Gene PTPN6-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP065_AA protein Get Run
SpurP065_AA_220-449 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 290-454 2.2e-81 268.2 In-house 137-302 (306) alignment
Range on Protein: 290-454
Range on HMM: 137-302/306.0
INKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFP--DAGSIIVHCSA
 .||.|||||...|...|.|.||..||.|.|||.|||.|.|.|.. .|.| .|..|||||||||||.||. ||.||.|||.|||..   .||.|.|||||
kekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsa

GIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETlSQR
|||||||||||||.|.||...|||..|||......||.|||||||||.||||||.|...|||| ...
GiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet.kkk

0046845 (Phosphotyrosine protein) phosphatases II 237-451 3.8e-64 212.1 In-house 1-277 (284) alignment
Range on Protein: 237-451
Range on HMM: 1-277/284.0
GFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYNIK-------------VDQLDSNCVAI---------------------------------
|.|||||.|. |  |.||..... . ||.||||||.||||.                |  . . |                                   
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

----------------NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQET
                .||..|||. ....  | .||| .||. . || .|...........||| . |||..||||||||..|. .|.||..|.. .| 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
.|. | |.||||||.|||||||..|..|......||....|...... .|.|| | |||..||.|||.|...|. ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0050432 (Phosphotyrosine protein) phosphatases II 222-452 2.2e-61 203.2 In-house 30-303 (308) alignment
Range on Protein: 222-452
Range on HMM: 30-303/308.0
VLEKETKSreNSKKAGFEEEFEALQLLDNkhLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSN-----------------CVAI--------------
 | |  ..     . ..|||||.|. . .  ||..... . |||.|||||.||||      ||..                 .  |              
dllkllek..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFw

----------------------NKCCRYWPDA--NTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQ
                      .||..|||.   .. .  | .|||..||....|| .|.. ..... . ||| . |||...|||||||..|. .|.||.
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldfle

DVNKKQetfPDaGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
 |.|..   |. | |.||||||.|||||||..|..|......   ...|...... .|.|| | |||. ||.|.|||...|.... 
lvrksl...pg.gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0045450 (Phosphotyrosine protein) phosphatases II 221-448 1.3e-60 201.1 In-house 12-304 (307) alignment
Range on Protein: 221-448
Range on HMM: 12-304/307.0
EVLEKETKSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDS-------------NCV-------------------
..|... . .  . ..|...||| |. .  ..| ...|. . |||.|||||.||||.    .| |             . |                   
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

---------------------------------AINKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVP
                                 . .||..|||| ....  | .||| .||. ...| .| . ....|. .|||   |||...|||||||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

SDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
.... .|.|.. |.| .|. |. | ..||||||.|||||||.....| .....|  . .|......|.|.||.| ||.. ||.|.|.|.....
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0051299 (Phosphotyrosine protein) phosphatases II 223-448 5.3e-60 198.7 In-house 17-286 (288) alignment
Range on Protein: 223-448
Range on HMM: 17-286/288.0
LEketksreNSKKAGFEEEFEALQLLDNKhlLPRKIGDKAENKSKNRYKNILPYNIKVDQLDS------------NCVAI--------------------
|         . ..|..||||.|. |  .  |..... . ||..||||..||||.    .| .            . . .                    
ll.......angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

------------------------NKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHKD---FPEESRPMFHFHFKSWPDHGVPSDPSRVLN
                        .||..|||. ....  | |||| .||....|| .|.. ....|   ...|||   |||...|||||||..|. .|.
FWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

FLQDVNKKQEtfPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
||..|.|...  .. | ..||||||.|||||||..|..|......    ..|...... .|.|| |.|||. ||.|||.|. .|.
flrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 228-451 7.4e-59 194.8 In-house 5-280 (297) alignment
Range on Protein: 228-451
Range on HMM: 5-280/297.0
KSRENSKKAGFEEEFEALqlLDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSNC----------------------------------------
.... . .|....||| |  |....| ..... . ||..|||||.||||.    .||..                                         
llekllflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

------------VAINKCCRYWPDA-NTKKDTGVITVTHISEQS--MADYDLREFSMSHKDFPeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQ
               .||..|||.  .  .  | .||| .|...   .|| ||.. ..... . ||| . |||...|||||||..|. .|.|.. |.|..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvl

ETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
. .|. | ..||||||.||.||||..|..|......   ...||..... .|.|| | |||. ||.|.|.|..... . 
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

subfamily_PTPRD_pd Subfamily PTPRD 291-461 1.4e-58 193.9 In-house 131-294 (564) alignment
Range on Protein: 291-461
Range on HMM: 131-294/564.0
NKCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMsHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPDAGSIIVHCSAGIG
.|| .|||. . ..  | .|||  .|. .||| .|.|.. .|   .|||   .||| ||||||||  .  .|.....|.. .|  |||| |.||||||.|
vkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVG

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNT
|||||||||..|. ||.   .  .|||......|.||  .|||| || |...|......  .. | .|. .
RTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlk

0047943 (Phosphotyrosine protein) phosphatases II 232-448 6e-58 191.8 In-house 8-272 (273) alignment
Range on Protein: 232-448
Range on HMM: 8-272/273.0
NSKKAGFEEEFEALqlLDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQL-----------------------------------------DSNCVA-
 . .....||||.|  |..|.||..... . |||.|||||.||||.     |                                         . |.   
llgltllleefell..lslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

----------INKCCRYWPDANT--KKDTGVITVTHISEQSMADYDLREFSMSHKDFPEeSRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPD
           .||..|||. .   ..  | .|||..||.. .|| .|.. .......| || . |||...|||||||.... .|.|...|.|..|..|.
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealps

AGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
 | ..||||||.|||||||..|..|.... .|   ..|......|.|.|| | |||. ||.|.|.|. .|.
ngpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0040438 (Phosphotyrosine protein) phosphatases II 232-455 1.6e-57 190.6 In-house 14-283 (317) alignment
Range on Protein: 232-455
Range on HMM: 14-283/317.0
NSKKAGFEEEFEALQLLDNKhllPRKIGDKAENKSKNRYKNILPYNIKVD-----------------------------------------------QLD
.| . ...|||| |. |.     ..... . |||.||||..||||                                                    ...
ksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

SNCV---------AINKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHKdFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtf
....           .||..|||. ....  | .|||..||. .|.. ||.. ....   .||| . |||...|||||||..|. .|.||. |....|  
vtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..

PDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRV
.. | ..||||||.|||||||.....|......|   ..|...... .|.||.| |||..||.|.|.|...|. .  ...
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle

0043336 (Phosphotyrosine protein) phosphatases II 233-448 1.5e-54 180.7 In-house 17-277 (278) alignment
Range on Protein: 233-448
Range on HMM: 17-277/278.0
SKKAGFEEEFEALqlLDNKHlLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSNC---------------------------------------------
. |.....||| |  |..|.  ...|. . |||.|||||.||||. .  .|..                                               
nlktllllefeel..lsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

-----------VAINKCCRYWPdaNTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEEsRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfP
              .||..|||  .. .  | .||| ..|....|| .| . ....  .|. |   |.|...|||||||...| .|.||..|....|  .
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale..d

DAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
. | ..||||||.|||||||.....|.... .|   ..|...... .|.|| | |||. ||.|.|.|...|.
sngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 219-450 2.1e-54 180.4 In-house 15-291 (297) alignment
Range on Protein: 219-450
Range on HMM: 15-291/297.0
RVEVLEKETKSRENSKKAGFEEEFEALQLLDNkhllPRKIGDKAENKSKNRYKNILPYNIKVDQLDS---------------------------------
...||.   . .  ..| ....||| |. |      ...|. . |||.|||||.||||.    .| .                                 
plsvldlllllekansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

--------------NCV-----------AInKCCRYWPDANTkkDTGVITVTHISEQSMADYDLREFSMSHkdfPEESRPMFHFHFKSWPDHGVPSDPSR
              ..               ||..|||.  .    | .||| ....  ..| .|......    .||| . ||.. .|||||||.... 
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslel

VLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
.|.||. |.. ... |. | ..||||||.|||||||.....|.... .   ...|...... .|.||.| |||. ||.|.|.|..... .
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkr

0040439 (Phosphotyrosine protein) phosphatases II 257-448 1.3e-50 167.7 In-house 4-246 (249) alignment
Range on Protein: 257-448
Range on HMM: 4-246/249.0
KIGDKAENKSKNRYKNILPYNIKVDQLDS--------------------------------------------------------NCVAINKCCRYWPDa
... . |||.||||..||||.    .| .                                                             .||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

NTKKDTGVITVTHISEQSMADYDLREFSMSHKdFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDI
.. .  | .||| .|.....|| .|.. ....    |||   |... .|||||||.... .|.|.. |.| .|. |. | ..||||||.|||||||....
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
.|.... .   ...|......|.|.||.| ||.. ||.|.|.|.....
mleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 258-448 1.1e-49 164.6 In-house 4-242 (243) alignment
Range on Protein: 258-448
Range on HMM: 4-242/243.0
IGDKAENKSKNRYKNILPYNIKV------------------------------------------DQLDSNCVA---------INKCCRYWPdaNTKkDT
|. . ||.|||||..||||.                                              .|.....           .||..|||  ...   
iallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.ty

GVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQET------FPDAGSIIVHCSAGIGRTGTFIVIDI
| .||| .||....|| .|.......| ....|  .|.|. .|||||||..|. .|.||..|.. .|        .. | ..||||||.|||||.|....
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

ILNLIkqhgldcEIDIYNTIRLVRQQRSG-LVQTEAQYKFVYRAVQHYI
.| |.       ..|......|.|.||.|  |||. ||.|.|.|.....
mllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell

0045098 (Phosphotyrosine protein) phosphatases II 259-450 1.4e-48 161.0 In-house 28-274 (278) alignment
Range on Protein: 259-450
Range on HMM: 28-274/278.0
GDKAENKSKNRYKNILPYNIK-----------------------------------VDQLDSNCV---------AINKCCRYWPDaNTKKDTGVITVTHI
. . .|..|||||.||||.                                     . .|.....         . .||..|||. .  .  | .||| .
alylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtll

SEQSMADYDLREFSMSHK---DFPEESRPMFHFHFKSWPDHGVPSDP--SRVLNFLQDVNKKQE-----------TFPDAGSIIVHCSAGIGRTGTFIVI
||. . || || . . .    .   ||| ..|.|...||||||||.|  . .|..|. ... ..           .... | ..||||||.|||||....
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

DIILNLIkqhglDCEIDIYNTIRLVRQQRSG-LVQTEAQYKFVYRAVQHYIET
...| |.     .. .|...... .|.|| |  ||.. ||.|.|........ 
ylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 290-460 2.1e-48 160.0 In-house 128-292 (318) alignment
Range on Protein: 290-460
Range on HMM: 128-292/318.0
INKCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGI
 .|. ||||. ...   | ..|.  .| ...|| ||||......  |||| .  .|. ||||.|||.... .|.....|.| |.. ..|| |.||||||.
kakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk.sgagpivvhCsaGv

GRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQN
||||.||..||.|. ||. .|   .|...|.. .|.||  .|||| ||.|.| ... ....  . | |.. 
GrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdl

0042113 (Phosphotyrosine protein) phosphatases II 259-449 3.2e-48 159.7 In-house 4-244 (245) alignment
Range on Protein: 259-449
Range on HMM: 4-244/245.0
GDKAENKSKNRYKNILPYNIKVDQLDSNCV--------------------------------------------------------AINKCCRYWPDaNT
. . |||.||||..||||.    .| .                                                             .||..|||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

KKDTGVITVTHISEQSMADYDLREFSMSHkDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGRTGTFIVIDIIL
.. .| .||| .||....|| .|...... .   |||  .|.|. .|||||||.... .|.||. |.| ..  .. | ..||||||.|||||||.....|
sltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylml

NLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
.... .   .......... .|.||.| |||. ||.|.|.|......
eqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 292-455 4.4e-48 159.0 In-house 132-290 (319) alignment
Range on Protein: 292-455
Range on HMM: 132-290/319.0
KCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGR
|. .|||..| . . | ..||  .|. ..||  |.... .|    |.| ..||....||||.|| .   .|..|....| .|  ...| |.||||||.||
klkkywpeenfe.eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPivvhCsaGvGR

TGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRV
||||||.|..|. .|. |.   .|...|.. .| ||  .||...||||.| |. ...|. .  .
tGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdtei

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 291-458 1.9e-47 156.9 In-house 129-293 (305) alignment
Range on Protein: 291-458
Range on HMM: 129-293/305.0
NKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAG-SIIVHCSAG
.|| .|||.. |. |. | ..|.  ||....||  |....| .|  .||| . .... .|||||||  .. .|.....|.|.|.   | | ...||||||
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk..dkgvpllVhCsag

IGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAE
.||||.||..|| |. .|. .   ..|... .. .|..| ..||| .|| |.. |.. .|..    .  .
vgRtGvfiavdialerlkkEe...vvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigs

subfamily_PTPRB_pd Subfamily PTPRB 291-451 1.6e-46 153.7 In-house 134-288 (293) alignment
Range on Protein: 291-451
Range on HMM: 134-288/293.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHkdfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIG
 || .|||. ..    | |.|| ..|... |. .||.....    .|.| . ..||.||||||||.... .|.|.. |....|.  ... |.||||||.|
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
|||||| .| .|. |... .   .||. ..  .|..|  |||||.|| |....|...... 
RtGtfialdrllqaieeedy...vdifgivaelReeRnllvqtekqYifihqcvldllrkk

DSPc_SM00195 290-448 1.7e-46 154.1 In-house 108-262 (263) alignment
Range on Protein: 290-448
Range on HMM: 108-262/263.0
INKCCRYWPDA-NTKKDTGVITVTHISEQSMA-DYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpdAGSIIVHCSA
 .|| ||||.  ..|.. | |.|. ......  .. ||........  ||.| . ....|.|||||||.... ||..|. |.|...|    | |.|||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|.||||||..|||||. ....     .|| .... .|.|| |.|||..||.|.|.|. .||
GvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 290-448 1.7e-46 154.1 In-house 108-262 (263) alignment
Range on Protein: 290-448
Range on HMM: 108-262/263.0
INKCCRYWPDA-NTKKDTGVITVTHISEQSMA-DYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpdAGSIIVHCSA
 .|| ||||.  ..|.. | |.|. ......  .. ||........  ||.| . ....|.|||||||.... ||..|. |.|...|    | |.|||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|.||||||..|||||. ....     .|| .... .|.|| |.|||..||.|.|.|. .||
GvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN12_pd Subfamily PTPN12 291-451 9.5e-46 151.0 In-house 123-280 (290) alignment
Range on Protein: 291-451
Range on HMM: 123-280/290.0
NKCCRYWPDANTKKD-TGVITVTHISEQSMA-DYDLREFSMSHKdfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPDAGSIIVHCSAG
.|| ||||. . ..  .| ..|| ..|. .  |. .| . . ..   .||| .  ||...|||||||| ....|.....|.. ||   ..  ..||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaG

IGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
.||||| |.||.. .|.|.. .. |.|... .. .|.||. ||||. ||..||.|| ..... 
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 291-454 9.2e-45 148.1 In-house 139-296 (298) alignment
Range on Protein: 291-454
Range on HMM: 139-296/298.0
NKCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKDFPeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDaGSIIVHCSAGIG
 |. .|||| ...   | |||.  |....||.  |.. .|.|.   ..| . ..|| ||||.|||.  . ||..|..|...|.   .  ..||.||||.|
tkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagn.kpvivqCsaGvg

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQR
|.||||.|| .|. .|.   .  .|...... .|..| |.||||.||.|.| ||...... .. 
RsGtfiaidsvlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

Y_phosphatase Protein-tyrosine phosphatase 291-445 1e-44 148.1 Pfam-A 82-234 (235) alignment
Range on Protein: 291-445
Range on HMM: 82-234/235.0
NKCCRYWP-DANTKKDTGVITVTHI-SEQ-SMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetFPDAGSIIVHCSA
.|| .||| . .... .| |.|.   .|.  ...| ||......|. ..|.| . ..|...|||||||..|. .|.....|.|..   .. |...|||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|.||||||...||.|. .....    .|...... .|.|| |.||...||.|.|.|..
GvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 291-445 1e-44 148.1 In-house 82-234 (235) alignment
Range on Protein: 291-445
Range on HMM: 82-234/235.0
NKCCRYWP-DANTKKDTGVITVTHI-SEQ-SMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetFPDAGSIIVHCSA
.|| .||| . .... .| |.|.   .|.  ...| ||......|. ..|.| . ..|...|||||||..|. .|.....|.|..   .. |...|||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|.||||||...||.|. .....    .|...... .|.|| |.||...||.|.|.|..
GvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_PTPRA_pd Subfamily PTPRA 291-448 1.6e-43 143.9 In-house 141-295 (330) alignment
Range on Protein: 291-448
Range on HMM: 141-295/330.0
NKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMS-HKDFP--EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSA
.|| .||||  .    | |.|.   |. . || .|.| .    |    ..|| .  |||.|||| |||..|  .|..|. |.|...    ||.|.|||||
ekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq..sagpivvhcsa

GIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|.||||||||.| .|. .|  .    .|...... .|.||. .|||. ||.|.|.....| 
GvGrtGtfivldavlervkaer...kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPRK_pd Subfamily PTPRK 288-444 6.9e-43 141.6 In-house 123-273 (314) alignment
Range on Protein: 288-444
Range on HMM: 123-273/314.0
VAINKCCRYWPDANTKkdTGVITVTHISEQSMADYDLREFSMSH-KDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCS
|.  ||..|||.  ..   | | |. .. .  |..  | |.... .   || | . .|.| .||||.||     .|.... |.|.||   .|| |.||||
vgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCs

AGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|| |||||||.|||.|..|...|.   .|..|... .|.... .|.|| ||||.| ..
aGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_PTPN13_pd Subfamily PTPN13 292-450 2.1e-42 140.3 In-house 118-271 (273) alignment
Range on Protein: 292-450
Range on HMM: 118-271/273.0
KCCRYWPDANTKKDT--GVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfpDAGSIIVHCSAGI
|| ||||. . || .  . ..|. .  | . .. .|.. .....  .||| . |..| .|||||||| .  .|.|.. |.. |.   ||| |.|||||||
kchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse.sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGi

GRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
||.||.|.||..|.||..     |.|. ...| .|.|| |.|||. || |||.|. . ...
GrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 292-450 2.3e-42 140.0 In-house 125-278 (281) alignment
Range on Protein: 292-450
Range on HMM: 125-278/281.0
KCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDaGSIIVHCSAGIGR
|| ||||| |..   | .||....|.. | |  |.|......   |.| . ......|||||||.... .|.| ..|.| .|.  .  ....|||||.||
kChrYWPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGr

TGTFIVIDIILNLIKQHGldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
|||.| .| ... ....    |.|. .... .|..|  .||| .||.|||.|| .... 
tGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 291-449 3.3e-42 139.5 In-house 130-280 (288) alignment
Range on Protein: 291-449
Range on HMM: 130-280/288.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMShKDfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSAGIG
.|| .|||||...|  | .||| .... . |. ||.. .  |.  .. . . ......||||||| .   .|..|. |.  ..   |.| ||||||||.|
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kk..kteleitqyqylaWpdhgvPeskapllellrqvkvanqa..dtgpiivhCsaGvG

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
||||||..| ... ...   .  ||. .|.  .|.||  ||||. || |.|... . ||
rtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie

subfamily_PTPRG_pd Subfamily PTPRG 291-472 5e-42 138.9 In-house 131-312 (563) alignment
Range on Protein: 291-472
Range on HMM: 131-312/563.0
NKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSH---KDFPE--ESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVnkKQETFPDAGSIIVHC
.|| .|||  .. .. |...|| |.|. .| |  |.... .   |.. .  . . . ..|. .|||||||. .  ||.| .    .. .  .|| |.|||
rkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHc

SAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQ-NTLKTGREYINTK
|||.|||||.||.| .|. |.|.     ........ .| ||  ||||| || |.. |..  | .  . . ||| . ||    |.. .
saGvgrtGtyivldtllkqiqqen...avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyleqq

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 292-452 5.6e-42 138.7 In-house 92-246 (250) alignment
Range on Protein: 292-452
Range on HMM: 92-246/250.0
KCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGR
.. .|||  .. .  | .||.  |.. .|||  |.. .|..   ...| . ..|| .||| |||     ||..|..|...|.   ... .||.||||.||
tyhqywPveka.ekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgr

TGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
.|.||.|| .|. .|.   .  .|... |. .|..| . |....|| |||...........
sGafiaidavlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_PTPN9_pd Subfamily PTPN9 291-449 1e-40 134.6 In-house 125-291 (297) alignment
Range on Protein: 291-449
Range on HMM: 125-291/297.0
NKCCRYWP-DANTKKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETF-----------PDA
 || .||| . .. .. | ..|.... ... ||  | . ... .  |||| . || | ||||.||||. . .|..|. | .|| ..           |. 
lkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsg

GSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
  |.|||||||||||||| .|| |. ... |    .|. .|..|.|.||.  .||. ||.| | ||  |  
PPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavleyal

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 290-445 1.2e-40 134.7 In-house 137-288 (319) alignment
Range on Protein: 290-445
Range on HMM: 137-288/319.0
INKCCRYWPDA-NTKKDTGVITVTHISEQsmADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAG
 .||..|||   . |.. . . |. . |   |.| .|.. .|..   .. | .  |||. |||.|||  || .. ... |.. ..   .  .|.||||||
kdkcsqywplkivikeerfkvkvdsveet..aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
.||||..||.|..|. .|.   .  .|.||..| .||||. |||  .||||.| |. 
vGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 290-445 5.3e-40 132.7 In-house 101-252 (284) alignment
Range on Protein: 290-445
Range on HMM: 101-252/284.0
INKCCRYWPDA-NTKKDTGVITVTHISEQsmADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAG
 .||..|||   . |.. . . |. ..|   ..| .|.. .|..   .. | .  |||. |||.|||  || .. ... |.. ..   .  .|.||||||
kdkcsqywplkivikeerfkvkvdsvees..eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

IGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
.||||..||.|..|. .|.   .  .|.||..| .||||. |||  .||||.| |. 
vgrtgvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 291-451 5.9e-40 132.1 In-house 113-271 (274) alignment
Range on Protein: 291-451
Range on HMM: 113-271/274.0
NKCCRYWPDANTK---KDTGVITVTHISEQSMADYDLREFSMSHKDFpeeSRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDA-GSIIVHCS
.|| .|.|||.     .  | . ..  .  .  || .|......      .| . |. . .|||| .| |.. .|.....|....|.     ....||||
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCs

AGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
||||||| || |.| .. ...   .  .|. ...  .|..| |.|||. ||....||. .| . |
aGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 291-454 1.2e-39 130.9 In-house 104-270 (270) alignment
Range on Protein: 291-454
Range on HMM: 104-270/270.0
NKCCRYWPDANTK---KDTGVITVTHISEQSMADYDLREFSMSHKdfPEESRPMfHFHFKSWPDHGVPSDPS------RVLNFLQDVNKKQETFPDAGSI
.|| ||||  . .     .| |.|. .||. .  | |..  . .|   || | . ||....|||||||...        .|. |..| . .. . .|. .
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleek..geerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

IVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQR
.||||||.|||||.|..||...|.....   ..|. . |. .|..|  |||.  ||.|.|.||..|.|....|
lvHcsaGvgRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrakr

subfamily_PTPN1_pd Subfamily PTPN1 291-453 1.1e-38 127.6 In-house 111-276 (290) alignment
Range on Protein: 291-453
Range on HMM: 111-276/290.0
NKCCRYWPDANT----KKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCS
.|| .|||  .     . .   ..|. |||..   | .| . .  .   .|.| ..|||. .||| |||. |.  |.||..| .     .| |  ..|||
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQ
|||||.|||...| .| ||....    .|| ...  .|..| ||.||  | .| | |. . . .. .
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg

subfamily_Ptp69D_pd Subfamily Ptp69D 291-449 2.9e-38 126.7 In-house 131-287 (307) alignment
Range on Protein: 291-449
Range on HMM: 131-287/307.0
NKCCRYWPDAnTKKDTGVITVTHISEQSMADYDLREFSMSHKD--F--PEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpdAGSIIVHCS
.|| .|||.  ...  | | |. .||... ||  ||...|.|.      |.|| .  .|...|.|  ||  .  .|.... |.. ...    . |.||||
kkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCs

AGIGRTGTFIVIDIilnLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
|| ||.|.|. .|.   |..|  .. ..||..|.. .|.||. |||  .||.|.|||.  |..
aGvgrsgifvalds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPN3_pd Subfamily PTPN3 291-446 6.8e-38 125.2 In-house 124-273 (280) alignment
Range on Protein: 291-446
Range on HMM: 124-273/280.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDagSIIVHCSAGIG
 ||..|||. . . . | ..|.  .|..   | |||. ...|.  .|.|..... . .|||||||.|.. .|.|.. |.|....  .   ..||||||||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsgkee..PvvvhCsaGig

RTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQH
||| .|.... | || ..    .. . . .| .|.||. ||||..|||||  |. .
rtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfvCeailk

0051429 (Phosphotyrosine protein) phosphatases II 288-452 3.2e-37 124.0 In-house 58-229 (272) alignment
Range on Protein: 288-452
Range on HMM: 58-229/272.0
VAINKCCRYWP-----------DANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPsrVLNFLQDVNKkqetfp
.. .|| ||||           |. .    | ..||..||. . || |||. ....  ..|.| ..|.|. .|||||||...  .|..|. ...      
rgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......

dAGSIIVHCSAGIGRTGTFIVIDIILnliKQHGLDCEID--------IYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
  | ..||||||..||||.......|    . .|.. .|        ...... .|.|| | ||||.||.|.|.|.......| 
.ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 291-449 8.6e-36 118.1 In-house 126-277 (515) alignment
Range on Protein: 291-449
Range on HMM: 126-277/515.0
NKCCRYWPD--ANTkKDTGVITVTHISEQSMADYDLREFSMSHKDfpeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPdaGSIIVHCSAG
 || .||||  ...    | | |  .| .. ..   |.. . . |   .|| .  |||. |||.||| . | .| ....|  ... .    ..|.|||||
ikcgkyWPdkpgds.vkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaG

IGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
.|||| .| || ..  .|.      .|..|... .||.|  ||||. || |.| ||. .. 
vGrtGvvisidsvvahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 291-444 2.3e-35 117.0 In-house 132-275 (315) alignment
Range on Protein: 291-444
Range on HMM: 132-275/315.0
NKCCRYWPDAntKKDTGVITVTHISEQSMADYDLREFSMSHKDfpeESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSAGIG
.|. .||||   |   | ||||..||.   .|  | .|.  .|   . | .. .|. |||| |||     ..|. . |.. ...  ..|.|.||||||.|
rkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtn..svgaivvhcsaGvG

RTGTFIVIDIILNlikQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|||||| .| .|.   |   .  ||.|| |. |||.| ..||. .||.|.| |.
rtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

PTPc_DSPc_SM00012 343-445 2.4e-35 116.3 In-house 4-104 (105) alignment
Range on Protein: 343-445
Range on HMM: 4-104/105.0
HFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
|.|...|||||||.... .|..|..|.|...   ......||||||.||||||...||.|. ....    |.||..... .|.||.|.||||.|| |.||
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylflyr

AVQ
|..
all

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 291-444 4.4e-35 116.0 In-house 85-235 (237) alignment
Range on Protein: 291-444
Range on HMM: 85-235/237.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIG
 || .|||...  .  ||.||.   .. ..|| .| . .|..   .| | .. ..| ||||.|||   . .| | ... .. .  ...|  |.|||||.|
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
||| |.||| .|   |.. .   .|||| .  . ..|  ..||. || |.....
rtgiflvidamlrqakekkv...vdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 291-452 6.3e-35 115.4 In-house 131-287 (290) alignment
Range on Protein: 291-452
Range on HMM: 131-287/290.0
NKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIG
.||  ||||..||.  | .... ..|... .|  |.... .|.  .... . ......|...|   .|. .|  .. ..|.|   .  .||.||||...|
vkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk.rgntsivvHCSdtvg

RTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
|...|..... .|  |. |    ||... ..  |.|. |.|||. ||..... | .|.....
rsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 292-449 7.5e-35 115.3 In-house 128-278 (315) alignment
Range on Protein: 292-449
Range on HMM: 128-278/315.0
KCCRYWPD-ANTKKDTGVITVTHISEQSMADYDLREFSMSHKdfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqeTFPDAGSIIVHCSAGIG
|| .||||      . | | |. .| .. .|   |.. . .    |||| .  |.|. |||.||. . | .|.....|  .    ..  |..||||||.|
kcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks...eesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvG

RTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
||| .| || ... ||.      .|..|... .|..|  ||||| .| |.| ||. .. 
rtGvvisidevvaqikrtr...svdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPRN_pd Subfamily PTPRN 289-449 3.1e-34 113.0 In-house 138-293 (297) alignment
Range on Protein: 289-449
Range on HMM: 138-293/297.0
AINKCCRYWPDANTkKDTGVITVTHISEQSM-ADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDAGSIIVHCSA
 ...| |||||  . .  ..  |  .||     || .| | .   .  .|.| .  ||| |||..|||. .  .|.| . |||       . .|.||||.
gvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsd

GIGRTGTFIVIDIILNLIKQhGLdCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
| ||||..|.||..|| ... |.  ||||  |.  .|.||.|||.|..|..|.. || . ..
GaGrtGvyilidlvlnrllk.Gv.keidiaatlehlrdqrpglvktkdqfefaltavaeevn

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 291-457 2.6e-33 110.4 In-house 131-293 (297) alignment
Range on Protein: 291-457
Range on HMM: 131-293/297.0
NKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPS--DPSRVLNFLQDVNKKQETFPDAgSIIVHCSAG
.|| |||.|  ...  | ..|.  | ..   .  ||..... . .   | .  ..| .|||. |.   . | .|.....|.|. ..  ..  ..|||.||
kkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaG

IGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAA
.|||| .. || ..  .|.   . |.||..... .||.|  ||||. |||||| ||  .. .  .|. |
vGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa

0041856 (Phosphotyrosine protein) phosphatases II 264-449 3.3e-32 106.9 In-house 1-172 (182) alignment
Range on Protein: 264-449
Range on HMM: 1-172/182.0
NKSKNRYKNILPYNIKV-------------------------------DQLDS-------NCVAINkCCRYWPdantkkdtgvitvthiseqsmadydlr
|..||||..||||.                                  | |.          | .. ...|||                           
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywp...........................

efsmshkdfPEESRPMFHFHFKSWPDHGVPSdPSRVLNFLQDVNKkqetfpDAGSIIVHCSAGIGRTGTFIVIDIILNLikqhgldcEIDIYNTIRLVRQ
          .. |  ..... .|||||||. .. .|.|...|..      . | ..||||||.|||||........ |        .........|||.
.........ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl........gvsleeavklvrs

QRSGLVQTEAQYKFVYRAVQHYIE
.|.| |.|. || |...|. ....
rRpgmvitpnqyfflqlallelll

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 291-453 6.5e-32 105.6 In-house 126-283 (287) alignment
Range on Protein: 291-453
Range on HMM: 126-283/287.0
NKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIG
..| .|||. ..    |  ... ..|. .|.|  |.. . .|.  .. . .  ... .|...|  ..|  .|  ... .|.|   .  .||.||||...|
evcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk.rgntsivvhCsdtvG

RTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQ
|...|. ... .|  |. |    ||... ..  |.|. | ||| .||||.. .|..|... . 
rsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtveqykfindivleyldsfet

subfamily_PTPN14_pd Subfamily PTPN14 291-449 1.2e-31 104.8 In-house 133-297 (300) alignment
Range on Protein: 291-449
Range on HMM: 133-297/300.0
NKCCRYWPDANTKKDTG---VITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPD-------AGS
.|. .|.|. . ||.|       ||    ..   .  . . . |    .| | ..|. .. |||||||.|..  |..|..|.  .. . .          
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

IIVHCSAGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
..||||||.||||  |. |.... ...   . |||| .... .|.||  |||| |||||||... .|..
vlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 291-444 1.4e-31 104.5 In-house 91-236 (239) alignment
Range on Protein: 291-444
Range on HMM: 91-236/239.0
NKCCRYWPDANTKKDTgvITVTHISEQSMADYDLREFSMSHKDFPEEsRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqETFPDAGSIIVHCSAGIG
.|| .||||. .|     . ||    . .||| .| | ||.    || | ....||  |||.|||   . || . . . |  ...| |   ..|||||.|
kkchqywpdstskycn..lrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvg

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|||.|.||| .|   |.   .  .||.| .. .|..|  .|||  || |.. ||
rtgaflvidamlrqakk...qktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 291-444 1.6e-31 104.3 In-house 92-237 (239) alignment
Range on Protein: 291-444
Range on HMM: 92-237/239.0
NKCCRYWPDANTKKDTgvITVTHISEQSMADYDLREFSMSHKDFPEEsRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqETFPDAGSIIVHCSAGIG
.|| .||||. .|     . ||    . .||| .| | ||.    || | ....||  |||.|||   . || . . . |  ...| |   ..|||||.|
kkchqywpdstskycn..lrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvg

RTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
|||.|.||| .|   |.   .  .||.| .. .|..|  .|||  || |.. ||
rtgaflvidamlrqakk...qktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_PTPN23_pd Subfamily PTPN23 291-454 3.7e-31 103.0 In-house 123-286 (288) alignment
Range on Protein: 291-454
Range on HMM: 123-286/288.0
NKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKK--QETFPDAGSIIVHCSA
.|. |||| .. . .  | ..||  |....  .  |.......| ... . . | ...|||..|||. |. .|.||. |...  ..  .    ..|||||
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.adavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsa

GIGRTGTFIV-IDIILNLIKQHGLDceiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQR
|.||||.| . . .. .| |..||    || . .. .|.||   ||...|.||.| || ....   ..
GvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 292-448 4.7e-30 99.4 In-house 127-279 (439) alignment
Range on Protein: 292-448
Range on HMM: 127-279/439.0
KCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSM-SHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIG
.  .|||  . .   | |.|    .  . .| .| | .  ..|  |  | ...||. .|||. ||.. | ||.||. .|  ...  . | ..||||||.|
esykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvG

RTGTFIVIDIILNLIKqhgLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|||| | .|| |. .|   |. ..||   ....|.||  .||. .|| |.| ||   |
rtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

0043147 (Phosphotyrosine protein) phosphatases II 302-442 5.4e-30 99.8 In-house 42-155 (172) alignment
Range on Protein: 302-442
Range on HMM: 42-155/172.0
TKKDTGVITVTHIseqsmadydlrefsmsHKDFPEESRPMFHFHFKSWPDHGVPsDPSRVLNFLQDVNKKQeTFPDAGSIIVHCSAGIGRTGTFIVIDII
... | ....|                   .| . ..|  ..... .||||||| ... .|.||. .....    . | ..||||||.|||||.......
elgithivnltel................lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylm

LnlikqhgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
|         . ........|||..|.| ||.. ||.|.| 
l.........lglsleeavalvrekRpgavqnpsqyrflyy

0036282 (Phosphotyrosine protein) phosphatases II 284-441 5.9e-30 99.6 In-house 45-163 (174) alignment
Range on Protein: 284-441
Range on HMM: 45-163/174.0
DSNCVAINKCCRYWPDantkkdtgvitvthiseqsmadydlrefsmshkDFPEESRPMFHFHFKSWPDHGVPSDPSrVLNFLQDVNKKQETfPDAGSIIV
...   . ||..|||.                                 .   ..|  .....  |||||||...  .|.|.. |.. ..  .. | ..|
eekelglykcinywpe.................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlV

HCSAGIGRTGTFIVIDIILNLIKqhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVY
|||||.|||||.......| ...       .|.....| .|.||.| |||. ||.|.|
HCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrfly

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 291-448 1e-28 95.4 In-house 130-288 (325) alignment
Range on Protein: 291-448
Range on HMM: 130-288/325.0
NKCCRYWPDA-NTKKDTGVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPD----AGSIIVHC
..|. |||.     |  | . |  .. . ..||  | . .   .   |.| .  |...||.| ||.  |. ....|| |.. .|.       .. |.|||
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SAGIGRTGTFIVIDIILNlikQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
|||.||||.|| .  .|.   .   . ..||.. .. .|..|  .|.|  || ..| |.  ..
saGvGrtGvfislysala...kvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

SH2 SH2 domain 112-187 1.4e-28 89.4 Pfam-A 1-77 (77) alignment
Range on Protein: 112-187
Range on HMM: 1-77/77.0
WFHGHITGKEAEKSLVDKGKNGSYLVRESHSKPGDYVLSVRTEDKVTHVMIRCQDTK-YDVGGGEQFETLTDLVDHY
|.||.|...|||. | ...|.|..|||||.||||||.|||....||.|. |...... | . ..|.|..|..||.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 290-450 1.8e-28 94.1 In-house 124-295 (301) alignment
Range on Protein: 290-450
Range on HMM: 124-295/301.0
INKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFS--------------MSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQET
 .|| .|||..... .. | .||| ..|| . |. .|...              . ...   .|. .  ..  .||..||  .|  ||. ..|| ..|  
kskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk

fPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
 .. | ..||||....|.|... ..| |   |  |    .|... .. ||... | |.|  || ..| ... |.. 
.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

0046846 (Phosphotyrosine protein) phosphatases II 293-448 9.2e-28 92.6 In-house 65-173 (176) alignment
Range on Protein: 293-448
Range on HMM: 65-173/176.0
CCRYWPDantKKDTGVitvthiseqsmadydlrefsmshkdfpeesrpmfHFHFKSWPDHGVPSDpSRVLNFLQDVNKKQETfpDaGSIIVHCSAGIGRT
|..|||.    .. |.                                  ....  |||||||.. . .|..|. ... ..   . | ..||||||||||
cpnywpe...leklgi..................................qylhlpwpDhgvpdl.elllellefirealke..g.gpvlVHCsaGigRt

GTFIVIDIILNlikqhglDCEIDIYNTIRLVRQQRS-GLVQTEAQYKFVYRAVQHYI
||.......         .. ........|||.||. | |||..||.|.|.......
gtlvaayllel.......ekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 231-445 1.1e-27 91.4 In-house 15-233 (392) alignment
Range on Protein: 231-445
Range on HMM: 15-233/392.0
ENSKKAGFEEEFEALqllDNKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQL---DSNCVAINKCCRYWPDANTKKdtGVITVTHISEQSMADY-----
.| . | | |||  |    . .. |.... |  |. ||||||||||.    .|   |           | |  ...|    |.       |. |.     
knrhsalffeefhdl...pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek..ayiasqgpnaaslddfwrmvf

--DLREFSMSHK----DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDagSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDI
  .    .|  |    |  .. | .  |||  |||..||   | .|.|...|. .   .     .|.|||||.||||  | || ..   |.  .   .|.
qenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgvvisidsvvahakktrm...vdv

YNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
.| .  .|..|  .|||. || |.| || 
fnfvtnirrkrpymvqtkeqyafiygavl

0048076 (Phosphotyrosine protein) phosphatases II 314-447 6.6e-27 89.4 In-house 36-142 (145) alignment
Range on Protein: 314-447
Range on HMM: 36-142/145.0
IseqsmadydlrefsmsHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETfpDaGSIIVHCSAGIGRTGTFIVIDIILNlikqhgldCE
.                  ... ..|  ..... .|||||||.... .|.||. ... ..   . | ..||||||.|||||.......|         . 
l................tselellerlgiqylylpwpDhgvpdllellleflefieealke..g.gpvlVHCsaGvgRtgtlvaaylmll........lg

IDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHY
........|||.||.| |... |..|.|......
vsleealelvrsqrpgavpnpgqlrflyefelel

0049772 (Phosphotyrosine protein) phosphatases II 256-451 7.6e-27 90.3 In-house 38-283 (314) alignment
Range on Protein: 256-451
Range on HMM: 38-283/314.0
RKIGDKAENKSKNRYKNILPYNiKVDQL-----------------------------------------------------DSNCVAINK----------
....|. .|..||||..|||..    .|                                                     | |.  | .          
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------CCRYWPDAntkkdtGVITVTHISEQSmadydlrefsmS----HKDFpeeSRPMFHFHFKSWPDHGVPsDPSRVLNFLQDVNKKqetfPD
            .. ..        .  |. .. .             .    ...|   .|. ....   .||...| ... .. ||. ...     ..
srLdaAlgKtpllildgng......neptaadlellk...........eelydpelf...erlgikylripvpDgsap.lledfdeflefieea....dk

AGSIIVHCSAGIGRTGTFIVIDIilnLIKQHGldceIDIYNTIRLVRQQRS-----GLVQTEAQYKFVYRAVQHYIETL
 | ..|||.||.||||||.|...   |.|..|    ...  ... ||..|.     |....  || |...|...|...|
ggpvlvHCkaGkgRtgtfvvaay...lmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl

SH2 SH2 domain 6-81 8.9e-27 83.6 Pfam-A 1-77 (77) alignment
Range on Protein: 6-81
Range on HMM: 1-77/77.0
WFHPNISGMEAEQLLLNNGFDGCFLCRPSKSNPGDFTLSVRRNGEVTHIKIQNTGDF-FDLYGGEKFATLAELVQHY
|.| .||. |||.|||... || || |.|.|.|||.||||...|.|.|..||.. .  . . ..||| .|.|||.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

0049260 (Phosphotyrosine protein) phosphatases II 292-441 1.9e-26 88.0 In-house 50-143 (152) alignment
Range on Protein: 292-441
Range on HMM: 50-143/152.0
KCCRYWpdantkkdtgvitvthiseqsmadydlrefsmshkdfpeesrpmfHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqeTFPDAGSIIVHCSAGIGR
|| .|.                                             ....  |||||||...  .| .|. ..|      . | ..||||||.||
kceqyi.............................................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgR

TGTFIVIDIILnlikqhgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVY
|||.......|         . ........|||..|.| |... |..|.|
tgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_CG7180_pd Subfamily CG7180 292-449 4.6e-26 86.1 In-house 125-291 (296) alignment
Range on Protein: 292-449
Range on HMM: 125-291/296.0
KCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMSHK---------DFPEESRPMFHFHFKSWPD-HGVPSDPSRVLNFLQDVNKKQETF---PDA
..  |||    |.. | | |  ..|...|.   |.| . .|         .   | | . .|... |.  . ||.  . ...... |.. .|     |. 
mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

GSIIVHCSAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
| ..|..| | .|.| .. ||. |.|.....   |.|... .. .|..| .||..  .||..|  ..... 
gPvvvvssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

0048179 (Phosphotyrosine protein) phosphatases II 332-442 6.4e-26 86.2 In-house 40-139 (144) alignment
Range on Protein: 332-442
Range on HMM: 40-139/144.0
KDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfpDAGSIIVHCSAGIGRTGTFIVIDIILnlikqhglDCEIDIYNTIRLVRQQRSGLV
 . ... |. ..... .|||||||.... .|.||. ... .|   . | ..||||||.|||||........         . ........|||..|.| |
yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpgav

QTEAQYKFVYR
... |..|...
pnpgqlrfLle

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 290-452 6.1e-25 82.9 In-house 121-281 (307) alignment
Range on Protein: 290-452
Range on HMM: 121-281/307.0
INKCCRYWPDANTKKDT-----GVITVTHISEQSMA-DYDLREFSMSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPdagsIIV
  || .|||  . .| .       |.|. .  . .| | || . .  . |. ..|| . |. .. |||.|||      .|.|. |. ...  |    ..|
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn..p....vvv

HCSAGIGRTGTFIVIDIILNLIKQhGLDCEiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLS
|||||.||.|| . | .. . . . | .|  |. . .. .|.||   .|||||| ...| . .|   | 
hcsaGvGrsGtivaislvqdkmia.Ginck.dmkklveelrsqrhyaiqteaqylylhrvlleyflely

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 290-453 6.1e-24 79.3 In-house 119-282 (287) alignment
Range on Protein: 290-453
Range on HMM: 119-282/287.0
INKCCRYWPDANTKKDTGVITVTHISEQS-MADYDLREFSMSHKDFpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQE---TFPDAGSIIVHC
 .|| .|||. .     |  .|. .. .    .|  | . . . .  .|.| .  ... ||||....     .. |  ||... |      ..| ..||.
rlkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGIGRTGTFIVIDIILNLIKQHGldcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQ
..||||.|... . ....  .. |   ..|. ...  .|..| .|||.  |....| |.  | .|  |
dvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyyktnpq

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 291-445 3.3e-23 76.8 In-house 134-280 (290) alignment
Range on Protein: 291-445
Range on HMM: 134-280/290.0
NKCCRYWPDANTKKDT-GVITVTHIS-EQSMADYDLREFSMSHKDFPEeSRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqetfpdAGSIIVHCSAG
 || .|.|. . .  | | |||.    ..  |.  .. .|. .||    .  . |.. |||||. |.     .|  |. . |       .| ..||||||
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaG

IGRTGTFIVIDIILNLIKQhGldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|||||||. |.. |... . |   |.|. ...| .|. | . || . ||  . ... 
iGrtGtfvaievglqilld.G..keldlldlvralrnsrlnsvqvdiqylalveill

0051082 (Phosphotyrosine protein) phosphatases II 323-443 4.7e-23 76.9 In-house 39-148 (151) alignment
Range on Protein: 323-443
Range on HMM: 39-148/151.0
DLREFS---MSHKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqetfPDAGSIIVHCSAGIGRTGTFIVIDIILnlIKqhgldceIDIYNT
.||.     . .. .||...  .|... .|||.|.|  .  ||.||. ...     .. | ..||||||.|||||.......|   .       .... .
nlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleea

IRLVRQQRSGLVQTEAQYKFVYRA
.. .|..| |.||.. |. |...|
leeyrlkrpgvvqpnqqflfqlfa

0044763 (Phosphotyrosine protein) phosphatases II 289-447 6.5e-23 76.7 In-house 62-170 (178) alignment
Range on Protein: 289-447
Range on HMM: 62-170/178.0
AINKCCRYWPDANTkkdtgvitvthiseqsmadydlrefsmshkdfpeesrpmFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQEtfPDAGSIIVHCSAG
  .||..|||. .                                        .....  .||||||. .. .|.|.. ... ..  .. | ..||||||
gflkcdpywpeeag.......................................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaG

IGRTGTFIVIDIILNLikqhgldcEIDIYNTIRLVRQQRSgLVQTEAQYKFVYRAVQHY
.||.||........ |         ..... |.|||..|.  |... |....|.  ...
vgRsgtlvaaylmkkl........glsleeaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 337-448 1e-22 75.1 In-house 87-194 (440) alignment
Range on Protein: 337-448
Range on HMM: 87-194/440.0
ESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQ
||| . ..|...|||.|||   . ||...||||. ||     | ..|||||| ||||  |..| ||   |.     .|||.. |  .|..|  .|||  |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrs...dqidifsfinsmrnnrpqmvqtpeq

YKFVYRAVQHYI
| ||. || . .
yafvheavlegl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 291-445 2.5e-22 74.1 In-house 115-263 (283) alignment
Range on Protein: 291-445
Range on HMM: 115-263/283.0
NKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHKDFPEESRPMFHFHFKSWpdhgVPSDPSRVLNFL---QDVNKKQETFPdAGSIIVHCSA
 ||..|||   . .| |  |||   | .   .  .|. . ..   ...  . |. .  |    .  ..  ..| |     |  .|   .  | |.||||.
ikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqtesk.kgPivvhCst

GIGRTGTFIVIDIilnLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
|||||..|| .      .|.   .  .|...... .|.|| ..|||  |||.|. .| 
giGrtavfiaasa...svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 281-456 2.5e-20 67.3 In-house 122-298 (305) alignment
Range on Protein: 281-456
Range on HMM: 122-298/305.0
DQLDSNCVAI----NKCCRYWPDANTKKDT--GVITVTHISEQSMADYDL-REFSMSHKDF-PEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQ
.|.   | ..     ||..||| |. .| .  . | |  .|     . |   . .. .  .  ...  . |...  ||| |||      |..|  .   .
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk

etFPdagsIIVHCSAGIGRTGTFIVIDIILNLIKQHgLDCEiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHY-IETLSQRVA
   |    |.|||||||||||| . |. ||. | .   .|   . . .. .|.||.  .|.. || |..| .  | .|   .. |
..vp....ivvhcsagigrtgtivaieyilekiaen.kpcp.pmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 290-451 2.7e-20 67.5 In-house 108-262 (267) alignment
Range on Protein: 290-451
Range on HMM: 108-262/267.0
INKCCRYWPDA-NTKKDTGVITVTHISEQSMADYDLREFSMSHKDfpEESRPMFHFHFKSWPdhgVPSDPSRVLNFLQDVNKKQETFPDAGSIIVHCSAG
...  ..||      |    .|| |  |.   ||..  . .  |.  | .. .  ...| |    . ..    |. |  .  |..       ..|.||.|
tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdG

IGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETL
.||.|||.|||  |. .|. |     ||.. .| .|.|| |||.|  .| .... . .| |  
vGrsGtflvidsqleraktegv...sdifdflrkirsqriglvdtkeryiyihellaeyaegr

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 336-449 5.9e-20 66.2 In-house 183-288 (305) alignment
Range on Protein: 336-449
Range on HMM: 183-288/305.0
EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDvnkkqeTFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQ-HGLDceiDIYNTIRLVRQQRSGLVQTE
|..| . |.|.  ||| |||.    .|..|..      . |  | |.|||||||||||. .... ||. . . . ..   |    .. .|.||   .||.
ekarkvthyhwidwpdrgvpaadlailellek......arpskgpivvhcsagigrtgsvvmleyildqllagqiie...dtdkilqkireqrnnsiqtd

AQYKFVYRAVQHYIE
||| ||.. .  |..
aqylfvhqvilnyfr

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 341-448 4e-18 60.2 In-house 217-344 (350) alignment
Range on Protein: 341-448
Range on HMM: 217-344/350.0
MFHFHFKSWPDHGVPSDPSRVLNFLQ------DVNK-KQE-TFPDAGSIIVHCSAGIGRTGTFIVIDIILN------LIKQHGLDCEI------DIYNTI
......| |.| ..  .|  .|. |.      | .  ..      . .|.||||||.|||||.. .| .|.       ....    .        |  ..
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RLVRQQRSGLVQTEAQYKFVYRAVQHYI
  .|.||  .||.  |. |.| |...| 
nelrkqrismvqnldqfifiYeallfyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 336-448 1.4e-17 58.7 In-house 168-271 (288) alignment
Range on Protein: 336-448
Range on HMM: 168-271/288.0
EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVnkKQETFPdagsIIVHCSAGIGRTGTFIVIDIILNLIKqhgLDCEIDIYNTIRLVRQQRSGLVQTEA
||.  . . |.. |.|.||| .    |..|. .  |. . |    |.||.|||.|||||.|.| |.|. ..   ||  . | . .   |..|   .||| 
eekvivkilhlleWdddgvPenylsplrllevl..kslqkP....ivvhssaGvGrtgtlililialeslr...lddflgirsllaklreerfkaiqtem

QYKFVYRAVQHYI
|| .|.| | ...
qylyvhrcvleel

subfamily_PTPN6_pd Subfamily PTPN6 209-277 1.5e-17 58.6 In-house 2-67 (306) alignment
Range on Protein: 209-277
Range on HMM: 2-67/306.0
TRISASGIRNRVEVLEKetkSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYN
|.. |. |..||. |||   ..|. .|||||||||.||  ..|.|| || |.|.|||.|||||||||..
tsllakeieqrvselek...eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfD

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 332-477 2.1e-17 57.8 In-house 170-305 (312) alignment
Range on Protein: 332-477
Range on HMM: 170-305/312.0
KDFPEESRpMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKkqetfpDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLV
|   .||. . |. . ||||||.|      | .|  |.|      |   .| |||||.|||||...|. ..  ...       .. ..  |.|..|.  |
katgqesk.lnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmiaalrhp...rkqnvkdsfvllrkdrarsv

QTEAQYKFVYRAVQHYIETLSQRVAAEQNTLKTGREYINTKRAHYE
.. .|| .. |.| ... . .     ||.  |    | . |  . .
rvfpqyvyalrcvleflyskglykrneqewtkfketyakikakklk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 336-441 5.1e-17 56.3 In-house 185-281 (302) alignment
Range on Protein: 336-441
Range on HMM: 185-281/302.0
EESRPMFHFHFKSWPDHGVPSDPSRVLNFLqdvnKKQETFPDagSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEA
.  ...  ..| .||||| | ..   |. |    |  |..    ...||||||.|||||.. |   ..| ...      |. . .  ||| | | ||.| 
kvkktvdilafsawpdhGapkeaytaldil....kfcesykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqdeq

QYKFVY
|  .. 
qliyll

subfamily_CG42327_pd Subfamily CG42327 376-450 1.2e-15 52.0 In-house 245-317 (319) alignment
Range on Protein: 376-450
Range on HMM: 245-317/319.0
PDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIET
 . | ..|||| |.||||. |  || .. ...      .|| ...  ||..|.  |.|  ||.|.|. .. | . 
esqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 289-448 1.6e-15 51.8 In-house 113-270 (285) alignment
Range on Protein: 289-448
Range on HMM: 113-270/285.0
AINKCCRYWPDAN---TKKDTGVITVTHISEQSMADYDLREFSMS-HKDFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetfPDAGSIIVH
 ..||. |.|.      |     ||.|   |...|   |  ...   .|   |   | | .   |||.  | |   .... . |.| .   |    | ||
gvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvh

CSAGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYI
||||.||| ||. ||     | .   . .|.. . .| .|  |   ||.  |. |.|  .  |.
csagvgrtatfvgidyatirime...npniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 294-442 1.2e-14 49.0 In-house 48-198 (199) alignment
Range on Protein: 294-442
Range on HMM: 48-198/199.0
CRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHK-DFPEESRPMFHFHFKSWPDHGVPSDPSRVlNF---LQDVNKKQETFPDAgSIIVHCSAG
  ||| ...     | ..||  .  . .|| .  . .. .   |  .| . |. | || ..  |     |  |    ..| || |   ||  .||||| |
pfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfv.gfvvasrevskkyeqekda.pvivhcsdg

IGRTGTFIVIDIILNLiKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
 | || |. .|| .   ..      .|...  . .|| | |.. .  .|.|.|.
qgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 294-442 1.2e-14 49.0 In-house 47-197 (198) alignment
Range on Protein: 294-442
Range on HMM: 47-197/198.0
CRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHK-DFPEESRPMFHFHFKSWPDHGVPSDPSRVlNF---LQDVNKKQETFPDAgSIIVHCSAG
  ||| ...     | ..||  .  . .|| .  . .. .   |  .| . |. | || ..  |     |  |    ..| || |   ||  .||||| |
pfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfv.gfvvasrevskkyeqekda.pvivhcsdg

IGRTGTFIVIDIILNLiKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYR
 | || |. .|| .   ..      .|...  . .|| | |.. .  .|.|.|.
qgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 289-452 2.1e-14 48.2 In-house 66-222 (255) alignment
Range on Protein: 289-452
Range on HMM: 66-222/255.0
AINKCCRYWPDANTKKDTgVITVTHISEQSMADYDLREFSMSHKdFP--EESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetfpdagSIIVHCS
...|| .|.|    .|   .  |. .. .|.||  ||   .  . .    . . . |...| |...  | ..  .|| |. | . .       |..||||
gvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitst.lgekkkthtvkhysykGWieknaPelareilnilkvvrdsk.......svvvhCs

AGIGRTGTFIVIDIILN-LIK--QHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIetlS
.||||. .|......   .|.  .     |.|  . .. .|..|.. ..|  |  |    |  ..    
tGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv...f

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 364-445 3.1e-14 47.5 In-house 215-292 (297) alignment
Range on Protein: 364-445
Range on HMM: 215-292/297.0
FLQdVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDceiDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQ
||| ..  .   |    ..||||||.||.|  .  |.||. .... .    |.   .. .|.||. ||||  |....| || 
flq.leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 291-440 7.9e-14 46.1 In-house 130-273 (301) alignment
Range on Protein: 291-440
Range on HMM: 130-273/301.0
NKCCRYWPDAN-TKKDTGVITVTHISEQSMADYDLREFSMSHKDFPE--ESRPMFHFHFKSWPDHGVPSDPSRVLNFLQdVNKKQETfpdagSIIVHCSA
.||  | |     | | |  ...  ..... . .. . ..  .|  .  ..| . |. ...|.|.|||     . .... . || |       |.|||||
ekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek.....Pivvhcsa

GIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKFV
||||. .||  ... . ..    | .|.. .... .|..|   |||. |  ..
GiGrsvafigteylarevea...dptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 289-468 1.3e-13 45.8 In-house 107-279 (290) alignment
Range on Protein: 289-468
Range on HMM: 107-279/290.0
AIN--KCCRYWPDANT-KKDTGVITVTHISEQSMADYDLREFSMSHKDfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNkKQETfpdagSIIVHC
  .   | .| |..   .   . .||   |     | . ||  . . |  ||   . |  .|.| .  |. |.  .|. .| |. ...|      .||||
ntslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvk.askt.....pvivHc

SAGIGRTGTFIVIDIILNLIKQHGLdcEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNTLKTGREY
  || |  ..  |..   .| .     .. . . .  .|.||  ..... .. ||  ..  ..    ...| |..  |.  |.
vdGiSrsAalaaiilgyQkiaetsg..svkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaee

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 333-446 1.5e-13 45.1 In-house 161-267 (281) alignment
Range on Protein: 333-446
Range on HMM: 161-267/281.0
DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKqETFPdagsiIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEID-IYNTIRLvrQQRSGLV
 .  |.| . |. .| |||  ||     .|. |. .  .  | |     ..|||||.||.||.. ..| |. |. |    .|  |   .|.    |.  |
syegetrlithwlwkewpdwqvpessevmlkilrkirar.stpp.....vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrv..tgraasv

QTEAQYKFVYRAVQH
||  || .... .  
qtlqqymliwkvlld

0038934 (Phosphotyrosine protein) phosphatases II 342-449 3.7e-13 45.0 In-house 80-178 (194) alignment
Range on Protein: 342-449
Range on HMM: 80-178/194.0
FHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFPDaGSIIVHCSAGIGRTGTFIVIDIILNlikqHGLdceiDIYNTIRLVRQQRSGLVQTEAQYKFVY
....   .||.|.. . . .|.||. |... .  |. | . ||| ||.|||||...  .|      .|.    .    |.|.|. | | ...  ... ..
ieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaYLiyr....lgm....saeeAialfrekRpgaipnqdyleall

RAVQHYIE
. ......
krykelrk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 345-458 1.4e-12 41.7 In-house 187-295 (302) alignment
Range on Protein: 345-458
Range on HMM: 187-295/302.0
HFKSWPDHGVPSDPSRVLNFLQDVNKKQETFpDAgSIIVHCSAGIGRTGTFIVIDIILNLIKQHgldCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
... |... ||   ... .  ..| .|..   |. ....    |.|| |.|..  . .. ....    |  | .... .|.||.  |..  || ..|.|.
vltnWkqkkvpvkyaeliktaakvfakkika.de.ntvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyial

QHYIETLSQRVAAE
  || .  .. . .
llyikkkvtkpeek

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 382-444 3.8e-12 40.4 In-house 2-61 (69) alignment
Range on Protein: 382-444
Range on HMM: 2-61/69.0
IVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
.||||.| ||||||| | . .  ||   |   .||.| .. .|. |  .|  | .| |.. |.
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 341-448 4.5e-12 40.0 In-house 220-344 (349) alignment
Range on Protein: 341-448
Range on HMM: 220-344/349.0
MFHFHFKSWPDHGVPSDPSRVLNFLQ------DVNKKQETFP--DAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLD-CEI-------D-IYNTIRLV
.. . .| |.| ..  .|  .|. |.      | .  .  .   .  ...|||||| ||||... .|..|....    .   |       | |. ..  .
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnel

RQQRSGLVQTEAQYKFVYRAVQHYI
|.||  .||  ||. ..| |. .|.
rkqrismvqnlaqfiaiyealLkyf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 291-365 4.6e-12 40.4 In-house 116-190 (297) alignment
Range on Protein: 291-365
Range on HMM: 116-190/297.0
NKCCRYWPDANT-KKDTGVITVTHISEQSMAdYD---LREFSMSHKdfpEESRPMFHFHFKSWPDHGVPSDPSRVLNFL
.||  |||...  .. .| . | ..|. |   .|   | |. . ..   .||| . |  | ||||||||||   .  | 
dkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfq

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 382-444 4.8e-12 40.1 In-house 1-60 (69) alignment
Range on Protein: 382-444
Range on HMM: 1-60/69.0
IVHCSAGIGRTGTFIVIDIILNLIKQHGLdceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAV
.||||.| ||||||| | . .  ||   |   .||.| .. .|. |  .|  | .| |.. |.
vvhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdal

subfamily_eak_pd Subfamily eak 363-463 1.2e-11 38.6 In-house 221-320 (332) alignment
Range on Protein: 363-463
Range on HMM: 221-320/332.0
NFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGlDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNTL
. |. . ||    | . . |. .. |  |.|.|.|||....|| ..       . . |  |...|   | .. |. |.| .| .|. .  .|.   .. |
allsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkk.knlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyl

K
.
e

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 291-447 3e-11 37.5 In-house 134-289 (310) alignment
Range on Protein: 291-447
Range on HMM: 134-289/310.0
NKCCRYWPDANTKKDTGVITVTHISEQSmADYDLREFSMS--HKDFPEESRPMF-------HFHFKSWPDHGVPSDPSRVlnflqdVNKKQETFPDAGSI
 ||  |||     .  |.| || .|| |  .... .....    . | . .|           ..  ||| ||| .          | ..  .    |  
pkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht......vpqrllaqvrhgpc

IVHCSAGIGRTGTFIVIDIILNLIkQHGLDceIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHY
.||||||..|... . ... .. . ..||   .|. . .  ....|   .||| || .. |    .
vvhcsagkdrlyvvvalklkidkl.drglk..vdaeevktellksraiciqtelqyliidrvriif

subfamily_PTPDC1_pd Subfamily PTPDC1 327-446 5.4e-11 37.3 In-house 71-174 (182) alignment
Range on Protein: 327-446
Range on HMM: 71-174/182.0
FSMSHKDFPEESrpMFHFHFkSWPDHGVPSdpsrvLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIILnlikQHGLDCEidiyNTIRLVRQQ
|| . ... |.   .... | .|.|.||.|     |. . |. |  .   . | . ||| || ||||  |   ..     .. |. |    ..|.|||..
fsYdlealmeqg..iyvynf.gwkDygvas.....leriLdivkvvafalqegkvavhChaGlGrtGvliacylvy....akrltae....kaiklvrsk

RSGLVQTEAQYKFVYRAVQH
|.  .||  | ..|    ..
rpksiqtreqvelvkefalf

subfamily_ptpA1_pd Subfamily ptpA1 333-403 1.3e-10 35.6 In-house 180-254 (418) alignment
Range on Protein: 333-403
Range on HMM: 180-254/418.0
DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQE-TFPDA---GSIIVHCSAGIGRTGTFIVIDIILN
 |  |.| . ..... |||| .|     . ..|. . ..|.   | .     ||||||||.||||||    |...
tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_hpo-7_pd Subfamily hpo-7 289-446 6.2e-10 33.4 In-house 72-225 (263) alignment
Range on Protein: 289-446
Range on HMM: 72-225/263.0
AINKCCRYWPDANTKK-DTGVITVTHISEQSmaDYDLREFSMSH--KDfPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQetfpdagSIIVHC
...|| .|.|    .|     ..|.    ||  |  |.   .    ..   . . . |. .| |...  | ..  .|| |. . . .       |..|||
gvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekndpelareilnilkvarnsk.......slvvhc

SAGIGRTGTFIVIDIILN-LIK--QHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQH
|.||||.  | |....   .|.  .     |.|  . .. .|..|.. ..|  |  |    |  
stGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

subfamily_egg_pd Subfamily egg 285-449 1.2e-09 32.3 In-house 120-271 (307) alignment
Range on Protein: 285-449
Range on HMM: 120-271/307.0
SncvaiNKCCRYWPDANTKKDT---GVITVTHISEQSMADYDlreFSMSHKDF---PEESRPMFHFHFkSWPDHGVPSDPSRVLNFLQDVNKkqetfPda
|     ..|  ||| |...      | . .. .  .| ||     | ...       .| | . |.    .   .    | |||  |... |     |  
s.....erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk.....p..

gsIIVHCSAGIGRTGTFIVIDIIL-NLIKqhGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
  ..|..  |. ...|.. |.| | .|..  |      . ... ..|..|   |..  .| |||| |  .. 
..vvvqdilGvskaatlvaieiallsllr..Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 228-283 6.8e-09 30.2 In-house 13-66 (288) alignment
Range on Protein: 228-283
Range on HMM: 13-66/288.0
KSRENSKKAGFEEEFEALQLLDNKHllPRKIGDKAENKSKNRYKNILPYNIKVDQL
.  . ....||.||...|  |....    ..| .|.|..||||.|||||. |  .|
akksarnrtgfseeynsLaalektk..svtagrlavnakknRyrnilpyDekrvkl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 323-448 1.3e-08 28.9 In-house 158-279 (303) alignment
Range on Protein: 323-448
Range on HMM: 158-279/303.0
DLREFSMSHKDFpeesRP-MFHFHFKSWPDHGVPSD-PSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIVIDIIlnLIKQHGLDCEIDIYNTI
 |.  |.|  |.    .  .   |.|.||   .|||  ..... . ...     . |.   .    .| ||.||| ...     .  |  .  .|. . .
vlkvlsvsngdy....ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta..hlslhseqasldlvkcl

RLVRQQRSGLVQTEAQYKFVYRAVQHYI
  ||. |   ||  .|. .||  .  ..
envrngrlhavqnlsqfsvvytllaehv

subfamily_DSP23_pd Subfamily DSP23 335-442 2.2e-08 28.9 In-house 45-140 (148) alignment
Range on Protein: 335-442
Range on HMM: 45-140/148.0
PEESRPMFHFHFKSWPDHGvPSDPSRVLNFLQDVNKKQETfpdAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQTE
. |. |   ..    .|.  |  . .| .|.. |.. .|    . .. |||  | |||||..       |.|...|       ..|  ||..| | |.| 
hveatpnltlvrlriddyh.ppaleqvvefvrvveeaeek...neavsvhcllgrgrtgtmlac....ylvkerklaaa....eaiaevrrlrpgsvetv

AQYKFVYR
 | | |. 
eqeklvrd

subfamily_CG42327_pd Subfamily CG42327 286-370 3e-08 27.7 In-house 107-192 (319) alignment
Range on Protein: 286-370
Range on HMM: 107-192/319.0
NCVAINKCCRYWPDANTKKDT---GVITVTHISEQSMADYDLREFSMSHKDfPEESRPMFHFHFkSWPDHGVPSDPSRVLNFLQDVNK
    |..| .|.|  .| ..|   | | ||    ..   | .  . . . |  ||||.. |. .  |.. .||.... ..  | .|..
selGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvd.keesrelthywy.kwleaevPaeeaaliamllevrs

PTEN_1 338-440 6.1e-08 27.7 In-house 92-185 (196) alignment
Range on Protein: 338-440
Range on HMM: 92-185/196.0
SRPMFHFHFkSWPDHGVPSdPSRVLNFLQDVNKKQETFPDAGSIIVHCSAGIGRTGTFIvidiILNLIKQHGldceIDIYNTIRLVRQQR-SGLVQTEAQ
 . . . || ...|||.||  |... .. ..       |. . ..||| ||.||.|| .    .  |.. ..     .  ....|||..|  | ...  |
ksgveylhf.pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk....ltadeAlelvrekRppgapnspsq

YKFV
 ...
erll

subfamily_CDC14_pd Subfamily CDC14 351-441 9.7e-08 26.2 In-house 243-317 (328) alignment
Range on Protein: 351-441
Range on HMM: 243-317/328.0
DHGVPSDpSRVLNFLQDVNKKqetfpdAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQTEaQYKFVY
| ..||| . | .||. ..|        |.|.||| ||.|||||.|       |.|....  .    ..|  .|  | | | .  | ||..
DGstPsd.aivkkfleiaeka......eGaiavhCkaGLGrtGtLiac....ylmkhyrftaa....eaiawlricrPGsvigp.qqkfle

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 283-439 2.8e-07 24.3 In-house 140-293 (332) alignment
Range on Protein: 283-439
Range on HMM: 140-293/332.0
LDSNCVAINKCCRYWPDANTKKDTGVITVTHISEQSMADydLREFSMSHKDFPEESRpMFHFHFKSWPDHGV-PSD--PSRVLNFLQDVNKKQETFPDAG
|.   .  . | ..||. ..|||  ....    ..| .   .. | ..  .  .. .    .||  | |    |      |    || .   ..|    |
leecelkakicrkfwpekrskkdfpalsiqasddhseth..mktfnltvtekkqdhq.tvlmhfyewadasklpeymldmrasiklqyirsskktgvcig

SIIVHCSAGIGRTGTFIVIDIILNLIKQhglDCEIDIYNTIRLVRQQRSGLVQTEAQYKF
 |.. |..|. .   .  ||||.. | .   .  . . .|.  .. || | ..|   |  
pimlvcatgvekcaisatidiivsrite...ehrvgfketmsaikmqrfgcfrtvgpyst

subfamily_PTPRG_pd Subfamily PTPRG 224-277 3.2e-07 23.9 In-house 7-60 (563) alignment
Range on Protein: 224-277
Range on HMM: 7-60/563.0
EKETKSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYN
.|   |   . . ||.|||||||   ... |. .  .| ||| |||| ||..|.
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivayd

0048567 (Phosphotyrosine protein) phosphatases II 327-398 3.3e-07 24.8 In-house 16-97 (157) alignment
Range on Protein: 327-398
Range on HMM: 16-97/157.0
FSMSHKDFPEESRPMFHF-------HFKSWPDHGvPSDPSRVLNFLQDVNKKQETFP-DAGSIIVHCSAGI---GRTGTFIVI
. ..    |.    ...|       ..  . |.| | . ... .| . .||. . .    . |.|||.||    |||.|.|  
yfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc

subfamily_PTPRB_pd Subfamily PTPRB 221-281 6.1e-07 23.8 In-house 10-68 (293) alignment
Range on Protein: 221-281
Range on HMM: 10-68/293.0
EVLEKETKSRENSKKAGFEEEFEALQLLDNKHllPRKIGDKAENKSKNRYKNILPYNIKVD
| .|.  |. ..  ...| ||.| |.......    |. ..|.|..||||.|||||.    
ekfeehvkkmkadsdlrfseeyeelkavgkdq..avkaaelavnraknrytnilpydhsrv

subfamily_PTPRD_pd Subfamily PTPRD 208-278 7.5e-07 23.2 In-house 285-352 (564) alignment
Range on Protein: 208-278
Range on HMM: 285-352/564.0
ATRISASGIRNRVEVLEKETksrENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPYNI
 | .... ...... |.. .   |... .|.| ||. |.  ....|   . ..| .|| |||. |||... 
ntevesenlkqhlqkLaeve...edtemtgleleFqrLatakeieleefavatkpknkkknrfsnilales

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 220-277 9.8e-07 23.1 In-house 7-61 (319) alignment
Range on Protein: 220-277
Range on HMM: 7-61/319.0
VEVLEKETKSRENSKKAGFEEEFEALQLLDNKhllPRKIGDKAENKSKNRYKNILPYN
|. |....|  ... . ..|.||. |.  .|.     .  .| |||.||||.|||.|.
vqeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilayd

subfamily_PTEN_pd Subfamily PTEN 351-441 1.3e-06 23.5 In-house 89-173 (184) alignment
Range on Protein: 351-441
Range on HMM: 89-173/184.0
DHGVPSdPSRVLNFLQDVNKKQETfPDAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDcEIDIYNTIRLVRQqrSGlVQTEAQYKFVY
||  |.  . . ....|..|  |.  .   ..||| || ||||. ||  .. .|. ..  .  .......|   .  .| |.  .| ..|.
Dhnppp.lelleeivediekwlee.dkknvvvvHCkaGkGRtGvlivayllkslllekaee.alelfaeaRtknk..kg.vtiPsqrRYve

PTPc_motif_SM00404 359-427 1.3e-06 23.4 In-house 67-121 (140) alignment
Range on Protein: 359-427
Range on HMM: 67-121/140.0
SRVLNFLQDVnkkqetFPDAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQR
..||.|....        . |...||| ||. |..|.|.      |.....|. .    . ...|...|
dkvldfiena......ekkggkvlVHCqaGvSRSatliia....Ylmryrqlsla....eayefvkerR

subfamily_PTPN12_pd Subfamily PTPN12 231-279 1.5e-06 22.3 In-house 3-55 (290) alignment
Range on Protein: 231-279
Range on HMM: 3-55/290.0
ENSKKAGFEEEFEALQLLDNK----HLLPRKIGDKAENKSKNRYKNILPYNIK
|.. .. |..||..|. | .|    .  ... |.| ||. |||||.||||. .
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydks

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 373-449 1.5e-06 21.0 In-house 238-310 (346) alignment
Range on Protein: 373-449
Range on HMM: 238-310/346.0
ETFPDAGSIIVhCSAGIGRTGTFIVIdiiLNLIKQHGLDCEIDIYNTIRLVRQQRSGLVQTEAQYKFVYRAVQHYIE
. . .||  .|    | ||. .||     |  |.|     | .|.. .. ..||| | |.. |||  .|  |  || 
kqvqnagvcvv.slfgcgracsfiga...lyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia

subfamily_Ptp69D_pd Subfamily Ptp69D 221-277 1.8e-06 22.3 In-house 7-61 (307) alignment
Range on Protein: 221-277
Range on HMM: 7-61/307.0
EVLEKETKSRENSKKAGFEEEFEALQLLdnKHLLPRKIGDKAENKSKNRYKNILPYN
. ||.. |||..  . |...|.| |.    .  .  |...| ||. ||||..| ...
ddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafD

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 346-450 1.9e-06 21.6 In-house 234-340 (347) alignment
Range on Protein: 346-450
Range on HMM: 234-340/347.0
FKSWPDHGVPSDPSRVLNFLQDVNKKQETF-----PDAGSIIVHCSAGIGRTGTFIVIDIILNL-IKQHGLDCEidiyNTIRLVRQQRSGLVQTEAQYKF
  .|| .  | |  .|| ...   |.  |           ..| |  |. |. | ..  ||..  .. .  ||.    . .. .|.||.|.      | .
cttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcd....dlfkkmrdqragvftmsifyty

VYRAVQHYIET
  ||   |.  
airaalfylkl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 221-278 2.6e-06 21.9 In-house 12-70 (298) alignment
Range on Protein: 221-278
Range on HMM: 12-70/298.0
EVLEKETKSRENSKKAGFEEEFEALQLLDN-KHLLPRKIGDKAENKSKNRYKNILPYNI
. |.| .. ... | .|...||. |.   .  .    ... | |||.|||| .|.... 
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialds

subfamily_PTPRA_pd Subfamily PTPRA 220-278 4.4e-06 20.8 In-house 16-72 (330) alignment
Range on Protein: 220-278
Range on HMM: 16-72/330.0
VEVLEKETKSRENSKKAGFEEEFEALQLLDNKHLLprKIGDKAENKSKNRYKNILPYNI
|| ||.| . |       | |||.||   . .  |  .. .| ||| |||. |||||. 
vekleeeirirsaddnklfreefnalPagpiqatl..elaskeenkeknrvvnilPydf

DSPc Dual specificity phosphatase, catalytic domain 360-432 5.4e-06 21.3 Pfam-A 61-119 (133) alignment
Range on Protein: 360-432
Range on HMM: 61-119/133.0
RVLNFLQDVnkkqetFPDAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQ
.. .|....        . ....||| ||| |..|.|.      |.|...|. .    . ...|...|| ...
eavefieka......eqkgkkvlVHCqaGisRSatliia....Ylmktknlsln....eAyefvkerrskisp

DSPc Dual specificity phosphatase, catalytic domain 360-432 5.4e-06 21.3 In-house 61-119 (133) alignment
Range on Protein: 360-432
Range on HMM: 61-119/133.0
RVLNFLQDVnkkqetFPDAGSIIVHCSAGIGRTGTFIVIdiilNLIKQHGLDCEidiyNTIRLVRQQRSGLVQ
.. .|....        . ....||| ||| |..|.|.      |.|...|. .    . ...|...|| ...
eavefieka......eqkgkkvlVHCqaGisRSatliia....Ylmktknlsln....eAyefvkerrskisp

subfamily_PTPN13_pd Subfamily PTPN13 238-286 5.7e-06 20.8 In-house 13-59 (273) alignment
Range on Protein: 238-286
Range on HMM: 13-59/273.0
FEEEFEALQLLdnKHLLPRKIGDKAENKSKNRYKNILPYNIKVDQLDSN
 .|||. |. |  | |.  ..| |.|||.||||.|.|||.    .|...
Paeefkelrel..kpldtcevgkkkenkdknryrnvlPydetrvklgde

subfamily_CDKN3_pd Subfamily CDKN3 345-452 9.1e-06 19.4 In-house 103-200 (202) alignment
Range on Protein: 345-452
Range on HMM: 103-200/202.0
HFKSWPDHGVPsDPSRVLNFLQDVNKKQETfpdAGSIIVHCSAGIGRTGtfIVIDIILNLikqhgLDCEIDIYNTIRLVRQQR-SGLVQTEAQYKFVYRA
|    .| .|| |..  |..|....   ..       .|||  |.||.   .||  .| .     ||  |.  ..|  .|. . |. .||  || ..   
hhypiadglvp.diasclkileelrinlka...yrktlvhcygglgrss..lviacllly.....lddtiepkdaidklrdlkgsraiqtvkqynylsef

VQHYIETLS
 ..  | ||
rdkleeyls