Gene PTPN3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP061_AA protein Get Run
SpurP061_AA_368-647 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN3_pd Subfamily PTPN3 370-651 2.3e-147 484.3 In-house 1-280 (280) alignment
Range on Protein: 370-651
Range on HMM: 1-280/280.0
LTESFMLLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTgDYINANTINMDIPGFDLVNKYVAAQGPLPNTVND
|.||..||.|||..|. .|||.||||||||... |.|..||..|||||||.|||||||.|.|..| ||||||..||.||. .|||.|.|.||||..|..|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatd

FWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL
||.|||||.|.|||||||.|||||||||.|||. .|.|..| ...|.|...||| |...|........||||| .||.||.|||||||||||.|||.|| 
fWqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefve

RVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDCIV
|||..| |.. |..||||||||||||||..|||..||||.||||||||||| |||| ||.|||.|||||||||..||....|
rvrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeilv

0050432 (Phosphotyrosine protein) phosphatases II 366-648 2.5e-91 301.5 In-house 24-301 (308) alignment
Range on Protein: 366-648
Range on HMM: 24-301/308.0
EIDSLTESFMLLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILreADTGDYINANTINMDIpgFDLVNKYVAAQGPLPN
.  |. .   ||.. ||.|.  ..| .|...|| ... ...| ||. ||||.|| ||| .||.|   .. |||||. ... .  ..| .|..|.||||||
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys..sklprkfIatqgPlpn

TVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDL--DDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSD
||.||| |||||....|||||. ||.||.||..|||.   .. |..| .. |....... ... .| ....|. ..|.|.| ...| .|||||||.. ..
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg.kftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

FLDFVLRVRQCRvgMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
.|||. .||...   . |..||||||.||||..|.........|..  | ....|.. | |||. .||  ||.|...|..  ...
lldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0051299 (Phosphotyrosine protein) phosphatases II 382-644 2.6e-88 291.5 In-house 21-284 (288) alignment
Range on Protein: 382-644
Range on HMM: 21-284/288.0
DTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQR
.. . ...|..|....| .|. |..| ||. ||||.|| ||| .||.|.  |    .|||||. |    .|..| .|..|.||||||||.||| |||||.
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqn

STLIVMLTTNVERGRVKCHKYWPDlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNT----ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC
...|||||. ||.||.||..|||. .. |..|. . |....... ... .| ... |.     ..|.|.| ...| .||||||||. ...|||. .||..
vrvIvmltklvelgrekcaqYwpl.ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

RVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
.   . |..||||||.||||..|.........|... | .|..|.. | |||...||  ||.||.||.. 
lasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0036941 (Phosphotyrosine protein) phosphatases II 378-653 2.8e-85 281.5 In-house 7-284 (297) alignment
Range on Protein: 378-653
Range on HMM: 7-284/297.0
QEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILrEADTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQ
 . |.. .   .|..|.. .. ... . .| ||. ||||.|| ||| |||.| . .  |||||. .    .|.|| .|..|.||||||||.||| |||||
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweq

RSTLIVMLTTNVERGRVKCHKYWPDL-DDRLKFgPDLEVRCTRCDE--TPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC
..| |||||. ||.||.||..|||.  .. |..  |. |.......   ... .| . . .| ..|.|.| ...|  |||||||.. ...|||. .||..
nvtvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

RVG--MDVPTIVHCSAGIGRTGVLITMETAMCLIE---ANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDCIVKP
.     . |..||||||.||.|..|.........|    .. | .|..|.. |.|||. .||  ||.|..||..  ..   .|.
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke

subfamily_PTPRD_pd Subfamily PTPRD 395-655 1.1e-84 280.1 In-house 33-289 (564) alignment
Range on Protein: 395-655
Range on HMM: 33-289/564.0
RKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVER
.... .|. |..  .| ||||| .| .||..||.|..    .  |||||. |.    |..  ..|.|.||||..|..||| |||||.|. |||||  .|.
eegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk

GRVKCHKYWPDLDdRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIG
|.||||||||. . . ..| .|.|  . . |   .  |.|.. .. ..| | | | ....|||||||.   ..||.. .||...     |..||||||.|
gkvkchkYWPekg.tetyg.eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVG

RTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDCIVKPID
|||. |...  .  |.... |    .|.. | ||....||  || |. |||   ...| .. ..
RTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile.alacgnteve

0047943 (Phosphotyrosine protein) phosphatases II 377-643 1.9e-84 278.6 In-house 5-269 (273) alignment
Range on Protein: 377-643
Range on HMM: 5-269/273.0
LQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILrEADTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWE
|.. |.... ...|..|.. || .|. ...| ||  ||||.|| ||| .||.| . .. |||||. .    .|..| .|..|.||||||||.||| ||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvwe

QRSTLIVMLTTNVERGRVKCHKYWPDLDDR-LKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCR
|....|||||. ||.||.||..|||.  .   .   .. |....... ...  | ... |. |.|.|.| ...|  |||||||.. ...|.|.  ||...
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

VG--MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
     . |..||||||.||||..|.........|..  | .|..|.  |.|||. .||  ||.|..||..
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

0046845 (Phosphotyrosine protein) phosphatases II 388-647 2.2e-84 278.5 In-house 4-275 (284) alignment
Range on Protein: 388-647
Range on HMM: 4-275/284.0
AQFDQLYRKKPGM--TMGACRLAENVAKNRYRDIAPYDATRVILREADT----GDYINANTINMD-IPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRST
..| .|.. .. .  .. ...| ||. ||||.|| ||| .||.|.  |     .|||||. ...  .. ..  .|..|.||||||||.||| |||||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

LIVMLTTNVERGRVKCHKYWPDLDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTA-TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV--G
.|||||. ||.||.||..|||. .. |..|. . |....... ... .| . . |.  |.|.|.| ...| .|||||||....|.|.|.  ||...   .
vIVmltelvengrekcaqYwplegevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

MDVPTIVHCSAGIGRTGVLITMETAMCLIEANE---PVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 . |..||||||.||||..|.........|...    | .|..|.  |.|||. .|| .||.||.||..  ..
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0040438 (Phosphotyrosine protein) phosphatases II 384-649 2.6e-83 275.2 In-house 18-279 (317) alignment
Range on Protein: 384-649
Range on HMM: 18-279/317.0
GMAIAQFDQLYRKKPGmTMGACRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRST
..   .| .|.. |.  |.   .| ||  ||||.|| |||..||.|   .     |||||. .    .|..| .|..|.||||||||.||| |||||..|
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvt

LIVMLTTNVERGRVKCHKYWPDlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDV
.|||||. .|.||.||..|||. .. |..|. . |... ..| ... .| . . .. ..|.|.| ...| .|||||||.. ...|||. .||... . . 
vivmLteleelgrekcaqYwpl.getltygd.ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpgg

PTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDC
|..||||||.||||..|.........| .. | . ..|.. | |||. .|| .||.|...|..  ..  
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0045450 (Phosphotyrosine protein) phosphatases II 388-646 3.6e-81 268.5 In-house 31-304 (307) alignment
Range on Protein: 388-646
Range on HMM: 31-304/307.0
AQFDQLYRKKP--GMTMGACRLAENVAKNRYRDIAPYDATRVILREAD----TGDYINANTINMDI----PGFDLVNKYVAAQGPLPNTVNDFWYMVWEQ
..| .|.. ..   ... . .| ||  ||||.|| ||| |||.|   |    ..|||||. .....    .|.|| .|..|.|||||.||.||| |.|||
kefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq

RSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNT-ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV
..|.|||||. ||.||.||..|||| .. | .|. . |.... .. ... .| . . ..  |.|.|.| ...| .|||||||.. ...|||. .||... 
gvtvivmltelvelgrekcaqywPdegeeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

G--MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEP---VYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
    . |..||||||.||||..|.. ......|...    | .|..|.. |.|||  .|.  ||.|..||..  .
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPN13_pd Subfamily PTPN13 376-645 1.4e-80 265.5 In-house 3-268 (273) alignment
Range on Protein: 376-645
Range on HMM: 3-268/273.0
LLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTgdYINANTINMDIpGFDlVNKYVAAQGPLPNTVNDFWYMVW
 ||. || ..   .|..|   ||  |    . .|| .|||||.. |||.|||.| .  .  ||||. |.. . | |   .|.|.|||||.||.||| |||
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv.gkd.eyeyiacqGPlPetvkdfwqmvw

EQRSTLIVMLTTNVERGRVKCHKYWPDLD-DRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC
||....|.|.|...|.|.||||.|||.   ..||    |||.  .  .  .|. |.. . .....| | | ....|.|||||||  . ..| || .||. 
eqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

RVgMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
.     | .|||||||||.|.|||..... ||| ....   .|||. |.||  ..||  || || .||. |
qt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

0043336 (Phosphotyrosine protein) phosphatases II 383-643 3.5e-80 264.7 In-house 19-274 (278) alignment
Range on Protein: 383-643
Range on HMM: 19-274/278.0
TGMAIAQFDQLYRKKPgMTMGACRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRS
  . ...| .|.. |. .|.  ..| ||. ||||.|| ||| .||.|   .     |||||...    .|..  .|..|.|||||.||.||| ||||...
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgv

TLIVMLTTNVERGRVKCHKYWPdlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD
| |||||. ||.|||||..|||  .. |..|. . |....... . .  |.. . |. ..|.|.|....|..|||||||.. |..|||. .||...   .
ttivmLtelvelgrvkcaqYwp..ggsltygd.ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsn

VPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 |..||||||.||||..|.........| .  | ....|.. | |||. .||  ||.|..||..
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

DSPc_SM00195 389-646 4.8e-80 264.0 In-house 5-262 (263) alignment
Range on Protein: 389-646
Range on HMM: 5-262/263.0
QFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
.|..| ....  ..   .  .|..||||..| ||| |||.| . .   . |||||| |...    .  .||.|.|||||.||.||| ||||.....||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTNVERGRVKCHKYWPDL-DDRLKFGpDLEVRCTRCDETP-SFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTI
| ..|.|. ||..|||.  ..  .|| ...| ........ ..  |.. . .....|.| | |.|| .||||||||. ...|...  |....   ..|..
teeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||||||.||||...|.....  .|... |   .||.  |.|||...|| .||.|..|||....
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 389-646 4.8e-80 264.0 In-house 5-262 (263) alignment
Range on Protein: 389-646
Range on HMM: 5-262/263.0
QFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
.|..| ....  ..   .  .|..||||..| ||| |||.| . .   . |||||| |...    .  .||.|.|||||.||.||| ||||.....||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTNVERGRVKCHKYWPDL-DDRLKFGpDLEVRCTRCDETP-SFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTI
| ..|.|. ||..|||.  ..  .|| ...| ........ ..  |.. . .....|.| | |.|| .||||||||. ...|...  |....   ..|..
teeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||||||.||||...|.....  .|... |   .||.  |.|||...|| .||.|..|||....
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRB_pd Subfamily PTPRB 388-646 3.3e-79 261.0 In-house 29-285 (293) alignment
Range on Protein: 388-646
Range on HMM: 29-285/293.0
AQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
 ....|   .  ... | .||.| |||||..| |||..|| |   .. .. ||||||     |||.   ....|.|||||.||.||| ||||..|. |||
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCR--VGMDVPT
||  ||.|.|||..|||. ..   .| |..|  .  .|.  .. |.. |..  .|||| | |.....|||||||.... .|||| .||.       . |.
ltqlvekgkvkCeeYWPadeepvlyG.dikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPi

IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
.||||||.||||..|.... .  || .. |  . ||   | .| .|.|| .|| |. ...... 
vvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

0039614 (Phosphotyrosine protein) phosphatases II 375-645 3.6e-78 258.3 In-house 23-288 (297) alignment
Range on Protein: 375-645
Range on HMM: 23-288/297.0
MLLQEGLDTGMAIAQFDQLYRKKPGmtMGACRLAENVAKNRYRDIAPYDATRVILREADT----GDYINANTInmdiPGFDL-VNKYVAAQGPLPNTVND
 ||   ..... ...| .|.. ||   .  ..| ||. ||||.|| ||| .||.|   |      |||||. .    .|.||  .|..|.|||||.||.|
lllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetved

FWYMVWEQRSTLIVMLTTNVERGRvKCHKYWPDLDDrlKFGPdLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL
|| |||||..| |||||. ||.|| ||..|||.  .  ..|. . |....... . . .| . . |  ..|.|.| ..||. |||||||......|.|. 
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygd.ftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

RVRQCRVG--MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
 ||...     . |..||||||.||||..|.. ......| .  | .|..|.. | |||. .||  ||.|...|..  
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 387-646 1.3e-76 252.4 In-house 18-276 (281) alignment
Range on Protein: 387-646
Range on HMM: 18-276/281.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
| ....|.    . |  | .  ||| ||||..|  |||||| .    |. . |||||| .    ||..  ..|.|.|||.|.....|| |||||. ..||
ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv....pgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIIcNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVPT
|.| ..| |..|||.|||| . .||.| |. |. |.  |..... | | . .. . |.| | |..|.||||||||......|.|   |....    ..| 
mvtreieagklkChrYWPddnselkyg.dvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkapl

IVHCSAGIGRTGVLITMETAMCLIEAN-EPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
..|||||.||||. |......  .||. |.. . ..|.  | .| ...|| .||.||  |.... 
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0045098 (Phosphotyrosine protein) phosphatases II 387-646 6.5e-75 247.4 In-house 10-272 (278) alignment
Range on Protein: 387-646
Range on HMM: 10-272/278.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIlreadtgDYINANTINMDiPgfdlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLT
  .|..|..  .  ..    . .|..||||.|| ||| .||.       |||||. |..  |     .|..|.|||||.||.||| |.||...| |||||
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivmlt

TNVERGRVKCHKYWPDlDDRLKFgPDLEVRCTRCDETPSFAYRDFIICNT----ATKEERIVLQMQYVAWPDHGVPDDS--SDFLDFVLRVRQCRV----
. ||.||.||..|||. .. | .  |..|... ..... . .|.....|.    .. |.| | ...|. |||||||...  . ||... ..|...     
elvelgrekcaqywpe.ggslty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------GMDVPTIVHCSAGIGRTGVLITMETAMCLIeaNEPVYPLDIVRTERDQRPM-LIQTAAQYKFVCEAIIRVY
         . . |..||||||.||||.|. . . ..|.  .. | .|..|.. | |||.  .|.  ||.|..|......
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

Y_phosphatase Protein-tyrosine phosphatase 410-643 2.2e-74 245.2 Pfam-A 1-234 (235) alignment
Range on Protein: 410-643
Range on HMM: 1-234/235.0
NVAKNRYRDIAPYDATRVIL-READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRL
|  ||||.|| ||| ||| |  . .. ||||||..     |..  .|..|.||||..|..||| |||......|||||...|.||.||..||| . .. |
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KFGPdLEVRCT--RCDETPSFAYRDFIICNTATK-EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMC
..|  ..|...   .... ... |.. . ..... |.|.| |..| .|||||||......||.. .|.. .   . |..||||||.||||..........
tygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 .||.| |  |.||.. | |||...|...||.|...||.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 410-643 2.2e-74 245.2 In-house 1-234 (235) alignment
Range on Protein: 410-643
Range on HMM: 1-234/235.0
NVAKNRYRDIAPYDATRVIL-READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRL
|  ||||.|| ||| ||| |  . .. ||||||..     |..  .|..|.||||..|..||| |||......|||||...|.||.||..||| . .. |
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KFGPdLEVRCT--RCDETPSFAYRDFIICNTATK-EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMC
..|  ..|...   .... ... |.. . ..... |.|.| |..| .|||||||......||.. .|.. .   . |..||||||.||||..........
tygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 .||.| |  |.||.. | |||...|...||.|...||.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_PTPN6_pd Subfamily PTPN6 390-647 7e-74 243.6 In-house 32-297 (306) alignment
Range on Protein: 390-647
Range on HMM: 32-297/306.0
FDQLYRK--KPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADT-G-DYINANTINMDIPGFDlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
|..| ..  |  ..    . .||  ||||. | |.| |||||.| .. | |||||| |. ...| |  ..|.|.|| |..||.||| |||.. |..|||.
feelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivmt

TTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD----V
|..||||. || .||||  .. ..| ...|.... ... .. .|.. ... .  |||| | |... .||||||| | . .|||.  |.. .  .      
tkevErgkekCarYWPdeeekeeyG.kisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDI---VRTERDQRPMLIQTAAQYKFVCEAIiRVYM
|..||||||||||| .| ... . ||| .   ...||   |.. |.||  |.||..||||| .|| . |.
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyi

0042113 (Phosphotyrosine protein) phosphatases II 405-643 3.4e-73 241.4 In-house 4-240 (245) alignment
Range on Protein: 405-643
Range on HMM: 4-240/245.0
CRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP
..| ||. ||||.|| ||| |||.| . ..    |||||. .    .|..  .|. |.|||||.||.||| |.||...| |||||. .|.|||||..|||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

DlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVPTIVHCSAGIGRTGVLITME
. .. |..|  . |......  ...  | . . |. ..|.| |....|. ||||||||.....|||. .||...  . . |..||||||.||||..|.. 
l.gesltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

TAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
......|..  | . ..|.  |.|||. .||  ||.|. ||..
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 376-650 3.7e-73 241.4 In-house 13-283 (318) alignment
Range on Protein: 376-650
Range on HMM: 13-283/318.0
LLQEGLDTGMAiAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWY
 |.|  .. .  .....| |..  .|        | ||||| .| .|| ||| |..     . |||||| |    .|.   ..|.|||.|||.|..||| 
rlresGellls.eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi....dGyrrkkayiaaqaPlpetieDfWr

MVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDrLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVR
||||| |..|||||  .|||..|.|.|||. .   ..| .| |  .   |. ..  | | . .| ..|.|.| | .| .|||.|||......||.| .|.
mvWeqnsavivmltqeeergkakvhryWPskgs.rsyg.klvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

QCRV-GMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDCI
.        |..||||||.||||| |.... .  |.|.. |  ...|.. |.||....||  ||.|. ....  .. . 
kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle.alasg

0040439 (Phosphotyrosine protein) phosphatases II 404-645 2.3e-72 238.9 In-house 5-245 (249) alignment
Range on Protein: 404-645
Range on HMM: 5-245/249.0
ACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
 ..| ||. ||||.|| ||| .||.|   ..   .|||||. |    .|..  ....|.|||||.||.||| |.||...| |||||. ||.||.||..||
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV--GMDVPTIVHCSAGIGRTGVLIT
|. .. |..|  . |....... ...  | . . |. ..|.| ||..||. |||||||.. .|.|||. .||...   . . |..||||||.||||..|.
pl.ggsleygd.ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

METAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
. ......| .  | ....|.. |.|||. .|.  ||.|..||... 
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 401-646 1.7e-69 229.1 In-house 38-279 (288) alignment
Range on Protein: 401-646
Range on HMM: 38-279/288.0
TMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCH
.  | |||.|  |||||.| ||| .|| |..    .. |||||. |. .    .  .||.|.||||..|||||| .|.|.... |||||  ||.|. ||.
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

KYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICntATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLI
.|||| |.  ..| ...|  .   |. .|  | ...    .|.|. . |.|| ||||||||... ..|...  | .       | |||||||.||||. |
eYWPdadkpknyG.svtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFi

TMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
......  .|... .  ...|   | ||..|.||  || |. |... . 
aldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_PTPN14_pd Subfamily PTPN14 374-644 2.4e-68 225.4 In-house 13-294 (300) alignment
Range on Protein: 374-644
Range on HMM: 13-294/300.0
FMLLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA--DTGDYINANTINMDIPGFDlvNKYVAAQGPLPNTVNDFW
.  |.. |. |.  ...... .|.   .. ...| ||. |||..|. ||. .|| |  .  .. .|||| .|.. . | .   .|..|||||..||.|||
akilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggke..rsyivaqgPleltvqdfW

YMVWEQRSTLIVMLTTNVERGRVKCHKYWPDL---DDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFV
 |||||  .|||||| . | |. |..||.|.|    ....||   .|     ....|.. . . .    .|||| |. .||. |||||||.| ..||...
qmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgk.fkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyL

LRVRQCRVGM---------DVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .|.  |  .         . | .||||||.|||||||. .  .  .| || .    .... | || .|.|| |||||| ...|.
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPN12_pd Subfamily PTPN12 387-647 6.7e-68 223.7 In-house 17-278 (290) alignment
Range on Protein: 387-647
Range on HMM: 17-278/290.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
. .  . |...  ..  | .  |||.||||.|| ||| .|| |..    .  |||||| |.    | .   .|.|||||||.|..||| |.||.. ...|
lkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfik....gvegkleyiaaqgPLpktlddfWrmiweknveivv

MLTTNVERGRVKCHKYWPDL-DDRLKFGpDLEVRCTRCDETP-SFAYRDFIIcnTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVP
|.  .|| |. ||..|||.  ...|.|| ..|| ... . .   |  | . .  .| ||.|.| |..| ||||||||   .. |...  ||. .   |.|
maCrevelgkkkCerYWpeegeeelefg.efevtleeekavdddflirtLkv..eaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaP

TIVHCSAGIGRTGVLITMETAMCLIEANEP---VYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 .||||||.||||..|... .  |..|.     .   |.|.. | ||. |.||  ||..| .|.. .  
lvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

0037934 (Phosphotyrosine protein) phosphatases II 405-643 1.6e-67 222.9 In-house 5-239 (243) alignment
Range on Protein: 405-643
Range on HMM: 5-239/243.0
CRLAENVAKNRYRDIAPYDATRVILreaDTGDYINANTINMDiPgfdlvnKYVAAQGPLPNTVND----FWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
..| ||. ||||.|| ||| .||.|   . .|||||| |..  |      .. | |||||.||.|    || |.||...| |||||. ||.||.||..||
allpenlsknrysdilpydhsrvkl...egsdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdlDDRlKFGPdLEVRCTRCDETPSFAYRDFIICNTA-TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC--------RVGMDVPTIVHCSAGIG
|  ..   .|. ..|... . ..... .| . ..|.  ....| | . .|..||||||||. .|.|||.  ||..            . |..||||||.|
p..gev.tygd.ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGVLITMETAMCLIeanePVYPLDIVRTERDQRPM-LIQTAAQYKFVCEAII
|||.||.. . . |.     | ....|.. |.|||.  .||  ||.|. ||..
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Ptp69D_pd Subfamily Ptp69D 367-647 5.3e-66 217.8 In-house 6-287 (307) alignment
Range on Protein: 367-647
Range on HMM: 6-287/307.0
IDSLTESFMLLQEGLDTGMAIaQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPL
||.|.|..   ..  | |.|   ...| ...   .  .    ||  |||| || ..| |||.|..    .. |||||. |.    |..  .|..|||.|.
iddleealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPv

PNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTA-----TKEERIVLQMQYVAWPDHGVP
 .|..||| |..|| .||||||.   |  | ||.||||. .|  ..| |. |.. . .... .. |.. . ..       ...| |.| .| .|.|  ||
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi.edevqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

DDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
. .   |... .||.       | .|||||| ||.|......  .  ..|.. |   ..|.  | ||..|.|  .||.|.  |..   .
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 367-644 1.2e-65 216.6 In-house 7-281 (319) alignment
Range on Protein: 367-644
Range on HMM: 7-281/319.0
IDSLTESFMLLQEGLDTGMAiAQFDQLYRKKPGmTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPL
.. | | .. |..  .|...  .| .|   ..  |.  .   ||  ||||..| .|| |||.| | |     |||||. |.    |..  .|..|.|.||
vqeLkerlkalastgetlle.kefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPl

PNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDdRLKFGpDLEVRCTRCDETPSFAYRDFIIcNTATKEE--RIVLQMQYVAWPDHGVPDDS
 ||..||| ||||..|  .||||  ||...||..||||. .   ..|  | |     .|.  .  |.. . |... |   | | . || .||||.||...
entiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyG.rlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPeka

SDFLDFVLRVRQCRVG-MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
   ||.. |.|. | .  . | .||||||.||||  |... ..  .. .. .    .|.. | ||....|. .||||. ||.. 
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle

subfamily_PTPRA_pd Subfamily PTPRA 398-647 7e-65 214.1 In-house 46-296 (330) alignment
Range on Protein: 398-647
Range on HMM: 46-296/330.0
PGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRV
   |. ..   ||  |||. .| ||| .|||| .    .. |||||  |.    |.   .|..|||||. .||.||| |.|||.|. |||||   || . 
iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkee

KCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIIC----NTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGI
||..|||| .  . .| .. |    . .. ... |.|..     .|  |..|.| |. . .||| ||| ..   |... .|....  .  | .||||||.
kcaqywPd.eGlvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGv

GRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
|||| .|.... .  ..|.. |   ..|.  | ||| ..||  ||.|. ...   |.
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

subfamily_PTPN1_pd Subfamily PTPN1 401-644 3.2e-64 211.4 In-house 23-269 (290) alignment
Range on Protein: 401-644
Range on HMM: 23-269/290.0
TMGACRLAENVAKNRYRDIAPYDATRVILREADTgDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
.. ...| || ..|||||. ||| .|..|..||. |||||. ....    ..  .|. .||||||||. || |||||.|  .|||   ||....||..||
ptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvele....eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PDLDD--RLKFG-PDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVG-M-DVPTIVHCSAGIGRTGV
|  ..   |..    |.|.  . ...  .  | . . |  |.| | .|.. |..||| |||.  . ||.|. .||.. .      |...||||||||.| 
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

LITMETAMCLIEANEPVYPLDIVR---TERDQRPMLIQTAAQYKFVCEAIIR
.. ..| . |||... .  .|| .     | .|  ||||| | .|   ||. 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPN9_pd Subfamily PTPN9 388-644 4.4e-63 208.1 In-house 20-288 (297) alignment
Range on Protein: 388-644
Range on HMM: 20-288/297.0
AQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
 .. .. ....  |. | .|  |. |||| |.  || ||| | .    .. |||||| ..    |.   . ..|.||||..||.||| |||||.   |||
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd....GykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LTTNVERGRVKCHKYWP-DLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV------G
 |  |||||.|| .||| . ... .|| ||.|.    .|.  .  | . | |. |.|.| |   |...|||.|||......||..  ||. .       |
ttrvvergrlkcgqyWpleeessaefg.dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

-------MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
        . | .||||||||||| .||.. ..  .|  . |   . |.. | ||   |||  ||.|   |.. 
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 388-644 4.8e-63 208.1 In-house 26-281 (305) alignment
Range on Protein: 388-644
Range on HMM: 26-281/305.0
AQFDQLYRKKPGMTMGacRLAENVAKNRYRDIAPYDATRVILREADTGD---YINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
||...||...  . .|  .  .|.||||...| ..|  |.||.| .. |   ||||. ..    |..  .||..|||||.|||.|||....| . . |||
aqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstivm

LTTNVERGRVKCHKYWPDLDDR-LKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVP
||  || |. ||..|||.   .  .|| ...|  .   ... .  |.. |..    ||.| |||.|   |||||||. .. .|... ||.. .  . .||
ltklveggkdkCrqYWpesktekkefg.efsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

TIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .||||||.||||| |... |.  ... | |   ..... | .|. ..|| .|| |. .|.  
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde

subfamily_PTPRK_pd Subfamily PTPRK 404-644 1.7e-62 206.1 In-house 37-275 (314) alignment
Range on Protein: 404-644
Range on HMM: 37-275/314.0
ACRLAENVAKNRYRDIAPYDATRVILREADTG---DYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
|..  || .|||. || .|| .||.|   |     |||||. |     ..   ......||||..||.||| .|...... |||||  || ||||| |||
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PDLDDRlkFGpDLEVRCTRCDETPSFAYRDFIICN--TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLIT
|.  .   .| |..| . ...    .  | | ...   . .| |.| |.|...||||.||     .|..| || . .   . ...|||||| ||||. |.
Pedtev..yg.dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

METAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
... . .|| .. |    .|.| |.... ...|  ||||. ..|. 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_PTPN23_pd Subfamily PTPN23 409-644 4.3e-62 204.5 In-house 42-278 (288) alignment
Range on Protein: 409-644
Range on HMM: 42-278/288.0
ENVAKNRYRDIAPYDATRVILReADTGDYINANTINMDIPGfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLK
 .. |||.||| ||| .|| ||   . |||||  ..   ||     ...|.|.||..|.|||| ||.||.| .||||... |.|. |...|||   .. .
lyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspg...cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

FGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQ----CRVGMDVPTIVHCSAGIGRTGVLITMETAMC
  .||.| . .  ||. .  |....    ... . |  .|. .||..|||.  ...|.|.  |..     .  ...| .||||||.|||||.  . .|. 
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

LIEANEPVYP-LDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .|... .   ...|.. | ||   .|. .|.||. ||...
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 399-649 4.9e-62 204.9 In-house 45-292 (298) alignment
Range on Protein: 399-649
Range on HMM: 45-292/298.0
GMTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK
  .. . |  ||  |||| || ..| .||.|..    . .|||||  ..    ...  | ..|.|.||..||.||| ||.|. .. |||||. .| ...|
eeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CHKYWPDLDDRlKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD-VPTIVHCSAGIGRTG
.||||||   . ..| ...|.  . .|   .. | ... .. ...|| | |.... |||.|||  ..  ||.. .||. .     .| ||.||||.||.|
yhkywPdegke.tyg.eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsG

VLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDC
  | ... .  ..... |  ...|.. | .|| ..|| .||.|. ||... ..|.
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle.alds

subfamily_PTPRG_pd Subfamily PTPRG 397-644 5.8e-60 198.1 In-house 34-285 (563) alignment
Range on Protein: 397-644
Range on HMM: 34-285/563.0
KPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADT----GDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERG
.  ... . .  ||  |||| .| .|| .|| |..        |||||| |.    |.   ....|.||||..|..||| |.|||....|||.|  ||||
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlverg

RVKCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTAT---K---EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHC
| ||. |||  |. ...|  |.|. .. . . . . | ..| |.     |   .|. | | .|  |||||||. |   | || .  . .     |..|||
rrkcdvYWPk.desetyg.alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc

SAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
|||.||||..| ..| .  |.... |  ...... | ||..|.||  || |. .|.. 
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 405-648 6e-59 194.4 In-house 23-269 (274) alignment
Range on Protein: 405-648
Range on HMM: 23-269/274.0
CRLAENVAKNRYRDIAPYDATRVILR----EADTGDYINANTINmdipGFDLVNK-YVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKY
 ... .  ||||..| | . .||.|.    |..  .||||| |     |.| ..| |||.||||||||.||| |........|||||   |. . ||..|
ldvfgsqtknryktilPnensrvllesessededssyinanyik....GydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPDLDDR---LKFGpDLEVRCTRCDETPSFAYRDFIICNTATkeERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVP---TIVHCSAGIGRT
.||  |     ..| |.|.. .   |.  .  | ... ..    || |  . | .|||| .||| . .||.|| |.. |   . .   ..||||||||||
fPdaedyeiseryg.dveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIrVYMD
|. |... |.  ..... |  | ||   | .|  ..||. ||... .|..  |. 
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc.lylk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 407-644 2.3e-58 192.3 In-house 17-262 (270) alignment
Range on Protein: 407-644
Range on HMM: 17-262/270.0
LAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLV-NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD
 | . . |||.|| |  ||||.| |    ..  ||||| ..    |||   .||.||.||||.|...|| |.||...| |||.|  .|.|| || .||| 
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvr....GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

LDDRLKFGPDLEVRCTRCDETPSFAYRDFII-CNTATKEERIVlQMQYVAWPDHGVPDDSS------DFLDFVLRVRQCRVGMDV--PTIVHCSAGIGRT
  ..     | ... . . |. .  |.   .  ..  .|.|.|   .|..||||||| ..       . |  .  ||. .  .|   |..||||||.|||
epkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
|.||....|..|.| .. | .| |..  | .|. |.|.  ||.|. .|.. 
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 404-646 2.7e-58 192.0 In-house 32-277 (287) alignment
Range on Protein: 404-646
Range on HMM: 32-277/287.0
ACRLAENVAKNRYRDIAPYDATRVILR-EADTG-DYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP
|     .| |||| |. |.| |||.|  |.. | ||||||     ....   ....|||||.. ||.||| .|.|.||. ....| .|| .| ||.||||
aaeelaavkknryadvlPiddtrvllsaegelGsdyinany....vasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

DLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRV----RQCRVGMDV-PTIVHCSAGIGRTGVL
. .  .. |    |   .    | .. | . . .  |.| |.| |.....|||....  .  .. ||| |       | . .| | .||...||||.|.|
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

ITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
... . .   |    | .  .|   | .|  |.|.. |.....||..  |
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 396-644 9.4e-58 191.0 In-house 47-289 (319) alignment
Range on Protein: 396-644
Range on HMM: 47-289/319.0
KKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTtnverg
  .. ..  . | .|  |||. .| ..| ..| |.  .     |||||  ..    |.   .||.||||||.||..||| |.||.... ||.||      
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......

RVKCHKYWPDLDDRlKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDV--PTIVHCSAG
. || .|||   .  | .   .|. .  .||  .. ||. . . .  |. | . |  .  |||.|||| .||.. .| .||  .  ..   . .||||||
kdkcsqywplkivi.kee.rfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
.||||| |.... .  .. .. |   ..||  |.||. |.|  .||||.  |.. 
vGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 397-644 4.2e-57 188.8 In-house 12-253 (284) alignment
Range on Protein: 397-644
Range on HMM: 12-253/284.0
KPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTtnvergR
 .| ..  . | .|  |||. .| ..| ..| |.  .     |||||  |.    |.   .||.|.||||.||..||| |.||.... ||.||      .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

VKCHKYWPDLDDRlKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDV--PTIVHCSAGI
 || .|||   .  | .   .|. .  .|.  .. ||. . . .  |. | . |. .  |||.|||| .||.. .| .||  .  ..   . .||||||.
dkcsqywplkivi.kee.rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

GRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
||||| |.... .  .. .. |   ..||  |.||. |.|  .||||.  |.. 
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 402-644 2.3e-56 185.9 In-house 36-275 (315) alignment
Range on Protein: 402-644
Range on HMM: 36-275/315.0
MGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHK
  ..|  .|  ||||..| |.| .||.|    .    |||||      |...|  . |.|.||||. .|.||| ||.... | |||.|   |  ..|| .
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD-LDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLI
||||   |  .||  ..|     . .     | ... .  ..| | | | |.  |||.||. ..| .| ..  |.  .   . . .||||||.|||||.|
ywPdrkadsvefG.sikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

TMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
...  .  |. .. |  ...|.. |..|| |.||  .| |. .|.  
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 410-643 1.8e-55 183.0 In-house 43-273 (515) alignment
Range on Protein: 410-643
Range on HMM: 43-273/515.0
NVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD-LDD
|  ||||..| ||| .||.|    ..   ||.||      ||.||  . |.|.|||.. .|.||| .|.... | |.|.|   |  ..|| |||||   |
nfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

RLKFGpDLEVRCTRCDETPSFAYRDFIICNTATkeERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
 .|||  ..|     .       | . .        | | | ..  |||.||| ..| .| ..  |.  .  .  | |.|||||.|||||.|...  .  
svkfG.sikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvah

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
..  . |  ...|.  |..|| |.||  || |. .|. 
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 390-646 3.5e-55 182.2 In-house 26-279 (315) alignment
Range on Protein: 390-646
Range on HMM: 26-279/315.0
FDQLYRKKPGMTMG---ACRLAENVAKNRYRDIAPYDATRVIL--READ-TGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
| | |   ||  .      .  ||. |||| .| .|| .|| |   | |   ||.|||     |.|..  ..|.|||||....|.||| .|.|.  . ||
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanf....idGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv

MLTTNVERGRVKCHKYWPDLddRLKFGPdleVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTI
|||  ||. . |. |||||   .. .|.   .  || .|     |    .  .  .. | |.|..| .||| |||  .  ..... .|.| .     . .
mltnlvegekrkaekywpdk..kviyGk...itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaiv

VHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||||||.|||| .||... .  .||.. .   ....  |..|  ..|.|.||.|. .|..  .
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 408-649 1.2e-54 180.1 In-house 7-244 (250) alignment
Range on Protein: 408-649
Range on HMM: 7-244/250.0
AENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVkCHKYWPdLD
 .|  |||| || ..| .||.| . .     |||||  ..    |.|  . ..|.||||..|..||| ||.|. |. |||||. .| ... .|.|||  .
pqnkeknryadiialdssrvvLekekgdkesdyinasflh....gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.ve

DRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVG-MDVPTIVHCSAGIGRTGVLITMETAM
   |.| |. |     .|   .  | ... ..  ..|||| |...|.||| |||.     |... .|.. .    . | ||.||||.||.|  |.... .
kaekyG.dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

CLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDC
  .. .. |   ..... | .||  ... .|| || |.|.. ..|.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk.alds

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 408-644 1.2e-54 180.5 In-house 46-282 (297) alignment
Range on Protein: 408-644
Range on HMM: 46-282/297.0
AE---NVAKNRYRDIAPYDATRVILREADTG---DYINANTInmdiPGFDLvnKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRvKCHKYWP
||   |  |.||..| |||  ||.|.  ..    ||.||  .    .|.    .... | | ..||.||| ||.... . ||||. . || . || .||.
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv....kgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

DLDdRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPD--DSSDFLDFVLRVRQCRVGMDV-PTIVHCSAGIGRTGVLIT
|     .|| |. |  .  .|   |  |.. . . ..| .|.| | |.| |||. |.   . | .|...  ||.   .    | .|||.||.||||||.|
dkg.vttfG.dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

METAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
..  .. .. .. |  ...|.  |..|| |.||  ||||| .|.. 
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 409-643 5e-53 174.8 In-house 2-236 (237) alignment
Range on Protein: 409-643
Range on HMM: 2-236/237.0
ENVAKNRYRDIAPYDATRVILREADT-GDYINANTINmdipGFDLV-NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDR
|| .|||| .|  || .||.|. | .  |||||. ..    |||   .||.|||||| .. .||| |||... ..|||||  .|. ..|||||||. |. 
enkiknrygnivaydhsrvvlkgagsgsdyinatylk....gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

LKFGpDLEVRCTRCDETPSFAYRDFIICNTAT-KEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRV--RQCRVGMDVPTIVHCSAGIGRTGVLITMETAM
  .|  | |  .. .|   .. | ... .  | || |.. | |. .|||.|||. .. .| |  ..  |   |    | |.|||||.||||... ... .
aayg.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

CLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
   . .. |   . | .  ..|| .|||  || |. ..|.
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_PTPRN_pd Subfamily PTPRN 400-643 6e-51 167.9 In-house 46-289 (297) alignment
Range on Protein: 400-643
Range on HMM: 46-289/297.0
MTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINMDIPGfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKC
 |  ...  .|| |||.... ||| .|| |.|   |.. ||||| .|  . |       |.|.||||..|| ||| ||||| ...||.||.  | |  .|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpr...apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

HKYWPDLDDRLKFGPDLEV--RCTRCDEtpsFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTG
..||||    .    ....      ||.   .  | | . |  |.| | | |. ...||..|||  .  .|.|  .| ..  |   | .||||.| ||||
krywpdeGsevyhiyevhlvsehiwcdd...ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtG

VLITMEtaMCLIEANEPVYPLDIVRT---ERDQRPMLIQTAAQYKFVCEAII
| | ..  . |   .  |  .||. |    ||||| |..| .|..|.  |..
vyilid..lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 396-650 6.8e-50 164.6 In-house 35-281 (287) alignment
Range on Protein: 396-650
Range on HMM: 35-281/287.0
KKPGMTMGACrlAENVAKNRYRDIAPYDATRVILREAdTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK
..  .|..     .|  |||...| ..|  ||.|..    |||||  |.    |.   .....|..|. ||. .|| ...... | ||||. . |  . .
redevthnia..sqnkdknRltqilvpdnyrvllkge.hpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeev

CHKYWPDLDDrLKFGPdLEVRCTRCDETPSFAYRDFIICNTA-TKEERIVLQMQYVAWPDHG-VPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRT
|..|||. .  . .|.  ... .  . . ..  |.. . |.  ..... | | |. .|...| |..  . .| .  .... |   . . .||||...||.
cyqyWpeeks.vvlGe.yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIiRVYMDCI
.... ..|..   . .  .  .....  | |.|  .||..||||.....  .|.|. 
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindiv.leyldsf

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 390-648 7.5e-49 161.1 In-house 26-284 (290) alignment
Range on Protein: 390-648
Range on HMM: 26-284/290.0
FDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILR----EAD-TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
| .|   .   |.      .|  .||...| .||  |..||    . | | .||||  |.    |.   ..|.|.|||..||. ||| ..|....| |||
fkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTTNVERGRVKCHKYWPDLDDRLkFGPdLEVRCTRCDETPSFAYRDFIICNTAT-KEERIVLQMQYVAWPDHG-VPDDSSDFLDFVLRVRQCRVGMDVPT
||. .| |.|||..|||| | .  .|.  ... .   .. ..  | . . |. . .....| | |  .|...| |.. ..  | .  .... |   . . 
ltniieegkvkCqqYWpdsdtka.yge.fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsi

IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMD
.||||...||..|.....|..   . .  .  ...... | |.| ..||. ||..... ... |.|
vvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt.yld

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 390-644 1.7e-47 156.9 In-house 26-277 (439) alignment
Range on Protein: 390-644
Range on HMM: 26-277/439.0
FDQLYRKKPGMTMGACRLAEN--VAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
|...   .|  .  |. .|..   .||||.|....| |||.|.|        ||||| |.    |.   . |.|.|||  .|..||| .|.|.... |||
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyik....Gyyddklyiatqgpkkettddfwrlviekktvtivm

LTTNVErgrvkCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNT--ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD-VP
||  ||      .||||  |.   .| |. ||. |  | | .. | | . |    |. || |||..|.||||. || ..|  |||.  .  .    .  |
ltnlve.....sykywps.daevcyg.diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

TIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .||||||.|||| .|... |.  . ... |    ||.  |.||  ..|. .|| |. .|.. 
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

0051429 (Phosphotyrosine protein) phosphatases II 434-646 3.7e-47 156.6 In-house 3-225 (272) alignment
Range on Protein: 434-646
Range on HMM: 3-225/272.0
TGDYINANTINMDiPGFDLVNKYVAAQGPLPNTVNDFWYMvWEQRSTLIVMLTTNVERGRVKCHKYWP----------DLDDRLKFGPDLEVRCTRCDET
...||||. ...   .  . ... ...||||.|..|||.. .|.. . ||.|.. .||||.||..|||          | ..   .  .| |... .  .
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PSFAYRDFIICNT-ATKEERIVLQMQYVAWPDHGVPDDSsdFLDFVLRVRQcrvgmDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVY--------P
. . .| ... ..  ..| | |....| .|||||||...  .|...  ...     . | .||||||..|||... .   .  ....  |         .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
...|.  |.|||  .|| .||.|..||.. ..
eeaveelraqrpgavqteeqylflyeallell

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 392-648 8.6e-47 154.8 In-house 30-290 (325) alignment
Range on Protein: 392-648
Range on HMM: 30-290/325.0
QLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTINMDIPgfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMlTTN
.|   . |... .  . ||.||||.... ..| .||.|   ...   |||||. .. |.      . ..||| ||..|.||.| .| . |....|. .  
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk....kdvflaaqaPltatindlWrlvldWrcsvvvv.lne

VERGRVKCHKYWPDL-DDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDF---VLRVRQCRVG---MDVP
.. |  .| .|||.   .  .||. |||.    .|   . .| . . ..   | | | |.|. .|.| ||.   . .. .   |  | ..         |
ldlgkdrcavywpkemgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

TIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
 .||||||.|||||.|.. .|.  .  .  |  .. |.  | .|| ...|. || .. ||.. .|| 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_CG7180_pd Subfamily CG7180 388-647 4.1e-46 152.0 In-house 17-291 (296) alignment
Range on Protein: 388-647
Range on HMM: 17-291/296.0
AQFDQLYRKKPGMTMGACRL---AENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTL
......... | ...| |.    .||  |||. .. ||| .||.|.. |   . |||||  ..    .|   ..|.  ..|  .||..|| .|... .  
veyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisa

IVMLTTNVERGRvKCHKYWPDLDdRLKFGPdLEVRCTRCDETPSFAYRDFIICNT----------ATKEERIVLQMQYVAWPD-HGVPDDSSDFLDFVLR
.|.|| . .  . ....|||    . ..|. ..|  .. .. . .  | | .  .           . |.|||...|.  |.  . ||  .. ..... |
vvvLtktfdfak.mypsywpnks.keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VRQCRVGM-----DVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
||. |  .       |..|..| | .|.|| .... .. |.| .| |   . |.| | .|| |...  .||.. . .   ..
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

0041856 (Phosphotyrosine protein) phosphatases II 410-643 7.3e-45 148.1 In-house 1-168 (182) alignment
Range on Protein: 410-643
Range on HMM: 1-168/182.0
NVAKNRYRDIAPYDATRvilreadTGDYINANTINMDIPGFDlvnkYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTtnvergrvkCHKYWPdlddrlkf
|. ||||.|| ||| .|         |||||| . .. |. .    ..|.||||..||.||. |..|.. |.||.||         .. |||        
nldknrysdilpydhsr.......dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

gpdlevrctrcdetpsfayrdfiicntaTKEERIVLQMQYVAWPDHGVPDdSSDFLDFVLRVRQcrvgMDVPTIVHCSAGIGRTGVLITMETAMCLiean
                            ...|| ..| .|. ||||||||  ...|||. .|..     . |..||||||.||||.|. .   ..|    
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

ePVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
  | . ..|.. | .||. ..|  || |.  |. 
.gvsleeavklvrsrRpgmvitpnqyfflqlall

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 409-645 2e-44 146.4 In-house 53-282 (290) alignment
Range on Protein: 409-645
Range on HMM: 53-282/290.0
ENV--AKNRYRDIAPYDATRVILREADTGDYINANTINmdipGfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD-
.|    ||||.|..  | |||||..   |||. || ..    |  |   .. .||.| .|| |.| || ... . ||||   .| |. ||..|.|. .  
kntefkknrykdvvcndktrvilkdGydGdyvhanyvk....G..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

RLKFGpDLEVRCTRCDETPS-FAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQcrvgMDVPTIVHCSAGIGRTGVLITMETAMC
 | || .. | |.  |.  .    . . . .  .  | ..  .. ..|||. |.  .  .|  .  .|.    .  | .||||||||||| ....|... 
vltfG.eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglq

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
..     . .||.||. |. |   .|   ||  . |... .
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 409-643 2.5e-43 142.9 In-house 6-237 (239) alignment
Range on Protein: 409-643
Range on HMM: 6-237/239.0
ENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmDIPGFDlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD
 | ||||| .|  || .||.| .       |||||. .  |  |    . |.|.|| .  .  ||| |.|..|  .|||||  .|  . |||.||||   
vnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

rlKFgPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
  |.  .| |   . .    .  | |.. .    ||| | | ..  |||.|||. ..  | .  .. .  .    | ..|||||.|||| .. ... .  
..ky.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 . .. |  .. |.. |..|| ..||. || |.  |..
akkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 409-642 2.7e-43 142.9 In-house 7-237 (239) alignment
Range on Protein: 409-642
Range on HMM: 7-237/239.0
ENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmDIPGFDlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD
 | ||||| .|  || .||.| .       |||||. .  |  |    . |.|.|| .  .  ||| |.|..|  .|||||  .|  . |||.||||   
vnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

rlKFgPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
  |.  .| |   . .    .  | |.. .    ||| | | ..  |||.|||. ..  | .  .. .  .    | ..|||||.|||| .. ... .  
..ky.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAI
 . .. |  .. |.. |..|| ..||. || |.  |.
akkqktvdifnyvkairedrphmvqtseqyvfihlav

0036282 (Phosphotyrosine protein) phosphatases II 436-639 2.8e-42 139.7 In-house 3-163 (174) alignment
Range on Protein: 436-639
Range on HMM: 3-163/174.0
DYINANTINMDIPGFdlvnKYVAAQGPLPntvndFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlddrlkfgpdlevrctrcdetpsfayrdfiicn
|||||. ... .       ...| ||||.     ||.|..|...| .|||.. .|.|..||. |||.                                 
dyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

TATKEERIVLQMQYVAWPDHGVPDDSSdFLDFVLRVRQCRVG-MDVPTIVHCSAGIGRTGVLITMETAMCLIEaNEPVYPLDIVRTERDQRPMLIQTAAQ
. . .|| ..| .|. ||||||||.|  .|.|| .|....    . |..||||||.||||.|. .   ..... . .|  ||.||. | |||. .||  |
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFVC
|.|. 
yrfly

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 406-643 2.9e-42 139.5 In-house 29-263 (283) alignment
Range on Protein: 406-643
Range on HMM: 29-263/283.0
RLAENVAKNRYRDIAPYDATRVILREADTgDYINANTINMDIpGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlDD
   ||  |||...| |.|  || |.     |||||  | ..    .  .||..||.|| .|| ||| ||.... | |||||   |  |.|| .|||  . 
sadenkrknrnqeivpadqwrvelksesr.dyinavfipvsk.sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.rG

RLKFGPdLEVRCTRCDETPSFAYRDFIICNT-ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMC
  ..|. . |   .     ||  . ... .  ..|.. ..   |.. | . |       .. | . . . .   . | .||||.|||||.|.|.. ... 
sedyGe.ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 . ..  |    .|.  | ||.|..||  |||.| |...
daltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 404-644 4.4e-41 135.6 In-house 39-234 (392) alignment
Range on Protein: 404-644
Range on HMM: 39-234/392.0
ACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGrvkchkyw
...   |. ||||..| |||..||.|    .    ||.||      ||.||  . |.|.||| . ...||| ||.... | |.|.|   |          
vaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pdlddrlkfgpdlevrctrcdetpsfayrdfiicntATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITME
                                      .. | | | ... |||..||  .| .| |.  |.        | |.|||||.|||||.|...
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

TAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
. ..  .    |  ...|   | .||...||  || |.  |.. 
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

0046846 (Phosphotyrosine protein) phosphatases II 436-644 1.8e-40 133.9 In-house 13-171 (176) alignment
Range on Protein: 436-644
Range on HMM: 13-171/176.0
DYINANTINMDipgfdlvnKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlddRLKFGPdlevrctrcdetpsfayrdfiicn
|||||| | ..        ...| |||||.|. ||. |..|.. |..|.||. || ||.||. |||.     |.|                         
dyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi........................

tatkeerivlQMQYVAWPDHGVPDDsSDFLDFVLRVRQCRVGmDVPTIVHCSAGIGRTGVLITMEtamcLIEANEPVYPLDIVRTERDQRP-MLIQTAAQ
          | ... ||||||||. ...|...  .|...   . |..|||||||||||.|. .     |.| .  . ....... |.||| . .|| .|
..........qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YKFVCEAIIR
|.|. |.. .
yrflyefell

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 410-647 1.3e-39 130.6 In-house 55-290 (305) alignment
Range on Protein: 410-647
Range on HMM: 55-290/305.0
NVAKNRYRDIAPYDATRVILREADTGDYINANTINMDI-PgfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLD-D--
...||||.|.   | . | | .    ||| || .   . |     .....||||| .|...||.|| ...   ||||   || |..|| .|||    .  
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmip....ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

RLKFGPDLE-VRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRqcrvGMDVPTIVHCSAGIGRTGVLITMETAMC
 || |  .| |  ..  |  .      .  . . ...  | ..|.  ||| |||      |...  .|    |  || .||||||||||| ....|  . 
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyile

LIEANEPVYPL-DIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 |  | |. |. ..|.. |||| . ||.  || |.   ..  ..
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

0043147 (Phosphotyrosine protein) phosphatases II 434-639 2.3e-39 130.2 In-house 4-154 (172) alignment
Range on Protein: 434-639
Range on HMM: 4-154/172.0
TGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNvergrvkchkywpdlddrlkfgpdlevrctrcdetpsfayrdfii
  |||||. ... .      ....| ||||.||..||| |..|.  |.||.||.                                              
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

CNTATKEERIVLQMQYVAWPDHGVPdDSSDFLDFVLRVRQ-CRVGMDVPTIVHCSAGIGRTGVLITMETAMclieanEPVYPLDIVRTERDQRPMLIQTA
.......|| ..| .|. ||||||| ... .|.|.  ... . .  . |..||||||.||||.|. .   .      . . ....|.. |..||. .|. 
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

AQYKFVC
 ||.|..
sqyrfly

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 387-577 5.3e-39 128.8 In-house 10-199 (297) alignment
Range on Protein: 387-577
Range on HMM: 10-199/297.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTG-DYINANTINMdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
 |. | |.... | .. ...    . |||||||  .| ||| |. . |. |||||. . .  |  .   ||. ||||| .||.||| .|.||    |||.
eaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TTNVERGRVKCHKYWPDLDDRLKFGPDLEVR--CTRCDETPSFAYRDFIICNTatKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVG
.   | || ||  |||. ..  .  .|. |    .  ||       .. .     .|.| |  .|...||||||| |  |   |  .|  | . 
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcsccia

0049260 (Phosphotyrosine protein) phosphatases II 447-639 2.3e-38 126.6 In-house 2-143 (152) alignment
Range on Protein: 447-639
Range on HMM: 2-143/152.0
IPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWpdlddrlkfgpdlevrctrcdetpsfayrdfiicntatkeerivlQ
|.|.   ....|.|||.|||..||| |..|.  | |||||. .|.|..||..|.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

MQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMclieanEPVYPLDIVRTERDQRPMLIQTAAQYKFVC
 ... ||||||||.|  .|...| .....   . |..||||||.||||.|. .   .        | ....|.  | .||. ...  |..|. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 381-646 4.7e-38 125.9 In-house 11-277 (307) alignment
Range on Protein: 381-646
Range on HMM: 11-277/307.0
LDTGMA--IAQFDQLYRKKPG-MTMGAcrLAENVAKNRYRDIAPYDATRVILRE-ADTGDYINANTINMDIPGfdlvNKYVAAQGPLPNTVNDFWYMVWE
|| |.   . .| .| .|.|  .|. |  .  |  ||||.|.   | .|....    . ||| || . . |      .|...||||| ||. .|| |. .
ldkgvqalvdefrvlakktpegvtvea..fsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiq

QRSTLIVMLTTNVERGRVKCHKYWPDLD-DRLKFGPDLEVRCTRCDETPSFAYRDFIICNTA-----TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLR
..   ..||   .| ...||..|||  . ..| ||   .  .     .  .|  . .|  |.     ... | . ..|.  |||.|||.     ....  
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

VRqcrvGMDVPTIVHCSAGIGRTGVLITMETAMCL-IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||    .   | .||||||.||.| ....   .   |.  .     ..|.  |.||.  ||| ||| ..   ..  .
vr....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 388-647 2.7e-37 123.1 In-house 19-293 (301) alignment
Range on Protein: 388-647
Range on HMM: 19-293/301.0
AQFDQLYRKKPGMTMGACRlAENVAKNRYRDIAPYDATRVILREADTGDYINANTINMD-IPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLT
.|...|.....  ..  ..  || | ||...|..||  |.||..  . |  . . ||   | |.   .|..|||||. .|. ||| ..|... . |||.|
eqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

TNVERGRVKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFII--CNT-------------ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRV
   |. . ||..|||. . . .    ..|  .     |.|  |.. .   ..             ..|. . |||.| . ||..||  .    |  .  |
nlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddv

--RQCRVGmDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIiRVYM
  || ..|   | .||||....|.|| .... ..    |.  |   ..... | ..|  ..|  || .. ..|   |.
ihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmyl

subfamily_ptpA1_pd Subfamily ptpA1 409-603 4.6e-37 122.7 In-house 46-253 (418) alignment
Range on Protein: 409-603
Range on HMM: 46-253/418.0
ENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINMDIPgfdlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD
 | .|||| .| | . ||| |..    .  |||||| |.   |     ......|||||||. ||| ||||.|  .||||. . |  |.|| .|||.   
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.....kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

R---LKFGPDLEVRCTRCDETPS---FAYRDFIICN---TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL--RVRQCRV----GMDVPTIVHCSAGI
      .|   ||  |   |         |. |  |   |   | | . | ||  |||| .|| .  | ...     || ..      .|| |||||||.
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGVLITMETAM
|||| . |    |
grtgtfctavimm

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 389-647 1.5e-36 120.7 In-house 27-288 (305) alignment
Range on Protein: 389-647
Range on HMM: 27-288/305.0
QFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTGDYINANTINMdiPGfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTN
.|  . | .    | | . |..  ||||.|.   |  || |. .   .|| || .    |     .... .| || .|  ||||| ....   | ||   
efvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..pt..npkrfictqaplektcadfwymclqdkveaifmlcnl

VERGRVKCHKYWPDLD-DRLKFGPDLEVRCTRCDETPSFAY---------RDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRvgm
.|.|  ||..|..  | | |.|  . .    ... . .. .         .  .. . . .. | | .  .. ||| |||      |... . |  .   
lekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk...

dVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPL-DIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
  |..||||||||||| .. .|  .  . | . .     |..  |.||   ||| ||| || . |.  . 
.gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 409-646 3e-36 119.8 In-house 34-270 (285) alignment
Range on Protein: 409-646
Range on HMM: 34-270/285.0
ENVAKNRYRDIAPYDATRVILREADTgDYINANTinMDIPGFDLvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD-LDDRL
 |   ||| |.   . |||.|.. |  ||| |.   | .|| |  . |...|||||.|..|||.|..... . ..|| | .| |  ||  |.|. | . .
anpdlnryadvrcieetrvvlknhdr.dyihasw..mrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

KFGpDLEVRCTRCDETP--SFAYRDFIICNT--ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRvGMDVPTIVHCSAGIGRTGVLITMETAM
|||   |.  | | |       .  . . ||  |. |   . ..|   |||.  |.|.  ....   |..     . |  ||||||.|||  .. .. | 
kfg.kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpicvhcsagvgrtatfvgidyat

CLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
  |  |  .  |||||  |  |   .|.  |. |.   ..  .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf

0049772 (Phosphotyrosine protein) phosphatases II 400-642 3.7e-36 120.8 In-house 36-276 (314) alignment
Range on Protein: 400-642
Range on HMM: 36-276/314.0
MTMGACRLAENVAKNRYRDIAPYDaTRVIL--READTGDYINANTINMDipgfdlvNKYVAAQGPLPNTVNDF----------WYMV--WEQRSTLIVM-
.|. ...| .|  |||| || |.| .||||   . .. |||||. ..         .|..|.||||..||.||          | ||  .....  ||| 
ltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LTTNVERGRVKCHKYWPDLDdrlkfgpdlevrcTRCDETPSFayrdfiicntatkeERIVLQMQYVAWPDHGVPdDSSDF
                    |..  ..|   . .....|              ..... . |              || ...  .. .||...| ...||
rdevladelsrLdaAlgKtpllildgngneptaadlellk.............eelydpelf..............erlgikylripvpDgsap.lledf

LDFVLRVRQCrvGMDVPTIVHCSAGIGRTGVLITmeTAMCLIEAnePVYPLDIVRTERDQRP-----MLIQTAAQYKFVCEAI
..|.  ....    . |..|||.||.||||....  .|....     | . ....  | .||      .|..  || |. ||.
deflefieea..dkggpvlvHCkaGkgRtgtfvv..aaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefileal

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 372-640 5e-31 102.4 In-house 15-284 (310) alignment
Range on Protein: 372-640
Range on HMM: 15-284/310.0
ESFMLLQEGLDTGMAIAQFDQLYR-KKPGMTMGAcrLAENVAKNRYRDIAPYDATRVILR--EADTGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVN
| |..  | |     . |. .|   . . .|. |    ... |||| |.   |..|| |.   .  .||| || .. .     | . .. .||||  |. 
enfiiateklgieglvkqyrkldakqdssltyea..ykkymhknrysdvvcldtsrvklkidksryedyihanyvktny....lrstficsqgplqhtii

DFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPdleVRCTRCDETPsfayRDFIICNT---------------ATKEERIVLQMQYVAWP
||| |....|.  |..|   .| || ||  ||| |     .|    .| |   |.      .| |||                |  .|  |  ...  ||
dfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc...irvtnlsess....eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwp

DHGVPDDSSDFLDFVLrVRQCRVGmdvPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCE
| ||||.    .   | . | | |   | .||||||..|..|..... ..  ..  . |   ...   . .| . |||  || ..  
drgvpdekchtvpqrl.laqvrhg...pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr

subfamily_egg_pd Subfamily egg 408-650 4.8e-30 99.3 In-house 38-274 (307) alignment
Range on Protein: 408-650
Range on HMM: 38-274/307.0
AENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERgrVKCHKYWPDL-
..|  | | . .   | .|| |.      ..|.| || ..    |  |.|... || || |||.||| ||....   |||||...|    .|. |||   
dnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

DDRLKF-GPDLEVRCTRCDETPS--FAYRDFIIcNTATKEERIVLQMQYvawpDHgvpDDSSDFLdFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITME
.| |..    |.. . . |...   |    . .   . .||| .   |.    |    . |||   . ||| .    .  |..|..  |. ....|...|
sdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg....dv...nnssdvy.splrvlrklrnlskpvvvqdilGvskaatlvaie

TAMCLIEANePVYPLDIVRT---ERDQRPMLIQTAAQYKFVCEAIIRVYMDCI
.|.. .    |..   . |.    | .|.. .... .| ||   .. .. | |
iallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi

0044763 (Phosphotyrosine protein) phosphatases II 421-644 3.2e-29 97.2 In-house 1-169 (178) alignment
Range on Protein: 421-644
Range on HMM: 1-169/178.0
PYDATRVILREADT---GDYINANTINmdiPGfdlvnKYVAAQGPlpntvNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDrlkfgpdlevrc
|.| |||.| .      .|||||. |    ||      |.....|      |.. ...|.  |.||.||...|.|..||..|||.  .            
pldrtrvllsnleglersdyinaseil...pg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

trcdetpsfayrdfiicntatkeerivLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLieanePVYPLDI
                           .|.... .||||||| .. ||.||  .....   . |..||||||.||.|.|. .   ..|      . . ..
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleea

VRTERDQRPmLIQTAAQYKFVCEAIIR
..  | .||  ...  |.....|   |
ielvrerRp.ivpnpgqlrqLyefelr

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 386-642 4.4e-29 96.4 In-house 17-267 (288) alignment
Range on Protein: 386-642
Range on HMM: 17-267/288.0
AIAQFDQLYRKKPGM--TMGACRLAENVAKNRYRDIAPYDATRVILReADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
|..  .. ||  |       .    .| ...||...   |.||| |   |.  ||.|| .          .. . || ||  |.. .| |. |.    ||
aveglkkeyrdspneasidiidsfianptrdryenlprcditrvkls.ddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyiv

MLTTNVERGRVKCHKYWPD-LDDRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRvgmdVPT
||.  .|.|. |  .|.|  | .. ..|    |   . ..         .  .  ..|. || .. .  |.|.|||..   .| .. ......     | 
mlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPi

IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAI
.||.|||.|||| || .  |.  .  .. .    ..   |..|   |||  || .|   .
vvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

PTPc_DSPc_SM00012 544-643 4.6e-29 96.1 In-house 2-104 (105) alignment
Range on Protein: 544-643
Range on HMM: 2-104/105.0
VLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD--VPTIVHCSAGIGRTGVLITMETAMCLIEAN-EPVYPLDIVRTERDQRPMLIQTAAQYKFVCE
| ...| .|||||||..|...|...  |....   .   |..||||||.||||.......... .|.. . |  ..||.  |.||| ..|| .|| |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AII
|..
all

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 413-638 2.6e-28 93.6 In-house 53-273 (301) alignment
Range on Protein: 413-638
Range on HMM: 53-273/301.0
KNRYRDIAPYDATRVILREADTGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRLKFGP
|.||  .     | | . .  .   | || |. .       ....|.||||.|| .||| |.       ||||. .||.   ||..| | .  ..|. | 
khryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

-DLEVRCTRCDETPSFAYRDFIICNTATK-EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCrvgmDVPTIVHCSAGIGRTGVLITMETAMCLIEAN
 ..... .      .   | . . ... | . | |.  ||. |.|.|||    .  |..  |..     . | .|||||||||.  .|. |     .||.
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarevead

EPVYPLDIVRTERDQRPMLIQTAAQYKFV
  .   . ..  |..|   .||  |  ..
ptieltealkhlrehrwngvqtnsqlywm

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 409-606 3.5e-28 93.3 In-house 46-289 (350) alignment
Range on Protein: 409-606
Range on HMM: 46-289/350.0
ENVAKNRYRDIAPYDATRVILR-----------EADTGDYINANTINMDIPGFDLVN--KYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK
|  |||||..| ||. .||.|.              | |||||| ...  .. .     ||.|.|.|||.||.||. .. .   ..|..||..|| .. |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHKYWPDL--DD-RLKFGPDLE--------------VRCTRC------DETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL---
|..||...  ||  .|.    |              |. .        |..    . . .  . |. .  .|.|.|.  |.| ..  .  ..|  .    
cyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkn

-------RVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLI
                  | .||||||.||||.|.|..  .  .
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 403-638 6.4e-28 92.2 In-house 30-261 (281) alignment
Range on Protein: 403-638
Range on HMM: 30-261/281.0
GACRLAENVAKNRYRDIAPYDATRVILRE----ADTGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHK
 .     |  |||| .|   | .|| |.      .. ||| || |   .    |   |. .|||  .|  ||| |.|.. .| ||||   .|  | || .
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf....lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPDLDD-RLKFGpDLEVRCTrcDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRqCRvgmDVPTIVHCSAGIGRTGVLI
|.|      |.|   | |     | |   .     .  .   | |.. .  .  |||  ||. |  .|  . ..| .|     | ..|||||.||.| |.
yfprnahcclqfd.klsvsye..dstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.ar...stppvihcsagvgrsgtlm

TMETAMCLIEANEPVYPL-DIVRTER-DQRPMLIQTAAQYKFV
..| |.  | .   .  . .||   |   |   .||  || ..
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymli

0051082 (Phosphotyrosine protein) phosphatases II 436-640 8.5e-28 92.2 In-house 4-147 (151) alignment
Range on Protein: 436-640
Range on HMM: 4-147/151.0
DYINANTINmdiPGfdlvnkYVAAQGPLPntvnDFWYMVWEQRSTLIVMLTTNVERGrvKCHKYWPDLDdrlkfgpdlevrctrcdetpsfayrdfiicn
||||.. .    .|      . . .|||.    ||. ...|.  . ||.|.. .|||  .|..|.|.|.                               
dyinfsyvt...gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................

tatkeeRIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQcrvgM-DVPTIVHCSAGIGRTGVLITMETAMCLieanepVYPLDIVRTERDQRPMLIQTAAQ
      . ||..... |||.|.|.    .|.|.  ...    . . |..||||||.||||.|. .   ..       | . ....  | .||...|.  |
......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YKFVCE
. |.  
flfqlf

FERM_C FERM C-terminal PH-like domain 12-96 1.4e-26 82.9 Pfam-A 4-87 (90) alignment
Range on Protein: 12-96
Range on HMM: 4-87/90.0
GSEIAIGVVSAGLSIFQNGVRI--NQFSWAKIVKISFKRKQFFIQQRReigETRDMVIGFNMTSYRACKNLWKSCVEHHTFFRMVDP
|.....|| . || |...  ..  ..|.|..| |.|||.|.|.|..|    |... |. |.....|..|.|.|.|.|.|..||   .
gtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrrk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 403-642 1.7e-26 87.8 In-house 25-255 (267) alignment
Range on Protein: 403-642
Range on HMM: 25-255/267.0
GACRLAE-NVAKNRYRDIAPYDATRVILREAdTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTnVERGRVKchKYWP
 .. .|| | ..||. |  ||| ||||||.  . .||||  ..    |.   |.... |.|| ||. ||. .. .|. . ||.||. |  . ..  ..||
isqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltk.vftdnir..lfwP

DLDDRLKFGPDLEVRCTRCDETPSFAyrdFIICNTATKEER--IVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGmDVPTIVHCSAGIGRTGVLITM
    . |   || |  .   |   .     |  .   |.|    |    |  |            |  .|   |   | . | .|.||.|.||.| ....
Pkmgqakkyqdltvehslekeendyq...iitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqleng.nrPlvvacsdGvGrsGtflvi

ETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAI
.. .  .  .. .   | .|  |.||. |..|  .| .. | .
dsqleraktegvsdifdflrkirsqriglvdtkeryiyihell

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 413-645 1.9e-25 84.3 In-house 46-275 (312) alignment
Range on Protein: 413-645
Range on HMM: 46-275/312.0
KNRYRDIAPYDATRVILReADTGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGpD
 ||| .|  .|  |  |   |   || || ...        ...|..|||| ||.  || ..    || |..|.. || |  || ||  |.   ...  |
lnrypniqcwdrgrftla.gdenfyihanfvkict....kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle.d

LEVRCTRCDET-------PSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSsdflDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
  |    | |           ..| . .   || .|  . . |. .|||||.||      |  ||.  .      | | |||||.|||| |. .|. .. 
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc....dtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaa

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
.         |.    | .|   ... .|| ..  ... .
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

0048076 (Phosphotyrosine protein) phosphatases II 526-644 2.9e-23 77.6 In-house 36-141 (145) alignment
Range on Protein: 526-644
Range on HMM: 36-141/145.0
FayrdfiiCNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGmDVPTIVHCSAGIGRTGVLItmetAMCLIEAnEPVYPLDIVRTERDQR
.       ... . .|| ..| .|. ||||||||.....|.|.  .....   . |..||||||.||||.|.    |..|.   . | . ....  | ||
l.......tselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtlv....aaylmll.lgvsleealelvrsqr

PMLIQTAAQYKFVCEAIIR
|. ...  |..|..|.. .
pgavpnpgqlrflyefele

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 380-646 5.1e-23 75.9 In-house 22-285 (302) alignment
Range on Protein: 380-646
Range on HMM: 22-285/302.0
GLDTGMAIAQFDQLYRKKPGMTMgaCR-LAENVAKNRYRDIAPYDATRVILReADTGDYINANTINmdIPGFDlvNKYVAAQGPLPNTV---NDFWYMVW
 |||.   ..|...   |  . .  |.   .|..||.  |.  .|...|.|  |   .|.|| ...  .| .   .. . || |  ...   ..|| ||.
sldtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle.aepdsyvnaskve..vPelt..rsiilaQlpkvdsedsveeFWrmvf

EQRSTLIVMLTTNVERGRvKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAyRDFIICNTATKEERIVLQMQ--YVAWPDHGVPDDSSDFLDFVLRVRQ
... . .|.|  . |  .   ....| . .  |   .. |   . ...   .   ..|          || .      |... ||.  ..    .  | .
qekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfa

CRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
  .  | .|..    |.|| |...|. .|.. ..... .   .||.. | |||  .... || ..  |..   
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 416-648 2.9e-22 74.1 In-house 24-261 (290) alignment
Range on Protein: 416-648
Range on HMM: 24-261/290.0
YRDIAPYDATRVILREAD---TGDYINANTINMDiPGFDLVNKY--VAAQ-GPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRV----KCHKYWPDLDD
  ...   ||||.|..     . ||| || . .   |  |.      ..       |...||.|. . ... .|||  . |. .      | || |.  .
RlevpLveatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg

-RLKFGpDLEVRCTRCDETPSFAYRDFIICNTaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRqCRvgmDVPTIVHCSAGIGRTGVLITMETAMC
  |||. .|.|.|.   .   .  |  ..     .||  |   ... | .  |..|.  .|. .  |. ..   . | ||||  || |  .| ... .. 
eelkfk.gltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaaiilgyQ

LIE-ANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
.|   .. |   |.. . | || ..|..| .. ||  .|.   ..
kiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie

0048179 (Phosphotyrosine protein) phosphatases II 538-640 6.8e-21 70.0 In-house 43-139 (144) alignment
Range on Protein: 538-640
Range on HMM: 43-139/144.0
TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVgMDVPTIVHCSAGIGRTGVLITMEtamcLIEANEpVYPLDIVRTERDQRPMLIQTAAQYKF
. .|| ..| ... ||||||||.....|.|.  .....   . |..||||||.||||.|...     |.  .  . . ....  | .||. ...  |..|
efleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrf

VCE
..|
Lle

subfamily_CG42327_pd Subfamily CG42327 412-574 4.7e-20 66.5 In-house 30-193 (319) alignment
Range on Protein: 412-574
Range on HMM: 30-193/319.0
AKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipG-FDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD---LD
 |.|. .. |   |||.|..    |   |..|. .     |  |  | |.||| .| ..  ||| .||||.|  || ||   | |  .| .|.|    ||
dksrvinvvPlPetrvvlqrigdddkdeyldasyvr....GyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

DRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYvAWPDHGVPDDSSDFLDFVLRVRQC
..  .| |. |     .    .|   ... .   .| | .    |  |.. .|| . . ..  .|.||. 
ntslyG.dilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

PDZ PDZ domain (Also known as DHR or GLGF) 252-325 8.2e-20 60.9 Pfam-A 2-74 (81) alignment
Range on Protein: 252-325
Range on HMM: 2-74/81.0
IRMLPDDRGRFGFNVKGGADQG-APIIVSRVAPNtPADLCIPrLNEGDQILQINGKDASTFTNEQLVSTIRALGE
... .. ||..||..||| |..  .|.||.| |. .|. . . |.|||.||..||.| ....... |  |.  ..
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg

subfamily_eak_pd Subfamily eak 391-568 4.8e-19 62.9 In-house 33-204 (332) alignment
Range on Protein: 391-568
Range on HMM: 33-204/332.0
DQLYRKKPGMTMGACRLAENVAKNrYRDIAPYDATRVILREAD--TGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTN
 .| .... ...   .  |.| .|   .| |||   | |  .      ||||  ...     .. .||. .  .  . |  || || ||.|  ||.|  .
adlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefs....evGrkyiltGiasedkvfafwqmvleqkspaivqlled

VERGRVKCHKYWPDLD-DRLKFGpDLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDdSSDFLDFV
|| .  |  ||.||   . ||||  |.| .    .   . .| ...      |   ||  ..  | .  .|    ||| . 
velkleksdkyfpdktreelkfG.ildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk.yedflalr

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 455-638 8.3e-19 62.5 In-house 5-195 (198) alignment
Range on Protein: 455-638
Range on HMM: 5-195/198.0
KYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICN--TATKEERIVLQMQYVAW
.|.|.| || .|. ||| ||||  |  |||.  .     .    |||  .        | | .      | ..   .|..|  ||    | . . |. .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPDdSSDFLDFVLRVRQCR----VGMDVPTIVHCSAGIGRTGVLITMETAMCLIEA-NEPVY-PLDIVRTERDQRPMLIQTAAQYKFV
 ..  |.  . |. ||.  |.         | | ||||| | | |||.....  .   |  .  |   ... .  |. |  .| .  .|.|.
kekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 454-638 8.4e-19 62.5 In-house 5-196 (199) alignment
Range on Protein: 454-638
Range on HMM: 5-196/199.0
NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICN--TATKEERIVLQMQYVA
 .|.|.| || .|. ||| ||||  |  |||.  .     .    |||  .        | | .      | ..   .|..|  ||    | . . |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDdSSDFLDFVLRVRQCR----VGMDVPTIVHCSAGIGRTGVLITMETAMCLIEA-NEPVY-PLDIVRTERDQRPMLIQTAAQYKFV
| ..  |.  . |. ||.  |.         | | ||||| | | |||.....  .   |  .  |   ... .  |. |  .| .  .|.|.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 382-642 8.9e-19 62.2 In-house 20-275 (303) alignment
Range on Protein: 382-642
Range on HMM: 20-275/303.0
DTGMAIAQFDQLYRKKPGmTMGACRLAENVAKNRYRDIAPYDATRVILREAdtgDYINANTINMDIpgfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTL
|. .|. .|...    |  ..   .. .|. |||. |.   | ..| | ..    || |. ...|       .| . .| ||. |  ||| |. ||.   
daniavnefekvvsylpp.svsknqfvknmdknrfvdvicldhskvklsds...syihasylelds.....skkailtqlplshtaadfwqmiieqkvkc

IVMLTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCD---ETPSFAYRDFIICNTATKeeRIVLQMQYVAWPDHGVPDD-SSDFLDFVLRVRQC--R
...| |. |  ..  .  .|  .| |||  .  .|         .  .. .   . |   |   ..   .| |||   .| | |. |.  . ...    .
vlllltdseydklggdsvfprnqdflkfe.ersirvgefkrvelgdgwvlkvlsvsngdyk..sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrk

VGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPL-DIVRTERDQRPMLIQTAAQYKFVCEAI
     ||.    .| ||.| .  .|||   . ....   |   . . |. |   .|  .|. .|   .
ysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 466-635 9.8e-18 59.1 In-house 40-210 (255) alignment
Range on Protein: 466-635
Range on HMM: 40-210/255.0
TVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDF
||. |. ..  .... .|||.   | |..||..|.| ..|..||.  |..| .|.    . .  .. .   .  |. . |   .|  |...  |... . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFVLRVRQCRvgmdvPTIVHCSAGIGRTGVLITMETAMC----LIEANEPV--YPLDIVRTERDQRPMLIQTAAQY
|  .  ||. .     . .||||.||||.  .. .| .       ..  | |    | ...  | .|.  |.|  | 
lnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 460-648 2.7e-17 57.2 In-house 97-290 (302) alignment
Range on Protein: 460-648
Range on HMM: 97-290/302.0
QGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD-LDDRLKFGP------DLEVRCTRCDETPSFAYRDFIICNTAT--KEERIVLQMQYV
  |  .|.. .| .. . . ...| |.. || .  || .|. | ....||||       ...    .  .  ||      | |. .  | .. |  ... 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPDDSSDFLDFVlrvRQCRVgMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
|||||| |...   || .   . |        .||||||.|||| |...   . |   ..    |.||   |. |   .|.. |  ..   . .  |.
awpdhGapkeaytaldil...kfces.ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 538-645 3e-16 53.8 In-house 85-193 (440) alignment
Range on Protein: 538-645
Range on HMM: 85-193/440.0
TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYK
  | | . |..| .|||.|||  ..  | ..  | ...    . | .|||||| |||||.|.... .   . .. .  . .. . |..|| ..||  || 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FVCEAIIRV
|| ||..  
fvheavleg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 409-503 1.4e-15 51.5 In-house 47-156 (349) alignment
Range on Protein: 409-503
Range on HMM: 47-156/349.0
ENVAKNRYRDIAPYDATRVILREA--------------D---TGDYINANTINmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVER
|  |||||.|| ||. .||.|...              |     |||||| ..  .. ..  .||.| | ||| ||.||. ..  ..  |.. |. . | 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylk..ltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

GRVKCHKYWPDL
.  ||..|| .|
slekcdiywqel

subfamily_hpo-7_pd Subfamily hpo-7 463-647 2.1e-15 51.3 In-house 43-228 (263) alignment
Range on Protein: 463-647
Range on HMM: 43-228/263.0
LPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDS
| .|.. |. ..  .... .|||.   | |..|| .|.| ..|...|.  ...| .|.  . .    ....      |. . | . .|. |...  | ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

SDFLDFVLRVRQCRvgmdvPTIVHCSAGIGRTGVLITMETAMC----LIEANEPV--YPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 . |  .  .|. .     . .||||.||||.     .|..       ..  . |    | ...  | .|.  |.|  |  |    .. . .
reilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl

FA FERM adjacent (FA) 104-147 8.5e-14 40.2 Pfam-A 2-45 (47) alignment
Range on Protein: 104-147
Range on HMM: 2-45/47.0
TFFQLGSKFRYSGRTESQTMEDTKKRLAEKEISRSSPNKRAFRR
 || |||||||||||| |..|. ...  ...    || ||  .|
kffslGSkFRYSGRTekQvieesreigrkppsfeRspskrylsr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 578-643 8.9e-13 42.7 In-house 227-292 (297) alignment
Range on Protein: 578-643
Range on HMM: 227-292/297.0
MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 .....||||||.||.||..  .. .  .  .       |..  |.||..|.||  |.... .|..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 406-485 4.7e-10 33.5 In-house 33-116 (347) alignment
Range on Protein: 406-485
Range on HMM: 33-116/347.0
RLAENVAKNRYRDIAPYDATRVILRE--------ADTGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
    ...||| .|    |||||.|           |.  ||||  |..|    .  ..|. .| |||.|| ||| ||   . | .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd....naskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 400-461 6.9e-10 33.0 In-house 34-95 (95) alignment
Range on Protein: 400-461
Range on HMM: 34-95/95.0
MTMGACR----LAENVAKNRYRDIAPYDATRVILREADTGDYINANTINmdipGFDLVNKYVAAQG
|| ||         |. |||. .| |||||||.|      |||||  ..    |.   | |.||||
mtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvd....gyarkncyiaaqg

subfamily_CG42327_pd Subfamily CG42327 581-641 4e-09 30.6 In-house 249-310 (319) alignment
Range on Protein: 581-641
Range on HMM: 249-310/319.0
PTIVHCSAGIGRTGVLITMETAMCLIEAN-EPVYPLDIVRTERDQRPMLIQTAAQYKFVCEA
| .|||| |.||||..|. . |.  .| . . |   ..|   | .|   ..|  ||.|.   
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_PTPDC1_pd Subfamily PTPDC1 547-640 5e-09 30.8 In-house 85-170 (182) alignment
Range on Protein: 547-640
Range on HMM: 85-170/182.0
MQYVAWPDHGVPDdSSDFLDFVlRVRQCRVGMDvPTIVHCSAGIGRTGVLItmetAMCLIEANEpVYPLDIVRTERDQRPMLIQTAAQYKFVCE
.  ..|.|.||.      || | .| .  .  .  . ||| || |||||||    |  |. |.. . . . ... |..||  |||  | ..| |
vynfgwkDygvas.leriLdiv.kvvafalqeg.kvavhChaGlGrtGvli....acylvyakr.ltaekaiklvrskrpksiqtreqvelvke

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 583-643 1.1e-08 29.4 In-house 2-62 (69) alignment
Range on Protein: 583-643
Range on HMM: 2-62/69.0
IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
.||||.| |||| .|..   |  | ..  |  .. |.  |  |||..    .| |. .|..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 583-643 1.8e-08 28.6 In-house 1-61 (69) alignment
Range on Protein: 583-643
Range on HMM: 1-61/69.0
IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
.||||.| |||| .|..   |  | ..  |  .. |.  |  |||..    .| |. .|..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 537-608 8.6e-08 25.9 In-house 213-294 (349) alignment
Range on Protein: 537-608
Range on HMM: 213-294/349.0
ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFV----------LRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEA
|...  ..||.|.  |.| ..  .   .|  .                      . .|||||| ||||||.|..  . ..| 
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsilep

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 454-558 2.7e-07 24.5 In-house 137-237 (244) alignment
Range on Protein: 454-558
Range on HMM: 137-237/244.0
NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTnVERGrvkcHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWP
 .|. .| || .|  ||| |. |.   ..|.| . ||       .|||| .    .  |. |  |  ||       .. |     .  . .  .|   ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV-P
  |  |
sdgttp

0038934 (Phosphotyrosine protein) phosphatases II 545-638 2.8e-07 25.9 In-house 80-169 (194) alignment
Range on Protein: 545-638
Range on HMM: 80-169/194.0
LQMQYVAWPDHGVPDDSS---DFLDFVLRVRqcRVGMDVPTIVHCSAGIGRTGVLItmetAMCLIEANePVYPLDIVRTERDQRPMLIQTAAQYKFV
..     .||.|.. . .   .|||.| ..   .   .    ||| ||.||||.|.    |  ||. .    . . ... |. ||  |..  ... .
ieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlv....aaYLiyrl.gmsaeeAialfrekRpgaipnqdyleal

PTEN_1 540-598 3.9e-07 25.1 In-house 88-149 (196) alignment
Range on Protein: 540-598
Range on HMM: 88-149/196.0
EERIVLQMQ--YVAWPDHGVPDDSSDFLDFVLRVRQCRVGM-DVPTIVHCSAGIGRTGVLIT
||..  ...   . ..|||.|. |. |   .    ...        .||| ||.||.|... 
eeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 445-511 4e-07 23.7 In-house 227-290 (440) alignment
Range on Protein: 445-511
Range on HMM: 227-290/440.0
MDIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERgrvKCHKYWPDLDDRLKFGP
 .. |.   | ..|.| ||  || ||| .| . | . |.||    ..    |  |||     . |||
qefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgp

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 404-444 4.3e-06 20.5 In-house 33-75 (244) alignment
Range on Protein: 404-444
Range on HMM: 33-75/244.0
ACRLAENVAKNRYRDIAPYDATRVILREA--DTGDYINANTIN
 . |. |..|||| .| |.| |||||  .  .  |||||| |.
navlsanatknryinilpfdetrvilssskkegsdyinanyiq

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 436-557 4.7e-06 20.9 In-house 14-126 (130) alignment
Range on Protein: 436-557
Range on HMM: 14-126/130.0
DYINANTINMdipgFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTnVERGrvkcHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICN
.||||. . .     .  ..|. .| || .|  ||| |. |.   ..|.| . ||       .|||| .    .  |. |  |  ||        . | .
tyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrdefknikasnleies

TATKEERIVLQMQYVAWPDHGV
   .  . .  .|   ||  | 
dlneshqaltmfqisnwpsdgt