protein: 1065-1310
Range on HMM: 55-287/305.0
NVSRNRFKDVLPYEDCRVELSSSHhnSGGYINASRVKVPVAGELlHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKN
....||..||   .   | |.        || |  | .|.  |   .|.||||...|....| || .   . | || |  | || || .||| .   |..
aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

TAEFGPFR-VI--AQFSNDSGCYITsglTLRHVPSGEQR-TVWHLQYNDWPNQGCPDDVhgfLSFLEEFqSVCRHANsmneVevgpPPIVHCSAGVGRTG
         |     .  |.   ||   .|.   ||.|. .| |||...||..| |      |. || . |  | ..    |    | .||||||.||||
lksgivvenvsgskpmerdaeiqit...llnltysgdqkmsvrhlqwtewpdrgvppck...ltslell.sairgsk....v....pivvhcsagigrtg

VLLLVDIMISSLEHNEEI-NIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
 .. .. ..  .  | .   .|...  ||.||   .|.  || |... ...
tivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1064-1317 2.6e-30 100.2 In-house 47-292 (305) alignment
Range on Protein: 1064-1317
Range on HMM: 47-292/305.0
ENVSRNRFKDVLPYEDCRVELSSSHHNsgGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKK
..  .||.|||   .. || | ..      || |  |  |   .   .| .| |.|.|  |.| | ..   . | || .|.| | .||..|..    .. 
qeagknrykdvgcldnnrvklegpwph..eyihanyvstptnpk..rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

NTAEFGPF-------RVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEfqsvCRHANsmnevevGpPPIVHCSAGV
.  | |          |  .| .|.   .|    .   | ...| | |  ..|||..| |      | .||.    .| .        | | .||||||.
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek....arpsk.......g.pivvhcsagi

GRTGVLLLVDIMISSLEHNEEIN-IPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKNTRL
|||| ..... ..  |   . |.   |..  .|.||   .||  || ||.. ... ... .|
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1043-1309 2e-29 97.2 In-house 31-287 (310) alignment
Range on Protein: 1043-1309
Range on HMM: 31-287/310.0
TEYEQITKKREGAVCYTSkLPENVSRNRFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTK
 .| ..  |.. .. | .   ... .||. ||.  ...|| |   .   . || |  ||     .   .| .|||.. |. |.|||...  .. | .| |
kqyrkldakqdssltyea.ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs..tficsqgplqhtiidfwrmifqeraesilllck

LKEDGKEKCFKYWPDCTSpkknTAEFGPFRVIaQFSNDSG----CYITSGLTLRHVPSGEQRT------VWHLQYNDWPNQGCPDdvhgflsflEEFQSV
  |.|. ||  |||        |  .|  ||  ..|. |     | ..  .    ||  || .      |  ... .||..| ||         |  ..|
vgeegrpkcvgywpslgv....tetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtv

CRHanSMNEVEVGPpPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
 .    . .|  ||  .||||||..|..|.. ... |  |.. ..... ...  |...|.  .||  ||... .  |
pqr..llaqvrhgp.cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1042-1310 8.1e-29 95.4 In-house 12-257 (267) alignment
Range on Protein: 1042-1310
Range on HMM: 12-257/267.0
FTEYEQITKKREGAVCYTSKlpENVSRNRFKDVLPYEDCRVELSSSHHNsggYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLT
| . ..|....    .. ..  .|  |||. |.|||.| || |. . ..   ||||| |.    ..  ..|. |.|..||. |.. .. . .  || .||
felikkisdtsstisqsiae..knqernrlddnlpyddtrvilrtkeee...yinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivllt

KLKEDgkeKCFKYWPDCTSPKKNTAEFGPFRVIAQFSNDSGcYITSGLTLRHVpSGeqRTVWHLQYNDWPNQGcpdDVHGFLSFLeefQSVCrhanSMNE
|  .|   .  ..||      |.  ..   . . .  ||    ||  | ..   |   . |    |. |  .    . . .|  |     .     . |.
kvftd...nirlfwPPkmgqakkyqdltvehslekeendyq.iitlelkfkne.sa..hnvtlyyykkwnint...nnkpylkpl...fgil....aknq

VEVGPPP-IVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
.| | .| .|.||.||||.| .| .| ..  . ...  .| ...  .|.||. .|.|  .| .... | .
lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1069-1313 3.3e-27 90.0 In-house 47-277 (312) alignment
Range on Protein: 1069-1313
Range on HMM: 47-277/312.0
NRFKDVLPYEDCRVELSSSHhNsgGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkknTAEF
||. ..  ..  |  |.    |   || |  ||.    |  .....|||.|||.  .|...   |.  | .|. . ||| ||| ||  |  .      ..
nrypniqcwdrgrftlagde.n..fyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg....fvdl

GPFRVIAQFS------NDSGCYITSGL-TLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLeefQSVCRHANsmnevevgpPPIVHCSAGVGRTGV
   || ...         |   ||  .  .    .|..  . | |.  ||..| || .   | .|    .| .  .         | | |||||||||| 
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll...savkkdkk.........pviahcsagvgrtgt

LLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
| |.. ||..| |    |. ... .||..|   |... || .. ..... | 
laliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly

subfamily_CG42327_pd Subfamily CG42327 1063-1233 9.1e-27 88.5 In-house 25-194 (319) alignment
Range on Protein: 1063-1233
Range on HMM: 25-194/319.0
PE-NVSRNRFKDVLPYEDCRVELSS-SHHNSGGYINASRVKVPVAGElLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTS
|     ..|. .|.|  . || | . . ...  |..|| |. .   .  .||||| ..|..  |.||.|||  ..||  ||.| | | ..| .|.|   .
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddap.nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

pKKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYnDWPNQGCPDDVHGFLSFLEEFQSVC
  .||  .| ..|  .  .    |..| | |..|   | | . |  | .|.. . | .   ... | | .|  
.ldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl

0051082 (Phosphotyrosine protein) phosphatases II 1093-1308 1.3e-26 88.4 In-house 4-149 (151) alignment
Range on Protein: 1093-1308
Range on HMM: 4-149/151.0
GYINASRVKvPVagellhYIAAQGPMEntvqDWWRMVWESGTQVIAMLTKLKEDGkeKCFKYWPDCTspkkntaefgpfrviaqfsndsgcyitsgltlr
.|||.|.|  .       ... .||..    | .....| | ..| .|....| |  .| .|.|.                                   
dyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

hvpsgeqRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSvcrhansmneveV-GPPPIVHCSAGVGRTGVLLLVDIMISSlehneeINIPKMMGILRQQR
       ..|.|... |||..|.|.  . .|.|||....              . | .||||||.||||.| ....|.        ... . .  .|..|
.......ievlhipildwpdpglplsfdavleflellld............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

MLMVQTVGQYTFVYKAL
. .||.  |. |...||
pgvvqpnqqflfqlfal

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1060-1310 1.7e-25 84.6 In-house 30-268 (285) alignment
Range on Protein: 1060-1310
Range on HMM: 30-268/285.0
SKLPENVSRNRFKDVLPYEDCRVELSSshHNsGGYINASRVKVPVAgELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCT
.    |   ||. ||   |. || |    |.   || || ...|   .   ||..|||. .|. |.|.|...     . ||  | | | |||  |.|.  
tayeanpdlnryadvrcieetrvvlkn..hd.rdyihaswmrmpgk.dqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

SpkkNTAEFGPFRVIAQFSNDS--GCYITSGLTLRHV--PSGEQRTVWHLQYNDWPNQGCPDDVHGFLsflEEFQSVcRHansMNEVEVgpPPIVHCSAG
    .  .|| . .     ..      |   ||.      | |   . |.|   ||.| .|.| . ..   | .. | ..   .|  |   |  ||||||
g...evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmi...elykwv.kk...vnpkek..picvhcsag

VGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
||||  .. .|     .  | .|..  ..  .|  |.  ||.  |. |.|  |..
vgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme

0044763 (Phosphotyrosine protein) phosphatases II 1077-1309 1.7e-24 81.9 In-house 2-168 (178) alignment
Range on Protein: 1077-1309
Range on HMM: 2-168/178.0
YEDCRVELSSSHH-NSGGYINASRVKvpvAGellHYIAAQGPmentvQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkntaefgpfrvia
....|| ||.  . ... |||||..     |    |.....|     .|......| | ..| .||. .| |..||..|||. ..               
ldrtrvllsnleglersdyinaseil...pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

qfsndsgcyitsgltlrhvpsgeqrtvWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANsmnevevgPPPIVHCSAGVGRTGVLLLVDIMISSlehn
                           .. ..  .|  |.||    || |.|  ...    .         | .|||||||||.|.| . ..|..     
...........................iqylhipipDhgvpdllehflefvefieealdekg........gpvlVHCsaGvgRsgtlvaaylmkkl....

eEINIPKMMGILRQQRMlMVQTVGQYTFVYKALI
  ..... .  .|..|. .|.. ||. ..|.   
.glsleeaielvrerRp.ivpnpgqlrqLyefel

subfamily_egg_pd Subfamily egg 1064-1309 3.3e-24 80.1 In-house 39-267 (307) alignment
Range on Protein: 1064-1309
Range on HMM: 39-267/307.0
ENVSRNRFKDVLPYEDCRVELSSSH-HNSGGYINASRVKVpvAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDgkEKCFKYWPDCTSPK
.|  . | | |   . .||.|   .   .. .| | |||      | ..| || |. |||.|.||||..   | | |||  ||   |.|  ||| . |  
nnlekarskrvhckdssrvklelrrGqylddfihanrvkG..kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

KNTAeFGPFRVIAqFSNDSGCYI---TSGLTLrHVPSGEQRTVWHLQYnDWPNQGcpdDVHGFLSFLeefqsvcRHANSMNEvevgpPPIVHCSAGVGRT
  |   | .|. . .  ||        . | |   .  |.| . | |. |. | .   ||.  |  |       |..  . .     | .|..  || ..
lvtv.pGslrien.lkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnss...dvysplrvl.......rklrnlsk.....pvvvqdilGvska

GVLLLVDIMISSLEHN--EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..|. ..| . ||         . . .  ||..| | |..| .| |||. ..
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_eak_pd Subfamily eak 1062-1313 7.8e-24 78.7 In-house 49-306 (332) alignment
Range on Protein: 1062-1313
Range on HMM: 49-306/332.0
LPENVSRNrFKDVLPYEDCRVELSSSHHNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTsp
  |.| ||   ...||.   |.|.||  |  |||||| .. .  |.  .|| .  . |. |  .|.|| |  .  | .| .  | . ||  ||.|| |  
rleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt..

kKNTAEFGPFRVIAQFSNDSGCYITSGLTLRHvpSGEQRTVWHLQYNDWPNQGCPDdVHGFLSFLEEFQSVCR------HAN----SMNEVEVGPP---P
 ..  .|| . |  .     . . |  | |.     |   | | ..  | .   |  .. ||.. .  . |        ...     ..     ||   |
.reelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk.yedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

IVHCSAGVGRTGVLLLVDIMISSLEHN--EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
|. .. |  |.||....|..|  .. .  .   . ...   ...|.  | .  |..|.|..... |.
iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1064-1158 3.6e-23 76.8 In-house 46-153 (350) alignment
Range on Protein: 1064-1158
Range on HMM: 46-153/350.0
ENVSRNRFKDVLPYEDCRVELSS--------SH-HNSGGYINASRVKVPVAGEL----LHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEK
|  ..||.|..||||  ||.|           | ...  ||||. .|... .       .|||.|.|. .||.|..... . . .|| .||.. | . ||
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CFKYWPDC
| .||.. 
cyrYWqeg

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1099-1303 8.7e-23 75.5 In-house 80-272 (301) alignment
Range on Protein: 1099-1303
Range on HMM: 80-272/301.0
RVKVPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRHVPSG-
   .|  |.  ..||.|||..|| .|.| |.     . |.||..  |. .||| .| |  .|   .. . | |..  . ..      .|  ||. . |  
anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis...ekldigrfkikiknkelilnkkiskrtlevedstg

--EQRTVWHLQYNDWPNQGCPDdvhgflSFLEEFQSVCRHANSMNevevgpPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMV
  . ||| | ||..|...| |       |  | |. .    .| .      | .||||||.||.  ..  ... . .| . .|.. . .  ||..|   |
kfatrtvthyqysewtdrgvPk......shaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv

QTVGQYTF
||. |  .
qtnsqlyw

0048076 (Phosphotyrosine protein) phosphatases II 1166-1309 8.9e-23 76.0 In-house 11-140 (145) alignment
Range on Protein: 1166-1309
Range on HMM: 11-140/145.0
AEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHansmnevevGPPPIVHCSAGVGRTGVLLLV
  .|.. .  .. .     ||  |.| . .... |......| .||  |.||.   .|.|||  ... ..         | | .|||||||||||.| . 
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.........ggpvlVHCsaGvgRtgtlvaa

DIMISslehnEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
..|..     . ..... .  .|.||. .|...||. |.|... 
ylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1110-1306 3.4e-22 73.6 In-house 6-198 (199) alignment
Range on Protein: 1110-1306
Range on HMM: 6-198/199.0
HYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQRTVWHLQY
.|||.| |. .|. |.|.||||.|.  | |.   . . .     ||| . |    |...| . | ..       |  . | |          | . | |.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes...gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

NDWPNQGCPDdVHGFLSFLeefqSVCRHANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE--INIPKMMGILRQQRMLMVQTVGQYTFVY
  | ..  |. |  |. |.       |      | |   | ||||| | | |||.. .|| . | |      ... ..   ||| |  .. .. .| |.|
tswkekttpn.valfvgfv....vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

K
.
q

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1110-1306 3.4e-22 73.6 In-house 5-197 (198) alignment
Range on Protein: 1110-1306
Range on HMM: 5-197/198.0
HYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSpkkNTAEFGPFRVIAQFSNDSGCYITSGLTLRH--VPSGEQRTVWHLQY
.|||.| |. .|. |.|.||||.|.  | |.   . . .     ||| . |    |...| . | ..       |  . | |          | . | |.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes...gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

NDWPNQGCPDdVHGFLSFLeefqSVCRHANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEE--INIPKMMGILRQQRMLMVQTVGQYTFVY
  | ..  |. |  |. |.       |      | |   | ||||| | | |||.. .|| . | |      ... ..   ||| |  .. .. .| |.|
tswkekttpn.valfvgfv....vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

K
.
q

FERM_M FERM central domain 108-222 2.8e-20 62.9 Pfam-A 4-126 (126) alignment
Range on Protein: 108-222
Range on HMM: 4-126/126.0
TLRHEMTRYMYFLQLKSDFIEGILPCNEEQAVTLASFALQAEIGNSD-PAKHTVEF-YQNE-YV----LLP-KNMTTENVSLSELLLKVMNAHQAKVGMS
 ...|........|.|.|..|. |.|.||.|. ||. .||.|.|.|. . |..     ..| .     ||| .    .. . ..|  ....||.   |.|
pkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknvagls

TCQSELGYIEQAAKLQGYGQESF
  . .| |.. | .|..|| . |
laeaklkylqaaqslpdyGvslF

FERM_N FERM N-terminal domain 25-102 1.5e-18 56.8 Pfam-A 1-79 (80) alignment
Range on Protein: 25-102
Range on HMM: 1-79/80.0
IQLLDSAVLEITLTPESLGQDCLDTIAQKLQLEENIYFGLQY-SNKNYKLRWVDLEKPLKKQLDKNAHDSMLRLGVMLY
..|||..|.|.|. ... |...|.|....|.|.|. ||||..   |. . .|.|..| |..|....  . .| | |  |
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfy

0048179 (Phosphotyrosine protein) phosphatases II 1188-1306 5.6e-18 60.5 In-house 35-139 (144) alignment
Range on Protein: 1188-1306
Range on HMM: 35-139/144.0
GLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVcrhansmneVEVGPPPIVHCSAGVGRTGVLLLVDIMIsslehNEEINIPKMMGIL
 ||  . |  . |....... .||. |.||. . .|.||| ....         .| | | .|||||||||||.| . ..|.      . ... . .  .
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieea.........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalv

RQQRMLMVQTVGQYTFVYK
|..|. .|.. ||. |...
rsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1029-1313 2.2e-17 57.5 In-house 16-286 (302) alignment
Range on Protein: 1029-1313
Range on HMM: 16-286/302.0
RKILEKQLREGQVFTEYEQITKK-REGAVCYTSKlpENVSRNRFKDVLPYEDCRVELSsshHNSGGYINASRVKVPVAGelLHYIAAQGPMENTV---QD
 | | |.| ...| .|...| .   .   | . |  .|...|. .||  ... .| |.   ..   |.|||.|.||  .     | || |  ...   ..
akklvksldtaevkkefkkidtmkvdlekCkafk..knlkknqsedvpildsnlvkle...aepdsyvnaskvevPelt..rsiilaQlpkvdsedsvee

WWRMVWESGTQVIAMLTKLKEDGKeKCFKYWPDCTspkKNTAEFGPFRVIAQFSNDSgCYITSGLTLRHVPSGEQRTVWHL--QYNDWPNQGCPDDVHgf
.||||..   . . .| . .|  |    ...|  .    .  |.| ..|  .  . .    .. ...  .| |   .|       . |...  |. .   
FWrmvfqekivsvvilvgeeelkk.tlselfpkks...gdykeygkmfvNnrkVeka.eeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya..

lSFLEEFQSVcrhanSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
 .  .. ..|      ......  . ..    |.|| |..| . . ...|....| ||  ..  .|.||  .|... ||...| ||.  .|
.eliktaakv.....fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1201-1309 2.2e-16 54.5 In-house 216-341 (350) alignment
Range on Protein: 1201-1309
Range on HMM: 216-341/350.0
TVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRH--ANSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISS-------LEHNEEIN--------IPKM
 |..||.. |.. .   . . .|. ||  . .     |.|  . . ..| .|||||||||||.|. .| ..|         .. ....        |  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

MGILRQQRMLMVQTVGQYTFVYKALI
. .||.||. |||.. |. |.|.|| 
vnelrkqrismvqnldqfifiYeall

subfamily_CG42327_pd Subfamily CG42327 1247-1309 7.1e-16 52.7 In-house 249-312 (319) alignment
Range on Protein: 1247-1309
Range on HMM: 249-312/319.0
PPIVHCSAGVGRTGVLLLVDIMISSLEHN-EEINIPKMMGILRQQRMLMVQTVGQYTFVYKALI
| .|||| ||||||...  || | |||.. . ..||...  .|..|   |.|. || |.|| | 
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1045-1310 1e-15 52.2 In-house 28-277 (303) alignment
Range on Protein: 1045-1310
Range on HMM: 28-277/303.0
YEQITKKREGAVCyTSKLPENVSRNRFKDVLPYEDCRVELSSSHhnsggYINASRVKVPVAGellHYIAAQGPMENTVQDWWRMVWESGTQVIAML-TK-
.|...      |.   .. .|. .||| ||.  .  .|.|| |      || || ...       . | .| |.  |  |.|.|. |   ... .| |  
fekvvsylppsvs.knqfvknmdknrfvdvicldhskvklsdss.....yihasyleldssk...kailtqlplshtaadfwqmiieqkvkcvlllltds

-LKEDGKEKCFKYWPDCTSPKKNTAEFGPFRviaqfsndsGCYITSGLTLR--HVPSGEQRTVWHL-QYNDWPNQGCPDD-VHGFLSFLEEFQSVCRHAN
  .. | .  |    |    .. .   | |.            .. | .|.   |  |. ..  |. .|..|| .  | |    |.  . . ||| |.  
eydklggdsvfprnqdflkfeersirvgefk.........rvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys

SmnevevGPPPIVHCSAGVGRTGVLLLVDIMISSLEH-NEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQ
       . |..    .|.||.| . | .    ||   .  ... | .  .|. |.  || . |...||  | .
d......stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1197-1312 2.2e-15 51.0 In-house 86-194 (440) alignment
Range on Protein: 1197-1312
Range on HMM: 86-194/440.0
GEQRTVWHLQYNDWPNQGCPDDVHGFLSFLeefQSVcrhaNSMNEVEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQ
 | ||. . .|. ||..| |  .   | ..   | |    |  .|     | .||||||.|||||.. || ..   .....|.|  ..  .|..|  |||
iesrtlkqyhyqgwpdkgvpkfagpvlkmi...qdv....nesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvq

TVGQYTFVYKALIQSL
|  ||.||..|....|
tpeqyafvheavlegl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1121-1305 3.4e-14 47.5 In-house 40-214 (255) alignment
Range on Protein: 1121-1305
Range on HMM: 40-214/255.0
TVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKNTAEfgpFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVH
||. .....  ..|.|..||. ..|.|.||| .|.|     |.  |.     |..  |       |  .|.      . .|| | .|. |...  |.. .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad...vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

GFLSFLEefqsVCRHANSMnevevgpppIVHCSAGVGRTGVLLLVDI----MISSLEHNE--EINIPKMMGILRQQRMLMVQTVGQYTFVY
  |  |     | |.. |.         .||||.|.||.  . |...    || ||.  |  |..  ...  ||..|   ..|  | .|  
eilnilk....vvrdsksv.........vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1065-1158 1.5e-13 44.8 In-house 48-156 (349) alignment
Range on Protein: 1065-1158
Range on HMM: 48-156/349.0
NVSRNRFKDVLPYEDCRVELSSSHHNS---------------GGYINASRVKVPVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKE
  ..||.||.||||  || |  | ..|                 ||||  .|..      .||| | |.  ||.|.....   | ...  |.. || . |
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCFKYWPDC
|| .|| . 
kcdiywqel

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1116-1308 2e-13 44.5 In-house 98-284 (302) alignment
Range on Protein: 1116-1308
Range on HMM: 98-284/302.0
GPMENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTspkKNTAEFGPFRV--------IAQFSNDSGCYI-TSGLTLRHVPSGEQRTVWHLQ
 |  .|.. .| .. .  . ... |....||...|| .|. |     ... .|| . |        ...|..  .  . |  ..  .. .  ..||  |.
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv...ggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

YNDWPNQGCPDDVHGFLSFLeefqsvcRHANSMNEvEVgpppIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYK
.  ||. | |.. .  |  |       .. .|  . .|    .||||||||||| |. .   |    ...  .. ...  .|| |   ||.  | ...  
fsawpdhGapkeaytaldil.......kfcesykk.nv....lvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll

AL
 .
cv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1201-1310 1.4e-12 41.6 In-house 219-342 (349) alignment
Range on Protein: 1201-1310
Range on HMM: 219-342/349.0
TVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANSMNEVE--VGPPPIVHCSAGVGRTGVLLLVDIMIS--SL--EHNEEINIPKM--------MGI
 .. ||. .|.. .   .   .|  ||  . .    .. . ..    .. .|||||| ||||||  .|...|  .   ..   |... .        . .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRQQRMLMVQTVGQYTFVYKALIQ
||.||. ||| . |. ..|.||..
lrkqrismvqnlaqfiaiyealLk

FERM_C FERM C-terminal PH-like domain 226-306 1.1e-11 35.1 Pfam-A 1-84 (90) alignment
Range on Protein: 226-306
Range on HMM: 1-84/90.0
DDSGNELFISASFSGLSVKHLNRQE-TVHFEWHEVVSMGHNRRAFGVGTS--RSHDVLQFQMEDAETAKYVCRICRLQQQFHKY
. .|..|... . .|| . . |..    .|.|.|.  . .... | . ..   . |||.|........|.....|  ...... 
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1091-1308 1.5e-11 39.0 In-house 45-255 (290) alignment
Range on Protein: 1091-1308
Range on HMM: 45-255/290.0
SGGYINASRVKVPVAgelLHYIAAQGPME-------NTVQDWWRMVWESGTQVIAMLTKLKEDGKE----KCFKYWPDCTSpkkNTAEFGPFRVIAQFSN
. .|| |.||..|     |. |. | | |        |....| |. .   . . || . .|  ..     | || |.      .   |. . |  .   
nddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg...eelkfkgltvkCkske

DSGCYITSGLTLRHvPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQsvCRHAnsmnevevgpPPIVHCSAGVGRTGVLLLVDIMISSLE-HNEEI
     .|  |....   .|. || | ....| .   ..|   .|| ..  .  ....          | ||||  |. |  .|  ...    .   ....
keddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvk..askt..........pvivHcvdGiSrsAalaaiilgyQkiaetsgsv

NIPKMMGILRQQRMLMVQTVGQYTFVYKAL
.. ...  ||.|| |....  ...||  ..
kledvlkalrkqralaitsalelafvdagi

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1050-1158 1.6e-10 35.1 In-house 81-181 (244) alignment
Range on Protein: 1050-1158
Range on HMM: 81-181/244.0
KKREGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHnSGGYINASRVKvpVAGELLHYIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEDGke
 . . .|   .  |.|  .||    ||..  || || .   .  ||||| |     |    || .| |. .|  |.|.|. |   .|. .|  ..|.   
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsm.gntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed..

kcfKYWPDC
   .|||| 
...eywpds

subfamily_hpo-7_pd Subfamily hpo-7 1120-1305 2.1e-10 35.0 In-house 45-220 (263) alignment
Range on Protein: 1120-1305
Range on HMM: 45-220/263.0
NTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKNtaeFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDV
.|..  ....  ..|.|..||.  .|.|.||| .|.|     |.    .    | .  . .     |  |.       . .|| | .|. |...  | . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk...lanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

HGFLSFLeefqsvcRHANSMNEVEvgpppiVHCSAGVGRTGVLLLVD----IMISSLEHNEE--INIPKMMGILRQQRMLMVQTVGQYTFVY
.  |  |       . |    ...      ||||.|.||.    ...     || ||.  .   ..  ...  ||..|   ..|  |  |  
reilnil.......kvarnskslv......vhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1056-1150 3.8e-09 30.5 In-house 28-127 (347) alignment
Range on Protein: 1056-1150
Range on HMM: 28-127/347.0
VCYTSKLPENVSRNRFKDVLPYEDCRVELSSSH------HNSGGYINASRVKVPVAGEllHYIAAQGPMENTVQDWWRMVWE-SGTQVIAMLTKLKEDGK
 . ...   ..|.|| |||   .. || ||  .       .. .||||| .|   | .  .|| .| |. .||.|.|.||     |||....   |..  
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnask..eyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai

EK
|.
ee

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1249-1313 5.8e-08 27.0 In-house 2-66 (69) alignment
Range on Protein: 1249-1313
Range on HMM: 2-66/69.0
IVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLK
.||||.| |||| .. . . .. .  .  ..|   .  .|. | .||    .| |.. ||...||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1249-1314 7.6e-08 26.6 In-house 1-66 (69) alignment
Range on Protein: 1249-1314
Range on HMM: 1-66/69.0
IVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQTVGQYTFVYKALIQSLKN
.||||.| |||| .. . . .. .  .  ..|   .  .|. | .||    .| |.. ||...|| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1111-1177 3.9e-07 23.7 In-house 238-297 (440) alignment
Range on Protein: 1111-1177
Range on HMM: 238-297/440.0
YIAAQGPMENTVQDWWRMVWESGTQVIAMLTKLKEdgkEKCFKYWPDCTspkkNTAEFGPFRVIAQF
.||.| |.. || |.||.| .     | || .|..     |  |||  |     .  |||| |  . 
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt....rsvtfgpftvghkg