Gene PTPN9 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN9
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP066_AA protein Get Run
SpurP066_AA_287-578 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN9_pd Subfamily PTPN9 288-583 2e-160 527.7 In-house 1-296 (297) alignment 
Range on Protein: 288-583
Range on HMM: 1-296/297.0
MDIEALVSYVLNMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSD
..||.||.|| .....|..||||.||.||..|||.|||.|.|..||||.||||||..||.|. ...|..|||.|||..||||||.|||||||.|.||.||
keieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFRE
||.|.||.....||||||.||||||||||||||||..| |.|..||.|.|.|...||...||...|..|.|||..|||||.||||.|.|.|| ..|...|
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

EVRQYQSTSVKEMGDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKL
.||..|...|||.||||.||| ||||||||||||||||||.||||.|.|||.|.|.||..||.|.|.|||.|||||.||||||.|..|||.....|
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelkal
subfamily_PTPRD_pd Subfamily PTPRD 289-579 3.9e-106 350.9 In-house 6-283 (564) alignment 
Range on Protein: 289-579
Range on HMM: 6-283/564.0
DIEALVSYVLNMR---QSGIYKEYAAIRAEpPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTF
 ...| ..| ...   .  . .||  |. . .  |. |...  | .|||||... |||||| |  ..||. ||| ||...|||....|.||||| |..|.
pvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

SDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEeGtSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEF
.||| |.|| ...|||| |...|.|. || .||| . | . .||.. |   | |.  ||.|. .........||| ...|.|||||| | | || ..|..
edFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

REEVRQYQStsvkemgdewtghPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
...||....             |.  |||||||||.||||||...|. | |... .|.|. ..|...|.|| . .||..|| |.. |..|. . 
irkvralne.............pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0050432 (Phosphotyrosine protein) phosphatases II 300-579 2.3e-102 337.7 In-house 39-301 (308) alignment 
Range on Protein: 300-579
Range on HMM: 39-301/308.0
MRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpilngDPYSDYLNANYMDGY--KQKNAFIATQGALPKTFSDFWLMIWESQC
.  .....|. .... .| ........  |..|||| |.|.||||||.|     |. ||| ||.|.|||  |....|||||| ||.|. ||| |.|| ..
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

RTIVMTTRTVERGRLKCGQYWPLEEG-TSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQsts
|.||| |..||.|| || ||||||.| .| ||||..| .|..|.. |||...|.. |. ..|||..|||..|.|||.|.| |. ..|.| |.||...   
rvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...

vkemGDewtghpggPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
    ..        .|||||||||.||||||..||. | .||   ..||...|. .| ||....|||.||.|.| ||.||...
....pg........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 290-577 6.5e-102 336.1 In-house 10-286 (288) alignment 
Range on Protein: 290-577
Range on HMM: 10-286/288.0
IEALVSYVLNMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFW
.. || ..|   ..|...|. ....  | .|..|...  |..|||| |.|.||||||.|  |.|.. ||| ||.|.|||..|..|||||| ||.|..|||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

LMIWESQCRTIVMTTRTVERGRLKCGQYWPLeeGTSGEYGKISVANLEIETRRDYTITVLTVHNS----TTNESRRITHFQFTSWPDFGTPRSALAMLEF
 |.|| ..|.||| |..||.|| || |||||  |.| .||.|.| .|..|.  |||...|.| |      ..|||..|||..|.|||.|.| |. ..|.|
rmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldf

REEVRQYQStsvkemgdewtghPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
 ..||....             .||.|.|||||||.||||||..||. | .||   ..||...|. .| || ...|||.||.|.| ||.||.
lrlvrkala.............sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 304-579 1.3e-98 325.1 In-house 1-276 (284) alignment 
Range on Protein: 304-579
Range on HMM: 1-276/284.0
GIYKEYAAIRAEPPAG--TFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGD-PYSDYLNANYMDGY-----KQKNAFIATQGALPKTFSDFWLMIWES
|...|. ...   .    .......  |..|||| |.|.||||||.|  |.|| . ||| ||.|.|||     ..|..|||||| ||.|. ||| |.|| 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

QCRTIVMTTRTVERGRLKCGQYWPLEeGTSGEYGKISVANLEIETRRDYTITVLTVHNST-TNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQS
..|.||| |..||.|| || |||||| |.. .||...| .|..|.. |||...|.. |   |.|||..|||..|||||.|.| |.  .||| ..||....
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

TsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVA---TIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
            .|||.|||||||||.||||||..||. | .||      ..||...|. .| || ...||..||.|.| ||.||...
n...........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0040438 (Phosphotyrosine protein) phosphatases II 288-586 1.6e-97 321.8 In-house 3-285 (317) alignment 
Range on Protein: 288-586
Range on HMM: 3-285/317.0
MDIEALVSYVLNMRQSGIYKEYAAIRAEPPAgTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSD
.|.. .. ..|..   ....|.  ..  ..  |.  ...  | .|||| |.|.|||||| |  |.||. ||| ||.|.||...|..|||||| ||.|. |
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLeeGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFRE
|| |.|| ....||| |...|.|| || |||||  |.. .||...| .|..|.  ..|...|.| .. ..|||..|||..|.|||.|.| |   .|.| |
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

EVRQYQstsvkemgdewTghPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKLPSS
.||...              ..| |..||||||.||||||..... | .||   ..|| ..|. .|.||....|||.||.|.| || || .| ..|.. 
avreal...........e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa
0036941 (Phosphotyrosine protein) phosphatases II 300-579 1.6e-97 321.6 In-house 10-279 (297) alignment 
Range on Protein: 300-579
Range on HMM: 10-279/297.0
MRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpilnGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRT
.  ....||.  .    . |......   |..|||| |.|.|||.|| |    .|. ||| ||.|.|||..|..|||||| ||.|. ||| |.|| ....
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIET--RRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSv
||| |. ||.|| || |||||||| | .||...| .|..|.    |||...|.| .  ..|||..|||..|.|||.|.| |.  .|.| |.||.... . 
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.

kemgdewtghPGGPPIVVHCSAGIGRTGTFCTLDISLARLE---DVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
          |.|.|..||||||.||.|||...|. | .||      ..|....|. .| ||. ..||..||.|.| || |. ..
..........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0047943 (Phosphotyrosine protein) phosphatases II 303-577 4.3e-97 320.1 In-house 12-272 (273) alignment 
Range on Protein: 303-577
Range on HMM: 12-272/273.0
SGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpilnGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVM
.....|. ...  .| .|......  | .|||| |.|.||||||.|    ||. ||| ||.|.|||..|..|||||| ||.|. ||| |.|| ..|.|||
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

TTRTVERGRLKCGQYWPLEEGT-SGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKEmg
 |..||.|| || ||||||.|. | .|||..| .|..||. |||...|.. |. |.||| .|||..|.|||.|.| |   .||| |.||.........  
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn..

dewtghpggPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
         .|.|||||||.||||||..||. | .||   ..||...|.|.| || ...|||.||.|.| ||.||.
.........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 293-579 1.7e-92 305.3 In-house 22-291 (297) alignment 
Range on Protein: 293-579
Range on HMM: 22-291/297.0
LVSYVLNMRQSGIYKEYAAIRAEPPAgtFYASKHRLNVHKNRYADVLCYDHSRVFLPILNG-DPYSDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWL
|. .   .  .....|.  .   .|   .. ...  |..|||| |.|.|||||| |  ..| |. ||| ||.|.|||.. ...|||||| ||.|. ||| 
llllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MIWESQCRTIVMTTRTVERGRlKCGQYWPLEEGtsgEYGKISVANLEIETRRDYTITVLTVHNstTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVR
|.|| ....||| |..||.|| || |||| |.|   .||...| .|..|.. .||...|.| |  ..||| .||||.|.|||.|.| |.  .||| |.||
mvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

QYQSTSvkemgdewtghPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
......           |.| |..||||||.||||||..... | .||   ..|| ..|. .| || ...|||.||.|.| ||.|. .|
ealael...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0045450 (Phosphotyrosine protein) phosphatases II 302-576 3.7e-92 304.6 In-house 26-303 (307) alignment 
Range on Protein: 302-576
Range on HMM: 26-303/307.0
QSGIYKEYAAIRAEPP--AGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGD-PYSDYLNANYM--------DGYKQKNAFIATQGALPKTFSDFWL
 .|..||.  .. . .   |.......  | .|||| |.|.|||.|| |  |.|. . ||| ||.|.        |||..|..|||||| ||.|. ||| 
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

MIWESQCRTIVMTTRTVERGRLKCGQYWPLEeGTSGEYGKISVANLEIETRRDYTITVLTVHNS-TTNESRRITHFQFTSWPDFGTPRSALAMLEFREEV
|.|| ....||| |..||.|| || ||||.| |.. .||.. | .|..|.  .||...|.|...  |.|||..|||..|.|||.|.| |   .|.| |||
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RQYQSTsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVAT---IDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
|.....           .|.| |..||||||.||||||..... | .||.  |   .|. ..|.|.|.||  ..|.|.||.|.| || |.
rkalee...........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 287-576 4.9e-92 303.6 In-house 4-276 (278) alignment 
Range on Protein: 287-576
Range on HMM: 4-276/278.0
GMDIEALVSYVLNMRQSGIYKEYAAIRAEPPaGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFS
 .|.. .. ..|   ......|.  ..  .. .|.. ...  |..|||| |.|.|||||| |  |.||. ||| ||.|.|||.....|||||| ||.|. 
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPleeGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFR
||| |.|| ...|||| |. ||.|| || ||||   |.| .||...| .|..|.  |||...|.|.|  ..||| .||.....|||.|.| |   .|.| 
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

EEVRQYQstsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
..||...             .. . |..||||||.||||||..|.. | .||.  ..|....|. .| ||. ..|||.||.|.| || ||
kavreal.............edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 289-581 4.2e-91 300.3 In-house 3-284 (318) alignment 
Range on Protein: 289-581
Range on HMM: 3-284/318.0
DIEALVSYVLNMRQSG---IYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTF
..|.| | | ..|.||   . .|| ..  ..   | . | .  | .|||||..| |||.|| |  |.|.. |||.||||.|||..|.|.||.|. ||.|.
svedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpeti

SDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEgtSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEF
.||| |.|| ....||| |...|||. |. .||| ..  | .|||. |   |  .  ||..  ..|... ..||| .  ...||||| |.| |.  .|..
eDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

REEVRQYQStsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSD
  .|...|             ..|  |||||||||.||||.|...|| | |... |..|| .||. .| ||   .|| |||||.| .|.|. .  |
vrqvskaqq............ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
DSPc_SM00195 306-577 1.3e-88 292.1 In-house 3-262 (263) alignment 
Range on Protein: 306-577
Range on HMM: 3-262/263.0
YKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTR
 .|.  .... .  ..  ...  |..|||| ..|.|||.|| |.  .... |||.||||..|...|...||||| ||.|..||| |.|| ....|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

TVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRR-DYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvkemgdew
 .|.|. || .||| |.|.. ..||||| . | |... ......|.. . ...|.|..|..|...||| |.| |.  .||. ..|.. .|||        
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........

tghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
      .|||||||||.||||||.|.|| | .||.  ..|....|. .| ||. ..|| .|| |.| |..||.
.....sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 306-577 1.3e-88 292.1 In-house 3-262 (263) alignment 
Range on Protein: 306-577
Range on HMM: 3-262/263.0
YKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTR
 .|.  .... .  ..  ...  |..|||| ..|.|||.|| |.  .... |||.||||..|...|...||||| ||.|..||| |.|| ....|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

TVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRR-DYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvkemgdew
 .|.|. || .||| |.|.. ..||||| . | |... ......|.. . ...|.|..|..|...||| |.| |.  .||. ..|.. .|||        
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........

tghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
      .|||||||||.||||||.|.|| | .||.  ..|....|. .| ||. ..|| .|| |.| |..||.
.....sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 320-576 5.9e-87 286.6 In-house 2-245 (249) alignment 
Range on Protein: 320-576
Range on HMM: 2-245/249.0
TFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWP
... ...  |..|||| |.|.|||||| | ||.| . ||| ||.|.|||..|..|||||| ||.|..||| |.|| ....||| |..||.|| || ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

LeeGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvkemgdewtghPGGPPIVVHCSA
|  |.| |||...| .|..|.  |||...|...|. ..|||...|.|.|.|||.|.| |   .|.| |.||.....            | | |..|||||
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...........pkggpvlVHCsa

GIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
|.||||||..... | .||   ..|. ..|.|.| || ...|.|.||.|.| || |.
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 305-579 2.9e-85 281.3 In-house 9-274 (278) alignment 
Range on Protein: 305-579
Range on HMM: 9-274/278.0
IYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFlpilngdpysDYLNANYMDGYkqKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTT
.. |.  ... .. .... .  . |..|||| |.|.||||||.          ||.||.|.|||  ...|||||| ||.|..||| |.|| ....||| |
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

RTVERGRLKCGQYWPlEeGTSGEYGKISVANLEIETRRDYTITVLTVHNS----TTNESRRITHFQFTSWPDFGTPRSA--LAMLEFREEVRQYQSTSVK
. ||.|| || |||| | | | .||...| .|..|.  |||...|.|.|     ...||| .||.....|||.|.| .     .||. |..|..... ..
elvelgrekcaqywp.e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

EMGDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLeDvATIDVCNTVRLMRAQRAY-SIQTPDQYEFCYFALVEYAQR
 .. ... ...| |..||||||.|||||.. ... | .| .  ..|. ..|. .| || . ..|...||.|.| .|.|. .|
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 289-581 5.1e-85 280.3 In-house 6-287 (319) alignment 
Range on Protein: 289-581
Range on HMM: 6-287/319.0
DIEALVSYVLNMRQS---GIYKEYAAIRAEPPAgTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTF
... | ... .....   .. ||.  ..   .  ||. ...  | .|||| ..| ||..|| |. |.| . |||.||...|||.....|||||. | .|.
evqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

SDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEgtSGEYGKISVANLEIETRRDYTITVLTVHNSTTN-ESRRITHFQFTSWPDFGTPRSALAMLE
.||| |.|| .. ..|| |. ||....|. .||| |.    |||.. |  .| |   || |  |.... ... |.|...|||.|.||| . |..|...|.
edfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslld

FREEVRQYQSTSVKemGdewtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSD
. ...|. .. . .  |          |||||||||.||||||..||. | |..  ...|| .||. .|.||   .|.|.||.|.| ||.|...  |
llkrirksrektqs..g..........PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0042113 (Phosphotyrosine protein) phosphatases II 326-576 1.7e-84 278.3 In-house 6-242 (245) alignment 
Range on Protein: 326-576
Range on HMM: 6-242/245.0
HRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLeeGTS
.  |..|||| |.|.|||.|| |.  .||. ||| ||.|.|||.... |||||| ||.|. ||| |.|| ...|||| |...|.|| || |||||  |.|
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

GEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTsvkemgdewtghPGGPPIVVHCSAGIGRTG
 .||...| .|..|.  |||...|.|.|  ..||| ..|.....|||.|.| .   .|.| |.||....             ... |..||||||.||||
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae............dsngpvlVHCsaGvgRtG

TFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
||..... | .||   .... ..|. .| ||  ..|||.||.|.| || |.
tfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 329-574 4.8e-83 273.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 329-574
Range on HMM: 1-234/235.0
NVHKNRYADVLCYDHSRVFLpilNGDPY-SDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGE
| .|||| |.|.||..|| |   .|..  ||| ||||..|||.|..|||||| |..|..||| |.|. ....||| |. .|.|| || |||| ||..| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKISVANL-EIE-TRRDYTITVLTVHNSTTN-ESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQstsvkemgdewtgHPGGPPIVVHCSAGIGRT
||.|.| .  ...    .||...|........ |.|.......|.||| |.|.|. ..|.. ..|....             ..   |.|||||||.|||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRt

GTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALV
|||..||| | .||.  ..||...|. .|.||. ..|. .||.|.| |..
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 329-574 4.8e-83 273.5 In-house 1-234 (235) alignment 
Range on Protein: 329-574
Range on HMM: 1-234/235.0
NVHKNRYADVLCYDHSRVFLpilNGDPY-SDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGE
| .|||| |.|.||..|| |   .|..  ||| ||||..|||.|..|||||| |..|..||| |.|. ....||| |. .|.|| || |||| ||..| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKISVANL-EIE-TRRDYTITVLTVHNSTTN-ESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQstsvkemgdewtgHPGGPPIVVHCSAGIGRT
||.|.| .  ...    .||...|........ |.|.......|.||| |.|.|. ..|.. ..|....             ..   |.|||||||.|||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRt

GTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALV
|||..||| | .||.  ..||...|. .|.||. ..|. .||.|.| |..
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRB_pd Subfamily PTPRB 301-580 1.2e-81 269.0 In-house 23-288 (293) alignment 
Range on Protein: 301-580
Range on HMM: 23-288/293.0
RQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTI
 . .. .||  ..|     .  |...  |  |||| ..| |||||| |  |.... |||.||||..||.... |||||| ||.|. ||| |.||.....|
sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssii

VMTTRTVERGRLKCGQYWPLEEGTSgEYGKISVANLEIETRRDYTITVLTVHNstTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKEM
|| |..||.|. || .||| .| .   ||.|.|  .. |. .|..|  |....  ..|.|......||||||.| | .. ..|.| ..||...... .. 
vmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

gdewtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
           |||||||||.|||||| .||  | ..|.  ..|.. .|  .| .|.. .|| .|| | . ..... ...
...........PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 301-579 1.4e-81 268.7 In-house 13-278 (281) alignment 
Range on Protein: 301-579
Range on HMM: 13-278/281.0
RQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTI
 ..|  .||....|     |  |||.  ||.|||| ..  ||..|| .   . .  .||.|||...|||.....||||| .|... .|| |.|| . ..|
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMTTRTVERGRLKCGQYWPlEEGTSGEYGKISVANLEIETRRDYTITVLTVhNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKem
|| || .| |.||| .||| .. .. .||.. | ... |... |   .... . ...|.|.......|.||| | | .. ..||||.||....... |  
vmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..

gdewtghpggPPIVVHCSAGIGRTGTFCTLDISLARLED-VATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
           |.|.|||||.|||||. .||  . ..|.  ...||...|. .| .| . .||  |||| | |.... ..
..........aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPRA_pd Subfamily PTPRA 306-580 1.8e-80 265.3 In-house 35-298 (330) alignment 
Range on Protein: 306-580
Range on HMM: 35-298/330.0
YKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTR
 .|. |. | |  .|. ....  | .|||. ..| ||.|||.|. ..| ..|||.|| ..||||.|. |||.|| . .|  ||| |||| .  |||| | 
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte

TVERGRLKCGQYWPlEEGTSgEYGKISVANLEIETRRDYTITVLTVH----NSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvkemg
  || . || |||| .||.   ||.| |.  . .   |||.  . |.    ..  ..|| .. | ||||||.| |  .  ||.. ..|.. .  |     
lkerkeekcaqywP.deGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs.....

dewtghpGGpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
       .| |||||||||.||||||..||  |.|..    .|| ..|. .|.||.  .||  ||||.| .| ||    
.......ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 306-578 8.9e-80 263.1 In-house 33-291 (298) alignment 
Range on Protein: 306-578
Range on HMM: 33-291/298.0
YKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTR
...  ..  | .. .  ..... | .||||||.. .|.||| |   ..|  |||.|| ....||..|||||||. |..|..||| |..| .  |||| | 
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltn

TVERGRLKCGQYWPLEegTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvkemGDEwt
..| ...|. .||| |   . .||.|.|  |. |.  |.... |.|........|.. ...|||||| |.|. | ..|.....||..|. .    |..  
leeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa....gnk..

ghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
      |..|.||||.||.|||. .|  | |..   ..|| ..|. .|..|. ..|| .|| |.| |  |. .
......pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0037934 (Phosphotyrosine protein) phosphatases II 322-576 7.7e-77 253.4 In-house 3-241 (243) alignment 
Range on Protein: 322-576
Range on HMM: 3-241/243.0
YASKHRLNVHKNRYADVLCYDHSRVFLpilngDPySDYLNANYMDGYKQknaFIATQGALPKTFSD----FWLMIWESQCRTIVMTTRTVERGRLKCGQY
. ...  |..|||| |.|.||||||.|     .. |||.|||.......   .||||| ||.|. |    || |.|| ....||| |..||.||.|| ||
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPleeG-TsgEYGKISVANLEIETRRDYTITVLTVHNST-TNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVkemgdEWTGHPGGPPIVV
||   | .  .||...| .|..|.  |||...|.. |   ....| ..|.....|||.|.| |   .|.| .|||....  .      ..  ..| |..|
wp...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell.....sllaldsggpvlV

HCSAGIGRTGTFCTLDISLARLedvaTIDVCNTVRLMRAQRAY-SIQTPDQYEFCYFALVEY
|||||.|||||...... | .|    ..|. ..|.|.|.|| . ..|||.||.|.| || |.
HCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN6_pd Subfamily PTPN6 299-583 4.8e-76 250.7 In-house 22-303 (306) alignment 
Range on Protein: 299-583
Range on HMM: 22-303/306.0
NMRQSGIYKEYAAIRAEPPAGTFY--ASKHRLNVHKNRYADVLCYDHSRVFLPiLNGDPYSDYLNANYMDG--YKQKNAFIATQGALPKTFSDFWLMIWE
.. ..|. .|. ... |    ..    ...  | .||||  .| .||.|| |   .. | |||.||||...   ......|||||.|..| |||| |.|.
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

SQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGeYGKISVANLEIETRRDYTITVLTV-HNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQ
 ..| |||||. ||||. || .||| || ..  |||||| |.. .. .||..  |.| .... .|.|.. ...|.|||| |.|..  |.|.| |.|.. |
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

STSVKEmgdewtgHPGgpPIVVHCSAGIGRTGTFCTLDISLARLEDV---ATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKL
... ..       ..|  ||||||||||||||||  .|| |  .|     | ||. ..|...|.||   .|| .|| | | |. .| ... ||
eeleea.......eag..pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl
subfamily_PTPRK_pd Subfamily PTPRK 303-577 6e-76 250.3 In-house 22-277 (314) alignment 
Range on Protein: 303-577
Range on HMM: 22-277/314.0
SGIYKEYAAIRAEppagtFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVM
 |. .|| ..        . |.|.  | .|||. |.| ||.|||||  ..||| |||.||...|.||. .|||.||| |..|  ||| .... .| .|||
ygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivm

TTRTVERGRLKCGQYWPlEEGTSgeYGKISVANLEIETRRDYTITVLTVHN--STTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTsvkem
 |  || ||.|| .||| |...   ||.| |  .| |.  .. . ...|..   . .| | . .|||..|||...| || ..|..  .| . |       
ltelvevgrvkClkyWP.edtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.....

gdewtghpGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
        .  .|||||||| ||||||...|| |  .|   ..|| |.|. .|...   ..| .|| |.| ...| .
........eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileac
subfamily_PTPRG_pd Subfamily PTPRG 301-578 6.2e-75 247.5 In-house 17-288 (563) alignment 
Range on Protein: 301-578
Range on HMM: 17-288/563.0
RQSGIYKEYAAIRAEPPAG--TFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYS-DYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQC
 . |. .|. |.  |  .   .  .|... | .|||| ... ||.||| |  | |   . ||.||||.|||....|||||||.|..|| ||| |||| . 
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

RTIVMTTRTVERGRLKCGQYWPLeeGTSGEYGKISVANLEIETRRDYTITVLTVHN------STTNESRRITHFQFTSWPDFGTPRSALAMLEFreeVRQ
 .||| |  ||||| || .|||    .| .||...|   | |.   ||.  |...|      . ... ........|.||| |.| ..|  | |   |..
aiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif...vkk

YqstsvkemgdEWT-----GhpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
           . .     |     |||||||||.|||||.. ||  | ....  ...| .... .|||| . .|| .|| | . ||.|  .
s..........saankaeaG.....PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 294-581 6.1e-74 243.9 In-house 10-287 (305) alignment 
Range on Protein: 294-581
Range on HMM: 10-287/305.0
VSYVLN---MRQSGIYKEYAAIRAEppAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWL
 .|. .   . ..|. ..| ..  |    ..   |.  |..|||....  .|..|. |   . .. |||.||.|.||||.|...|..|| |..| .||| 
aayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWr

MIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHN-STTNESRRITHFQFTSWPDFGTPRSALAMLEFREEV
.|.| . .|||| |..|| |. || |||| ... . |.|..||   . .|  ||..  |.. . .. .||| ....|.|.||| | |..| ..|.. ..|
liveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

RQYQSTSvkemgdewtghpGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSD
.. |. .             | |..||||||.||||.|...|| | ||.   ..|| . .. .| .| . .|| ||| |.. || |. .  |
qkdqkkd............kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 325-579 2.3e-73 241.5 In-house 5-244 (250) alignment 
Range on Protein: 325-579
Range on HMM: 5-244/250.0
KHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLkCGQYWPLEEgt
|.  | .||||||.. .|.||| |   .||  |||.|| ...||....||||||| |..|. ||| |..| .  |||| |  .| ..  . |||| |.  
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..

SGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvkemgdewtghpGGPPIVVHCSAGIGRT
. .||.. |  |. |.  |||...| . . . ...| . ...|..||| | |. | |.||....|.. |  .            |  |..|.||||.||.
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa............gnaPvivqCsaGvgrs

GTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
|.|...|  | ||.   ..|| . .. .|..|  .... .|| |.| .. .. . 
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 299-577 5.6e-73 240.5 In-house 17-279 (288) alignment 
Range on Protein: 299-577
Range on HMM: 17-279/288.0
NMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCR
 . ..|. .|| .. |     .  |...  | .|||| ..| ||. || |  |.  . .||.||.|.||.|.|...||||| |..|  ||| ...| .  
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIVMTTRTVERGRLKCGQYWPLEeGTSGEYGKISVANLEIETRRDYTITVLTVHnsTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvk
|||| |  ||.|. ||..||| . ..  .||.. |  .| ..  |..   | ..   ... ..||..|...||| | |.|.  .||... | . ..    
tivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..

emgdewtghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
             ||.||||||.|||||| .||  . ..|   .|||..||  .| |||  .||  ||||.| .|.. .
...........tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 290-576 1.2e-72 239.5 In-house 8-278 (315) alignment 
Range on Protein: 290-576
Range on HMM: 8-278/315.0
IEALVSYVLNMRQ---SGIYKEYAAIRAEPpAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFS
.. |..|| . .     |. ..| .|        .  .|.  |..|||| ... ||.|||.||.|. || |||.|||..|||..|. .||.|| .. .  
ldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvk

DFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEegtSGEYGKISVANLEIETRRDYTITVLtvHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFR
||| ...| .. .||| | .||. . |. .||| .      ||||.|.  . |   .||.  |       .. | .  ...||||| | |......... 
dfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnli

EEVRQYQSTSVkemgdewtghpggPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
  |.|.. .||              .||||||||.||||||.|||  | ..|    ||| | .. .|..|   .|. .||.| | ||.| 
rtvkqhhtnsv.............gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN12_pd Subfamily PTPN12 324-580 7.5e-72 236.6 In-house 35-280 (290) alignment 
Range on Protein: 324-580
Range on HMM: 35-280/290.0
SKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEG
...  ||.|||| |.| ||.||| |   .... |||.|||.. | ..| ..||.|| |||| .||| |||| . . .||  | || |. || .||| | .
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

TSGEYGKISVANLEIETRR-DYTITVLTVHNSttNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQStsvkemgdewtghPGGPPIVVHCSAGIG
.. |.|...| . | ..   |..|  |.|...  .|||... |..|.||| |.|.||  .||. |.||..|.                 |.|||||||.|
eelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.............sedaPlvvhCsaGvG

RTGTFCTLDISLARLEDVAT---IDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
|||| ...|.    |..  .   .|| . |. .| |||  .|| .|||. | |..|. |..
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Ptp69D_pd Subfamily Ptp69D 303-581 1.7e-71 235.9 In-house 22-290 (307) alignment 
Range on Protein: 303-581
Range on HMM: 22-290/307.0
SGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVM
 |. |||  . |.    .  .|..  |  |||| |.  .|. || |. .||. .|||.||... |||.|. ||| |. .  |  ||| ||.| .  .|||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

TTRTVERGRLKCGQYWPLEegTSGEYGKISVANLEIETRRDYTITVLTVHNST-----TNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSv
 .   |  | || .||| |  .  .||.| |   . |.  ||.|  | | .        ..||... ...|.|.|.  |..| ..|.. |.||. .... 
lsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.

kemgdewtghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSD
              ||||||||| ||.|.| .||. | .|.   ..|...||. .| ||   .|  .||.|.| ||..| . .|
............rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 330-580 4.4e-71 234.2 In-house 29-271 (274) alignment 
Range on Protein: 330-580
Range on HMM: 29-271/274.0
VHKNRYADVLCYDHSRVFLPI-LNGDPYSDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGT--S
 .|||| ..|  ..||| |    . |. |.|.||||. ||.. ..|..|||| ||.| .|||.||.. ... |||.|.  |. . || .|.| .|..  |
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

GEYGKISVANLEIETRRDYTITVLTVHNSTTneSRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKEMGDEwtghpggppiVVHCSAGIGRTG
..||.... . .| .| ||... |......   .|...|. .|.|||  .|..| ..|.. .||.. .... ....            ||||||||||||
erygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv..........vvhCsaGiGrtG

TFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
 | . .|.. .|..  ..|| ..|  .| .|   .|| .|||. . ||..|..| 
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_PTPN3_pd Subfamily PTPN3 306-573 1.2e-70 232.7 In-house 18-271 (280) alignment 
Range on Protein: 306-573
Range on HMM: 18-271/280.0
YKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpilNGDPYsDYLNANYM----DGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIV
 ...  .    |  .  |..   |..|||| |.| ||. || |   .  .  ||.||||.    .. .. | .||||| |.|| .||| |.|| ....||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvkl...keset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MTTRTVERGRLKCGQYWPLeEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQstsvkemg
| | .||||| || ||||  .. . |||..||   . .... | .  |......|.|.|.|...|...||| | | ..  .||| |.||...        
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr........

dewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFAL
     .    |.|||||||||||| . .|...|| .|    . . . || || |||  .||..||.|   |.
.....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 295-590 7.9e-69 226.9 In-house 10-290 (315) alignment 
Range on Protein: 295-590
Range on HMM: 10-290/315.0
SYVLNMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWE
..| . |.. .. |      .|..    ..... | .|||| ..| .|..|| | ... .| |||.|| |. .... .|.||.|| |. . .||| |...
afvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlq

SQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSttNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYqs
..  |||| |   |  ..|| |||| ... | |.|.|.|. |..|.  | ..  |.. .|  .|||..| |||| ||| |... . ..|..  ||.    
ekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkad..

TSVKEMgdewtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKLPSSIDFS
   ||            ...||||||.|||| ....|  .|....  ..|| |.|. .||.| | .|| ..| | | |. |. .  . |   | |.
ngkkef...........sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihft
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 320-599 1.1e-68 226.9 In-house 52-313 (319) alignment 
Range on Protein: 320-599
Range on HMM: 52-313/319.0
TFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTrtvergRLKCGQYWP
.   .    |  |||. ..| .|...| |  |.|  .|||.|| ...||..|. .||.|| |. |  ||| ||||..| |||. |      . || ||||
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

LEEGTSGEYGKISVANLEiETRRdYTITVLTVHN-STTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQStsvKEMGDEwtghpggpPIVVHCS
|.     | .|..|  .| ||   |..  . . . .  .. |.|| | |  ||| | | ..  .. . . ||  .|   || . .        .||||||
lkivikeerfkvkvdsve.etae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts...kenhra........nivvhcs

AGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKLPSSIDFSGYEDSESDS
||.||||.. .||. | |...   .|| |.|| .| ||   .|   || |.| ||.|    .    .  ||  | .  |. 
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 324-598 7.7e-68 224.0 In-house 20-276 (284) alignment 
Range on Protein: 324-598
Range on HMM: 20-276/284.0
SKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTrtvergRLKCGQYWPLEEG
.    |  |||. ..| .|...| |  | |  .|||.|| .. ||..|. .||||| |. |  ||| ||||..| |||. |      . || |||||.  
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

TSGEYGKISVANLEiETrRDYTITVLTVHN-STTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQStsvKEMGDEwtghpggpPIVVHCSAGIG
   | .|..|  .| |.  .|..  . . . .  .. |.|. | |  ||| | | ..  .. . . ||  .|   || . .        .||||||||.|
ikeerfkvkvdsve.es.eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhlts...kenhra........nivvhcsagvg

RTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKLPSSIDFSGYEDSESD
|||.. .||. | |...   .|| |.|| .| ||   .|   || |.| ||.|    .    .  ||  | .  |.
rtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 325-590 9.5e-67 220.2 In-house 39-289 (515) alignment 
Range on Protein: 325-590
Range on HMM: 39-289/515.0
KHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGT
.  .| .|||| ..| || .|| | ..| .| |||.|| |. ...  .|.||.|| .. . .||| .... .  ||.| |.  |  . |||.|||   | 
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

SGEYGKISVANLEIETRRDYTITVLTVHNSTTneSRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyqstsvkeMGDEWTgHpggpPIVVHCSAGIGRT
| ..|.|.|  . .|.  . ..  |||  .    || .| |.|| ||| |.|. . ..| .  ||.           ...| |    |...|||||.|||
svkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevka........dhgqyt.h....pliihcsaGvGrt

GTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKLPSSIDFS
| ....|  .|. ..  ..|| |.|. .|..| | .|| .|| | | |. |.    . |   | |.
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihft
subfamily_PTPN13_pd Subfamily PTPN13 304-576 1e-66 220.0 In-house 12-268 (273) alignment 
Range on Protein: 304-576
Range on HMM: 12-268/273.0
GIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGdpysdYLNANYMDGYKQKN--AFIATQGALPKTFSDFWLMIWESQCRTIV
   .|.  .|   |  |   .|.. | .|||| .|| ||..|| |    |     |.||...    .|.   .||.|| ||.| .|||.|.|| ... |.
qPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MTTRTVERGRLKCGQYWPLEEGTSGE-YGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVkem
| |  .|.|..|| .||| ... .   .... |..|... . ....  |.|..| ..|||...|..|..||| |.|.||. .|.|  |||. |. .    
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag...

gdewtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
           ||||||||||||.||. |.|. |  .|    .|| ..|| .| ||   .|| ||| |.| |..| 
...........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPN1_pd Subfamily PTPN1 310-578 1.5e-66 219.0 In-house 13-272 (290) alignment 
Range on Protein: 310-578
Range on HMM: 13-272/290.0
AAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPilNGDPysDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVER
  || |    .  ..|.  |  .||| ||  |||||. |   ..|   ||.||. ..  . |  .| ||| ||.| . ||.|.|| .....||  . ||.
ldirkeasdfptreaklpenrnlnryrdvspydhsrikle..radn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvek

GRLKCGQYWPLEEG-T--SGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSvKEMGdewtg
...|| |||| .|       |  |..|  .. |... ||. .| ..| .|.|.| |.|| .|.||||| |.|  |.|.|  .||.  | | ...|     
eqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.sdvG.....

hpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVAT---IDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
     | |.||||||||.|||| .|  |...|.      .|. ...  .| .|   |||.|| .| |.|..| |.
.....pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 331-580 1.8e-66 218.9 In-house 22-267 (270) alignment 
Range on Protein: 331-580
Range on HMM: 22-267/270.0
HKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGT--SGE
. |||||.|   ..|| |. |. |. . |.||||. |... |...||..| || | ..|| ||||.. ..|||||  .|.|| || .||| | ..  . |
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

YGKISVANLEIETRRDYTITVLTVHnsTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQStsVKEMGDEWTghPGGpPIVVHCSAGIGRTGTF
.|||.|..|. | .. | .| |...  .. |.||..||....||| | ||..   |. .. ..  .   |... .|     .. |..||||||.|||||.
dgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlra..vrrsekeld..kae.PllvHcsaGvgRtGtl

CTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
 .||| .  ||    .|| . .. .| .|   .|.|.|||| | |.||||.| 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN23_pd Subfamily PTPN23 325-580 5.1e-66 217.4 In-house 39-283 (288) alignment 
Range on Protein: 325-580
Range on HMM: 39-283/288.0
KHRLNVHKNRYADVLCYDHSRVFLPilngDPYSDYLNANYMDGYKQK-NAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEG
  .|...|||. |.| |||.|| |     .   ||.|| .. .       |||||. |..| .|||||..| . ..||| .   |.|. |. .||| ..|
iaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

TSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKEMGDewtghpggpPIVVHCSAGIGR
 . ..|..||.  . ..   .   ||...   ... . ..| |.||||..| | |   .|.| .||..  ..  ...           |.|||||||.||
etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.........PlvvhCsaGvgR

TGTFCTLDISLARLEDVA-TIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
||.|. .   .. ||     .|. . |. .|.|| ...|. .|..|.| | .|.|.| 
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 302-578 5.2e-62 204.8 In-house 22-289 (325) alignment 
Range on Protein: 302-578
Range on HMM: 22-289/325.0
QSGIYKEYAAIRAEPPAGtFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIV
| |. .|.  . .. .   . .. .  |. |||. .|. .|.||| |  .. || |||.||.|.  .|.|. |.|.|  |..|  |.| .. . .|  .|
qdgfahefgllpsddgia.kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv

MTtRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyqstsVKEMG
..   .. |  .| .||| | | | ..| . |    ||.  ||   || | .    |.| .  ||. ||.|.|...   ... . . | .     |.|  
vl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka.....vserv

DewTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
   .   .  ||.||||||.||||.| .|   ||.. . . .|. . |. .|..|   ..| ||| ..| ||||.  
t..antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 313-580 1.1e-61 203.5 In-house 33-287 (297) alignment 
Range on Protein: 313-580
Range on HMM: 33-287/297.0
RAEPPAGT--FYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQknAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERG
.  | | .     .....| .|.||...| || ||| | |.| || |||.|| .. |.|.   .|.||   . |  ||| |... |  |||| .   || 
lclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerd

RlKCGQYWPleEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPR--SALAMLEFREEVRqyqstsvkemgDEWTGHP
. || .||.  . .. ..|..||  | .. |. .    |.| .. .   | .  .||..|||   .|  || ..|.. .|||           ... .. 
k.kcaryWs..dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr...........kdfsqna

GGpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
 | |..|||.||.|||| ..|.|  .|. ..  ..|. ..|. .| .| | .|| .||.| | |..|.    
eg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_PTPN14_pd Subfamily PTPN14 299-580 4.2e-61 201.6 In-house 19-299 (300) alignment 
Range on Protein: 299-580
Range on HMM: 19-299/300.0
NMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDpYSDYLNANYMDG--YKQKNAFIATQGALPKTFSDFWLMIWESQ
..... ...||  |  .   ......|   |..|||. ||| |...|| |   . .  ..|.||  .      ..  .|..|| |..|  ||| |.||..
kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqg

CRTIVMTTRTVERGRLKCGQYWPLE--EGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQS
 . ||| |.. | |. |. .|.| .  .  . |.||  | .   |.   .. | |...   ..| | . |.|.| ||| | |.    .|.. |||.  . 
vqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrr

TSVkemgDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
 .     .|  ..   ||..||||||.||||   . |. .| ||   .||. .... .| || . .||  ||.| | .|..| ..|
ktn....seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 308-580 5.1e-60 197.7 In-house 15-280 (287) alignment 
Range on Protein: 308-580
Range on HMM: 15-280/287.0
EYAAIRA--EPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTR
|. |..   |  . || |...  .|.|||||||| .|..||.|   .|.  |||.||||. .|....||||.|| .. |  ||| ...| .  .... ||
evdalkedsesstatfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

TVERGRLKCGQYWPLEeGTSGEYGKISVANLEIETR-RDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTsvKEMGDEw
 || .|||| .|||         |  ||  |. . .  .|..  | . .  |.|.| .  ... |||| . . .|.... |  .|.|.     .  ..| 
eveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel..ardase.

tghpGGPPiVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
     ||. |||...||||.|.. .. . . ||||.  .|| ..|  .| .||  .|.. |. . | ||| | .  
....vGPl.vvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 320-579 1.1e-58 193.4 In-house 37-285 (290) alignment 
Range on Protein: 320-579
Range on HMM: 37-285/290.0
TFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGD--PYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQY
| .      | ..||.|... ||  |. |  ..|.     .|.|| |..|||.|...||||| ...|  ||| .||. ..  ||| |  .| |. || ||
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WPLEeGTSGeYGKISVANLEIETRRDYTITVLTVHNSTT-NESRRITHFQFTSWPDFG-TPRSALAMLEFREEVRqYQStsvKemgdewtghPGGPPIVV
|| . .|.  ||..|.  |. ||  .|... | |.|... .... .|..|.|.|.. |  .  .  .| ..| ..  |    |         .|  .|||
Wpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk.tqr...k.........rgntsivv

HCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
|||...||...||...... . .    ||| . .. .| |.  |.|| .||.. .  ...| ..
HCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0051429 (Phosphotyrosine protein) phosphatases II 355-577 2.3e-54 180.1 In-house 2-225 (272) alignment 
Range on Protein: 355-577
Range on HMM: 2-225/272.0
PYSDYLNANYMDGYKQ---KNAFIATQGALPKTFSDFWLMiWESQCRTIVMTTRTVERGRLKCGQYWP----------LEEGTSGEYGKISVANLEIETR
|.|.| ||....|| .   ........| || |  ||| . .| ...|||. ....||||||| .|||           .. .. .||...| .|..|. 
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

RDYTITVLTVHNS-TTNESRRITHFQFTSWPDFGTPRSAlaMLEFREEVRQyqstsvkemgdewtghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDV
 ||....|....  ...|.|...|...|.|||.|.|..|  .||. |....                  | |..||||||..||||.. |...|..... 
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..................ggpvlvHCsaGkdRTGtvvallllllgvsle

ATID--------VCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
. .|        . ..|. .||||....||..||.|.| ||.|..
tivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 329-577 2.5e-54 179.2 In-house 47-278 (287) alignment 
Range on Protein: 329-577
Range on HMM: 47-278/287.0
NVHKNRYADVLCYDHSRVFLPilngDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGtsGEY
| .|||....| .|  || |     .   ||.|| ..||||.|.|||.... . .|  .|| .|.. .  .||| ..  |  . .| |||| |.     .
nkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvl

GKISVANLEIETRRDYTITVLTVHNST-TNESRRITHFQFTSWPDFG-TPRSALAMLEFREEVRQYQstsvkemgdewtgHPGGPPIVVHCSAGIGRTGT
|. ... |. |.  .|..  | |.|.. ... .... .|.|.|.. |  .. .  .| . | ... .             ..|  .||||||...||...
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr.............krgntsivvhCsdtvGrsam

FCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
||  .... . .   .||| . .. .| |.  |.|| .||.| . ...|| 
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 323-575 5.1e-54 178.0 In-house 2-239 (239) alignment 
Range on Protein: 323-575
Range on HMM: 2-239/239.0
ASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPle
|.|.|.|  |||||... |||||| |  |. ||.|||.||.|.  |    .|.|||||..  .  ||| |.|. .   ||| |  .|  . || ||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..

EGTSgEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyqsTSVkemgdewtghPGGPPIVVHCSAGI
. || .| .. |.  . |   || |  . . .    | | . ...|| ||| | |. | |.| .| .. .    |.          ||  | |.|||||.
dsts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dsl..........pgarpwvihcsagv

GRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVE
||||.|  .|  | . .   |.|. | |. .| .| . .|| .|| | ..|..|
grtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 323-575 5.1e-54 177.9 In-house 1-238 (239) alignment 
Range on Protein: 323-575
Range on HMM: 1-238/239.0
ASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPle
|.|.|.|  |||||... |||||| |  |. ||.|||.||.|.  |    .|.|||||..  .  ||| |.|. .   ||| |  .|  . || ||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..

EGTSgEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyqsTSVkemgdewtghPGGPPIVVHCSAGI
. || .| .. |.  . |   || |  . . .    | | . ...|| ||| | |. | |.| .| .. .    |.          ||  | |.|||||.
dsts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dsl..........pgarpwvihcsagv

GRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVE
||||.|  .|  | . .   |.|. | |. .| .| . .|| .|| | ..|..|
grtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRN_pd Subfamily PTPRN 305-575 1.2e-53 176.7 In-house 31-290 (297) alignment 
Range on Protein: 305-575
Range on HMM: 31-290/297.0
IYKEYAAIR---AEPpaGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANY-MDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTI
. ||. |.    |||   |  ..|.  ||.|||...|| |||||| |   . .  |||.||   .|   .. |.||||| |..| .||| |.||. .  |
lekewealcayeaep..stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMTTRTVERGRLKCGQYWPlEEGTSgEYGK--ISVANLEIeTRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyqstSvk
|. ||  | |  .| .||| .||..  |.   . .    |    || .  . . |  |.|.| .| | | |||. |.| || ..||||  | .    |  
vnltrleeegvkqckrywp.deGse.vyhiyevhlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk....s..

emgdeWTGhpGGPPIVVHCSAGIGRTGTFCTLDISLARLE-DVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVE
     . |     |||||||.| ||||... .|. |.||   |  ||.. |.  .| ||.  ..| ||.||.. |..|
.....yrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_CG7180_pd Subfamily CG7180 314-576 1.4e-53 176.4 In-house 27-289 (296) alignment 
Range on Protein: 314-576
Range on HMM: 27-289/296.0
AEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRlK
..   |.  .  .  |  |||. .|. ||. ||.|. |.|.  |||.|| |.|.. .|...| |..   .|  .|| .... .. ..|. |.| .  . .
prleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.m

CGQYWPLEEgtSGEYGKISVANLEIETRRDYTITVLTVHNS----------TTNESRRITHFQFTSWPD-FGTPRSALAMLEFREEVRQYQSTSvkemgd
. .||| .     .||.| |  .| ..  . .|  . .              . | | ...||.| |.     | |. |..|.|. ||...         
ypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv......

ewTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
    .|   |.||..| | .|.| ....|..|  .|    .|| . |. .| .|   ... ..| ..|  | |.
..dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 329-574 1.5e-53 176.5 In-house 3-236 (237) alignment 
Range on Protein: 329-574
Range on HMM: 3-236/237.0
NVHKNRYADVLCYDHSRVFLPILNGDpySDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEgTSGE
|  ||||... .||||||.|    ..  |||.||.|..|.    . .||.|| |  .  ||| |.|. .|  ||| |  .|. .||| .|||  .     
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

YGKISVANLEIETRRDYTITVLTVHN-STTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyQSTSVKEMGdewtghpggpPIVVHCSAGIGRTGT
||...|.    |   |||.  |.. .  | .| | |  .||||||| | |. . |.| || .. . .|  | | |          | ..|||||.|||| 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin.rsphvsesg..........pwiihcsagvgrtgi

FCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALV
|  .|  | . ..   .|. | |  .  .| | ||| ||| | . ...
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 326-581 5.3e-52 171.4 In-house 30-270 (283) alignment 
Range on Protein: 326-581
Range on HMM: 30-270/283.0
HRLNVHKNRYADVLCYDHSRVFLPILNGdpysDYLNANYMD---GYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPlEE
 . | .|||. ... .|  || |  ..     ||.|| ..     |||.. .|..|. | .|  ||| |... .  .||| |.  |  | || |||| ..
adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP.kr

GTsGEYGKISVANLEIETRRDYTITVLTVHNS-TTNESRRITHFQFTSWpdfgtprsalamLEFREEVRQYQSTSVKEMGDEWTGHPGGpPIVVHCSAGI
|.  .||.  |.  .  | . ..|  |..... .....  ..|.|.  |            ||. |.        .  .    | .. | |||||||.||
Gs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW............leygeqaiinslvkfnkvislqteskkg.PivvhCstgi

GRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSD
|||..|...  |.  .   . .|| ..|. || ||   .|| ||| . . . .| |   |
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgd
0041856 (Phosphotyrosine protein) phosphatases II 329-580 2.7e-50 165.8 In-house 1-174 (182) alignment 
Range on Protein: 329-580
Range on HMM: 1-174/182.0
NVHKNRYADVLCYDHSRvflpilngdpYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTrtvergrlkCGQYWPleegtsgey
|..|||| |.|.|||||          ..|| |||...|.   . |||||| |..|. ||. |..| ...|||. |         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gkisvanleietrrdytitvltvhnstTNESRRITHFQFTSWPDFGTPRsALAMLEFREEVRQyqstsvkemgdewtghpGGPPIVVHCSAGIGRTGTFC
                           ... | ........|||.|.|     .|.| |||..                  | |..||||||.|||||..
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlv

TLDISLARledvaTIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
 ... . .      ... ..|.|.| .|  ...||.|| |.. || |. ...
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 291-577 9.1e-50 163.9 In-house 15-283 (290) alignment 
Range on Protein: 291-577
Range on HMM: 15-283/290.0
EALVSYVLNMRQSGIYKEYAAI-RAEPPAGTFYASKHRLNV--HKNRYADVLCYDHSRVFLPilNGDPySDYLNANYMDGYKqkNAFIATQGALPKTFSD
| . | | ..   .. |||    .   |.. .  .    |   .|||| || | | .|| |   .| .  ||. |||..| |    || ||||| .|  |
ekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGlk..amfiltqGalkdtvid

FWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTI-TVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFR
.| |. . .  .|||    .| |. || ||.| .||    .|.|.|   | ... . .|  .|.| .  .  . .. |..  ||||   . |.||.|   
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtl

EEVRQyqstsvkeMgdewtghPGgpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
  .|.        .       .|  |.|||||||||||||| .....|  | |   .|. ..|| .|  |. |.|   ||     .|... 
rilrk........a.......sG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
0049772 (Phosphotyrosine protein) phosphatases II 313-583 8.1e-49 162.4 In-house 30-286 (314) alignment 
Range on Protein: 313-583
Range on HMM: 30-286/314.0
RAEPPAGTFYASKHRLNVHKNRYADVLCYDhSRVFLPILNGDPySDYLNANYMDGYkqkNAFIATQGALPKTFSDF----------WLMI--WESQCRTI
   .|..|...... || .|||| |.|..| .||.|| |...  ||| ||.|.||.   ..|||||| |. |. ||          | |.  .. ..|.|
lsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------TTRTVERGrlkcgqywpleegtsGEYGKISVANLEietrrdytitvlTVHNSTTNESRRITHFQFTSWPDFGTPrSA
||                      ..  ..|               .|.    ...|.            .....    .|.. ..  . .||...| . 
vmsrdevladelsrLdaAlgKtpllildgng...............neptaadlellk............eelydpelferlgikylripvpDgsap.ll

LAMLEFREEVRQYqStsvkemgdewtghpGGPPIVVHCSAGIGRTGTFCTLDISLARLedvaTIDVCNTVRLMRAQRA-----YSIQTPDQYEFCYFALV
  ..|| | .... .               | |..|||.||.||||||..... . .|     ...  ... .|..|       .|....||||.. || 
edfdeflefieea.d..............kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileall

EYAQRSDKL
|| ..  | 
eylkflkkf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 293-577 3e-48 159.4 In-house 6-277 (307) alignment 
Range on Protein: 293-577
Range on HMM: 6-277/307.0
LVSYVLNMRQSGIYKEYAAIRAEPPAGTfYASKHRLNVHKNRYADVLCYDHSRVFLPIlNGDpYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMI
 |   |..  . .  |.  .    | |   .   . | .|||| || | |..|. . . .|   |||. |||.    . . ||..|| | .|  .|| |.
wvqrtldkgvqalvdefrvlakktpegv.tveafsantdknryqdvkcqdkgrivvkf.dgl.asdyihanylgiaikpkkficaqgplentqysfwama

WESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGK----ISVANLEIETR--RDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFR
 . .  ...|  ...| ...|| ||||||||    .|.    |||||| ...    .  | | |..   ...|| |.|.|.. ||| |.|.  |. ... 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll

EEVRQYQStsvkemgdewtghpggpPIVVHCSAGIGRTGTFCTLDISLAR-LEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
| ||  .                  |.|||||||.||.||  .. .   . .. .   |. . |. .|.|| |.|||  || . .  |.|| 
eavrydtn.................pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 310-576 4.8e-48 158.7 In-house 27-278 (439) alignment 
Range on Protein: 310-576
Range on HMM: 27-278/439.0
AAIRAEPPAGTFYA--SKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTV
  | .  |  .  |    .  .  |||| ||  .||.|| |  . | |.| |.||||..|| ... .|||||   .|  ||| ...| .. |||| |  |
ekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlv

ERGRlkcgqYWPLEEGTSgeYGKISVA-NLEIETrRDYTITVLTVHNS--TTNESRRITHFQFTSWPDFGTPRSALAMLEFreeVRQYQSTSVK-EMGde
|  .     ||| .. .   || |.|  . .||   .|.|  . | |   ||.  | . .|....|||   |  |  .|.|   .|  .|.  | |.|  
esyk.....ywpsdaevc..ygdiavrvdrniel.pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf...lrainsandkeeyg..

wtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
        |.|||||||.|||||  .|||.| .|     .|.   |...| ||   .|.  || | | |..| 
........pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 307-573 1.2e-47 157.2 In-house 11-291 (297) alignment 
Range on Protein: 307-573
Range on HMM: 11-291/297.0
KEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpiLNGDPYSDYLNANYMDGY--KQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTT
.|. ..  |  ...| ..|    ..|||| |.| .| .|| |  |.. . .||.||.|.     ...  .| .|| | .|  ||| ...| . |.||| .
aekdllldeargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva

RTVERGRLKCGQYWPLEEGTSGEYGKISVANLEiETRRDYTITVLT-VHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVR-------------
.  | || ||  |||  ..   . |.. |  |  .|  ..   .|| ..    .||| ..| || |||| | |     .  |. .|              
klqedGrdkcapywpsvvqerlkagdvvvefls.stsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalv

-QYQSTSVKEMGDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFAL
  . .  . ..    . .|   ...||||||.||.|     |. ||.|      ||   .. .| |||  .|| .|.|..| | 
emftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
0036282 (Phosphotyrosine protein) phosphatases II 357-570 1.9e-45 150.0 In-house 2-163 (174) alignment 
Range on Protein: 357-570
Range on HMM: 2-163/174.0
SDYLNANYMDGYKQKNAFIATQGALPktfsdFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLeegtsgeygkisvanleietrrdytitvltvhnSTT
|||.||...|..   . .||.|| |.     || |..| ...|.|| .. .|.|. || .|||                                    .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

NESRRITHFQFTSWPDFGTPRSALaMLEFREEVRQYQstsvkemgdewtGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEdVATIDVCNTVRLMRAQR
 ..| . ..... |||.|.| ..  .||| ..|....             ...| |..||||||.|||||.. ... | .|.   ..|....|| .| ||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveeal............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqr

AYSIQTPDQYEFCY
 ...|||.||.|.|
pgmvqtpsQyrfly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 294-590 2.6e-45 149.5 In-house 10-249 (392) alignment 
Range on Protein: 294-590
Range on HMM: 10-249/392.0
VSYVLNMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIW
 ..| . |.| .. |      .|..    ....  |..|||| ..| || .|| | ...  | |||||| |........|.||.||  . ...||| |..
pafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

ESQCRTIVMTTRTVERGrlkcgqywpleegtsgeygkisvanleietrrdytitvltvhnsTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyq
. .  ||.| |.  |                                                .. | .. |.|| ||| . |. . ..|.| .||.   
qenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka..

stsvkEMGDeWTgHpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDKLPSSIDFS
     . |. .| |    |...|||||.||||   ..|  .|. . .  .|| | |  .| .| | .|| .|| | | |..|     . |   . |.
.....dfGq.yt.h....pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhft
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 301-578 4.2e-44 145.4 In-house 13-294 (301) alignment 
Range on Protein: 301-578
Range on HMM: 13-294/301.0
RQSGIYKEYAAIRAEPPAGTFYaSKHRLNVHKNRYADVLCYDHSRVFLPILNG--DPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCR
.. .. ..| ... . .  .   . .  | . ||. ..  ||. |. |   .       .|.||.|.|||..|..|||.|| . ||  ||| .||. .  
hsnkfeeqykelkegedksctv.glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVH---------------NSTTNESRRITHFQFTSWPDFGTPRSALAML
.||| | . |. . || ||||  | .| |.|...|   .  .  |..|  |.|.                .....|. .. .| |.||. |  |    .|
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

EFREEVRQYQStsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
.  ..| . |              .|| |.|||||....|.|..|...|.|        .|| . .. .| ..   ..| .|| . | .. .| |
qviddvihrqq............kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0043147 (Phosphotyrosine protein) phosphatases II 353-570 9.6e-44 144.5 In-house 1-154 (172) alignment 
Range on Protein: 353-570
Range on HMM: 1-154/172.0
GDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTvergrlkcgqywpleegtsgeygkisvanleietrrdytitvltvH
||..||| ||.|.|.|   . |||||| |. |..||| |..| ....||. |.                                               
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

NSTTNESRRITHFQFTSWPDFGTPrSALAMLEFREEVRQYQ--STsvkemgdewtghpgGPPIVVHCSAGIGRTGTFCTLDISLarledvATIDVCNTVR
. .....| . ......|||.|.| ..  .||| | .....  |               | |..||||||.|||||.. ... |        ... ..|.
ydpellerlgiqylylpwpDhgvp.llellleflefidellalsp..............ggpvlVHCsaGvgRtgtlvaaylml......lglsleeava

LMRAQRAYSIQTPDQYEFCY
|.|..| ...|.|.|| |.|
lvrekRpgavqnpsqyrfly
subfamily_ptpA1_pd Subfamily ptpA1 326-538 7.9e-43 141.7 In-house 44-257 (418) alignment 
Range on Protein: 326-538
Range on HMM: 44-257/418.0
HRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNaFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTS
.. |  ||||...|  .|.|| |  ..    |||.||||.||   |. ||.||| ||.| .||| |.|| .|| ||| .|  |  |.|| .||| . |  
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

---------GEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKEmGDEwtghpgGPPIVVH
           .|  ||  .|.    .  |    .. .   |.| ||..|.  |||.  |  .  . ..   . . |   .    |         ||.||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiips.sdr......nvpiivh

CSAGIGRTGTFCTLDISLARLE
||||.||||||||  | . .|.
csagvgrtgtfctavimmkkld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 327-577 1.4e-42 140.4 In-house 53-289 (305) alignment 
Range on Protein: 327-577
Range on HMM: 53-289/305.0
RLNVHKNRYADVLCYDHSRVFLpilNGDPYSDYLNANYMDGY-KQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTS
 ... ||||.|| | |.| | |   .  . |||. |||.      .. ||..|| | .|  .|| |. . .   |||  .||| |.||| ||||.  |  
diaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

GEY-GKISVANLEIE--TRRDY--TITVLTVHNStTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQstsVkemgdewtghpggpPIVVHCSAG
 |  . | | |.       ||    ||.| .  |  ...  . |.|.| ||| | |   |. ||.   .|  .   |              |||||||||
lelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgsk...v..............pivvhcsag

IGRTGTFCTLDISLARLE-DVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
||||||  ...  | ..  .     . . |. .| |||.|||.  || | .  ...| 
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0046846 (Phosphotyrosine protein) phosphatases II 349-577 3e-41 136.4 In-house 4-173 (176) alignment 
Range on Protein: 349-577
Range on HMM: 4-173/176.0
PILNGDPYSDYLNANYMDGYKqknaFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGeygkisvanleietrrdytitv
 .|  |...||.|||...|..    .||||| ||.|. ||. |..| .....|. |  || ||||| .|||..|. .                       
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

ltvhnsttnesrritHFQFTSWPDFGTPRSaLAMLEFREEVRQYQstsvkemgdewtghPGGPPIVVHCSAGIGRTGTFCTLDisLARLEdvATIDVCNT
               ..... |||.|.| .  ..||. |..|...                | |..||||||||||||.. ..  | .||    ..| ..
...............qylhlpwpDhgvpdl.elllellefireal..............keggpvlVHCsaGigRtgtlvaay..llele..kglsveea

VRLMRAQRA-YSIQTPDQYEFCYFALVEYA
..|.|.||  ...|||.||.|.| .. .. 
lalvreqRplgavqtpeQyrflyefellll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 292-581 1.2e-39 130.9 In-house 11-291 (305) alignment 
Range on Protein: 292-581
Range on HMM: 11-291/305.0
ALVSYVLNMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLpilNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLM
 .|  .|.    |. .|..|..       . | |.  . .|||| || | |. || |   .|    .|. |||.    . . || ||  | || .||| |
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwym

IWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEY----GKISVA-------NLEIETRRDYTITVLTVHNStTNESRRITHFQFTSWPDFGTPRSAL
 .. .  .| |    .|.|  || .|.. ...   |.     ||||        ... ... . | |||..  .  ...|..||. .  ||| | | . |
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadl

AMLEFREEVRQYQstsvkemgdewtGhpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNT-VRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
|.||. |. |  .            |     ||||||||||||||.   |.  | .|     |. ..  .. .| ||  |||| .|| | .  ...| ..
ailellekarpsk............g.....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

SD
 .
kk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 304-576 1.5e-39 130.4 In-house 12-268 (281) alignment 
Range on Protein: 304-576
Range on HMM: 12-268/281.0
GIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPI-LNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVM
 . .|.. .  .||.    . .. .| .||||... | | ||| | . .     .||. |||.     |  .| |||   .| .||| |||. .  .|||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

TTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLtvHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyQSTsvkemgd
  . .|  | || .|.| .     .. |.||.  .    .    | |    |   |.| |||. .  |||.  | |.  ||.   ..|  .||       
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrl..nlsyegetrlithwlwkewpdwqvpessevmlkilrkira.rst.......

ewtghpggPPiVVHCSAGIGRTGTFCTLDISLARLEDVATI-DVCNTVRLMR-AQRAYSIQTPDQYEFCYFALVEY
        || |.|||||.||.||. ...|.|  .    |. |. . |  .| . || |.|| .|| . .  |...
........pp.vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049260 (Phosphotyrosine protein) phosphatases II 364-570 4.4e-39 128.9 In-house 1-143 (152) alignment 
Range on Protein: 364-570
Range on HMM: 1-143/152.0
YMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWpleegtsgeygkisvanleietrrdytitvltvhnsttnesrrit
..|||.....|||||| .| |..||| |..| ...|||| |. .|.|.||| ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFQFTSWPDFGTPRSALAMLEFREEVRQYqstsV----KemgdewtghpggpPIVVHCSAGIGRTGTFCTLDISLarledvATIDVCNTVRLMRAQRAYS
..... |||.|.| ..  .|.. . ....         .             |..||||||.|||||.. ... |        ... ..|.|.|..| ..
qylhlpwpDhgvpdlsqlllflllfiekl....aldkgg.............pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpga

IQTPDQYEFCY
...|.|..|.|
vpnpgqlrfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 316-577 9e-39 128.1 In-house 24-270 (285) alignment 
Range on Protein: 316-577
Range on HMM: 24-270/285.0
PPAGTFYAskHRLNVHKNRYADVLCYDHSRVFLPilNGDpySDYLNANYMD-GYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKC
||  |. |  .  |   |||||| | . .|| |   | |   ||. |..|    |.....|.||| ||.|.|||| ||.. .   ..|    .| |  ||
ppnctyta..yeanpdlnryadvrcieetrvvlk..nhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

GQYWPLEEGTSGEYGKISVANLEI--ETRRDYTITVLTVHNS--TTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYqstsvkemgdewtgHPGG
  |.| . |   ..||  ..  |   |.     .  ||| |.  ...|   . | |   |||  .|  |  |.|. . |..                |  
alyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..............npke

PPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
 ||.||||||.||| ||  .| .  |. .   |.. . || ||| |  ..|.  |. | |  |.|| 
kpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 303-580 1.3e-38 127.3 In-house 27-293 (310) alignment 
Range on Protein: 303-580
Range on HMM: 27-293/310.0
SGIYKEYAAIRAEPPAG-TFYAskHRLNVHKNRYADVLCYDHSRVFLPIlNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIV
 |. |.|  . |.  .  |. |  .. ..|||||.||.| | ||| | | .   | ||. |||.     ...|| .|| | .|  ||| ||.. .. .|.
eglvkqyrkldakqdssltyea..ykkymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MTTRTVERGRLKCGQYWPLeEGTSGEYGKISVANLEiETRRDYTITVLTVHNS----------TTNESRRITHFQFTSWPDFGTPRSALamlefrEEVRQ
.  ...| || ||  |||   | .  || | |.||  |.  .. |  |.|             .  .  |..  ..  ||| | |            | |
llckvgeegrpkcvgywps.lgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpq

YQSTSVKemgdewtgHpgGpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
   . |.        |  | | |||||||..|... ..|.... .|.    .|. . .  .. .||  |||. || .  .  . .|.  
rllaqvr........h..g.pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarge
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 328-579 7.2e-38 125.1 In-house 32-261 (267) alignment 
Range on Protein: 328-579
Range on HMM: 32-261/267.0
LNVHKNRYADVLCYDHSRVFLPILNGDpysdYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVErGrlKCGQYWPLEEGTSGE
 |  .||. |.| ||..|| |   . .    |.|| |..|||.|||||.||..| .| .||. .| . .. .||. |.. . .  .  ..|| . | . .
knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.d..nirlfwPPkmgqakk

YGKISVANLEIETRRDYTITVLTVHNstTNE-SRRITHFQFTSWPDFGTPRSALAMLefreevrqyQSTSVKEMGDEwtghpGGPPIVVHCSAGIGRTGT
|  ..|     .   || | .| ..    || .. .| . .  |      .  |  |              |.  ..     |..|.||.||.|.||.||
yqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl.........fgilaknqlen.....gnrPlvvacsdGvGrsGt

FCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
| ..|  | |.    . |. . .| .| ||   ..| ..| ...  |.|||. 
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
0051082 (Phosphotyrosine protein) phosphatases II 355-574 8.7e-36 118.1 In-house 1-150 (151) alignment 
Range on Protein: 355-574
Range on HMM: 1-150/151.0
PYSDYLNANYMDGYkqknaFIATQGALPktfsDFWLMIWESQCRTIVMTTRTVERGrlKCGQYWPLEEgtsgeygkisvanleietrrdytitvltvhns
|.|||.|..|..|.     .....| |.    ||. ...| ...|||. . ..|||  .| .|.| ..                                
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

ttnesRRITHFQFTSWPDFGTPRSALAMLEFREEVRQyqstsvkemgdewtghPGGPPIVVHCSAGIGRTGTFCTLDISLARledvatIDVCNTVRLMRA
     ....|.....|||.|.| |  |.||| |....                ... |..||||||.|||||.. |.. | .      ...  ... .|.
.....ievlhipildwpdpglplsfdavleflellld................kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrl

QRAYSIQTPDQYEFCYFALV
.| ...|...|. |..||| 
krpgvvqpnqqflfqlfall
0044763 (Phosphotyrosine protein) phosphatases II 340-580 1.4e-35 117.9 In-house 1-174 (178) alignment 
Range on Protein: 340-580
Range on HMM: 1-174/178.0
CYDHSRVFLPILNGDPYSDYLNANYMDGYkqknAFIATQGAlpktfSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGtsgeygkisvanleie
..|..||.|. | | ..|||.||......     .......     .|.. ...|  ...||. | ..|.|.||| .||| |.|                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

trrdytitvltvhnsttnesrriTHFQFTSWPDFGTPRSALAMLEFREEVRQYQstsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLARled
                        ..... .||.|.| .   .||| | .....             .. | |..||||||.||.||.. ... . .   
.......................iqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaaylmkkl...

vaTIDVCNTVRLMRAQRAySIQTPDQYEFCYFALVEYAQRS
   ... . ..|.|..|   ...|.|....|    .. . |
..glsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
subfamily_CG42327_pd Subfamily CG42327 331-497 9.8e-33 108.1 In-house 30-199 (319) alignment 
Range on Protein: 331-497
Range on HMM: 30-199/319.0
HKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQ-KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSG--E
 |.|...|.   ..|| |.    |. . ||.|.|. ||.. .| .||.| .| .. |||| ..|| | |.||  |   | |  .| .|.| .|.  .   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFtSWPDFGTPRSALAMLEFREEVRQY-QSTSV
||.| |.  . |..  | |. | ...   .||| .||. .  |.. . | .  |..    |||.  .| |.
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslksysl
PTPc_DSPc_SM00012 462-574 1.6e-32 107.2 In-house 2-104 (105) alignment 
Range on Protein: 462-574
Range on HMM: 2-104/105.0
ITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTSVKemgdewtghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDV-ATIDVCNTVRLMRAQRAYSI
..|...|.|||.|.|... ..||. ..|.. .. | .           ..|.|||||||.||||||..||| | .||.   ..|....|. .| ||. ..
vkhyhytgwpdhgvPeesdsilellravkknknkses...........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmv

QTPDQYEFCYFALV
|| .|| |.| || 
qteeqylflyrall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 290-576 7.2e-32 105.6 In-house 6-270 (288) alignment 
Range on Protein: 290-576
Range on HMM: 6-270/288.0
IEALVSYVLNMRQSGIYKEYAAIRAEPPAgtFYASKHRLNVHKNRYADVLCYDHSRVFLPilngDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFW
| | . .||..   |. |||     | .     ....  |  ..|| .. . | .|| |     |    | .|| .   | |. .| .|  |  |   .|
inawirlvlqiaveglkkeyrdspneasi..diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelW

LMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRR-ITHFQFTSWPDFGTPRSALAMLEFREE
 |. ||. . ||| .. .|.|. |  .|.|.. | .  .|..     .  .  | ...| ....| . | .  . .  .  |.| | | . |. | . | 
kmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllev

VrqyqstsvK---EmgdewtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
.        |   .            |||||.|||.|||||.    | |  |  .  . . . .  .|..|  .|||  || . .  . |.
l........kslqk............PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 369-570 9.3e-32 104.8 In-house 2-197 (199) alignment 
Range on Protein: 369-570
Range on HMM: 2-197/199.0
KQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTN--ESRRITHFQ
| .  .|||| .| .|..||| |.||.    |||              |||  | ..|.|| .||.   | |. |||||.| . |.||    .| |.|.|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDFGTPRSALaMLEFREEVRQyqsTSvKEMGDEWtghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDVAT--IDVCNTVRLMRAQRAYSIQTPD
|||| .  ||  || .. |    |.    | |   .|        |..|||| | | || | .||| .   |.  |  .|. .  . .|  |   | . .
ftswkekttpnval.fvgfvvasre...vs.kkyeqek.....dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QYEFCY
.|.| |
hynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 371-570 1.4e-31 104.3 In-house 3-196 (198) alignment 
Range on Protein: 371-570
Range on HMM: 3-196/198.0
KNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTN--ESRRITHFQFT
.  .|||| .| .|..||| |.||.    |||              |||  | ..|.|| .||.   | |. |||||.| . |.||    .| |.|.|||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDFGTPRSALaMLEFREEVRQyqsTSvKEMGDEWtghpgGPPIVVHCSAGIGRTGTFCTLDISLARLEDVAT--IDVCNTVRLMRAQRAYSIQTPDQY
|| .  ||  || .. |    |.    | |   .|        |..|||| | | || | .||| .   |.  |  .|. .  . .|  |   | . ..|
swkekttpnval.fvgfvvasre...vs.kkyeqek.....dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

EFCY
.| |
nfiy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 324-566 5.4e-31 102.5 In-house 45-270 (301) alignment 
Range on Protein: 324-566
Range on HMM: 45-270/301.0
SKHRLNVHKNRYADVLCYDHSRVFLpILNGDPYSdyLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEG
|   |. .|.||  | |  .. | . | .|      . ||...   . . |||||| |..|  ||| |.   .  .||| ...||.   || .| |.. .
syaylpkdkhryptvPckPstavev.ivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

TSGEYGK--ISVANLEIETRRDYTITVLTVHNSTTN-ESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQStsvkemgdewtghpggpPIVVHCSAG
 . . |.  | . | |   . . .   | |..|| . ..| .||.|...|.| |.|.|   . .. | |.. .                  |||||||||
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.................PivvhcsaG

IGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQY
|||. .| . ..   ..|   ||.. .... .| .|  ..||  | 
iGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
0048076 (Phosphotyrosine protein) phosphatases II 417-574 1.3e-26 88.4 In-house 2-140 (145) alignment 
Range on Protein: 417-574
Range on HMM: 2-140/145.0
YWPLEEGTSGEYGKISVANLeIETRRDYTI-TVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTsvkemgdewtghpgGPPIVV
||| |   .  .| . .|.  .|. .|. | |||.. . .....| ........|||.|.| ..  .||| | ......               | |..|
ywpseilpglylgslptald.lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..............ggpvlV

HCSAGIGRTGTFCTLDISLArledvATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALV
|||||.|||||.. ... |        ... ....|.|.|| .....|.|..|.| .. 
HCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 331-577 1.6e-25 84.5 In-house 45-276 (312) alignment 
Range on Protein: 331-577
Range on HMM: 45-276/312.0
HKNRYADVLCYDHSRVflpILNGDPySDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTS-GEYG
  ||| .. |.|  |     | ||    |. ||..    . . |..|||.| .| . || .     . .|.. .  || |  || .|     |    |  
dlnrypniqcwdrgrf...tlagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

K---ISVANLEIETRRDYTI--TVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFReevrqyqStSVKEmgD-EwtghpggpPIVVHCSAGIGR
.    .....||  .    |   || |   .| .  .. |.|..|||| | | |  . | .        | .||   |          |.. |||||.||
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll.......s.avkk..dkk........pviahcsagvgr

TGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYA
|||.. ..  .| |      .| ..  |.| .|| |...  || ..  ...|. 
tgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 366-574 7.4e-25 82.2 In-house 230-435 (440) alignment 
Range on Protein: 366-574
Range on HMM: 230-435/440.0
DGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERgrlKCGQYWPLEeGTSGEYGKISVANLEIETRRdyTITVLTVHNSTTNESRRITHF
.|| .||||||||  |  |  ||| .. . .  ||.|  .  ..    |  |||..   |  .| ..|     |      . | |.     .|   |  |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn.trsvtfgpftvghkgsenmn..rvkvrtlelkykeevheirqf

QFTSWPDFGTPRSALAMLEFREEVRQ---YQSTSVKEMGDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQT
.  .|| .       .  .  . | |   |      .   | .    ||||.||| .||  .| |||.   | .|..  .||| . .||.|  |   . |
evqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvpt

PDQYEFCYFALV
  .| .||  | 
ltdyllcykllt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 328-576 1.1e-24 81.6 In-house 46-278 (303) alignment 
Range on Protein: 328-576
Range on HMM: 46-278/303.0
LNVHKNRYADVLCYDHSRVFLPilngDpySDYLNANYMDGYKQKNAfIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEG-TSG
 |..|||..||.| |||.| |     |  | |. |.|..   .|.| | ||  |..| .||| || | . . ...     |  .|     .| ..     
knmdknrfvdvicldhskvkls....d..ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

EYGKISVANL-EIETRRDYTITVLTVHNSTTNESRRITHFQftSWPDFGTPRSALAmlEFREEVRQYQSTSVKEMgdewtghPGGPPIVVhCSAGIGRTG
|   | | .. ..|    ... ||.| | . .    . |..  .||    |  . .  .|  .. | ||   |         .. |.. .   .| ||.|
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgsp..kfvkqiwqlqsvlrkys.......dstptvym.slsgcgrag

TFCTLDISLA-RLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEY
||. .. .     .. |..|. . .  .|  | ...|   |. . |  | |.
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
0048179 (Phosphotyrosine protein) phosphatases II 447-571 1.7e-23 78.3 In-house 32-139 (144) alignment 
Range on Protein: 447-571
Range on HMM: 32-139/144.0
TVLTVHNSTTNE--SRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYqstsvkemgdewtgHPGGPPIVVHCSAGIGRTGTFCTLDISLarledVATID
||... ..  .|   | ........|||.|.| ..  .||| | ....              .. | |..||||||.|||||...... .     .  ..
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea..............leeggpvlVHCsaGvgRtgtlvaaylmk.....klgls

VCNTVRLMRAQRAYSIQTPDQYEFCYF
. ....|.|..| .....|.|..|.. 
leealalvrsrrpgavpnpgqlrfLle
subfamily_egg_pd Subfamily egg 324-468 5.5e-23 76.1 In-house 35-180 (307) alignment 
Range on Protein: 324-468
Range on HMM: 35-180/307.0
SKHRLNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERgrLKCGQYWPLEEG
.    | .| |   | | | ||| | . .|    |.. ||...|    | || .|  |  |  ||| |... ... ||| | ..|    .|  |||  | 
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

TSGEY--GKISVANLEIETRRD--YTITVLTVhNSTTNESRRITHFQFT
 |  .  | . . ||... . |  ...| | .   . .| | . |.|  
dslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqgd
CRAL_TRIO CRAL/TRIO domain 1-84 5.7e-21 63.3 Pfam-A 69-159 (159) alignment 
Range on Protein: 1-84
Range on HMM: 69-159/159.0
MTGSSFTNFD---LTMSKKLLGMLRDGYPARLKRIYVVTPPLWFKAMYKILTPMLKEKMKERVTLVSAE----RLCRYLPATSLPKDLGGT
|.| |. ...   . . ||.| .| | || ||..|..| .| .||...|.. |.|.||..|....|| .     |  | .. .||| ||||
mkglslskmlwkpisllkkilkilqdnyperlgkilivnaPklfkvafklvkpfldektreKikfvspsntpatlekyidpeqlpkelGGt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 331-419 1.4e-20 68.3 In-house 49-151 (350) alignment 
Range on Protein: 331-419
Range on HMM: 49-151/350.0
HKNRYADVLCYDHSRVFLP--------ILNGDPYSDYLNANYMDGY----KQKNAF--IATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQ
 |||| ..| |.|||| |.        .      .||.||||.       ...  |  ||||. ||.|. ||. .| . . . |.. |  || .. || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWP
||.
YWq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 294-582 4e-20 66.4 In-house 17-290 (302) alignment 
Range on Protein: 294-582
Range on HMM: 17-290/302.0
VSYVLNMRQSGIYKEYAAIRAEPPAGTFyASKHRLNVHKNRYADVLCYDHSRVFLPilngDPYSDYLNANYMDGYKQKNAFIATQGALPKTF---SDFWL
...| .. .. . ||. .| .         . .. |..||.  || ..|. .| |.        .|.||  ..  . ..  | .| .  ..     .|| 
kklvksldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWr

MIWESQCRTIVMTTRTVERGRlKCGQYWPLEEGTSGEYGKISVANLEIETRRDYT-ITVLTVHNSTTNESRRITHFQFTSWPDFGTPRSALAMLEFREEV
|... .. ..|.  .. |  .    ...|.. |.  ||||. | |  .|   . .   |. |      .|  ..   .| |..   | .  .. .  ..|
mvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

rqYQStsvKEMGDEwtghpggpPIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRSDK
  ...   |. .||        ..|.    |.|| |.| || ... .|.. .   . ..|. .|.||. .... .|| . | ||. | ..  .
..fak...kikade........ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
subfamily_CG42327_pd Subfamily CG42327 512-578 1.9e-18 61.2 In-house 249-316 (319) alignment 
Range on Protein: 512-578
Range on HMM: 249-316/319.0
PIVVHCSAGIGRTGTFCTLDISLARLEDV-ATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
|.||||| |.||||.  . ||.. .||.   ..|. ..|  .| .|| ...| .|||| |  | |||.
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_eak_pd Subfamily eak 325-580 4.4e-18 59.8 In-house 48-308 (332) alignment 
Range on Protein: 325-580
Range on HMM: 48-308/332.0
KHRLNVHKNrYADVLCYDHSRVFLPILNGDPySDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGT
.   .|..|   ... ||.  | |     ..   |.||  ..  .  . .| |  |  .    || |. | .  .||.    || .  |  .|.| .   
arleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre

SGEYGKISVANLEIETRRDYTITVLTVhnSTTNESRRITHFQFTSWPDFGTPRSA--LAMLEFREEVRQY-----QSTSVKEMGDEWTGHPGGPPIVVHC
  ..|.. |   |   |  .    | .  |  ||. |. |...  | .. .|.    ||. .   ||        .|. .. .   .   |     .. .
elkfGildverkefvkrniletrllel..skGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqs

SAGIGRTGTFCTLDISLaRLEDVAT---IDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQRS
. |  |.|.|  .|. . || |        | . .  .. .| .|. .  |. | | ....| .| 
arGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 445-578 8.2e-17 55.9 In-house 203-345 (350) alignment 
Range on Protein: 445-578
Range on HMM: 203-345/350.0
TITVLTVHNSTTNEsrrITHFQFTSWPDF---GTPRSALAMLEFREEVRQYQstsvkeMGDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLARLED--
..| .|.  |   .   . ..|.  |.|      |.| | .|| .... .        .  ..     ..||.||||||.|||||..|||  |  .|.  
sltaitlaasdPyv...vyqlqvknWkDlslllnPesilqalevkndliddl......faeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeile

-----VATIDV--------CNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQ
        .||          .|  .| ||   .|. ||. |.| ||  | .
nltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 342-579 1.3e-16 55.6 In-house 31-261 (290) alignment 
Range on Protein: 342-579
Range on HMM: 31-261/290.0
DHSRVFLPILNGDPYSDYLNANYMDgYKQKNAFIATQGALPKT-------FSDFWLMIWESQCRTIVMTTRTVERGRL----KCGQYWPLEEGTSGEYGK
 ..|| |        .||. ||..  . .  ..|.||  . |.         .|| |. . . . .||.    |. .      | .| | ..|..  .. 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

ISVANLEIETRRDYTITVLTVHNSTTNEsRRITHFQFTSWPDFGTPRSALAMLEFREEVRQYQStsvkemgdewtghpggpPIVVHCSAGIGRTGTFCTL
..|   . |.  |  .  |.|.    .|   .|| .. .| .  .... . .|.  . |.....                 |..|||  || |  .. ..
ltvkCkskekeddvetRelvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvkaskt.................pvivHcvdGiSrsAalaai

DISLARLE-DVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVEYAQR
...   .      . . . .  .| |||  |... .. |   ..| .|..
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 365-567 1.9e-13 44.6 In-house 83-278 (302) alignment 
Range on Protein: 365-567
Range on HMM: 83-278/302.0
MDGYKQKNAfIATQGALPK--TFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETR-------RDYTITVLTVHNST
||| ..|.  .. .   ||  |   .| .| . .   .|  .  || .  || .|.  . |   ..|. .|  ....|        .....  . ..|. 
mdGtekkek.vskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknek

TNESRR--ITHFQFTSWPDFGTPRSALAMLEFREEVRQYQSTsvkemgdewtghpggppIVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMR
...  .  .  ..|..||| |.|. | . |.       |. .                 ..||||||.|||||. ..   .       . |. . |  .|
kkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.................vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvr

AQRAYSIQTPDQYE
. |  ..|. .|  
qcryGavqdeqqli
CRAL_TRIO_2 Divergent CRAL/TRIO domain 6-89 5.9e-13 37.6 Pfam-A 62-148 (149) alignment 
Range on Protein: 6-89
Range on HMM: 62-148/149.0
FTNFDLTMSKKLLGMLRDGYPARLKRIYVVTPPLWFKAMY-KILTPMLKEKM-KERVT-LVSAERLCRYLPATSLPKDLGGTAEINH
 ....|   |||. .|.  |. .||..|.| |  ..| ..  .|.... .|  |  |. . | . | .|.  |.|.|.|.|... ..
enkpslswlkklyktlprrykknlkkvylvhpstflksilstllslfvskkflkkkviyisslseLseyiditqlkkslpgvysyde
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 513-575 3.8e-12 40.4 In-house 1-63 (69) alignment 
Range on Protein: 513-575
Range on HMM: 1-63/69.0
IVVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVE
.|||||.| |||||| .. . .||.     .|. | |. ||  |   .    .| | . ||||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 514-575 5.5e-12 39.9 In-house 1-62 (69) alignment 
Range on Protein: 514-575
Range on HMM: 1-62/69.0
VVHCSAGIGRTGTFCTLDISLARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALVE
|||||.| |||||| .. . .||.     .|. | |. ||  |   .   ..| | . ||||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 456-576 2e-11 37.8 In-house 214-343 (349) alignment 
Range on Protein: 456-576
Range on HMM: 214-343/349.0
TNESRRITHFQFTSWPDFGT---PRSALAMLEFREEVRQYQSTsvkemgDEWTGHPGGPPIVVHCSAGIGRTGTFCTLDISLA----RLEDVATIDVCN-
...   .  .|.  |.| ..   | | |  || ....   . .      . .      ....|||||| ||||...|||. |.      ..   |.. . 
vekPyellqlqvknwldlslllnPisilqalevkndliddlfa......rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqal

-------TVRLMRAQRAYSIQTPDQYEFCYFALVEY
       .|  .| ||   .|   |. ..| ||..|
lkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 306-379 3.2e-11 37.3 In-house 26-95 (95) alignment 
Range on Protein: 306-379
Range on HMM: 26-95/95.0
YKEYAAIRAEPPAgTFYASKHRLNVHKNRYADVLCYDHSRVFLpilNGDPYSDYLNANYMDGYKQKNAFIATQG
 .|. .|     | .. .     |. |||. ... || .|| |        |||.|| ..||| .||..||.||
dnefksismtsga.pytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 331-419 3.7e-11 36.9 In-house 50-154 (349) alignment 
Range on Protein: 331-419
Range on HMM: 50-154/349.0
HKNRYADVLCYDHSRVFLPILN--------------GDPYSDYLNANYMDG--YKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKC
 |||| |.| |.|||| |.                 .    ||.||||.    .. .. .||||  || |  ||. .|   . . ..  .   | .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

GQYWP
 .|| 
diywq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 328-476 1.2e-10 35.5 In-house 95-237 (244) alignment 
Range on Protein: 328-476
Range on HMM: 95-237/244.0
LNVHKNRYADVLCYDHSRVflPILNGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTrTVERGrlkcGQYWPLEEGTSGE
 | .||| .  | .| .||  |. .|     |.|| ..    .   .| ||  |  |  ||| |. |     .|.   .||       .|||  |     
nnswknregaglpfdfnrv..plskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg.sveee....deywpdseplewy

YGKISVANLEIETRRDYTITVLTVHnSTTNESR-RITHFQFTSWPDFGT-P
   |.|.  . .  ..   . | .  |  |||   .| || . ||  || |
eeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdgttp
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 325-403 1e-09 32.4 In-house 30-107 (332) alignment 
Range on Protein: 325-403
Range on HMM: 30-107/332.0
KHRLNVHKNRYADVLCYDHSRVFLPILNGdpYSDYLNANYMDGYKQKNAFIATQGALP-KTFSDFWLMIWESQCRTIVMT
|   |.  ||   . |.||||| |   .|    |. ||...||| .|.|.| .|  .  .|   || |. | .   |.. 
kflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 292-367 1.1e-09 32.1 In-house 10-85 (440) alignment 
Range on Protein: 292-367
Range on HMM: 10-85/440.0
ALVSYVLNMRQSGIY-KEYAAIRAEPPAGTFYASKHRlNVHKNRYADVLCYDHSRVFLPILNGDPYSDYLNANYMDG
 .. || | |.|  .  |.. . .     .  ||    |  |||| ..|.||||||.|  ..| | |||.|| |..|
dfadyvqnnrrsrafedewsllpsglsqpsdiaslpn.nkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 370-495 1.5e-09 32.3 In-house 33-151 (255) alignment 
Range on Protein: 370-495
Range on HMM: 33-151/255.0
QKNAFIAtqgalpkTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETRRDYTITVLTVHNSTTNESRRITHFQFTS
.|| ..        |   |. .|  ..  ..|| .   | |. || .|.|||      . ...|.  .  .       ..| . .   . . ..|.... 
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDFGTPRSALAMLEFREEVRQYQST
|..  .|. |  .|.    ||. .| 
WieknaPelareilnilkvvrdsksv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 295-401 2.2e-08 28.0 In-house 3-114 (347) alignment 
Range on Protein: 295-401
Range on HMM: 3-114/347.0
SYVLNMRQSGIYKEYAAIRAEPPAGTFYASKHRLNVHKNRYADVLCYDHSRVFLPIL-----NGDPYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFW
 |.|..... .   . .  |.     | ...   .. |||  ||   | .|| |        . |.   |.|| ..   . .. .| ||  ||.|  |||
kylldikeaslstyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfw

LMIWESQCRTIV
 |.   .   .|
kmvsvtkvtqvv
subfamily_hpo-7_pd Subfamily hpo-7 370-491 4.4e-08 27.4 In-house 36-153 (263) alignment 
Range on Protein: 370-491
Range on HMM: 36-153/263.0
QKNAFIAtqgaLPKTFSDFWLMIWESQCRTIVMTTRTVERGRLKCGQYWPLEEGTSGEYGKISVANLEIETrrDYTITVLTVHN--STTNESRRITHFQF
.|| ..     | .|   |. .|  ..  ..|| .   | |. || .|.|||      . ...|.  ..    |  .  | . .  .   . . ..|...
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysy

TSWPDFGTPRSALAMLEFREEVRQ
. |..   |. |  .|.  . .|.
kgWiekndpelareilnilkvarn
0038934 (Phosphotyrosine protein) phosphatases II 499-570 1.5e-07 26.7 In-house 104-170 (194) alignment 
Range on Protein: 499-570
Range on HMM: 104-170/194.0
EMGDEWTGHPGGPPIVVHCSAGIGRTGTFCTldislARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFCY
.. ||..    |  ..||| ||.|||||..      | |  .  ...   ..|.|  |  .|...|..|  .
dlvdeflnedpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 341-475 4.4e-07 24.3 In-house 5-126 (130) alignment 
Range on Protein: 341-475
Range on HMM: 5-126/130.0
YDHSRVFlpilngdpYSDYLNANYMDGYKQKNAFIATQGALPKTFSDFWLMIWESQCRTIVMTTrTVERGrlkcGQYWPLEEGTSGEYGKISVANLEIET
.. ||.           .|.||...    . . .. || .| .|  ||| |. |     .|.   .||       .|||  |       .| |.  . . 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpdsePlewyeediivtltdrde

RRDYTITVLTVHNSTTNESRRITHFQFTSWPDFGT
 .    . | ...   .  . .| || . ||  ||
fknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_egg_pd Subfamily egg 512-574 2e-06 21.7 In-house 203-267 (307) alignment 
Range on Protein: 512-574
Range on HMM: 203-267/307.0
PIVVHCSAGIGRTGTFCTLDISLARLE--DVATIDVCNTVRLMRAQRAYSIQTPDQYEFCYFALV
|.||..  |. ...|. ...|.|  |    .    | ..| ..| .| .|.... .| | |  ..
pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_PTPDC1_pd Subfamily PTPDC1 513-569 2.1e-06 22.3 In-house 117-168 (182) alignment 
Range on Protein: 513-569
Range on HMM: 117-168/182.0
IVVHCSAGIGRTGTFCTldislARLEDVATIDVCNTVRLMRAQRAYSIQTPDQYEFC
. ||| || ||||   .     . |  .  ..  ....|.|..|. |||| .| |..
vavhChaGlGrtGvlia.....cylvyakrltaekaiklvrskrpksiqtreqvelv