Gene PTPN23-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP059_AA protein Get Run
SpurP059_AA_231-513 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN23_pd Subfamily PTPN23 233-520 3.1e-143 470.8 In-house 2-288 (288) alignment 
Range on Protein: 233-520
Range on HMM: 2-288/288.0
YVEGLNRKMLSGPTVIERLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWL
.|| |.||||.| |.... .|||...||.|.|..|||||..|| |||. ||.|||||||.|||..||||||||.||..|..|.|||||||||..||||||
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl

MVYEQQASIIVMLLSKPATGKGSTNfvSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDE
|||||..|.|||||||...|| ...  .|||||||...||||.||.|.|.|.|..||||...|..|.........|||.|.|||.|||.||..||||.||
mvyeqkssviVmllskeelgkpkvd..rYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VQS-YHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAKRG
|.| |...|||...|.|||||||..|||||.|||.|.||...|.|..||.|||..|| |||.|..|||||||||.|.|..||..| |||
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG
0050432 (Phosphotyrosine protein) phosphatases II 239-514 1.4e-78 259.7 In-house 37-301 (308) alignment 
Range on Protein: 239-514
Range on HMM: 37-301/308.0
RkmLSGPTVIERLWKELTNYQDreTRQFSIAIARCYSVKNRHPDIMPYDHNRVCLrGTRDDYINASFIKDVV-PTSPCFIATQAPLQPSLNDFWLMVYEQ
.  . ... .|. ..||.....   ...|.|   .   |||..||.||||.||.| .  .||||||...  .   .  |||||.||. ...||| ||.||
k..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

QASIIVMLLSKPAtgKGSTNFVSYWPEDKG-AAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSY
. ..|||| .     .|  ..  |||.. |   ...|...| | |  . |... | ..||.| . ..||.||...|.||..|||.||  ||.|...|...
nvrvIvmLtklve..ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

HsqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
.      . |||||||||. |||.|...... . .... |  |....||||| ||  |.  .||..| |.|.|.|.. 
l.....pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 233-512 8.6e-76 250.4 In-house 10-286 (288) alignment 
Range on Protein: 233-512
Range on HMM: 10-286/288.0
YVEGLNRKMLSGPTVIERLWKELTNYQDRetRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG----TRDDYINASFIkDVVPTSPCFIATQAPLQPSLN
... .......|.| ... ..||....    ...|.|.  ..  |||..||.||||.||.|.       .||||||.| |. ...  |||||.||. ...
llklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgPlpntve

DFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEdkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHL----PTRQMRTITHLQFTAWPEFGVPSSPG
||| ||.||. ..|||| .     .| ...  |||.  |  ...|||.| | |  . |. . | ...|.|    .. . ||.||...|.||..|||.|| 
dFWrmvweqnvrvIvmltklve..lgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

VLLQFIDEVQSYHSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
 ||.|. .|.....   ... |.|||||||..|||.|...... . .... |  |....||.|| ||  |.   ||..| |.|.| |.
llldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 246-514 1.1e-74 246.8 In-house 13-279 (297) alignment 
Range on Protein: 246-514
Range on HMM: 13-279/297.0
TVIERLWKELTNYQDreTRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
. ... ..||....      .|.|.  ..  |||..||.||||.||.| .  .||||||.. |.   .  |||||.||. ...||| ||.||. ..||||
alllkefeellplll..lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

LSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRT--TDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKT
 .     .|  .. .|||...|  ...||..| |.|  .   |. . | ...|.. . . ||.||...| ||..|||.||  ||.||..|......    
telve..lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.ps

QIPIVVHCSAGIDRTGVFCLVYTAAREINE--GHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
. |..||||||. |.|.|...... . ...   .|  ||...||||| || ...   ||..| |.|.|.. ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0046845 (Phosphotyrosine protein) phosphatases II 250-514 1.3e-74 246.4 In-house 4-276 (284) alignment 
Range on Protein: 250-514
Range on HMM: 4-276/284.0
RLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG-----TRDDYINASFIKDVV----PTSPCFIATQAPLQPSLNDFWLMVYEQQAS
. ..||....   . ..|.|.. ..  |||..||.||||.||.|.        .||||||...        ... |||||.||. ...||| ||.||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

IIVMLLSKPAtgKGSTNFVSYWPEDkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLP-TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQ
.|||| .     .| . .  |||.. |  ...||..| | |. . |... | . ||.|  | . ||.||...|.||..|||.||  ||.|...|......
vIVmltelve..ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

qRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHG--IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
 .... |||||||||. |||.|...... . .....     |....||.|| ||  |.   ||..| |.|.| |...
.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 243-512 2.3e-74 245.6 In-house 9-272 (273) alignment 
Range on Protein: 243-512
Range on HMM: 9-272/273.0
SGPTVIERLWKELTNYQDreTRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASII
.|.|.... ...|.....     .|.|.  ..  |||..||.||||.||.| .  .||||||.. |. .... |||||.||. ...||| ||.||....|
lgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLLSKPAtgKGSTNFVSYWPEDKGA-AQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQR
||| .     .|  ..  |||.. |   ...|...| | |  | |... | . ||.| | . ||.||...| ||..|||.|.  ||.||..|...... .
VmLtelve..lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

KTqIPIVVHCSAGIDRTGVFCLVYTAAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
.   |.|||||||. |||.|...... . .... |  |....||.|| ||  |.   ||..| |.|.| |.
sn.gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 251-511 8.8e-72 237.5 In-house 25-280 (564) alignment 
Range on Protein: 251-511
Range on HMM: 25-280/564.0
LWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRD----DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
. .|  . . ... ... | . .   |||  .|..|||.||.|. ..     ||||||||.    ..  .||||.||.....||| ||.||. |.|||| 
feeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmlt

SkpATGKGSTNFVSYWPEDkGaAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsQqrKTQIP
.     || . . .||||. |  ...|.. |.|... .  . . | . |..  ....|.... .||.||. ||| |.  ||..|..|.... .  ... |
k..leEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e..pdagP

IVVHCSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
||||||||. |||.|. .    . |.|  .  || |.||.|| ||  |. ..||  | ..||| .
ivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailea
0045450 (Phosphotyrosine protein) phosphatases II 232-511 1.6e-71 236.9 In-house 13-303 (307) alignment 
Range on Protein: 232-511
Range on HMM: 13-303/307.0
MYVEGLNRKMLSGPTVIERLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG-----TRDDYINASFIKDVV-------PTSPCFIAT
...  .....|...| ... ...| .....    .|||   .   |||..||.||||.||.|         .||||||.... .         .  ||||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QAPLQPSLNDFWLMVYEQQASIIVMLLSKPatGKGSTNFVSYWPEDkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHL-PTRQMRTITHLQFTAWPEFG
|.||. ...||| |..||. ..|||| .     .|.   . |||.. |  . .|.. | | |. . |. . | ...|.| .| . ||.||...|.||..|
qgPlpetvedFwrmlweqgvtvivmltelv..elgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg

VPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGI--ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
||.|.  ||.||.||......  . . |..||||||..|||.|.. |.. | ..... .   |....||.|| || ...   ||..| |.|.| .
vppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 241-513 2.4e-71 236.0 In-house 13-277 (317) alignment 
Range on Protein: 241-513
Range on HMM: 13-277/317.0
MLSGPTVIERLWKELTNYQDRetrQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYE
..|. |.... ...| ...      .|.|.  .   |||.|||.||||.||.|  .     .||||||.. |.   .. |||||.||. ...||| ||.|
lksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvwe

QQASIIVMLLSKPAtgKGSTNFVSYWPEdkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSY
|. ..|||| .     .|  ..  |||.  |  ...||..| |.|  . .. . | .....| . . ||.||...|.||..|||.||  ||.|...|...
qgvtvivmLtelee..lgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

HSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
 .   . . |..||||||..|||.|...|.. . .....   |....||.|| ||. ..   ||..| |||.|.| .
le...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk
0039614 (Phosphotyrosine protein) phosphatases II 240-513 1.2e-69 230.4 In-house 26-290 (297) alignment 
Range on Protein: 240-513
Range on HMM: 26-290/297.0
KMLSGPTVIERLWKELTNYQDrEtrqFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR-----DDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMV
. ....|.... ..|| .... .   .|||   .   |||..||.||||.||.| . .     .||||||...    ... |||||.||. ...||| ||
ekansktllllefeellslkp.d...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

YEQQASIIVMLLSKPATGKgstNFVSYWPEDKGaaqKFGDISVSLQSKRTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQ
.||. ..|||| .    |.    ...||||. |   ..||..| | .  . |. . | ...|.  . . ||.||.|.| ||..|||.|. .||.|...|.
weqgvtvivmLtklvelgr...kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

SYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
.....  . . |..||||||..|||.|.. |.. . .... |  |....||.|| ||....   .|..| |||.| . .
ealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 243-511 4.6e-68 225.0 In-house 14-276 (278) alignment 
Range on Protein: 243-511
Range on HMM: 14-276/278.0
SGPTVIERLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQ
 ....  .|..|  ....  .  .|||.  .   |||..||.||||.||.|  .     .||||||.. |. . .. |||||.||. ...||| ||.|..
lllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpetvedFwrmvwelg

ASIIVMLLSKPAtgKGSTNFVSYWPedkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHS
 ..|||| .     .|..... |||   |  ...||..| |..  . |. . | ...|.| . . ||.||.....||..|||.|.  ||.|. .|... .
vttivmLtelve..lgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
   . . |..||||||..|||.|...|.. . .. ..   |....||.|| || ...   .|..| |.|.|.|
...dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley
DSPc_SM00195 254-512 3.7e-67 221.8 In-house 5-262 (263) alignment 
Range on Protein: 254-512
Range on HMM: 5-262/263.0
ELTNYQDR-ETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
| .....  ...... |.    . |||. .|.||||.|| |  .     .|||||..||     .  .||||.||.  ..||| ||.|.. .||||| . 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmltee

PATgkGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTD-YHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPI
     |...  .||||..|  ..||.||| |... ...   . | ..||.  ... |..|..|...||. |||.|.  .|... .|.. .|..   . ||
een..gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

VVHCSAGIDRTGVFCLVYTAAREINEGHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
|||||||..|||.|... .. ....|..   || ..||.|| ||  |....||..| |.||| |.
vVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 254-512 3.7e-67 221.8 In-house 5-262 (263) alignment 
Range on Protein: 254-512
Range on HMM: 5-262/263.0
ELTNYQDR-ETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
| .....  ...... |.    . |||. .|.||||.|| |  .     .|||||..||     .  .||||.||.  ..||| ||.|.. .||||| . 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmltee

PATgkGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTD-YHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPI
     |...  .||||..|  ..||.||| |... ...   . | ..||.  ... |..|..|...||. |||.|.  .|... .|.. .|..   . ||
een..gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

VVHCSAGIDRTGVFCLVYTAAREINEGHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
|||||||..|||.|... .. ....|..   || ..||.|| ||  |....||..| |.||| |.
vVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 276-509 3.3e-66 218.4 Pfam-A 3-234 (235) alignment 
Range on Protein: 276-509
Range on HMM: 3-234/235.0
VKNRHPDIMPYDHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFG
 |||..||.|||..|| |  .... |||||...|    ..  |||||.||. ...||| ||.... ..|||| |    |.  ...  ||||...  ...|
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr..ekcaqYwpeeeeesltyg

DISVSLQ--SKRTTDYHVERIIHLTHLPTRQ-MRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAARE
||.| |.  .|. ..  . | ..|..  ...  |....|..|.||. |||.||  ||..|..|....   .... |.|||||||. |||.|... .. ..
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleq

INEGHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
.....   |. |.||.|| ||. |... ||..| |.|||
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 276-509 3.3e-66 218.4 In-house 3-234 (235) alignment 
Range on Protein: 276-509
Range on HMM: 3-234/235.0
VKNRHPDIMPYDHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFG
 |||..||.|||..|| |  .... |||||...|    ..  |||||.||. ...||| ||.... ..|||| |    |.  ...  ||||...  ...|
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr..ekcaqYwpeeeeesltyg

DISVSLQ--SKRTTDYHVERIIHLTHLPTRQ-MRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAARE
||.| |.  .|. ..  . | ..|..  ...  |....|..|.||. |||.||  ||..|..|....   .... |.|||||||. |||.|... .. ..
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleq

INEGHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
.....   |. |.||.|| ||. |... ||..| |.|||
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 264-513 8.7e-65 214.2 In-house 23-273 (278) alignment 
Range on Protein: 264-513
Range on HMM: 23-273/278.0
RQFSIAIARCYSVKNRHPDIMPYDHNRVClrgtrdDYINASFIKDVvptSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWP
 ... |. ..   ||| .||.||||.||.      ||||||.|.     .. |||||.||.  ..||| |..|.. ..|||| .   . .|   .. |||
seitpalylgnldknRykdilpydhsrVk......dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmlte..lvelgrekcaqywp

EdkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHL----PTRQMRTITHLQFTAWPEFGVPSSP--GVLLQFIDEVQSYHS----------QQRKTQIPI
|  |  . .||..| |.|  ..|. . | ...|.|    .. . |..|||... ||..||||.|    .|...........          ..   . |.
e..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSAGIDRTGVFCLVYTAAREInegHGIADIPQVVKKLRLQRRW-MISEKEQLKFSYDAILCYAR
.||||||..|||.....|.  . .   .|  |....||.|| ||.  ..  .||..| |...| . .
lVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 267-511 2.2e-63 209.5 In-house 4-245 (249) alignment 
Range on Protein: 267-511
Range on HMM: 4-245/249.0
SIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYW
|.|.  .   |||.|||.||||.||.|  ..    .||||||.| |.   .. |||||.||. ...||| |..|.. ..|||| |      |  ..  ||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel..grekcaqyw

PEdkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFC
|.  |  ...||..| | |  . |. . | ..||.| . . ||..|.|.| ||..|||.|.  ||.||..|......  ... |..||||||..|||.|.
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

LVYTAAREINEGHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
. |.. . ... .|  |....||.|| ||....   ||..| |.|.| .
aaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 227-511 9.4e-63 207.2 In-house 4-279 (318) alignment 
Range on Protein: 227-511
Range on HMM: 4-279/318.0
VERLDMYVEGLNRkmlSGPTVIERLWKELTNYQDRETRQFSiaIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVvPTSPCFIATQAP
|| |.. |. |..   || ..... ...|.  ..  |.  |  .  .   |||. .|..||| || |. .      |||||..|      .  .||.|||
vedleshvrrlre...sGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy.rrkkayiaaqaP

LQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKgaAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSS
|   ..||| ||.||....||||  .   ||  .    |||...  ....|.. | |... .....| | ...|.  . . |..   ..|.||. |||.|
lpetieDfWrmvWeqnsavivmltqeeergk..akvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

PGVLLQFIDEVQSYhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
.. ||... .|...  ||.... |||||||||. |||||. | .  . |..  .. |. |.||.|| ||  |.  ..| .| ||..| .
gaslldlvrqvska..qqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
0042113 (Phosphotyrosine protein) phosphatases II 268-511 3.9e-62 205.2 In-house 3-242 (245) alignment 
Range on Protein: 268-511
Range on HMM: 3-242/245.0
IAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWP
.|.  .   ||| .||.||||.||.|  .     .||||||.. |.   .| |||||.||. ...||| |..|.. ..|||| .     .|  ..  |||
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee..lgrvkcaqywp

EdkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqrKTQIPIVVHCSAGIDRTGVFCL
.  |  ...||..| | |  . |. . |....|.|.. . |...|.... ||..|||...  ||.|...|... ..  . . |..||||||..|||.|..
l..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia

VYTAAREINEGHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
.|.... ... .|  .....||.|| ||....   .|..| |.|.| .
aylmleqlekelg.vsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN3_pd Subfamily PTPN3 258-510 1.5e-61 202.8 In-house 25-273 (280) alignment 
Range on Protein: 258-510
Range on HMM: 25-273/280.0
YQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKDVVPTSP---CFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKG
|. .. .. |.|      .|||. ||.|||. || |. .. |||||....  .|..     .|||| ||. . .||| ||.||..|.|||| .   . .|
yrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl..verG

STNFVSYWPEdKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAG
 .    |||| ..  ...|..|| ......|  .| | . |..  |.. |.|..||..|||. |||...  .|.|...|....   . .. |.|||||||
rvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhCsaG

IDRTGVFCLVYTAAREInEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
|.||||. |. ||   | | .    ....|...| ||  ..  ..| ||  .||| 
igrtGvlilletalali.eaaepvypldivrtmrdqramlvqtasqykfvCeailk
0037934 (Phosphotyrosine protein) phosphatases II 267-511 5.8e-61 201.4 In-house 3-241 (243) alignment 
Range on Protein: 267-511
Range on HMM: 3-241/243.0
SIAIARCYSVKNRHPDIMPYDHNRVCLRGtrDDYINASFIKDVvptsPCFIATQAPLQPSLND----FWLMVYEQQASIIVMLLSKPATgkGSTNFVSYW
|||.  .   |||..||.||||.||.| |  .|||||..|. .    | .||||.||. ...|    || |..|.. ..|||| .      |  . . ||
siallpenlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvEl..grekcaqyw

PeDKGaaqKFGDISVSLQSKRTTDYHVERIIHLTHLP-TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQ-----QRKTQIPIVVHCSAGID
| ..     .||..| | | ...|. . | ..|..|. . . |...|.....||..|||.||  ||.|.|||... ..     ..... |..||||||..
p.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGVFCLVYTAAREIneghGiADIPQVVKKLRLQRRW-MISEKEQLKFSYDAILCY
|||.... |.  . .    |  |. ..||.|| ||   ..   .|..| |.|.|..
RtGtliaaylmllll....g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 246-511 1.1e-60 200.4 In-house 27-289 (298) alignment 
Range on Protein: 246-511
Range on HMM: 27-289/298.0
TVIERLWKELTNYQD-RETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQAS
|. .  ...|.. ..  |. . ..| ..    |||..||...|. || |.        |||||||..     .. ||||||||.....||| || |....
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedFWrmvteedig

IIVMLlsKPATGKGSTNFVSYWPEDKgaAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhSQQ
 ||||  .. . .. |..  |||...  ....|.|.|||.|| .    . | .....  ... |.. .|.|| ||. |||.    .|.....|.   |||
tiVml..tnleeldktkyhkywPdeg..ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra..sqq

RKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
.  . |..|.||||..|.| |. ...    ... . . |. |||| || .|  ..  .|| .| |.|.| .
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPRB_pd Subfamily PTPRB 264-513 5.6e-60 197.8 In-house 41-286 (293) alignment 
Range on Protein: 264-513
Range on HMM: 41-286/293.0
RQFSIAIARCYSVKNRHPDIMPYDHNRVCL----RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFV
.. ..| . . . |||. .|.||||.|| |      . .|||||..|..   .   ||||| ||  ...||| ||.|...||||||       || .   
qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltq..lvekgkvkCe

SYWPEDKGaAQKFGDISVSLQSKRTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqQRKTQIPIVVHCSAGIDRTG
 |||.|.  .. .|||.|.|....... .| | .....  ....|......||.||..|||...  ||.|. .|..... . ... |||||||||. |||
eYWPadee.pvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCsaGvGRtG

VFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
.|  . .  ..|.| . . ||  .| .|| .| ...  ..|  | ....| . |
tfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN9_pd Subfamily PTPN9 263-514 6.3e-60 197.7 In-house 31-292 (297) alignment 
Range on Protein: 263-514
Range on HMM: 31-292/297.0
TRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNF
. .|  .  |. . |||. |.. ||. || |  .      |||||.|. |      .||||| ||.   .|||.||.||.. .|||        .|    
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfv.dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr..vvergrlkc

VSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQ----------RKTQIPIV
  |||........|||.|||  . .... ...|......  |...|..|| ||..||..|||||   ||.....|... ..           . .. |||
gqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPiv

VHCSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
||||||| ||| |. .  .  ...|  | .|. ..||.|| || ..|   || .| | |.| || .
vhcsaGiGrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 226-513 6.6e-59 194.5 In-house 6-284 (319) alignment 
Range on Protein: 226-513
Range on HMM: 6-284/319.0
EVERLDMYVEGLNRkmlSGPTVIERLWKELTNYQDRetrQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRD----DYINASFIKDvVPTSPCFIATQA
||. | .... |.    .| | .|. .|.| . ..    .|. |     . |||...|..||. || |    .    ||||||||         ||||||
evqeLkerlkalas...tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqa

PLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDKgaAQKFGDISVSLQSKRTTDYHVERIIHLtHLPTRQM--RTITHLQFTAWPEFGV
||.  ..||| ||.|...||.|||     . |.  ..  |||| .   ...| . | |.... ..  . | ..| .  . ..  |...| |.|.||. .|
PlentiedfWrmvWeeessivvmltkl..veklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdv

PSSPGVLLQFIDEVQsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
| .   ||... ...  .|...... |||||||||. ||| |. .  .   ..|  |. |. ..|..||.||  |....|| || |.|.| .. 
Pekatslldllkrir..ksrektqsgPivvhCsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 250-511 3.2e-58 192.0 In-house 25-278 (288) alignment 
Range on Protein: 250-511
Range on HMM: 25-278/288.0
RLWKELTNYQDreTRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
. .. |.. .   |.. ...       |||...|.|||..|| |..    .  ||||||.|..    .  .||||.||. ..|||| .|||...| ||||
eeynsLaalek..tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenktstivml

LSkpATGKGSTNFVSYWPEDkGAAQKFGDISVSLQSKRTTDYHVERIIHLThlPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQI
 .     .| |.   |||.. .  ...|.. | |....... .|.| . |    . . ..||..|..|||. ||| |   ||.... |.  ....   . 
te..lveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tg

PIVVHCSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
||.||||||. |||.|  . ..  ...| .   |.  .|.||| ||  .. ...|  | |...|  
piivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 258-513 9.1e-58 190.6 In-house 24-277 (281) alignment 
Range on Protein: 258-513
Range on HMM: 24-277/281.0
YQDRETRQFSIAIA-RCYSVKNRHPDIMPYDHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATG
 .. .... . |       .|||. .|. ||. || .    . .  |||||.|.. .      .||||.|.  ||..|| ||.||..|.|||.  .  .|
laaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy.kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieag

KgsTNFVSYWPEDKgAAQKFGDISVSLQSKRTTDYHVERIIHLtHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqIPIVVHCS
|       |||.|. .. |.||. |. ......  ..|| ..| .  . . |....|..||||. |||...  ||.| .||........|  .|.|.|||
k..lkChrYWPddn.selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..aplvihCs

AGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
||. |||..  . ........ .  .|. .||..|| .| .|.    | .| | |.| .  
aGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN6_pd Subfamily PTPN6 252-514 1.1e-57 190.4 In-house 32-299 (306) alignment 
Range on Protein: 252-514
Range on HMM: 32-299/306.0
WKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCL--RGT-RDDYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
..|| . . ... . . .    .  |||.  |.|.||.|| |   ..  .|||||..||. |..|  ..||||  |.  ..||| ||..... .|||.  
feelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttk

KpaTGKGSTNFVSYWPEDKGAAQkFGDISVSLQSKRTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQR-KTQI
.  . .|    . |||. .   . .|.|||.  |...... . | .....    .. |.. ...|..||. |||..||..|.|...|.. ... . ... 
e..vErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PIVVHCSAGIDRTGVFCLVYTAAREINEG--HGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
|||||||||| ||| | .. .  . |..   .   || ..||..| ||  ..  ..| || | ||  | ..
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 260-511 3.5e-57 188.9 In-house 33-282 (305) alignment 
Range on Protein: 260-511
Range on HMM: 33-282/305.0
DReTRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG--TRD--DYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgs
..   .. .        |||. .|...|..|. |.   . |  ||||||...     . ..|..|.||.  ..||| ...| . | ||||      ||  
ee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggk..

TNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqIPIVVHCSAG
     |||| |.  ..||..|| |.|..|.  ..|| ....     .. ||....|.| ||. ||| ... ||..|..||  ......   |..||||||
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg..vpllVhCsag

IDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
. |||||. |  |   ...  .. |. .|.|.|| .|  |.....|  | .||.  .
vgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN1_pd Subfamily PTPN1 249-513 5.8e-57 187.6 In-house 5-272 (290) alignment 
Range on Protein: 249-513
Range on HMM: 5-272/290.0
ERLWKELTNYQDRETRQFSIAIARCYSV--KNRHPDIMPYDHNRVCLRGTRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLl
.||.||. .  ..|...|... |.  .   .||. |. |||| |. |. .  ||||||... .      .| || ||    . ||.||.||..  .||| 
krlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvml.

sKPATGKGSTNFVSYWPEDKG-AAQKFG--DISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKt
      |...  ..|||...   . ..    ..| | |. ...|.. |...|. | |.. |.|.|  .|.||.||||.||. .|.|. .|..  | ... 
.nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd.

QIPIVVHCSAGIDRTGVFCLVYTAAREINEGHG--IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
. | |.|||||| |.| |||| |   .|.. .     || .|. .|| .|  .|  ..||.||| |||  |.
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_PTPN14_pd Subfamily PTPN14 260-513 6.4e-57 187.8 In-house 35-297 (300) alignment 
Range on Protein: 260-513
Range on HMM: 35-297/300.0
DRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR---DDYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgs
 ||  ..| |       |||..|..||..||| |  |.   ..||||| || .| ..   .|..|.||.  ..||| ||.||. ..|||| ..   ||  
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk..

TNFVSYWPED--KGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRK------TQIPI
.  ..|.|..  |    .||   |. . ....|  . . ..| |||... ||. |||.| ||. |||. .   |....||||   .  .      .. |.
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VVHCSAGIDRTGVFCLVYTAAREINEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
.||||||. ||||  |.      .. .. | ||..|...|| ||  ...   | || |.... | .
lvhCsaGvGrtGvlilsdlliatlehneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 274-515 1.3e-56 186.7 In-house 28-271 (274) alignment 
Range on Protein: 274-515
Range on HMM: 28-271/274.0
YSVKNRHPDIMPYDHNRVCLRG---TR--DDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGA
 . |||. .|.| .. ||.|.    .    .|||| .||    .| ...||| ||.  ..|||.|.|......||||     . .  .  . |.|.....
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk..lkeaneqkCavyfPdaedy

--AQKFGDISVSLQSK-RTTDYHVERiIHLTHLPTrqMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVY
  ....||...  ... .. ||.|.. . | .|     |...|  .|.||.  .| ..  ||....||.. .... .   |.|||||||| |||.|  . 
eiserygdveikvekiverndysvrk.lvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TAAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHA
 | |...|  .. |. ..| .|||.|  |. ..|| .. . |.  |... 
iavrqlree.ivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_PTPN13_pd Subfamily PTPN13 262-510 3.1e-56 185.6 In-house 25-267 (273) alignment 
Range on Protein: 262-510
Range on HMM: 25-267/273.0
ETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDdYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVS
 . . ...  .    |||. ...|||. || | .    |||||.||  |      .||.| ||  . .|||.||.||.|..|.|. ..  .||       
pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk..vkchr

YWPEDKGAAQKFGD-ISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrkTQIPIVVHCSAGIDRTG
|||| |.   |  . . |.|      |  | | ...... ... | ..||.|..||. |||||.  ||||. ||.. ..     . |||||||||| |.|
ywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsG

VFCLVYTAAREINEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
..  ....   |.  . . |. ..|.||| ||. ..  |.|  | | ||| 
tlitidvvlglierdkef.dvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPN12_pd Subfamily PTPN12 253-517 1.6e-55 183.0 In-house 19-282 (290) alignment 
Range on Protein: 253-517
Range on HMM: 19-282/290.0
KELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
|. ..|.. .. . . . .     |||. ||.|||..|| |. ..    .|||||.||| |   .  .||.|.||   |.||| |..|.. .|.||.  .
klsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCre

PATGKgsTNFVSYWPEDKGAAQKFGDISVSLQSKRTTD-YHVERIIHLTHLptRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPI
   ||  .    |||| .. . .||...|.|......|  .. | .....   .. |... ...||||. |||||.  ||..|..|.....   . ..|.
velgk..kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPl

VVHCSAGIDRTGVFCLVYTAAREINEGHG--IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALA
|||||||. |||. . .  . . .....     |. ..| .|| ||  ..  ||| .. | |.. . .. |.
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_PTPRA_pd Subfamily PTPRA 274-511 1.2e-54 180.4 In-house 58-294 (330) alignment 
Range on Protein: 274-511
Range on HMM: 58-294/330.0
YSVKNRHPDIMPYDHNRVCLR---GT-RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDkGaA
   ||| ..|.|||..|| |    |.   ||||||||.        |||.| |.. ...||| |..||... ||||       .  .    |||.. | .
nkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy.kekdkfiaaqGPkeetvedfwrmiweqksativmlte..lkerkeekcaqywPde.G.l

QKFGDISVSLQSKR-TTDYHVERIIhLTHLPT----RQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsQQRKTQiPIVVHCSAGIDRTGVFCLV
  .|.| |... .  . || |  .. ...||     .. | .. . ||.||..|||. |  .|... .|..   .|.... |||||||||. ||| |. .
vtyGnirvevedetvlvdytvrkfl.vqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl..nqqsag.pivvhcsaGvGrtGtfivl

YTAArEINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
 .   |  .  .. |. ..||.|||||  |.  .|| .| | ..| |
davl.ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 276-512 1.2e-54 180.2 In-house 11-242 (250) alignment 
Range on Protein: 276-512
Range on HMM: 11-242/250.0
VKNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVVPTsPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGstnFVSYWPEDKgaAQK
 |||. ||...|. || |  ..     |||||||..    .   |||||.|||....||| ||.|.... |||| .   ..|    .  ||| .|  |.|
eknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt...yhqywPvek..aek

FGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREI
.||. ||| || .    . | . |..    . |.. .|.|..||. |||      |.....||.  |||.  . |..|.||||. |.| |. ...    .
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqa..sqqqagnaPvivqCsaGvgrsGafiaidavlerl

NEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
.. . . |. .|.|.|| .|  ..  .||  | | .|| . 
kkekvv.dvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 260-512 6.8e-54 177.8 In-house 30-277 (315) alignment 
Range on Protein: 260-512
Range on HMM: 30-277/315.0
DRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCL----RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGS
| .. .  .|  .    |||. .|.|.|..|| |        .||||||.|| |  .  ..||.|.||. |..||| ||...... |||.  |    | .
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

TnfVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIhlTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPIVVHCSAGI
     |||. |. . .|| |.|.| |  ..   | | .  .   . . ||.|  ||| ||. ||.   . ||..| ||.. .    | . ...||||||.
c..rqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadng...kkefsllvhcsaGv

DRTGVFCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
 ||||.. .     .|....   |. ..||.|| .|  ..  .|.  | |||.| . 
GrtGvvisidevvaqikrtr.svdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Ptp69D_pd Subfamily Ptp69D 265-515 1.1e-53 177.4 In-house 39-289 (307) alignment 
Range on Protein: 265-515
Range on HMM: 39-289/307.0
QFSIAIARCYSVKNRHPDIMPYDHNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVS
. ...      .|||..||...|..|| |. .      |||||||||     .  ||| |.|..  ..||| |. ||.  .||||     | |   .   
stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn..lteknrkkcak

YWPEDkgAAQKFGDISVSLQSKRTTDYHVERIIHLTHLP-----TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPIVVHCSAGI
|||..    ...||| | | |.........| .....         . | ..  ..|.|... || ..  ||..|..|.. ....   . ||||||||| 
YWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGv

DRTGVFCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHA
.|.|.|  .     .... .  .|| ..||.|| ||  ..   || .| | |.| |  ..
grsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRK_pd Subfamily PTPRK 276-510 1.8e-53 176.4 In-house 45-275 (314) alignment 
Range on Protein: 276-510
Range on HMM: 45-275/314.0
VKNRHPDIMPYDHNRVCLRGTRDD----YINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDkgaAQK
 |||  ||..||. || |  . .|    ||||..| |    .  ||.|| |||  ..||| .||..... ||||     . .|  . . |||||   ...
eknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltel..vevgrvkClkyWPed...tev

FGDISVSLQSKRTTDYHVERIIHLTH--LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqrkTQIPIVVHCSAGIDRTGVFCLVYTAaR
.||| | | .  .    | ||  ...   .  ..|.. ..||..||...|| |   ||... .|.. . .   .. .||||||||  |||.|. . .   
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidiv.l

EINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
.. | .|. |. ..||.|| ..  |.  .|| || ||.|| 
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPRN_pd Subfamily PTPRN 241-509 3.4e-53 175.3 In-house 24-289 (297) alignment 
Range on Protein: 241-509
Range on HMM: 24-289/297.0
MLSGPTVIERLWKELTNYQDRETRQfSIAIARCYSVKNRHPDIMPYDHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYE
 |. .. .|. |. |..|.  .. . ..| |  .  |||. ...||||.|| |.     ...||||||.| |  | .|..||||.||  .. ||| ||.|
hlknkdrlekewealcayeaepstk.evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvwe

QQASIIVMLLSKpaTGKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVeRIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSY
| . .||.| .   . .| ..   |||..  .  .. .. .  .   . || | | ..|  | |.. ||.| . | .||| |||.|.  ||.|   |.  
qGvvvivnltrl..eeegvkqckrywpdeGsevyhiyevhlvsehiwcddylv.rsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks

HsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
.   |    |||||||.|  ||||..|.      .. |    ||   ...|| ||  ..  |.|..| . |. 
y...rGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 275-511 4.1e-53 175.2 In-house 44-275 (515) alignment 
Range on Protein: 275-511
Range on HMM: 44-275/515.0
SVKNRHPDIMPYDHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQ
  |||. .|.||| .|| |         ||.|||.|. .  .  ..||.|.|.. |..||| .|.... . |.|.  .    |   .   |||.  | . 
fkknryknilPydsvrvklevindnPhsdyfnasyipsf.dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdk..ikcgkyWPdkpgdsv

KFGDISVSLQSKRTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRktqIPIVVHCSAGIDRTGVFCLVYTAARE
||| |.|.| |  .    . | .....    ..||.|  .|| ||. |||     ||..| ||.. |.|      |...|||||. ||||.. .     .
kfGsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvvah

INEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
..... . |. ..|...| .|  ..  .||  | |.|.| .
akttrmv.dvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 273-511 8.8e-53 174.3 In-house 50-283 (297) alignment 
Range on Protein: 273-511
Range on HMM: 50-283/297.0
CYSVKNRHPDIMPYDHNRVCLRGTRDD----YINASFIKDVVPtspCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDkGA
    |.|. .|.||| .|| |. . ||    |.||||.| .      .|.|| | . ...||| ||...|.|.||||  .  . |   .   ||... | 
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk...kcaryWsdk.gv

AQkFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPS--SPGVLLQFIDEVQSYHSQQRKTqiPIVVHCSAGIDRTGVFCLVYT
.. |||.|| |.|       ..| ...|.  ... | .   ||. ||.  |.   |   ||..|.||.  .||. ..  |..|||.||. ||||.. .  
tt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltids

AAREINEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
   |... . . || ..||||| .|  ..  ||| || | |.| .
vvaeakrekev.difglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 266-513 6.6e-51 167.9 In-house 36-284 (290) alignment 
Range on Protein: 266-513
Range on HMM: 36-284/290.0
FS--IAIARCYSVKNRHPDIMPYDHNRVCLR---GTRD---DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTN
..  ....   . .||  .|..|| ||. ||   | .|   .||||..||.    .  .||||.|..  | ||| ...... .|||||..    ||  ..
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegk..vk

FVSYWPEDkGAAQkFGDISVSLQSKRTTDYHVERIIHLTHLPT-RQMRTITHLQFTAWPEFG-VPSSPGVLLQFiDEvqSYHSQQRKTQIPIVVHCSAGI
   |||.  .... .| .|. |.. .|... .|| .....  .  . ...|..|.|.|.. | |.   ..||..  |   |. | .... .||||||...
CqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi.ee..myktqrkrgntsivvHCSdtv

DRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
 |..||| ..|.    .   |  |. ||.|..| |.  ..  ..|... .. .| |  
grsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 265-512 7e-51 168.3 In-house 39-288 (325) alignment 
Range on Protein: 265-512
Range on HMM: 39-288/325.0
QFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRD----DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpAtgKGSTNFVS
 . .|       ||| ......|..||.|   .|    ||||||...| .     |.|.||||  ..||.| .|.. ..|..|.|       .|  .   
akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.d..lgkdrcav

YWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQR---KTQIPIVVHCSAGIDR
|||.. | ...|| . |.|..  .   .| |....      . |..  .|. .|...||.  |  |. ... |.  . . .   |.  ||.||||||. |
ywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGVFCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
||||  .|.|. .. |     || ..||||| .|  |.   .|  . |.|.  . 
tGvfislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRG_pd Subfamily PTPRG 248-510 5.7e-50 165.1 In-house 21-285 (563) alignment 
Range on Protein: 248-510
Range on HMM: 21-285/563.0
IERLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRD-----DYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASII
... ...|..    .. . . . ...   |||. .|..||. || |... .     |||||..|.     |  ||||| ||.  ..||| |..||...||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy.qkskafiatqgplkdtfddFWrmiWeqnvaii

VMLLSKpaTGKGSTNFVSYWPEdkGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTR--Q----MRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsy
||.     . .|  .   |||.    ....| ..| |... .. .  .| . . .|  .  .     ..... ..| ||. |||...   |.|.      
vmitnl..vergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks...

HSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
   ....  |||||||||. |||... . |  ..|.. . . .. ...|..|.||  .. ..||  | .||.| 
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 262-512 3.3e-48 159.1 In-house 35-278 (287) alignment 
Range on Protein: 262-512
Range on HMM: 35-278/287.0
ETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSY
.  .  ..||     |||  .|...| .|| |.|...|||||.||.     .  ||....|.   . .|| .. ... ..||||  .  .         |
redevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgy.kekkafiiaesPmfntarnfWkliddrnvtaivmlcqeken..deevcyqy

WPEDKGaaQKFGDISVSLQSKRTTDYHVERIIHLTHLP-TRQMRTITHLQFTAWPEFG-VPSSPGVLLQFiDEvqSYHSQQRKTQIPIVVHCSAGIDRTG
|||.|     .|. ...| .. ...  .|| .....   . . ....  |.|.|.. | |..   .||.. .|   |..|..... .||||||... |..
Wpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.ee..myktqrkrgntsivvhCsdtvGrsa

VFCLVYTAAREInEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
.|| . |. ..  .  |. |. ||.|. | |.  ..   || || .|..| | 
mfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 274-516 3.8e-47 155.5 In-house 20-268 (270) alignment 
Range on Protein: 274-516
Range on HMM: 20-268/270.0
YSVKNRHPDIMPYDHNRVCLRGTRDD----YINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLlsKPATGKGSTNFVSYWPEDKGA-
 .. ||. ||.|  . ||.|   ..|    |||| ... .   .  .||...||. .|..|| |..|.... |||.   . . || ..   |||....  
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt..tgleEkgrkkCerYWpaepkek

-AQKFGDISVSLQSKRTTDYHVERIIHLThlPTRQMRTITHLQFTAWPEFGVPSSPG------VLLQFIDEVQSYHSQQRKTQiPIVVHCSAGIDRTGVF
 . ..|.|.|  .|.. .. .. . ..|.   . . | ..| ....||. |||....       ||. . .|. ......|.. |..||||||..|||..
vkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtl

CLVYTAAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHAL
 .. .| | ..|  . .|. .....|| .|  ...  || .| | |.. ||....
ialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 276-510 6.9e-47 155.3 In-house 63-289 (319) alignment 
Range on Protein: 276-510
Range on HMM: 63-289/319.0
VKNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLskpatgkgSTNFVSYWPEDKGAAQK
 |||  .|...|.|.| |. .      |||||||..        .||.| ||. .|.||| |..|...| ||.|               ||| .    ..
dknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt........kdkcsqywplkivikee

FGDISVSLqsKRTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAARE
 ....|..     |. .| | |.|..    ...| ||   |  ||. ||| .|  |..... |.  .|.. . . .||||||||. ||||.  . .    
rfkvkvds..veetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.nhranivvhcsaGvGrtGvyivldvlldr

INEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
..|     |. ..|. || ||  .. .  | || | |.| 
mke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 277-510 1.6e-46 154.1 In-house 28-253 (284) alignment 
Range on Protein: 277-510
Range on HMM: 28-253/284.0
KNRHPDIMPYDHNRVCLRGTR----DDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLskpatgkgSTNFVSYWPEDKGAAQKF
|||  .|...|.|.| |. .      ||||||||.        .|||| ||. .|.||| |..|...| ||.|           .   ||| .    .. 
knrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt........kdkcsqywplkivikeer

GDISVSLqsKRTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREI
....|..     .. .| | |.|..    ...|.|.   |  ||. ||| .|  |..... |.  .|.. . . .||||||||. ||||.  . .    .
fkvkvds..veeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcsagvgrtgvyivldvlldrm

NEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
.|     |. ..|..|| ||  .. .  | || | |.| 
ke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 276-509 1e-45 150.8 In-house 5-236 (237) alignment 
Range on Protein: 276-509
Range on HMM: 5-236/237.0
VKNRHPDIMPYDHNRVCLRGT--RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGaAQKFG
.|||. .|. |||.|| |.|.    |||||...|..  |   .||.| ||..| .||| ||.... |.||||       .       |||. .   . .|
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglie..gnelkchkywpstdq.paayg

DISVSLQSKR-TTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIN
 ..|||. |   .|| |  ..  ..|  ...| |   |||.||. |||     ||.|  ..   .|.      | ..|||||. |||.| .. .  |. .
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlrqak

EgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
| . . || . |. .  .| ..|  |.|  | ...||
e.kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 265-510 1.6e-44 146.9 In-house 24-264 (283) alignment 
Range on Protein: 265-510
Range on HMM: 24-264/283.0
QFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIK--DVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLlSKPATGKgSTNFVSYW
.  || |.    |||. .|.|.| .|| |.    |||||.||   .    .  .|..|.||.    ||| ||...... |||| .|   ..   .   ||
dadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml.tklqedl.rikCsqyW

PEdKGaAQKFGDISVSLQSKRTTDYHVERIIHLTHL-PTRQMRTITHLQFTAWPEFGVPSSPGVLLQFiDEVQSYhsQQRKTQIPIVVHCSAGIDRTGVF
|. .| ....|.  |.|.   | .  . . . | .   ...   ..| |.  | |.|  .    |..| . |.|   |... . |||||||.|| ||.||
Pk.rG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvisl..qteskkgPivvhCstgiGrtavf

CLVYTAAREINeGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
. . ..  ..   . . |...||| .| ||  .. ...| |. ....| 
iaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 275-509 1.6e-43 143.8 In-house 50-276 (315) alignment 
Range on Protein: 275-509
Range on HMM: 50-276/315.0
SVKNRHPDIMPYDHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDkgaAQ
  |||. .|..||. || |         ||.||.||.        .||.|.|.  |..||| .|.|.. . |||| .     |   .   |||..     
kqknryiniiaydksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegek..rkaekywpdk...kv

KFGDISVSLQSKRTTDYHVERIIhlTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRktqIPIVVHCSAGIDRTGVFCLVYtAARE
 .| |.|...|.   .    | .  .     ..|..  |..|.||. ||| .   |...|  |. .| ..     .||||||||. ||| |. .  |  .
iyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitld.avld

INEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
  |   . |. ......| .|. |..  || .| |||.|
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_CG7180_pd Subfamily CG7180 277-511 1.4e-42 140.4 In-house 45-289 (296) alignment 
Range on Protein: 277-511
Range on HMM: 45-289/296.0
KNRHPDIMPYDHNRVCLR---G-TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDKgaAQKF
|||.....|||.||| |.   |  ..|||||...   .     .| |.|| . ....|| .||....| .|.|  ..   |    . ||||..    ...
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak...mypsywpnks..keqy

GDISVSLQSKRTTDYHVERIIHLTHL----------PTRQMRTITHLQFTAWPE-FGVPSSPGVLLQFIDEVQSYHSQQ--RKTQIPIVVHCSAGIDRTG
|.| | . ....    . | ..||.            . . |.....|.| |.    ||.|   |....  |...  .   .... |.||..| |  |.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

VFCLVyTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
|.. .  |. |  | ..  |. . ||.|| .|. .. ..|. |. || .| .
vylai.danlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 264-513 3.3e-40 132.7 In-house 28-278 (287) alignment 
Range on Protein: 264-513
Range on HMM: 28-278/287.0
RQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRD---DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVS
  |  |       |||. |..|.|..|| |  . .   ||||| ..         |||.|.|.  ...||| .|.|.... ....  .    ..  .   
atfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtre..veearlkcyk

YWPEDkGAAQKFGDISVSLQS--KRTTDYHVeRIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTQ--IPIVVHCSAGID
||||      . |  || | .  ..  .| | | . | .| ||. | .  |.. .||. ... .   |..|. .|. .   .|...   |.|||...|| 
ywPer.evPmrvGGysvvlldydikePeygv.ralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGVFCLVYTAAReINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
|.|..  ...  .   |  |  |. .|| .|| .|. ..    ||...|.|.  | .
rsGillatlvlvs.rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 254-512 3.5e-40 132.6 In-house 20-293 (301) alignment 
Range on Protein: 254-512
Range on HMM: 20-293/301.0
ELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRD------DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
. .. .. | .. .. .    .. ||. .| .||.||. |. ...      .|||||.|...   .  |||.|.|..  | ||| ...... . |||.  
qykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtn

KPATGKGStnFVSYWPEDKGAAQKFGDISVSLQSKRT-TDYHV----------------ERIIHLThlPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFI
.  . | .     |||. .   ..|| ..| |... .  |. .                || .. .   ... .... || | ||. ||   |   || |
lkegtksk..ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvk..sdksswdvlqlqvtdWpqdGvvreprtvLqvi

DEVqsYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTaAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
|.|   | ||.    |.|||||... |.||.| |   . |     |. |. ||.| .| ..  ..   ||  . ||.|  | 
ddv..ihrqqkigggpvvVHCSdtVsrsGvYcsvsi.glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0041856 (Phosphotyrosine protein) phosphatases II 277-513 2.4e-38 126.9 In-house 4-172 (182) alignment 
Range on Protein: 277-513
Range on HMM: 4-172/182.0
KNRHPDIMPYDHNRvclrgtRDDYINASFIKDVVPTSPcFIATQAPLQPSLNDFWLMVYEQQASIIVMLLskpatgkgstnFVSYWPedkgaaqkfgdis
|||..||.||||.|        |||||...    |..  |||||.||. ...||. |..|.. ..||.|             . |||             
knrysdilpydhsr......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt...........eelywp.............

vslqskrttdyhveriihlthlpTRQMRTITHLQFTAWPEFGVPSsPGVLLQFIDEVQSyhsqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAREineghG
                       .. .|........ || .|||. .  ||.||.||..        . |..||||||..|||.... |   .      |
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

iADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
  .....|| .| .|  |.   .|. | ..|.|.. .
.vsleeavklvrsrRpgmvitpnqyfflqlallelll
0051429 (Phosphotyrosine protein) phosphatases II 298-515 6.8e-38 126.2 In-house 4-228 (272) alignment 
Range on Protein: 298-515
Range on HMM: 4-228/272.0
DDYINASFIKDVvpT----SPCFIATQAPLQPSLNDFWLMvYEQQASIIVMLLSKPATGKgsTNFVSYWP----------EDKGAAQKFGDISVSLQSKR
..||||....    .       ......||. . .||| . .|.. . ||.| |    |.   ..  |||          .|      .|...| |.|. 
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgr..lkcdrywpgirylhlpilddsaptilygalrvtllsee

TTDYHVERIIHLTHL-PTRQMRTITHLQFTAWPEFGVPSSPgvLLQFIDEVQSyhsqqrktQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIAD---
...... | . ||.| .. ..|...||..|.|| .|||...  ||........        . |..||||||.||||......  .. ...   ..|   
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----IPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHA
    . ..|..|| ||....   ||..| |.|.| ..|  
tnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 255-509 3.7e-36 119.4 In-house 26-233 (392) alignment 
Range on Protein: 255-509
Range on HMM: 26-233/392.0
LTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLsKPA
. .  . .  . ..|       |||. .|.||| .|| |      . .||.|||.|. .  .  ..||.|.|   ||.||| ||...... |.|.  |  
fhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf.dnekayiasqgpnaaslddfwrmvfqenvttiamvt.klk

TGKgstnfvsywpedkgaaqkfgdisvslqskrttdyhveriihlthlPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqiPIVVH
 |                                                 ..||..  .|| ||. .||     ||.|| ||.. . |  .   |...|
egd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth...pliih

CSAGIDRTGVFCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
||||. ||||   . .     ..   . |. ..| ..| .| .|.  |||  | | |.|
csagvgrtgvvisidsvvahakk.trmvdvfnfvtnirrkrpymvqtkeqyafiygavl
0043147 (Phosphotyrosine protein) phosphatases II 297-505 6.2e-35 115.8 In-house 4-154 (172) alignment 
Range on Protein: 297-505
Range on HMM: 4-154/172.0
RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpatgkgstnfvsywpedkgaaqkfgdisvslqskrttdyhveriihlT
..||||||... ..   . |||||.||.  |.||| |..|.. ..||.| .                                                .
gsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

HLPTRQMRTITHLQFTAWPEFGVPsSPGVLLQFIDEVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAreinegHGIaDIPQVVKKLRLQRRWMIS
..|.  .|.. ..... || .||| .. .||.|.. .....  ... . |..||||||..|||.... |         .|. .. ..|. .| .|.... 
ydpellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavq

EKEQLKFSY
 ..|..| |
npsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 298-505 7.2e-35 115.6 In-house 2-163 (174) alignment 
Range on Protein: 298-505
Range on HMM: 2-163/174.0
DDYINASFIKDVVPTSpCFIATQAPLQpslndFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEdkgaaqkfgdisvslqskrttdyhveriihlth
.||||||... .. |.  .||.|.||.     || |..|.. ...||||.     .|.. .  ||||                                 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleeke..lglykcinywpe.................................

LPTRQMRTITHLQFTAWPEFGVPSSPGvLLQFIDEVQSYHSQqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREINegHGIADIPQVVKKLRLQRRWMISE
|..   |.. ..... || .|||...  ||.|...|....|.  . . |..||||||..|||.... |   | .   ..  |. ..|..||||| .|.  
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqt

KEQLKFSY
 .|..| |
psQyrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 270-509 1.2e-34 114.5 In-house 43-276 (439) alignment 
Range on Protein: 270-509
Range on HMM: 43-276/439.0
IARCYS-VKNRHPDIMPYDHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstnfvsYWPE
.|. |.  |||. |. ..|| || |.         |||| .||    .   .||||.| . . .||| .|.|.... ||||     . |       ||| 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.......ywps

DKGAaqKFGDISVSLQSKRTTDYHVERIIHL--THLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqQRKTQIPIVVHCSAGIDRTGVFC
|. .   .|||.|  . .     .| | ...   .  |.. ||. .....|||.  ||.    .|.|.  ..|    ...   |.|||||||. |||   
daev..cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan..dkeeygpvvvhcsagvGrtGtii

LVYTAAREINeGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
 .  |  ...      ||  .|| || ||. |. .  |  | |.|.|
aldialeqlk.lenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 262-516 5e-33 109.2 In-house 21-263 (267) alignment 
Range on Protein: 262-516
Range on HMM: 21-263/267.0
ETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpatgKGSTNFVSY
.. . |  ||     .||  | .|||..|| || . ..|||||.. .   |   ||.|| ||. .  ||. .. .|. ..||.|        .  |   .
tsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyv.egyktknafivtqdplkntitdfltvihdqkvpvivlltk.....vftdnirlf

WPEDKGAAQKFGDISVSLQ-SKRTTDYHVerIIHLTHLPTRQMRTITHLQFTAWpEFGVPSSPgvLLQFIDEVQSyHSQQRKTQIPIVVHCSAGIDRTGV
||   | |.|. |..|     |   ||..  |    ..     . .|   .  | .  .   |   |. .  . . . |  . . |.||.||.|. |.| 
wPPkmgqakkyqdltvehslekeendyqi..itlelkfknesahnvtlyyykkw.nintnnkp..ylkplfgila.knqlengnrPlvvacsdGvGrsGt

FCLVYTAAREINEgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHAL
|  ...  . . .  |..|| . ..|.| ||  ..  ||.  . .. .  ||.  |
flvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
0049772 (Phosphotyrosine protein) phosphatases II 274-512 5.9e-32 107.0 In-house 46-280 (314) alignment 
Range on Protein: 274-512
Range on HMM: 46-280/314.0
YSVKNRHPDIMPYDhNRVCLRG---TRDDYINASFIKDVvptsPCFIATQAPLQPSLNDF----------WLMV--YEQQASIIVM--------------
   |||..||.|.| |||.| |      ||||||... .      |||||.||.  ..||          | ||  ....  .|||              
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LLSKPATGkgstnfvSYWPEDKGAAQKfgdisvslqskrttdyhveriiHLTHLPTRQMRT-ITHLQFtAWPEFGVPsSPGVLLQFIDEVQSY
       ||. .  |       .....   .  |                        .. | .  |. |..|..  .| ...| ..  ...|.. ....
aAlgKtpllildgng.......neptaadlellk......................eelydpelferlgikylri.pvpDgsap.lledfdeflefieea

hsqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIneghGIaDIPQVVKKLRLQRR-----WMISEKEQLKFSYDAILCYA
     ... |..|||.||..|||.|....   .      |. .. .... .||.|       .|   ||. | ..|.| | 
.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 275-514 8.6e-32 105.1 In-house 49-289 (305) alignment 
Range on Protein: 275-514
Range on HMM: 49-289/305.0
SVKNRHPDIMPYDHNRVCLRGTR-DDYINASFIKdvVPTSP-CFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGAAQKF
. |||. |.   |.||| |.|.   .|| | ..    || |  || |||||. .  ||| | ....   | ||       ||.   . |.. ...   .|
agknrykdvgcldnnrvklegpwpheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcn..llekgakkcleyfaskdkdvlef

G----DISVSLQSKRTTDYH------VERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDevqsyhsQQRKTQIPIVVHCSAGIDRTGVFC
      ||| ..|  | ...      |.. . .   |  ..| .||  .  ||. |||..   .|...        . | .. |||||||||| |||   
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.......karpskgpivvhcsagigrtgsvv

LVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
..     .. .|. | |  ....|.| ||   |   .|  | .. || | |.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 271-509 1.9e-31 104.0 In-house 5-238 (239) alignment 
Range on Protein: 271-509
Range on HMM: 5-238/239.0
ARCYSVKNRHPDIMPYDHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEdk
 |    |||. .|. |||.|| |       . ||||||...|   .  ..||||  ...|  ||| |.....  .||||       |   .   |||.  
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk..kkchqywpd..

gAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhsQQRKTQIPIVVHCSAGIDRTGVFCLVYT
 .. |. .. |.|.       .. | . ....   . | . . .|| ||. |||     .| .  ..     .      | |.|||||. ||| | .. .
.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvida

AAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
  |. .. .   || . || .| .|  |.   ||  | . |.|
mlrqakkqk.tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 271-509 2e-31 104.0 In-house 4-237 (239) alignment 
Range on Protein: 271-509
Range on HMM: 4-237/239.0
ARCYSVKNRHPDIMPYDHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEdk
 |    |||. .|. |||.|| |       . ||||||...|   .  ..||||  ...|  ||| |.....  .||||       |   .   |||.  
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk..kkchqywpd..

gAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhsQQRKTQIPIVVHCSAGIDRTGVFCLVYT
 .. |. .. |.|.       .. | . ....   . | . . .|| ||. |||     .| .  ..     .      | |.|||||. ||| | .. .
.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvida

AAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
  |. .. .   || . || .| .|  |.   ||  | . |.|
mlrqakkqk.tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 272-495 2.6e-31 103.4 In-house 54-266 (290) alignment 
Range on Protein: 272-495
Range on HMM: 54-266/290.0
RCYSVKNRHPDIMPYDHNRVCLR-GTRDDYINASFIKDvvpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQ
     |||. |..  |  || |. |   ||. | ..|    . . || || .|. .  |.| || ..... ||||      ||  .    |.|| .| . 
ntefkknrykdvvcndktrvilkdGydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk..akceqyypekeGevl

KFGDISVSLQSKRTTDYHV-ERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAR
 ||.|.|    . . | ..  ... . .  . .   . ||.  .||.  |. |   ||. .  .       ||.  |.|||||||| ||| |  . ....
tfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.......rkasGpvvvhcsaGiGrtGtfvaievglq

EINEGHGIaDIPQVVKKLRLQRRWMI
 . .|. . |. ..|. ||  |   .
illdGkel.dlldlvralrnsrlnsv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 274-512 7.2e-31 101.9 In-house 55-289 (305) alignment 
Range on Protein: 274-512
Range on HMM: 55-289/305.0
YSVKNRHPDIMPYDHNRVCLR-GTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKF
   |||. |.   |.. | |   .  ||| | ..   .     ||..| ||. ....|| || ...   ||||     .||   .   |||  .|  ...
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgk..lkcaqywpaaqgeklel

--GDISVSLQSKRTTDYHVERIIHLTHLP--TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIdevqsyhSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAA
  | .   .   .  .   |  | | .|     |  .. |||.| ||. |||      |...       |  | ...|||||||||| |||    .    
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell.......sairgskvpivvhcsagigrtgtivaieyil

REINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
 .| | .    .|..|| || || . | .  |  | .  .| | 
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 253-511 1.1e-30 101.7 In-house 20-276 (307) alignment 
Range on Protein: 253-511
Range on HMM: 20-276/307.0
KELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPA
 |...  ...    ..   .. . |||. |.   |..|. .   |   ||| | ..   .     ||..| ||. .  .|| |. ...   ..||     
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiai.kpkkficaqgplentqysfwamaiqekvesvimlckvie

TGKgsTNFVSYWPEDKGAAQKFGDI----SVS-LQS-KRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPgvlLQFIDEVQSYhsqqRKTQ
..|   .   ||| ..|  . ||.     ||. | . | . | ..  .  |    ... |||.|||.. ||. |||      |  |. ...     |  .
lak..ikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleav....rydt

IPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
 |.|||||||. |.|    .      . .|    |. ..|..|| ||.. | .. |  . .  .| |
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 258-432 2.9e-30 100.2 In-house 12-192 (297) alignment 
Range on Protein: 258-432
Range on HMM: 12-192/297.0
YQ-----DRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRG--TRDDYINASFIKDV-VPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
 .     .... .|| |       |||. ||. .| .|| |..  |  ||||| ..     ..   .| .| ||. ...||| .|.||.  .|||.    
ekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

ATgkGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDE
    |    . |||. ..  .| ||. |   |. . ...   .  |. .   . | ..| || .||. ||||    | .|  .
ed..GrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
PTPc_DSPc_SM00012 405-509 2.4e-29 97.0 In-house 1-104 (105) alignment 
Range on Protein: 405-509
Range on HMM: 1-104/105.0
TITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFS
|..|...|.||..|||...  .|.....|.. .... . . |.|||||||..|||.|...... . ......  || |.||.|| ||..|....||  | 
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDAIL
|.|.|
yrall
0046846 (Phosphotyrosine protein) phosphatases II 299-511 7e-29 96.2 In-house 13-172 (176) alignment 
Range on Protein: 299-511
Range on HMM: 13-172/176.0
DYINASFIKDvvptsPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQkfgdisvslqskrttdyhveriihlthl
|||||..|       ...||||.||  .| ||. |..|.. ...|.|..   .|.   ..  |||| ...                              
dyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgr..lkcpnywpeleklgi............................

ptrqmrtitHLQFTAWPEFGVPSSpGVLLQFIDEVQSYHSQQrktqIPIVVHCSAGIDRTGVFCLVYTAAReinegHGIADIPQVVKKLRLQRR-WMISE
         . ... ||..|||..   ||......... ..      |..||||||| |||.... |   .     .   .. ......| ||. ...  
.........qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqt

KEQLKFSYDAILCY
 ||..| |...| .
peQyrflyefelll
0051082 (Phosphotyrosine protein) phosphatases II 298-507 3.3e-28 93.6 In-house 3-148 (151) alignment 
Range on Protein: 298-507
Range on HMM: 3-148/151.0
DDYINASFIKDVvptspcFIATQAPLQpslnDFWLMVYEQQASIIVMLLSKPATGkgstNFVSYWPEDKgaaqkfgdisvslqskrttdyhveriihlth
.||||.|.. .       ......||.    ||. ...|.. . ||.| |.. .|    .. .|.||                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg....ycpeylpelg...............................

lptrqmRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhsqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREineghgiADIPQVVKKLRLQRRWMISE
      ....|.... ||..|.| |.  .|.|......      | . |..||||||..|||.....|  ..         .. .... .||.|  ..  
......ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp

KEQLKFSYDA
..|  | . |
nqqflfqlfa
subfamily_ptpA1_pd Subfamily ptpA1 275-465 1.6e-26 88.0 In-house 48-250 (418) alignment 
Range on Protein: 275-465
Range on HMM: 48-250/418.0
SVKNRHPDIMPYDHNRVCLRGTRD----DYINASFIKDVVPTSpcFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQ
. |||. .|.| .| || |.  .|    ||||| .|    |    ||.|| ||  .. ||| ||.|... |||||  .    .   .   ||||. |  |
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsrese..ncrikcdrywpeqiggeq

---------KFGDISVSLQSKrTTDYH---VERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHS---QQRKTQIPIVVHCSAGI
          ||  || |      |     . | |.||     . | ||. |.  ||.. .|     . |..  .   .         ..||.||||||.
fsiygngnevfgtysvelvev.iqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

DRTGVFCLVY
 ||| ||   
grtgtfctav
0049260 (Phosphotyrosine protein) phosphatases II 314-506 4.6e-25 83.5 In-house 9-144 (152) alignment 
Range on Protein: 314-506
Range on HMM: 9-144/152.0
PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWpedkgaaqkfgdisvslqskrttdyhveriihlthlptrqmrtitHLQFTA
  |||||.|.  .|.||| |..|.....|||| .     .|   .  |.                                             . ... 
fefiatqgpgpntladfwrmlkelgittivmltelle..lgklkceqyi.............................................qylhlp

WPEFGVPSSPGVLLQFIDEVQSYhsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAreineghGIADIPQVVKKLRLQRRWMISEKEQLKFSYD
|| .|||... .||.... .. .   ... . |..||||||..|||.... |             .. ..|. .| .|  ..  ..||.| |.
wpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 268-511 1e-24 82.1 In-house 34-270 (288) alignment 
Range on Protein: 268-511
Range on HMM: 34-270/288.0
IAIARCY---SVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPE
| |.  .   ....|. ..   |  || |    | ||.|  .    .    .| .||||.  .. .| |. |..   ||||       ||  .   |.| 
idiidsfianptrdryenlprcditrvklsddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlce..llekGkeksaeyfPs

DKGAAQKFGDISVSLQSKRttdYHVERIIHLTHLPTRQM----RTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGV
 .| . ..| .    . ||     ........ |   .       . .| .  |.. ||| .    |.... .       ...| |||||.|||. ||| 
klGekarigrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgt

FCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
. |.  |.. .        |.....||| .|.  |  . |  . .  .| .
lililialeslrldd.flgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 290-516 1.3e-24 81.9 In-house 34-263 (290) alignment 
Range on Protein: 290-516
Range on HMM: 34-263/290.0
RVCLRG----TRDDYINASFIKdvVPTSPCFIATQAPLQPS-------LNDFWLMVYEQQASIIVMLLSKPATGKGSTNF--VSYWPEDKGAAQKFGDIS
|| |.|      |||| |....  .|   ..|.||.|..         ...|| |. . ..  .|||       .. ..|    | ||  |   ||....
rvvLkgygkrfnddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VSLQSKRTTDYHVERIIHLTHLPTRQMrTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsqqrktQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHG
|. .|| . |   .| . ...   ... |.|| ..  | .  |. .. .||. |. |. .       . |..|||  || |  ..  .  .   | | .|
vkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHAL
   . .|.|.|| ||  .|.....| |   .|. .| ..|
svkledvlkalrkqralaitsalelafvdagivllaievl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 275-493 6.3e-24 79.1 In-house 38-249 (281) alignment 
Range on Protein: 275-493
Range on HMM: 38-249/281.0
SVKNRHPDIMPYDHNRVCLRG-----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAA
  |||. .|   |  || |.         ||| | .|.  .     .| || | . .  ||| |....... ||||     | .   .   |.| .  ..
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr..ekcaeyfprnahcc

QKFGDISVSLQSKRTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAR
 .|  .||| .        |   . |..    . | |||  .  ||.. || |  |.|. . ..       |    | |.|||||. |.| .  |  | .
lqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrki.......rarstppvihcsagvgrsgtlmaveialq

EINEGHGIADIPQVVKKLRLQRRW
 |     . || |.| .||.  | 
sihshftlpdikqivshlrvtgra
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 233-513 1.1e-23 78.2 In-house 10-291 (310) alignment 
Range on Protein: 233-513
Range on HMM: 10-291/310.0
YVEGLNRKMLSGPT-VIERLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLR---GTRDDYINASFIKDVVPTSpCFIATQAPLQPSLN
|.. |.  ...     || | |.  . . ..   ..    . |  |||. |..  |  || |.      .||| | ..|     |  || .| ||| .. 
ylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs.tficsqgplqhtii

DFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEdKGAAQKFGDISVSLQSKRTTDYHVERIiHLTHLPTR-----QMR-----TITHLQFTAWPEFG
||| |.....|  |..|    .. .|  . |.|||   | .. .| | |.  |. . .. .  .  .| .|       |        .. ...  ||. |
dfwrmifqeraesilllck..vgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnl.avtfvpdnvpvdeqpanlkelrvslikwpnwpdrg

VPSSPGVLLqfideVQSYHSQQRKTqiPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
||      .      |   .| |.   | |||||||.||..| . .  .   ...|. . |. .|. .|. .|   |  . |  .     . .||
vpdekchtv.....pqrllaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkv.daeevktellksraiciqtelqyliidrvriifar
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 301-502 2e-23 77.6 In-house 78-271 (301) alignment 
Range on Protein: 301-502
Range on HMM: 78-271/301.0
INASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQS--KRTTDYHVERIIHLTHL
| | .|.     .  |||||.||. . .||| |.   .   ||||  |    |  .   .| | . .   . |  .. ...  .   .  ..| ....  
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve..kleekceeylpvkisekldigrfkikiknkelilnkkiskrtleveds

PTR-QMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIaDIPQVVKKLRLQRRWMISE
  . . ||.|| |.. |.. ||| |   | .... |       .|.. |||||||||| |.  |      |||..    | .. . .|.|| .|   .  
tgkfatrtvthyqysewtdrgvPkshaelfdlmelv.......kksekPivvhcsaGiGrsvafigteylareveadpti.eltealkhlrehrwngvqt

KEQLK
..|| 
nsqly
0044763 (Phosphotyrosine protein) phosphatases II 285-503 2.2e-23 78.2 In-house 1-162 (178) alignment 
Range on Protein: 285-503
Range on HMM: 1-162/178.0
PYDHNRVCLRGTRD----DYINASFIKdvvptsPCFIATQAPLqpslNDFWLMVYEQQASIIVMLLSKPATGkgSTNFVSYWPEDKGaaqkfgdisvslq
|.|..||.|   ..    ||||||.|       | ......|      |.. ...|.  . ||.| .    |    .   ||||. |             
pldrtrvllsnleglersdyinaseil......pglylgslpp....addlellkelgithivnlteelelg..flkcdpywpeeag.............

skrttdyhveriihlthlptrqmrtITHLQFtAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqiPIVVHCSAGIDRTGVFCLVYTAAREineghGIaDI
                         |..|..  .| .|||...  .|.|.. ........ .   |..||||||..|.|.... |   .      |. ..
.........................iqylhi.pipDhgvpdllehflefvefieealdekgg...pvlVHCsaGvgRsgtlvaaylmkkl.....gl.sl

PQVVKKLRLQRRwMISEKEQLKF
..... .| .|. ..   .||..
eeaielvrerRp.ivpnpgqlrq
0048076 (Phosphotyrosine protein) phosphatases II 372-508 2.4e-23 77.8 In-house 13-139 (145) alignment 
Range on Protein: 372-508
Range on HMM: 13-139/145.0
FGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqrktQIPIVVHCSAGIDRTGVFCLVYTAARei
.|.. . |. ..  |... ... ||. ..   |........ || .|||...  ||.|.. .......      |..||||||..|||.... |   .  
lgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmll..

negHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAI
   .|  .........| ||....   .||.| |...
...lg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 316-506 2.8e-23 77.1 In-house 6-197 (198) alignment 
Range on Protein: 316-506
Range on HMM: 6-197/198.0
FIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtGKgSTNFVSYWPEDKGAAQKFGDISVSLQSKRT-TDYHVERIIHLTHL-PTRQMRTITHLQFTA
.|||| ||. .| ||| ||.|  .  |||.       |  ...  |||  . .. |.| .||. ..  |  || .  .|           | |.| |||.
yiatqhplretladfwqmvwetgsghivmvnddqk.nk.eadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEFGVPSSPgVLLQFID---EVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGH-GIADIPQVVKKLRLQRRWMISEKEQLKFSYD
| |   |    ... |.    ||   .  ... . |..|||| |   ||||  .    |  .| .  . |. .| |.||  |  .||  .. .| |.
wkekttpnva.lfvgfvvasrevskky..eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 316-506 2.9e-23 77.1 In-house 7-198 (199) alignment 
Range on Protein: 316-506
Range on HMM: 7-198/199.0
FIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtGKgSTNFVSYWPEDKGAAQKFGDISVSLQSKRT-TDYHVERIIHLTHL-PTRQMRTITHLQFTA
.|||| ||. .. ||| ||.|  .  |||.       |  ...  |||  . .. |.| .||. ..  |  || .  .|           | |.| |||.
yiatqhplretmadfwqmvwetgsghivmvnddqk.nk.eadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEFGVPSSPgVLLQFID---EVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGH-GIADIPQVVKKLRLQRRWMISEKEQLKFSYD
| |   |    ... |.    ||   .  ... . |..|||| |   ||||  .    |  .| .  . |. .| |.||  |  .||  .. .| |.
wkekttpnva.lfvgfvvasrevskky..eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 277-511 6.5e-23 76.1 In-house 38-269 (285) alignment 
Range on Protein: 277-511
Range on HMM: 38-269/285.0
KNRHPDIMPYDHNRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGAAQKFGDIS
 ||. |.   .  || |.    ||| ||...        .|.|| ||  .|.||| |.|... . ..|| .      |  .   |.||  |   |||   
lnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg..gvekcalyypeklgevvkfgkye

VSLQSKRTTDYHVERIIHLTHLPTR----QMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIN
..|   .        .  || . |     .   . |.|   ||.   |     ....   |.         . ||.||||||. ||  |  .  |.  | 
itlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv....npkekpicvhcsagvgrtatfvgidyatirim

EGHGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
|   | .. ..|...|  |   .  . |. | |  .. |
enpni.emldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 275-524 1.2e-22 74.7 In-house 52-297 (302) alignment 
Range on Protein: 275-524
Range on HMM: 52-297/302.0
SVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKdvVP-TSPCFIATQAPLQPSL---NDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDKGAAQ
. ||...|.  .|.|.| | .. |.|.||| ..  ||  ..  | .| | . |    ..|| ||....   .|.|. .    |    .  ..|.  |. .
lkknqsedvpildsnlvkleaepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk...tlselfpkksgdyk

KFGDISVSLQSKRTTDYHVeRIIHLTHLP----TRQMRTITHLqfTAWPEFGVPSSPGVLLQFIDEVqsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYT
..|.. |  .    .. ..     .  ||       . ....|  | |..  || . . | . . .|   . .. |.. ..|.    |. | |.|  . .
eygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlav

AAREINEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAKRGVATK
|  ....|     | ..||..| ||  ..   .|  . | |.|.| .. . |  . .|
aveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkk
subfamily_CG42327_pd Subfamily CG42327 296-435 3e-22 73.7 In-house 54-192 (319) alignment 
Range on Protein: 296-435
Range on HMM: 54-192/319.0
TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGA--AQKFGDISVSLQSKRTTDYHVERII
 .| |..||...    .   .||.|..|. |  ||| .|.|||. .|| | .      |      |.|  ..    . .||| |.|. . . | ..   .
dkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlsel..GikvcaeylPtketldntslyGdilvtlkgrevkdryaistl

HLTHLPTRQMRTITHLQFtAWPEFGVPSSPGVLLQFIDEVQS
 | ..   . | .||  .  |.| .||...  |.  . ||.|
llkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 274-466 1.4e-19 64.9 In-house 43-231 (312) alignment 
Range on Protein: 274-466
Range on HMM: 43-231/312.0
YSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKdvVPTSPC-FIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKG-----STNFVSYW-PED-
.   ||.|.|  .|  |  | |  . || | |.|  . | |  |..||.||. .   || ..    .. |..| .    |        .. |..   || 
fkdlnrypniqcwdrgrftlagdenfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

KGAAQKFGDISVSLQSKrttDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIdevqsyhSQQRKTQIPIVVHCSAGIDRTGVFCLVY
.  ..   .| .  .||   |    |....    | |   . | |...||. |.| |    |...       |  .| . |.. |||||. ||| ..|. 
rvyteycteieiggksk...dkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll.......savkkdkkpviahcsagvgrtgtlalie

T
.
s
0048179 (Phosphotyrosine protein) phosphatases II 373-503 1.6e-19 65.5 In-house 14-136 (144) alignment 
Range on Protein: 373-503
Range on HMM: 14-136/144.0
GDISVSLQSKRTTDYHVERIIHLTH--LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAre
|.. ..|. ..  ....  .| ||.   |.   |........ || .|||...  ||.|.. ......       |..||||||..|||.... |     
gslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk..

ineGHGiADIPQVVKKLRLQRRWMISEKEQLKF
    .|  .. .... .| .| ...   .||.|
...klg.lsleealalvrsrrpgavpnpgqlrf
subfamily_egg_pd Subfamily egg 263-516 8.3e-19 62.4 In-house 29-274 (307) alignment 
Range on Protein: 263-516
Range on HMM: 29-274/307.0
TRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGT----RDDYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkgsTNF
   .  |..  .  | | . .   |  || |.       ||.| |  .|   |    || .||||. . .||| ||....   |||| |.  .     . 
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes....erc

VSYWPEDKGAAQKF--GDISVSLQSKRTTDYHVERIIHLTHL-PTRQMRTITHLQFtAWPEFGVPSSPGVLLQfidevqsyhsQQRKTQIPIVVHCSAGI
  |||  .  . ..  | . .       .   . |. .|  . . .. | . | |   . . .   ||  .|.          . |.   |.||..  |.
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlr..........klrnlskpvvvqdilGv

DRTGVFCLVYTAAREINEGhGI--ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHAL
 .....  . .|  ..  |  |    . . |. |||.||  ..   .  | |  .| . |  .
skaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 275-385 3e-17 57.4 In-house 48-168 (350) alignment 
Range on Protein: 275-385
Range on HMM: 48-168/350.0
SVKNRHPDIMPYDHNRVCLR------------GTRDDYINASFIKDV---VPTSPCF--IATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTN
  |||. .|.||.|.|| |.               .|||||...|     |   | |  |||||||.  ..||. .... .  .|..| |.     .   
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsd..velnlek

FVSYWPEdkgaaQKFGDISVSLQSKRTT
.  ||.|      .. || | |.||.  
cyrYWqe.....gsydditvklaskwen
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 277-516 2.1e-16 54.4 In-house 50-280 (303) alignment 
Range on Protein: 277-516
Range on HMM: 50-280/303.0
KNRHPDIMPYDHNRVCLrgTRDDYINASFIKdvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGSTNFVsyWPEDKGaAQKFGDIS
|||  |..  || .| |  .   || ||...  . .|   | || ||. .  ||| |. ||.   ...||.     |   ..|  .|...    || . |
knrfvdvicldhskvkl..sdssyihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv..fprnqd.flkfeers

VSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQ-FTAWPEFGVPSS-PGVLLQFIDEVQSYHSQQRKTQiPIVVHCSAGIDRTGVFCLVYTAAREINEG
. .   .  .      ...  .   . ... |.. . |||   .||     ... | ..||.  .  ... | |    .|  |.| |.|  ||   . . 
irvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalfetahlslhse

HGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIlcyARHAL
    |. ......|  |   . .  |. . |  .   | | |
qasldlvkclenvrngrlhavqnlsqfsvvytll...aehvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 326-511 5.7e-14 46.8 In-house 40-220 (255) alignment 
Range on Protein: 326-511
Range on HMM: 40-220/255.0
SLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSkrTTDYHVERIIHLTHLP--TRQMRTITHLQFTAWPEFGVPSSP
... |. ..  .... .|||       .|  .  ||.| .|   .|. |..|.     ..   | | ...|      .. .|..| ... |.|   |  .
tvdkfyqtivqtktevvvmlcdfae..egvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

GVLLQFIDEVqsyhsqqRKTqIPIVVHCSAGIDRTGVFCLV---YT-AAREINEGHGI-ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
  .|. .  |       |..  ..|||||.|| |.  | |.   |    | ... . .  |  .....|| .|.  | .  || ||   .| .
reilnilkvv.......rds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 398-509 6.1e-14 46.2 In-house 83-191 (440) alignment 
Range on Protein: 398-509
Range on HMM: 83-191/440.0
LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIaDIPQVVKKLRLQRRWMISE
.   . ||. . .. .||. |||   | .|..|..|.  .||..  . |..||||||  ||||   | .  || .    | ||  ... .| .|  |.  
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvn..esqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqt

KEQLKFSYDAIL
 ||  | ..|.|
peqyafvheavl
subfamily_eak_pd Subfamily eak 260-514 1.6e-13 44.8 In-house 36-307 (332) alignment 
Range on Protein: 260-514
Range on HMM: 36-307/332.0
DRETRQFSIA-IARCYSVKNRHPDIMPYDHNRVCLRGT---RDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGS
|.  |  ||   ||  .|.    .|.|||.. | |  .   |. ||||| . .       .| | .. .  .  || ||.||..  ||.|| .    .. 
ddyqrllsisetarleavnrnvvkivpydrylvrltssqlnrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve..lkl

TNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSS------------PGVLLQFIDEVQSYHSQQRK-
 ..  |.|..     ||| . |  ..    .    | . |.     .   . | ..  | |. .|               ||||    . . ..|  .| 
eksdkyfpdktreelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkky

-----TQIPIvVHCSAGIDRTGVFCLVYTAAREINE-GHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
     .  || . .. |  |.||| ..    | |..  .    . ... | . .|   .  . |  | |...| | ..
ihtppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 322-522 1.8e-13 44.6 In-house 99-295 (302) alignment 
Range on Protein: 322-522
Range on HMM: 99-295/302.0
PLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGAAQKFGDISVSLQS-----KRTTDYHVERI----IHLTHLPTRQMRTITHLQFT
| . .|. .| .. . . .|.| | |     ..   . .|. .. |   |||  .|   |     .. || .  ..    |. ..  ... .|.  |.|.
pkkstlekhwalieqynvaivvqlcs..fvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPEFGVPSSPGVLLQFIDEVQSYhsqqrKTQipIVVHCSAGIDRTGVFCLVYTaAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFsydAILCYA
|||. | |  .   |. .   .||     |..  ..||||||. ||| .  .     ..   . ..|. ..|. .|  |   . ...|| .    .|| .
awpdhGapkeaytaldilkfcesy.....kkn..vlvhcsaGvGrtGtlvaiky.GiqlcskkkvtdllsivlpvrqcryGavqdeqqliy...lllcvt

RHALAKRGVA
.  ..| || 
kglmekagvl
subfamily_CG42327_pd Subfamily CG42327 435-513 5.3e-13 43.3 In-house 238-316 (319) alignment 
Range on Protein: 435-513
Range on HMM: 238-316/319.0
SYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
| .| .|. | |.||||| |. |||.      | |...| .   ||||.|  .| .|   . .||| .| |  .  ||.
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_hpo-7_pd Subfamily hpo-7 326-522 5.3e-12 40.2 In-house 46-237 (263) alignment 
Range on Protein: 326-522
Range on HMM: 46-237/263.0
SLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTtdYHVERIIHLTH-LP-TRQMRTITHLQFTAWPEFGVPSSP
 .. |. ..  .... .|||       .|  .  ||.| .|   ||. ...|.          . . ..|.  |   ....|..| ... |.|   |  .
tidkfyqtivqtktevvvmLcDfne..egvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

GVLLQFIDEVQSYhsqqRktqiPIVVHCSAGIDRTGVFCL---VYT-AAREINEGHGI-ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAK
   |. .. ..      .    ..|||||.|| |.  | .   ||    | ... . .  |  .....|| .|.  | .  || ||   .| .  .. ||
reilnilkvarns....k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfak

RGVA
  . 
gele
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 405-513 8.8e-12 39.4 In-house 216-345 (350) alignment 
Range on Protein: 405-513
Range on HMM: 216-345/350.0
TITHLQFTAWPEFGVPSSPGVLLQFID-------EVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYT-------------AAREINEGHGIAD-IPQV
 . .||.  |.. ..   |  .|| ..       .  .    . . . ||.||||||. |||... .                 |...    . | | ..
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKKLRLQRRWMISEKEQLKFSYDAILCYAR
|..|| ||  |. ...|  | |.|.| | .
vnelrkqrismvqnldqfifiYeallfyfa
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 270-382 1.1e-10 35.5 In-house 92-198 (244) alignment 
Range on Protein: 270-382
Range on HMM: 92-198/244.0
IARCYSVKNRHPDIMPYDHNRVCLRG--TRDDYINASFIKDVVPTSpCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpatgkgsTNFVSYWPEDKG
.    | |||.   .|.| ||| |      . ||||||.  .  |.  .| || ||  .  ||| |. |.   ..|.| |         .   |||. . 
fnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrta.eyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.......eeedeywpdsep

AAQKFGDISVSLQSK
      ||.|.|  .
lewyeeditvtltdr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 434-510 2.6e-10 34.7 In-house 219-293 (297) alignment 
Range on Protein: 434-510
Range on HMM: 219-293/297.0
QSYHSQQRkTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
.|.....   .....||||||. |.||  |  . .  .  .. | |.  ....|| ||  ..   || .. |||.| 
eslraemp.rnayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 284-418 6.5e-09 30.2 In-house 3-125 (130) alignment 
Range on Protein: 284-418
Range on HMM: 3-125/130.0
MPYDHNRVClrgtRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpatgkgsTNFVSYWPEDKGAAQKFGDISVSLQSKR
.... .|.      ..||||||.  .   .  .. ||.||  .  ||| |. |.   ..|.| |         .   |||. .       || |.|  . 
lefevsrlq....gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.......eeedeywpdsePlewyeediivtltdrd

TTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFG
  ..     ..  .   .  ...| .| . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg
0038934 (Phosphotyrosine protein) phosphatases II 412-466 3.6e-08 28.8 In-house 85-137 (194) alignment 
Range on Protein: 412-466
Range on HMM: 85-137/194.0
TAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTqiPIVVHCSAGIDRTGVFCLVYT
  .|..|.. |  .||.|.| |. ..... .    ..||| ||. |||...  | 
lpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYL
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 275-365 1.6e-07 25.0 In-house 49-156 (349) alignment 
Range on Protein: 275-365
Range on HMM: 49-156/349.0
SVKNRHPDIMPYDHNRVCLR------------------GTRDDYINASFIKD-VVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgs
  |||. ||.||.| || |.                  |  |||||| ..|   . .   .|||||||  ...||. ..  ..  ... | .  ...   
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl..

TNFVSYWPED
  .  || | 
ekcdiywqel
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 275-320 3.7e-07 24.2 In-house 49-94 (95) alignment 
Range on Protein: 275-320
Range on HMM: 49-94/95.0
SVKNRHPDIMPYDHNRVCLRGTRD-DYINASFIkDVVPTSPCFIATQ
  |||  .|.|||  ||.|   || ||||| |. |      |.||.|
ipknrflnifpydatrvvlttkrdsdyinacfv.dgyarkncyiaaq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 406-511 5e-07 23.4 In-house 220-343 (349) alignment 
Range on Protein: 406-511
Range on HMM: 220-343/349.0
ITHLQFTAWPEFGVPSSPGVLLQ-------FIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAR-------EIN---EGHGIA-DIPQVVKKL
.  ||.  |.. ..   |  .||       .||.  .    . .   ...||||||  ||||.. .            | |           |  .| .|
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnel

RLQRRWMISEKEQLKFSYDAILCY
| ||  |. .  |  . |.|.| |
rkqrismvqnlaqfiaiyealLky
PTPc_motif_SM00404 426-466 9.1e-07 23.9 In-house 62-102 (140) alignment 
Range on Protein: 426-466
Range on HMM: 62-102/140.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYT
|....|.| .. .. .|..  ..||| ||. |.. ....| 
lskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl
Y_phosphatase3 Tyrosine phosphatase family 437-473 2.4e-06 22.6 Pfam-A 117-153 (164) alignment 
Range on Protein: 437-473
Range on HMM: 117-153/164.0
HSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINE
 .. .... |...||.|| |||||.. .  .. ...|
lealaeeegpvlfHCtaGKDRTGvvaalllsllgvde
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 278-344 4.7e-06 20.3 In-house 38-106 (332) alignment 
Range on Protein: 278-344
Range on HMM: 38-106/332.0
NRHPDIMPYDHNRVCLR--GTRDDYINASFIKDVVPTSpCFIATQAPLQPSLN-DFWLMVYEQQASIIVM
|| | .  .||.|| |     .||. |||..      | ..| .|||..   .  || || |.. |.|..
nriphlycfdhsrvelapqdgkddfynaswvdgyskks.ayifaqapfndhteyvfwrmvserkpsmilv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 296-346 5.6e-06 20.1 In-house 68-117 (347) alignment 
Range on Protein: 296-346
Range on HMM: 68-117/347.0
TRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
  . ||||| ||    .|  .| || ||  .. ||| ||.  . . .| ..
dvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
DSPc Dual specificity phosphatase, catalytic domain 426-465 7.4e-06 20.9 Pfam-A 55-94 (133) alignment 
Range on Protein: 426-465
Range on HMM: 55-94/133.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVY
. ....|. .. .. .. .  ..||| ||| |.. ....|
iskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY
DSPc Dual specificity phosphatase, catalytic domain 426-465 7.4e-06 20.9 In-house 55-94 (133) alignment 
Range on Protein: 426-465
Range on HMM: 55-94/133.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVY
. ....|. .. .. .. .  ..||| ||| |.. ....|
iskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY
0048567 (Phosphotyrosine protein) phosphatases II 412-465 7.6e-06 20.4 In-house 43-98 (157) alignment 
Range on Protein: 412-465
Range on HMM: 43-98/157.0
TAWPEFGvPSSPGVLLQFIDEVQSYHSQQRKTQIPIVVHCSAGI---DRTGVFCLVY
. . .|| | . ..| .||  . .. .. ...  .|.|||.||     ||....  |
dfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcY