Gene PTPRD in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP073_AA protein Get Run
SpurP073_AA_1201-1476 phosphatase_domain Get Run
SpurP073_AA_1488-1767 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1196-1526 3.8e-172 568.8 In-house 2-333 (564) alignment 
Range on Protein: 1196-1526
Range on HMM: 2-333/564.0
HPPIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLL
..||||....||...|| |. . |..||..||.||||||...| ..||.||||||..|||||||.||..|| .|||| ||...|||||..||||||||| 
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLA
||..|||||||||...||||.|||||...|||..|||....|.|| ..||| ...|||.|..|.| | |..|.|.|||.||.||.||||||||.|||.|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLT
.|..|...|.||||||||||||||||||..||||.||||||.|||||||..|..||.|||.||||||||||||||..||.|.|.|||...||. |.|||.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

ALEPGETITGMENEFKRLA-SQKAQPSRFVSA
  |.....||.|.||.||| ... ....| .|
eveedtemtgleleFqrLatakeieleefava
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1199-1513 1.6e-131 433.1 In-house 2-318 (318) alignment 
Range on Protein: 1199-1513
Range on HMM: 2-318/318.0
IPVSQFQEHIERLKGNDAMLFSQEYESIE-PGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
|.|.....|..||. .  .|.|.||| ..   ...|. .|. ..|| ||||||..||||.|| |...|| .|||| |||| ||||...||||.|.|| ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

MADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFI
. ||||||||| . .|||.|..||| ..|...||| .. ..|| ..|.| ...||..|..|.| . .. . |.|.|.|...|.|||.||||...|.|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

SRVKSCN-PPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLTA
 .|.. . ...|||||||||||||||| .|..|..|||||.|..||... |. || ||| |||||.||.||...| ||.||| |||.|..|  .|..|. 
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

LEPGETITGMENEFKRL
 .|    | |. ||.||
qdpesgttemdaefqrl
subfamily_PTPRD_pd Subfamily PTPRD 1518-1771 3.4e-126 417.1 In-house 35-286 (564) alignment 
Range on Protein: 1518-1771
Range on HMM: 35-286/564.0
AQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCH
 | ... .|| |||| |||. || .|. .||.|....|.|||||||||.|||||.|.||||||||||||.||||||.|||||..||||.||.|.|..|||
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

QYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPISVHCSAGVGRTGVFI
.|||......|....|....|... .|..|.||...... .||..|||.||.||..|||.|.....|.| .|....|   ..||| |||||||||||.||
kYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfi

TLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFDH
.....|||...|. ||..|.||.||.||.||||||.||.|...| ||.| ... 
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1198-1511 2.5e-121 399.6 In-house 4-319 (319) alignment 
Range on Protein: 1198-1511
Range on HMM: 4-319/319.0
PIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
.|.| ...|....|. .  .|. .|.. .. ....|.|... | ||.|||| |..|||..||.||...| .|||| ||.. |||......||||.|| .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

MADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALV-KNRSMEKREVKQFQFTAWPDHGVPEHATSVLAF
. ||||||||... ..||.||| |. .||. .|||. . |.|| . |||..  ||. | .| . |  |.  .| ||||.||.|.||||.|||.|||.|..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

ISRVK-SCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLT
. |.. | . ...|||||||||||||||..||.| ||||.|.| ..|..  |  ||.||| |||..|||.||.||| ||| .| ||.. ..|   ...|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

ALEPGETITGMENEFK
  ...   ||.|.||.
ekvadtgetglerefq
subfamily_PTPRG_pd Subfamily PTPRG 1199-1487 2.6e-116 384.1 In-house 1-299 (563) alignment 
Range on Protein: 1199-1487
Range on HMM: 1-299/563.0
IPVSQFQEHIERLKGNDAMLFSQEYESIE---PGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGS-DYTNANYCDGYRKQNAYIATQGPL
.||..|..|.  |. .. . ||.|.|...     .... .||. . || |||| |..|||.||| |||. |  .. || |||| |||.|..|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

LETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVK----NRSM--EKREVKQFQFTAWPDHGVPE
 .|. |||||.|||....|||.|.|.||.| |||.|||. . |.|| .|||| ..  ||.||||.. . .    . .   ....|.|...| ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNL
|.. || |. . .  |. .|||||||||||||||| |||.|..|..|..|..|...| .  .|||||..|||||||||.|.|| ||.||. ||. | ..
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1504-1772 1.9e-114 377.0 In-house 20-286 (318) alignment 
Range on Protein: 1504-1772
Range on HMM: 20-286/318.0
TGMENEFKRLASQKAQPSRFVSaNIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
. ...|..||. ........ | . |.||.|||  || .|.  || ||.. |.||||||||..|||||...||||.|.||.|| ||||||.|||||..||
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqEGPIS
||....| |..|.|.||| . |  |.  ||. ..| .. .|.|||||||     .||..||...|.||..|||.|| ...|...||.|.... | .||| 
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpiv

VHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFDHY
||||||||||||||.....|||.. |..||.|||||.||.||..||||||||.|.|.. ||.| |.| .
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_PTPRA_pd Subfamily PTPRA 1193-1510 2.5e-111 366.7 In-house 8-330 (330) alignment 
Range on Protein: 1193-1510
Range on HMM: 8-330/330.0
MMSHPPIPVSQFQEHIERLKGNDAMLFSQEYESIEP-GQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQ
   ..|.|| ...| |.. . .|. || .|....     | | . .. | || |||. |.. ||.||||||..|| . ||| || . |||.... .||.|
nkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaq

GPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVK----NRSMEKREVKQFQFTAWPDHGVP
||. ||. |||||.|||.. ||||.|.|.||.. || ||||.     || |.|.. |.|.|  |||| | . .     |  ..| |.|| ||.||| |||
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

EHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNL
 ..  .| .. .||..|.  ||||||||||||||||..||.|..|||.| |. ||... |  ||.||  ||||.||| ||...| |    | ||...  |
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssl

YGHIQKLTALEPGETITGMENEF
  |.||| .  .| . .|.|.||
ekhlqklynkitgtdkigleeef
subfamily_PTPRK_pd Subfamily PTPRK 1196-1511 7.4e-107 351.8 In-house 1-313 (314) alignment 
Range on Protein: 1196-1511
Range on HMM: 1-313/314.0
HPPIPVSQFQEHIERLKGNDAMLFSQEYESIEPGqqftWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLL
|| | |    ..|  || ...  | .||||.  |    || .. . |. |||. ...|||.|||.| ...| | ||| ||.. |.|.. .|.|.||||| 
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEkYGFIQVTLLDTTELATYTVRSFALVK--NRSMEKREVKQFQFTAWPDHGVPEHATSV
||..||||.|..... .|||.|.| |  |||| .|||   .  || |.|.|..|. || . || |.. |      |.|||.||||..||||.|| .||..
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQK
|... |||. ....||.|||||||| ||||..|.||..|. |..|..||..  |  ||...  ||.|||||.||.... ||.  | | . . ..     .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LTALEPGETITGMENEFK
 . |.|    . ...||.
sirldpqtnssqlkeefq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1203-1482 3.6e-106 349.8 In-house 13-297 (298) alignment 
Range on Protein: 1203-1482
Range on HMM: 13-297/298.0
QFQEHIERLKGNDAMLFSQEYESIEPGQQ----FTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETM
..|.  .  | .. . ...|.. .. ...    .... .. ..|| |||||..||.|.|||.|. ...   ||| || . ..|...||.||||.|| ||.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

ADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFIS
.||||||.|.  .||||.|.||| ...|. .|||.. .|.|| |.|.|| . | | ..|| ... |... ..|||.|..|| |||.||||.|||||....
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

RVKScNPPDAG--PIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEV
.|.  .. .||  |..|.|||||||.|..|.|||.|||.|.|..||..  |  ||..|  .|||||||.||.||  ||..|. .|.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0051299 (Phosphotyrosine protein) phosphatases II 1196-1474 4.6e-106 349.7 In-house 2-285 (288) alignment 
Range on Protein: 1196-1474
Range on HMM: 2-285/288.0
HPPIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQ-QFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPL
. .|.|... .....|. |. ... .|.| . . . ..|. ...|. |..|||| ....||||||.||...| .|||| ||.| |||......|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

LETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKN----RSMEKREVKQFQFTAWPDHGVPEHA
 .|..|||||||||....|||.|||.|..|.||.||||... ..|| |.||||....|..|||| . ....     . |.|.|..|..|.|||||||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
...|.|. .|....... ||.||||||||||||..|..| .||....|..||... |  || ||..||||.|||.|..|||.|.
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_PTPRB_pd Subfamily PTPRB 1197-1478 3e-105 346.5 In-house 5-288 (293) alignment 
Range on Protein: 1197-1478
Range on HMM: 5-288/293.0
PPIPVSQFQEHIERLKGNDAMLFSQEYESIEP-GQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLL
 || ...|.||....| .. . ||.|||...  |.. . . ..|..|. |||| |...|||||| |..... .|||| |||| .||. .. .||||||| 
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTR-DQEKYGFIQVTLLDTTELATYTVRSFALVKnrSMEKREVKQFQFTAWPDHGVPEHATSVL
||. ||||||||.....|||.|.| |. .|||..|||.  ..  || |.|||. ..||  ...|.... |  ..|.|.|.|..||.||||||||.....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFISRVKSCN--PPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASG
.|. .|..      ...||||||||||||||..| .| .|..|..| .|||.| |. || .||..||||.||||||... . . ..
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
0040438 (Phosphotyrosine protein) phosphatases II 1203-1513 3.2e-105 347.1 In-house 4-314 (317) alignment 
Range on Protein: 1203-1513
Range on HMM: 4-314/317.0
QFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFW
.. .....|. .|......|.| .   .  |.....|. ||.|||| ... ||||||.|||..| ..||| ||.| ||.......||||||| .|..|||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKS
||||||....|||.|.|||..|.||.||||...  .|| ..||||...||| .|.| . ...... |.|.|..|..|.|||||||.. ...|.|...|..
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

CNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLTALEPGET
..... ||..|||||||||||..|... |||....|..||..  |  ||.||...|||.|||.|...||.| .  . | . | .|. ...||..  ... 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd

ITGMENEFKRL
 ...| |.|.|
vklkekelkll
0050432 (Phosphotyrosine protein) phosphatases II 1187-1477 3.8e-103 340.3 In-house 14-301 (308) alignment 
Range on Protein: 1187-1477
Range on HMM: 14-301/308.0
SENGTAMMSHPPIPVSQFQEHIERlkGNDAMLFSQEYESIEPGQQ-FTWDHSNLETNKPKNRYANVIAYDHSRVILspmeGlPGSDYTNANYCDGY--RK
  . . ..|. ...| .. ...|.   .|  |...|.| .   .  .......|. ||.|||| ....||||||.|    . .|||| ||.| |||  ..
frdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgysskl

QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTR---DQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTA
....||||||| .|..|||||||||....|||.|||.|..|.||.||||.    . ..|| ..||||....|..|||| . |..... | |.|..|..|.
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytn

WPDHGVPEHATSVLAFISRVKSCNPPdaGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVAS
|||||||......|.|. .|....|.  |||||||||||||||..|..| .||....|..||... |  || ||..||||.|||.|...||.| . .
WpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 1479-1766 1.2e-102 338.5 In-house 2-286 (288) alignment 
Range on Protein: 1479-1766
Range on HMM: 2-286/288.0
TTEVHARNLYGHIQKLTalepGETITGMENEFKRLASQKAQpSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIA
.||.....|. ...||.       .||...||..| |....   . .|. |.|. |||  .| ||. .||.|... |||||||||||.||||.. ...||
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

TQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQG
||||| .|.||||||.||||...|||| || |.|||||.|||| . |  |  ..|  .||. .. |..|...||.      ||.|||...|..|.||..|
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VPKSGEGFIDFIGQVHKTKEqfGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
|| | | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....|| ||....||.||.||| ||||..||.|.|.|.||||
vpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1495-1769 3.2e-102 337.2 In-house 33-302 (308) alignment 
Range on Protein: 1495-1769
Range on HMM: 33-302/308.0
TALEPGETITGMENEFKRLASQKAqPSRFVSANIPANKFKNRLLNIQPYEGNRVCLqpirGvEGSDYINASHIDGY--RQRNAYIATQGPLAETTEDFWR
 .||.   ....| ||..| |.|  .  . .|. |.|| |||  .| ||. .||.|    . |||||||||..|||  ......||||||| .|.|||||
kllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MLWEQNSTIIVMLSKLREMGREKCHQYWPAE---RSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQV
|.||||...|||| || |.|||||.|||| |    | .| .|.|  .||.... |..|....|. .||.|||...|..|.||..||| | | ..||. .|
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

HKTKeqfgQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSF
.|.     ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||..||.|.|.|.|||| ..
rksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1504-1770 3.9e-101 333.3 In-house 23-287 (319) alignment 
Range on Protein: 1504-1770
Range on HMM: 23-287/319.0
TGMENEFKRLASQKAQpsRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
|..|.||| |   ...   | ||. . || |||  || .|.  || |... |||||||||||.||||..|...||||.||..|.||||||.||..| |.|
tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQ-SRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgQEGPI
||.|| | .. |...||| |   .|  ..|.. .| .. .|| |..|.  . .   .|.. .||.|.||...||... . .|......|..|.  |.|||
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.qsgPi

SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFD
 ||||||||||| ||.|...|||.. ||..|.|.||..|||||. |||...||.|.|.| ||.. ..|
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1478-1772 3.9e-98 323.4 In-house 1-296 (298) alignment 
Range on Protein: 1478-1772
Range on HMM: 1-296/298.0
GTTEVHARNLYGHIQKLTALEPGETITGMENEFKRLASQKA--QPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNA
| ||..|..|  ..|||.| .. ...||...||.|| | .   .      |. |.|| |||  .| ...  || |. . . | |||||||....|..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGV
.||||.|| ||.||||||..|.... |||| .|.|... |.|.||| |....|  . |. .|.... ..| |..||....  ..|..||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGFIDFIGQVHKTKEQFGQeGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFDHY
|.  .  .|.. .|.....| |.  |. |.|||||||.| || .. ||||.. |  ||.||.||.||..||..||||.|| |.|.| ||.| ||. .
penatsvldllrkvrasqqqagn.kpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0046845 (Phosphotyrosine protein) phosphatases II 1505-1769 9.6e-98 322.3 In-house 1-277 (284) alignment 
Range on Protein: 1505-1769
Range on HMM: 1-277/284.0
GMENEFKRLASQKAQPS-RFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGV-EGSDYINASHIDGY-----RQRNAYIATQGPLAETTEDFWRMLWEQ
|.| ||..| |..  ..  .  |. |.|. |||  .| ||. .||.|... |  |.|||||||..|||     ......||||||| .|.||||||.|||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSTIIVMLSKLREMGREKCHQYWPAER-SARYQYFVVDPMSEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
|...|||| .| |.|||||.|||| |  . .|  | |  .||.... |..|....|.   .|.|||...|..|.||..||| | | ...|. .|..  |.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEG---IVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSF
....||| |||||||||||.||.| ..||....||    ||....||.||.||| ||||..||.|.|.|.|||| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1198-1495 1.3e-97 321.6 In-house 3-303 (305) alignment 
Range on Protein: 1198-1495
Range on HMM: 3-303/305.0
PIPVSQFQEHIERLKGNDAMLFSQEYESIEPGqQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
.| .......|.  . ...  . ..|.|.    . . |  . |.|| |||..... .|..|.||.. | |. ||| ||.| |||.....||..|||| .|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQE--KYGFIQVTLLDTTELATYTVRSFALVK-NRSMEKREVKQFQFTAWPDHGVPEHATSVL
.|||||...| ...||||.||| | .. || ||||.. .|  ..| ..|.| .... . |. | . . . . . |.| | |.|.| |||||||. |||.|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

AFISRVKSCNPPDAG-PIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQK
 .| ||.     | | |..|||||||||||..|..| .|||.|.|..||... .  || .| .|||| .|| |.|.|| | . .| |..   ||  ...|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LT
| 
lk
0043336 (Phosphotyrosine protein) phosphatases II 1198-1473 1.4e-97 321.8 In-house 1-275 (278) alignment 
Range on Protein: 1198-1473
Range on HMM: 1-275/278.0
PIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
||.|.........|. |.  |...|.|..   . .|.....|. ||.|||| ....||||||.||...| ..||| ||.| |||......||||||| ||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

MADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPtRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFI
..||||||||....||||.|.|.|..||||.|||| .. ..|| ..||||....|..|||| . ...... |.|.| ......||||||||. ...| |.
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

SRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
 .|....... ||..|||||||||||..|... .||....|..||..  |  || ||  .|||..||.|..|||.|
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 1504-1766 5.5e-97 320.1 In-house 18-276 (317) alignment 
Range on Protein: 1504-1766
Range on HMM: 18-276/317.0
TGMENEFKRLASQKAQpsRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
|....||..| |.|     .  |. |.|| |||  .| ||. .||.|.|. |...|||||||..||.......||||||| .|.||||||.|||..|.||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPIS
|| .| |.|||||.|||| . .  |  |.|  .||. .. ..||...|.| .|..|||...|..|.||..|||.| . ..||. .|..  |  ...||. 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
|||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||.|.| |.||||
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0046845 (Phosphotyrosine protein) phosphatases II 1221-1478 1.2e-96 318.7 In-house 4-277 (284) alignment 
Range on Protein: 1221-1478
Range on HMM: 4-277/284.0
QEYESIEPGQQF---TWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGL-PGSDYTNANYCDGY-----RKQNAYIATQGPLLETMADFWRMVWEQRTN
.|.| .   . .   ......|. |. |||| ....||||||.|....|  ..||| ||.| |||     ......||||||| .|..|||||||||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TIVMMTKLEERNRVKCDQYWPTRD-QEKYGFIQVTLLDTTELATYTVRSFALVKNR-SMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNP--PD
.|||.|.|.|..|.||.||||. .   .|| ..||||....  .|||| . |...  . | |.|..|..|.|||||||......|.|.  |.....  |.
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

AGPIVVHCSAGVGRTGAYIVIDSMLERIKHEK---TVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASG
 |||||||||||||||..|..| .||....|.   .||... |  || ||..||||.|||.|..|||.|.. ..
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0036941 (Phosphotyrosine protein) phosphatases II 1212-1486 3.5e-96 317.3 In-house 8-288 (297) alignment 
Range on Protein: 1212-1486
Range on HMM: 8-288/297.0
KGNDAMLFSQEYESIEPGQ-QFTWDHSNLETNKPKNRYANVIAYDHSRVILspmEGlPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRT
| .. .|...|.|.. | . ........|. |..|||| ....|||.||.|   .. .|||| ||.| |||. ....||||||| .|..|||||||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

NTIVMMTKLEERNRVKCDQYWPTR--DQEKYGFIQVTLLDTTE--LATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPP
..|||.|.|.|..|.||.||||.   .  .|| ..||||....  |..||.| . ...... |.|.|..|..| ||||||||...|.|.|| .|..... 
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--DAGPIVVHCSAGVGRTGAYIVIDSMLERIK---HEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARN
  . ||..|||||||||.|..|..| ||....   .|..|||.  |  || ||. .|||.|||.|..|||.| . ...| . ...
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 1502-1766 7.3e-96 316.1 In-house 10-272 (273) alignment 
Range on Protein: 1502-1766
Range on HMM: 10-272/273.0
TITGMENEFKRLASQKAqPSRFVSANIPANKFKNRLLNIQPYEGNRVCLqpirGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTI
 .|... ||..| |.|  .  .  |. |.|| |||  .| ||. .||.|    | .||||||||..|||.. ...||||||| .|.||||||.||||...
gltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLSKLREMGREKCHQYWPAER---SARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
|||| .| |.|||||.|||| |    | .|  | |  .||.. . |..|....|.  .|.|||...|..|.||..||| | | ...|| .|.|. |.. .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

EGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
.||. |||||||||||.||.| ..|.....|| ||....||.||.||| ||||..||.|.|.|.||||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1241-1477 8.8e-96 314.9 In-house 8-244 (250) alignment 
Range on Protein: 1241-1477
Range on HMM: 8-244/250.0
TNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVkCDQYWPTRDQEKYG
 || |||||..||.|.|||.| . .|   ||| || . .||....|.||||||| .|. ||||||.|. ..||||.|.|.| ... . ||||.   ||||
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

FIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPP-DAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEK
 ..|.||.. | | ||.| . | |..  ..| |.|..|..||| ||||.||.||.....|.. ..  ...|..|.|||||||.||.|.||..|||.|.||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVAS
.||..  .  ||..|  .|...|||.|..|.. .|. |
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPRA_pd Subfamily PTPRA 1507-1765 1.3e-95 315.1 In-house 35-294 (330) alignment 
Range on Protein: 1507-1765
Range on HMM: 35-294/330.0
ENEFKRLASQKAQpSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLS
 .||. | . . | . .  |.   || |||..|| ||. .|| |....||| |||||||.||||.... .||.|||..|| ||||||.|||.|. ||||.
reefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

KLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQegPI
.|.|  .|||.|||| | .  |    |    |  . .| .|.| |..     |. .|| .||| || ||. |||  . | .... .|.|...| ..  ||
elkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pi

SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
 ||||||||||| ||.|. ||||.. |..||.|..|| ||.||| ||||. ||.|.|.. |||
vvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1206-1475 6e-95 312.6 In-house 10-279 (288) alignment 
Range on Protein: 1206-1475
Range on HMM: 10-279/288.0
EHIERLKGNDAMLFSQEYESI-EPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRM
... . . ..   ||.||.|. . ... . . ..|  |..|||| |...||. || |  .|  .|.|| ||.| ||..|...|||||||| .|. |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ-EKYGFIQVTLLDTTELATYTVRSFALVknRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSC
|.|..|.||||.|.| |... ||..|||. |. ..|| ..|||... ||  ...|.. |.  ......|..|.|..||||||||| .. .|.... ||  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkva

NPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
|. |.|||.||||||||||| .|..| .......|...|. | |. || ||. .|||..||.||.|.| . .
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0039614 (Phosphotyrosine protein) phosphatases II 1192-1476 8.4e-95 312.9 In-house 7-290 (297) alignment 
Range on Protein: 1192-1476
Range on HMM: 7-290/297.0
AMMSHPPIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQfTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGL-PGSDYTNANYCDGYRK-QNAYIA
|.....|||.| .  .. ..| |. .|. .|.|..   .   . ...|. ||.|||| ....||||||.|.|..|  ..||| ||.| |||.. ....||
allesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

TQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRvKCDQYWPTRDQeKYGFIQVTLLDTTELATYTVRSFALVKnrSMEKREVKQFQFTAWPDHGVPEH
||||| ||..|||||||||....|||.|||.|..| ||.||||.. . .|| ..||||....|. |||| . ...  . | |.|..||.| |||||||..
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvpps

ATSVLAFISRVKSCNP--PDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVA
....| |.  |....   |. ||..|||||||||||..|... |||....|..||..  |  || ||...|||..||.|...||.| . 
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0036941 (Phosphotyrosine protein) phosphatases II 1502-1769 9e-95 312.6 In-house 11-280 (297) alignment 
Range on Protein: 1502-1769
Range on HMM: 11-280/297.0
TITGMENEFKRLASQKAqPSRFVSANIPANKFKNRLLNIQPYEGNRVCLqpirGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTI
 ..... ||..| . .. .  .  |. |.|. |||  .| ||. .||.|    . |||||||||..|||.. ...||||||| .|.||||||.||||.|.
flalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMLSKLREMGREKCHQYWPAE--RSARYQYFVVDPMSEYN--MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG
||||..| |.|||||.|||| |   |  |  |.|  .|..    . |.||...||| ..|.|||...|..|.||. ||| | . ..||| .|.|  ... 
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

QEGPISVHCSAGVGRTGVFITLSVVLERMR---YEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSF
..||. |||||||||.|.||.. ..|....   .|| ||....||.||.||| .|||..||.|.|.| ||.| ..
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0039614 (Phosphotyrosine protein) phosphatases II 1496-1769 1.9e-94 311.7 In-house 24-292 (297) alignment 
Range on Protein: 1496-1769
Range on HMM: 24-292/297.0
ALEPGETITGMENEFKRLASQKAQpsrFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGV-EGSDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRM
 ||.   .|....||..| |.|     .. |. |.|| |||  .| ||. .||.|.|..|| ..|||||||..|||..  ...||||||| ||.||||||
llekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LWEQNSTIIVMLSKLREMGReKCHQYWPAERSaRYQYFVVDPMSEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK
.|||..|.|||| || |.|| ||.|||| | . .|  |.|  ....  . |..|...||.  .|.|||...||.|.||. ||| | | ...|. .|..  
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

EQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSF
.. ...||. |||||||||||.||..  .||....|| ||....||.|| ||| .|||..||.|.|.|.||.|  .
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 1195-1474 4.8e-94 310.8 In-house 5-303 (307) alignment 
Range on Protein: 1195-1474
Range on HMM: 5-303/307.0
SHPPIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQF---TWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGL-PGSDYTNANYC--------DGYR
 ...|.. ..  .. .|. .. ... .|.|.. . . |   ......|. ||.|||| ....|||.||.||...|  ..||| ||.|         |||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

KQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQE-KYGFIQVTLLDTTELATYTVRSFALVKN-RSMEKREVKQFQFTA
.....||||||| ||..|||||.|||....|||.|.|.|..|.||.||||. ..|  || ..||||....|. |||| . .  .  . | |.|..|..|.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHGVPEHATSVLAFISRVKSCNPP--DAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKT---VDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
|||||||..  ..|.|| .|....    . ||..|||||||||||..|... ||.....|.|   ||..  |  ||.||  .||..|||.|..|||.| 
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 1490-1766 7.9e-94 310.1 In-house 13-304 (307) alignment 
Range on Protein: 1490-1766
Range on HMM: 13-304/307.0
HIQKLTALEPGETITGMENEFKRLASQKAQ-PSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGV-EGSDYINASHI--------DGYRQRNAYIAT
.. .| .|.. . .||.. ||..| |.. . .  . .|. |.|| |||  .| ||. .||.|... |  |.|||||||..        |||.. ...|||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSA-RYQYFVVDPMSEYNMPQYILREFKVTDA-RDGQSRTIRQFQFTDWPEQGVPK
|||| || ||||||||||..|.||||..| |.|||||.|||| |..   |  |.|  .||. .. |..| ..|||   .|.|||...|..|.||..|||.
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SGEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGI---VDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||...||.|.|.|.||.|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 1212-1474 1.2e-93 308.8 In-house 7-271 (273) alignment 
Range on Protein: 1212-1474
Range on HMM: 7-271/273.0
KGNDAMLFSQEYESIEPGQ-QFTWDHSNLETNKPKNRYANVIAYDHSRVILspmeGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRT
| ..  |. .|.| . . . ..|. ...|. || |||| ....||||||.|    | .|||| ||.| |||......||||||| .|..|||||||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

NTIVMMTKLEERNRVKCDQYWPTRD---QEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPP-
..|||.|.|.|..|.||.||||.      ..|| ..||||.... ..|||| . |... . |.|.|..|..| |||||||.. .|.| ||  |....   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-DAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
 . ||.||||||||||||..|..| .|.....|..||..  |  || || .||||.|||.|..|||.| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0043336 (Phosphotyrosine protein) phosphatases II 1503-1766 1.2e-93 308.9 In-house 19-277 (278) alignment 
Range on Protein: 1503-1766
Range on HMM: 19-277/278.0
ITGMENEFKRLASQKAqpSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTII
 |....||..| |.|     .  |. |.|| |||  .| ||. .||.|... |...|||||||..|||.. ...||||||| ||.||||||.||...|.|
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLSKLREMGREKCHQYWPaERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPI
||| .| |.||.||.|||| . | .|  |.|  ..|. .. |..| ..||. .||.|||........||..||| | . ..||. .|..  |   ..||.
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpv

SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 |||||||||||.||.| ..||....|| ||....||.||.||| .|||..||.|.|.|.||||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 1506-1766 1.1e-91 302.2 In-house 2-262 (263) alignment 
Range on Protein: 1506-1766
Range on HMM: 2-262/263.0
MENEFKRLASQKAQPsRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVML
...||..| ... .  .. .|....|| |||  || ||. .|| |... . ||||||||..|.|......|||||||| .| |||||| ||....|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SKLREMGREKCHQYWPAE--RSARYQYFVVDPMSEYNMP-QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqEGPI
..  | |.|||..||| |  .. ..... |  ... ... ..|||....|   . ..|...|.|...||..|||.| . ..... .|.|.|..   .|||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 |||||||||||.|.|....|.... |  ||.|..||.||.||| ||||..||.|.|.|.|||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1506-1766 1.1e-91 302.2 In-house 2-262 (263) alignment 
Range on Protein: 1506-1766
Range on HMM: 2-262/263.0
MENEFKRLASQKAQPsRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVML
...||..| ... .  .. .|....|| |||  || ||. .|| |... . ||||||||..|.|......|||||||| .| |||||| ||....|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SKLREMGREKCHQYWPAE--RSARYQYFVVDPMSEYNMP-QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqEGPI
..  | |.|||..||| |  .. ..... |  ... ... ..|||....|   . ..|...|.|...||..|||.| . ..... .|.|.|..   .|||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 |||||||||||.|.|....|.... |  ||.|..||.||.||| ||||..||.|.|.|.|||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 1197-1495 2.7e-91 300.9 In-house 2-306 (307) alignment 
Range on Protein: 1197-1495
Range on HMM: 2-306/307.0
PPIPVSQFQEHIERLKGNDAMLFSQEYESIE-PGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLL
..|.. . .| ..  |..  ... .|||..|    . .   |. . |. |||| ...|.|. ||.|....|   ||| ||..  ||.... .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNR--S---MEKREVKQFQFTAWPDHGVPEHA
.|. |||||..||  ..|||...|.| || ||..|||  |. .|| | |.| .. .   |. |.. . |.   |    ..|.| |...|.|.|  |||.|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGH
...| .|..|.. .  . .||||||||||||.| .. .||.|...| |..|||.  |  || ||| .||  |||.|.. || .    | |..  ..|  .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKLT
|..| 
ierlc
DSPc_SM00195 1219-1474 7.7e-91 299.4 In-house 2-261 (263) alignment 
Range on Protein: 1219-1474
Range on HMM: 2-261/263.0
FSQEYESIEPGQ-QFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMT
...|.|..|  . . . .... . || |||| |.. |||.||.|.. |. .|||| |||| .|..|...|||||||| .|..||||||||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERNRVKCDQYWPTR--DQEKYGFIQVTLLDTTELA-TYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVH
. ||... |||.|||    ..|..| |.|.| ....    ...| . | |.   |.|.|.|.|...|||||||....|||.... ||...    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
|||||||||....||..|.....||.|||   |. || ||  ||||.|||.||.||. |.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1219-1474 7.7e-91 299.4 In-house 2-261 (263) alignment 
Range on Protein: 1219-1474
Range on HMM: 2-261/263.0
FSQEYESIEPGQ-QFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMT
...|.|..|  . . . .... . || |||| |.. |||.||.|.. |. .|||| |||| .|..|...|||||||| .|..||||||||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERNRVKCDQYWPTR--DQEKYGFIQVTLLDTTELA-TYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVH
. ||... |||.|||    ..|..| |.|.| ....    ...| . | |.   |.|.|.|.|...|||||||....|||.... ||...    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
|||||||||....||..|.....||.|||   |. || ||  ||||.|||.||.||. |.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1195-1500 2e-90 298.0 In-house 2-304 (315) alignment 
Range on Protein: 1195-1500
Range on HMM: 2-304/315.0
SHPPIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPL
.| |||. |.  .. . | .    | |.||||  || .  | ..   || |||| |.||||.||| |  .|  |.||| |||. ||| |.. |||.|||.
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

LETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRdQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMekREVKQFQFTAWPDHGVPEHATSVL
 ... ||||.|.|.   .|||.|.| |... |...||| . .  || | ||. .      ||||... | .  .  ||| |...|.||| |||.......
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdni..revvqlhytswpdmgvpkytiplm

AFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVhARNLYGHI-QK
 .| .||  .  ..|.|||||||||||||..| .|..|.... |. .|.|  .| .|..|  |||. ||| ||..|| |..  | | . |..|| .  . 
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdlylqryds

LTALEPG
| |  | 
llapspd
0040439 (Phosphotyrosine protein) phosphatases II 1525-1766 2.1e-89 294.6 In-house 5-246 (249) alignment 
Range on Protein: 1525-1766
Range on HMM: 5-246/249.0
SANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAER
 |. |.|| |||  .| ||. .||.|....|...|||||||.||||.. ...||||||| ||.|||||||||...|.||||..| |.|||||.|||| . 
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLE
|  |  |.|  .|.. .. |..|....|.  ||.|||....|.||||..|||.| | ..||| .|.|  |. ...||. |||||||||||.||..  .||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
....|. ||....||.||.||| .||...||.|.| |.||.|
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1196-1494 1.1e-88 292.6 In-house 13-310 (319) alignment 
Range on Protein: 1196-1494
Range on HMM: 13-310/319.0
HPPIPVSQFQEHIERLKGNDAMLFSQEYESI--EPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGP
 |..|. . |  . .   .|   .  |.  .   . .  . ...||. || |||. |..|.|...| | ...|  .||| || . .||.... |||.|||
vpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGP

LLETMADFWRMVWEQRTNTIVMMTkleernRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVK-NRSMEKREVKQFQFTAWPDHGVPEHATS
| .|.||||||.||... |||..|      . || |||| . ..|..  .| .   .| | |.||.. | .  .  ..|...|| |  |||.|||.... 
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd

VLAFISRVKSCNPP--DAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGH
.. .. .|.  .    .  .|||||||||||||.|||.| .|.|.|.|| ||.|  |  || ||| .||   || ||. || |    | ..|   ..  .
lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

IQKL
...|
leel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1205-1476 1.1e-88 292.0 In-house 3-277 (281) alignment 
Range on Protein: 1205-1476
Range on HMM: 3-277/281.0
QEHIERLKGNDAMLFSQEYESIEP-GQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWR
..|...|. ||   | .|||...  |.. |   |. . |. |||| |..|||..|| ..| |    .|| |||...||.....|||||||. .....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQRTNTIVMMTKLEERNRVKCDQYWPTRD-QEKYGFIQVTLLDTTELATYTVRSFALvKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKS
|||||. ..|||.|.  | ...|| .|||  . . ||| ..|. . ..| |||  | | | ...| |.|||.|...|||||||||. .. .| | . |..
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

CNPPDA-GPIVVHCSAGVGRTGAYIVIDSMLERIKHE-KTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVA
.. ..   |.|.||||||||||.|| .| .......| ...|.   |. || .||.||||  || |.. |. .|. 
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0040439 (Phosphotyrosine protein) phosphatases II 1233-1474 1.1e-87 289.0 In-house 2-245 (249) alignment 
Range on Protein: 1233-1474
Range on HMM: 2-245/249.0
TWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWP
......|. ||.|||| ....||||||.||...||..||| ||.| |||. ....||||||| ||..|||||.||.. ..|||.|.|.|..|.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNP--PDAGPIVVHCSAGVGRTGAYIVIDS
...  .|| ..||||...... |||| . |...   |.|.|...|.| |||||||..  ..|.|| .|....   |. ||..|||||||||||..|... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
|||....|..||..  |  || ||...||..|||.|..|||.| 
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 1480-1766 2.3e-87 287.8 In-house 5-285 (293) alignment 
Range on Protein: 1480-1766
Range on HMM: 5-285/293.0
TEVHARNLYGHIQKLTAlepgETITGMENEFKRLASQKAQpSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIAT
........ .|..|..|    .. ... .|...| . . .    ..|. ..|. |||  || ||. .|| |..... .|||||||..|.||.... .|||
kpiklekfeehvkkmka....dsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAE-RSARYQYFVVDPMSEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKS
|||| ||..|||||.||..|.||||| .| | |..||..||||. ..  |    |. ..| .. ....||.|..   . ..|..||..|| ||. |||..
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPek

GEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 . ..||. .|....|.  ...|| |||||||||||.||.|  .|.... | .||.| .|  ||..|  .||||.|| | ... |..|
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1198-1512 2.8e-87 287.5 In-house 2-314 (315) alignment 
Range on Protein: 1198-1512
Range on HMM: 2-314/315.0
PIPVSQFQEHIErlKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
||||.||   ..  |   . |||.|.  .   . .    .  . | .|||| |.. .|..||.|  ..  | ||| || |  .. ...||||.||||  .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

MADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPT--RDQEKYGFIQVTLLDTTELATYTVRSFalVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLA
. ||||||..... ||||.||..| ...|| ||||    |  ..| |.|.||..   .  ..| .  |  .| |.| | ||||| |||.||.....|.| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllk

FISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLT
.|  ||. | ..  ...|||||||||||  | ||.....||....||..  |. |||.| |.|||||.| ||..|. | .    | .   ..  |.| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

ALEPGETITGMENEFKR
.   |.  . | .||..
tsvdgsgrskmtkefet
subfamily_PTPN9_pd Subfamily PTPN9 1212-1473 3.4e-87 287.2 In-house 11-288 (297) alignment 
Range on Protein: 1212-1473
Range on HMM: 11-288/297.0
KGNDAMLFSQEYESIEPG-QQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRT
| ..    |.||. |     . | ..|.| .|  ||||..|. ||..|| |. ... . ||| |||..|||....|.||||||| .|. |||||||||..
kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

NTIVMMTKLEERNRVKCDQYWP--TRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSC-----
 .|||.|...|| |.|| ||||  . .....|...|. ... |   |.||.. . . .  |.|.|  |||..|||.|||. |.|.| ... |..      
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav

--------NPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
         .|.  |||||||||.||||..| .|  |.|.... |||.   |  ||.|| ...||.||| | . |. |
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
Y_phosphatase Protein-tyrosine phosphatase 1242-1472 5.1e-87 286.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 1242-1472
Range on HMM: 1-234/235.0
NKPKNRYANVIAYDHSRVILspmEGLPG-SDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWP--TRDQEK
|| |||| ....||..|| |   .| .| ||| |||| .||......||||||| .|..|||||||......|||.|.|||..|.||.||||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFIQVTLL-DTT-ELATYTVRSFALVKNRSM-EKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERI
|| |.|.|  ... . . ||.| . | |. .  |||||||...|.||||||||...|.| .| .|.. . .. ||.|||||||||||| ....| .||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALY
..|..||..  |  ||.||. |||..|||||...|. 
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1242-1472 5.1e-87 286.5 In-house 1-234 (235) alignment 
Range on Protein: 1242-1472
Range on HMM: 1-234/235.0
NKPKNRYANVIAYDHSRVILspmEGLPG-SDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWP--TRDQEK
|| |||| ....||..|| |   .| .| ||| |||| .||......||||||| .|..|||||||......|||.|.|||..|.||.||||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFIQVTLL-DTT-ELATYTVRSFALVKNRSM-EKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERI
|| |.|.|  ... . . ||.| . | |. .  |||||||...|.||||||||...|.| .| .|.. . .. ||.|||||||||||| ....| .||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALY
..|..||..  |  ||.||. |||..|||||...|. 
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1503-1770 7.5e-87 286.3 In-house 21-287 (305) alignment 
Range on Protein: 1503-1770
Range on HMM: 21-287/305.0
ITGMENEFKRLASQkaQPSRFVSANiPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTII
 .|.|...| |...  . | .|  .  ||| |||| .|.... .|. |..   .. |||||||..|||.....||..|||| .| .||||...|   . |
dkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLSKLREMGREKCHQYWPAERSA--RYQYFVVDPMSEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQE
|||.||.| |..||.|||| . .   ... |.|   || ....|| |..|..    | .|||. |.|.||||..|||..   ....| .|.|.... ...
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

GPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFD
 |. ||||||||||||||.... |||.. |..||.|. .| ||..|. |||| |||.|.. |  |.. ..|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1233-1494 8.9e-87 286.2 In-house 16-274 (284) alignment 
Range on Protein: 1233-1494
Range on HMM: 16-274/284.0
TWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTkleernRVKCDQYWP
.  ..||. || |||. ...|.|...| | .. |  .||| || .  ||.... |||||||| .|.||||||.||... |||..|      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

TRDQEKYGFIQVTLLDTTELATYTVRSFALVK-NRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPP--DAGPIVVHCSAGVGRTGAYIVID
 . ..|..  .| .   .| . |.||.. | .  .  ..|...|| |  |||.|||.... ..... .|.  .    .  .|||||||||||||.|||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

SMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKL
 .|.|.|.|| ||.|  |  || ||| .||   || ||. || |    | ..|   ..  ....|
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0042113 (Phosphotyrosine protein) phosphatases II 1235-1473 4.3e-86 283.5 In-house 2-241 (245) alignment 
Range on Protein: 1235-1473
Range on HMM: 2-241/245.0
DHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTR
....|. ||.|||| ....|||.||.|||..| ..||| ||.| ||||  . .||||||| || .|||||.||.. .||||.|..||..||||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNP-PDAGPIVVHCSAGVGRTGAYIVIDSMLE
.  .|| ..||||... |..|||| . ...... |.||| ..... |||||||..  ..| |...|...   .. ||..|||||||||||..|... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
....|..|...  |  || ||  .|||..||.|..|||.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 1519-1767 4.3e-86 284.0 In-house 21-273 (278) alignment 
Range on Protein: 1519-1767
Range on HMM: 21-273/278.0
QPSRFVSANIPANKFKNRLLNIQPYEGNRVClqpirgvegsDYINASHIDGYrqRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQ
.||..  |. . |. |||  .|.||. .||.          ||||||.||||  ....||||||| .|..||||||||...|.|||| .| |.|||||.|
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQGVPKSG--EGFIDFIGQVHKTKE-----------QFGQEGP
||| . | .|  |.|  .||.... |.|| ..||.      |..||........ ||. ||| .     |.... ....  .           .....||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ISVHCSAGVGRTGVFITLSVVLERMryEGIVDMFQTVKMLRTQRPA-MVQTEDQYQFCYHAALEYLG
. |||||||||||... .  .||..  || ||....||.||.|||  .||...||.|.|...||.| 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1198-1520 7.8e-86 283.2 In-house 1-321 (515) alignment 
Range on Protein: 1198-1520
Range on HMM: 1-321/515.0
PIPVSQFQEHIERlkGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
|.|..||   ...   . . |||.|.  .   . .    .. | | .|||| |.. || .||.|  ..  | ||| || |  ..  ..||||.|||.  .
plplaqfPafvnk..nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

MADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPT--RDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSmeKREVKQFQFTAWPDHGVPEHATSVLA
. ||||.|..... ||.|.|||.| ...|| .|||    |  |.| |.| |. .   .  . | . ..|.     | | ||.|| |||.|||.|..|.| 
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllk

FISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLT
.|  ||. .   . |...|||||||||| .| |||.. ..|  ..||..  || .|..| |.|||.||| ||..|. | .    | .    .  |.| | 
likevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh

ALEPGETITGMENEFKRLASQKAQP
.   |.  . | .||. | |   .|
ssgdgrgrskmtkefqtlkslcpdp
subfamily_PTPRG_pd Subfamily PTPRG 1502-1768 1e-85 283.1 In-house 17-289 (563) alignment 
Range on Protein: 1502-1768
Range on HMM: 17-289/563.0
TITGMENEFKRLASQKAQP-SRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGS-DYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNS
. .|...||. | |. ..      ... | || ||| ||| .|.  || |.|. |.... |||||..||||.. .|.|||||||..|..|||||.||||.
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TIIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKV-----TDARD-GQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK
.||||...| | ||.||..|||.. | .|. . |  ..|  .  |  |....      . ..  . ...||...|.||..|||..    . |. .  ...
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

EQfgQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGS
..  . ||| |||||||||||..| |. .|.... | .|..|...|..|.||. .||||.||.| . | || . |
ka..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Ptp69D_pd Subfamily Ptp69D 1501-1766 3.6e-85 280.8 In-house 19-286 (307) alignment 
Range on Protein: 1501-1766
Range on HMM: 19-286/307.0
ETITGMENEFKRLASQKAQPSRfVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNST
.|  |...|...| ... . |  . ..   |..|||  .|.... .|| |..| | | |||||||.| ||.... .|| |.|. .| .|||||..||..|
dtdfglakeyekLeareidkst.kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

IIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARD-----GQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
.|||||.| |. |.||..||| |   .|.  .|...|| ....|| ||..|.   .      .|| . |...| |..  ||.. .| ...| ||.. ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

FgqEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
   ..|| |||||||||.|.|..|...|.... |  ||.|.||| || ||. .||  .||.|.|.| |.| 
n..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
0042113 (Phosphotyrosine protein) phosphatases II 1526-1766 4.4e-85 280.2 In-house 4-243 (245) alignment 
Range on Protein: 1526-1766
Range on HMM: 4-243/245.0
ANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERS
|. |.|| |||  .| ||. .||.|.|. | ..|||||||..||||. . .|||||||.||.|||||||||...|.||||... |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQEGPISVHCSAGVGRTGVFITLSVVLER
 .|  |.|  .||.... |..|...||. .|..||.........||..||| . | ..||.  |.|  .. ...||. |||||||||||.||..  .||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
...|. |.....||.|| ||| .|||..||.|.|.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 1491-1766 4.5e-85 280.3 In-house 3-290 (297) alignment 
Range on Protein: 1491-1766
Range on HMM: 3-290/297.0
IQKLTALEPGETITGMENEFKRLASQKAqPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDF
|..| |    . . |. .|.. . ....   .|  ....||  |||  ..  |.  || |. . . | ||||||...|||.|..|.||||||| .|..||
ieelvayvkekgkrGlskeyaeirnepv.eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMLWEQNSTIIVMLSKLREMGREKCHQYWP--AERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQ
|||.|||.  .|||  .. |.|| || ||||   | ||..  . |  ..  .. .|  | ..........||..  |||. ||. |||.|.. ..|.. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VHKTKEQFG-----------QEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
| ... ..            .. || ||||||.|||| |||| . |.|.. .| ||...|||.|||||  ..||..||.||| | ||| 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0045098 (Phosphotyrosine protein) phosphatases II 1216-1474 4.9e-85 280.5 In-house 7-271 (278) alignment 
Range on Protein: 1216-1474
Range on HMM: 7-271/278.0
AMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVIlspmeglpgsDYTNANYCDGYrkQNAYIATQGPLLETMADFWRMVWEQRTNTIVM
 .|... .. . .|.  .. ..... |..|||| ....||||||.          || ||.| |||  ....||||||| .|.||||||.||.....|||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

MTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKN----RSMEKREVKQFQFTAWPDHGVPEHA--TSVLAFISRVKSCNP----
.|.|.|..|.||.|||| .. . || ..||||....| .||.| . ..       . |.|.|...... |||||||..   .|.| .. ......     
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PDAGPIVVHCSAGVGRTGAYIVIDSMLERIkhEKTVDIYGHVTCLRAQRNY-MVQTEEQYIFIHEALYEA
         .. ||..|||||||||||...... |||..  |..||..  |. || ||.. .||..|||.|..|.|.| 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1502-1765 8.3e-85 279.9 In-house 32-291 (319) alignment 
Range on Protein: 1502-1765
Range on HMM: 32-291/319.0
TITGMENEFKRLASQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTI
 .| .| ||.|.. . .. .    ||.. || |||. || ... |.| |... |.|.|||||||...||.... |||.|||| .| .|||||.||.|.. 
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLSklremgREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEG
||.|.      ..|| |||| .   ... | |.  |  .  .|..|...... ..  . | |.|| |  ||..|||...  .. .. .|.. ...  .. 
ivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE-Y
.| ||||||||||||.|.| |.|.||. |  ||....|. || ||. .||   ||.|.| | || .
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1526-1772 1e-83 275.4 In-house 4-248 (250) alignment 
Range on Protein: 1526-1772
Range on HMM: 4-248/250.0
ANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREkCHQYWPAERS
|. |.|| |||  .| ...  || |.. .| . |||||||...||..|.|.||||||| .|.||||||..|..|. ||||..|.|.... .|||||.|..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQEGPISVHCSAGVGRTGVFITLSVVLER
 .|    |...|. ..  |. |..|.. |.  ..|..||..|. ||..|||.  .  .... .|.....|  ...|. |.|||||||.| ||... ||||
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavler

MRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFDHY
.. | .||.|. .|.||..|| .|....|| |.|...|..| |.. |
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy
subfamily_PTPN6_pd Subfamily PTPN6 1217-1473 2.9e-83 274.4 In-house 26-295 (306) alignment 
Range on Protein: 1217-1473
Range on HMM: 26-295/306.0
MLFSQEYESI---EPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSpMEGLPGSDYTNANYCDGY--RKQNAYIATQGPLLETMADFWRMVWEQRTN
  |..|.|..   |  .... ....  .|| |||| |.. .||.||||.  ...||||| |||| ..    ....|||||| | .|..|||||||.. ..
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

TIVMMTKLEERNRVKCDQYWPTRD-QEKYGFIQVTLLDTTELATYTVRSFALV-KNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSC----NP
 |||.||  ||.. || .|||.   .|.|| |.|| .. ..||.|..|.. .  |... |.||| |..|..|||||||..   ||.|.. |..     . 
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

PDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEK---TVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
 .|||||||||||.||||..|||| .|. |....    .||.  |  .|.||. .||||.|| |...|. .
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1508-1765 8.3e-83 273.1 In-house 2-255 (284) alignment 
Range on Protein: 1508-1765
Range on HMM: 2-255/284.0
NEFKRLASQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSk
 ||.|.. . .. .    ||.. || |||. .| ... |.| |... |.|.|||||||.| ||.... |||||||| .| .|||||.||.|.. ||.|. 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

lremgREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEGPISVHC
     ..|| |||| .   ... | |.  |  .  .|..|...... ..  . |.|||| |  ||..|||...  .. .. .|.. ...  .. .| |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE-Y
|||||||||.|.| |.|.||. |  ||....|. || ||. .||   ||.|.| | || .
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPRK_pd Subfamily PTPRK 1505-1764 9.2e-83 272.6 In-house 23-275 (314) alignment 
Range on Protein: 1505-1764
Range on HMM: 23-275/314.0
GMENEFKRLASQkaqpsrFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVM
|. .|.. |         . .|.   |. |||  .| .|.  || |..| |   ||||||. ||.|.. .|.|.||||| ||..||||.....|.. |||
gfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivm

LSKLREMGREKCHQYWPAERSArYQYFVVDPMSEYNMPQYILREFKVTDARDG--QSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQEGPI
|..| | || || .||| . .  |. . |  ..     ... | |.|. .  |  . |..|||||. ||. .||.| .|..... .|.|..|.  ..|.|
ltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGri

SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
 |||||| ||||.||....||. .. ||.||.|..|| ||.... ||.||.||.|.| ..||
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
Y_phosphatase Protein-tyrosine phosphatase 1531-1764 1.5e-82 272.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 1531-1764
Range on HMM: 1-235/235.0
NKFKNRLLNIQPYEGNRVCLqpiRGVEG-SDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWP--AERSAR
|| |||  .| ||. .|| |   .| || ||||||....||.. ...||||||| .| ||||||.|......|||| .| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-SEY-NMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQEGPISVHCSAGVGRTGVFITLSVVLE
|. . |  . .|  .. .|.||......  .  ..|...|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|...||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
... |. ||..|.||.||.||| |||...||.|.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1531-1764 1.5e-82 272.0 In-house 1-235 (235) alignment 
Range on Protein: 1531-1764
Range on HMM: 1-235/235.0
NKFKNRLLNIQPYEGNRVCLqpiRGVEG-SDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWP--AERSAR
|| |||  .| ||. .|| |   .| || ||||||....||.. ...||||||| .| ||||||.|......|||| .| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-SEY-NMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQEGPISVHCSAGVGRTGVFITLSVVLE
|. . |  . .|  .. .|.||......  .  ..|...|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|...||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
... |. ||..|.||.||.||| |||...||.|.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1501-1763 1.3e-81 268.8 In-house 18-276 (288) alignment 
Range on Protein: 1501-1763
Range on HMM: 18-276/288.0
ETITGMENEFKRLASQKAQPSRFvSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNST
.. ||...|.. ||. . . |    .. . |. |||  || ||. .|| |.    ..|.||||||.|||......|||||||||.| .|||.. .|....
rnrtgfseeynsLaalektksvt.agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

IIVMLSKLREMGREKCHQYWPAERS-ARYQYFVVDPMSEYNMPQYILREFKVTdaRDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqE
 ||||..| | |..||..|||..    .|  . |  ... .. ...||.. .   .... ..| |.|.. ||..|||.| . ..... ||. ....    
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..t

GPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAAL
||| |||||||||||.||.|  ...... |  .|.. ||. || ||. .|||. ||.|.|.. |
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN6_pd Subfamily PTPN6 1481-1766 1.7e-81 268.6 In-house 3-297 (306) alignment 
Range on Protein: 1481-1766
Range on HMM: 3-297/306.0
EVHARNLYGHIQKLTALEPGETITGMENEFKRLASQKAQP-SRFVSANIPANKFKNRLLNIQPYEGNRVCLQpIRGVEGSDYINASHIDGY--RQRNAYI
.. |...  ....|.  |   . .|.|.||..|  ..|.       .. | || |||  || |.. .|| |.   .| |||||||. |..    ....||
sllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyi

ATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSAR-YQYFVVDPMSEYNMPQYILREFKVT-DARDGQSRTIRQFQFTDWPEQGV
|||| | .| .|||||.|..||..|||. |  | |.||| .|||.| . . |    |  .|| .. .|||||..|.   .....|...|..|..||..||
atqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgv

PKSGEGFIDFIGQVHKTKEQFG--QEGPISVHCSAGVGRTGVFITLSVVLERMRYEGI---VDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
||. . ..||. .|.. .|..   ..||| ||||||.|||| || . ..|. ....|.   .|. ..||..|.||  .||||.||.| |.|  .|.
pkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1195-1485 1.8e-79 262.0 In-house 6-294 (297) alignment 
Range on Protein: 1195-1485
Range on HMM: 6-294/297.0
SHPPIPVSQFQEHIErlKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKqnAYIATQGPL
   |||.|.|   ..  |. .. .||.|.  .   . ..   ..   | .|.||.|.. || |||.|  ..  | ||| || .  |...   .|.|| | 
errpiplsdfatlvq..knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

LETMADFWRMVWEQRTNTIVMMTKLEERNRvKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPE--HATS
 .|.||||.||......||||.....||.. || .||. .   ..| . |.|| ..|   .  |.. . |...  .| |||.||. |||. |..  .|.|
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

VLAFISRVKSCNPPDAG-PIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHAR
.| .|| |.      |  |..|||.||||||| .. |||.. ..|.||.|||.| |. || .| |.|||.||| |...|. ||. |  |...| 
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
0037934 (Phosphotyrosine protein) phosphatases II 1234-1473 1.6e-78 258.9 In-house 2-240 (243) alignment 
Range on Protein: 1234-1473
Range on HMM: 2-240/243.0
WDHSNLETNKPKNRYANVIAYDHSRVILspmeglPGSDYTNANYCDGYRKqnaYIATQGPLLETMAD----FWRMVWEQRTNTIVMMTKLEERNRVKCDQ
. ...|. |..|||| ....||||||.|      .|||| |||.......   .||||||| || .|    ||||.||.....|||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPtrDQEKYGFIQVTLLDTTELATYTVRSFALVKNR-SMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSC--------NPPDAGPIVVHCSAGVG
|||  ... || ..||||....|. |||| . |.    . ..|.| ......|||||||.. ...|.|.. |...        . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGAYIVIDSMLERIkhekTVDIYGHVTCLRAQRNY-MVQTEEQYIFIHEALYE
|||..|... ||...    .||..  |  ||.||.. .|||..||.|..|||.|
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1202-1483 1.7e-78 259.0 In-house 5-287 (439) alignment 
Range on Protein: 1202-1483
Range on HMM: 5-287/439.0
SQFQEHIERLKGNDAMLFSQEYESIEP---GQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETM
..||||.|.|. |.  .|....|.|.      .        | ...|||| .| |.||.||.|  . |.| | | |||| .|| ... |||||||  || 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

ADFWRMVWEQRTNTIVMMTKLEERNRvkcdqYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEK--REVKQFQFTAWPDHGVPEHATSVLAF
 ||||.|.|..| ||||.|.| |  .     |||. ..  || | |      ||  |..| | ....|   .  | | ||...||||. || .|. || |
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

ISRVKSCNPP-DAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVH
.  ..|.|   . ||.||||||||||||. | .|  ||..| |. ||| | |. || ||. |||.  ||.||..|. | .  | . | 
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1503-1772 3.1e-78 257.6 In-house 19-289 (290) alignment 
Range on Protein: 1503-1772
Range on HMM: 19-289/290.0
ITGMENEFKRLASQKAQpSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEG--SDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNST
 .|..|.||.| | . .      .. . || .||  || .|. ||. |.|| | .    .||||..|.||.....|||||||. .|  |||...|....|
negfrnqfkmldsgese.htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvt

IIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqE
||||| .  |.|..||.||||.. ...|..| .  ..| .. .|| |...|.. .  |..... |.|.| |...|  .  .. .  | .. ||. . | .
iivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.n

GPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFDHY
..| ||||..|||..||... . ..... || .|.|| .| .|.|.| .|||..|||. ..  |.|| ||. |
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN12_pd Subfamily PTPN12 1230-1477 1.1e-77 255.7 In-house 28-279 (290) alignment 
Range on Protein: 1230-1477
Range on HMM: 28-279/290.0
QQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQ
.... .... |.|. |||| ... ||.||| || .|. .|||| |||.  |  .. .|||.|||| .|. |||||.||.... .||. .. | .. ||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPTRDQEK--YGFIQVTLLDTTELA-TYTVRSFALVKNrsMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYI
||| . .|.  .| ..||| .   .   ...|.... ..   |.|.|.||..|||||||||. |.|.|..|. |.. .  .. |.||||||||||||. |
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

VIDSMLERIKHEKT---VDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVAS
.|| . | .|.||.   .|..  |. || ||. .|||.||| ....|. | | .
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPN12_pd Subfamily PTPN12 1520-1766 2.4e-77 254.7 In-house 26-277 (290) alignment 
Range on Protein: 1520-1766
Range on HMM: 26-277/290.0
P---SRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKC
     .  ... . |. |||  .| ||. .|| |. |...||||||||..| |  .. .|||.||||..| .|||||.||.| .|.||. .. |.|. ||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

HQYWPAE--RSARYQYFVVDPMSEYNMP-QYILREFKVTDArdGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPISVHCSAGVGRT
..||| |  .. ... | |. ..| ..  ....| .||.    ..||...||..|.||..|||.| .  ...| .|....|   .. |. ||||||||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrt

GVFITLSVVLERMRYEGI---VDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
|. |..  | | .. | |   .|.|. |  ||.||.|.|||..||.. |.| .|..
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0037934 (Phosphotyrosine protein) phosphatases II 1525-1766 7.6e-77 253.4 In-house 4-242 (243) alignment 
Range on Protein: 1525-1766
Range on HMM: 4-242/243.0
SANIPANKFKNRLLNIQPYEGNRVCLqpirgvEGSDYINASHIDGYRQrnaYIATQGPLAETTED----FWRMLWEQNSTIIVMLSKLREMGREKCHQYW
 |..|.|. |||  .| ||. .||.|      ||||||||..|.....   .||||||| ||.||    |||||||...|.|||| .| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMSEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ------FGQEGPISVHCSAGVGRT
|   . .|  |.|  .||.....|..|.....    |...|........ ||..||| | | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSVVLERMryeGiVDMFQTVKMLRTQRPA-MVQTEDQYQFCYHAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||..||.|.|.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1199-1478 8.2e-77 252.9 In-house 2-286 (290) alignment 
Range on Protein: 1199-1478
Range on HMM: 2-286/290.0
IPVSQFQEHIERLKGNDAMLFSQEYESIEPGQ-QFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPG--SDYTNANYCDGYRKQNAYIATQGPLL
|||..| |...  . .    | ....... |. ..|  . . . ||..||.||.. ||  |..| |. | .    .| || | .||.....|||||||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRS-MEKREVKQFQFTAWPDHG-VPEHATSV
.|..|||...|....  |||.|.  | ..||| ||||..|...|| ....||. ..| .|. | . . ...|  .|..|.|.|.|.|...| |....|..
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASG
|..  ..|    .  ..||||||..|||.. .....  ... | |  .|..  .  .| |.  .|||..|| .|.. . ... | 
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1241-1474 1.4e-75 248.5 In-house 6-239 (239) alignment 
Range on Protein: 1241-1474
Range on HMM: 6-239/239.0
TNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRK-QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRdQEKY
 || ||||||...||||||.|  .   | ||| ||.|   |    .||||||| .  .  |||||.|..|   |||.| | |  . || ||||     ||
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

GFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEK
  ..|||  |  .| | .|.| . .    |.| | |..|| |||.|||..||.|| .  ..   . | | | |.|||||||||||..|||.|| . |..|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
||||. .| ..| .| .|||| |||.||| |. ||
tvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1502-1766 2.1e-75 248.4 In-house 13-276 (281) alignment 
Range on Protein: 1502-1766
Range on HMM: 13-276/281.0
TITGMENEFKRLAS-QKAQPSRfvSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNST
  .|. .|.. ||. .  ....  ... ..|. |||  ||  |.  || ..|    . .|||||....||.. ..|||||||. .. ..||.|.|||. .
dnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

IIVMLSKLREMGREKCHQYWPAER-SARYQYFVVDPMSEYNMPQYILREFKVtDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQe
.|||. .  | |. |||.||| .. . .|  ..|  ..| . ..|| |.||. ....|..|...|...| ||..|||.. . ...|  .|.|..|.  . 
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.

GPISVHCSAGVGRTGVFITLSVVLERMR-YEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 |. .||||||||||..|.|  .....   .  .|. ..|. || .|  ||||  ||.| |.| |..|
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1233-1473 2.7e-75 248.0 In-house 19-266 (274) alignment 
Range on Protein: 1233-1473
Range on HMM: 19-266/274.0
TWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGL-PGSDYTNANYCDGYRK-QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQY
. .. ..  .. |||| ...  ..|||.|.. ..  . |.| ||||  ||.. ..||.|||||| .|.||||||....... |||.|||.|.|. || .|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPTRD----QEKYGFIQVTLLDTTELATYTVRSFALVKNRSmeKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCN---PPDAGPIVVHCSAGVGRTG
.|..     .|.|| ....  ...|   |.||.. | .  .  .|.|| . .|.|||| .|..|...| ..  |.. .      ..|.|||||||.||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

AYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
..| |.  . ....|..||. . |. || .|  ||||.||| .||.||..
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1241-1472 4.1e-75 247.0 In-house 7-238 (239) alignment 
Range on Protein: 1241-1472
Range on HMM: 7-238/239.0
TNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRK-QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRdQEKY
 || ||||||...||||||.|  .   | ||| ||.|   |    .||||||| .  .  |||||.|..|   |||.| | |  . || ||||     ||
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

GFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEK
  ..|||  |  .| | .|.| . .    |.| | |..|| |||.|||..||.|| .  ..   . | | | |.|||||||||||..|||.|| . |..|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALY
||||. .| ..| .| .|||| |||.||| |. 
tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN13_pd Subfamily PTPN13 1235-1475 6.4e-74 243.6 In-house 30-269 (273) alignment 
Range on Protein: 1235-1475
Range on HMM: 30-269/273.0
DHSNLETNKPKNRYANVIAYDHSRVILSPMEGlpgsdYTNANYCDGYRK--QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWP
. .. . || |||| ||. ||..||.|.   |     | ||..        .  |||.|||| ||..|||.|||||... |.|.|.  |...|||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

TRDQEK---YGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPpDAGPIVVHCSAGVGRTGAYIVID
 . ..|   .. ..|.||....| ...||..|. ...| | ||| ...|..||||||| .|...| |...|.. .  ||||||||||||.||.|..|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

SMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
 .|. |...| .|.   | .|| ||. .|||..||||...|. |..
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN3_pd Subfamily PTPN3 1232-1475 8.2e-74 243.0 In-house 31-275 (280) alignment 
Range on Protein: 1232-1475
Range on HMM: 31-275/280.0
FTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEglPgsDYTNANYCD----GYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKC
 . .....  | .|||| ....||. ||.|.  |     || |||| .    .    | |||||||| .|..|||.|||||....|||.| | || ||||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DQYWPTR-DQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYI
 ||||.  |. .|| ..|..  . |  .| .| . | .... |.|.. |.|..||||||||......| |..||...   .  |.|||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
...  |  | ... | .   |  .| ||  .|||..|| |. ||. .. 
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1199-1510 1.5e-73 242.8 In-house 5-323 (325) alignment 
Range on Protein: 1199-1510
Range on HMM: 5-323/325.0
IPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETM
| | .. ||.|. | .|   |..|.. . . .  .   . .  || |||. ||.|.|.|||.|  ..  | ||| ||.|   ..|.. ..|.| || .|.
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

ADFWRMVWEQRTNTIVMMTKLEERnRVKCDQYWPTR--DQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAF
 |.||.| . |.  .|.. .|..    .| .||| .  .  ..| ..| |    |.. |  | . . . .  | | |||||. .|.| ||... ......
ndlWrlvldWrcsvvvvlneldlg.kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

ISRVKS------CNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGH
.  ||       .|   ..||.|||||||||||..| . |.|... .|  |||.| |  ||..|  ||.| .|||.|.||| ||. || |.|   ..  .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLTALEPGETITGMENEF
.  |   .|      .|.||
lsslqernpltqklniekef
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1241-1472 4.5e-73 240.4 In-house 2-236 (237) alignment 
Range on Protein: 1241-1472
Range on HMM: 2-236/237.0
TNKPKNRYANVIAYDHSRVILSPMEGlpGSDYTNANYCDGYRK-QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQE-K
 || ||||.|..|||||||.|    .  |||| ||.| .|.    . |||.||||  .  |||.|||...   |||.| | |.|..|| .|||  ||   
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGFIQVTLLDTTELATYTVRSFALVKNRSM-EKREVKQFQFTAWPDHGVPEHATSVLAFISRVKS--CNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERI
|| . |.|    |.. |||||. |.|. .. | | ..|.|||.|||.|||......| |  ..       ...|| ..|||||||||| ..|||.|| . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALY
| .| |||| .| ..  .| |..||..||.|||... 
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1492-1772 1.1e-72 239.4 In-house 8-284 (287) alignment 
Range on Protein: 1492-1772
Range on HMM: 8-284/287.0
QKLTALEPGETITGMENEFKRLASQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpirgVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFW
 ...| .. .  .| .| |. | . . ..     .  . || |||| .| ... .|| |.     |  |||||..||||....|.|....|...|  .||
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVH
......| |.||||....|  .|.|.|||| |.|  .  . .  ..|  . .|| |...|.    .|. ....|.|.|.|...|  .. .  .  | .  
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy

KTKEQFGqEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFDHY
||. . | ...| ||||..|||...|.   . ... . ||..|.|| .|  | |.| .||| .||.| ... |||| ||. |
ktqrkrg.ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_PTPN3_pd Subfamily PTPN3 1510-1762 5.7e-72 237.0 In-house 21-271 (280) alignment 
Range on Protein: 1510-1762
Range on HMM: 21-271/280.0
FKRLASqKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpirGVEGsDYINASHI----DGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVML
|..|   | .      |. |.|  |||  .| ||.  || |.     |  |||||...    ..  . | |||||||||.|..|||.|.|||.|..||||
feqlyr.kkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

SKLREMGREKCHQYWPAE-RSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPISV
  | | || ||||||| .  . .|  | |   .| .  .|.|||. ..|..  ..|.| |.|...||..|||.. . |..|. .|.|...  |.| |. |
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvvv

HCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAA
|||||.|||||.|.| . |  .  .  | . . |...| || ..|||..||.|  .| 
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1199-1482 2.2e-71 235.2 In-house 2-285 (287) alignment 
Range on Protein: 1199-1482
Range on HMM: 2-285/287.0
IPVSQFQEHIERLKGNDAMLFSQEYESIEP-GQQ-FTWDHSNLETNKPKNRYANVIAYDHSRVILSpmegLPGSDYTNANYCDGYRKQNAYIATQGPLLE
|||..| | ... . .    |.. .  .|  .|.     |.  . ||.|||..... .|  ||.|         || || . |||....|.|....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNR-SMEKREVKQFQFTAWPDHG-VPEHATSVL
|. .||....... ..|||.....| .. .| ||||. .   .|  ...||. .  | |..| . . ..  . .|..|||.|.|.|...| |.|..|..|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

AFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEV
 .  ..|.   .  ..||||||..|||.. .. ..  ... | | ..|..  .   | |.  .||| |||.|| ... | . |..| .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1530-1766 2.4e-71 235.4 In-house 42-276 (515) alignment 
Range on Protein: 1530-1766
Range on HMM: 42-276/515.0
ANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPA--ERSAR
 |  |||  || ||. .|| |. |     |||.|||.| ..   .||||.|||.  ...||||.....| | |.|..||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMSEYNMPQYILREFKVTDARDgqSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqeGPISVHCSAGVGRTGVFITLSVVLERMR
. .. |. .|     . | |...|.   |  |||. ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
   .||.|..|. .| .|| .|||..|| | | | ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1519-1766 2e-69 228.9 In-house 32-277 (315) alignment 
Range on Protein: 1519-1766
Range on HMM: 32-277/315.0
QPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQ
...|  .|  . |  |||  || |.. .|| |. |     |||||||.| .. . .||||.||||  . .|||||..... | |||..|..|  . || |
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPA--ERSARYQYFVVDPMSEYNMPQYILREFkVTdARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQEGPISVHCSAGVGRTGVF
|||     |...  . |. .|     . . |.. ||  .  .|||. |||||.||..||.|    .. .| .|   ...  .| .. ||||||||||||.
ywPdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvv

ITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
|..  |..... .  ||.|..||.||..|| .||||..| | | | ||.|
isidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1525-1767 2e-69 228.8 In-house 22-269 (274) alignment 
Range on Protein: 1525-1767
Range on HMM: 22-269/274.0
SANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEG-SDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPA
  ... .. |||  .| | |  ||.|..  . .  |.|||| .| ||..  .||.||||||..| .|||||........|||| ||.|. ..||..|.| 
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

ERSA----RYQYFVVDPMSEYNMPQYILREFKVTDARDgqSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQE-GPISVHCSAGVGRTGVFI
....    ||. . .   .  .  .| .|.. .  . .  .|..  . .||||.. .|.. . ..|.. .|....|.  .. .|. ||||||.||||.||
aedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

TLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLG
. |. . ..| |..||....|  || .|  ||||..||.. ..|  .|| 
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN13_pd Subfamily PTPN13 1507-1768 3.2e-69 228.2 In-house 14-271 (273) alignment 
Range on Protein: 1507-1768
Range on HMM: 14-271/273.0
ENEFKRLASQKAQPSRfVSANIPANKFKNRLLNIQPYEGNRVCLQpirgVEGSdYINASHIDGY--RQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVM
..||| |   |.. .   ...  .|| |||  |. ||.  || |.     ||. |||||.|      ..  |||.|||| ||..|||.|.|||....|.|
aeefkelrelkpldtc.evgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LSKLREMGREKCHQYWPAERSAR---YQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQEGP
... .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| . ...|..||. |||.| . .. |. .| . ..   ..||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagP

ISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGS
| ||||||.||.|..||. |||. .  .  .|. ..|. || || ..|||.||| |.|.|.|| |.|
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1198-1515 1.5e-68 226.0 In-house 3-277 (392) alignment 
Range on Protein: 1198-1515
Range on HMM: 3-277/392.0
PIPVSQFQEHIERLKgnDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLET
||||.||   .|. .   . ||..|.  .   . .    .. | |..|||| |.. || .||.|  ..  | ||| || | ...  ..||||.|||   .
pipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MADFWRMVWEQRTNTIVMMTKLEERNrvkcdqywptrdqekygfiqvtlldttelatytvrsfalvknRSMEKREVKQFQFTAWPDHGVPEHATSVLAFI
. ||||||..... ||.|.|||.| .                                          .  ..| | ||.|| |||..||.|..|.| ||
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

SRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYGHIQKLTAL
  ||.     . |...||||||||||  | |||.. . |. . ||..  || .| .| |||||.||| ||. |. | .    | .    .  |.|.| . 
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

EPGETITGMENEFKRL-AS
  |.. . .  ||. | ||
sdGdvrskqlkefrslkas
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1530-1769 2e-68 225.7 In-house 50-287 (297) alignment 
Range on Protein: 1530-1769
Range on HMM: 50-287/297.0
ANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQrnAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGReKCHQYWPAERSARYQ
 |  |.|  || ||. .|| |. .     |||.|||.. |...   .|.|| |  .| .|||.|..... ..||||... |  . || .||. . .. . 
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfG

YFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK--SGEGFIDFIGQVHKTKEQFgQEGPISVHCSAGVGRTGVFITLSVVLERMR
. .|  .|  .   .| ||..||  .  . | ..|.||..||.. |..  | . ....| .|.|. .|  .|||. |||.||||||||..|.  |. ...
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqn.aegPllvhclaGvGrtgvlltidsvvaeak

YEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSF
 |  ||.|..||.|| .|| .|||..||.| | | ||.| | 
rekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1503-1767 1.6e-67 223.0 In-house 22-289 (325) alignment 
Range on Protein: 1503-1767
Range on HMM: 22-289/325.0
ITGMENEFKRLASQKAQpsRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTII
  |. .||. | |. ..   .  |  |.|| |||. |. ... .||.|.  .    |||||||..  ..... ..|.| ||..|..|.||.. . .....
qdgfahefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvv

VMLSKLrEMGREKCHQYWPAE--RSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ--
|.| .| . | ..| .||| |   | ..  . |  ..  ..  |. | ..| ....|..|...|||.  |.. ||.|    .| ..  |.. .|.     
vvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtant

--EGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLG
   .|| ||||||||||||||.|  .|...  |  ||.|. || || .||.||.| ||| ..|.|  |.. 
kastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_PTPN23_pd Subfamily PTPN23 1503-1765 5.4e-67 220.6 In-house 14-279 (288) alignment 
Range on Protein: 1503-1765
Range on HMM: 14-279/288.0
ITGMENEFKRLASQKAQPSRFVSANIP-ANKFKNRLLNIQPYEGNRVCLQpirgVEGSDYINASHIDGYRQR-NAYIATQGPLAETTEDFWRMLWEQNST
 |.....|| | ..... .|  |  |   .  |||  .| ||. |||.|.     .  ||||||.. .       .||||.||..|  |||.|..|| | 
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

IIVMLSKLREMGREKCHQYWPAERSA--RYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHK--TKEQF
.|||| .  |.|..|...|||... .  ... . |   |. ...... |..|..  .  . ....  |.| ||| |||.| | ...|...|..  ...| 
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

GQEGPISVHCSAGVGRTGVF-ITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
  . |. ||||||||||||| .  ..| |  . .|..|. | |. ||.||  |||...|..|.|.| ||.
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN14_pd Subfamily PTPN14 1508-1766 2.6e-66 218.7 In-house 27-296 (300) alignment 
Range on Protein: 1508-1766
Range on HMM: 27-296/300.0
NEFKRLASQKAqPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVeGSDYINASHIDGY--RQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVML
 |. |.. ...  . . .|. | |. |||  .. ||| ||| |.| .    ..|||||.|      ..  ||..||||  | .|||.|.|||. ..||||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

SKLREMGREKCHQYWPAE----RSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEG-
 . .| |.||...|.| .    ...... | |      . ...| . .|.     .. ||.  .|.||||..|||.  .||.... .|.  .... .|  
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

------PISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
      |. |||||||||||| |.  .... .  .  .|. .....||.||  .|||  ||.| |.. ..||
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN1_pd Subfamily PTPN1 1229-1475 1.6e-65 215.7 In-house 19-271 (290) alignment 
Range on Protein: 1229-1475
Range on HMM: 19-271/290.0
GQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGlpgsDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCD
 ..|.  ...|..|...||| .|  |||||..|   .     || ||.  .  . .  || ||||| .|.. ||.|||||.. ..||. |. |....|| 
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPTRDQEKYG-----FIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKS--CNPPDAGPIVVHCSAGVGR
||||. ..||        ..|.|. . .  .|||| . | . .. | ||. .| .|.||| ||||  .. | |. .|..  .  .| || |.|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGAYIVIDSMLERIKHEKT---VDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
.|.....|..| .|....    |||  ..  || .|  ..|| .|  | . |. | .
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1504-1765 4.1e-65 214.8 In-house 24-278 (315) alignment 
Range on Protein: 1504-1765
Range on HMM: 24-278/315.0
TGMENEFKRLASQKAQPSRfvSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
 |...... .   . .| .   |.   || |||  || .|.  || |  .   ..|||.||. |||| ... |||.|||.... .||||...|.. . ||
ngfkqdyesipggqlhpld..vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv

MLSKLREMGREKCHQYWPAErSARYQYFVVDPMSEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqeGPIS
||..| |  ..|. .||| .    |  . |  .||    .|  | . |.   . . |.. |...| ||. ||||.   ....| .|.. ...    |.| 
mltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaiv

VHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
||||||||||| ||||. ||...  | ..|... .. .| .|  |||. .|||| | | || 
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_CG7180_pd Subfamily CG7180 1531-1766 2.3e-64 211.9 In-house 42-290 (296) alignment 
Range on Protein: 1531-1766
Range on HMM: 42-290/296.0
NKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGReKCHQYWPAERSARYQY
|. |||  .. ||. ||| |. . | | ||||||...|.. . ..|| |..|  || ..|||.......  .|.|.|  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMSEYNMPQYILREFKVTDA----------RDGQSRTIRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF---GQEGPISVHCSAGVGRTGVF
..|. ..| ....   |.||.|             . . |....||.| |.  . || | ...|... .|.. .|.     .|||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
... . || .. |. ||.|. ||.|| .|| .|.. ..|...|   ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_CG7180_pd Subfamily CG7180 1219-1478 3e-64 211.5 In-house 19-293 (296) alignment 
Range on Protein: 1219-1478
Range on HMM: 19-293/296.0
FSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTK
. .|.. ..  .. .  .   ..|. |||. .|. ||. ||.|. ..|   ||| || | |.. |...|| |..|  ||. .|||.|... ....|..||
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

LEERNRvKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKN----------RSMEKREVKQFQFTAWPD-HGVPEHATSVLAFISRVKSC----
  . .. .. .||| . .|.|| | | .. . ..|  . | | |.|.           ..|.| ||.||.| |.  . ||  ..... .. ||..     
tfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

-NPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASG
 . |. ||.||..| |..|.|.|. ||  || ...|. ||... |  || .|. .|.. |.| .| . | |||  .
dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1510-1766 5.1e-64 210.9 In-house 1-264 (270) alignment 
Range on Protein: 1510-1766
Range on HMM: 1-264/270.0
FKRLASQKAQPSRFvSaNIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKL
||.|  .....| .   ..  .|  ||  .| |    ||.|....  . . |||| .. |. . ...|||..|||. |...||||.||...| |||...|
fkeldkeetsesdl.p.eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

REMGREKCHQYWPAERSA----RYQYFVVDPMSEYNMPQYILREFKVTdaRDGQSRTIRQFQFTDWPEQGVPKSGE------GFIDFIGQVHKTKEQFGQ
 | ||.|| .|||||.      ..    |  .|| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... .
eEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldk

EGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
..|. |||||||||||..|.|  ... .  .. ||. . .. || .|.|.||. .||.| |.| .|| 
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1238-1473 1.3e-63 209.5 In-house 16-262 (270) alignment 
Range on Protein: 1238-1473
Range on HMM: 16-262/270.0
NLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQ-NAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ
.  ..|  ||||...   ..||.|...|  . . | ||||  |. .. ..|||..|||  |. .||||.||.....|||.|.|||..| ||..|||.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

E----KYGFIQVTLLDTTELATYTVRSFALVknRSMEKREVKQFQFTAWPDHGVPEHAT------SVLAFISRV-KSCNPPD-AGPIVVHCSAGVGRTGA
|    ..|.|.|. | ..    | ..   |   .. |.|..  |....|||||||...       ..|. .  | .|..  | |.|..||||||||||| 
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

YIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
 |..| ... ....| ||.   .. || .|  .||. ||| |...|. |
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPRN_pd Subfamily PTPRN 1505-1764 3e-63 208.3 In-house 30-290 (297) alignment 
Range on Protein: 1505-1764
Range on HMM: 30-290/297.0
GMENEFKRLASQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQR-NAYIATQGPLAETTEDFWRMLWEQNSTIIV
 .|.|.. |.. .|.||    |. . |  |||  .. ||. .|| |.     | ||||||| |     |  ||||||||||.|  |||.|.||| ...||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNM-PQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPI
.|..|.| | ..|..||| | |. |. . |. .||.    .|..| | . . .  ..||. || |  |||.||| |   ...|  .| |.    |.  ||
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpi

SVHCSAGVGRTGVFITLSVVLERMRyEGI--VDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
 ||||.|.|||||.| . .||.|.   |.  .|.  |.. || ||| .|.|.||..|.. |  |
vvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1504-1768 7e-63 207.1 In-house 15-295 (301) alignment 
Range on Protein: 1504-1768
Range on HMM: 15-295/301.0
TGMENEFKRLASQKAQPSRFVSANipANKFKNRLLNIQPYEGNRVCLQPIRG--VEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTI
...|...|.| ... ...     .  .||  ||  ||..|. ||. |.| .   .   .|||||.||||......||.|||. .|  ||||..|..  . 
nkfeeqykelkegedksctvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLSKLREMGREKCHQYWPAERSAR--YQYFVVDPMSEYNMPQYILREFKVT--D-------------ARDGQSRTIRQFQFTDWPEQGVPKSGEGFID
|||. .|.|  ..||.||||  .  .  .  | |  ..|...|....|...|.  |              .| .|... |.| ||||..|| .     . 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

FIGQVHKTKEQFGqEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGS
 | .| ... . |  ||. ||||..|.|.||....|. ||  . ||.||.|| .| .| ..| .|.| .|| . | .  .||  
viddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1215-1475 8.2e-62 203.6 In-house 16-293 (301) alignment 
Range on Protein: 1215-1475
Range on HMM: 16-293/301.0
DamlFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGL--PGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNT
.   |...|.... |.. . . .  |.||. ||. |.  ||. |.||.|.. |     .|.||.| |||......||.|||. .|..||||..|.... .
k...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMMTKLEERNRVKCDQYWPT--RDQEKYGFIQVTLLDTTELATYTVRSFALV-KN--------------RSMEKREVKQFQFTAWPDHGV-PEHATSVL
|||.|.|.|. . || ||||.   ..|..|...||| ... .  ...|..... ..              .... ..| |.| | ||..|| .|..| . 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

AFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
.    ..  . .. ||.|||||..|.|.| |. ..  ||  | |  ||... .  .| ..  .|.| |||..|.... . .
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_PTPRN_pd Subfamily PTPRN 1232-1475 1e-61 203.3 In-house 46-292 (297) alignment 
Range on Protein: 1232-1475
Range on HMM: 46-292/297.0
FTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANY-CDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQY
 | . .. | |  |||...|..|||||| |.       ||| ||    |   .. ||||||||| .|.||||.||||| .  ||..|.||| .  .|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPTRDQEKYGFIQVTLLDTT-ELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVID
||   .| |.. .| |.        | |||| |   .. | | | || | .||..|||  | |.| |  .|  .    . |||||||.|.||||.||.||
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SMLERI-KHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
 .|.|. |  | .||   .  || ||. .|.|..|. |.  |. | |
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_PTPN14_pd Subfamily PTPN14 1213-1473 2.3e-61 202.4 In-house 20-294 (300) alignment 
Range on Protein: 1213-1473
Range on HMM: 20-294/300.0
GNDAMLFsQEYESIEPGQQ-FTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLpGSDYTNANYCDG--YRKQNAYIATQGPLLETMADFWRMVWEQR
 .....| .||| | . ..  . . ..|. |..|||. .|. |...|| ||| .    ..| ||         |.  ||..||||  |. |||.||||| 
leegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqg

TNTIVMMTKLEERNRVKCDQYWPTR----DQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNP
.. |||.|. ||  . |. .|.|      .. ..|  .||   ...  ... ... |    | |.|.|  .|.| ||||||||  .. | .. .|.|   
vqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrr

---------PDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
             |..|||||||||||  |. | ... ..|....||   .. || || ..|||  || |....| .
ktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1216-1489 3e-60 198.5 In-house 8-280 (283) alignment 
Range on Protein: 1216-1489
Range on HMM: 8-280/283.0
AMLFSQEYESIEPGQQFTwDHSNLETNKPKNRYANVIAYDHSRVILSPMEGlpgsDYTNANYCD---GYRKQNAYIATQGPLLETMADFWRMVWEQRTNT
  || . .. .   .. . | .  . ||.|||. .....|  || | .       || || .      |.... ||..|.|| .|. |||.||....  .
nklfrevlkrlsvpdlda.diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSME-KREVKQFQFTAWPDHGVPEHATSVLAFiSRVKSCN-PPDAGP
|||.||| | .|.|| |||| |  |.||   ||| . |   ..... . | .| | . .  .  .|.  | . |      |.. |  .|.|       ||
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgP

IVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASGTTEVHARNLYG
||||||.|.|||...| . . .. .. |  ||..  |. .| ||  .||| .|| ..||.  |    | |.. | .|. 
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1508-1765 6.6e-60 197.4 In-house 13-265 (283) alignment 
Range on Protein: 1508-1765
Range on HMM: 13-265/283.0
NEFKRLASQKaQPSRFVSANipANKFKNRLLNIQPYEGNRVCLQPIRGvegsDYINASHID---GYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVM
. .|||.  . ...   ||.   || |||  .| |.. .|| |..       |||||..|     |.| . ||..|.|| .|  |||.|..... | |||
evlkrlsvpd.ldadiasad..enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSR-TIRQFQFTDWPEQGVPKSGEGFIDFiGQVhKTKEQFGQEGPIS
|.||.|  |.|| |||| . |  |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| 
ltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPiv

VHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
||||.|.|||.|||..|. .. .. | .||.|..||..| ||. .||| |||.. ....|| 
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1524-1766 1.1e-59 197.0 In-house 38-279 (439) alignment 
Range on Protein: 1524-1766
Range on HMM: 38-279/439.0
VSANIPA---NKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGRekchqYW
. |.. |   .. |||  .. ...  || || | ||  | |||| .|.|| . . |||||||  |||.||||...|.... ||||..| |  .     ||
ciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....yw

PAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDG--QSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQEGPISVHCSAGVGRTGVFIT
|..  . |   .|    . ..|.|..| ||| . ||   . ||. ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.
psdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiia

LSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
| . ||... |  ||.   ||.|| ||  |||.  || | | | || .
ldialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1231-1472 2.5e-59 195.4 In-house 27-274 (287) alignment 
Range on Protein: 1231-1472
Range on HMM: 27-274/287.0
QFTWDHSNLETNKPKNRYANVIAYDHSRVILSpMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQY
 .|.  ..   .  |||||.|. .|..||.||  ||  |||| ||||  .|....|.||.|||.  |. ||||.|.|.|. ....||.  |  | || .|
tatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyky

WPTRDQE-KYGFIQVTLLDTTELA-TYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRV-----KSCNPPDAGPIVVHCSAGVGRTG
|| |..  . |   |.||| . .   |.||.. |..  . | | |||... .|||....  | ... |.  |      . .  ..||.|||...|.||.|
wPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsG

AYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALY
 .. .  ...| .    ||.   |  || .|. .||.  |. .. ||| 
illatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN1_pd Subfamily PTPN1 1518-1764 6.4e-59 194.0 In-house 19-269 (290) alignment 
Range on Protein: 1518-1764
Range on HMM: 19-269/290.0
AQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGvegsDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCH
|.  .  .|. |.|. .||  ...||.  |. |.        |||||| ..  . .  || |||||..|.. ||.|.|||.|  .||| |. | .. ||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPAERS---ARYQ--YFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGR
|||| . .     ..   . |. .|| .  .|..| ..... .  ..|.| .| .| ||. |||.|   |..|. .| ..     . ||  .|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGVFITLSVVLERMRYEGI---VDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
.| |. .  .| ..  ..    ||. ...  || .|  ..|| || .| | | ||
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1506-1765 8e-59 193.8 In-house 12-276 (287) alignment 
Range on Protein: 1506-1765
Range on HMM: 12-276/287.0
MENEFKRLAS-QKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVM
...|...|    .. .  | .|.  |.  |||  .. |.. .|| |    |  ||||||| .. .|.. .|.||.|||.| |  ||||...|..|. ...
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LSKLREMGREKCHQYWPAERS-ARY-QYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQV--HKTKE-QFGQE
...  | .| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| ..|... .||..... .  |.| |. .|  |   . .  . 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
||. ||...|.||.|..... |...|.   | ||. ..|  || .| |.||.  |... | |   |
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPN23_pd Subfamily PTPN23 1240-1475 2.1e-58 192.4 In-house 41-280 (288) alignment 
Range on Protein: 1240-1475
Range on HMM: 41-280/288.0
ETNKPKNRYANVIAYDHSRVILSpmegLPGSDYTNANYCDGYRKQ-NAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ--
...  |||. ... |||.|| |         || || .  .   .   .||||.|| .|..|||.||.||....|||... ||... |.|.|||..    
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

EKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSC----NPPDAGPIVVHCSAGVGRTGAYIVIDSML
.|.| ..||| ...|. |.  | . |  ... ....|.  |.|.||..|||.   ..|.|.  |.|.    . .   |.||||||||||||.. .. . .
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ERIKHE-KTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
. ....   .||   |  ||.|| .|||..||. |  ||  ||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0051429 (Phosphotyrosine protein) phosphatases II 1557-1768 1.9e-57 190.2 In-house 2-227 (272) alignment 
Range on Protein: 1557-1768
Range on HMM: 2-227/272.0
EGSDYINASHIDGYRQ---RNAYIATQGPLAETTEDFWRMlWEQNSTIIVMLSKLREMGREKCHQYWP------------AERSARYQYFVVDPMSEYNM
. |.||||....|| .   ........|||  | .||||. .|.. . ||.| .. |.||.||..|||            .. . .| ...|  .||...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTIRQFQFTDWPEQGVPKSGegFIDFIGQVHKtkeqfgqEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVD-------
. |||||. .|     |..|.......||||  |||..   ..... ....       .||. ||||||..|||... |  .|... .| |||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-MFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGS
 ....|..|| |||..||||.||.|.|.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs
0051429 (Phosphotyrosine protein) phosphatases II 1267-1493 2.3e-56 186.7 In-house 1-242 (272) alignment 
Range on Protein: 1267-1493
Range on HMM: 1-242/272.0
LPGSDYTNANYCDGYRK---QNAYIATQGPLLETMADFWRMvWEQRTNTIVMMTKLEERNRVKCDQYWP------------TRDQEKYGFIQVTLLDTTE
|| |.| ||.. .|| .    .......|||  | |||||. .|.. .|||.....|||.|.|||.|||            .  .  ||.. |||| .. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LATYTVRSFALVKN-RSMEKREVKQFQFTAWPDHGVPEHAtsVLAFISRVKScnppdAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVD--------
|  |..| . |..     | ||| ....|.|||||||..|  .|.... . .      ||..||||||..||| ..... .|... .|  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAvASGTTEVHARNLYGHIQK
... |  ||||| ..|||||||.|..||| |. . . ..|.|. |  ... 
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaalda
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1530-1764 7.9e-55 180.7 In-house 2-237 (237) alignment 
Range on Protein: 1530-1764
Range on HMM: 2-237/237.0
ANKFKNRLLNIQPYEGNRVCLQPIRGveGSDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPA-ERSAR
 || |||  ||. |. .|| |.   .  |||||||....|.    . |||.||||  . .|||.|.|... ..||||. | |  ..|||.|||  .. | 
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YQYFVVDPMSEYNMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERM
|  . |    . .. .| .| . ..      . | | |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

RYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
. . .||... |. .  .|| ..||.||| | ... ||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1525-1766 9.8e-55 180.5 In-house 39-236 (392) alignment 
Range on Protein: 1525-1766
Range on HMM: 39-236/392.0
SANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGrekchqywpaer
.|. . |. |||  || ||. .|| |. |  .  |||.|||.|... . .||||.||| | . .|||||....| | |.|..||.|              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

saryqyfvvdpmseynmpqyilrefkvtdaRDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVhktKEQFGQEG-PISVHCSAGVGRTGVFITLSVVL
                              .  . ||. ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |.
..............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvv

ERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 . .   .||.|. |  .| .|| ||||..|| | | | || |
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1530-1764 2.5e-53 175.7 In-house 6-238 (239) alignment 
Range on Protein: 1530-1764
Range on HMM: 6-238/239.0
ANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSaRY
 || |||  ||  |. .|| |. .     |||||||..  |    .||||||| .. .. |||||.|..   .||||. | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRY
  . |       . .||.| | ...  . . | . |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
.  ||.|. || .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1530-1764 3.3e-53 175.3 In-house 7-239 (239) alignment 
Range on Protein: 1530-1764
Range on HMM: 7-239/239.0
ANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSaRY
 || |||  ||  |. .|| |. .     |||||||..  |    .||||||| .. .. |||||.|..   .||||. | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRY
  . |       . .||.| | ...  . . | . |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
.  ||.|. || .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
0041856 (Phosphotyrosine protein) phosphatases II 1242-1476 4e-53 175.0 In-house 1-172 (182) alignment 
Range on Protein: 1242-1476
Range on HMM: 1-172/182.0
NKPKNRYANVIAYDHSRvilspmeglpGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTkleernrvkCDQYWPtrdqekygf
|..|||| ... |||||          ..|| |||. .|..... .||||||||.|.|||.||..|.. .|||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iqvtlldttelatytvrsfalvknrSMEKREVKQFQFTAWPDHGVPEhATSVLAFISRVKScnppDAGPIVVHCSAGVGRTGAYIVIDSMLERikhekTV
                         . ..|.. |.... |||||||.   ..|.|| .|..    . ||..|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVA
...  |  .| .|. ||.|..||.|.. ||.| . 
sleeavklvrsrRpgmvitpnqyfflqlallelll
0036282 (Phosphotyrosine protein) phosphatases II 1558-1759 1.4e-51 170.0 In-house 1-163 (174) alignment 
Range on Protein: 1558-1759
Range on HMM: 1-163/174.0
GSDYINASHIDGYRQRNAYIATQGPLAettedFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAersaryqyfvvdpmseynmpqyilrefkvtdARDG
||||||||..|...  . .||.|||||     ||.||.|...|..||| ...|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTIRQFQFTDWPEQGVPKSGEgFIDFIGQVHKTKEQfGQEGPISVHCSAGVGRTGVFITLSVVLERMRyEGIVDMFQTVKMLRTQRPAMVQTEDQYQF
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... .  .| ... |. || ...|..||.||| ||||..||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CY
.|
ly
0036282 (Phosphotyrosine protein) phosphatases II 1269-1469 1.8e-51 169.6 In-house 1-164 (174) alignment 
Range on Protein: 1269-1469
Range on HMM: 1-164/174.0
GSDYTNANYCDGYRKQNAYIATQGPLLetmadFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTrdqekygfiqvtlldttelatytvrsfalvkNRSM
|||| ||...|...  . .||.||||      ||.|..|.. .|.||.....|....|| .|||.                               .|. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKREVKQFQFTAWPDHGVPEHATsVLAFISRVKSCNPP-DAGPIVVHCSAGVGRTGAYIVIDSMLERIKhEKTVDIYGHVTCLRAQRNYMVQTEEQYIFI
..|.. |.... |||||||. .. .| |...|...    . ||..|||||||||||. .... || ... |..||.. .|  || || .||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HE
..
yy
0041856 (Phosphotyrosine protein) phosphatases II 1531-1766 2.3e-51 169.3 In-house 1-171 (182) alignment 
Range on Protein: 1531-1766
Range on HMM: 1-171/182.0
NKFKNRLLNIQPYEGNRvclqpirgveGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSklremgrekCHQYWPaersaryqy
|. |||  .| ||. .|          ..|||||. ..|..  . .||||||| .|..||.|||.|.. |.||.|.         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmseynmpqyilrefkvtdarDGQSRTIRQFQFTDWPEQGVPKsGEGFIDFIGQVHKtkeqfgQEGPISVHCSAGVGRTGVFITLSvvleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

iVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 |.....||..| .|| ||.|..||.|.. |.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell
0049772 (Phosphotyrosine protein) phosphatases II 1507-1766 1.9e-47 157.9 In-house 22-280 (314) alignment 
Range on Protein: 1507-1766
Range on HMM: 22-280/314.0
ENEFKRLASQKAQPSRFVSANIPANKFKNRLLNIQPYEgNRVCLqPIRGVEGSDYINASHIDGYrqrNAYIATQGPLAETTEDF----------WRML--
. ...|.     ..  .. |....|. ||| |.|.|.. |||.| |  .|.||||||||..||.   ...||||||| .| .||          |||   
llvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr

WEQNSTIIVM---------------------LSKLREMGrekchQYWPAERSARYQyfvvdpmSEYNMPQYIlrefkvtdardgqSRTIRQFQFTDWPEQ
...|. .|||                     | .| . |      ...|.. . ..       .|.. |..              .|.. ..  ...|  
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.......eelydpelf.............erlgikylripvpDg

GVPkSGEGFIDFIGQVHKTkeqfGQEGPISVHCSAGVGRTGVFITLSVVLERMryeGIvDMFQTVKMLRTQRP-----AMVQTEDQYQFCYHAALEYL
..| . | | .|.  ...      ..||. |||.||.||||.|...  .. ..   |. .. ......| .||      .... .||.|...| ||||
sap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1227-1473 3.7e-47 155.4 In-house 41-281 (290) alignment 
Range on Protein: 1227-1473
Range on HMM: 41-281/290.0
EPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSpmEGLPGsDYTNANYCDGYRkqNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVK
 |.|..  .  . .|.  |||| .|.  | .||||.  .| .| ||  ||| .| .    .| |||.| .|. |.|||| .... .|||. .| |  . |
lpvqylerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkak

CDQYWPTRDQEKYGFIQVTLLD---TTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCnppdAGPIVVHCSAGVGRTG
|.||.| .. |   | ..|.|    ... |    . ... .  |  .  .| ..  .|||. |.  . ..|  .  ..      .||.|||||||.||||
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtG

AYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
... |.  |. . . | .|. . |  ||  |   || . ||. . |.| .
tfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1238-1474 1.3e-46 154.1 In-house 37-276 (307) alignment 
Range on Protein: 1238-1474
Range on HMM: 37-276/307.0
NLETNKPKNRYANVIAYDHSRVILSpMEGLpGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQE
 ...|  |||| .| . |..|...  ..||  |||  |||     | . .|..|||| .|. .|| |. ... ....|. |. |  ..||.||||  . .
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

KYGF------IQVTLLDTTELATY--TVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKScnppDAGPIVVHCSAGVGRTGAYIVID
|  |      | |. | . .||     .   .|  . . . | ....|.. |||.|||.   . . ... |.     |  |.||||||||||.|. . | 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivais

SMLER-IKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
 . .. |. .   |.   |  ||.||.| .||| ||...|  | | 
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0043147 (Phosphotyrosine protein) phosphatases II 1557-1760 3.7e-46 152.3 In-house 3-155 (172) alignment 
Range on Protein: 1557-1760
Range on HMM: 3-155/172.0
EGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLremgrekchqywpaersaryqyfvvdpmseynmpqyilrefkvTDARD
|||||||||..|.|.  . .||||||| .|..||||||.|.. |.||.| .|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTIRQFQFTDWPEQGVPkSGEGFIDFIGQVHKTKeQFGQEGPISVHCSAGVGRTGVFITLSVVLERMryegivDMFQTVKMLRTQRPAMVQTEDQYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... .  .|...      .....|...|..|| .||...||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FCYH
|.|.
flyy
0046846 (Phosphotyrosine protein) phosphatases II 1550-1767 5.1e-46 151.9 In-house 3-174 (176) alignment 
Range on Protein: 1550-1767
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASHIDGYRqrnaYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYqyfvvdpmseynmpqyilref
|...   ...|||||. |.|.|    .||||||| .|..||..||.|.. |..|.| ...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtirQFQFTDWPEQGVPKSgEGFIDFIGQVHKTKEQfGqeGPISVHCSAGVGRTGVFITLSvvleRMRYEGIVDMFQTVKMLRTQRP-AM
              |.....||. ||| . | ..... ....  .. |  ||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke.g..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDQYQFCYHAALEYLG
|||..||.|.|...|..|.
vqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 1268-1469 8.2e-46 151.2 In-house 3-155 (172) alignment 
Range on Protein: 1268-1469
Range on HMM: 3-155/172.0
PGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLeernrvkcdqywptrdqekygfiqvtlldttelatytvrsfalVKNRS
.|||| ||.| |.|.. . .||||||| .|.||||||..|.  ..||..|.|                                           .....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

MEKREVKQFQFTAWPDHGVPeHATSVLAFISRVKS-CNPPDAGPIVVHCSAGVGRTGAYIVIDSMLerikheKTVDIYGHVTCLRAQRNYMVQTEEQYIF
 ..|.. |.... ||||||| ..  .| |.. ... ..  . ||..|||||||||||. .... ||      . ....  |  .|..|...||...||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IHE
...
lyy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1235-1474 1.2e-45 150.6 In-house 26-258 (267) alignment 
Range on Protein: 1235-1474
Range on HMM: 26-258/267.0
DHSNLETNKPKNRYANVIAYDHSRVILSPMEglpgSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNrvkCDQYWPTR
  |  | |. .||. ... ||..||||.  |     .| || | .||...||.|.||.||  |..||. .. .|.  .||..||  . |     ..|| .
sqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPk

--DQEKYGFIQVTLLDTTELATYTVRSFALvKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFIsRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSML
  . .||  . |      |   | . .. | | .    ..|  . .  |      .     |  |   |        |.||.||.||||.|...||||.|
mgqakkyqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgi.laknqlengnrPlvvacsdGvGrsGtflvidsql

ERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
||.|.| ..||.  .  .| ||  .|.| |.||.||| | | 
eraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0046846 (Phosphotyrosine protein) phosphatases II 1267-1473 6.5e-45 148.3 In-house 9-171 (176) alignment 
Range on Protein: 1267-1473
Range on HMM: 9-171/176.0
LPGSDYTNANYCDGYRkqnaYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTrdQEKYGFiqvtlldttelatytvrsfalvknr
 ...|| |||. .|.|    .||||||| .|.|||..|..|.. ...|..|.. | .|.||..|||    ||.|.                         
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.........................

smekrevkQFQFTAWPDHGVPEHaTSVLAFISRVKSCNPPDaGPIVVHCSAGVGRTGAYIVIDsmleRIKHEKTVDIYGHVTCLRAQRN-YMVQTEEQYI
        |.... |||||||.. . .| ..  ....   . ||..||||||.||||......     ...|| ....  .  .|.||  ..|||.||| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHEALYE
|..|....
flyefell
0049260 (Phosphotyrosine protein) phosphatases II 1278-1469 6.2e-44 144.7 In-house 2-144 (152) alignment 
Range on Protein: 1278-1469
Range on HMM: 2-144/152.0
CDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWptrdqekygfiqvtlldttelatytvrsfalvknrsmekrevkQFQ
 |||......||||||. .|.||||||..|.  .||||.|.|.|....||.||.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLerikheKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHE
.. |||||||...  .| ..  .. ..  . ||..|||||||||||...... ||      . |...  |  .|..|...|....|..|..|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 1232-1476 3.1e-43 144.0 In-house 36-281 (314) alignment 
Range on Protein: 1232-1476
Range on HMM: 36-281/314.0
FTWDHSNLETNKPKNRYANVIAYDhSRVILsPMEGLPGSDYTNANYCDGYrkqNAYIATQGPLLETMADF----------WRMV--WEQRTNTIVM----
.|.  ..|. |. |||| ... .| .|||| | ..  |||| ||.| ||.   ...||||||| .|. ||          ||||  ..... .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTKLEERNrvkcdQYWPTRDQEKYGfiqvtlldttelatytvrsfA-------LvknrsmeKREVKQFQFTAWPDHGVPeHAT
                  ..| ...      ... .|.| .                             .       .|.. ..  . .||...|    
vladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelf.......erlgikylripvpDgsap.lle

SVLAFISRVKSCnpPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHeKTVDIYGHvtcLRAQRN-----YMVQTEEQYIFIHEALYEAVA
 ...|.  ....  .. ||..|||.||.|||| ..|.. .. . .     ... .   .|..|       .... |||.||.|||.|.. 
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealed...vrlkRpinpnpgfieqleqyefilealleylk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1504-1766 9.2e-43 141.4 In-house 16-277 (307) alignment 
Range on Protein: 1504-1766
Range on HMM: 16-277/307.0
TGMENEFKRLAsqKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpIRGVeGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
. . .||. ||  | .|       . ||  |||  ...  . .|. .. . |.  |||| | ..    . . .|..|||| .|  .|| |  ...   ..
qalvdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MLSKLREMGREKCHQYWPAERSARYQYFVV-DPMSEYNMPQYILR----EFKVTD---ARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeq
|| |. |... ||.||||.|.  .  .    . .|  |.    |       .||.      ..||||...|...||..|||.   . |...  |.     
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.....

fGQEGPISVHCSAGVGRTGVFITLSVVLERM-RYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 ... |. |||||||||.|  ...|.| ..| . .   || . |. ||.||.  .||| || . .   |||.
.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1507-1765 3e-42 139.5 In-house 9-258 (267) alignment 
Range on Protein: 1507-1765
Range on HMM: 9-258/267.0
ENEFKRLASQKAQPSRfVSANIP-ANKFKNRLLNIQPYEGNRVCLQpirGVEgSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVML
|.||. .     . |. .|  |.  |. .||| .  ||. .|| |.     |  .|||||...||...||.|.||.||  |  ||. .. .|. ..||.|
ekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

SKlreMGREKCHQYWPAE--RSARYQYFVVDPMSEYNMPQY--ILREFKVtdaRDGQSRTIRQFQFTDWPEQGVPKSgeGFIDFIGQVHKTKEQFGqEGP
 |    . .. ...|| .  .. .|| ..|.   | .  .|  |  |.|.   ..  .. .  . .  |  .   |    .  ..| . | . . | . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.nrP

ISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
. |.||.||||.| |...   |||.. ||..|.|. .. .| ||...|.| ..| ....   ||
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049260 (Phosphotyrosine protein) phosphatases II 1567-1759 3.7e-42 138.9 In-house 2-143 (152) alignment 
Range on Protein: 1567-1759
Range on HMM: 2-143/152.0
IDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWpaersaryqyfvvdpmseynmpqyilrefkvtdardgqsrtirQFQ
||||.. ...||||||. .|..||||||.|.. |.|||| .| |.|..||.||.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTDWPEQGVPKSGEGFIDFIGQVHKTkeQFGQEGPISVHCSAGVGRTGVFITLSVVLermryeGIVDMFQTVKMLRTQRPAMVQTEDQYQFCY
.. ||  |||.. . .....  ..|   .  ..||. |||||||||||... .  .|        |.....|...|..|| .|....|..|.|
hlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_ptpA1_pd Subfamily ptpA1 1238-1437 6.2e-42 138.8 In-house 43-258 (418) alignment 
Range on Protein: 1238-1437
Range on HMM: 43-258/418.0
NLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGY-RKQnaYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTR--
. . |  ||||.|..  .|.|| |  ..   |||| |||| ||   ||  .|.||||| .|.|||||||||.|   |||...  |  |.|||.||| .  
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

---------DQEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFI---S-RVKSCNPP--DAGPIVVHCSAGV
          .| .|   | |..  .     . .  .      | |.. |.|.  |||| .|.|.  .  ..   . | .   |      ||.|||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGAYIVIDSMLERIKH
||||..     |.... |
grtgtfctavimmkkldh
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1240-1472 3.2e-41 135.9 In-house 53-286 (305) alignment 
Range on Protein: 1240-1472
Range on HMM: 53-286/305.0
ETNKPKNRYANVIAYDHSRVILSPMEglpGSDYTNANYCDGY-RKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEK
. .. ||||..| . |.| | |.       |||  |||       .. .|..|||| .|. .|| || ... . |||. |  |  ..|| ||||.   ||
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

YGFIQVTLLDTTELATYTVR----SFAL--VKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNppdaGPIVVHCSAGVGRTGAYIVIDSML
  .    ...    .    |      .|  .     .|  |...|.| ||| |||    . | ..| ..  .     |||||||||.||||. . |. .|
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyil

ERIKHEKTVD-IYGHVTCLRAQRNYMVQTEEQYIFIHEALY
|.|  .| .  .   | .|| || . .|.. ||.|||  . 
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1242-1472 5.7e-40 131.9 In-house 48-284 (305) alignment 
Range on Protein: 1242-1472
Range on HMM: 48-284/305.0
NKPKNRYANVIAYDHSRVILspmEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGF
.. |||| .|   |. || |   ||    .|  |||     . . .| || || .| |||| | .... ..| |. .| |.   || .|....|...  |
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

------IQVTLlDTTELATYTVRSFAL-------VKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKscnpPDAGPIVVHCSAGVGRTGAYIVI
      |.| . ....   ..  . |        ..    ..| |... .  ||| |||   ...| .. . .    |  ||||||||||.||||. ...
eekgqkisvkf.essvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvml

DSMLERIKHEKTVDIYGH-VTCLRAQRNYMVQTEEQYIFIHEALY
. .|...   . ..   . .  .| |||  .||..||.|.|. . 
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil
0044763 (Phosphotyrosine protein) phosphatases II 1542-1765 1.9e-39 130.5 In-house 1-170 (178) alignment 
Range on Protein: 1542-1765
Range on HMM: 1-170/178.0
PYEGNRVCLQPIRGVEGSDYINASHIDGYrqrnAYIATQGPlaettEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSaryqyfvvdpmseynm
|....||.|....|.|.|||||||.|...     |.....|     .|....|.|.. | ||.|..  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtiRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQEGPISVHCSAGVGRTGVFITLSVVLERmryeGIvDMFQTVKML
                      |.... .|  ||| . | | .|.  ...  .   ..||. |||||||||.|... .  ....    |. .... ....
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDQYQFCYHAALEY
| .|| .|....|....|  .|..
rerRp.ivpnpgqlrqLyefelrl
0051082 (Phosphotyrosine protein) phosphatases II 1558-1762 2.8e-39 129.4 In-house 2-149 (151) alignment 
Range on Protein: 1558-1762
Range on HMM: 2-149/151.0
GSDYINASHIDGYrqrnaYIATQGPlaetTEDFWRMLWEQNSTIIVMLSKLREMGreKCHQYWPAERsaryqyfvvdpmseynmpqyilrefkvtdardg
 |||||.| ..|.     .....||    ..||...|.|.. . ||.| .. |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfGQEGPISVHCSAGVGRTGVFITLSVVLERmryegiVDMFQTVKMLRTQRPAMVQTEDQYQF
  .........|||..|.| | . ...|. .. .      ..||. ||||||.||||... |  .|..      |.........| .|| .||...|..|
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYHAA
...| 
qlfal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1238-1473 1.2e-38 127.4 In-house 33-267 (281) alignment 
Range on Protein: 1238-1473
Range on HMM: 33-267/281.0
NLETNKPKNRYANVIAYDHSRVILSP-MEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ
|   |. ||||.|. . | ||| |   |     .||  |||      .  || ||||  || ||||||.|.. | .|||. .. | || || .|.|   .
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

EKYGFI--QVTLLDTTELATYtvRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCnppdAGPIVVHCSAGVGRTGAYIVIDSMLER
    |    |.  |.|   .    .  |      | | . .. .  |||  ||| .  .|  . ....     . | |.||||||||.|. . ..  |. 
cclqfdklsvsyedstvnksl..vttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialqs

IKHEKT-VDIYGHVTCLRA-QRNYMVQTEEQYIFIHEALYE
|.   |  ||   |. ||   |   ||| .||..| . | .
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_ptpA1_pd Subfamily ptpA1 1504-1726 1.5e-38 127.7 In-house 21-256 (418) alignment 
Range on Protein: 1504-1726
Range on HMM: 21-256/418.0
TGMENEFkRLASQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRnAYIATQGPLAETTEDFWRMLWEQNSTIIV
  ...|| ||  .   ||     .   |  |||  || | .  || |. |.  |||||||| .|||   .  .|.||||| .|  |||||.||.   |||
hkikeef.rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriiv

MLSKLREMGREKCHQYWPAERSArYQYFVVDP----MSEY-----NMPQYILREFKV---TDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
|||.  |  | || .||| .     |. .       .  |     .. |   ||        . .|..| | |.|.  ||.. .|   . | ...  . .
mlsresencrikcdrywpeqigg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitn

TKEQF----GQEGPISVHCSAGVGRTGVFITLSVVLERM
 ..|      .. || ||||||||||| | |  ......
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1223-1484 2e-38 126.7 In-house 33-298 (310) alignment 
Range on Protein: 1223-1484
Range on HMM: 33-298/310.0
YESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSpMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEER
|  ..  |. .  .   . .  ||||..|.  | ||| |  ..     ||  |||      ....| .||||  |. |||||....|...|... |  | 
yrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgee

NRVKCDQYWPTRD-QEKYGFIQVTLLDT-------TELATYTVRSFALVKNRS--MEKREVKQFQFTAWPDHGVPEHATSVLAfiSRVKScnPPDAGPIV
 | ||  |||.    | || |.|| |          .||   |     | ..   ...  |.  ..  ||| |||.     .    |. .      || |
grpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrlla..qvrhgpcv

VHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALyEAVASGTTEVHA
||||||..|... . ..  ...... . ||.   .| |. .|   .||| ||..|.     . | | |||  
vhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr.iifargetevae
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1506-1765 5e-38 125.3 In-house 13-268 (281) alignment 
Range on Protein: 1506-1765
Range on HMM: 13-268/281.0
MENEFKRLASQkaQPSRFV-SANIPANKFKNRLLNIQPYEGNRVCLQP-IRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
...||  |  .   || ..   | | |. ||| |||   .  || |.  .   . .||| | .|     .  || ||||  ||  |||||.|..|.| ||
fkqefsnlpgd..ppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQEGPIS
|| .. |  |||| .|.| .  .  |.  .    |    .  |   ..  . .|..| | .. . .||.  ||.| | ..  . ...       .  |  
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppv

VHCSAGVGRTGVFITLSVVLERMRY-EGIVDMFQTVKMLR-TQRPAMVQTEDQYQFCYHAALEY
.||||||||.| .... . |. ..    . |. | |  || | | | ||| .|| . ..  |..
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
PTPc_DSPc_SM00012 1661-1764 4.3e-37 121.9 In-house 1-105 (105) alignment 
Range on Protein: 1661-1764
Range on HMM: 1-105/105.0
TIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRYE-GIVDMFQTVKMLRTQRPAMVQTEDQYQFCY
|......|.||..|||.... ..... .|.| |.. ....|. |||||||||||.|..|...|.....| . ||.||.||.||.||| |||||.||.|.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

HAALE
.| ||
ralle
0051082 (Phosphotyrosine protein) phosphatases II 1269-1473 5.5e-37 122.0 In-house 2-151 (151) alignment 
Range on Protein: 1269-1473
Range on HMM: 2-151/151.0
GSDYTNANYCDGYrkqnaYIATQGPlletMADFWRMVWEQRTNTIVMMTKLEERNrvKCDQYWPTRDqekygfiqvtlldttelatytvrsfalvknrsm
 |||.|..| .|.     .....||    .|||.....|.  .|||.....|||.  .| .|.|  .                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekREVKQFQFTAWPDHGVPEHATSVLAFISRVKScnpPDAGPIVVHCSAGVGRTGAYIVIDSMLERikhektVDIYGHVTCLRAQRNYMVQTEEQYIFIH
  .||...... |||.|.|..  .||.|.. . .   .. ||..||||||.||||. .... ||..      |...  .  .|..| ..||...|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EALYE
 ||.|
falle
0044763 (Phosphotyrosine protein) phosphatases II 1254-1471 6.2e-37 122.3 In-house 2-167 (178) alignment 
Range on Protein: 1254-1471
Range on HMM: 2-167/178.0
YDHSRVILSPMEGLPGSDYTNANYCDGYrkqnAYIATQGPlletmADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQekygfiqvtlldttela
.|..||.||..|||..|||.||.. ...     |.....|     ||......|.  ..||..|.  |....|||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tytvrsfalvknrsmekrevKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERikhekTVDIYGHVTCLRAQ
                     |.... .||||||.    .|.|.  .... ... ||..|||||||||.|. .... |...      ....  .  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEEQYIFIHEAL
|. .|....|. ...|  
Rp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1533-1767 6.9e-36 118.4 In-house 58-284 (290) alignment 
Range on Protein: 1533-1767
Range on HMM: 58-284/290.0
FKNRLLNIQPYEGNRVCLQpiRGVEGsDYINASHIDGYRqrNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARY---Q
 |||  ..   .  || |.   | .| ||. | ...| .    .| |||.|..|. |.|||. ... . |||| .| | |. ||.||.| .        .
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

YFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTkeqfgqEGPISVHCSAGVGRTGVFITLSVVLERMRYE
. |.  ... .  . |.. . | |  .|..  .. ..   ||.. |..|   ..  .  . |.       ||. ||||||.|||| |... | |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLG
  .|. ..|. ||  | . || . ||    .. |..  
keldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1238-1474 1.2e-35 117.8 In-house 31-269 (285) alignment 
Range on Protein: 1238-1474
Range on HMM: 31-269/285.0
NLETNKPKNRYANVIAYDHSRVILSPMEglpgSDYTNANYCDG-YRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ
  |.|   ||||.| . . .||.|   .     ||  |..     . |..||.||||| ||..|||.|.....   ..|.  | |    ||  |.| .  
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

E--KYGFIQVTLLDTTELATY--TVRSFALV--KNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDaGPIVVHCSAGVGRTGAYIVIDS
|  |.|  ..|| .  | |     . .....  .. | |   ... |   |||.  || |  .. .   ||  || .  ||.|||||||||| ... || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidy

MLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEA
   ||  .  ...   |  .|| |   ||.  |..|..  | | 
atirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1240-1403 2.5e-35 116.8 In-house 31-196 (297) alignment 
Range on Protein: 1240-1403
Range on HMM: 31-196/297.0
ETNKPKNRYANVIAYDHSRVILspMEGLPGSDYTNANYCDG--YRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQE
..   |||| ...|.| .|| |  . . ...|| ||.|       ..  || .|||| .|. |||..|.||  ..|||..||.|  | ||  |||  .||
nsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

KY--GFIQVTLLDTTE--LATYTVRSFALVKNrsMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSC
.   | . |  | .|     .  .  . |.     |.| |.  || .|||||||     .  | ..| ||
rlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
PTPc_DSPc_SM00012 1373-1472 7.5e-35 114.7 In-house 2-104 (105) alignment 
Range on Protein: 1373-1472
Range on HMM: 2-104/105.0
VKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDA--GPIVVHCSAGVGRTGAYIVIDSMLERIKHE-KTVDIYGHVTCLRAQRNYMVQTEEQYIFIHE
||....|.||||||||...|.| ..  ||...   .  .|.|||||||||||| ....| .|.....| |.|||.  |  || ||. ||||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALY
|| 
all
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1241-1476 1.6e-34 114.3 In-house 42-272 (288) alignment 
Range on Protein: 1241-1476
Range on HMM: 42-272/288.0
TNKPKNRYANVIAYDHSRVILSpmegLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYG
.|  ..|| |.   | .|| ||         | .||     . ..  | .| ||  |.  .|.|. |.  . |||...| |. . | ..|.|..  ||  
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FIQV-TLLDTTELATYTVRSFALVKNR-SMEKRE-VKQFQFTAWPDHGVPEHATSVLAFISRVKSCNppdaGPIVVHCSAGVGRTGAYIVIDSMLERIKH
. .. |           . . .|...   .|..  ||.  .  |.|.||||   | | .. ..||..     |||||.||||||||. |.|  .|| .. 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

EKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVA
.  . |   .. ||..|   .||| ||...|  ..| ..
ddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1508-1689 1.6e-34 114.1 In-house 11-193 (297) alignment 
Range on Protein: 1508-1689
Range on HMM: 11-193/297.0
NEFKRLaSQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpiRGVEGSDYINASHIDGY--RQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVML
.|   |  ..|..  | ||. ..   |||  .|  .. .|| |.  |.. ..||||| ..      .   || .|||| .| .|||....||.  .|||.
aekdll.ldeargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

SKLREMGREKCHQYWPAERSARY--QYFVVDPMSEYN--MPQYILREFKVTDArdGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQV
.||.| ||.||  |||     |     .||. .|..     . || |...      .|| .|  ||  ||. |||   |    |  ||
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1531-1766 1.2e-33 111.1 In-house 55-289 (305) alignment 
Range on Protein: 1531-1766
Range on HMM: 55-289/305.0
NKFKNRLLNIQPYEGNRVCLQPIRgveGSDYINASHIDGYR-QRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARY-
.. |||  ..   . . | |.       |||| | ..       . .|..|||| .| ..|| |. ...   |||| |  |.|. || ||||| .  .  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

--QYFVVDPMSEYNmPQYILREFKVTD----ARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqfGQEGPISVHCSAGVGRTGVFITLSVV
     ||. .|  . |     | ..|        .|. ..|..|.|.||..|||      ....  .       | . || ||||||.||||  ...  .
lksgivvenvsgsk.pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRY-EGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
||..        | . || || ||   .|.. || | .   |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1562-1756 1.9e-32 107.2 In-house 78-271 (301) alignment 
Range on Protein: 1562-1756
Range on HMM: 78-271/301.0
INASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQ--YFVVDP-MSEYNM-PQYILREFKVTDAR-D
| |  |.   . . .||||||| .|.|||| ||   .   ||||.. .|   |||..| | . | . .   | .    .|. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqegPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQ
 ..||.  .|...|...|||||     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||. |  
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1274-1467 1.5e-31 104.3 In-house 79-273 (301) alignment 
Range on Protein: 1274-1467
Range on HMM: 79-273/301.0
NANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEK--YGFIQVTLLDTTELATYTV--RSFALVK-NRSM
 ||. .   . . .||||||| .|. ||| |.     ..|||...  |..  ||..| |.. .||   |  .... ..  .    .  |.. ..   . .
hanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkf

EKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNppdaGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFI
. | |  .|.. |.|.|||.  . .  ..  ||  .     |||||||||.||. |.|  . .  ... ..|...   .  || .|   |||..|  ..
atrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_CG42327_pd Subfamily CG42327 1241-1402 3.8e-31 102.9 In-house 27-192 (319) alignment 
Range on Protein: 1241-1402
Range on HMM: 27-192/319.0
TNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRK-QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRD----
| |.|.|..||.   ..||.|  .   . . | .|.|  ||.. .| |||.| .| .. .||||.||||.. .|| .|.| |    .| .|.||..    
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

QEKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFtAWPDHGVPEHATSVLAFISRVKS
.. || |.||| .      | . .. | .    | ||.  . .  |.. .|| . ....| . .|.|
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1528-1766 4.5e-31 102.9 In-house 32-270 (285) alignment 
Range on Protein: 1528-1766
Range on HMM: 32-270/285.0
IPANKFKNRLLNIQPYEGNRVCLQPirgvEGSDYINASHIDG-YRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERS-
  ||   ||  ...  |  || |.        ||| || .    .....||.||||| ||  |||.|..... . ..||  | | | |||  |.| .   
yeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

----ARYQYFVvDPMSEYNMPQYILREFKVTDARDGQSRTI--RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfGQEGPISVHCSAGVGRTGVFITL
     .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .| || ||||||||||  |. .
vvkfgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagvgrtatfvgi

SVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
     |.  .  ..|.. |. .|. |   ||.  |. | |   .||.
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1530-1766 1e-30 101.6 In-house 47-287 (305) alignment 
Range on Protein: 1530-1766
Range on HMM: 47-287/305.0
ANKFKNRLLNIQPYEGNRVCLQPirgVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQ
 .. |||  ..   . ||| |..       .|| | ..    . . .| || || .|  ||| | ....   | || .| | | .||..|....     .
qeagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

Y------FVVDPMSEYNMPQY------ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqeGPISVHCSAGVGRTGVFI
.       .|   |  ..         . .   | .   ...| . .. . |||..||| .    .... .   .|      ||| ||||||.||||  .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvv

TLSVVLERMRYEGIVDM-FQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 |  .|...    |..   . .. .| ||   .||..|| | .   |.|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1243-1478 2.9e-29 96.7 In-house 44-279 (312) alignment 
Range on Protein: 1243-1478
Range on HMM: 44-279/312.0
KPKNRYANVIAYDHSRVILSPMEGLpgsdYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPtrdqEKYGFI
|  ||| |.  .|  |  |.  | .    |  ||.     | . ...||||| .| . ||...    . .|.... . |    || .|      .  ||.
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis....divgfv

QV-----TLLDTTE-------LATYTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKScnppDAGPIVVHCSAGVGRTGAYIVIDS
..          ||           | | . .| . . ..  ....|...|||||.|.   . | ..| ||     |  |.. ||||||||||. ..|.|
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalies

MLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASG
|.  ..| .  ..      || .|   |..  ||..   .. | . | 
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1505-1766 4.8e-29 96.3 In-house 20-271 (288) alignment 
Range on Protein: 1505-1766
Range on HMM: 20-271/288.0
GMENEFKRlaSQKAQPSRFVSANIpANKFKNRLLNIQPYEGNRVCLQpirgvEGSD-YINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIV
|.. |..   | .  . . ... | ||  ..|  |.   .  || |.     . .| ||.|  .   . ..  | .| ||  | | .|.|| |..   ||
glkkeyrd..spneasidiidsfi.anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyiv

MLSKLREMGREKCHQYWPAER--SARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRT-IRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQEG
||..| | |.||  .|.| .   .||.. .  .   ...  . ...   .   . |. .  ...  . .|...|||..   .. ..  .         . 
mlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqk

PISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
|| ||.|||||||| .|   ..|| .| .  . . . .. || .|   .||| || . .   ||.|
PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1367-1509 4.9e-28 92.6 In-house 85-228 (440) alignment 
Range on Protein: 1367-1509
Range on HMM: 85-228/440.0
SMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKS-CNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYI
..| | .||... .|||.|||. |  || .|  |.   .    ||..||||||.||||  |..||.|   |.   .||.  . ..| .|  |||| ||| 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIHEALYEAVASGTTEVHARNLYGHIQKLTALEPGETITGMENE
|.|||. |.. .| | .   ..  .....   .|    . ...|
fvheavlegllcgdtliledditerveqiqwpnphtdksplqqe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1283-1468 6.9e-28 92.2 In-house 3-197 (199) alignment 
Range on Protein: 1283-1468
Range on HMM: 3-197/199.0
KQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ--EKYGFIQVTLLDTTELATYTVRSFALVKNRSM--EKREVKQFQF
 |  ||||| || |||||||.||||  .  |||.   .  . .    |||| .    ||| . ||    |  . ||. .. |..| .     ||. ..||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPEHATSVLA-FISR--VKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKT--VDIYGHVTCLRAQRNYMVQTEEQYIFIH
|.| ..  |. |  |     ||   |  .     |..|||| | | || .. .|  .   .  ||  ||..     ||  |  .. . ..| ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1284-1468 1.4e-27 91.2 In-house 3-196 (198) alignment 
Range on Protein: 1284-1468
Range on HMM: 3-196/198.0
QNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQ--EKYGFIQVTLLDTTELATYTVRSFALVKNRSM--EKREVKQFQFT
|  ||||| || ||.||||.||||  .  |||.   .  . .    |||| .    ||| . ||    |  . ||. .. |..| .     ||. ..|||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPEHATSVLA-FISR--VKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKT--VDIYGHVTCLRAQRNYMVQTEEQYIFIH
.| ..  |. |  |     ||   |  .     |..|||| | | || .. .|  .   .  ||  ||..     ||  |  .. . ..| ||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_CG42327_pd Subfamily CG42327 1529-1694 2.9e-27 90.2 In-house 26-195 (319) alignment 
Range on Protein: 1529-1694
Range on HMM: 26-195/319.0
PANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQ-RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERS--
.. | |.|..|. |    || || |   . . |..||.. ||.. .| |||.| .| ... ||||..|||.| .|| |..| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFtDWPEQGVPKSGEGFIDFIGQVHKTKE
    |  . |         .|..  . .    . .|| .  . . .|.| .|| . . .|  . .|... .
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1503-1760 7.7e-27 88.7 In-house 26-284 (310) alignment 
Range on Protein: 1503-1760
Range on HMM: 26-284/310.0
ITGMENEFKRLASQKAqPSrFVSANIPANKFKNRLLNIQPYEGNRVCLQpIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTII
| |. .....| ...  .| .       .  |||  ..   .  || |. |      ||| | ..     |...| .||||  |  |||||.... .  |
ieglvkqyrkldakqd.ss.ltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMLSKLREMGREKCHQYWPAER-SARYQYFVVDPMSEYNMpQYILREFKVTDA-----RDGQSRTIR-----QFQFTDWPEQGVPKSGegfIDFIGQVHK
..| |  | || ||  |||.   .  |    |  .||    .. . .. ||        | |   ..       .. .||..|||         . |   
lllckvgeegrpkcvgywpslgvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrll

TkeQfGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYH
.  |  . ||  ||||||..|..| ..| . .....    ||. . .  |. .|   .||| || .  .
a..q.vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_egg_pd Subfamily egg 1232-1471 8.6e-27 88.6 In-house 30-266 (307) alignment 
Range on Protein: 1232-1471
Range on HMM: 30-266/307.0
FTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRvkCDQYW
 .  ..  . |. | |   |   | ||| |   .|    |.  ||. .|    | .| .| || .|. ||||||.... . |||.|   | .|  |. ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser..ceyyw

PTRDQEKYGF----IQVTLLDTTE--LATYTVRSFALVKNRsMEKREVKQFQFtawpDHGVPEHATSVLAFISRVKSCnppdAGPIVVHCSAGVGRTGAY
|  ...   .    .... |.  .     ..|  . ||     |.| .. .|     |     .  | |  . ...      . |.||..  || .... 
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwqg....dvnnssdvysplrvlrklrnl....skpvvvqdilGvskaatl

IVIDSMLERIKHEKT--VDIYGHVTCLRAQRNYMVQTEEQYIFIHEAL
. |.  |  .    .    .   |  || .|.. |..  .|.|..  .
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
0048076 (Phosphotyrosine protein) phosphatases II 1345-1471 1e-26 88.7 In-house 18-139 (145) alignment 
Range on Protein: 1345-1471
Range on HMM: 18-139/145.0
TLLDTTELATYTVRS-FALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDaGPIVVHCSAGVGRTGAYIVIDSMLErikheKTVDI
| ||  .|. . ..  . |  ... ..|.. |.... |||||||. .  .|.|.  .... . . ||..|||||||||||...... ||.     . |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

YGHVTCLRAQRNYMVQTEEQYIFIHEAL
.  .  .|.|| ..|....|..|..|..
eealelvrsqrpgavpnpgqlrflyefe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1573-1760 1.8e-26 87.5 In-house 4-198 (199) alignment 
Range on Protein: 1573-1760
Range on HMM: 4-198/199.0
RNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSAR--YQYFVVDPMSEYNMPQYILREFKVTDAR--DGQSRTIRQFQFT
.  ||||| || ||  |||.|.||  |  |||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| | ..|||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPEQGVPKSGeGFIDFIG---QVHKTKEQfGQEGPISVHCSAGVGRTGVFITLSVVLER--MRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYH
 | |.  |.    |. |.    .| |  ||  .. |. |||| | | ||||..| . .         .||.|.  | ||  |  .. . ..|.| | 
swkekttpnva.lfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1574-1760 2e-26 87.4 In-house 4-197 (198) alignment 
Range on Protein: 1574-1760
Range on HMM: 4-197/198.0
NAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSAR--YQYFVVDPMSEYNMPQYILREFKVTDAR--DGQSRTIRQFQFTD
  ||||| || ||  |||.|.||  |  |||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| | ..||| 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEQGVPKSGeGFIDFIG---QVHKTKEQfGQEGPISVHCSAGVGRTGVFITLSVVLER--MRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYH
| |.  |.    |. |.    .| |  ||  .. |. |||| | | ||||..| . .         .||.|.  | ||  |  .. . ..|.| | 
wkekttpnva.lfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048179 (Phosphotyrosine protein) phosphatases II 1355-1469 7e-26 86.1 In-house 31-139 (144) alignment 
Range on Protein: 1355-1469
Range on HMM: 31-139/144.0
YTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDaGPIVVHCSAGVGRTGAYIVIDSMLerikHEKtVDIYGHVTCLRAQR
.|| ...       ..||. |.... |||||||.... .|.|.  .... ... ||..|||||||||||...... |.    ... ....  .  .|..|
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

NYMVQTEEQYIFIHE
 ..|....|..|..|
pgavpnpgqlrfLle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1283-1466 1.4e-25 84.8 In-house 33-212 (255) alignment 
Range on Protein: 1283-1466
Range on HMM: 33-212/255.0
KQNAYIAtqgplleTMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRSM--EKREVKQFQFTA
..| |.        |.. |....  ..|...||.. ..| ...||..|.|.  .||  . .|..  |   |   .|   .. . .   . ..|| .... 
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDHGVPEHATSVLAFISRVKscnppDAGPIVVHCSAGVGRTGAYIVIDSMLE----RIKHEKTVDI--YGHVTCLRAQRNYMVQTEEQYIF
|...  || |  .|  .  |.     |. ..|||||.|.||. |.......       ..  .||..     .. || .|.  ..|  |  |
WieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
0048076 (Phosphotyrosine protein) phosphatases II 1650-1765 7.7e-25 82.7 In-house 35-142 (145) alignment 
Range on Protein: 1650-1765
Range on HMM: 35-142/145.0
KVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgqEGPISVHCSAGVGRTGVFItlsvVLERMRYEGiVDMFQTVKMLRTQRPAMV
 .|. ... .|.. |.....||  ||| . | ...|. ....  ..   .||. |||||||||||...    ..  |...| |.........|.||| .|
nltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgav

QTEDQYQFCYHAALEY
....|..|.| . ||.
pnpgqlrflyefelel
subfamily_hpo-7_pd Subfamily hpo-7 1283-1467 4e-24 79.9 In-house 36-219 (263) alignment 
Range on Protein: 1283-1467
Range on HMM: 36-219/263.0
KQNAYIAtqgpLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKNRS--MEKREVKQFQFTA
..| |.     |..|.. |....  ..|...||..  .| ...||..|.|.   ||  . .|..  |       ...  |... .   . ..||..... 
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WPDHGVPEHATSVLAFISRVKscnppDAGPIVVHCSAGVGRTGAYIVIDSM----LERIKHEKTVDI--YGHVTCLRAQRNYMVQTEEQYIFI
|...  || | ..|  .  ..     .  ..|||||.|.||. |. |....    .  ..  .||..     .. || .|.  ..|  |  | 
Wiekndpelareilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs
subfamily_egg_pd Subfamily egg 1502-1763 5.2e-24 79.5 In-house 12-267 (307) alignment 
Range on Protein: 1502-1763
Range on HMM: 12-267/307.0
TITGMENEFKRLaSQKAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTI
 . ..|  .. |  . ..   .  |    |. | |   ..  .  || |.  ||    |.| | ...|    | .| .| || .| .|||||.....   
ivqelerrlevl.eesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqy

IVMLSKLREMgrEKCHQYWPAERSARYQY----FVVDPMSEYNMPQYIlreFKVTDARD-GQSrtiRQFQFTDWPEQGVPKSGEGFIDFigQVHKTKEQF
||||.  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .|.. .  .  .| .   . 
ivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrnl

GQegPISVHCSAGVGRTGVFITLSVVLERMRYEGIV--DMFQTVKMLRTQRPAMVQTEDQYQFCYHAAL
 .  |. |..  || ........ . |  .    |.   . ..|..|| .|.  |..  .| | |   |
sk..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048179 (Phosphotyrosine protein) phosphatases II 1652-1760 6.1e-23 76.6 In-house 48-139 (144) alignment 
Range on Protein: 1652-1760
Range on HMM: 48-139/144.0
TdardgqsrtIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQEGPISVHCSAGVGRTGVFITLSvvleRMRYEGiVDMFQTVKMLRTQRPAMVQT
.         . |.....||  ||| . | ...|.  ...  |   ..||. |||||||||||.....     .|...| ..........|..|| .|..
e.........giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpn

EDQYQFCYH
..|..|.. 
pgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1658-1767 6.8e-23 75.7 In-house 87-195 (440) alignment 
Range on Protein: 1658-1767
Range on HMM: 87-195/440.0
QSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQF
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|.|  .. .| .|| |||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYHAALEYLG
 ..| || | 
vheavlegll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1244-1338 6.9e-23 75.9 In-house 49-157 (350) alignment 
Range on Protein: 1244-1338
Range on HMM: 49-157/350.0
PKNRYANVIAYDHSRVILS----P----MEGLPGSDYTNANYCDGY---RKQN---AYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQ
 |||| |.. |.||||.|     .       | ..|| ||||        ..|    |||||.|| .|. ||.... .   . |...|.. | |. ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPTRDQEK
||.  . ..
YWqegsydd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1533-1770 1.2e-22 75.0 In-house 43-280 (312) alignment 
Range on Protein: 1533-1770
Range on HMM: 43-280/312.0
F--KNRLLNIQPYEGNRVCLQpirGVEgSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPA-------E
|   ||  ||| ..  |  |    | |   || |  .    . . ...||||| .|.  ||..     || |..|. . | | ||| .|          |
fkdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

RSARYQYFVVD-PMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqegPISVHCSAGVGRTGVFITLSVV
    |  .. .  .      .   | .||     ||   . ..|.. ||..|.| | .    ..  |.| |       |.  |||||||||| .. .  .
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesm

LERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYLGSFD
.  .|.    .. ..  .|| .|   |..  || .. .. ||.| |  
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1290-1468 2.9e-22 73.5 In-house 96-281 (302) alignment 
Range on Protein: 1290-1468
Range on HMM: 96-281/302.0
TQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPTRDQEKYGFIQVTLL--D-TTELATYTVRS-FAL-------VKNRSMEKREVKQFQF
   |  .|.  .| .. . ..  .| .... | .  || .|. .. ...  | . |.   .  |.|. .| .  | |        | ..  |. |. ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TAWPDHGVPEHATSVLAFIsrvKSCNPPDaGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIH
.|||||| |..| . |  .   | |.      ..|||||||||||. . |   ..  ...|. |.   |. .|. |   ||.|.| |.. 
sawpdhGapkeaytaldil...kfcesyk.knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1532-1622 1.2e-21 71.8 In-house 48-152 (350) alignment 
Range on Protein: 1532-1622
Range on HMM: 48-152/350.0
KFKNRLLNIQPYEGNRVCLQ----P----IRGVEGSDYINASHIDGY----RQRNA--YIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCH
  |||  || ||| .|| |.    .       ....|||||...       ..     |||||.|| .| .||.... . . ..|..|... |...|||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPA
.||. 
rYWqe
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1411-1477 2.3e-20 66.8 In-house 1-67 (69) alignment 
Range on Protein: 1411-1477
Range on HMM: 1-67/69.0
IVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVAS
.|||||.| ||||..| |   . ||| || |||.  |  .|  |  ||  | .|||||.|| ||.  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1214-1475 3.1e-20 67.0 In-house 19-279 (303) alignment 
Range on Protein: 1214-1475
Range on HMM: 19-279/303.0
NDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSpmeglpGSDYTNANYCDGYRKQNAyIATQGPLLETMADFWRMVWEQRTNTI
.|| .  .|.| .      .  . .. .|  |||...||  |||.| ||       | |  |.| .   ...| | || ||  | ||||.|. ||. . .
edaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcv

VMMTKLEERNRVKCDQYWPTR-DQEKY--GFIQVTLLDTTELATYTVRSFALVKNRSMeKREVKQFQFTAWPDHGVPEH-ATSVLAFISRVKSC--NPPD
...    | ...  |  .|   |  |.   .|.|  .   ||.   |     | | .  |  ..  .. |||   .| . .  ..  | ...|   .  |
lllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdy.ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd

AGPIVVHCSAGVGRTGAYIVIDSMLERIKHE-KTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
. | |    .|.||.|.. ....    .. |  ..|.   .  .|  | . ||   |. ...  | | |
stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1503-1765 8e-20 65.4 In-house 25-284 (302) alignment 
Range on Protein: 1503-1765
Range on HMM: 25-284/302.0
ITGMENEFKRLASQKAQPSRfvSANIPANKFKNRLLNIQPYEGNRVCLQpirgVEGSDYINASHIDGYRQRNAYIATQGPLAETT---EDFWRMLWEQNS
 . ...|||.....|..  .       .|  ||.  ... .. |.| |.     |  .|.|||...    ..  | .| |  ...   |.|||| .... 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

TIIVMLSKLREMGReKCHQYWP--AERSARYQYFVVDPMSEYNMPQYIlREFKVTDARDGQSRTI--RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
. .|.| .  |. .   ....|  ..    |. . |      .. .    .. .    .| | ..      .| |... ||..    |  . .|.. |..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkik

fgQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
   . .. .    |.|| |.|.|| |..|..  .  . . ..|| .|.|||..|.. .|| . | |.| |
..adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1412-1478 1.4e-19 64.2 In-house 1-67 (69) alignment 
Range on Protein: 1412-1478
Range on HMM: 1-67/69.0
VVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAVASG
|||||.| ||||..| |   . ||| || |||.  |  .|  |  ||  |..|.|||.|| ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
fn3 Fibronectin type III domain 444-532 1.8e-18 59.7 Pfam-A 2-85 (85) alignment 
Range on Protein: 444-532
Range on HMM: 2-85/85.0
PPQEVSGTVLSSTSIEVRWSPPPleDQNGDITGYKIIYRKMSLVStnnPEMNVPVEADVRSYILEALRKYTLYDIRVVACTAIGDGPPS
.|. .| .  .|||....||||.  |..|.||||.. ||...  .   .. .. |... .|..|. |. .| | .|| |... | ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1574-1766 1.1e-17 59.0 In-house 35-221 (255) alignment 
Range on Protein: 1574-1766
Range on HMM: 35-221/255.0
NAYIAtqgplaeTTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARD--GQSRTIRQFQFTDWP
| |.        | . |....  .... .|||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .|.. .... |.
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWi

EQGVPKSGEGFIDFIGQVHKTKeqfgqegPISVHCSAGVGRTGVFITLSVVLERM----R--YEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
|.  |.  .     .  |...|       .. ||||.|.||.  |.   .|  .|    .    . .|  . .. || .|.. ..|  |  |.    |..
eknaPelareilnilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

L
.
v
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1688-1764 4.2e-17 56.9 In-house 217-293 (297) alignment 
Range on Protein: 1688-1764
Range on HMM: 217-293/297.0
QVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALE
|.   . .  .. .. |||||||||.|| .   |.|...| . | |.   ...|| ||. .||| .|....|.|.|.
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1239-1470 7.3e-17 56.4 In-house 16-254 (290) alignment 
Range on Protein: 1239-1470
Range on HMM: 16-254/290.0
LETNKPKNRYANVIAyDHSRVILSPMEGLPGSDYTNANYCDgYRKQNAYIATQGPLLET-------MADFWRMVWEQRTNTIVMMTKLEERNRV----KC
.. .. ..|... ..  ..||.|        .||  ||.   . .  . |.|| |. ..       . .|| |. . . . .||. . ||...      |
vkkhemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaC

DQYWPTRDQEKYGFIQVTL--LDTTELATYTVRSFaLVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKsCNppdAGPIVVHCSAGVGRTGAY
 .| |..  |.  |  .|.   .  .     .|   .||    |.  |.  ..  | .  |.|.  ..|. |. || ..     |..|||  |. |  | 
akYvpesvgeelkfkgltvkCkskekeddvetRel.vvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAal

IVIDSMLERIK-HEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEA
  |.     |   .. | .   .  || ||. ........ |.  .
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1198-1292 1.5e-16 54.4 In-house 4-95 (95) alignment 
Range on Protein: 1198-1292
Range on HMM: 4-95/95.0
PIPVSQFQEHIERLKGNDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEglpGSDYTNANYCDGYRKQNAYIATQG
|| || |. |.  .. |    | .|. ||      ..     |.| ||||. |.. || .||.|.       ||| || . ||| ..|.|||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1662-1765 2.1e-16 54.6 In-house 217-343 (350) alignment 
Range on Protein: 1662-1765
Range on HMM: 217-343/350.0
IRQFQFTDWPEQGVPKSGEGFIDFIG--------QVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLE-RMR-------------YEGIVD-MFQTV
. |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.                    . | ....|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KMLRTQRPAMVQTEDQYQFCYHAALEY
. || ||  |||. ||. |.|.|.| |
nelrkqrismvqnldqfifiYeallfy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1240-1471 2.3e-16 54.1 In-house 49-281 (302) alignment 
Range on Protein: 1240-1471
Range on HMM: 49-281/302.0
ETNKPKNRYANVIAYDHSRVILSPMEglpgSDYTNANYCDGYRKQNAYIATQGPLLETM---ADFWRMVWEQRTNTIVMMTKLEERNRvKCDQYWP--TR
  |  ||.  .| ..|. .|.|.  .     .| ||   .    ..  | .| | ...    ..|||||....  ..|.. . || ..   ....|  . 
kknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DQEKYGFIQVTLL--DTTELATyTVRSFALVKNRSMEKREVKQFQFTAWPDHGVPEHATSVLAFISRVKSCNPPDAGPIVVHCSAGVGRTGAYIVIDSML
| ..|| . |     . .| .. |  .  .. .   .   ..   .| |... ||.. ... . .  |   . .   ..|.    |.|| || ..    .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

ERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEAL
|.....| . |   |. .|.||  .|.. .||.... ||
eklqkgkepnikeivksiRsqRpravdslkQyvslyial
fn3 Fibronectin type III domain 747-829 2.4e-16 52.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 747-829
Range on HMM: 2-85/85.0
SPMNVTASPLSSSSISVSWDPPLeeERNGLILKYTIRYYSSAM---PTELTNRTTETDIVLTSLVPNTAYSVEVRAHTSVGPGPYS
.| |...|. .|.|...||.||   ...| | .|...| ..     ..| |.  |.|  .|| | |.| |...|.|.. .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1580-1756 2.8e-16 53.8 In-house 97-278 (302) alignment 
Range on Protein: 1580-1756
Range on HMM: 97-278/302.0
QGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSA--RYQYFVVDPMS-EYNMPQYI--------LREFKVTDARDGQSRTIRQFQFT
  |  .|.| .| .. . | .|.| |... | . .|| .|.  .     ... . |  .| . .. ..           |.| .  .. . .|.  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DWPEQGVPKSGEGFIDFIgqvhKTKEQFGQEgpISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQ
 ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . . |. . |. .|. |   ||.|.|  
awpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_CG42327_pd Subfamily CG42327 1407-1473 8.5e-16 52.5 In-house 246-313 (319) alignment 
Range on Protein: 1407-1473
Range on HMM: 246-313/319.0
DAGPIVVHCSAGVGRTGAYIVIDSMLERIKHE-KTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
. ||.||||| ||||||  |  |  ......  ..|||   |  .| .|   |.| ||| ||.  |.|
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1704-1765 1.1e-15 51.7 In-house 2-63 (69) alignment 
Range on Protein: 1704-1765
Range on HMM: 2-63/69.0
VHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
||||.| |||| ||.. | . |.. | .||.|  |. .|  || ||  |..| | . |  | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1368-1472 1.4e-15 51.8 In-house 212-341 (350) alignment 
Range on Protein: 1368-1472
Range on HMM: 212-341/350.0
MEKREVKQFQFTAWPDHGVPEHATSVLAFIS-------RV---KSCNPPDAGPIVVHCSAGVGRTGAYIVIDSMLE------RI----KH----EKTVD-
 .  .| |.|.  |.| ..  .  |.|  .             .  .   . ||.||||||||||| .. .||.|.       .    ..     || | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IYGHVTCLRAQRNYMVQTEEQYIFIHEALY
|   |  || ||  |||. .|.|||.||| 
isiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1703-1765 1.4e-15 51.4 In-house 2-64 (69) alignment 
Range on Protein: 1703-1765
Range on HMM: 2-64/69.0
SVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
 ||||.| |||| ||.. | . |.. | .||.|  |. .|  || ||  | .| | . |  | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1517-1623 1.5e-15 51.5 In-house 82-181 (244) alignment 
Range on Protein: 1517-1623
Range on HMM: 82-181/244.0
KAQPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpiRGVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREmgrekC
. .|| .  |  | | .|||     |.. ||| |   .|  |  ||||| .    .   || || |||.|. |||.|. |.   ..|.|  . |      
rpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....e

HQYWPAE
 .|||  
deywpds
subfamily_CG42327_pd Subfamily CG42327 1698-1765 1.5e-15 51.7 In-house 246-314 (319) alignment 
Range on Protein: 1698-1765
Range on HMM: 246-314/319.0
QEGPISVHCSAGVGRTGVFITLSVVLERMRYE-GIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAALEY
. ||. |||| ||||||. |.  . ....      ||. |.|  .| .|   |.| .||.| |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1543-1760 4.1e-15 50.7 In-house 30-253 (290) alignment 
Range on Protein: 1543-1760
Range on HMM: 30-253/290.0
YEGNRVCLQPIRGVEGSDYINASHIDgYRQRNAYIATQGPLAET-------TEDFWRMLWEQNSTIIVMLSKLREMGRE----KCHQYWPAERS--ARYQ
 | .|| |.       .||| |...  . .  . |.|| |....        |.|| |  . ... .||| .  |  ..     | .| | .     ...
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

YFVVDPMSEYNMPQYILREFKVTdARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQEGPISVHCSAGVGRTGVFITLSVVLERMR-Y
 . |   |  .  . . ||  |.   |..  |.   .. .| .  |...   ... | .|..      .. |. |||  |. |  .. .. .    .   
gltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilgyQkiaet

EGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYH
.| | . . .|.|| ||  ..... .. |   
sgsvkledvlkalrkqralaitsalelafvda
I-set Immunoglobulin I-set domain 70-148 4.3e-15 47.3 Pfam-A 1-82 (90) alignment 
Range on Protein: 70-148
Range on HMM: 1-82/90.0
PEITSNPrRYMVVENNRPATIYCGATGNPEPEILWFKEFVPIEANDRISMTDSG----LQFSRAQLSDQGRYECAAKNSLGTR
|..|  . . ..|. .  ... | ..|.|||.. |.|.  ... ..|...| ..    | .|... ||.|.|.| |.||.|..
pkftqkl.kdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagka
fn3 Fibronectin type III domain 547-636 4.3e-15 48.8 Pfam-A 2-84 (85) alignment 
Range on Protein: 547-636
Range on HMM: 2-84/85.0
PPRKVRVRVHNSTTIRVQWQAPDpdLQNGEIRGYRIDYQTVTEEGdpvgsPQVLFINQPDLRVAVLSDLLPKTFYSIEIAAFTVRGDGIR
.|. ..|.  .||.....|..|.   ..|.| ||...|.......     . . | . .. . ..|..| | | |.....| .  | | .
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_hpo-7_pd Subfamily hpo-7 1572-1765 6.8e-15 49.7 In-house 36-226 (263) alignment 
Range on Protein: 1572-1765
Range on HMM: 36-226/263.0
QRNAYIAtqgpLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARD--GQSRTIRQFQFTD
..| |.     | .| . |....  .... .|||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .|....... 
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WPEQGVPKSGEGFIDFIGQVHKTKEqfgqegpISVHCSAGVGRTGVFITLSVVLERM----R--YEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAAL
|.|.  |.  .  .  .  . . |.       . ||||.|.||.  |    .|  .|    .    . .|  . .. || .|.. ..|  |  |     |
Wiekndpelareilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

EY
..
df
fn3 Fibronectin type III domain 253-335 3.7e-14 45.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 253-335
Range on HMM: 2-85/85.0
VPNSPVVTGYTSSSLTVEWSTLS--SDTVTSHVLEYKRSRSGGSFTEMEIPSPQDtSFTIEGLLPYTEYAVRLLAVNSIGRSNPS
 |  . |.. ||.|||..||  .  ....|.  .||. ...|.  .|  .|.... |.|..|| |.||| .|. |||  | . .|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1241-1333 6e-14 46.2 In-house 33-124 (332) alignment 
Range on Protein: 1241-1333
Range on HMM: 33-124/332.0
TNKPKNRYANVIAYDHSRVILSPMEGlpGSDYTNANYCDGYRKQNAYIATQGPLLE-TMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWPT
 |   ||   . ..||||| |.| .|    |. ||.. ||| |..||| .| |. . |   ||||| |.. . |...  ..|... |.      
nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisd
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1506-1581 7.7e-14 45.7 In-house 25-95 (95) alignment 
Range on Protein: 1506-1581
Range on HMM: 25-95/95.0
MENEFKRLASQKAQPsrFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRgveGSDYINASHIDGYRQRNAYIATQG
..|||| ..     |  .      ||  |||.||| ||.  ||.|   |    ||||||  .||| ..|.|||.||
fdnefksismtsgap..ytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_eak_pd Subfamily eak 1248-1400 9.2e-14 45.6 In-house 57-207 (332) alignment 
Range on Protein: 1248-1400
Range on HMM: 57-207/332.0
YANVIAYDHSRVILSPMEgLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKCDQYWP--TRDQEKYGFIQVT
  ... ||.  | |..   |    | ||   .     . || |  .  . .  ||.|| ||.. .||.. .  | .  | |.|.|  ||.. |.|...|.
vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

LLDTTELATYTVRSFALVKnrSMEKREVKQFQFTAWPDHGVPEHaTSVLAFISRV
  .  . . . .| . | |    |  .|. ...  | .  .|      ||.   .
rkefvkrniletrllelsk..GnethrvlhykvfGwtettlpky.edflalrkvm
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1520-1763 3.4e-13 43.9 In-house 36-276 (303) alignment 
Range on Protein: 1520-1763
Range on HMM: 36-276/303.0
PSRFVSANIPANKFKNRLLNIQPYEGNRVCLQpirgveGSDYINASHIDGYRQRNAyIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQY
| .    ..  |  |||. ..   .  .| |        | || ||...   ...| | || ||. |. |||.|. ||.   ...|    |. .   .  
ppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPAERSA-RY--QYFVVDPMSEYNMPQyiLREFKVTDARDGQSRT-IRQFQFTDWPEQGVPKSG-EGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTG
.| ..   ..  ..  |  . . .. .     .||    .|. .. .   .. .|| . .|  |   |.  | |.     .. .  |      .|.||.|
fprnqdflkfeersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

VFITLSVVLERMRY-EGIVDMFQTVKMLRTQRPAMVQTEDQYQFCYHAAL
 |  .      .   .  .|. . ....|  |   ||   |. . |    
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_eak_pd Subfamily eak 1529-1687 4.5e-13 43.3 In-house 49-205 (332) alignment 
Range on Protein: 1529-1687
Range on HMM: 49-205/332.0
PANKFKNRLLNIQPYEGNRVCLQPIRgVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKCHQYWPAERSARY
  .. .  ...| ||. . | | . .  .   ||||| ..     . || |  .  .    ||.|. ||.|  ||.| .  |.. ||  .|.| .    .
rleavnrnvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

QYFVVDPMS-EYnMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSgEGFIDFIG
.. ..|    |. . . ||.  ..   .  ..  .  ...  | |  .||  | |. .  
kfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflalrk
fn3 Fibronectin type III domain 348-429 5.7e-13 42.0 Pfam-A 1-85 (85) alignment 
Range on Protein: 348-429
Range on HMM: 1-85/85.0
SQPEQFEGVAISASQIRLTWMMR-DTEPQIIRYELYYNVS-TNDNDMHKTITPTT-DYVLDNLRPNTLYHIRLAARSETGEGASS
|.||..   ........|.|    | . .| .||. |  . ... . ..|...||  ..| .|.|.| |..|..|... ||| .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1406-1473 6.4e-13 43.2 In-house 226-293 (297) alignment 
Range on Protein: 1406-1473
Range on HMM: 226-293/297.0
PDAGPIVVHCSAGVGRTGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYE
|   ...|||||||||.|  .  | .|.......  |.   .. || ||  .||| ||. ....|  .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
JmjC JmjC domain, hydroxylase 1-32 6.6e-13 36.4 Pfam-A 83-114 (114) alignment 
Range on Protein: 1-32
Range on HMM: 83-114/114.0
ITQEQGEFMVTFPFGYHSGFNHGYNCAESTNF
..|..|||...|| .|||.||.|.|.||..||
fvqkpgefVfvfpgayHsvfnlgfniaeavnf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1244-1350 7.9e-13 42.4 In-house 50-169 (349) alignment 
Range on Protein: 1244-1350
Range on HMM: 50-169/349.0
PKNRYANVIAYDHSRVILSP--------------MEGLPGSDYTNANYCDGY--RKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERNRVKC
 |||| ... |.||||.|                 ..    || ||||        .. ||||| ||  |. ||....  .. . .. ... .| .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWptrDQEKYGFIQVTLLDTT
|.||   .. .|  |.| | .. 
diyw...qelsysnitvklqnss
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1279-1335 1e-12 42.1 In-house 230-283 (440) alignment 
Range on Protein: 1279-1335
Range on HMM: 230-283/440.0
DGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERnrvKCDQYWPTRD
.|| |.||.|||| ||  |. ||||.| . |  ||.|. .|...    |  |||   
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt
fn3 Fibronectin type III domain 652-731 8e-12 38.3 Pfam-A 3-83 (85) alignment 
Range on Protein: 652-731
Range on HMM: 3-83/85.0
PVAFRVENNLDDTYTATWSPPVETHGDLVTYRLSYGPE-SGR-PLYLDLRPSEFqSYTFDDLRLGTRYEFKLTASNEEGNSN
|  ..|... ... | .|||| . .|... |.. | .. .|. .   .. ...  |.|. .|. ||.|||...| |..|.. 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1567-1647 1.5e-11 38.3 In-house 229-307 (440) alignment 
Range on Protein: 1567-1647
Range on HMM: 229-307/440.0
IDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREmgrEKCHQYWPAE-RSARYQYFVVDPMSEYNMPQYILR
..|| ..||.|||| ||  |  ||||.. . . . |.|| .| .     |  ||| . ||  .  | |      || .  .|
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1197-1280 3.3e-11 37.2 In-house 4-85 (440) alignment 
Range on Protein: 1197-1280
Range on HMM: 4-85/440.0
PPIPVSQFQEHIERLKgnDAMLFSQEYESIEPGQQFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNANYCDG
 || |..| ....  .   .  | .|.  .  | .   | ..|  || |||| |..|||||||.|  ..|.| ||| || | .|
rpiivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1266-1386 5e-11 37.0 In-house 9-126 (130) alignment 
Range on Protein: 1266-1386
Range on HMM: 9-126/130.0
GLPGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERnrvkcDQYWPTRDQEKYG--FIQVTLLDTTELATytVRSFALV
 |.| .| ||..     . . |. || || .|  |||.|. |.  | .|..  .||      |.|||  .  ..    | ||| |  |     ...  | 
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn..ikasnle

KNRSMEK--REVKQFQFTAWPDHGV
 .. . .  . .  || . ||  | 
iesdlneshqaltmfqisnwpsdgt
I-set Immunoglobulin I-set domain 164-247 5.7e-11 34.1 Pfam-A 1-90 (90) alignment 
Range on Protein: 164-247
Range on HMM: 1-90/90.0
PRFTILPENQEVVPGGSVNLTCAAYGSPMPRVRWMKAGMDLDDMDDLPIGRNV----LQLRDIY--ESANYTCVATSLLGTIDTSARVTV
|.||. ....||  | ||.|.| . |.| |.|.|.| | .|   ... .  .     | ....   .. .|||.||  .|.  ..|...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1694-1766 7.2e-11 36.0 In-house 260-344 (349) alignment 
Range on Protein: 1694-1766
Range on HMM: 260-344/349.0
EQFGQEGPISVHCSAGVGRTGVFITLSVVLE----------RMRYEGIV-D-MFQTVKMLRTQRPAMVQTEDQYQFCYHAALEYL
 .  |  .. |||||| |||||..|| ..|.          .. .. .  | .. .|  || || .|||   |. ..|.| |.|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1285-1386 1.7e-10 34.9 In-house 137-235 (244) alignment 
Range on Protein: 1285-1386
Range on HMM: 137-235/244.0
NAYIATQGPLLETMADFWRMVWEQRTNTIVMMTKLEERnrvkcDQYWPTRDQ-EKYG-FIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWP
  || || || .|  |||.|. |.  | .|..  .||      |.|||  .  | |   | ||| |  |.       . .  .    .. .  || . ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV
  | 
sdgt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1532-1615 2.3e-10 34.5 In-house 35-117 (332) alignment 
Range on Protein: 1532-1615
Range on HMM: 35-117/332.0
KFKNRLLNIQPYEGNRVCLQPIRGVEgsDYINASHIDGYRQRNAYIATQGPLAETTED-FWRMLWEQNSTIIVMLSKLREMGREK
   ||.  .  .. .|| | |  | .  |. ||| .||| ...||| .| |. . ||  ||||. |.. ..|...  . |  . |
mdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1555-1675 4.2e-10 34.0 In-house 9-126 (130) alignment 
Range on Protein: 1555-1675
Range on HMM: 9-126/130.0
GVEGSDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREmgrekCHQYWPAERSAR-YQYFVVDPMSEYNMPQYILREF-KVT
 ..| .||||| .    . . |. || |||.|. |||.|. |.   ..|.|  . |       .|||       |.  ..  ... .  ..|  .. .. 
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdefknikasnleie

DARDGQSRTIRQFQFTDWPEQGV
.      ...  || ..|| .| 
sdlneshqaltmfqisnwpsdgt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1506-1570 7.1e-10 32.8 In-house 24-86 (440) alignment 
Range on Protein: 1506-1570
Range on HMM: 24-86/440.0
MENEFKRLASQKAQPSRFvsANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINASHIDGY
.|.|.  | |  .|||    |..| || |||  ||  |. .|| |. ..||  |||||||.|.| 
fedewsllpsglsqpsdi..aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_PTPDC1_pd Subfamily PTPDC1 1689-1759 7.9e-10 33.5 In-house 104-169 (182) alignment 
Range on Protein: 1689-1759
Range on HMM: 104-169/182.0
VHKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVlermrYEGIVDMFQTVKMLRTQRPAMVQTEDQYQFCY
. |  ..  ||| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .| ... 
ivkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1533-1621 1.1e-09 32.1 In-house 50-154 (349) alignment 
Range on Protein: 1533-1621
Range on HMM: 50-154/349.0
FKNRLLNIQPYEGNRVCL----QPIRGVEGS----------DYINASHIDGY--RQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVMLSKLREMGREKC
 |||  .| |||  || |    .. .... |          ||||| ..        . ||||| ||  | .||....  ..  ... |..  | . |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWP
..|| 
diywq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1372-1472 1.5e-09 31.6 In-house 219-341 (349) alignment 
Range on Protein: 1372-1472
Range on HMM: 219-341/349.0
EVKQFQFTAWPDHGVPEHATSVLAFISrVKS-----------CNPPDAGPIVVHCSAGVGRTGAYIVIDSMLE----------RIKH-EKTVD-IYGHVT
|. |.|.  |.| ..     |.|  .  ||.            .  .  ...|||||| |||| .. .|..|.          .||   .. | |.  | 
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

CLRAQRNYMVQTEEQYIFIHEALY
 || ||  |||   |.|.|.||| 
elrkqrismvqnlaqfiaiyealL
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1519-1604 1.9e-09 31.5 In-house 25-115 (347) alignment 
Range on Protein: 1519-1604
Range on HMM: 25-115/347.0
QPSRFVSANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEG-----SDYINASHIDGYRQRNAYIATQGPLAETTEDFWRMLWEQNSTIIVM
 ||.| |..   .  |||  . .  .  || | | .   .       |||||||     .. || || || .|  |||.|.   . | .| 
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
Ig_3 Immunoglobulin domain 70-143 2e-09 29.5 Pfam-A 2-75 (75) alignment 
Range on Protein: 70-143
Range on HMM: 2-75/75.0
PEITSNPRRYMVVENNrpATIYCGATGNP-EPEILWF-KEFVPIEANDRISMTDSGLQFSRAQLSDQGRYECAAKN
|.|...|. ..... |   |. | |.|.| .| | |  ..   .. ... | ..| | .| .. .| | |.| |.|
Pvisvspsptvtsggn..vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 70-146 4.2e-09 28.3 Pfam-A 2-69 (80) alignment 
Range on Protein: 70-146
Range on HMM: 2-69/80.0
PEITSNPrryMVVENNRPATIYCGATGNPEPEILWFKEFVPIEANDRIsmtdsgLQFSRAQLSDQGRYECAAKNSLG
| ....|    ||. . . |. | |.|||.|.. | |. .... . ..      |  . ....|.|.|.| |.|| |
pvlsapp...tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna......lfipnvsaedsGtYtCrasnseg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1237-1316 8.4e-09 29.4 In-house 32-116 (347) alignment 
Range on Protein: 1237-1316
Range on HMM: 32-116/347.0
SNLETNKPKNRYANVIAYDHSRVILSPMEGL-----PGSDYTNANYCDGYRKQNAYIATQGPLLETMADFWRMVWEQRTNTIVMM
.. | .  |||  .|   | .||.||| .       .   | || .      .. || || || .|. |||.||   .   .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
Ig_2 Immunoglobulin domain 170-247 1e-08 27.1 Pfam-A 6-80 (80) alignment 
Range on Protein: 170-247
Range on HMM: 6-80/80.0
PENQEVVPGGSVNLTCAAYGSPMPRVRWMKAGMDLDdmddlpIGRN--VLQLRDIYESANYTCVATS-LLGTIDTSARVTV
.....|  | .|.|||.| | | |.| | | |  |.       ..|   ...    .| .|||.|.   ...  .| .|||
apptvvtegenvtLtCqapgnptpkvqwykdgeels......qsqnalfipnvsaedsGtYtCrasnsegskqsnsvevtv
0038934 (Phosphotyrosine protein) phosphatases II 1670-1759 1.6e-08 29.9 In-house 85-170 (194) alignment 
Range on Protein: 1670-1759
Range on HMM: 85-170/194.0
W--PEQGVPKSGEGFIDFIGQVHKTKEQfGQEGPISVHCSAGVGRTGVFITLSVVLermrYEGIvDMFQTVKMLRTQRPAMVQTEDQYQFCY
.  |..|.. | |   .|.  |..  ..  ..| . ||| ||.||||...    .     . |. .. . ....|  || .... |...  .
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiy....rlgm.saeeAialfrekRpgaipnqdyleall
Ig_3 Immunoglobulin domain 167-234 1.2e-07 23.8 Pfam-A 5-75 (75) alignment 
Range on Protein: 167-234
Range on HMM: 5-75/75.0
TILPENQEVVPGGsVNLTCAAYGSP-MPRVRWM-KAGMDLDDMDDLPIGRNVLQLR--DIYESANYTCVATS
.. |.. ... |. |.||| | |.|  |...|. . .. |.  ... .. ..| ..  .   | .|||||..
svspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_PTPDC1_pd Subfamily PTPDC1 1367-1469 1.2e-07 26.3 In-house 77-170 (182) alignment 
Range on Protein: 1367-1469
Range on HMM: 77-170/182.0
SMEKREVKQFQFtAWPDHGVPEhATSVLAFISRVKSCNppDAGPIVVHCSAGVGRTGAYIVIDSMlerikHEKTVDIYGHVTCLRAQRNYMVQTEEQYIF
.. ....  ..| .|.|.||.   ...|  .  |...   . | . ||| || ||||  |    .     . | ..    .. .|..|   .|| ||  .
almeqgiyvynf.gwkDygvas.leriLdivkvvafal..qegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvel

IHE
..|
vke
fn3 Fibronectin type III domain 843-932 1.9e-07 24.3 Pfam-A 1-85 (85) alignment 
Range on Protein: 843-932
Range on HMM: 1-85/85.0
SAPLDLRCAAPHGTQLEVKWSHPSniQRSGPGYNYLVYSTNSADNTdvS-TWGRpVSAGEFtKLELRGLQEETTYYVAVKLDTPEGNSPLS
||| .|.. .   |.|...||.|.  ...||  .| |   .. ..     .. . |.. .   ..|.||.. |.| . |.  . .|..| |
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge..ewkeft.vprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1237-1335 3.4e-07 23.3 In-house 22-88 (169) alignment 
Range on Protein: 1237-1335
Range on HMM: 22-88/169.0
SNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNAnycdgyrkqnayiatqgplletmadfwRMVWEQRTNTIVMMTKLEERNrvkcdQYWPTRD
..| .|. ||| |  .|  | || |  .    |||| ||                           ||.||  .  ||..   ...|     ..|| ..
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpeke
0038934 (Phosphotyrosine protein) phosphatases II 1379-1427 3.4e-07 25.6 In-house 85-134 (194) alignment 
Range on Protein: 1379-1427
Range on HMM: 85-134/194.0
TAWPDHGVPEHATSVLAFISRVKSCNPPD-AGPIVVHCSAGVGRTGAYIV
  .||.|..     .| |.. |.  .  |  | ..||| ||.||||  ..
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1237-1335 4e-07 23.0 In-house 21-87 (169) alignment 
Range on Protein: 1237-1335
Range on HMM: 21-87/169.0
SNLETNKPKNRYANVIAYDHSRVILSPMEGLPGSDYTNAnycdgyrkqnayiatqgplletmadfwRMVWEQRTNTIVMMTKLEERNrvkcdQYWPTRD
..| .|. ||| |  .|  | || |  .    |||| ||                           ||.||  .  ||..   ...|     ..|| ..
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpeke
subfamily_eak_pd Subfamily eak 1403-1475 5.1e-07 23.4 In-house 232-305 (332) alignment 
Range on Protein: 1403-1475
Range on HMM: 232-305/332.0
CNPPDAGPIVvHCSAGVGRTGAYIVIDSMLERIKHEKT--VDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEAV
  ||   ||.  .. |  |.|...||| ... |   |.    .   .   . .|.. | .. |. ||.|.. . .
htppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1231-1282 6.5e-07 23.2 In-house 28-78 (244) alignment 
Range on Protein: 1231-1282
Range on HMM: 28-78/244.0
QFTWDHSNLETNKPKNRYANVIAYDHSRVILSPMEgLPGSDYTNANYCDGYR
.|    . | .|  |||| |.. .|..|||||  .   |||| |||| .| .
eflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq
fn3 Fibronectin type III domain 946-1038 1.2e-06 21.7 Pfam-A 2-84 (85) alignment 
Range on Protein: 946-1038
Range on HMM: 2-84/85.0
EPRSFDAHIASDNTINLVWSEPSDIPGRLKDYVIKYHTSDDFRreypdyydggGEIEILASEQRVSLSGQLFKPNMEYEFNITARTEAIRGPP
.|. . ..  ......| ||.|.|  | .. | ..| .... .           . |. ....  |.  .  ||..||||...|...|  ||.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_CDC14_pd Subfamily CDC14 1699-1760 1.2e-06 22.6 In-house 263-318 (328) alignment 
Range on Protein: 1699-1760
Range on HMM: 263-318/328.0
EGPISVHCSAGVGRTGVFITLSVVlERMRyegiVDMFQTVKMLRTQRPAMVQTEdQYQFCYH
|| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  | .|...
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigp.qqkflee
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1525-1624 1.3e-06 21.4 In-house 21-88 (169) alignment 
Range on Protein: 1525-1624
Range on HMM: 21-88/169.0
SANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINAshidgyrqrnayiatqgplaettedfwRMLWEQNSTIIVMLSKLremgrEKCHQYWPAER
 |.. .|. |||          || || .    |||||||                           ||.|| |...||.|        .   ..||   
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1525-1623 1.9e-06 20.8 In-house 20-86 (169) alignment 
Range on Protein: 1525-1623
Range on HMM: 20-86/169.0
SANIPANKFKNRLLNIQPYEGNRVCLQPIRGVEGSDYINAshidgyrqrnayiatqgplaettedfwRMLWEQNSTIIVMLSKLremgrEKCHQYWPAE
 |.. .|. |||          || || .    |||||||                           ||.|| |...||.|        .   ..||  
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek
subfamily_PRL_pd Subfamily PRL 1690-1737 1.9e-06 22.0 In-house 81-128 (151) alignment 
Range on Protein: 1690-1737
Range on HMM: 81-128/151.0
HKTKEQFGQEGPISVHCSAGVGRTGVFITLSVVLERMRYEGIVDMFQT
 |.| .   .  ..||| ||.||. |...|... . |.||  |.. ..
lkekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefire
PTPc_motif_SM00404 1655-1751 2.9e-06 22.2 In-house 42-127 (140) alignment 
Range on Protein: 1655-1751
Range on HMM: 42-127/140.0
RDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQEGPISVHCSAGVGRTGVFItlsvVLERMRYEGIvDMFQTVKMLRTQRPAMVQT
.  ....| | .  |  .. . |  .  .||| ..        ..| . ||| ||| |.. .|    . . |||... .. . ..... .||.. ..
kensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrql.slaeayefvkerRpiispn
PTEN_1 1326-1423 4e-06 21.8 In-house 42-145 (196) alignment 
Range on Protein: 1326-1423
Range on HMM: 42-145/196.0
KcdQYWPTRDQEKYGFIQVTLLDTTELATYTVRSFALVKN---RSMEKREVKQFQFT----AWPDHGVPEHAtSVLAFISRVKSCNP--PDAGPIVVHCS
.  ...... .. . ...  | .  |   ..| .... ..   || ...| .. ...     ..|||.|  . ...... .....    |. . ..||| 
q..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCk

AGVGRTG
||.||.|
aGlgRsG
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1327-1483 4.4e-06 20.4 In-house 150-309 (332) alignment 
Range on Protein: 1327-1483
Range on HMM: 150-309/332.0
CDQYWPTRDQeKYGFIQVTLLDTTELATYTVRSFALVKNRSMEKREVKQFQFTAWPDH-GVPEHATSVLAFIS--RVKSCN--PPDAGPIVVHCSAGVGR
| ..|| .   |  |  ...  . . .   ...| |      . ..   ..|  | |   .||.   . | |    ..| .      |||.. |..|| .
crkfwpekrs.kkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgvek

TGAYIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALYEaVASGTTEVH
   .  || .. ||  |. | .   ..... ||   ..|   |    | | . .|  |  ||
caisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmk.favttgvvh
ig Immunoglobulin domain 88-140 9.6e-06 16.9 Pfam-A 4-63 (64) alignment 
Range on Protein: 88-140
Range on HMM: 4-63/64.0
ATIYCGA-TGNPEPEILWFKEFVPIEANDRISMTDSG------LQFSRAQLSDQGRYECA
.|. | . .|.|.... |.||  . | ....  .. .      |...... .| | |.| 
vtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv