Gene PTPN5_RR in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN5_RR
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP062_AA protein Get Run
SpurP062_AA_0-198 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-200 3.8e-98 322.9 In-house 67-271 (274) alignment 
Range on Protein: 1-200
Range on HMM: 67-271/274.0
GYDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGF-----YGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHY
|||.| .|.||||||...|.|||||||. ....||||.||.||....||..|.|. ...     |||....||..| ..|| .. ..||||...|.| ||
GydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhy

WYTAWPDNKPPENPVTLLEMIREVEFSRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCL
|||.|||.| |... |||....||| || . . ...||.||||||.|||||.|||....||..||..||.|.|||..|.|||||.||.||||.||.||||
wytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

YEKCL
|.|.|
ylkrl
subfamily_PTPRD_pd Subfamily PTPRD 1-196 1.4e-76 253.4 In-house 86-280 (564) alignment 
Range on Protein: 1-196
Range on HMM: 86-280/564.0
GYDrEPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG-QGFYGDIDVTVEETVPKDDYILKIFTL--KYLNECRQVLHYWY
||. .. |..|||||.|.|..|||||.|  |  .|||.||..|... ||..|||.  .  ||.. ||.||.. . ||... |.|  |  .| |.| .. .
gyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhF

TAWPDNKPPENPVTLLEMIREVEFSRiDptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
|.|||.  ||.. .||..||.|. ..      .||..|||||| ||||..|.|   .... || .||| ..| ..|..|  |.||.||| |||.|.  .
tsWPdhgvpesatslLdlirkvraln.e..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
0050432 (Phosphotyrosine protein) phosphatases II 4-199 6.6e-69 227.9 In-house 105-301 (308) alignment 
Range on Protein: 4-199
Range on HMM: 105-301/308.0
REPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ----GQGFYGDIDVTVEETVPKDDYILKIFTLKY--LNECRQVLHYWY
. | .|.|||||. .|..|||||.|  | .||||.||. |..| ||. |||     |   ||.. ||. ..  .|||..  ..|..   .| |.| |..|
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

TAWPDNKPPENPVTLLEMIREVEFSRidptlPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYE
|.||| . |..|  ||.....|. |.     | ||..||||||.||||..||. | ..|...| .||....|...|. | ||.|| |||.|...||. | 
tnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

KC
|.
kl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-198 4.9e-68 224.5 In-house 84-281 (318) alignment 
Range on Protein: 1-198
Range on HMM: 84-281/318.0
GYDREpTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG-QGFYGDIDVTVEETVPKDDYILKIFTLKY--LNECRQVLHYWY
|| |.  |..|.|.|...|. |||||.|  |. ||||.|...|| . |.. |||.     ||.. |...|.|  .||.|. |...    .| |||  | |
Gyrrk.kayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhy

TAWPDNKPPENPVTLLEMIREVEfsRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYE
|.|||.  ||....||...|.|.  ... .  .||..|||||| |||| .||.   .... .|..||....| |.|. |  |.||..|||||...|  . 
tsWpdegvpesgaslldlvrqvs..kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal

K
.
a
subfamily_PTPRB_pd Subfamily PTPRB 5-194 2.6e-67 221.9 In-house 92-282 (293) alignment 
Range on Protein: 5-194
Range on HMM: 92-282/293.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG--QGFYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPD
 |  |.|||||. .|. |||||.| ... .|||.|.. |. . ||| |||.   . .|||| ||. ..  ..|.... ....  .|.|.| .| .|.|||
sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpd

NKPPENPVTLLEMIREVEfSRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
   ||.. |||...|.|. ..|. |  ..|..||||||.|||| .||.   .....|| .|||.|||...|..|  ..||..|| ||||.. 
hgvPektktlldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvl
0051299 (Phosphotyrosine protein) phosphatases II 5-196 4.3e-67 221.9 In-house 90-285 (288) alignment 
Range on Protein: 5-196
Range on HMM: 90-285/288.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLK------YLNECRQVLHYWY
 . .|.|||||. .|..|||||.|  | .||||.||. |..| ||. ||| .|   |||| ||  ... .|||..  ....      . .|.|.| |..|
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

TAWPDNKPPENPVTLLEMIREVEFSRIdptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
|.|||.  |..|  ||...|.|  ..     . |||.||||||.||||..||. | ..|...| .||.|..|...|. | ||.|| |||.|...||. |
tnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0046845 (Phosphotyrosine protein) phosphatases II 4-199 4.9e-67 221.6 In-house 74-276 (284) alignment 
Range on Protein: 4-199
Range on HMM: 74-276/284.0
REPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGqG---FYGDIDVTVEETVPKDDYILKIFTLKY---LNECRQVLHYWY
. . .|.|||||. .|..|||||.|  |..||||.|.. |..| ||. |||.  |    |||. ||. ..  ||||..  ..|..    .| |.| |..|
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

TAWPDNKPPENPVTLLEMIREVEFSRIDpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEES---MVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
|.|||.. |..|  |||..|.|. .. . . . ||..||||||.||||..||. | ..|...|.   .||.|..|...|. | ||.|| |||.|...||.
tswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeall

LYEKC
 | |.
eylkl
0036941 (Phosphotyrosine protein) phosphatases II 5-199 1e-64 214.1 In-house 76-279 (297) alignment 
Range on Protein: 5-199
Range on HMM: 76-279/297.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP---QGQGFYGDIDVTVEETVP--KDDYILKIFTLKY--LNECRQVLHYWY
 . .|.|||||. .|..|||||.|  | .||||.|.  |. | ||. |||   ..   |||. ||. ..    .|||.|  .....   .| |.| |..|
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhy

TAWPDNKPPENPVTLLEMIREVEFSRiDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMD---EESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
| |||...||.| .||..|..|.  . . . . |||.||||||.||.|..||. | ..|..   .|  |||| .|...|. | |..|| |||.|...|| 
tgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

LYEKC
 . |.
ellkk
0047943 (Phosphotyrosine protein) phosphatases II 5-196 2.3e-64 212.8 In-house 75-271 (273) alignment 
Range on Protein: 5-196
Range on HMM: 75-271/273.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG----FYGDIDVTVEETVPKDDYILKIFTLKY--LNECRQVLHYWYT
 . .|.|||||. .|..|||||.|  |..||||.|.. |..| ||. |||. .|     ||.. ||. ..  ||||..  ..|..   .|.|.| |..||
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhyt

AWPDNKPPENPVTLLEMIREVEFSRID---PtlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCL
 |||.. |...  |||.|..|.  .     .    |||.||||||.||||..||. | ..|. .| .||.| .|...|. | ||.|| |||.|...||. 
gwpdhgvppslesllefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

Y
|
y
0039614 (Phosphotyrosine protein) phosphatases II 1-199 4.9e-64 212.0 In-house 95-291 (297) alignment 
Range on Protein: 1-199
Range on HMM: 95-291/297.0
GYDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRsKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAW
|||. . .|.|||||. .|..|||||.|  . .||||.|| .|..| ||. |||. .| |||. ||. ..  .|.|..  ..... .| |.| |..|| |
gydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgw

PDNKPPENPVTLLEMIREVEFSRIDPtLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKC
||...|... .|||....|.  .     . |||.||||||.||||..||. | ..|...|  ||.| .|...|. |.|..|| .||.|...||. . |.
pdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 5-196 2.2e-62 206.4 In-house 86-276 (278) alignment 
Range on Protein: 5-196
Range on HMM: 86-276/278.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLK--YLNECRQVLHYWYTAWPD
 |..|.|||||. .|..|||||.|  . ..|||.|. .|..| ||  |||.|   |||. ||. ..  .|||..  ....  . .|.|.|.||.|..|||
vprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpd

NKPPENPVTLLEMIREVEFSRIdptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
.. ||.. .||.....|   .     . |||.||||||.||||..||. | ..|.. |  ||.. .|...|. |.|..|| .||.|...||. |
hgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0040438 (Phosphotyrosine protein) phosphatases II 5-199 3.2e-62 206.0 In-house 84-278 (317) alignment 
Range on Protein: 5-199
Range on HMM: 84-278/317.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLK--YLNECRQVLHYWYTAWP
....|.|||||. .|..|||||.|  .  ||||.|. .|..| ||. ||| ..   |||. ||. ... .....|  ....  . .|.|.| |..||.||
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

DNKPPENPVTLLEMIREVEFSRIdptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKC
| ..|..| .||.....|. ..     | |||.||||||.||||..||. | ..|...|  ||.  .|...|. |.|..|| |||.|...||. | |.
dhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
Y_phosphatase Protein-tyrosine phosphatase 3-193 5.6e-62 204.6 Pfam-A 39-233 (235) alignment 
Range on Protein: 3-193
Range on HMM: 39-233/235.0
DrEPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP---QGQGFYGDIDVTVE-ETV-PKDDYILKIFTLKYLNEC---RQVLH
. |. .|.|||||. .|..|||||.|  .  ||||.|. .|..| ||. |||   ...  |||| |... ..   ...|.|. ..||  .|    |.| .
k.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkq

YWYTAWPDNKPPENPVTLLEMIREVEFSRidpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
..||.|||.. ||.|  ||..||.|| |.   .  .|||.|||||| ||||...|. . ..|...|. ||.| ||...|. | ||.|. |||.|...|.
lhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 3-193 5.6e-62 204.6 In-house 39-233 (235) alignment 
Range on Protein: 3-193
Range on HMM: 39-233/235.0
DrEPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP---QGQGFYGDIDVTVE-ETV-PKDDYILKIFTLKYLNEC---RQVLH
. |. .|.|||||. .|..|||||.|  .  ||||.|. .|..| ||. |||   ...  |||| |... ..   ...|.|. ..||  .|    |.| .
k.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkq

YWYTAWPDNKPPENPVTLLEMIREVEFSRidpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
..||.|||.. ||.|  ||..||.|| |.   .  .|||.|||||| ||||...|. . ..|...|. ||.| ||...|. | ||.|. |||.|...|.
lhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-199 8.1e-62 204.1 In-house 89-285 (319) alignment 
Range on Protein: 5-199
Range on HMM: 89-285/319.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ-GFYGDIDVTVEETVPKDDYILKIFTLKYLN-EC--RQVLHYWYTAW
| ..|.|||.|...|. |||||.|  .. ..||.||..|. . |.. |||. .   || . ||.||   ..||| . ..|. .. |   |.| |. ||.|
erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteW

PDNKPPENPVTLLEMIREVEFSRIDPTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKC
||.. ||.  .||....... ||  ..   ||..|||||| |||| .|..   . .. ||...|.  .| ..|  |  |.|..|||.||..||  . ..
pdhdvPekatslldllkrirksrektq..sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0045450 (Phosphotyrosine protein) phosphatases II 5-196 2.1e-61 203.7 In-house 105-303 (307) alignment 
Range on Protein: 5-196
Range on HMM: 105-303/307.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG--QGFYGDIDVTVEETVPKDDYILKIFTLK---YLNECRQVLHYWYTA
 ...|.|||||. .|..|||||.|  .  ||||.|. .|..| || .|||.   .  ||.. ||. ..  .|.|..  ....   . .| |.| |..||.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDNKPPENPVTLLEMIREVEFSRIDpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESM---VDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
||| . |... .||..|.||.  . . . . |||.||||||.||||..||. | .||...| .   ||.| .|...|. |.|..|. |||.|...||. .
wpdhgvppsfeelldfieevrkalee.lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
DSPc_SM00195 5-196 1.3e-60 200.3 In-house 67-261 (263) alignment 
Range on Protein: 5-196
Range on HMM: 67-261/263.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG---QGFYGDIDVTVEETVPKD-DYILKIFTLKYLN--ECRQVLHYWYT
.. ...|||||. .|..|||||.| .. ..|||.|. .|... ||. |||.    .  .|.| |.. |.  |. ..||. ..|.. .  | |.| .|.|.
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyk

AWPDNKPPENPVTLLEMIREVEFSRIDPtlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
.|||.. |...  .||..|.|. |.       ||..||||||.||||....| . .....||..|||  ||...|. | ||.|| ||| ||..|.  |
nWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 5-196 1.3e-60 200.3 In-house 67-261 (263) alignment 
Range on Protein: 5-196
Range on HMM: 67-261/263.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG---QGFYGDIDVTVEETVPKD-DYILKIFTLKYLN--ECRQVLHYWYT
.. ...|||||. .|..|||||.| .. ..|||.|. .|... ||. |||.    .  .|.| |.. |.  |. ..||. ..|.. .  | |.| .|.|.
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyk

AWPDNKPPENPVTLLEMIREVEFSRIDPtlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
.|||.. |...  .||..|.|. |.       ||..||||||.||||....| . .....||..|||  ||...|. | ||.|| ||| ||..|.  |
nWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0045098 (Phosphotyrosine protein) phosphatases II 6-200 4.8e-60 198.6 In-house 63-275 (278) alignment 
Range on Protein: 6-200
Range on HMM: 63-275/278.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ-GFYGDIDVTVEETVPKDDYILKIFTLK------YLNECRQVLHYWYT
|..|.|||||. .|.||||||.|  . .||||.|. .|..| ||..||| |.   |||. ||....   |||.|  ...       . .|.| | |..|.
pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhyl

AWPDNKPPENP--VTLLEMIREVEFSRI--------------DPtlprGPVIVHCSAGLGRTGCYIAITLGMRQMdeESMVDILGIVCQIRQDRGG-MIQ
 |||. .|..|    .||......  .               ..    |||.||||||.||||...|. | ....  |. ||.| .|...|. |.| ..|
pwpdhgvpslpilksflellefirealkllaslllsslllldsg....gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavq

TNEQYEFIHQALCLYEKCL
. |||.|....|... ...
nleqyrflyefllelllrg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-198 7.1e-60 197.3 In-house 58-265 (270) alignment 
Range on Protein: 1-198
Range on HMM: 58-265/270.0
GYDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGF-----YGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHY
|.| |.....|..||.. || .|||||| .... |||.|...|. |.|||.|||. ..      .|.| |...... .. |||.  .|..  | |...|.
GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHf

WYTAWPDNKPPENPV------TLLEMIREVEFSRIDPTLPRgPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFI
||..|||.  |...        ||.|.|.|  |. .      |..||||||.||||. ||.  ..| ..|.. ||.| |. ..|.||  ..|. |||||.
wyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl

HQALCLYEK
..|. .| .
ykavveyae
subfamily_PTPRK_pd Subfamily PTPRK 4-200 1e-58 193.7 In-house 83-278 (314) alignment 
Range on Protein: 4-200
Range on HMM: 83-278/314.0
REPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLKY----LNECRQVLHYWYTA
. |.||..||||. .|..||||...  |.  |||.|...|  | ||  |||.    ||||.|.. || .. ... .||...      .| |.| .. ...
krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflg

WPDNKPPENPVTLLEMIREVEFSRIDptlPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALclYEKC
||| . | .  .||...|.|. |. .     |...|||||| ||||..|||.  .  ...|..||.  .| ..|. .  |..|.||| ||....   | |
WpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi..leac

L
|
l
0040439 (Phosphotyrosine protein) phosphatases II 5-196 2.8e-58 192.8 In-house 52-245 (249) alignment 
Range on Protein: 5-196
Range on HMM: 52-245/249.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLK--YLNECRQVLHYWYTAWP
 ...|.|||||. .|..|||||.|  .  ||||.|. .|..| ||. ||| .|   |||. ||. ..  ||||..  ..|.  | .| |.|||..|| ||
ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp

DNKPPENPVTLLEMIREVEFSR--IdptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
| . |... .||..|..|.  .  .    . |||.||||||.||||..||. | ..|...|  ||.. .|...|. |.|..|. |||.|...||. .
dhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 6-194 4.4e-58 191.6 In-house 89-276 (288) alignment 
Range on Protein: 6-194
Range on HMM: 89-276/288.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG--FYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPDN
  ...|||||.|.|. |||.... ...  |||.|.. |. ..||| |||...    ||...||. |.  ..|..|. . |.  .. ... .| |.||||.
kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdh

KPPENPVTLLEMIREVEFSRIDPtlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
. ||.   |||..| |. .  .     ||.|||||||.|||| .||.   . ...|| ..|..|.|...|. |  ..|| .|||||...| 
gvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-199 1.8e-57 189.8 In-house 85-285 (305) alignment 
Range on Protein: 2-199
Range on HMM: 85-285/305.0
YDREpTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGF---YGDIDVTVEETVPKDDYILKIFTLKY---LNECRQVLHY
|.|.  .....|||. .|.|||||.|. .   .|||.||..| ...||..|||. ..    .|.. |.....    ||| . ...      .| |.||.|
ykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqy

WYTAWPDNKPPENPVTLLEMIREVEFSRidpTLPRG-PVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
  | |||.  |. . .||..|..|. ..      .| |..||||||.|||| .||. . . .. .| .||. ... |.|. | .|.|| .|| |.|.|| 
qltdWPdhGvpqfatsllslikrvqkdq...kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdald

LYEKC
.. .|
elitc
0042113 (Phosphotyrosine protein) phosphatases II 6-196 2.2e-57 189.6 In-house 51-242 (245) alignment 
Range on Protein: 6-196
Range on HMM: 51-242/245.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLK--YLNECRQVLHYWYTAWPD
.  | |||||...|..|||||.|  .  .|||.|.  |..| ||. ||| ..   |||. ||. ..  .|||.. .....  . .| |.|.||.|. |||
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

NKPPENPVTLLEMIREVEFSRIDptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
...|... .||.....|.  . .   . |||.||||||.||||..||. | ..|...|  |..  .| ..|. |.|..|| .||.|...||. .
hgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 5-194 1.1e-56 186.9 In-house 81-274 (290) alignment 
Range on Protein: 5-194
Range on HMM: 81-274/290.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ--GF-YGDIDVTVE-ETVPKDDYILKIFTLKYLNECRQVLHYWYTAW
......|.|||...|| ||||||| .|  ..||. .. | .. ||| |||. .     .|.. ||.| |   .||.... ....  .|.|.|  . ||||
gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaW

PDNKPPENPVTLLEMIREVEFSRIdptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESM---VDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
||   |... .|||.|..|.  .        |..|||||| ||||  ||| .  ... .| .   .|.  .| ..|..|  ..||.||||....|. 
PDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykava
0037934 (Phosphotyrosine protein) phosphatases II 9-196 1.2e-56 187.4 In-house 46-241 (243) alignment 
Range on Protein: 9-196
Range on HMM: 46-241/243.0
FVATQGPMAHTLAD----FWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPqGQGFYGDIDVTVEETVPKDDYILKIFTLKY---LNECRQVLHYWYTAWP
. |||||. .|..|    ||||.|  .  ||||.|. .|..| ||..||| |.  |||. ||. ..  .|||..  ..|..    ...|.| ||.|..||
liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DNKPPENPVTLLEMIREVEFSRID-----PTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMdeeSmVDILGIVCQIRQDRGG-MIQTNEQYEFIHQALCL
|...|..|  ||....||     .        . |||.||||||.||||..||. | ....   . ||.. .|...|. |.| ..|| .||.|...||. 
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

Y
.
l
subfamily_PTPRA_pd Subfamily PTPRA 4-196 1.3e-56 186.8 In-house 98-294 (330) alignment 
Range on Protein: 4-196
Range on HMM: 98-294/330.0
REPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLKY------LNECRQVLHYW
.|   |.|.||| ..|. |||||||  ..  |||.|..||||..||. ||| .|   ||.| |.||...   || .. | ..        .. |.|  . 
kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfh

YTAWPDNKPPENPVTLLEMIREVEfsRIDPTLPRgPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
.|.|||   | .|. .|.....|.  ....     |..|||||| |||| .|..   . ..  | .||. ..| ..|. |  |.||.||||||...|  |
ftswPdvGvPfepiGmlkllkkvk..klnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRG_pd Subfamily PTPRG 1-194 1.6e-56 186.7 In-house 86-284 (563) alignment 
Range on Protein: 1-194
Range on HMM: 86-284/563.0
GYDREpTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ-GFYGDIDVTVEETVPKDDYILKIFTLKY-----L---NECRQ
|| ..  ||.|||||...|. |||||||  |. .|||.|...||.| ||..|||. .   || . || .|.  .  |  . ...|          .. ..
Gyqks.kafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdtekl

VLHYWYTAWPDNKPPENPVTLLEMIREVEFSRIDPTlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQ
| .| || |||   || ..  | ...  . .. . .   ||..|||||| |||| ||...  ..|. .|..|...|.. .||  |  ..||.||| |.|.
vrqyhytkWPdhgvPehslpvLifvkkssaankaea...GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd

ALC
|| 
all
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-199 1.6e-56 186.8 In-house 96-292 (298) alignment 
Range on Protein: 3-199
Range on HMM: 96-292/298.0
DREPtAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ-GQGFYGDIDVTVEETVPKDDYILKIFTLKYLN--ECRQVLHYWYTA
.... ||.|||.|. .|..|||||..  .. .|||.|...| .. |.. |||. |.  ||.|.|.. ..  . |.| . ....  .  . |.| .  .| 
kgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhfts

WPDNKPPENPVTLLEMIREVEFSRIDptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKC
|||.  |||  ..|...|.|. |. .      ||||.|||| ||.| .|||   . .. .|..||.. .|  .|..| |..||.||| ||..|   . ..
Wpdkgvpenatsvldllrkvrasqqq..agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_PTPN6_pd Subfamily PTPN6 7-199 7.2e-56 184.4 In-house 98-299 (306) alignment 
Range on Protein: 7-199
Range on HMM: 98-299/306.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG--QGFYGDIDVTVEETVPKDDYILKIFTL---KYLNECRQVLHYWYTAWP
....|||| . .|..|||||.|  |. ||||.||  || ..||  |||.   .  ||.| ||  .   ..||||. ...   |  .|.|.| .| ...||
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWP

DNKPPENPVTLLEMIREVEFSRIDPT-LPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEE---SMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYE
|.  |..| ..|.....|.  . . .    ||..||||||.|||| .| | . .... ..     .||  .| ..|. | |..||..|| |...|.  | 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

KC
. 
et
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-199 3.9e-55 181.8 In-house 48-244 (250) alignment 
Range on Protein: 2-199
Range on HMM: 48-244/250.0
YDREpTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSkCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLKYLNECRQ--VLHYWYT
|| .  ||.|||||. .|. |||||..  .. .|||.|..|| ..  .. ||| ..   |||. |.. ..  . ||. . . |   ..  .  | .. ..
yder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfv

AWPDNKPPENPVTLLEMIREVEFSriDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEK
.|||   ||.  . ||....|. |  ..    .||||.|||| ||.|..|||   . .. .| .||.  .. ..|.|| ......||| |.....  . .
vWPdkgvPevatavLellkkvqas..qqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

C
.
s
subfamily_Ptp69D_pd Subfamily Ptp69D 5-197 2.4e-54 179.6 In-house 89-286 (307) alignment 
Range on Protein: 5-197
Range on HMM: 89-286/307.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWP-QGQGFYGDIDVTVEETVPKDDYILKIFTLKYLN-------ECRQVLHYW
|   |.| |.|.  |. ||||||.  .  .|||.....| .| ||. ||| . .  |||| |.. ..  ..||| . . .   .       . |.|. | 
ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyh

YTAWPDNKPPENPVTLLEMIREV-EFSRIDptlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCL
||.|.| | || . .||..|..| |  . .    |.|..|||||| ||.| ..|... . |. .|  |||  .|...|..|  ..|  |||.|...||  
ytgWkDskvPevargllklieqvrelykln....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld

YE
|.
ys
subfamily_PTPN9_pd Subfamily PTPN9 4-197 1.6e-52 173.4 In-house 82-290 (297) alignment 
Range on Protein: 4-197
Range on HMM: 82-290/297.0
REPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ---GFYGDIDVTVEETVPKDDYILKIFTLK--YLNECRQVLHYWYT
... ||.|||||. .|  |||||.|  .. ||||.|.. ||.| ||  |||...     .||. |.. |.. ..||  .....|    .| |.| |. ..
kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqfl

AWPDNKPPENPVTLLEMIREVEF---------SRIDPTLPR-GPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEF
.|||   |..  .||.....|           .  .   |.  |..||||||.|||| .|.. . . ...|...||.   | ..|. |  .|||.|||||
sWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef

IHQALCLYE
 ..|.  | 
cylavleya
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 5-194 2.2e-52 172.9 In-house 82-273 (281) alignment 
Range on Protein: 5-194
Range on HMM: 82-273/281.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ--GFYGDIDVTVEETVPKDDYILKIFTL-KYLNECRQVLHYWYTAWP
......|||||. ..|..||.|.| ... .|||||.  |  . ||  |||...    |||. |. ...  |  || . |.| .  .| |.| .  |||||
gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWP

DNKPPENPVTLLEMIREV-EFSRIDPTlprGPVIVHCSAGLGRTGCYIAITLGMRQMDE-ESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
|.  |...  |||  .|| .... .      |...||||| ||||.|||.   ...... ....|.  .| ..|..|  |.||  ||||...|. 
dhGvPattkellefrkevlkltekktk...aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_PTPN3_pd Subfamily PTPN3 9-196 6.6e-51 167.9 In-house 86-275 (280) alignment 
Range on Protein: 9-196
Range on HMM: 86-275/280.0
FVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG--FYGDIDVTVEETVPKDDYILKIFTLKYLN--ECRQVLHYWYTAWPDNK
..|||||.|.| .|||.|.|  .. .|||.| . || | ||  |||. .    ||...|..|..  .  |.|. ..||  .  | |..|.  |.||||..
yiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhg

PPENPVTLLEMIREVEFSRidpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC-LY
 |...  .||....|.  |   .  . ||.||||||.|||| .|.. . .  ....  | .| || ..|. |. ..||..||.|. .|.. .|
vPddsadflefvervrklr...sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-198 3.1e-50 165.7 In-house 89-284 (290) alignment 
Range on Protein: 5-198
Range on HMM: 89-284/290.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG-QGFYGDIDVTVEETVPKDDYILKIFTLKYLNE---CRQVLHYWYTAW
|  ...|||||. .||.|||..||  . ..|||.|.|.| .. ||  |||.  .  || . ... .    ..|| . . .|  |.   ...| .|  |.|
ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnw

PDNKPPENPVTLLEMIREVEFSRIDPTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEK
...   .|| | | .|.|..  .  ..  .....||||...||.. ..|.. .. ..  |  .|.. .. . |. . |..||..||..|.| .  | .
dstgkvtnpqtillvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 5-193 8e-49 161.2 In-house 90-275 (315) alignment 
Range on Protein: 5-193
Range on HMM: 90-275/315.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPDNK
 .  ..|.||| . .. ||||...  .   |||.|.. |....|.| |||  .  || | ||  .   ...|  . ..  . .. |.|. . ||.||| .
kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmg

PPENPVTLLEMIREVEFSRIDPTlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
 |.  ..|...|| |   . .     |...|||||| |||| .|..   . |.. | ..|.  .. ..|| | .|.|. |||.||..||
vpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-194 4e-48 159.4 In-house 99-288 (319) alignment 
Range on Protein: 1-194
Range on HMM: 99-288/319.0
GYDRePTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTkikerkRSKCEMYWPQ-GQGFYGDIDVTVEETVPKDDYILKIFTLKY---LNECRQVLHYW
|| | .  ..|.|||.  ||||||||||  |.  ||..|      . ||  |||. ..  ..  .| |.     ..|... . |      .. |..  . 
Gyqr.kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfh

YTAWPDNKPPENPVTLLEMIREVEFSRIDpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
.  |||   |. |. |. ... |.  .      | ...|||||| |||| ||..   . .|.||..||.  .| ..||.|  ..|   || ||. || 
flGwpdvGvpdypsdlmrlvkkvrhltsk.enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 7-193 9.5e-48 157.5 In-house 86-272 (515) alignment 
Range on Protein: 7-193
Range on HMM: 86-272/515.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ--GQG-FYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPDN
 |..|.|||   .. ||||...  |   |.|||| ||  ..||  |||.  |.   .| | | .  .    . | . .|.   ...| |  . .| |||.
kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdk

KPPENPVTLLEMIREVEFSRIDPTlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
  |..  .|| .|.||  ..   |    |.|.||||| |||| .|.|   . .. .  |||.. .| .|||.|  ..||.||| ||..|.
Gvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-194 1.4e-47 157.6 In-house 63-252 (284) alignment 
Range on Protein: 1-194
Range on HMM: 63-252/284.0
GYDRePTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTkikerkRSKCEMYWPQ-GQGFYGDIDVTVEETVPKDDYILKIFTLKY---LNECRQVLHYW
|| | .  ..|||||.  ||||||||||  |.  ||..|      . ||  |||. ..  ..  .| |.     ..|... . |      .. |..  . 
Gyqr.kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfh

YTAWPDNKPPENPVTLLEMIREVEFSRIDpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
.  |||   |. |. |. ... |.  .      | ...|||||| |||| ||..   . .|.||..||.  .| ..||.|  ..|   || ||. || 
flgwpdvgvpdypsdlmrlvkkvrhltsk.enhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-199 1.8e-47 156.7 In-house 84-280 (287) alignment 
Range on Protein: 5-199
Range on HMM: 84-280/287.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ-GFYGDIDVTVEETVPKDDYILKIFTLKYLN---ECRQVLHYWYTAW
|  ||.....||..|. .||..|.  | ..|||... || ....|  |||...   .|.  ... .   ...|| . . .|  |   . .||  | .|.|
ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnW

PDNKPPENPVTLLEMIREVEFSRIDPTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKC
...   ..| | | .| |   ..  ..  .....||||.. ||.. ..|.  .... ..|  .|.. .. . |. . |..|| |||.|| ...  | ..
dstgkvtepqtillvieemyktqrkrg..ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN13_pd Subfamily PTPN13 7-193 4.1e-47 155.7 In-house 77-265 (273) alignment 
Range on Protein: 7-193
Range on HMM: 77-265/273.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG----FYGDIDVTVEETVPKDDYILKIFTLKYL--NECRQVLHYWYTAW
  ..|.|||. .| .|||.|.|  .| ||.|||. ||... ||. |||. ..     .. ..|...... .|.. .. ...| .  .| |.| |  ...|
yeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkw

PDNKPPENPVTLLEMIREVEfsRIDPtlPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
|| . | ... ||....||   |..    .||..||||||.||.| .|.|   .  .. .  .|.  || ..|. | |..||..|| |...|.
PdhgvPssaaellqfvaevr..rlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 7-194 1.7e-46 153.5 In-house 87-274 (315) alignment 
Range on Protein: 7-194
Range on HMM: 87-274/315.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ--G-QGFYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPDN
 |..|.|||   .. |||||.. ...  |||||| .|  . ||  |||.  .    .| | |.. .. .  | . . ....  .| |.|  . .| |||.
kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdk

KPPENPVTLLEMIREVEFSRIDPTLprgPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
  ...  .||..|.||  ..   .    ...|||||| ||||  |.|   . |. ....||.. .| ..|..|  ..||.|.| ||..|. 
Gvdkqtssllklikevkadngkkef...sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl
0051429 (Phosphotyrosine protein) phosphatases II 6-196 3.6e-46 153.3 In-house 21-224 (272) alignment 
Range on Protein: 6-196
Range on HMM: 21-224/272.0
PTAFVATQGPMAHTLADFWRMiWFTNAPVIVMVTKIKERKRSKCEMYWP-------------QGQGFYGDIDVTVEETVPKDDYILKIFTLK---YLNEC
| .. ...||. .| |||||. .  .  .||....  ||.| ||..|||               . .||.. ||. ... ..||||  ..|.   . .| 
pgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

RQVLHYWYTAWPDNKPP-ENPVTLLEMIREvefsridptlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVD--------ILGIVCQIRQDRGGMI
|.|.|..||.|||   | |  ..|||....            |||.|||||| .|||...|. | ......| .||        ....| ..|. | |..
revmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgav

QTNEQYEFIHQALCLY
|| |||.|...||  .
qteeqylflyeallel
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 6-193 4e-46 152.2 In-house 74-262 (283) alignment 
Range on Protein: 6-193
Range on HMM: 74-262/283.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ-GQGFYGDIDVTVEETVPKDDYILKIFTLKYLNECR---QVLHYWYTAWP
   ....|.|. .|  |||.|..  ..  |||.||..| .| ||  |||. |   ||.  ||... . .. .| | ..|.. . ..    . || .  | 
dkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWl

DNKpPENPVTLLEMIREVEfsRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
.   .. ..  |  .  |         ..||..||||.| |||. .||..  . ..  ||.||.  .|  .|..| ...|| .|| ..|.. 
eyg.eqaiinslvkfnkvi..slqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 8-193 3.2e-45 149.5 In-house 93-280 (297) alignment 
Range on Protein: 8-193
Range on HMM: 93-280/297.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRsKCEMYWPQ-GQGFYGDIDVTVEETVPKDDYILKIFTLKYLN-ECRQ-VLHYWYTAWPDNK
 ...|| ||  |.||||.|..  .. .|||... .||.. ||  ||.. |   .||. |... .  .  .| . ....  .   |. |  | .. |||..
rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdka

PPE--NPVTLLEMIREVEFSRIdpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
 ..  .  .||..| ||. .    .   ||..|||.||.|||| ...|   . .. .|  |||.|.| ..||.|  ..||.|||.|...|.
verkdsassllklisevrkdfs..qnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-193 5.9e-45 148.3 In-house 46-236 (239) alignment 
Range on Protein: 2-193
Range on HMM: 46-236/239.0
YDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLKYL--NECRQVLHYWYTA
||  | |..|||| .. .  |||||.|     ||||.| . | .. ||  |||.    | .. ||. .|    |||.. | .  .   | | | .| .| 
ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftv

WPDNKPPENPVTLLEMIREVEFSRIDPtlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
|||.  |.   ..| . |..    .       | ..|||||.||||... |   .||  ..  |||.  |  ||.||  |.||.||| ||| |.
wpdkgvpqyatavlglrrkitkdslpg...arpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-193 6.3e-45 148.2 In-house 47-237 (239) alignment 
Range on Protein: 2-193
Range on HMM: 47-237/239.0
YDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLKYL--NECRQVLHYWYTA
||  | |..|||| .. .  |||||.|     ||||.| . | .. ||  |||.    | .. ||. .|    |||.. | .  .   | | | .| .| 
ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftv

WPDNKPPENPVTLLEMIREVEFSRIDPtlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
|||.  |.   ..| . |..    .       | ..|||||.||||... |   .||  ..  |||.  |  ||.||  |.||.||| ||| |.
wpdkgvpqyatavlglrrkitkdslpg...arpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN23_pd Subfamily PTPN23 8-194 1.1e-44 147.4 In-house 84-278 (288) alignment 
Range on Protein: 8-194
Range on HMM: 84-278/288.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG---FYGDIDVTVEETVPKDDYILKIFTLKYLN--ECRQVLHYWYTAWPD
 |.|||.|.. ||.|||.|..   ..||||... .|... |.. |||. .|    .||..||....   . .. ....|. |.  . ..| |  .|.||.
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

NKPPENPVTLLEMIREVEF-SRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDE-ESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL-C
   |. | |||... |||   .      . |..|||||| |||| .  .   .|.... . ..||. .| ..|..|  |.|..||..|  .|  .
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 7-195 2.4e-44 146.8 In-house 91-286 (325) alignment 
Range on Protein: 7-195
Range on HMM: 91-286/325.0
TAFVATQGPMAHTLADFWRMI--WFtnAPVIVMVTKIkERKRSKCEMYWPQG---QGFYGDIDVTVEETVPKDDYILKIFTLKYLNEC--RQVLHYWYTA
  |.|.| |...|. |.||..  |   ..|.|.. .. . .  .| .|||.       .| ..| .       ||. ... .|  ..   | |  . . .
dvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqs

WPDNKPPENPVTLLEMIREVEF--SRIDP-TLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCL
|.|   .. | ||. ... |.    |.   |   .|..||||||.|||| .|..   . .. ||| |||.| | ..|.||  |..| .|| .|..||  
wddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_PTPRN_pd Subfamily PTPRN 6-193 2.6e-43 142.8 In-house 99-288 (297) alignment 
Range on Protein: 6-193
Range on HMM: 99-288/297.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ-GQGFYGDIDVT-VEETVPKDDYILKIFTLKYL--NECRQVLHYWYTAWP
 .|..|||||.|.|.||||.|.|   . |||..|...|   ..|. |||. |.  |.  .|  | | .  |||... | || |  .| | |  . . .||
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp

DNKPPENPVTLLEMIREVEFSRIDptlPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEE-SMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
..  | .. .|||. | |. |         |..||||.| ||||.||.| | . ..      .||   .  .|..| |...|..|.||. .|.
eegvPasaksllefrrkvnksyrG...rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 5-196 5.8e-43 141.7 In-house 83-292 (301) alignment 
Range on Protein: 5-196
Range on HMM: 83-292/301.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG---FYGDIDVTVEETVPK-----------------DDYILKIFTLK
| ..|.|.|||| .||.||||.||      |||||. ||...|||| |||...     .| . ||. ..                    . || . |  |
ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvk

YLNECRQVLHYWYTAWPDNKPPENPVTLLEMIREVEFSRIDptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNE
  .. ..|| .  | ||..    .| | |. | .|   .       |||.||||.. .|.| |.....|. |   |  ||. ...  .|. . |...| |
sdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk..igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLe

QYEFIHQALCLY
|| .|....  |
qytsiydvidmy
subfamily_PTPN1_pd Subfamily PTPN1 8-200 7.9e-43 141.2 In-house 72-274 (290) alignment 
Range on Protein: 8-200
Range on HMM: 72-274/290.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG----FYGDIDVTVE--ETVPKDDYILKIFTLKY--LNECRQVLHYWYTA
 .. ||||...| . ||.|.|  ..  .||. |. |... ||  |||||.      . |. ..|.  ..  |. |..... |.    .|.|..||. ||.
syiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhytt

WPDNKPPENPVTLLEMIREVEFSRIDpTLPRGPVIVHCSAGLGRTGCYIAITL---GMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
|||   || | ..|... .|  |    .   ||...|||||.||.| .. .      . . |. | |||   ....|. | |.||| .| .| ..|.   
wpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

EKCL
 |..
akvi
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-193 2e-42 140.0 In-house 39-235 (237) alignment 
Range on Protein: 1-193
Range on HMM: 39-235/237.0
GYDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ--GFYGDIDVTVEETVPKDDYILKIFTLKY---LNECRQVLHY
|.|  |  ..|.|||.  .  |||.|.|  .  ||||.| . |... ||  |||. .    || . |..       || .. ..| .   |.| | .  |
gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqy

WYTAWPDNKPPENPVTLLEMIREVeFSRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
 .|.|||.  |..  .|| . ...   |       || |.|||||.|||| .. |   .||  |. .|||   |  | .||  .|||..|| ||||..
qftswpdrgvpqqtaallrfrkni.inrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0036282 (Phosphotyrosine protein) phosphatases II 6-191 1.4e-41 137.5 In-house 16-164 (174) alignment 
Range on Protein: 6-191
Range on HMM: 16-164/174.0
PTAFVATQGPMAhtladFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQgqgfygdidvtveetvpkddyilkiftlKYLNECRQVLHYWYTAWPDNKP
.. ..|.|||.|     ||.|..  .  ..||... ||... ||  |||                             ..  . | ...|.|. |||. .
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredlerlgiqylylpwpDhgv

PENPVtLLEMIREVEFSRIDptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDeESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQ
|. .. |||....||  . .   | |||.||||||.||||. .|. | .|..  ||.||.| .| ..|. |.||.|| .||.|...
pdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN14_pd Subfamily PTPN14 8-196 7.5e-41 135.1 In-house 94-295 (300) alignment 
Range on Protein: 8-196
Range on HMM: 94-295/300.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG-----QGFYGDIDVTVEETVPKDDYILKIFTLKYLN--ECRQVLHYWYTAW
 ....|||. .|. |||.|.| ..  .|||.|...|  . |.  |.|.      .  .|   || . .   | .| . ..||.|   | |.|.|  || |
syivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDW

PDNKPPENPVTLLEMIREVEFSRI------DPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
||.. ||.. . |. ..||.  |       ...  . ||.|||||| ||||  |   | .  .. .  .||  .. ..|. |  ..||  ||.|....| 
pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

LY
 |
ky
0041856 (Phosphotyrosine protein) phosphatases II 5-198 2.2e-40 133.5 In-house 32-172 (182) alignment 
Range on Protein: 5-198
Range on HMM: 32-172/182.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTkikerkrskCEMYWPQGQgfygdidvtveetvpkddyilkiftlkylneCRQVLHYWYTAWPDNK
 .| |.|||||. .|.|||.||..  .  .||..|         .|.|||.                                  |....|.|. |||. 
patrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell...............................erlgiqylylpwpDhg

PPEnPVTLLEMIREVEFsridptlPRGPVIVHCSAGLGRTGCYIAITLGMRQmdeesMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEK
.|. . .||..|.||.        . |||.||||||.||||...|. | ...      |..  .|...|. | ||..| .|| |...||... .
vpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 5-193 1.3e-39 130.9 In-house 89-275 (439) alignment 
Range on Protein: 5-193
Range on HMM: 89-275/439.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRskcemYWPQ-GQGFYGDIDVTVEETVPKDDYILKIFTL---K-YLNECRQVLHYWYTA
..  ..|||||  .|  ||||...  ..  |||.|.. |  .     |||  .. .|||| | |.  .   .|... | .   .   .  | ||.. |.|
ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyia

WPDNKPPENPVTLLEMIREVEFSRiDpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
|||.. | .   .|...| .. .  | .   |||.||||||.||||  ||. . . |.  |  ||| |||  .|..|  |.|.  || ||..|.
wpdknvpaqashvldflrainsan.d.keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0049260 (Phosphotyrosine protein) phosphatases II 6-191 3.3e-38 126.1 In-house 8-144 (152) alignment 
Range on Protein: 6-191
Range on HMM: 8-144/152.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWpqgqgfygdidvtveetvpkddyilkiftlkylnecrqvlHYWYTAWPDNKP
|..|.|||||. .||||||||..  .. .|||.|.  |... |||.|.                                        .| .. |||. .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhgv

PENPVTLLEMIREVEFSridPTLPRGPVIVHCSAGLGRTGCYIAITLGMrqmdeeSMVDILGIVCQIRQDRGGMIQTNEQYEFIHQ
|...  ||.... .|.       . |||.||||||.||||...|. | .        |... .| ..|. | |.... .|..|...
pdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 8-197 1.1e-37 124.8 In-house 24-173 (176) alignment 
Range on Protein: 8-197
Range on HMM: 24-173/176.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGdidvtveetvpkddyilkiftlkylnecrqvlHYWYTAWPDNKPPE
...|||||. .|||||..|..  .  ..|..|. .| .| ||  |||. ...                                  .|... |||. .|.
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................................qylhlpwpDhgvpd

NpVTLLEMIREVEFSRIDPtlprGPVIVHCSAGLGRTGCYIAITLGMRqmdeESMVDILGIVCQIRQDRG-GMIQTNEQYEFIHQALCLYE
    |||......  . .     |||.||||||.||||...|. | ..    |  .... .....|. |  |..|| |||.|......|. 
l.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 6-191 2e-37 123.9 In-house 19-155 (172) alignment 
Range on Protein: 6-191
Range on HMM: 19-155/172.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIkerkrskcemywpqgqgfygdidvtveetvpkddyilkifTLKYLNECRQVLHYWYTAWPDNKP
|. |.|||||. .||||||||..  .  .||..|.                                         .. . ...|....|.|. |||. .
pdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpellerlgiqylylpwpDhgv

PeNPVTLLEMIREVEFSRidPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMdeesmvDILGIVCQIRQDRGGMIQTNEQYEFIHQ
| ..  |||... ..        | |||.||||||.||||. .|. | ....      ... .|...|. |.|..|. .|| |...
p.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrflyy
subfamily_CG7180_pd Subfamily CG7180 6-194 3.2e-36 119.5 In-house 84-287 (296) alignment 
Range on Protein: 6-194
Range on HMM: 84-287/296.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRsKCEMYWPQG-QGFYGDIDVTVEETVPKDDYILKIFTLK------------YLNECRQV
. ... |..|. .|. .|||...  ..  .|..||  . .. ..  |||.  .  ||.| | . |.    .   . | |.               | | |
kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRiv

LHYWYTAWPD-NKPPENPVTLLEMIREVEF--SRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFI
... .| |.  .| |    .|.|..| |.    ..|    .|||.|..| | .|.| |.||   . ....|  ||. . | ..|..| ..... |.| .|
klfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyi

HQALC
 . | 
Ydvll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 8-196 3e-35 116.3 In-house 95-282 (290) alignment 
Range on Protein: 8-196
Range on HMM: 95-282/290.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG---FYGDIDVTVEETVPKD-DYILKIFTLKYLNECR--QVLHYWYTAWP
 |. |||... |  |.|||.  ... .|||. .. |  ..||| |.|. .|    .|.| |.  |   || . |.|.....  .. .  .. |.   .||
mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp

DNKPPENPVTLLEMIREVEfsrIDPtlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
|.  .   ..|| ..| .      .    |||.||||||.|||| ..||  |.. . .   .|.|..|  .|. | . .| . ||  . ..|  .
dksvalstlallrtlrilr...kas....GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-201 6.1e-35 115.4 In-house 76-281 (287) alignment 
Range on Protein: 2-201
Range on HMM: 76-281/287.0
YDREpTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG--FYGDIDV-TVEETVPKDDYILKIFTLKYLNE--CRQVLHYW
| ..  ||.|.|||.| |. ||||... |.. .....|.  |  | ||  |||. .     |   |  .. .. . .|  . . |  |.   .| |  . 
ytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqld

YTAWPDNKPPENPVTLLEMIREV----EFSRIdpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQA
. .|||.  .   | |. .. .|    | .|   .   ||..||...|.||.| ..|.   .... .   ||.  .| ..|. | ...|.  |. .. .|
llswPdkvlaPtavglirfvldvkqhielard..asevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyea

LCLYEKCLP
|  | |  |
lvtyyktnp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 7-193 6.5e-35 115.3 In-house 88-232 (392) alignment 
Range on Protein: 7-193
Range on HMM: 88-232/392.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKrskcemywpqgqgfygdidvtveetvpkddyilkiftlkYLNECRQVLHYWYTAWPDNKPP
 |..|.||| | .| |||||..  |.  |.||||.||                                           ...| |  . .| |||.  |
kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......................................kgddartvaqfhftewPdkdvp

ENPVTLLEMIREVEFSRIDPTlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
.   .||..|.||.    . |    |.|.|||||.||||  |.|   . .  .  |||.. .| .||. |  |.||.||| ||. |.
khtssllkfikevkadfGqyt...hpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 8-191 1.6e-33 110.5 In-house 6-198 (199) alignment 
Range on Protein: 8-191
Range on HMM: 6-198/199.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ---GQGFYGDIDVTVEETVPKDDYILKIFTLKY----LNECRQVLHYWYTAW
 ..||| |. .|.||||.|.| | .  ||||   .  | .   .|||    | | || . ||..  . | || .  . |          |.. || .|.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDNKPPENPVTLLEMIREVEFSRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDE--ESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQ
 ..  |.  . .  ..   | |.        ||||||| | | || ..|. .|.|  .|   |.||.. .  ..|| | |.| . ..|.||.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 8-191 1.8e-33 110.4 In-house 5-197 (198) alignment 
Range on Protein: 8-191
Range on HMM: 5-197/198.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQ---GQGFYGDIDVTVEETVPKDDYILKIFTLKY----LNECRQVLHYWYTAW
 ..||| |. .||||||.|.| | .  ||||   .  | .   .|||    | | || . ||..  . | || .  . |          |.. || .|.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDNKPPENPVTLLEMIREVEFSRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDE--ESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQ
 ..  |.  . .  ..   | |.        ||||||| | | || ..|. .|.|  .|   |.||.. .  ..|| | |.| . ..|.||.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4-196 1.3e-32 108.0 In-house 79-276 (307) alignment 
Range on Protein: 4-196
Range on HMM: 79-276/307.0
REPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG---FYGDIDVTVE------ETVPKDDYILKIFTL--KYLNECRQV
 .|  |...|||.  |  .|| |.   .   ..|. |. |  . ||| |||  .|    .|.   |.       ...  |. .... ||  .. ...| .
ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrti

LHYWYTAWPDNKPPENPVTLLEMIREVEFSridptlpRGPVIVHCSAGLGRTGCYIAITLGMRQM-DEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQ
 |. .. |||.  |.  .| ....  |..        . ||.||||||.||.|  .||.| . .| . .   |.  .| ..|..|   |||. || ..|.
qhlqwenwpdrgvpqinltainlleavryd.......tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr

ALCLY
 |  |
vlley
0049772 (Phosphotyrosine protein) phosphatases II 7-201 3.2e-32 107.9 In-house 84-284 (314) alignment 
Range on Protein: 7-201
Range on HMM: 84-284/314.0
TAFVATQGPMAHTLADF----------WRMI--WFTNAPVIVM---------------------VTKIKERKrskcE----MYWPQGQgfygdidvtvEE
 .|.|||||. .|. ||          |||.  .  |  .|||                      ... ..          ..... .          ||
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk..........ee

TVPKDDYilkiftlkylneCRQVLHYWYTAWPDNKPPeNPVTLLEMIREVEFSridptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEeSMVDILGIV
. .....             |....|... .||. .|  .  ..|... .|        . |||.|||.|| ||||..... . |....  |. ..|  |
lydpelf............erlgikylripvpDgsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedv

CQIRQdRG---GMIQTNEQYEFIHQALCLYEKCLP
 ..|   .   |.|.. ||||||..||. | | |.
rlkRp.inpnpgfieqleqyefilealleylkflk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 7-197 3.6e-32 106.4 In-house 72-259 (267) alignment 
Range on Protein: 7-197
Range on HMM: 72-259/267.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSkcEMYWPQ-GQGFyGDIDVTVEETVPKD--DYILKIFTLKYLNEC-RQVLHYWYTAWPD
 ||..||.|.  | .||. .|   . ||||..||. . .     .. |. ||      |.||| .. |.  || .  . ||. ||. ..|  |.|  |  
nafivtqdplkntitdfltvihdqkvpvivlltkvftdnir..lfwPPkmgqak.kyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwni

NKppENPVTLLEMIREVEFSRIDPTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYE
|   .|   |  ..  .   ...      |..|.||.|.||.| .. |   .... .|...||   . .||. | |...| |.| .||. |. | 
nt..nnkpylkplfgilaknqleng..nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
PTPc_DSPc_SM00012 91-193 5.5e-32 105.5 In-house 1-103 (105) alignment 
Range on Protein: 91-193
Range on HMM: 1-103/105.0
QVLHYWYTAWPDNKPPENPVTLLEMIREVEFSRIDPTLpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEE-SMVDILGIVCQIRQDRGGMIQTNEQYEFI
.| ||.||.||| . ||..  .||..|.|. .. . .  ..||.|||||| ||||...|. . ..|...| . |||. ||...|. | ||.||.||| |.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HQAL
..||
yral
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 5-192 4.3e-31 102.9 In-house 74-290 (297) alignment 
Range on Protein: 5-192
Range on HMM: 74-290/297.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG-FYGDIDVTVEETVP-KDDY---ILKIFTLKYLNECRQVLHYWYTA
..  .. .|||.  |. |||....  .  |||||.|..|  |.||  |||. ..      || ||      |..   ||  ..| | .| |.| |  . .
adlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqfls

WPDNKPP---ENPV-----------------TLLEMIREVEFSRI---DPTLPRG-PVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQD
|||   |   |. |                 .|.||.  . | ..       ||  ...||||||.||.|  .     . ..  . . |.  |. ..|. 
wpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreq

RGGMIQTNEQYEFIHQA
|  ..|| ||.|....|
rarlvqtleqfellyda
0051082 (Phosphotyrosine protein) phosphatases II 9-193 6.7e-31 102.3 In-house 15-149 (151) alignment 
Range on Protein: 9-193
Range on HMM: 15-149/151.0
FVATQGPMAhtlaDFWRMIWFTNAPVIVMVTKIKERKrsKCEMYWPQGQgfygdidvtveetvpkddyilkiftlkylnecRQVLHYWYTAWPDNKPPEN
. ...||.|    ||.....  .  .||.... .||.  .|  |.|. .                                ..|||.... ||| . |..
lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................ievlhipildwpdpglpls

PVTLLEMIREVEFsridptLPRGPVIVHCSAGLGRTGCYIAITLGMrQMdeesmVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
. ..||......        . |||.||||||.||||. .|. | . ..     |..  .. ..|. |.|..|.|.|. |...||
fdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 8-193 7.5e-30 98.5 In-house 82-265 (281) alignment 
Range on Protein: 8-193
Range on HMM: 82-265/281.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGF---YGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPDNK
 .. ||||   | ||||||||  |.  |||. .. | .| ||  |.|.       .  . |. |..  .   .   . | |  | | . |. .  ||| .
gyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwq

PPENPVTLLEMIREVEFsRidPTlprgPVIVHCSAGLGRTGCYIAITLGMRQMDEE-SMVDILGIVCQIRQ-DRGGMIQTNEQYEFIHQAL
 ||    .|...|..   |   |    | ..|||||.||.|  .|. . .. .    .. ||  || ..|   |   .|| .|| .| . |
vpessevmlkilrkira.r..st....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
0044763 (Phosphotyrosine protein) phosphatases II 11-193 1.9e-29 98.0 In-house 33-167 (178) alignment 
Range on Protein: 11-193
Range on HMM: 33-167/178.0
ATQGPmahtlADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGfygdidvtveetvpkddyilkiftlkylnecrqvLHYWYTAWPDNKPPENPV
....|     ||......  .  .||..|. .|. . ||  |||.. |                                  ..| .. .||...|. . 
gslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................................iqylhipipDhgvpdlle

TLLEMIREVEFSR-IDPtlprGPVIVHCSAGLGRTGCYIAITLGMRQmdeeSMvDILGIVCQIRQDRGgMIQTNEQYEFIHQAL
 .||... .|  .  ..    |||.||||||.||.|. .|. | ...    .. ..  .. ..|. |  .... .|......  
hflefvefieealdekg....gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 8-196 6.6e-28 92.2 In-house 97-288 (305) alignment 
Range on Protein: 8-196
Range on HMM: 97-288/305.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDID--VTVE---ETVPKD-DYILKIFTL--KY-LNECRQVLHYWYT
 |...|||. .|. .|| |.   .   |||. |  |  . ||  |||  ||   ..   . ||    . | . |  ..| .|   |  ..   | |  .|
rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwt

AWPDNKPPENPVTLLEMIREVEFSRIdptlprgPVIVHCSAGLGRTGCYIAITLGMRQMDEESMV-DILGIVCQIRQDRGGMIQTNEQYEFIHQALCLY
 |||   |   .| ||..  .  |..       |..||||||.||||  .||   . .. |.  .  .  .|  .|..|   ||.. || |||. .  |
ewpdrgvppckltslellsairgskv.......pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 5-188 3.3e-26 86.7 In-house 88-272 (301) alignment 
Range on Protein: 5-188
Range on HMM: 88-272/301.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDID-----VTVEETVPKDDYILKIFTLKY---LNECRQVLHYW
.|  |.|||||.  |  ||| |. . .   |||...  |.. .||| | |.  .   ||.     .. .|.. ... . . . ..      . | |.|| 
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyq

YTAWPDNKPPENPVTLLEMIREVEFSRidptlprGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEF
|. |.|.  |.  . | ...  |  |.        |..||||||.||. ..|.     |... .  ...   . ..|..|   .|||.|  .
ysewtdrgvPkshaelfdlmelvkkse.......kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_ptpA1_pd Subfamily ptpA1 6-159 4.6e-26 86.5 In-house 88-258 (418) alignment 
Range on Protein: 6-159
Range on HMM: 88-258/418.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ------------GFYGDIDVTVEETV--PKDDYILKIFTLKYLNECRQ
|  |..||||.  |.||||||.|   . .|||...  |  | ||. |||.                .|   | . | .  |. . | .   | .  | |.
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd

VLHYWYTAWPDNKPPENPVT---LLEMIREVEFsRIDPTLPR-GPVIVHCSAGLGRTGCYIAITLGMRQMDE
. .| |  ||| . |.       ||  | . .  .| |.  |  |.|||||||.|||| . .  . |...| 
itqyqyegwpdhnipdhtqpfrqllhsitnrqn.qiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
0048076 (Phosphotyrosine protein) phosphatases II 57-194 1.8e-24 81.4 In-house 10-140 (145) alignment 
Range on Protein: 57-194
Range on HMM: 10-140/145.0
QGFYGDIDVTVEETVPKDDYILKIFTLKYLNE--CRQVLHYWYTAWPDNKPPENPVTLLEMIREVEFSRIDPtlprGPVIVHCSAGLGRTGCYIAITLGM
. ..|.. ....    ||  |  ...| .  |   |....|.|. |||. .|. . .|||... .|  . ..    |||.||||||.||||...|. | .
glylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylml

RqmdeESmVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
.    .. |..  .. ..|. | |.... .|..|..... 
l....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 8-196 2.9e-24 80.2 In-house 95-289 (310) alignment 
Range on Protein: 8-196
Range on HMM: 95-289/310.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG--QGFYGDIDVTVEETVPKDDYILKI-FT-----------LKYLNECRQVL
.|. .|||. ||. ||||||.   |  |... |. |  | ||  |||       || | ||      ..  | ..  |              |.| |  |
tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvsl

HYWyTAWPDNKPPENPVtllemiREVEfSRIDPTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
  |   |||   |.. .        |   |.   .  ||..|||||| .|... .|. | . ..|.   ||.  .. .....|   |||. || .|..  
ikw.pnwpdrgvpdekc......htvp.qrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr

CLY
 ..
iif
subfamily_CG42327_pd Subfamily CG42327 1-121 3e-24 80.3 In-house 66-192 (319) alignment 
Range on Protein: 1-121
Range on HMM: 66-192/319.0
GYDREPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG-----QGFYGDIDVTVEETVPKDDYILKIFTLKYLN--ECRQVL
|||  |. ..|.| ..  . .||||..|  .. ||| .|.. |    .|  |.|       .  |||| ||. .   || |..  . || ..  |.|.. 
GyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelt

HYWYtAWPDNKPPENPVTLLEMIREVEF
||||  |.. . | .. .|. |. ||. 
hywy.kwleaevPaeeaaliamllevrs
0048179 (Phosphotyrosine protein) phosphatases II 81-191 1.4e-22 75.4 In-house 48-139 (144) alignment 
Range on Protein: 81-191
Range on HMM: 48-139/144.0
FtlkylnecrqVLHYWYTAWPDNKPPENPVTLLEMIREVEFSRIdptlPRGPVIVHCSAGLGRTGCYIAITLGMrqmdEESmVDILGIVCQIRQDRGGMI
.          ...|... |||. .|. .  |||... .|  .     . |||.||||||.||||...|. | .    ..  ...  .. ..|. | |..
e..........giqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgav

QTNEQYEFIHQ
.. .|..|...
pnpgqlrfLle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 6-193 2e-22 74.6 In-house 81-267 (288) alignment 
Range on Protein: 6-193
Range on HMM: 81-267/288.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPKDDYILKIFTLKYL---NEC--RQ-VLHYWYTA
.  .. .| |.  |.  .|.|.  ..   |||.... |. . | . |.|  .|    |      .  | . | |. ..  |   .|   .. | .  .  
krrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlle

WPDNKPPENPVTLLEMIREVefsridpTLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQAL
|.|.  ||| .. | ..  .          . |..||.||| ||||  | | . ....  .  . |  .. . |..|   |||. || ..|. .
WdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 7-195 2e-22 74.5 In-house 75-268 (285) alignment 
Range on Protein: 7-195
Range on HMM: 75-268/285.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG---FYGDIDVTVEETVPK--DDYILKIFTLKYLN----ECRQVLHYWY
.....||||.  ||.|||.||.  .   ..|.  . |    || .|.|.  |    .|  ..|. |   .     ||. .|.   .    |   . |   
styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqv

TAWPDNKPPENPVTLLEMIREVEfsRIDPTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCL
  |||.  ||.   ..|. . |.  ...|     |. ||||||.|||  .. |     .. |.  ...| || ..|  |   .|.  |. |..  |  
pwwpdqlapedarpmielykwvk..kvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 69-193 4.3e-22 73.0 In-house 70-190 (440) alignment 
Range on Protein: 69-193
Range on HMM: 70-190/440.0
ETVPKDDYILKiftlKYLN--ECRQVLHYWYTAWPDNKPPENPVTLLEMIREVEFSRIDptLPRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDIL
. ||..|||       |.|  |.| . .| | .|||.  |.    .|.||..|. |.       ||..|||||| ||||  ||.   .|.      .||.
kgvpdsdyina....syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidif

GIVCQIRQDRGGMIQTNEQYEFIHQAL
 ..  .|..|  |.|| ||| |.|.|.
sfinsmrnnrpqmvqtpeqyafvheav
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 18-188 7.7e-21 69.3 In-house 39-212 (255) alignment 
Range on Protein: 18-188
Range on HMM: 39-212/255.0
HTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQG-FYGDIDVTVEETVPKDDYILKIFTL-KYLN---ECRQVLHYWYTAWPDNKPPENPVTL
 |.. |...|  |.. |.||..  .| .. ||. |.|  .       ||.|  | .  | .|.  ..  .|    . ..| || |. |.... ||..  .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LEMIREVEFSRidptlprgPVIVHCSAGLGRTGCYIAITLG----MRQMDEESMV--DILGIVCQIRQDRGGMIQTNEQYEF
|.... |  |.        .|.||||.| ||.  .. . |     .|..|. . |  | | .. ..|. | . |.|  |  |
lnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_egg_pd Subfamily egg 8-195 8.1e-21 69.0 In-house 84-268 (307) alignment 
Range on Protein: 8-195
Range on HMM: 84-268/307.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERkrSKCEMYWPQGQG----F-YGDIDVTVEETVPKDDYILKIFTLKYLNECR--QVLHYWYTAW
 |. .| |.  |  |||||..  . . |||.|  ||    .|| |||. .     .  | . ..  .   | | ....  || .   .  . | .|   .
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdv

PDNKPPENPVTLLEMIREVefSRidptlprgPVIVHCSAGLGRTGCYIAITLGMRQMDEESM--VDILGIVCQIRQDRGGMIQTNEQYEFIHQALCL
        |. .| ..|..  |.        ||.|..  |  .... .|| . . ..    .    .|  |  .|. |   ...  .| |... . .
nnssdvysplrvlrklrnl..sk........pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_CG42327_pd Subfamily CG42327 130-199 8.2e-21 69.0 In-house 247-317 (319) alignment 
Range on Protein: 130-199
Range on HMM: 247-317/319.0
RGPVIVHCSAGLGRTGCYIAITLGMRQMDEE-SMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKC
.||..|||| | ||||  ||  . .|...|    |||  .| ..|.||.  ..| ||||||.. |  | | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 15-189 8.4e-21 68.7 In-house 99-280 (302) alignment 
Range on Protein: 15-189
Range on HMM: 99-280/302.0
PMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ------GFYGDIDVTVEETVP--KDDYILKIFTLKYLNECRQ------VLHYWYTAW
|   ||  .| .|   |  ..| .....| .  ||  |. .        | |    | |.. .    |   .|..|... || ..      |    ..||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDNKPPENPVTLLEMIREVEFSRIDptlprgpVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFI
||   |... | |....  |  . .       |.||||||.||||  .||  |.    .. . |.| ||. .|| | | .|...|  ..
pdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 11-196 2.2e-19 64.7 In-house 64-258 (290) alignment 
Range on Protein: 11-196
Range on HMM: 64-258/290.0
ATQGPMA-------HTLADFWRMIWFTNAPVIVMVTKIKERKRS----KCEMYWPQGQG---FYGDIDVTVEETVPKDDYILKIFTLKYLNEC-RQVLHY
.|| | .        |. .|| |.   ..  .||. . .|...      |. | |.  |    .... |   . . .|| . .  ..|. .|   .| |.
ltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHs

WYTAWPDNKPPENPVTLLEMIREVEFSridptlpRGPVIVHCSAGLGRTGCYIAITLGMRQMD-EESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
..  | . . .|.. |||..|. |. |       . ||||||  |. |  .  || ||.  .   .. | .  .. ..|. |  .|...... |.  .. 
llkgWnklnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv

LY
|.
ll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 88-196 9.8e-19 62.2 In-house 184-286 (305) alignment 
Range on Protein: 88-196
Range on HMM: 184-286/305.0
ECRQVLHYWYTAWPDNKPPENPVTLLEMIREVEFSridptlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMV-DILGIVCQIRQDRGGMIQTNEQY
. |.| || .  |||   |   ...||.. .   |       .||..||||||.||||  . .   . |. .  .. |   |. .||..|   |||..||
karkvthyhwidwpdrgvpaadlailellekarps.......kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqy

EFIHQALCLY
 |.|| .  |
lfvhqvilny
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 5-201 3.1e-17 57.2 In-house 80-282 (312) alignment 
Range on Protein: 5-201
Range on HMM: 80-282/312.0
EPTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDID--VTVEET-------VPKDDY---ILKIFtLKYLNECRQV
 |  ||.||||.  | . ||..     .  |.... . |    ||  |  .  ||    |  |  |           ||     .||.  .|   .  ..
kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvv.vkatgqeskl

LHYWYTAWPDNKPPENPVTLLEMIREVEFSridptlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQA
 || ...|||   |.   | | ..  |          . ||| |||||.||||  . |   .  .      ..  .   .|.||   ...  || .  ..
nhyqwaswpdhgmpdscdtalrllsavkkd.......kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrc

L--CLYEKCLP
.   || | | 
vleflyskgly
subfamily_hpo-7_pd Subfamily hpo-7 18-188 5.2e-17 56.6 In-house 45-218 (263) alignment 
Range on Protein: 18-188
Range on HMM: 45-218/263.0
HTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG---QGFYGDIDVTVeeTVPKDDYILKIFTL-KYLN---ECRQVLHYWYTAWPDNKPPENPV
 |.. |...|  |.. |.||..  .|  . ||. |.|     .  . ...|..  |  ..| .||   | ..|.   . ..| || |. |.... ||.. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct..tkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

TLLEMIREVEFSRidptlprgPVIVHCSAGLGRTGCYIAITLG----MRQMDEESMV--DILGIVCQIRQDRGGMIQTNEQYEF
  |.... .  |.        ...||||.| ||.  .  . |     .|..|. | |  | | .. ..|. | . |.|  |  |
eilnilkvarnsk........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 8-68 3.4e-15 50.6 In-house 104-163 (350) alignment 
Range on Protein: 8-68
Range on HMM: 104-163/350.0
A-FVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQgfYGDIDVTVE
  ..|||.|.  |. ||...|   . .||...|.  |  . ||. ||..|.  | || | ..
fkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs..ydditvkla
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 134-194 4.5e-15 49.8 In-house 2-62 (69) alignment 
Range on Protein: 134-194
Range on HMM: 2-62/69.0
IVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
.||||.| |||| .||| . | ..  | .|||.  |  .|. |  |.  . .| ||| || 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 134-194 4.9e-15 49.6 In-house 1-61 (69) alignment 
Range on Protein: 134-194
Range on HMM: 1-61/69.0
IVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALC
.||||.| |||| .||| . | ..  | .|||.  |  .|. |  |.  ...| |||.|| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 17-198 5e-15 49.7 In-house 103-286 (302) alignment 
Range on Protein: 17-198
Range on HMM: 103-286/302.0
AHTLADFWRMIWFTNAPVIVMVTKIKERKRsKCEMYWPQGQGF---YGDIDVTVEEtVPKDDYILKIFTLKYL-NECRQ---VLHYWYTAWPDNKPPENP
.. ...||||..  .   .|.. . .| |.   . ..|. .|    ||.. | .   |.| .   . ...  | ..| .   .  |  | |...| |.. 
edsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvky

VTLLEMIREVeFSRIDPTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEK
 .| . . .| | .  ..    ....    | || |  .. .. . ...... . |  || .||..|  .... .|| ... || || |
aeliktaakv.fakkika..dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 91-197 2.8e-12 41.0 In-house 216-344 (350) alignment 
Range on Protein: 91-197
Range on HMM: 216-344/350.0
QVLHYWYTAWPDN---KPPENPVTLLE---MIREVEFSRID-PTLPRGPVIVHCSAGLGRTGCYIAITLGMR-------------QMDEESMV-D-ILGI
 |..  .  |.|      ||. .. ||    . .  |..    .    |..|||||| |||| ....   .              ..|  ... | |  |
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VCQIRQDRGGMIQTNEQYEFIHQALCLYE
| ..|. |  |.|. .|. ||..||  | 
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 10-192 6.5e-11 36.4 In-house 86-274 (303) alignment 
Range on Protein: 10-192
Range on HMM: 86-274/303.0
VATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQGFYGDIDVTVEETVPK-----DDYILKIFTLKYlNECRQVLH-YWYTAWPDN
. || |..|| ||||.||   .  .....    | ..   .. .|. | |    . ..     |     | . ||. ..    . .  || . | ||| |
iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn.gdyksflhvhhykawphn

KPPEN-PVTLLEMIREVEfSRIDPTLPRGPVIVHCSAGLGRTGCYIAI-TLGMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQA
. | .    ..  | ... | .    .  | .    .| ||.| .  . |  .   .|.. .|..  . ..|. |   .|   |. ...  
sipsdgspkfvkqiwqlq.svlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_eak_pd Subfamily eak 11-106 1e-10 35.6 In-house 97-195 (332) alignment 
Range on Protein: 11-106
Range on HMM: 97-195/332.0
ATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQ---GFYGDIDVTVEETVPKDDYILKIFTLKYLNECRQVLHYWYTAWPDNKPP
 |  .    .  ||.|.   ..| ||.. .  | |  | . |.|.       .| .||.  | | .. .  . . |.  ||  .|||| .  | . . |
ltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlp
0038934 (Phosphotyrosine protein) phosphatases II 92-192 2.4e-10 35.9 In-house 79-172 (194) alignment 
Range on Protein: 92-192
Range on HMM: 79-172/194.0
VLHYWYTAWPDNKPPENPVTLLEMIREVEFSRidPTLPRGPVIVHCSAGLGRTGCYIAITLGMR-QMdeesmvDILGIVCQIRQDRGGMIQTNEQYEFIH
 ..|    .||  .. .  .||. .. |..       | | | ||| |||||||. .|  | .| .|      .    .  .|. |.|.|.. ...| ..
gieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleall

QA
. 
kr
subfamily_PTPDC1_pd Subfamily PTPDC1 90-192 2.9e-10 34.9 In-house 80-171 (182) alignment 
Range on Protein: 90-192
Range on HMM: 80-171/182.0
RQVLHYWYTAWPDNKPPeNPVTLLEMIREVEFSridptLPRGPVIVHCSAGLGRTGCYIAITLGM-RQMDEESMVDilgivcQIRQDRGGMIQTNEQYEF
.| . ..  .|.| . .    ..|.... |.|.     | .| | ||| |||||||  ||  |   .... |  ..       .|. |   ||| || |.
eqgiyvynfgwkDygva.sleriLdivkvvafa.....lqegkvavhChaGlGrtGvliacylvyakrltaekaik......lvrskrpksiqtreqvel

IHQA
... 
vkef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 8-69 4.8e-09 30.0 In-house 108-167 (349) alignment 
Range on Protein: 8-69
Range on HMM: 108-167/349.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQGQgfYGDIDVTVEE
 ..||| |.  |. ||...|   . .... ... ||    ||..|| ...  | .| | . .
kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels..ysnitvklqn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 6-56 3.8e-08 27.4 In-house 87-137 (305) alignment 
Range on Protein: 6-56
Range on HMM: 87-137/305.0
PTAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERKRSKCEMYWPQG
|  |. || |. .| |||| | .  .   | |. ...|.   ||  |..  
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask
PTEN_1 93-180 3.9e-08 28.3 In-house 95-178 (196) alignment 
Range on Protein: 93-180
Range on HMM: 95-178/196.0
LHYWYTAWPDNKPPeNPVTLLEMIREVEFSRID-PTlpRGPVIVHCSAGLGRTGCYIAITLGMRQMdeESMVDILGIVCQIRQDRGGMI
. |.   ..|  .| .   |........ ...  |   .. |.||| |||||.|. .|  |  ..    .. . | .|.. |  ..  .
veylhfpieDhgap.slselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvvaayLmykgk..ltadeAlelvrekRppgapns
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 7-55 1.2e-07 25.4 In-house 236-281 (440) alignment 
Range on Protein: 7-55
Range on HMM: 236-281/440.0
TAFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERkrsKCEMYWPQ
 ||.||| |.  |. ||||..   .   |.|. .....    | .||| 
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
subfamily_CDC14_pd Subfamily CDC14 130-191 1.3e-07 25.8 In-house 263-320 (328) alignment 
Range on Protein: 130-191
Range on HMM: 263-320/328.0
RGPVIVHCSAGLGRTGCYIAITLgMRQMDeesmVDILGIVCQIRQDRGGMIQTN-EQYEFIHQ
.| ..||| |||||||. ||  | |..      .    ..  .|  | |.. .. ...   .|
eGaiavhCkaGLGrtGtLiacyl.mkhyr....ftaaeaiawlricrPGsvigpqqkfleekq
subfamily_DSP23_pd Subfamily DSP23 132-198 2.4e-07 25.5 In-house 86-147 (148) alignment 
Range on Protein: 132-198
Range on HMM: 86-147/148.0
PVIVHCSAGLGRTGCYIAITLG-MRQMdeeSMVDilgIVCQIRQDRGGMIQTNEQYEFIHQALCLYEK
 | |||  | ||||  .|  |  .|..   .  .    . ..|. | | ..| || . ...  ....|
avsvhcllgrgrtgtmlacylvkerkl...aaae...aiaevrrlrpgsvetveqeklvrdyetfink
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 91-196 4.6e-07 23.5 In-house 219-343 (349) alignment 
Range on Protein: 91-196
Range on HMM: 219-343/349.0
QVLHYWYTAWPDNKPPENPVTLLEMIReVEFSRIDPTLP--------RGPVIVHCSAGLGRTGCYIAITLGMR--QMDEESMV---------D-ILGIVC
..|   .  |.|     ||...|. .  |    ||              ...|||||| |||| .. . | .   .. .. ..         | |  || 
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

QIRQDRGGMIQTNEQYEFIHQALCLY
..|. |  |.|   |. .|..||  |
elrkqrismvqnlaqfiaiyealLky
PTPc_motif_SM00404 130-198 7.1e-07 24.2 In-house 80-139 (140) alignment 
Range on Protein: 130-198
Range on HMM: 80-139/140.0
RGPVIVHCSAGLGRTGCYI-AITLGMRQMDEESMVDILgivcqiRQDRgGMIQTNEQyeFIHQaLCLYEK
.| |.||| ||. |... | |  .  ||.. .. ....      ...|  .|. |..  |..| |. |||
ggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefv......kerR.piispnln..fvrq.Lieyek
subfamily_CDKN3_pd Subfamily CDKN3 132-191 1.6e-06 21.8 In-house 134-190 (202) alignment 
Range on Protein: 132-191
Range on HMM: 134-190/202.0
PVIVHCSAGLGRTGCYIAITLgMRQMDEESMVDIlgiVCQIRQDRG-GMIQTNEQYEFIHQ
  .|||  ||||.   ||  | .   |  .. |    . ..|. .| . |||  ||.....
ktlvhcygglgrsslviacll.lylddtiepkda...idklrdlkgsraiqtvkqynylse
Y_phosphatase3 Tyrosine phosphatase family 130-162 3.7e-06 22.0 Pfam-A 124-156 (164) alignment 
Range on Protein: 130-162
Range on HMM: 124-156/164.0
RGPVIVHCSAGLGRTGCYIAITLGMRQMDEESM
.|||..||.||  |||  .|..| .  .||| .
egpvlfHCtaGKDRTGvvaalllsllgvdeeti
DSPc Dual specificity phosphatase, catalytic domain 130-195 4e-06 21.7 Pfam-A 73-129 (133) alignment 
Range on Protein: 130-195
Range on HMM: 73-129/133.0
RGPVIVHCSAGLGRTGCYIAITL-GMRQMDEESMVDILgivcqiRQDRgGMIQTNEqyEFIHQaLCL
.. |.||| ||. |... |.  |   .... .. ....      ...| ..|  |.  .|..| |. 
gkkvlVHCqaGisRSatliiaYlmktknlslneAyefv......kerr.skispna..gflrq.Lle
DSPc Dual specificity phosphatase, catalytic domain 130-195 4e-06 21.7 In-house 73-129 (133) alignment 
Range on Protein: 130-195
Range on HMM: 73-129/133.0
RGPVIVHCSAGLGRTGCYIAITL-GMRQMDEESMVDILgivcqiRQDRgGMIQTNEqyEFIHQaLCL
.. |.||| ||. |... |.  |   .... .. ....      ...| ..|  |.  .|..| |. 
gkkvlVHCqaGisRSatliiaYlmktknlslneAyefv......kerr.skispna..gflrq.Lle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 8-71 4.3e-06 20.5 In-house 138-197 (244) alignment 
Range on Protein: 8-71
Range on HMM: 138-197/244.0
AFVATQGPMAHTLADFWRMIWFTNAPVIVMVTKIKERkrskcEMYWPQGQGF-YGDIDVTVEETV
 .. || |.| |  |||.|.      |.|..  ..|      . |||. . . . . |.||  | 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltd
subfamily_PRL_pd Subfamily PRL 129-189 4.5e-06 20.8 In-house 89-142 (151) alignment 
Range on Protein: 129-189
Range on HMM: 89-142/151.0
PRGPVIVHCSAGLGRTGCYIAITLGMRQMDEESMVDIlgivcqIRQDRGGMIQTnEQYEFI
|   | ||| |||||.   .|..|    |. |  |..      ||. | | | . .| .|.
pkstvavhcvaGlGraPvlvalalieaGmkyedavef......irekrrgains.kqlkfl
subfamily_PTEN_pd Subfamily PTEN 130-189 5.5e-06 21.5 In-house 114-172 (184) alignment 
Range on Protein: 130-189
Range on HMM: 114-172/184.0
RGPVIVHCSAGLGRTGCYIAITLgMRQMDEESMVDILGIVCQIRQDRGGMIQTNEQYEFI
.  |.||| || ||||  |.  | . ..  |.. ..| .  ..|   .  ..   |  ..
knvvvvHCkaGkGRtGvlivayl.lkslllekaeealelfaeaRtknkkgvtiPsqrRYv