Gene PTPN6-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP065_AA protein Get Run
SpurP065_AA_220-449 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 290-454 2.2e-81 268.2 In-house 137-302 (306) alignment 
Range on Protein: 290-454
Range on HMM: 137-302/306.0
INKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFP--DAGSIIVHCSA
 .||.|||||...|...|.|.||..||.|.|||.|||.|.|.|.. .|.| .|..|||||||||||.||. ||.||.|||.|||..   .||.|.|||||
kekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsa

GIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETlSQR
|||||||||||||.|.||...|||..|||......||.|||||||||.||||||.|...|||| ...
GiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet.kkk
0046845 (Phosphotyrosine protein) phosphatases II 237-451 3.8e-64 212.1 In-house 1-277 (284) alignment 
Range on Protein: 237-451
Range on HMM: 1-277/284.0
GFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYNIK-------------VDQLDSNCVAI---------------------------------
|.|||||.|. |  |.||..... . ||.||||||.||||.                |  . . |                                   
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

----------------NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQET
                .||..|||. ....  | .||| .||. . || .|...........||| . |||..||||||||..|. .|.||..|.. .| 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
.|. | |.||||||.|||||||..|..|......||....|...... .|.|| | |||..||.|||.|...|. ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0050432 (Phosphotyrosine protein) phosphatases II 222-452 2.2e-61 203.2 In-house 30-303 (308) alignment 
Range on Protein: 222-452
Range on HMM: 30-303/308.0
VLEKETKSreNSKKAGFEEEFEALQLLDNkhLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSN-----------------CVAI--------------
 | |  ..     . ..|||||.|. . .  ||..... . |||.|||||.||||      ||..                 .  |              
dllkllek..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFw

----------------------NKCCRYWPDA--NTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQ
                      .||..|||.   .. .  | .|||..||....|| .|.. ..... . ||| . |||...|||||||..|. .|.||.
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldfle

DVNKKQetfPDaGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
 |.|..   |. | |.||||||.|||||||..|..|......   ...|...... .|.|| | |||. ||.|.|||...|.... 
lvrksl...pg.gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 221-448 1.3e-60 201.1 In-house 12-304 (307) alignment 
Range on Protein: 221-448
Range on HMM: 12-304/307.0
EVLEKETKSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDS-------------NCV-------------------
..|... . .  . ..|...||| |. .  ..| ...|. . |||.|||||.||||.    .| |             . |                   
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

---------------------------------AINKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVP
                                 . .||..|||| ....  | .||| .||. ...| .| . ....|. .|||   |||...|||||||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

SDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
.... .|.|.. |.| .|. |. | ..||||||.|||||||.....| .....|  . .|......|.|.||.| ||.. ||.|.|.|.....
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0051299 (Phosphotyrosine protein) phosphatases II 223-448 5.3e-60 198.7 In-house 17-286 (288) alignment 
Range on Protein: 223-448
Range on HMM: 17-286/288.0
LEketksreNSKKAGFEEEFEALQLLDNKhlLPRKIGDKAENKSKNRYKNILPYNIKVDQLDS------------NCVAI--------------------
|         . ..|..||||.|. |  .  |..... . ||..||||..||||.    .| .            . . .                    
ll.......angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

------------------------NKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHKD---FPEESRPMFHFHFKSWPDHGVPSDPSRVLN
                        .||..|||. ....  | |||| .||....|| .|.. ....|   ...|||   |||...|||||||..|. .|.
FWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

FLQDVNKKQEtfPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
||..|.|...  .. | ..||||||.|||||||..|..|......    ..|...... .|.|| |.|||. ||.|||.|. .|.
flrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 228-451 7.4e-59 194.8 In-house 5-280 (297) alignment 
Range on Protein: 228-451
Range on HMM: 5-280/297.0
KSRENSKKAGFEEEFEALqlLDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSNC----------------------------------------
.... . .|....||| |  |....| ..... . ||..|||||.||||.    .||..                                         
llekllflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

------------VAINKCCRYWPDA-NTKKDTGVITVTHISEQS--MADYDLREFSMSHKDFPeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQ
               .||..|||.  .  .  | .||| .|...   .|| ||.. ..... . ||| . |||...|||||||..|. .|.|.. |.|..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvl

ETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
. .|. | ..||||||.||.||||..|..|......   ...||..... .|.|| | |||. ||.|.|.|..... . 
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPRD_pd Subfamily PTPRD 291-461 1.4e-58 193.9 In-house 131-294 (564) alignment 
Range on Protein: 291-461
Range on HMM: 131-294/564.0
NKCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMsHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPDAGSIIVHCSAGIG
.|| .|||. . ..  | .|||  .|. .||| .|.|.. .|   .|||   .||| ||||||||  .  .|.....|.. .|  |||| |.||||||.|
vkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVG

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNT
|||||||||..|. ||.   .  .|||......|.||  .|||| || |...|......  .. | .|. .
RTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlk
0047943 (Phosphotyrosine protein) phosphatases II 232-448 6e-58 191.8 In-house 8-272 (273) alignment 
Range on Protein: 232-448
Range on HMM: 8-272/273.0
NSKKAGFEEEFEALqlLDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQL-----------------------------------------DSNCVA-
 . .....||||.|  |..|.||..... . |||.|||||.||||.     |                                         . |.   
llgltllleefell..lslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

----------INKCCRYWPDANT--KKDTGVITVTHISEQSMADYDLREFSMSHKDFPEeSRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPD
           .||..|||. .   ..  | .|||..||.. .|| .|.. .......| || . |||...|||||||.... .|.|...|.|..|..|.
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealps

AGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
 | ..||||||.|||||||..|..|.... .|   ..|......|.|.|| | |||. ||.|.|.|. .|.
ngpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 232-455 1.6e-57 190.6 In-house 14-283 (317) alignment 
Range on Protein: 232-455
Range on HMM: 14-283/317.0
NSKKAGFEEEFEALQLLDNKhllPRKIGDKAENKSKNRYKNILPYNIKVD-----------------------------------------------QLD
.| . ...|||| |. |.     ..... . |||.||||..||||                                                    ...
ksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

SNCV---------AINKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHKdFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtf
....           .||..|||. ....  | .|||..||. .|.. ||.. ....   .||| . |||...|||||||..|. .|.||. |....|  
vtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..

PDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRV
.. | ..||||||.|||||||.....|......|   ..|...... .|.||.| |||..||.|.|.|...|. .  ...
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
0043336 (Phosphotyrosine protein) phosphatases II 233-448 1.5e-54 180.7 In-house 17-277 (278) alignment 
Range on Protein: 233-448
Range on HMM: 17-277/278.0
SKKAGFEEEFEALqlLDNKHlLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSNC---------------------------------------------
. |.....||| |  |..|.  ...|. . |||.|||||.||||. .  .|..                                               
nlktllllefeel..lsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

-----------VAINKCCRYWPdaNTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEEsRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfP
              .||..|||  .. .  | .||| ..|....|| .| . ....  .|. |   |.|...|||||||...| .|.||..|....|  .
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale..d

DAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
. | ..||||||.|||||||.....|.... .|   ..|...... .|.|| | |||. ||.|.|.|...|.
sngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 219-450 2.1e-54 180.4 In-house 15-291 (297) alignment 
Range on Protein: 219-450
Range on HMM: 15-291/297.0
RVEVLEKETKSRENSKKAGFEEEFEALQLLDNkhllPRKIGDKAENKSKNRYKNILPYNIKVDQLDS---------------------------------
...||.   . .  ..| ....||| |. |      ...|. . |||.|||||.||||.    .| .                                 
plsvldlllllekansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

--------------NCV-----------AInKCCRYWPDANTkkDTGVITVTHISEQSMADYDLREFSMSHkdfPEESRPMFHFHFKSWPDHGVPSDPSR
              ..               ||..|||.  .    | .||| ....  ..| .|......    .||| . ||.. .|||||||.... 
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslel

VLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
.|.||. |.. ... |. | ..||||||.|||||||.....|.... .   ...|...... .|.||.| |||. ||.|.|.|..... .
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040439 (Phosphotyrosine protein) phosphatases II 257-448 1.3e-50 167.7 In-house 4-246 (249) alignment 
Range on Protein: 257-448
Range on HMM: 4-246/249.0
KIGDKAENKSKNRYKNILPYNIKVDQLDS--------------------------------------------------------NCVAINKCCRYWPDa
... . |||.||||..||||.    .| .                                                             .||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

NTKKDTGVITVTHISEQSMADYDLREFSMSHKdFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDI
.. .  | .||| .|.....|| .|.. ....    |||   |... .|||||||.... .|.|.. |.| .|. |. | ..||||||.|||||||....
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
.|.... .   ...|......|.|.||.| ||.. ||.|.|.|.....
mleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 258-448 1.1e-49 164.6 In-house 4-242 (243) alignment 
Range on Protein: 258-448
Range on HMM: 4-242/243.0
IGDKAENKSKNRYKNILPYNIKV------------------------------------------DQLDSNCVA---------INKCCRYWPdaNTKkDT
|. . ||.|||||..||||.                                              .|.....           .||..|||  ...   
iallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.ty

GVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQET------FPDAGSIIVHCSAGIGRTGTFIVIDI
| .||| .||....|| .|.......| ....|  .|.|. .|||||||..|. .|.||..|.. .|        .. | ..||||||.|||||.|....
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

ILNLIkqhgldcEIDIYNTIRLVRQQRSG-LVQTEAQYKFVYRAVQHYI
.| |.       ..|......|.|.||.|  |||. ||.|.|.|.....
mllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 259-450 1.4e-48 161.0 In-house 28-274 (278) alignment 
Range on Protein: 259-450
Range on HMM: 28-274/278.0
GDKAENKSKNRYKNILPYNIK-----------------------------------VDQLDSNCV---------AINKCCRYWPDaNTKKDTGVITVTHI
. . .|..|||||.||||.                                     . .|.....         . .||..|||. .  .  | .||| .
alylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtll

SEQSMADYDLREFSMSHK---DFPEESRPMFHFHFKSWPDHGVPSDP--SRVLNFLQDVNKKQE-----------TFPDAGSIIVHCSAGIGRTGTFIVI
||. . || || . . .    .   ||| ..|.|...||||||||.|  . .|..|. ... ..           .... | ..||||||.|||||....
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

DIILNLIkqhglDCEIDIYNTIRLVRQQRSG-LVQTEAQYKFVYRAVQHYIET
...| |.     .. .|...... .|.|| |  ||.. ||.|.|........ 
ylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 290-460 2.1e-48 160.0 In-house 128-292 (318) alignment 
Range on Protein: 290-460
Range on HMM: 128-292/318.0
INKCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGI
 .|. ||||. ...   | ..|.  .| ...|| ||||......  |||| .  .|. ||||.|||.... .|.....|.| |.. ..|| |.||||||.
kakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk.sgagpivvhCsaGv

GRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQN
||||.||..||.|. ||. .|   .|...|.. .|.||  .|||| ||.|.| ... ....  . | |.. 
GrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdl
0042113 (Phosphotyrosine protein) phosphatases II 259-449 3.2e-48 159.7 In-house 4-244 (245) alignment 
Range on Protein: 259-449
Range on HMM: 4-244/245.0
GDKAENKSKNRYKNILPYNIKVDQLDSNCV--------------------------------------------------------AINKCCRYWPDaNT
. . |||.||||..||||.    .| .                                                             .||..|||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

KKDTGVITVTHISEQSMADYDLREFSMSHkDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGRTGTFIVIDIIL
.. .| .||| .||....|| .|...... .   |||  .|.|. .|||||||.... .|.||. |.| ..  .. | ..||||||.|||||||.....|
sltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylml

NLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
.... .   .......... .|.||.| |||. ||.|.|.|......
eqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 292-455 4.4e-48 159.0 In-house 132-290 (319) alignment 
Range on Protein: 292-455
Range on HMM: 132-290/319.0
KCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGR
|. .|||..| . . | ..||  .|. ..||  |.... .|    |.| ..||....||||.|| .   .|..|....| .|  ...| |.||||||.||
klkkywpeenfe.eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPivvhCsaGvGR

TGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRV
||||||.|..|. .|. |.   .|...|.. .| ||  .||...||||.| |. ...|. .  .
tGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdtei
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 291-458 1.9e-47 156.9 In-house 129-293 (305) alignment 
Range on Protein: 291-458
Range on HMM: 129-293/305.0
NKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAG-SIIVHCSAG
.|| .|||.. |. |. | ..|.  ||....||  |....| .|  .||| . .... .|||||||  .. .|.....|.|.|.   | | ...||||||
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk..dkgvpllVhCsag

IGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAE
.||||.||..|| |. .|. .   ..|... .. .|..| ..||| .|| |.. |.. .|..    .  .
vgRtGvfiavdialerlkkEe...vvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigs
subfamily_PTPRB_pd Subfamily PTPRB 291-451 1.6e-46 153.7 In-house 134-288 (293) alignment 
Range on Protein: 291-451
Range on HMM: 134-288/293.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHkdfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIG
 || .|||. ..    | |.|| ..|... |. .||.....    .|.| . ..||.||||||||.... .|.|.. |....|.  ... |.||||||.|
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
|||||| .| .|. |... .   .||. ..  .|..|  |||||.|| |....|...... 
RtGtfialdrllqaieeedy...vdifgivaelReeRnllvqtekqYifihqcvldllrkk
DSPc_SM00195 290-448 1.7e-46 154.1 In-house 108-262 (263) alignment 
Range on Protein: 290-448
Range on HMM: 108-262/263.0
INKCCRYWPDA-NTKKDTGVITVTHISEQSMA-DYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpdAGSIIVHCSA
 .|| ||||.  ..|.. | |.|. ......  .. ||........  ||.| . ....|.|||||||.... ||..|. |.|...|    | |.|||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|.||||||..|||||. ....     .|| .... .|.|| |.|||..||.|.|.|. .||
GvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 290-448 1.7e-46 154.1 In-house 108-262 (263) alignment 
Range on Protein: 290-448
Range on HMM: 108-262/263.0
INKCCRYWPDA-NTKKDTGVITVTHISEQSMA-DYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpdAGSIIVHCSA
 .|| ||||.  ..|.. | |.|. ......  .. ||........  ||.| . ....|.|||||||.... ||..|. |.|...|    | |.|||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|.||||||..|||||. ....     .|| .... .|.|| |.|||..||.|.|.|. .||
GvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN12_pd Subfamily PTPN12 291-451 9.5e-46 151.0 In-house 123-280 (290) alignment 
Range on Protein: 291-451
Range on HMM: 123-280/290.0
NKCCRYWPDANTKKD-TGVITVTHISEQSMA-DYDLREFSMSHKdfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPDAGSIIVHCSAG
.|| ||||. . ..  .| ..|| ..|. .  |. .| . . ..   .||| .  ||...|||||||| ....|.....|.. ||   ..  ..||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaG

IGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
.||||| |.||.. .|.|.. .. |.|... .. .|.||. ||||. ||..||.|| ..... 
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 291-454 9.2e-45 148.1 In-house 139-296 (298) alignment 
Range on Protein: 291-454
Range on HMM: 139-296/298.0
NKCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKDFPeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDaGSIIVHCSAGIG
 |. .|||| ...   | |||.  |....||.  |.. .|.|.   ..| . ..|| ||||.|||.  . ||..|..|...|.   .  ..||.||||.|
tkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagn.kpvivqCsaGvg

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQR
|.||||.|| .|. .|.   .  .|...... .|..| |.||||.||.|.| ||...... .. 
RsGtfiaidsvlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
Y_phosphatase Protein-tyrosine phosphatase 291-445 1e-44 148.1 Pfam-A 82-234 (235) alignment 
Range on Protein: 291-445
Range on HMM: 82-234/235.0
NKCCRYWP-DANTKKDTGVITVTHI-SEQ-SMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetFPDAGSIIVHCSA
.|| .||| . .... .| |.|.   .|.  ...| ||......|. ..|.| . ..|...|||||||..|. .|.....|.|..   .. |...|||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|.||||||...||.|. .....    .|...... .|.|| |.||...||.|.|.|..
GvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 291-445 1e-44 148.1 In-house 82-234 (235) alignment 
Range on Protein: 291-445
Range on HMM: 82-234/235.0
NKCCRYWP-DANTKKDTGVITVTHI-SEQ-SMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetFPDAGSIIVHCSA
.|| .||| . .... .| |.|.   .|.  ...| ||......|. ..|.| . ..|...|||||||..|. .|.....|.|..   .. |...|||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|.||||||...||.|. .....    .|...... .|.|| |.||...||.|.|.|..
GvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRA_pd Subfamily PTPRA 291-448 1.6e-43 143.9 In-house 141-295 (330) alignment 
Range on Protein: 291-448
Range on HMM: 141-295/330.0
NKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMS-HKDFP--EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSA
.|| .||||  .    | |.|.   |. . || .|.| .    |    ..|| .  |||.|||| |||..|  .|..|. |.|...    ||.|.|||||
ekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq..sagpivvhcsa

GIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|.||||||||.| .|. .|  .    .|...... .|.||. .|||. ||.|.|.....| 
GvGrtGtfivldavlervkaer...kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPRK_pd Subfamily PTPRK 288-444 6.9e-43 141.6 In-house 123-273 (314) alignment 
Range on Protein: 288-444
Range on HMM: 123-273/314.0
VAINKCCRYWPDANTKkdTGVITVTHISEQSMADYDLREFSMSH-KDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCS
|.  ||..|||.  ..   | | |. .. .  |..  | |.... .   || | . .|.| .||||.||     .|.... |.|.||   .|| |.||||
vgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCs

AGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|| |||||||.|||.|..|...|.   .|..|... .|.... .|.|| ||||.| ..
aGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN13_pd Subfamily PTPN13 292-450 2.1e-42 140.3 In-house 118-271 (273) alignment 
Range on Protein: 292-450
Range on HMM: 118-271/273.0
KCCRYWPDANTKKDT--GVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfpDAGSIIVHCSAGI
|| ||||. . || .  . ..|. .  | . .. .|.. .....  .||| . |..| .|||||||| .  .|.|.. |.. |.   ||| |.|||||||
kchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse.sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGi

GRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
||.||.|.||..|.||..     |.|. ...| .|.|| |.|||. || |||.|. . ...
GrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 292-450 2.3e-42 140.0 In-house 125-278 (281) alignment 
Range on Protein: 292-450
Range on HMM: 125-278/281.0
KCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDaGSIIVHCSAGIGR
|| ||||| |..   | .||....|.. | |  |.|......   |.| . ......|||||||.... .|.| ..|.| .|.  .  ....|||||.||
kChrYWPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGr

TGTFIVIDIILNLIKQHGldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
|||.| .| ... ....    |.|. .... .|..|  .||| .||.|||.|| .... 
tGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 291-449 3.3e-42 139.5 In-house 130-280 (288) alignment 
Range on Protein: 291-449
Range on HMM: 130-280/288.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMShKDfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSAGIG
.|| .|||||...|  | .||| .... . |. ||.. .  |.  .. . . ......||||||| .   .|..|. |.  ..   |.| ||||||||.|
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kk..kteleitqyqylaWpdhgvPeskapllellrqvkvanqa..dtgpiivhCsaGvG

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
||||||..| ... ...   .  ||. .|.  .|.||  ||||. || |.|... . ||
rtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_PTPRG_pd Subfamily PTPRG 291-472 5e-42 138.9 In-house 131-312 (563) alignment 
Range on Protein: 291-472
Range on HMM: 131-312/563.0
NKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSH---KDFPE--ESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVnkKQETFPDAGSIIVHC
.|| .|||  .. .. |...|| |.|. .| |  |.... .   |.. .  . . . ..|. .|||||||. .  ||.| .    .. .  .|| |.|||
rkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHc

SAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQ-NTLKTGREYINTK
|||.|||||.||.| .|. |.|.     ........ .| ||  ||||| || |.. |..  | .  . . ||| . ||    |.. .
saGvgrtGtyivldtllkqiqqen...avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyleqq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 292-452 5.6e-42 138.7 In-house 92-246 (250) alignment 
Range on Protein: 292-452
Range on HMM: 92-246/250.0
KCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGR
.. .|||  .. .  | .||.  |.. .|||  |.. .|..   ...| . ..|| .||| |||     ||..|..|...|.   ... .||.||||.||
tyhqywPveka.ekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgr

TGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
.|.||.|| .|. .|.   .  .|... |. .|..| . |....|| |||...........
sGafiaidavlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_PTPN9_pd Subfamily PTPN9 291-449 1e-40 134.6 In-house 125-291 (297) alignment 
Range on Protein: 291-449
Range on HMM: 125-291/297.0
NKCCRYWP-DANTKKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETF-----------PDA
 || .||| . .. .. | ..|.... ... ||  | . ... .  |||| . || | ||||.||||. . .|..|. | .|| ..           |. 
lkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsg

GSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
  |.|||||||||||||| .|| |. ... |    .|. .|..|.|.||.  .||. ||.| | ||  |  
PPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 290-445 1.2e-40 134.7 In-house 137-288 (319) alignment 
Range on Protein: 290-445
Range on HMM: 137-288/319.0
INKCCRYWPDA-NTKKDTGVITVTHISEQsmADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAG
 .||..|||   . |.. . . |. . |   |.| .|.. .|..   .. | .  |||. |||.|||  || .. ... |.. ..   .  .|.||||||
kdkcsqywplkivikeerfkvkvdsveet..aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
.||||..||.|..|. .|.   .  .|.||..| .||||. |||  .||||.| |. 
vGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 290-445 5.3e-40 132.7 In-house 101-252 (284) alignment 
Range on Protein: 290-445
Range on HMM: 101-252/284.0
INKCCRYWPDA-NTKKDTGVITVTHISEQsmADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAG
 .||..|||   . |.. . . |. ..|   ..| .|.. .|..   .. | .  |||. |||.|||  || .. ... |.. ..   .  .|.||||||
kdkcsqywplkivikeerfkvkvdsvees..eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

IGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
.||||..||.|..|. .|.   .  .|.||..| .||||. |||  .||||.| |. 
vgrtgvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 291-451 5.9e-40 132.1 In-house 113-271 (274) alignment 
Range on Protein: 291-451
Range on HMM: 113-271/274.0
NKCCRYWPDANTK---KDTGVITVTHISEQSMADYDLREFSMSHKDFpeeSRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDA-GSIIVHCS
.|| .|.|||.     .  | . ..  .  .  || .|......      .| . |. . .|||| .| |.. .|.....|....|.     ....||||
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCs

AGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
||||||| || |.| .. ...   .  .|. ...  .|..| |.|||. ||....||. .| . |
aGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 291-454 1.2e-39 130.9 In-house 104-270 (270) alignment 
Range on Protein: 291-454
Range on HMM: 104-270/270.0
NKCCRYWPDANTK---KDTGVITVTHISEQSMADYDLREFSMSHKdfPEESRPMfHFHFKSWPDHGVPSDPS------RVLNFLQDVNKKQETFPDAGSI
.|| ||||  . .     .| |.|. .||. .  | |..  . .|   || | . ||....|||||||...        .|. |..| . .. . .|. .
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleek..geerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

IVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQR
.||||||.|||||.|..||...|.....   ..|. . |. .|..|  |||.  ||.|.|.||..|.|....|
lvHcsaGvgRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrakr
subfamily_PTPN1_pd Subfamily PTPN1 291-453 1.1e-38 127.6 In-house 111-276 (290) alignment 
Range on Protein: 291-453
Range on HMM: 111-276/290.0
NKCCRYWPDANT----KKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCS
.|| .|||  .     . .   ..|. |||..   | .| . .  .   .|.| ..|||. .||| |||. |.  |.||..| .     .| |  ..|||
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQ
|||||.|||...| .| ||....    .|| ...  .|..| ||.||  | .| | |. . . .. .
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
subfamily_Ptp69D_pd Subfamily Ptp69D 291-449 2.9e-38 126.7 In-house 131-287 (307) alignment 
Range on Protein: 291-449
Range on HMM: 131-287/307.0
NKCCRYWPDAnTKKDTGVITVTHISEQSMADYDLREFSMSHKD--F--PEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpdAGSIIVHCS
.|| .|||.  ...  | | |. .||... ||  ||...|.|.      |.|| .  .|...|.|  ||  .  .|.... |.. ...    . |.||||
kkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCs

AGIGRTGTFIVIDIilnLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
|| ||.|.|. .|.   |..|  .. ..||..|.. .|.||. |||  .||.|.|||.  |..
aGvgrsgifvalds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN3_pd Subfamily PTPN3 291-446 6.8e-38 125.2 In-house 124-273 (280) alignment 
Range on Protein: 291-446
Range on HMM: 124-273/280.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDagSIIVHCSAGIG
 ||..|||. . . . | ..|.  .|..   | |||. ...|.  .|.|..... . .|||||||.|.. .|.|.. |.|....  .   ..||||||||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsgkee..PvvvhCsaGig

RTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQH
||| .|.... | || ..    .. . . .| .|.||. ||||..|||||  |. .
rtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfvCeailk
0051429 (Phosphotyrosine protein) phosphatases II 288-452 3.2e-37 124.0 In-house 58-229 (272) alignment 
Range on Protein: 288-452
Range on HMM: 58-229/272.0
VAINKCCRYWP-----------DANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPsrVLNFLQDVNKkqetfp
.. .|| ||||           |. .    | ..||..||. . || |||. ....  ..|.| ..|.|. .|||||||...  .|..|. ...      
rgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......

dAGSIIVHCSAGIGRTGTFIVIDIILnliKQHGLDCEID--------IYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
  | ..||||||..||||.......|    . .|.. .|        ...... .|.|| | ||||.||.|.|.|.......| 
.ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 291-449 8.6e-36 118.1 In-house 126-277 (515) alignment 
Range on Protein: 291-449
Range on HMM: 126-277/515.0
NKCCRYWPD--ANTkKDTGVITVTHISEQSMADYDLREFSMSHKDfpeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPdaGSIIVHCSAG
 || .||||  ...    | | |  .| .. ..   |.. . . |   .|| .  |||. |||.||| . | .| ....|  ... .    ..|.|||||
ikcgkyWPdkpgds.vkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaG

IGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
.|||| .| || ..  .|.      .|..|... .||.|  ||||. || |.| ||. .. 
vGrtGvvisidsvvahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 291-444 2.3e-35 117.0 In-house 132-275 (315) alignment 
Range on Protein: 291-444
Range on HMM: 132-275/315.0
NKCCRYWPDAntKKDTGVITVTHISEQSMADYDLREFSMSHKDfpeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSAGIG
.|. .||||   |   | ||||..||.   .|  | .|.  .|   . | .. .|. |||| |||     ..|. . |.. ...  ..|.|.||||||.|
rkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtn..svgaivvhcsaGvG

RTGTFIVIDIILNlikQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|||||| .| .|.   |   .  ||.|| |. |||.| ..||. .||.|.| |.
rtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
PTPc_DSPc_SM00012 343-445 2.4e-35 116.3 In-house 4-104 (105) alignment 
Range on Protein: 343-445
Range on HMM: 4-104/105.0
HFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
|.|...|||||||.... .|..|..|.|...   ......||||||.||||||...||.|. ....    |.||..... .|.||.|.||||.|| |.||
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylflyr

AVQ
|..
all
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 291-444 4.4e-35 116.0 In-house 85-235 (237) alignment 
Range on Protein: 291-444
Range on HMM: 85-235/237.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIG
 || .|||...  .  ||.||.   .. ..|| .| . .|..   .| | .. ..| ||||.|||   . .| | ... .. .  ...|  |.|||||.|
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
||| |.||| .|   |.. .   .|||| .  . ..|  ..||. || |.....
rtgiflvidamlrqakekkv...vdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 291-452 6.3e-35 115.4 In-house 131-287 (290) alignment 
Range on Protein: 291-452
Range on HMM: 131-287/290.0
NKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIG
.||  ||||..||.  | .... ..|... .|  |.... .|.  .... . ......|...|   .|. .|  .. ..|.|   .  .||.||||...|
vkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk.rgntsivvHCSdtvg

RTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
|...|..... .|  |. |    ||... ..  |.|. |.|||. ||..... | .|.....
rsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 292-449 7.5e-35 115.3 In-house 128-278 (315) alignment 
Range on Protein: 292-449
Range on HMM: 128-278/315.0
KCCRYWPD-ANTKKDTGVITVTHISEQSMADYDLREFSMSHKdfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqeTFPDAGSIIVHCSAGIG
|| .||||      . | | |. .| .. .|   |.. . .    |||| .  |.|. |||.||. . | .|.....|  .    ..  |..||||||.|
kcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks...eesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvG

RTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
||| .| || ... ||.      .|..|... .|..|  ||||| .| |.| ||. .. 
rtGvvisidevvaqikrtr...svdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRN_pd Subfamily PTPRN 289-449 3.1e-34 113.0 In-house 138-293 (297) alignment 
Range on Protein: 289-449
Range on HMM: 138-293/297.0
AINKCCRYWPDANTkKDTGVITVTHISEQSM-ADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSA
 ...| |||||  . .  ..  |  .||     || .| | .   .  .|.| .  ||| |||..|||. .  .|.| . |||       . .|.||||.
gvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsd

GIGRTGTFIVIDIILNLIKQhGLdCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
| ||||..|.||..|| ... |.  ||||  |.  .|.||.|||.|..|..|.. || . ..
GaGrtGvyilidlvlnrllk.Gv.keidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 291-457 2.6e-33 110.4 In-house 131-293 (297) alignment 
Range on Protein: 291-457
Range on HMM: 131-293/297.0
NKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPS--DPSRVLNFLQDVNKKQETFPDAgSIIVHCSAG
.|| |||.|  ...  | ..|.  | ..   .  ||..... . .   | .  ..| .|||. |.   . | .|.....|.|. ..  ..  ..|||.||
kkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaG

IGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAA
.|||| .. || ..  .|.   . |.||..... .||.|  ||||. |||||| ||  .. .  .|. |
vGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
0041856 (Phosphotyrosine protein) phosphatases II 264-449 3.3e-32 106.9 In-house 1-172 (182) alignment 
Range on Protein: 264-449
Range on HMM: 1-172/182.0
NKSKNRYKNILPYNIKV-------------------------------DQLDS-------NCVAINkCCRYWPdantkkdtgvitvthiseqsmadydlr
|..||||..||||.                                  | |.          | .. ...|||                           
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywp...........................

efsmshkdfPEESRPMFHFHFKSWPDHGVPSdPSRVLNFLQDVNKkqetfpDAGSIIVHCSAGIGRTGTFIVIDIILNLikqhgldcEIDIYNTIRLVRQ
          .. |  ..... .|||||||. .. .|.|...|..      . | ..||||||.|||||........ |        .........|||.
.........ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl........gvsleeavklvrs

QRSGLVQTEAQYKFVYRAVQHYIE
.|.| |.|. || |...|. ....
rRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 291-453 6.5e-32 105.6 In-house 126-283 (287) alignment 
Range on Protein: 291-453
Range on HMM: 126-283/287.0
NKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIG
..| .|||. ..    |  ... ..|. .|.|  |.. . .|.  .. . .  ... .|...|  ..|  .|  ... .|.|   .  .||.||||...|
evcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk.rgntsivvhCsdtvG

RTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQ
|...|. ... .|  |. |    ||... ..  |.|. | ||| .||||.. .|..|... . 
rsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_PTPN14_pd Subfamily PTPN14 291-449 1.2e-31 104.8 In-house 133-297 (300) alignment 
Range on Protein: 291-449
Range on HMM: 133-297/300.0
NKCCRYWPDANTKKDTG---VITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPD-------AGS
.|. .|.|. . ||.|       ||    ..   .  . . . |    .| | ..|. .. |||||||.|..  |..|..|.  .. . .          
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

IIVHCSAGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
..||||||.||||  |. |.... ...   . |||| .... .|.||  |||| |||||||... .|..
vlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 291-444 1.4e-31 104.5 In-house 91-236 (239) alignment 
Range on Protein: 291-444
Range on HMM: 91-236/239.0
NKCCRYWPDANTKKDTgvITVTHISEQSMADYDLREFSMSHKDFPEEsRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqETFPDAGSIIVHCSAGIG
.|| .||||. .|     . ||    . .||| .| | ||.    || | ....||  |||.|||   . || . . . |  ...| |   ..|||||.|
kkchqywpdstskycn..lrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvg

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|||.|.||| .|   |.   .  .||.| .. .|..|  .|||  || |.. ||
rtgaflvidamlrqakk...qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 291-444 1.6e-31 104.3 In-house 92-237 (239) alignment 
Range on Protein: 291-444
Range on HMM: 92-237/239.0
NKCCRYWPDANTKKDTgvITVTHISEQSMADYDLREFSMSHKDFPEEsRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqETFPDAGSIIVHCSAGIG
.|| .||||. .|     . ||    . .||| .| | ||.    || | ....||  |||.|||   . || . . . |  ...| |   ..|||||.|
kkchqywpdstskycn..lrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvg

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|||.|.||| .|   |.   .  .||.| .. .|..|  .|||  || |.. ||
rtgaflvidamlrqakk...qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN23_pd Subfamily PTPN23 291-454 3.7e-31 103.0 In-house 123-286 (288) alignment 
Range on Protein: 291-454
Range on HMM: 123-286/288.0
NKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKK--QETFPDAGSIIVHCSA
.|. |||| .. . .  | ..||  |....  .  |.......| ... . . | ...|||..|||. |. .|.||. |...  ..  .    ..|||||
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.adavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsa

GIGRTGTFIV-IDIILNLIKQHGLDceiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQR
|.||||.| . . .. .| |..||    || . .. .|.||   ||...|.||.| || ....   ..
GvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 292-448 4.7e-30 99.4 In-house 127-279 (439) alignment 
Range on Protein: 292-448
Range on HMM: 127-279/439.0
KCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSM-SHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIG
.  .|||  . .   | |.|    .  . .| .| | .  ..|  |  | ...||. .|||. ||.. | ||.||. .|  ...  . | ..||||||.|
esykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvG

RTGTFIVIDIILNLIKqhgLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|||| | .|| |. .|   |. ..||   ....|.||  .||. .|| |.| ||   |
rtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0043147 (Phosphotyrosine protein) phosphatases II 302-442 5.4e-30 99.8 In-house 42-155 (172) alignment 
Range on Protein: 302-442
Range on HMM: 42-155/172.0
TKKDTGVITVTHIseqsmadydlrefsmsHKDFPEESRPMFHFHFKSWPDHGVPsDPSRVLNFLQDVNKKQeTFPDAGSIIVHCSAGIGRTGTFIVIDII
... | ....|                   .| . ..|  ..... .||||||| ... .|.||. .....    . | ..||||||.|||||.......
elgithivnltel................lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylm

LnlikqhgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
|         . ........|||..|.| ||.. ||.|.| 
l.........lglsleeavalvrekRpgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 284-441 5.9e-30 99.6 In-house 45-163 (174) alignment 
Range on Protein: 284-441
Range on HMM: 45-163/174.0
DSNCVAINKCCRYWPDantkkdtgvitvthiseqsmadydlrefsmshkDFPEESRPMFHFHFKSWPDHGVPSDPSrVLNFLQDVNKKQETfPDAGSIIV
...   . ||..|||.                                 .   ..|  .....  |||||||...  .|.|.. |.. ..  .. | ..|
eekelglykcinywpe.................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlV

HCSAGIGRTGTFIVIDIILNLIKqhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVY
|||||.|||||.......| ...       .|.....| .|.||.| |||. ||.|.|
HCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 291-448 1e-28 95.4 In-house 130-288 (325) alignment 
Range on Protein: 291-448
Range on HMM: 130-288/325.0
NKCCRYWPDA-NTKKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPD----AGSIIVHC
..|. |||.     |  | . |  .. . ..||  | . .   .   |.| .  |...||.| ||.  |. ....|| |.. .|.       .. |.|||
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SAGIGRTGTFIVIDIILNlikQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|||.||||.|| .  .|.   .   . ..||.. .. .|..|  .|.|  || ..| |.  ..
saGvGrtGvfislysala...kvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
SH2 SH2 domain 112-187 1.4e-28 89.4 Pfam-A 1-77 (77) alignment 
Range on Protein: 112-187
Range on HMM: 1-77/77.0
WFHGHITGKEAEKSLVDKGKNGSYLVRESHSKPGDYVLSVRTEDKVTHVMIRCQDTK-YDVGGGEQFETLTDLVDHY
|.||.|...|||. | ...|.|..|||||.||||||.|||....||.|. |...... | . ..|.|..|..||.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 290-450 1.8e-28 94.1 In-house 124-295 (301) alignment 
Range on Protein: 290-450
Range on HMM: 124-295/301.0
INKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFS--------------MSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQET
 .|| .|||..... .. | .||| ..|| . |. .|...              . ...   .|. .  ..  .||..||  .|  ||. ..|| ..|  
kskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk

fPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
 .. | ..||||....|.|... ..| |   |  |    .|... .. ||... | |.|  || ..| ... |.. 
.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
0046846 (Phosphotyrosine protein) phosphatases II 293-448 9.2e-28 92.6 In-house 65-173 (176) alignment 
Range on Protein: 293-448
Range on HMM: 65-173/176.0
CCRYWPDantKKDTGVitvthiseqsmadydlrefsmshkdfpeesrpmfHFHFKSWPDHGVPSDpSRVLNFLQDVNKKQETfpDaGSIIVHCSAGIGRT
|..|||.    .. |.                                  ....  |||||||.. . .|..|. ... ..   . | ..||||||||||
cpnywpe...leklgi..................................qylhlpwpDhgvpdl.elllellefirealke..g.gpvlVHCsaGigRt

GTFIVIDIILNlikqhglDCEIDIYNTIRLVRQQRS-GLVQTEAQYKFVYRAVQHYI
||.......         .. ........|||.||. | |||..||.|.|.......
gtlvaayllel.......ekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 231-445 1.1e-27 91.4 In-house 15-233 (392) alignment 
Range on Protein: 231-445
Range on HMM: 15-233/392.0
ENSKKAGFEEEFEALqllDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQL---DSNCVAINKCCRYWPDANTKKdtGVITVTHISEQSMADY-----
.| . | | |||  |    . .. |.... |  |. ||||||||||.    .|   |           | |  ...|    |.       |. |.     
knrhsalffeefhdl...pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek..ayiasqgpnaaslddfwrmvf

--DLREFSMSHK----DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDagSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDI
  .    .|  |    |  .. | .  |||  |||..||   | .|.|...|. .   .     .|.|||||.||||  | || ..   |.  .   .|.
qenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgvvisidsvvahakktrm...vdv

YNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
.| .  .|..|  .|||. || |.| || 
fnfvtnirrkrpymvqtkeqyafiygavl
0048076 (Phosphotyrosine protein) phosphatases II 314-447 6.6e-27 89.4 In-house 36-142 (145) alignment 
Range on Protein: 314-447
Range on HMM: 36-142/145.0
IseqsmadydlrefsmsHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDaGSIIVHCSAGIGRTGTFIVIDIILNlikqhgldCE
.                  ... ..|  ..... .|||||||.... .|.||. ... ..   . | ..||||||.|||||.......|         . 
l................tselellerlgiqylylpwpDhgvpdllellleflefieealke..g.gpvlVHCsaGvgRtgtlvaaylmll........lg

IDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHY
........|||.||.| |... |..|.|......
vsleealelvrsqrpgavpnpgqlrflyefelel
0049772 (Phosphotyrosine protein) phosphatases II 256-451 7.6e-27 90.3 In-house 38-283 (314) alignment 
Range on Protein: 256-451
Range on HMM: 38-283/314.0
RKIGDKAENKSKNRYKNILPYNiKVDQL-----------------------------------------------------DSNCVAINK----------
....|. .|..||||..|||..    .|                                                     | |.  | .          
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------CCRYWPDAntkkdtGVITVTHISEQSmadydlrefsmS----HKDFpeeSRPMFHFHFKSWPDHGVPsDPSRVLNFLQDVNKKqetfPD
            .. ..        .  |. .. .             .    ...|   .|. ....   .||...| ... .. ||. ...     ..
srLdaAlgKtpllildgng......neptaadlellk...........eelydpelf...erlgikylripvpDgsap.lledfdeflefieea....dk

AGSIIVHCSAGIGRTGTFIVIDIilnLIKQHGldceIDIYNTIRLVRQQRS-----GLVQTEAQYKFVYRAVQHYIETL
 | ..|||.||.||||||.|...   |.|..|    ...  ... ||..|.     |....  || |...|...|...|
ggpvlvHCkaGkgRtgtfvvaay...lmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
SH2 SH2 domain 6-81 8.9e-27 83.6 Pfam-A 1-77 (77) alignment 
Range on Protein: 6-81
Range on HMM: 1-77/77.0
WFHPNISGMEAEQLLLNNGFDGCFLCRPSKSNPGDFTLSVRRNGEVTHIKIQNTGDF-FDLYGGEKFATLAELVQHY
|.| .||. |||.|||... || || |.|.|.|||.||||...|.|.|..||.. .  . . ..||| .|.|||.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
0049260 (Phosphotyrosine protein) phosphatases II 292-441 1.9e-26 88.0 In-house 50-143 (152) alignment 
Range on Protein: 292-441
Range on HMM: 50-143/152.0
KCCRYWpdantkkdtgvitvthiseqsmadydlrefsmshkdfpeesrpmfHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqeTFPDAGSIIVHCSAGIGR
|| .|.                                             ....  |||||||...  .| .|. ..|      . | ..||||||.||
kceqyi.............................................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgR

TGTFIVIDIILnlikqhgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVY
|||.......|         . ........|||..|.| |... |..|.|
tgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_CG7180_pd Subfamily CG7180 292-449 4.6e-26 86.1 In-house 125-291 (296) alignment 
Range on Protein: 292-449
Range on HMM: 125-291/296.0
KCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMSHK---------DFPEESRPMFHFHFKSWPD-HGVPSDPSRVLNFLQDVNKKQETF---PDA
..  |||    |.. | | |  ..|...|.   |.| . .|         .   | | . .|... |.  . ||.  . ...... |.. .|     |. 
mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

GSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
| ..|..| | .|.| .. ||. |.|.....   |.|... .. .|..| .||..  .||..|  ..... 
gPvvvvssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
0048179 (Phosphotyrosine protein) phosphatases II 332-442 6.4e-26 86.2 In-house 40-139 (144) alignment 
Range on Protein: 332-442
Range on HMM: 40-139/144.0
KDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfpDAGSIIVHCSAGIGRTGTFIVIDIILnlikqhglDCEIDIYNTIRLVRQQRSGLV
 . ... |. ..... .|||||||.... .|.||. ... .|   . | ..||||||.|||||........         . ........|||..|.| |
yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpgav

QTEAQYKFVYR
... |..|...
pnpgqlrfLle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 290-452 6.1e-25 82.9 In-house 121-281 (307) alignment 
Range on Protein: 290-452
Range on HMM: 121-281/307.0
INKCCRYWPDANTKKDT-----GVITVTHISEQSMA-DYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPdagsIIV
  || .|||  . .| .       |.|. .  . .| | || . .  . |. ..|| . |. .. |||.|||      .|.|. |. ...  |    ..|
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn..p....vvv

HCSAGIGRTGTFIVIDIILNLIKQhGLDCEiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
|||||.||.|| . | .. . . . | .|  |. . .. .|.||   .|||||| ...| . .|   | 
hcsaGvGrsGtivaislvqdkmia.Ginck.dmkklveelrsqrhyaiqteaqylylhrvlleyflely
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 290-453 6.1e-24 79.3 In-house 119-282 (287) alignment 
Range on Protein: 290-453
Range on HMM: 119-282/287.0
INKCCRYWPDANTKKDTGVITVTHISEQS-MADYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQE---TFPDAGSIIVHC
 .|| .|||. .     |  .|. .. .    .|  | . . . .  .|.| .  ... ||||....     .. |  ||... |      ..| ..||.
rlkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQ
..||||.|... . ....  .. |   ..|. ...  .|..| .|||.  |....| |.  | .|  |
dvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyyktnpq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 291-445 3.3e-23 76.8 In-house 134-280 (290) alignment 
Range on Protein: 291-445
Range on HMM: 134-280/290.0
NKCCRYWPDANTKKDT-GVITVTHIS-EQSMADYDLREFSMSHKDFPEeSRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqetfpdAGSIIVHCSAG
 || .|.|. . .  | | |||.    ..  |.  .. .|. .||    .  . |.. |||||. |.     .|  |. . |       .| ..||||||
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaG

IGRTGTFIVIDIILNLIKQhGldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|||||||. |.. |... . |   |.|. ...| .|. | . || . ||  . ... 
iGrtGtfvaievglqilld.G..keldlldlvralrnsrlnsvqvdiqylalveill
0051082 (Phosphotyrosine protein) phosphatases II 323-443 4.7e-23 76.9 In-house 39-148 (151) alignment 
Range on Protein: 323-443
Range on HMM: 39-148/151.0
DLREFS---MSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqetfPDAGSIIVHCSAGIGRTGTFIVIDIILnlIKqhgldceIDIYNT
.||.     . .. .||...  .|... .|||.|.|  .  ||.||. ...     .. | ..||||||.|||||.......|   .       .... .
nlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleea

IRLVRQQRSGLVQTEAQYKFVYRA
.. .|..| |.||.. |. |...|
leeyrlkrpgvvqpnqqflfqlfa
0044763 (Phosphotyrosine protein) phosphatases II 289-447 6.5e-23 76.7 In-house 62-170 (178) alignment 
Range on Protein: 289-447
Range on HMM: 62-170/178.0
AINKCCRYWPDANTkkdtgvitvthiseqsmadydlrefsmshkdfpeesrpmFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPDAGSIIVHCSAG
  .||..|||. .                                        .....  .||||||. .. .|.|.. ... ..  .. | ..||||||
gflkcdpywpeeag.......................................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaG

IGRTGTFIVIDIILNLikqhgldcEIDIYNTIRLVRQQRSgLVQTEAQYKFVYRAVQHY
.||.||........ |         ..... |.|||..|.  |... |....|.  ...
vgRsgtlvaaylmkkl........glsleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 337-448 1e-22 75.1 In-house 87-194 (440) alignment 
Range on Protein: 337-448
Range on HMM: 87-194/440.0
ESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQ
||| . ..|...|||.|||   . ||...||||. ||     | ..|||||| ||||  |..| ||   |.     .|||.. |  .|..|  .|||  |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrs...dqidifsfinsmrnnrpqmvqtpeq

YKFVYRAVQHYI
| ||. || . .
yafvheavlegl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 291-445 2.5e-22 74.1 In-house 115-263 (283) alignment 
Range on Protein: 291-445
Range on HMM: 115-263/283.0
NKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWpdhgVPSDPSRVLNFL---QDVNKKQETFPdAGSIIVHCSA
 ||..|||   . .| |  |||   | .   .  .|. . ..   ...  . |. .  |    .  ..  ..| |     |  .|   .  | |.||||.
ikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqtesk.kgPivvhCst

GIGRTGTFIVIDIilnLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|||||..|| .      .|.   .  .|...... .|.|| ..|||  |||.|. .| 
giGrtavfiaasa...svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 281-456 2.5e-20 67.3 In-house 122-298 (305) alignment 
Range on Protein: 281-456
Range on HMM: 122-298/305.0
DQLDSNCVAI----NKCCRYWPDANTKKDT--GVITVTHISEQSMADYDL-REFSMSHKDF-PEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQ
.|.   | ..     ||..||| |. .| .  . | |  .|     . |   . .. .  .  ...  . |...  ||| |||      |..|  .   .
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk

etFPdagsIIVHCSAGIGRTGTFIVIDIILNLIKQHgLDCEiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHY-IETLSQRVA
   |    |.|||||||||||| . |. ||. | .   .|   . . .. .|.||.  .|.. || |..| .  | .|   .. |
..vp....ivvhcsagigrtgtivaieyilekiaen.kpcp.pmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 290-451 2.7e-20 67.5 In-house 108-262 (267) alignment 
Range on Protein: 290-451
Range on HMM: 108-262/267.0
INKCCRYWPDA-NTKKDTGVITVTHISEQSMADYDLREFSMSHKDfpEESRPMFHFHFKSWPdhgVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAG
...  ..||      |    .|| |  |.   ||..  . .  |.  | .. .  ...| |    . ..    |. |  .  |..       ..|.||.|
tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdG

IGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
.||.|||.|||  |. .|. |     ||.. .| .|.|| |||.|  .| .... . .| |  
vGrsGtflvidsqleraktegv...sdifdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 336-449 5.9e-20 66.2 In-house 183-288 (305) alignment 
Range on Protein: 336-449
Range on HMM: 183-288/305.0
EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDvnkkqeTFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQ-HGLDceiDIYNTIRLVRQQRSGLVQTE
|..| . |.|.  ||| |||.    .|..|..      . |  | |.|||||||||||. .... ||. . . . ..   |    .. .|.||   .||.
ekarkvthyhwidwpdrgvpaadlailellek......arpskgpivvhcsagigrtgsvvmleyildqllagqiie...dtdkilqkireqrnnsiqtd

AQYKFVYRAVQHYIE
||| ||.. .  |..
aqylfvhqvilnyfr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 341-448 4e-18 60.2 In-house 217-344 (350) alignment 
Range on Protein: 341-448
Range on HMM: 217-344/350.0
MFHFHFKSWPDHGVPSDPSRVLNFLQ------DVNK-KQE-TFPDAGSIIVHCSAGIGRTGTFIVIDIILN------LIKQHGLDCEI------DIYNTI
......| |.| ..  .|  .|. |.      | .  ..      . .|.||||||.|||||.. .| .|.       ....    .        |  ..
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RLVRQQRSGLVQTEAQYKFVYRAVQHYI
  .|.||  .||.  |. |.| |...| 
nelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 336-448 1.4e-17 58.7 In-house 168-271 (288) alignment 
Range on Protein: 336-448
Range on HMM: 168-271/288.0
EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVnkKQETFPdagsIIVHCSAGIGRTGTFIVIDIILNLIKqhgLDCEIDIYNTIRLVRQQRSGLVQTEA
||.  . . |.. |.|.||| .    |..|. .  |. . |    |.||.|||.|||||.|.| |.|. ..   ||  . | . .   |..|   .||| 
eekvivkilhlleWdddgvPenylsplrllevl..kslqkP....ivvhssaGvGrtgtlililialeslr...lddflgirsllaklreerfkaiqtem

QYKFVYRAVQHYI
|| .|.| | ...
qylyvhrcvleel
subfamily_PTPN6_pd Subfamily PTPN6 209-277 1.5e-17 58.6 In-house 2-67 (306) alignment 
Range on Protein: 209-277
Range on HMM: 2-67/306.0
TRISASGIRNRVEVLEKetkSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYN
|.. |. |..||. |||   ..|. .|||||||||.||  ..|.|| || |.|.|||.|||||||||..
tsllakeieqrvselek...eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfD
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 332-477 2.1e-17 57.8 In-house 170-305 (312) alignment 
Range on Protein: 332-477
Range on HMM: 170-305/312.0
KDFPEESRpMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqetfpDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLV
|   .||. . |. . ||||||.|      | .|  |.|      |   .| |||||.|||||...|. ..  ...       .. ..  |.|..|.  |
katgqesk.lnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmiaalrhp...rkqnvkdsfvllrkdrarsv

QTEAQYKFVYRAVQHYIETLSQRVAAEQNTLKTGREYINTKRAHYE
.. .|| .. |.| ... . .     ||.  |    | . |  . .
rvfpqyvyalrcvleflyskglykrneqewtkfketyakikakklk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 336-441 5.1e-17 56.3 In-house 185-281 (302) alignment 
Range on Protein: 336-441
Range on HMM: 185-281/302.0
EESRPMFHFHFKSWPDHGVPSDPSRVLNFLqdvnKKQETFPDagSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEA
.  ...  ..| .||||| | ..   |. |    |  |..    ...||||||.|||||.. |   ..| ...      |. . .  ||| | | ||.| 
kvkktvdilafsawpdhGapkeaytaldil....kfcesykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqdeq

QYKFVY
|  .. 
qliyll
subfamily_CG42327_pd Subfamily CG42327 376-450 1.2e-15 52.0 In-house 245-317 (319) alignment 
Range on Protein: 376-450
Range on HMM: 245-317/319.0
PDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
 . | ..|||| |.||||. |  || .. ...      .|| ...  ||..|.  |.|  ||.|.|. .. | . 
esqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 289-448 1.6e-15 51.8 In-house 113-270 (285) alignment 
Range on Protein: 289-448
Range on HMM: 113-270/285.0
AINKCCRYWPDAN---TKKDTGVITVTHISEQSMADYDLREFSMS-HKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetfPDAGSIIVH
 ..||. |.|.      |     ||.|   |...|   |  ...   .|   |   | | .   |||.  | |   .... . |.| .   |    | ||
gvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvh

CSAGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
||||.||| ||. ||     | .   . .|.. . .| .|  |   ||.  |. |.|  .  |.
csagvgrtatfvgidyatirime...npniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 294-442 1.2e-14 49.0 In-house 48-198 (199) alignment 
Range on Protein: 294-442
Range on HMM: 48-198/199.0
CRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHK-DFPEESRPMFHFHFKSWPDHGVPSDPSRVlNF---LQDVNKKQETFPDAgSIIVHCSAG
  ||| ...     | ..||  .  . .|| .  . .. .   |  .| . |. | || ..  |     |  |    ..| || |   ||  .||||| |
pfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfv.gfvvasrevskkyeqekda.pvivhcsdg

IGRTGTFIVIDIILNLiKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
 | || |. .|| .   ..      .|...  . .|| | |.. .  .|.|.|.
qgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 294-442 1.2e-14 49.0 In-house 47-197 (198) alignment 
Range on Protein: 294-442
Range on HMM: 47-197/198.0
CRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHK-DFPEESRPMFHFHFKSWPDHGVPSDPSRVlNF---LQDVNKKQETFPDAgSIIVHCSAG
  ||| ...     | ..||  .  . .|| .  . .. .   |  .| . |. | || ..  |     |  |    ..| || |   ||  .||||| |
pfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfv.gfvvasrevskkyeqekda.pvivhcsdg

IGRTGTFIVIDIILNLiKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
 | || |. .|| .   ..      .|...  . .|| | |.. .  .|.|.|.
qgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 289-452 2.1e-14 48.2 In-house 66-222 (255) alignment 
Range on Protein: 289-452
Range on HMM: 66-222/255.0
AINKCCRYWPDANTKKDTgVITVTHISEQSMADYDLREFSMSHKdFP--EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetfpdagSIIVHCS
...|| .|.|    .|   .  |. .. .|.||  ||   .  . .    . . . |...| |...  | ..  .|| |. | . .       |..||||
gvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitst.lgekkkthtvkhysykGWieknaPelareilnilkvvrdsk.......svvvhCs

AGIGRTGTFIVIDIILN-LIK--QHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIetlS
.||||. .|......   .|.  .     |.|  . .. .|..|.. ..|  |  |    |  ..    
tGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv...f
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 364-445 3.1e-14 47.5 In-house 215-292 (297) alignment 
Range on Protein: 364-445
Range on HMM: 215-292/297.0
FLQdVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDceiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
||| ..  .   |    ..||||||.||.|  .  |.||. .... .    |.   .. .|.||. ||||  |....| || 
flq.leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 291-440 7.9e-14 46.1 In-house 130-273 (301) alignment 
Range on Protein: 291-440
Range on HMM: 130-273/301.0
NKCCRYWPDAN-TKKDTGVITVTHISEQSMADYDLREFSMSHKDFPE--ESRPMFHFHFKSWPDHGVPSDPSRVLNFLQdVNKKQETfpdagSIIVHCSA
.||  | |     | | |  ...  ..... . .. . ..  .|  .  ..| . |. ...|.|.|||     . .... . || |       |.|||||
ekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek.....Pivvhcsa

GIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFV
||||. .||  ... . ..    | .|.. .... .|..|   |||. |  ..
GiGrsvafigteylarevea...dptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 289-468 1.3e-13 45.8 In-house 107-279 (290) alignment 
Range on Protein: 289-468
Range on HMM: 107-279/290.0
AIN--KCCRYWPDANT-KKDTGVITVTHISEQSMADYDLREFSMSHKDfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNkKQETfpdagSIIVHC
  .   | .| |..   .   . .||   |     | . ||  . . |  ||   . |  .|.| .  |. |.  .|. .| |. ...|      .||||
ntslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvk.askt.....pvivHc

SAGIGRTGTFIVIDIILNLIKQHGLdcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNTLKTGREY
  || |  ..  |..   .| .     .. . . .  .|.||  ..... .. ||  ..  ..    ...| |..  |.  |.
vdGiSrsAalaaiilgyQkiaetsg..svkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaee
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 333-446 1.5e-13 45.1 In-house 161-267 (281) alignment 
Range on Protein: 333-446
Range on HMM: 161-267/281.0
DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqETFPdagsiIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEID-IYNTIRLvrQQRSGLV
 .  |.| . |. .| |||  ||     .|. |. .  .  | |     ..|||||.||.||.. ..| |. |. |    .|  |   .|.    |.  |
syegetrlithwlwkewpdwqvpessevmlkilrkirar.stpp.....vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrv..tgraasv

QTEAQYKFVYRAVQH
||  || .... .  
qtlqqymliwkvlld
0038934 (Phosphotyrosine protein) phosphatases II 342-449 3.7e-13 45.0 In-house 80-178 (194) alignment 
Range on Protein: 342-449
Range on HMM: 80-178/194.0
FHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDaGSIIVHCSAGIGRTGTFIVIDIILNlikqHGLdceiDIYNTIRLVRQQRSGLVQTEAQYKFVY
....   .||.|.. . . .|.||. |... .  |. | . ||| ||.|||||...  .|      .|.    .    |.|.|. | | ...  ... ..
ieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaYLiyr....lgm....saeeAialfrekRpgaipnqdyleall

RAVQHYIE
. ......
krykelrk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 345-458 1.4e-12 41.7 In-house 187-295 (302) alignment 
Range on Protein: 345-458
Range on HMM: 187-295/302.0
HFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpDAgSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
... |... ||   ... .  ..| .|..   |. ....    |.|| |.|..  . .. ....    |  | .... .|.||.  |..  || ..|.|.
vltnWkqkkvpvkyaeliktaakvfakkika.de.ntvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyial

QHYIETLSQRVAAE
  || .  .. . .
llyikkkvtkpeek
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 382-444 3.8e-12 40.4 In-house 2-61 (69) alignment 
Range on Protein: 382-444
Range on HMM: 2-61/69.0
IVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
.||||.| ||||||| | . .  ||   |   .||.| .. .|. |  .|  | .| |.. |.
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 341-448 4.5e-12 40.0 In-house 220-344 (349) alignment 
Range on Protein: 341-448
Range on HMM: 220-344/349.0
MFHFHFKSWPDHGVPSDPSRVLNFLQ------DVNKKQETFP--DAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLD-CEI-------D-IYNTIRLV
.. . .| |.| ..  .|  .|. |.      | .  .  .   .  ...|||||| ||||... .|..|....    .   |       | |. ..  .
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnel

RQQRSGLVQTEAQYKFVYRAVQHYI
|.||  .||  ||. ..| |. .|.
rkqrismvqnlaqfiaiyealLkyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 291-365 4.6e-12 40.4 In-house 116-190 (297) alignment 
Range on Protein: 291-365
Range on HMM: 116-190/297.0
NKCCRYWPDANT-KKDTGVITVTHISEQSMAdYD---LREFSMSHKdfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFL
.||  |||...  .. .| . | ..|. |   .|   | |. . ..   .||| . |  | ||||||||||   .  | 
dkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 382-444 4.8e-12 40.1 In-house 1-60 (69) alignment 
Range on Protein: 382-444
Range on HMM: 1-60/69.0
IVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
.||||.| ||||||| | . .  ||   |   .||.| .. .|. |  .|  | .| |.. |.
vvhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdal
subfamily_eak_pd Subfamily eak 363-463 1.2e-11 38.6 In-house 221-320 (332) alignment 
Range on Protein: 363-463
Range on HMM: 221-320/332.0
NFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGlDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNTL
. |. . ||    | . . |. .. |  |.|.|.|||....|| ..       . . |  |...|   | .. |. |.| .| .|. .  .|.   .. |
allsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkk.knlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyl

K
.
e
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 291-447 3e-11 37.5 In-house 134-289 (310) alignment 
Range on Protein: 291-447
Range on HMM: 134-289/310.0
NKCCRYWPDANTKKDTGVITVTHISEQSmADYDLREFSMS--HKDFPEESRPMF-------HFHFKSWPDHGVPSDPSRVlnflqdVNKKQETFPDAGSI
 ||  |||     .  |.| || .|| |  .... .....    . | . .|           ..  ||| ||| .          | ..  .    |  
pkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht......vpqrllaqvrhgpc

IVHCSAGIGRTGTFIVIDIILNLIkQHGLDceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHY
.||||||..|... . ... .. . ..||   .|. . .  ....|   .||| || .. |    .
vvhcsagkdrlyvvvalklkidkl.drglk..vdaeevktellksraiciqtelqyliidrvriif
subfamily_PTPDC1_pd Subfamily PTPDC1 327-446 5.4e-11 37.3 In-house 71-174 (182) alignment 
Range on Protein: 327-446
Range on HMM: 71-174/182.0
FSMSHKDFPEESrpMFHFHFkSWPDHGVPSdpsrvLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILnlikQHGLDCEidiyNTIRLVRQQ
|| . ... |.   .... | .|.|.||.|     |. . |. |  .   . | . ||| || ||||  |   ..     .. |. |    ..|.|||..
fsYdlealmeqg..iyvynf.gwkDygvas.....leriLdivkvvafalqegkvavhChaGlGrtGvliacylvy....akrltae....kaiklvrsk

RSGLVQTEAQYKFVYRAVQH
|.  .||  | ..|    ..
rpksiqtreqvelvkefalf
subfamily_ptpA1_pd Subfamily ptpA1 333-403 1.3e-10 35.6 In-house 180-254 (418) alignment 
Range on Protein: 333-403
Range on HMM: 180-254/418.0
DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQE-TFPDA---GSIIVHCSAGIGRTGTFIVIDIILN
 |  |.| . ..... |||| .|     . ..|. . ..|.   | .     ||||||||.||||||    |...
tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_hpo-7_pd Subfamily hpo-7 289-446 6.2e-10 33.4 In-house 72-225 (263) alignment 
Range on Protein: 289-446
Range on HMM: 72-225/263.0
AINKCCRYWPDANTKK-DTGVITVTHISEQSmaDYDLREFSMSH--KDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetfpdagSIIVHC
...|| .|.|    .|     ..|.    ||  |  |.   .    ..   . . . |. .| |...  | ..  .|| |. . . .       |..|||
gvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekndpelareilnilkvarnsk.......slvvhc

SAGIGRTGTFIVIDIILN-LIK--QHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQH
|.||||.  | |....   .|.  .     |.|  . .. .|..|.. ..|  |  |    |  
stGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_egg_pd Subfamily egg 285-449 1.2e-09 32.3 In-house 120-271 (307) alignment 
Range on Protein: 285-449
Range on HMM: 120-271/307.0
SncvaiNKCCRYWPDANTKKDT---GVITVTHISEQSMADYDlreFSMSHKDF---PEESRPMFHFHFkSWPDHGVPSDPSRVLNFLQDVNKkqetfPda
|     ..|  ||| |...      | . .. .  .| ||     | ...       .| | . |.    .   .    | |||  |... |     |  
s.....erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk.....p..

gsIIVHCSAGIGRTGTFIVIDIIL-NLIKqhGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
  ..|..  |. ...|.. |.| | .|..  |      . ... ..|..|   |..  .| |||| |  .. 
..vvvqdilGvskaatlvaieiallsllr..Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 228-283 6.8e-09 30.2 In-house 13-66 (288) alignment 
Range on Protein: 228-283
Range on HMM: 13-66/288.0
KSRENSKKAGFEEEFEALQLLDNKHllPRKIGDKAENKSKNRYKNILPYNIKVDQL
.  . ....||.||...|  |....    ..| .|.|..||||.|||||. |  .|
akksarnrtgfseeynsLaalektk..svtagrlavnakknRyrnilpyDekrvkl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 323-448 1.3e-08 28.9 In-house 158-279 (303) alignment 
Range on Protein: 323-448
Range on HMM: 158-279/303.0
DLREFSMSHKDFpeesRP-MFHFHFKSWPDHGVPSD-PSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIIlnLIKQHGLDCEIDIYNTI
 |.  |.|  |.    .  .   |.|.||   .|||  ..... . ...     . |.   .    .| ||.||| ...     .  |  .  .|. . .
vlkvlsvsngdy....ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta..hlslhseqasldlvkcl

RLVRQQRSGLVQTEAQYKFVYRAVQHYI
  ||. |   ||  .|. .||  .  ..
envrngrlhavqnlsqfsvvytllaehv
subfamily_DSP23_pd Subfamily DSP23 335-442 2.2e-08 28.9 In-house 45-140 (148) alignment 
Range on Protein: 335-442
Range on HMM: 45-140/148.0
PEESRPMFHFHFKSWPDHGvPSDPSRVLNFLQDVNKKQETfpdAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQTE
. |. |   ..    .|.  |  . .| .|.. |.. .|    . .. |||  | |||||..       |.|...|       ..|  ||..| | |.| 
hveatpnltlvrlriddyh.ppaleqvvefvrvveeaeek...neavsvhcllgrgrtgtmlac....ylvkerklaaa....eaiaevrrlrpgsvetv

AQYKFVYR
 | | |. 
eqeklvrd
subfamily_CG42327_pd Subfamily CG42327 286-370 3e-08 27.7 In-house 107-192 (319) alignment 
Range on Protein: 286-370
Range on HMM: 107-192/319.0
NCVAINKCCRYWPDANTKKDT---GVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFkSWPDHGVPSDPSRVLNFLQDVNK
    |..| .|.|  .| ..|   | | ||    ..   | .  . . . |  ||||.. |. .  |.. .||.... ..  | .|..
selGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvd.keesrelthywy.kwleaevPaeeaaliamllevrs
PTEN_1 338-440 6.1e-08 27.7 In-house 92-185 (196) alignment 
Range on Protein: 338-440
Range on HMM: 92-185/196.0
SRPMFHFHFkSWPDHGVPSdPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIvidiILNLIKQHGldceIDIYNTIRLVRQQR-SGLVQTEAQ
 . . . || ...|||.||  |... .. ..       |. . ..||| ||.||.|| .    .  |.. ..     .  ....|||..|  | ...  |
ksgveylhf.pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk....ltadeAlelvrekRppgapnspsq

YKFV
 ...
erll
subfamily_CDC14_pd Subfamily CDC14 351-441 9.7e-08 26.2 In-house 243-317 (328) alignment 
Range on Protein: 351-441
Range on HMM: 243-317/328.0
DHGVPSDpSRVLNFLQDVNKKqetfpdAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQTEaQYKFVY
| ..||| . | .||. ..|        |.|.||| ||.|||||.|       |.|....  .    ..|  .|  | | | .  | ||..
DGstPsd.aivkkfleiaeka......eGaiavhCkaGLGrtGtLiac....ylmkhyrftaa....eaiawlricrPGsvigp.qqkfle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 283-439 2.8e-07 24.3 In-house 140-293 (332) alignment 
Range on Protein: 283-439
Range on HMM: 140-293/332.0
LDSNCVAINKCCRYWPDANTKKDTGVITVTHISEQSMADydLREFSMSHKDFPEESRpMFHFHFKSWPDHGV-PSD--PSRVLNFLQDVNKKQETFPDAG
|.   .  . | ..||. ..|||  ....    ..| .   .. | ..  .  .. .    .||  | |    |      |    || .   ..|    |
leecelkakicrkfwpekrskkdfpalsiqasddhseth..mktfnltvtekkqdhq.tvlmhfyewadasklpeymldmrasiklqyirsskktgvcig

SIIVHCSAGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKF
 |.. |..|. .   .  ||||.. | .   .  . . .|.  .. || | ..|   |  
pimlvcatgvekcaisatidiivsrite...ehrvgfketmsaikmqrfgcfrtvgpyst
subfamily_PTPRG_pd Subfamily PTPRG 224-277 3.2e-07 23.9 In-house 7-60 (563) alignment 
Range on Protein: 224-277
Range on HMM: 7-60/563.0
EKETKSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYN
.|   |   . . ||.|||||||   ... |. .  .| ||| |||| ||..|.
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivayd
0048567 (Phosphotyrosine protein) phosphatases II 327-398 3.3e-07 24.8 In-house 16-97 (157) alignment 
Range on Protein: 327-398
Range on HMM: 16-97/157.0
FSMSHKDFPEESRPMFHF-------HFKSWPDHGvPSDPSRVLNFLQDVNKKQETFP-DAGSIIVHCSAGI---GRTGTFIVI
. ..    |.    ...|       ..  . |.| | . ... .| . .||. . .    . |.|||.||    |||.|.|  
yfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_PTPRB_pd Subfamily PTPRB 221-281 6.1e-07 23.8 In-house 10-68 (293) alignment 
Range on Protein: 221-281
Range on HMM: 10-68/293.0
EVLEKETKSRENSKKAGFEEEFEALQLLDNKHllPRKIGDKAENKSKNRYKNILPYNIKVD
| .|.  |. ..  ...| ||.| |.......    |. ..|.|..||||.|||||.    
ekfeehvkkmkadsdlrfseeyeelkavgkdq..avkaaelavnraknrytnilpydhsrv
subfamily_PTPRD_pd Subfamily PTPRD 208-278 7.5e-07 23.2 In-house 285-352 (564) alignment 
Range on Protein: 208-278
Range on HMM: 285-352/564.0
ATRISASGIRNRVEVLEKETksrENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYNI
 | .... ...... |.. .   |... .|.| ||. |.  ....|   . ..| .|| |||. |||... 
ntevesenlkqhlqkLaeve...edtemtgleleFqrLatakeieleefavatkpknkkknrfsnilales
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 220-277 9.8e-07 23.1 In-house 7-61 (319) alignment 
Range on Protein: 220-277
Range on HMM: 7-61/319.0
VEVLEKETKSRENSKKAGFEEEFEALQLLDNKhllPRKIGDKAENKSKNRYKNILPYN
|. |....|  ... . ..|.||. |.  .|.     .  .| |||.||||.|||.|.
vqeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilayd
subfamily_PTEN_pd Subfamily PTEN 351-441 1.3e-06 23.5 In-house 89-173 (184) alignment 
Range on Protein: 351-441
Range on HMM: 89-173/184.0
DHGVPSdPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDcEIDIYNTIRLVRQqrSGlVQTEAQYKFVY
||  |.  . . ....|..|  |.  .   ..||| || ||||. ||  .. .|. ..  .  .......|   .  .| |.  .| ..|.
Dhnppp.lelleeivediekwlee.dkknvvvvHCkaGkGRtGvlivayllkslllekaee.alelfaeaRtknk..kg.vtiPsqrRYve
PTPc_motif_SM00404 359-427 1.3e-06 23.4 In-house 67-121 (140) alignment 
Range on Protein: 359-427
Range on HMM: 67-121/140.0
SRVLNFLQDVnkkqetFPDAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQR
..||.|....        . |...||| ||. |..|.|.      |.....|. .    . ...|...|
dkvldfiena......ekkggkvlVHCqaGvSRSatliia....Ylmryrqlsla....eayefvkerR
subfamily_PTPN12_pd Subfamily PTPN12 231-279 1.5e-06 22.3 In-house 3-55 (290) alignment 
Range on Protein: 231-279
Range on HMM: 3-55/290.0
ENSKKAGFEEEFEALQLLDNK----HLLPRKIGDKAENKSKNRYKNILPYNIK
|.. .. |..||..|. | .|    .  ... |.| ||. |||||.||||. .
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydks
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 373-449 1.5e-06 21.0 In-house 238-310 (346) alignment 
Range on Protein: 373-449
Range on HMM: 238-310/346.0
ETFPDAGSIIVhCSAGIGRTGTFIVIdiiLNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
. . .||  .|    | ||. .||     |  |.|     | .|.. .. ..||| | |.. |||  .|  |  || 
kqvqnagvcvv.slfgcgracsfiga...lyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
subfamily_Ptp69D_pd Subfamily Ptp69D 221-277 1.8e-06 22.3 In-house 7-61 (307) alignment 
Range on Protein: 221-277
Range on HMM: 7-61/307.0
EVLEKETKSRENSKKAGFEEEFEALQLLdnKHLLPRKIGDKAENKSKNRYKNILPYN
. ||.. |||..  . |...|.| |.    .  .  |...| ||. ||||..| ...
ddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafD
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 346-450 1.9e-06 21.6 In-house 234-340 (347) alignment 
Range on Protein: 346-450
Range on HMM: 234-340/347.0
FKSWPDHGVPSDPSRVLNFLQDVNKKQETF-----PDAGSIIVHCSAGIGRTGTFIVIDIILNL-IKQHGLDCEidiyNTIRLVRQQRSGLVQTEAQYKF
  .|| .  | |  .|| ...   |.  |           ..| |  |. |. | ..  ||..  .. .  ||.    . .. .|.||.|.      | .
cttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcd....dlfkkmrdqragvftmsifyty

VYRAVQHYIET
  ||   |.  
airaalfylkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 221-278 2.6e-06 21.9 In-house 12-70 (298) alignment 
Range on Protein: 221-278
Range on HMM: 12-70/298.0
EVLEKETKSRENSKKAGFEEEFEALQLLDN-KHLLPRKIGDKAENKSKNRYKNILPYNI
. |.| .. ... | .|...||. |.   .  .    ... | |||.|||| .|.... 
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialds
subfamily_PTPRA_pd Subfamily PTPRA 220-278 4.4e-06 20.8 In-house 16-72 (330) alignment 
Range on Protein: 220-278
Range on HMM: 16-72/330.0
VEVLEKETKSRENSKKAGFEEEFEALQLLDNKHLLprKIGDKAENKSKNRYKNILPYNI
|| ||.| . |       | |||.||   . .  |  .. .| ||| |||. |||||. 
vekleeeirirsaddnklfreefnalPagpiqatl..elaskeenkeknrvvnilPydf
DSPc Dual specificity phosphatase, catalytic domain 360-432 5.4e-06 21.3 Pfam-A 61-119 (133) alignment 
Range on Protein: 360-432
Range on HMM: 61-119/133.0
RVLNFLQDVnkkqetFPDAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQ
.. .|....        . ....||| ||| |..|.|.      |.|...|. .    . ...|...|| ...
eavefieka......eqkgkkvlVHCqaGisRSatliia....Ylmktknlsln....eAyefvkerrskisp
DSPc Dual specificity phosphatase, catalytic domain 360-432 5.4e-06 21.3 In-house 61-119 (133) alignment 
Range on Protein: 360-432
Range on HMM: 61-119/133.0
RVLNFLQDVnkkqetFPDAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQ
.. .|....        . ....||| ||| |..|.|.      |.|...|. .    . ...|...|| ...
eavefieka......eqkgkkvlVHCqaGisRSatliia....Ylmktknlsln....eAyefvkerrskisp
subfamily_PTPN13_pd Subfamily PTPN13 238-286 5.7e-06 20.8 In-house 13-59 (273) alignment 
Range on Protein: 238-286
Range on HMM: 13-59/273.0
FEEEFEALQLLdnKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSN
 .|||. |. |  | |.  ..| |.|||.||||.|.|||.    .|...
Paeefkelrel..kpldtcevgkkkenkdknryrnvlPydetrvklgde
subfamily_CDKN3_pd Subfamily CDKN3 345-452 9.1e-06 19.4 In-house 103-200 (202) alignment 
Range on Protein: 345-452
Range on HMM: 103-200/202.0
HFKSWPDHGVPsDPSRVLNFLQDVNKKQETfpdAGSIIVHCSAGIGRTGtfIVIDIILNLikqhgLDCEIDIYNTIRLVRQQR-SGLVQTEAQYKFVYRA
|    .| .|| |..  |..|....   ..       .|||  |.||.   .||  .| .     ||  |.  ..|  .|. . |. .||  || ..   
hhypiadglvp.diasclkileelrinlka...yrktlvhcygglgrss..lviacllly.....lddtiepkdaidklrdlkgsraiqtvkqynylsef

VQHYIETLS
 ..  | ||
rdkleeyls