Gene PTPRG in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP075_AA protein Get Run
SpurP075_AA_634-915 phosphatase_domain Get Run
SpurP075_AA_926-1215 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRG_pd Subfamily PTPRG 632-929 4.8e-146 482.2 In-house 1-302 (563) alignment
Range on Protein: 632-929
Range on HMM: 1-302/563.0
IHISKFESHVIACHANSDGGFAAEYE--EIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNS-DYINANYIDGFNRQKAYIATQGAL
.....|..||...||..| ||..|.|  . ........|..|.. ||| ||||.|||.||.|||.|.||||. .. ||||||||||....||.|||||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

KTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKV--PERRVYHFHYTDWPDHGVP
|.|||||||..|||.. .|||||.|.||||||||.|||.  ..|.|..|.|||. .|..|.|| ||. .|....|..|    |..|...|||.|||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

PYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTEL
 ..||||.|...|||||...||||.|||||||||||||||.||.|||.|.|..||||||||.||.|||.||||||||.|.||.|||......| ......
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

RQY
.. 
eel

subfamily_PTPRD_pd Subfamily PTPRD 630-937 5.7e-135 446.1 In-house 3-304 (564) alignment
Range on Protein: 630-937
Range on HMM: 3-304/564.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
..|.......||   .||||  |  ||..|..  ..|. . ..  .|| |||| ||| ||.||| |....| ..||||||..|||....|||||||| |.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGtPERYNELEVTLELKEKFASYTLRTFLLkHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYT
.|..||||.||||.| .|||.|||||.|. ||..|||.|| .|.|.||.|||| .|..| |..||| | ...|.. .   | | .||.|.||||||| ..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkksses...reVrqFhFtsWPdhgvpesa

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQY
 ..|..|....|.|..|||||.||||||||||||.|||| ||.....|..|......|..|.|||..|||||||.|||...|| | .||| |.| .|.| 
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh

VDRMTLPD
.....  .
lqkLaeve

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 632-948 6.7e-115 378.5 In-house 2-315 (318) alignment
Range on Protein: 632-948
Range on HMM: 2-315/318.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
|.....||||   ... .  . .|||...... .. .. | .  || ||||.||..||..|| ||.| | ..|||||||||||..|.|||||.|. |  |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLP
..||||.||||.| ||||.|..||||..|..|||| ||. . |..| |.|. . ....|.||.| ........    .| |  .|||.|||.|||  .  
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeee....srqvrqyhytsWpdegvpesgas

VLSFIQRSSAAN-PTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV
.|......|.|. ...||||.|||||||||||..|..|..|....||. |.||.. |..|.||| .||||.||.||.||||| | .|.| |....||. .
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsri

DRMTLPD-EVGRVVLDEQF
 ... .| |.|.  .| .|
relreqdpesgttemdaef

subfamily_PTPRB_pd Subfamily PTPRB 631-917 6.3e-105 345.4 In-house 6-288 (293) alignment
Range on Protein: 631-917
Range on HMM: 6-288/293.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKT
 |...|||.||   .|.|| .|. ||||...| ..   ....  .|. |||||||..|| ||| |..| . ..|||||||||.|.| .. .||||| | .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHrhkkhgKVPERRVYHFHYTDWPDHGVPPYTL
|.|||||.|||.|| .|||.|.| |.|. ||..||||. .|  | ...|||  .|.   ...|......      .  ||.| ..|.| |||||||  | 
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek......ekeerkvrqyhftsWpdhgvPektk

PVLSFIQRSS--AANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
..|.|...    . . ....||.||||||||||||.| .|..|.... |. |..||.. ..|..||.|||||.||.|||...|. || .
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

0051299 (Phosphotyrosine protein) phosphatases II 630-914 1.7e-104 344.6 In-house 3-286 (288) alignment
Range on Protein: 630-914
Range on HMM: 3-286/288.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
 .|........| . .||.  |...|.||.... .... .... .||. ||||..|. ||.||| |..|.|...||||||.||||.|.....||||| |.
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYT
.|..||||.||||.. ||||.|||.|.||.||..|||  |... |... |||   |....||.||. ... .  .|.  .|.|.|||||.|||||||...
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
 ..|.|...   |.. . ||..||||||||||||.|..|..| |...|..|.|....||.|.||...|||.|||.|....|||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 631-931 1.8e-103 340.9 In-house 4-300 (319) alignment
Range on Protein: 631-931
Range on HMM: 4-300/319.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHvPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKT
 |.. ...... | ..... ... |...... ....  . .|  ||| ||||.||..|| .|| |..|.|...||||||..|||.......||||. |..
eievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPaKGTPERYNELEVTLELKEKFASYTLRTFLLkhrHKKHGKVPERRVYHFHYTDWPDHGVPPYTL
|..||||.|||..| ..||.||| |... |. .||| . ..|.| .| |||| .|. . |  | . |   .|| ..|  |.| ||.||.||||.|| ...
tiedfWrmvWeeessivvmltklveklkvklkkywp.eenfeeyGrlivtleeeeeledyiirklkl...nkkssevetRevkhfqyteWpdhdvPekat

PVLSFIQRSSAAN-PTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQY
 .| ...|   .   |..|||.||||||||||||.||.| || ... |. ..|| . .|.||||| .||..||| ||...|||.. ||.| ..  .||. 
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdr

VD
. 
lk

subfamily_PTPRG_pd Subfamily PTPRG 942-1219 2.5e-103 341.2 In-house 19-289 (563) alignment
Range on Protein: 942-1219
Range on HMM: 19-289/563.0
VVLDEQFN-LIMKMKPR--DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG---YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTT
. ..|.|. |.......  |.|.|.....|.|||........|||| .|..||...   ||||....||......|.||.|...|..|||.|.||.|...
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVTLTD---DQKEDEPIYWPTnvDEPLTLGALTITLWKRNTLISPSSQgkflgqssqgthtPLVIQN---KEFDD-DDQLNVRQYHCSYWPDCCSPLHTA
||..|.   ........|||.  ||..|.|||..||.....|......              |||.|   |.... |....|||||...|||...| |..
ivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvr.............tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

FDLIYAVQKrneflERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHSA
..||.....     ...||...|||.||...|....||...|.||.... .|.||......| ..|.|..|....|.|..|..||... ..
pvLifvkks.....saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

0050432 (Phosphotyrosine protein) phosphatases II 620-917 1.7e-99 328.3 In-house 12-302 (308) alignment
Range on Protein: 620-917
Range on HMM: 12-302/308.0
TFCRPDDLEEPAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLqplpGiPNSDYINANYIDGF--NR
...|....    ...|  . . .  .|.. |.. .|.||...|..... .... .||| ||||..|. ||.||| |    . ..||||||.|.||.  ..
llfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgysskl

QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK--GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkvPERRVYHF
....||||| |..|..||||.||||.. ||||.|||.|.|| ||..||| .  |....|. . |||   |....||.||. |..  ..    ..|.|.||
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg....esrtvthf

HYTDWPDHGVPPYTLPVLSFIQRSSAANptDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
|||.||||||||.. ..|.|...    .  . |||.||||||||||||.|..|..| |...| .|.||. .|..|.||.. |||.|||.|....|||.|.
hytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

AG
  
lk

0040438 (Phosphotyrosine protein) phosphatases II 636-943 5.1e-98 323.5 In-house 4-305 (317) alignment
Range on Protein: 636-943
Range on HMM: 4-305/317.0
KFESHVIACHANSDGGFAAEYEEIQHVPTSfPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDF
... ..  ..... ...  |.|...... . . .... .||| ||||..|. ||.||| |.||.|...||||||.|.||.|.....||||| |. |..||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkhGKVPERRVYHFHYTDWPDHGVPPYTLPVLSF
||.||||.. ||||.|.|||.||.||..|||  |..  |... |||   |. |..||||. ...     |. ..|.|.|||||.||||||||.. ..|.|
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl....gdsesrtvthfhytgWpdhgvppspdllldf

IQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDRMTL
...  .|.. . ||..||||||||||||.|....|| |.. |..|.|.  .|..| ||.. |||.|||.|..|.|||.|. ..| .  .||  ...... 
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli

PDEVGRVV
|. ...| 
plalddvk

0046845 (Phosphotyrosine protein) phosphatases II 651-919 1e-95 315.7 In-house 1-279 (284) alignment
Range on Protein: 651-919
Range on HMM: 1-279/284.0
GFAAEYEEIQHVPTSF--PATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPG-IPNSDYINANYIDGF-----NRQKAYIATQGALKTTFDDFWRLVWEQ
|. .|.||.... ...  . ...  .||. ||||..|. ||.||| |..|.| ...||||||.|.||.     ...|..||||| |..|..||||.||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHK-KhgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA
.. ||||.|.|.|.|| ||..||| .|.. .|... |||  .|.. .||.||. |.. .  .    ..|.|.|||||.||||||||.. ..|.|..    
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytg....esrtvthfhytswpdhgvppspedlleflrlvre

ANP--TDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEE---KVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNT
...   . |||.||||||||||||.|..|..|.|...|.   .|.|.. .||.|.||.. |||.|||.|....|||.|. ..|
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

subfamily_PTPRA_pd Subfamily PTPRA 631-933 1.8e-95 314.6 In-house 13-314 (330) alignment
Range on Protein: 631-933
Range on HMM: 13-314/330.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKT
 . . |.|  .    |.    |  |.. .   |       .|  ||| |||. ||. || ||| |... |...|||||| .|||..... .||.|| .. 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTL
| .||||..|||||  |||.|.|.|| . || .||| .|.   | .. |..| ..   .||.| ||...  ..  . ..| |  ||.| ||| |||  . 
tvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi

PVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV
 .|.....  . |.  ||||.||||||||||||.||.|..|....||.||.||.|.||.|.||  .|||.|||.||. ||||.   |.| .. . | ...
GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhl

DRM
...
qkl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 632-914 2.3e-94 310.7 In-house 4-279 (288) alignment
Range on Protein: 632-914
Range on HMM: 4-279/288.0
IHISKFeSHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
||||.  ..|.  .|..  ||  ||. .  .  .   | ..  .|. |||| ||..||  || |. |.  ...|||||.|||| ...|.|||||| |  |
ihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKhrhkkhGKVPERRVYHFHYTDWPDHGVPPYTLP
 .|||.||.|.|.  |||.|.| |.|..||..|||....|..| ...|||  ...  ...||..||.       |  |... ...|. |||||||  . |
vndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskap

VLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
.| ...    ||. |.||||||||||||||||.|..|........|....|.|.....| ||. ||||..||.||..|||.  
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

0036941 (Phosphotyrosine protein) phosphatases II 645-922 4.1e-94 310.5 In-house 8-285 (297) alignment
Range on Protein: 645-922
Range on HMM: 8-285/297.0
HANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLqplPGiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKS
....  ..  |.||....  ... . .. .||. ||||..|. ||..|| |   .. ..||||||.|.||.......||||| |..|..||||.||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

VVIVMITKLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEK--FASYTLRTFLLKHRHKKhgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA
 ||||.|.|.|.|| ||..||| . | .  |... |||   |.  ...|||||. ...  ..    ..|.|.|||||.|||||||... ..|.||..   
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng....esrtvthfhytgwpdhgvpespaslldfielvrk

ANPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQ---AEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVK
...   . ||..|||||||||.||.|..|.|| |..    |..|... ..| .|.||.  |||.|||.|....|||.|. ..|.. 
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep

0047943 (Phosphotyrosine protein) phosphatases II 645-914 5.9e-93 306.5 In-house 7-272 (273) alignment
Range on Protein: 645-914
Range on HMM: 7-272/273.0
HANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLqplpGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKS
.... .....|.|... ...... .... .||| ||||..|. ||.||| |    | ..||||||.|.||.|.....||||| |. |..||||.||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

VVIVMITKLEERGRRKCDRYWPAKGT--PERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAA
 ||||.|.|.|.||.||..||| .|   ...|... |||   |....||.||. |.. . ..    .| |.|||||.||||||||.. ..|.||.    |
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge....srtvthfhytgwpdhgvppslesllefielvrka

NPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
. .  . ||..||||||||||||.|..|..| |...| .|.|.  .|..|.|| . |||.|||.|....|||.|
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 632-933 1.3e-92 305.3 In-house 4-302 (305) alignment
Range on Protein: 632-933
Range on HMM: 4-302/305.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFpaTFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
| ........   ...|| |. |.|..... ..|.     .. .|| |||...|. .| .|. |.. .  ..||||||.|.||..|.|.||..|| ||.|
ialddlaayikearvysdkgleaqykslyeeeesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTP-ERYNELEVTLELKEKFASYTLRTFLLKHRHKkhgKVPERRVYHFHYTDWPDHGVPPYTL
 .|||||..| | ..|||.||| | |. || .||| . |  ....|..|.|. ..... |. | . .  ...   .  .| | ... ||||||||| .. 
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvpqfat

PVLSFIQRSSAANPTDAG-PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQY
 .||.|.|   .   | | |..|||||||||||..|..| .| ....|| |.||. ||..|..| ..||| .||||.||.| | . .|.| .    ||  
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

VDRM
|...
vnkl

0043336 (Phosphotyrosine protein) phosphatases II 632-914 1.6e-92 305.2 In-house 2-277 (278) alignment
Range on Protein: 632-914
Range on HMM: 2-277/278.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTsFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
|...... ... ...|.  .. .|.||...... .. ...  .||| ||||..|. ||.||| |..|.| ..||||||.|.||.|.....||||| |. |
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPakGTPERYNELEVTLELKEKFASYTLRTFLLKHrhkkHGKVPERRVYHFHYTDWPDHGVPPYTLP
..||||.|||... .|||.|.|.|.|| ||..|||  |....|... |||   |... ||.||. ...    .|. ..| |.|.||..|||||||. . .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpeslsl

VLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
.|.|...   |.... ||..||||||||||||.|.....| |.. | .|...  .|..|.||   |||..||.|....|||.|
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 632-914 2.1e-92 305.4 In-house 9-304 (307) alignment
Range on Protein: 632-914
Range on HMM: 9-304/307.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPT--SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGI-PNSDYINANYI--------DGFNRQKA
| . |....|   ....  |...|.|....| .  ... .... .||| ||||..|. ||..|| |..|.|  ..||||||.|.        ||......
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

YIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkHGKVPERRVYHFHYTDW
.||||| |. |..||||..|||.. ||||.|.|.|.||.||..||| .|..  |... |||  .|. ..||.||. ...    .|. ..|.|.|||||.|
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgw

PDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEK---VNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|||||||.. ..|.||..  .|. .  . ||..||||||||||||.|....||.|...|..   |...  .|..| ||   ||..|||.|....|||.|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0039614 (Phosphotyrosine protein) phosphatases II 622-918 1.2e-91 302.6 In-house 4-293 (297) alignment
Range on Protein: 622-918
Range on HMM: 4-293/297.0
CRPDDLEEPAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSfpATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGI-PNSDYINANYIDGFNR-QK
.|.  || . |..| .. ..   .||| ... .|.||.. .. .   ...  .||| ||||..|. ||.||| |.|..|  ..||||||.|.||... ..
lrdallesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

AYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRrKCDRYWPAKGTpeRYNELEVTLELKEKFASYTLRTFLLKHrhkkHGKVpeRRVYHFHYTD
..||||| |. |..||||.||||.. ||||.|||.|.|| ||..||| .|.  .|... |||   |. . ||.||. ...    .|..  | |.||.||.
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn....nges..rtvthfqytg

WPDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
||||||||..  .|.|..    |. .  . ||..||||||||||||.|....|| |.. | .|.|.  .|..| ||.. |||..||.|..|.|||.|. .
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

N
.
l

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 644-921 6.1e-91 299.8 In-house 21-297 (298) alignment
Range on Protein: 644-921
Range on HMM: 21-297/298.0
CHANSDGGFAAEYEEIQHVPT---SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVW
 ....  |.|.|......|     ..  . ..  ||| ||||..|...||||| |.   .  .|||||| .........|.||||. |..|. ||||.|.
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSS
|... .|||.|.||| .. |. .||| .|. |.|.|..|.|  ||.|| .. |.. .......     ||.| ..|.| |||.||| ..  || ....  
eedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkee....kerevrqlhftsWpdkgvpenatsvldllrkvr

AaNPTDAG--PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVV
| ....||  |.||.|||||||.||.|.||..| ....|..| ||  .|..|..|  .||||||||||... || | ..|. .
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

DSPc_SM00195 652-914 8.5e-90 296.0 In-house 2-262 (263) alignment
Range on Protein: 652-914
Range on HMM: 2-262/263.0
FAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
. .|.|...   .. . | .   .|| ||||.||. ||..|| |.. .. ..|||||||||.| |..|.|||||| |..|..||||.|||.|. .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEKFA-SYTLRTFLLKHRHKkhgkVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGP
. ||.|..||||||| . |..|......|.|  .||   ...|||. |..  |      .|.|....|..|||||||  | .||....     . |  ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|.||||||||||||...||..|.....|.||..|  .|..|.||  .|||.||| ||....||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 652-914 8.5e-90 296.0 In-house 2-262 (263) alignment
Range on Protein: 652-914
Range on HMM: 2-262/263.0
FAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
. .|.|...   .. . | .   .|| ||||.||. ||..|| |.. .. ..|||||||||.| |..|.|||||| |..|..||||.|||.|. .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEKFA-SYTLRTFLLKHRHKkhgkVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGP
. ||.|..||||||| . |..|......|.|  .||   ...|||. |..  |      .|.|....|..|||||||  | .||....     . |  ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|.||||||||||||...||..|.....|.||..|  .|..|.||  .|||.||| ||....||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Ptp69D_pd Subfamily Ptp69D 630-932 5.1e-88 290.1 In-house 2-304 (307) alignment
Range on Protein: 630-932
Range on HMM: 2-304/307.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
.||.| . |. . . . ..| |.| |||....  ..  ...|   ||.||||| .|...|. || |....|  .||||||..| |.. .| .|| |. . 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKgTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPE-RRVYHFHYTDWPDHGVPPY
.| .||||...||.. .|||...|.|  |.||..|||   .  .|... |.|  .||   |. |.. . . ... |.|.. |.|  .||| |.|  ||  
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

TLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQ
.  .| .|..    . .. .||.|||||||||.|... .| .|.|..||.||..| . | .| ||| |||  |||||..  ||..   |.| ..  .| .
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

YVDR
 ..|
aier

subfamily_PTPRK_pd Subfamily PTPRK 630-937 2e-87 288.0 In-house 2-301 (314) alignment
Range on Protein: 630-937
Range on HMM: 2-301/314.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVptsfpATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
|||..     ..   ...   ||  ||| .           . . ||. |||...|..|| ||| |... | |.||||||..||...| .|.|.||| |.
pairvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPerYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVPERRVYHFHYTDWPDHGVPPYT
 |  ||||||.....  |||.|.| | || || .||| ...   |....|.|   |  | .  |.| ... ..  |.   | | .|... ||||.|| . 
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklar..gqeeirevrqfqflgWpdhdvPvsa

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQ-
  .|....|  . .. .||.|.|||||| |||||.|.||..|  .. |. |.||   | .|...  .|.|||||.||.||.||   .|.| .  .|..  
tgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkal

YVDRMTLPD
|.. . |  
ylesirldp

subfamily_PTPN6_pd Subfamily PTPN6 648-920 1.5e-86 285.2 In-house 24-303 (306) alignment
Range on Protein: 648-920
Range on HMM: 24-303/306.0
SDGGFAAEYEEIQHV--PTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQpLPGIPNSDYINANYIDG--FNRQKAYIATQGALKTTFDDFWRLVWEQK
.  ||  |.||.|.    . .  . .. .||| |||| ||. .| .||.|.  |..|.|||||||||..   . .|.||||||.|.||  ||||.||...
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

SVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQR----S
| ||||.||  |||. || ||||.. . |.| ...||   ... |.|.||.......   . |  ||.|...|...|||||||  .  ||.|..     .
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk...kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQA---EEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTV
.  . ..||||.||||||.|||||.||||..||...    . ....  . | .|.||. |||||.|| |.. .. ..... ...
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl

Y_phosphatase Protein-tyrosine phosphatase 676-912 5.3e-85 279.9 Pfam-A 1-235 (235) alignment
Range on Protein: 676-912
Range on HMM: 1-235/235.0
NKLKNRYTNIVSYDSSRVSLqplPGIPN-SDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWP-AKGTPER
|| ||||..|. ||..|| |    | .. ||||||||..|....|..||||| || |..||||.||..|. ||||.|.|||.||.||..||| .......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YNELEVTLELKE--KFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTML
|....|.|. ||  . ..||||.. ||.. ...    .|.|...|||.|||||||  . ..|..|..    . .. ||..||||||||||||....|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
.|..|||.|.|. ..|..|.||. .||..|||.|.....||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 676-912 5.3e-85 279.9 In-house 1-235 (235) alignment
Range on Protein: 676-912
Range on HMM: 1-235/235.0
NKLKNRYTNIVSYDSSRVSLqplPGIPN-SDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWP-AKGTPER
|| ||||..|. ||..|| |    | .. ||||||||..|....|..||||| || |..||||.||..|. ||||.|.|||.||.||..||| .......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YNELEVTLELKE--KFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTML
|....|.|. ||  . ..||||.. ||.. ...    .|.|...|||.|||||||  . ..|..|..    . .. ||..||||||||||||....|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
.|..|||.|.|. ..|..|.||. .||..|||.|.....||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0040439 (Phosphotyrosine protein) phosphatases II 669-914 4.6e-84 277.2 In-house 4-246 (249) alignment
Range on Protein: 669-914
Range on HMM: 4-246/249.0
TFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAk
.... .||| ||||..|. ||.||| |..||| . ||||||.||||.......||||| |. |..||||..||... ||||.|.|.|.|| ||..|||  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkhGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIV
|..  |... |||   |....||.||. |..     .. ..|.|.|..|||||||||||.. ..|.||..   |. .  . ||..||||||||||||.|.
ggsleygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
...|| |.. | .|...  .| .|.||.. ||..|||.|....|||.|
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 673-916 2.2e-83 274.3 In-house 6-244 (250) alignment
Range on Protein: 673-916
Range on HMM: 6-244/250.0
DVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRkCDRYWPAKGtPE
. .|| ||||..|...||||| |..  |  .|||||| ...|.. .||.||||| |..|. ||||.|.|.|| .|||.|.|.| ..  . .|||... .|
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.ae

RYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT-DAGPIIVHCSAGVGRTGTYIVIDTML
.| .. |.|  ||.|| || |.. | ...|..    || | ..|.. ||| ||| ..  || ....  | ..  ...|.||.|||||||.|..|.||..|
kyGdvtvsllskeefadytkrklklskakkad....erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRA
.... |..|.|| ..|..|..|   |...|||||.. ..|. | .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 639-915 9.4e-83 272.5 In-house 4-277 (281) alignment
Range on Protein: 639-915
Range on HMM: 4-277/281.0
SHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRL
 |. . ..|.. ||. |||..... .. .|| |   ||.|||||.|||.|| .|| ..|     |.||||||...|.. .|.|||||| . .....||..
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLkHRHkkhgKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQR
|||||  .|||.|.  | |. || |||| . .  .| .. |. . .|. |.|  |.| | .|.    . ..|.| ...|| |||||||  |  .|.| . 
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.ere....sgetreveqlaytaWPdhGvPattkellefrke

S-SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE-EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
  .. ..    |...||||||||||||| .|...|...|| |...|   .. .| .||..|||  || |.. ..|. | 
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 635-949 1.9e-82 271.7 In-house 9-315 (315) alignment
Range on Protein: 635-949
Range on HMM: 9-315/315.0
SKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDD
 .. ..|   .|..  ||  .|| |      .|   . ..||| |||| ||..|| ||| |  |   |.|||.|||.|||.|... |||.|| . .. .|
dqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkd

FWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKgtPERYNELEVTLELKEKFASYTLRTFllkhrhK--KHGKVpeRRVYHFHYTDWPDHGVPPYTLPV
|||||.|..   |||.|.| |. .||...||| |     | .. ||.  .|..  || ||.            ..  | |. .||| ||| ||| ||.|.
fwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl......svvfgdni..revvqlhytswpdmgvpkytipl

LSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVK-STELRQYVD
. .|..    . ...|.|.||||||||||||.| .|..|.|..||. ..|. |....| .|  .||. ||| ||.|.||| . .|.| .     | .|  
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryds

RMTLPDEVGRVVLDEQFN
 ..   . |  .|.|||.
llapspdtgstllqeqfe

subfamily_PTPN9_pd Subfamily PTPN9 634-914 1.9e-81 268.4 In-house 3-290 (297) alignment
Range on Protein: 634-914
Range on HMM: 3-290/297.0
ISKFESHViacHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFD
|......|   ...   |   ||.||.. |..  .. |    |  |||||... ||..|| |. ... ..|||||||..||....||.|||||.|| |..
ieelvayv...kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRLVWEQKSVVIVMITKLEERGRRKCDRYWP-AKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPV
||||.||||. .||||.|...||||.|| .|||  ... ... .|.|.    |.   |. |.. .|. ....    .|.| || .. |||.|||  .  .
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee....srkvthfqflsWPdyGvPssaasl

LSFIQRSS-------------AANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
| ...                 . ...  ||.||||||.|||||.| .|  |.... ...|.|.  .|..|||| . .||.|||.| .  .||. 
ldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

0042113 (Phosphotyrosine protein) phosphatases II 671-914 7e-81 266.5 In-house 4-243 (245) alignment
Range on Protein: 671-914
Range on HMM: 4-243/245.0
SSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGT
.. .||| ||||..|. ||..|| |.| .| . ||||||.|.||... . .||||| |. |..||||..||... .|||.|..||.|| ||..|||  |.
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PERYNELEVTLELKEKFASYTLRTFLLKHrhkkHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANP-TDAGPIIVHCSAGVGRTGTYIVIDT
. .|... |||   |....||.||. ...    .|. ..| |.|.||..|||||||...  .|.|...   |   .. ||..||||||||||||.|....
sltygdftvtllseehlddytvrtlevtn....lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

MLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|| |...| .|...  .|..| ||   |||..||.|....|||.|
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0045098 (Phosphotyrosine protein) phosphatases II 650-917 9.2e-81 266.5 In-house 7-275 (278) alignment
Range on Protein: 650-917
Range on HMM: 7-275/278.0
GGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSlqplpgipnsDYINANYIDGFnrQKAYIATQGALKTTFDDFWRLVWEQKSVVIVM
. .  |.|.. . .     |..  ..|. ||||..|. ||.|||           |||||.||||.  .|..||||| |..|..||||..||... ||||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

ITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYT--LPVLSFIQRSSAANPT--
.|.|.|.|| ||..|||  | ...|....|||.  | .  |||||.|. . . ..   ..| |.|.||. |||||||...   ..|.....  .|. .  
ltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------DAGPIIVHCSAGVGRTGTYIVIDTMLKQMqaEEKVNVFGFLKRIRTQRNY-LVQTEEQYVFIHDVLLEWLRAG
           . ||..||||||||||||......||...  |..|...  .| .|.||..  ||..|||.|....|||.|. |
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 652-932 2.8e-77 255.1 In-house 36-309 (319) alignment
Range on Protein: 652-932
Range on HMM: 36-309/319.0
FAAEYEEIQHVPTSF-PATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
. .|.  . .....    ||.   .|| |||..||...| ..| |..| |.  |||||| ...|. |.. |||.|| |. | .||||..||...  ||..
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TkleergRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSS--AANPTDAG
|      . || .||| |.  ..... .| ... |. | |..| . | .  |....   |..  ||.  |||.||| |. ... .... .       .  
t......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdi...rkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDR
.|.|||||||||||.|||.|..|..|. |..|.|. |.. .| ||| |||   || ||.  |||    |.. |   ..  |...
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpaylee

subfamily_PTPN12_pd Subfamily PTPN12 663-918 5.6e-77 253.5 In-house 27-281 (290) alignment
Range on Protein: 663-918
Range on HMM: 27-281/290.0
PTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCD
 . .... ..  ||. |||| .|. || ||| |.   . ..|||||||.| | . ...|||.|| | .| |||||..||..  ..||. .. | |. ||.
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

RYWPAKGTP-ERYNELEVTLELKEKFA-SYTLRTFLLKHRhkkhgkVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGR
|||| .|    ...|.||||| ....   ...||. ....        .|.|| ||||.|||||||  . ..|..|.     . ... |..|||||||||
rYWpeegeeelefgefevtleeekavdddflirtLkveaq......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

TGTYIVIDTMLKQM---QAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGN
||| |.|| . ...   . .|...||  . ..|.||. ||||.|||....  ..| ...  
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 653-984 1.5e-76 252.6 In-house 21-351 (515) alignment
Range on Protein: 653-984
Range on HMM: 21-351/515.0
AAEYEEIQhVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITK
. |. ..   |  .| | . .  |  |||| ||. |||.|| |. .   |.|||.|| || .|. .|||||.|| .|.. |||||||....   |.|.||
seefhdlp.gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

LEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPII
|.|  . || .|||   |   .. ...| |   |  .  . |.. . .  .       | |  ||.|.|||.|||. |  .| .|.   | .   . |.|
lkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd......srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

VHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV-DRMTLPDEVGRVVLDEQFNL
.|||||||||| .| || .. ...  . |.|| |.. || .| |||||.||| ||....|| |   ||..    . ... |  .  |  ||  . ..|. 
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqt

IMKMKPRD----YEFSKARQSKHKNRDMDLIPVERSRV
.  . |         ...|... |||  . .|..|.||
lkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 668-932 4.8e-76 250.9 In-house 17-273 (284) alignment
Range on Protein: 668-932
Range on HMM: 17-273/284.0
ATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITkleergRRKCDRYWPA
 ||.   .|| |||...|...| ..| |..| |.  |||||| .| |. |.. |||||| |. | .||||..||...  ||..|      . || .||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

KGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSS--AANPTDAGPIIVHCSAGVGRTGTYI
|.  ..... .| ... |. . |..| . | .  |....   |..  ||.  |||.||| |. ... .... .       .  .|.|||||||||||.||
kiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdi...rkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDR
|.|..|..|. |..|.|. |.. .| ||| |||   || ||.  |||    |.. |   ..  |...
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpaylee

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 632-917 7.6e-74 243.2 In-house 2-286 (290) alignment
Range on Protein: 632-917
Range on HMM: 2-286/290.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPN--SDYINANYIDGFNRQKAYIATQGALK
| ..||  .|.  ||. . || .... ..    .. .|     .|||.||..||| ||  |. |.|..| ..   .|||| ||.|.. .|.|||||| ..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPErYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkVPERRVYHFHYTDWPDHG-VPPY
 |  |||.|.|..|. .|||.|.  | |. ||  |||...| . |.| ...|   |.. .|. |.. .|.....    ... | ... | |...| |. .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsa...gakqsvtqyqitnwdstgkvtnp

TLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
.  .|.. ..      .  ..|.||||..|||........| ..... |  ..||  ||. |.|.  .|||..|| .|....|. |   
qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 651-949 3.3e-73 241.3 In-house 20-313 (315) alignment
Range on Protein: 651-949
Range on HMM: 20-313/315.0
GFAAEYEEIQHvPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
 |. |. ..   |  .. . . . .|  |||| ||. .||.|| |. .  .|.|||||| || ... .|||||.|| ||.. |||||.|...|   |||.
lfseefhdlpd.PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TKLEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGP
||..|  . || .|||  |.   .. ...|.|   |  .  . | . ... ..       |.|  |..|.|||.||.  |  .| .|.   | | ..  .
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee......srtvtqfqftewPdkGvdkqtssllklikevkadngkkefs

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV-DRMTLPDEVGRVVLDEQF
..|||||||||||  | || ...|.. .. |.|| |.| .|..| |||||||.| ||.|..|| |   ||...   . ... |  |  |  ||  . ..|
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkef

N
.
e

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 658-915 7.2e-73 240.0 In-house 10-269 (274) alignment
Range on Protein: 658-915
Range on HMM: 10-269/274.0
EIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIP-NSDYINANYIDGFNR-QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEE
|  ..|. |.    .   .. ||||..|.  . |||.|..  .   .|.||||||| |... .|||.|||| | .| .||||....... ||||.|||.|
eflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklke

RGRRKCDRYWPAKGTP---ERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGkvperrVYHFHYTDWPDHGVPPYTLPVLSFIQRS---SAANPTDAGP
. ..|| .|.| .      |||...|.. | . .   |..|...||. ....       |.|. ||||||| .|  . ..|....       .. . ..|
aneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers......vkhywytdWPdhksPddantlldlvleveesreeenaklap

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
..||||||.|||| .| |.  ..|...|..|.|..    .| .|  .|||.||| .|| .| ..|.
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0037934 (Phosphotyrosine protein) phosphatases II 671-913 1.4e-72 239.4 In-house 5-241 (243) alignment
Range on Protein: 671-913
Range on HMM: 5-241/243.0
SSDVENKLKNRYTNIVSYDSSRVSLqplpgiPNSDYINANYIDGFNRqkaYIATQGALKTTFDD----FWRLVWEQKSVVIVMITKLEERGRRKCDRYWP
.. .||. ||||..|. || ||| |      ..|||||||.|....|   .||||| |. |..|    |||..||... ||||.|.|.|.|| ||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

akGTPeRYNELEVTLELKEKFASYTLRTFLLKHrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAA--------NPTDAGPIIVHCSAGV
  |.  .|....|||   | ...||.||.||..   .  . ..| |.|.||. |||||||. . ..|.|..   .         .  . ||..|||||||
..gev.tygdftvtllseehlddytvrtlllen...ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTYIVIDTMLKQMqaeeKVNVFGFLKRIRTQRNY-LVQTEEQYVFIHDVLLEW
|||||.|....||...    .|...  .|..|.||..  |||..||.|....|||.
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 675-912 1.7e-72 238.5 In-house 2-237 (237) alignment
Range on Protein: 675-912
Range on HMM: 2-237/237.0
ENKLKNRYTNIVSYDSSRVSLQPLPGipNSDYINANYIDGFNR-QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPER
|||.|||| |||.|| ||| |.   .  .||||||.|..||.   | |||.|| |... ||||..||..|  ||||.| | |. . || .|||    |. 
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIVIDTML
|  | |.|  ||.|. ||.|..|| .|....     | .. ...| |||.||| .|  .| | ..    .|   ..|| |.|||||||||| ..|||.||
ygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
.| . .. |... ... |  .| |..||..||||||...||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 676-912 1.1e-71 235.8 In-house 7-238 (239) alignment
Range on Protein: 676-912
Range on HMM: 7-238/239.0
NKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN-RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGtpERY
|| ||||.|||.|| ||| |. |   | ||||||.|.  ..   ||||||||.....  ||||..|... .||||.| | |  ..|| .|||      .|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sky

NELEVTLELKEKFASYTLRTFLLKhrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQM
 .| |||   | || | .|||..     . |.  || ||..|.| |||.||| |.  || . .. .  .   | | ..||||||||||...|||.||.| 
cnlrvtlrktevfadyiirtfvms....qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

QAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
. .. |..| ..| || .| ..||| |||||||  .||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 676-912 1.3e-71 235.5 In-house 8-239 (239) alignment
Range on Protein: 676-912
Range on HMM: 8-239/239.0
NKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN-RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGtpERY
|| ||||.|||.|| ||| |. |   | ||||||.|.  ..   ||||||||.....  ||||..|... .||||.| | |  ..|| .|||      .|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sky

NELEVTLELKEKFASYTLRTFLLKhrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQM
 .| |||   | || | .|||..     . |.  || ||..|.| |||.||| |.  || . .. .  .   | | ..||||||||||...|||.||.| 
cnlrvtlrktevfadyiirtfvms....qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

QAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
. .. |..| ..| || .| ..||| |||||||  .||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPN3_pd Subfamily PTPN3 650-911 1.8e-71 235.3 In-house 15-272 (280) alignment
Range on Protein: 650-911
Range on HMM: 15-272/280.0
GGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYI----DGFNRQKAYIATQGALKTTFDDFWRLVWEQKSV
|   |..|..     .   . .   ||  |||| .|..||. ||.|.      ..|||||||.    .. .  . |||||| |..|  |||..|||||| 
Gavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

VIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT
.|||.| | |||| || .||| ..   .| |..|..| ...  || || ..||....|.    ||.. .. |..|||||||  .  .|.|..|  ..  .
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke....erkilqlqylaWpdhgvPddsadflefvervrklrsg

DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLL
.  |..||||||.|||| .|...| |  ..|.|.|..   ....| ||  ||||..|| |. . .|
keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 635-928 1.6e-68 226.1 In-house 5-293 (439) alignment
Range on Protein: 635-928
Range on HMM: 5-293/439.0
SKFESHVIACHANSDGGFAAEYEEIQHVPTS--FPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTF
..|. ||   . | .  |  ..|.|. .       |.. ..  .. |||| .....| .|| || .||.| | |||||||.|.  .| ||||||  | | 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

DDFWRLVWEQKSVVIVMITKLEERGRrkcdrYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKvpERRVYHFHYTDWPDHGVPPYTLPV
|||||||.|.|.| |||.|.| |  .     |||...    | .. |  . . ..  |..| | .  .. .  |  || | .|||. |||. ||  .  |
ddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttek..ertvlqfhyiawpdknvpaqashv

LSFIQRS-SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQ
| |..   || .  . ||..|||||||||||| | .|  |.|...|.||.. | .| .| ||. .||.  |||||.. .|| .  |.. |   |...
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk

subfamily_PTPN13_pd Subfamily PTPN13 653-915 8.6e-68 223.5 In-house 14-270 (273) alignment
Range on Protein: 653-915
Range on HMM: 14-270/273.0
AAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGipnsdYINANYIDGF--NRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
| |..|.... .   .. . . ||| |||| |.. || .|| |.   |     ||||..|     . .  |||.|| | .| .|||..|||||. ||.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TKLEERGRRKCDRYWPAKGT--PERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPtDAG
|.  |.|. ||.|||| .       .| |||.|.  .|  ....|.. .|. .   |..  |.| |.....|||||||  ....| |...    .  |||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses..ges..revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dag

PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
||.||||||.||.||.|.||..|  .. .....|   ....| ||. .|||..||.|.. ..|| |.
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 632-922 4.5e-67 221.0 In-house 2-286 (287) alignment
Range on Protein: 632-922
Range on HMM: 2-286/287.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPT-SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQplpgIPNSDYINANYIDGFNRQKAYIATQGALKT
| ..||   |   ||... ||   .  ...|       | .   .|| |||.|.|. .|  || |.      . ||||| .|||.. .||.|.... .  
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHG-VPPYT
|  .||.|.....  .|||.....|  ...| .||| . .   . | ...|  .|. |.|. |.. .|...|.    ....|  ...|.|...| |. . 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkag...dkqqvkqyqitnWdstgkvtepq

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVK
  .| . ..  .      ..|.||||..|||..... ..| ... . |  ..||  ||. | |.   ||| ||| || |..|| | ...| ..
tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 653-923 7.8e-67 220.5 In-house 26-293 (297) alignment
Range on Protein: 653-923
Range on HMM: 26-293/297.0
AAEYEEIQHVPTS--FPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRqkAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
  ..||.. .|..  .|.| . .  |  |.||.||. |||||| |. .   |.|||.|| .. |..    .|.||   |.| .|||..|....  .|||.
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

TKLEERGRrKCDRYWPAKGTPErYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVperrVYHFHYTDWPDHGVPP--YTLPVLSFIQRSSAANPTDAG
....|| . || |||. ||. . . .. |.|.  ..   .  |.. ... . |  .|    |  .....|||. |.    .  .| .|.       . | 
nddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrv....vkqyqfveWPdkaverkdsassllklisevrkdfsqnae

-PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKS
 |..|||.||||||| .. || .. ... |..|..||..|..| .| |||||.||| |.. ..|| | . .| ...
gPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 633-925 2.1e-66 219.3 In-house 6-299 (325) alignment
Range on Protein: 633-925
Range on HMM: 6-299/325.0
HISKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTF
 . ..  ||   .|. . ||| |.. .  .  .   . .   ||| |||. |.|..| ||| |. .   |.||||||.|.  . ... ..|.|  | .| 
avvnlvehvekkkaqdqdgfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

DDFWRLVWEQKSVVIVMITKLEErGRRKCDRYWPAK-GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKvpERRVYHFHYTDWPDHGVPPYTLP
.|.|||| . .. |.|.. .|.. |  .|  ||| . |   ..  ||| |   |... |  | . .|  .|  |.   | |  |..  |.| ||. .   
ndlWrlvldWrcsvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk..Ge..trsvkqfqlqswddmGvqkrpat

VLSFIQRSS------AANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTE
..|..|          ||   ..||.|||||||||||..| . ..|...  | .|..|||.|..| .|  .|.| .||..|.. | | . .||| |  . 
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss





subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 672-915 2.7e-65 215.0 In-house 16-265 (270) alignment
Range on Protein: 672-915
Range on HMM: 16-265/270.0
SDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN-RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGT
. . .|  |||..|.    .|| |..|   ... ||||||. ||. ..|.|||..| |.||  .|||..||.|.  |||.|.|||.||.||.|||||.  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

P---ERYNELEVTLELKEKFASYTLRTFLLKhrhkKHGKvpERRVYHFHYTDWPDHGVPPYTL------PVLSFIQRS--SAANPTDAGPIIVHCSAGVG
     .. ...|. . .||   | |.   |.    ..|.  |||. ||.|..|||||||. .        .|. ..    |  .  .|.|..||||||||
ekvkledgkikvlalseekeegyiltrlrle....ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
|||| |..|.... .. ..||.|   ....| .|  |||. ||| |.. ...|. .
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_CG7180_pd Subfamily CG7180 674-914 1.9e-64 212.2 In-house 40-290 (296) alignment
Range on Protein: 674-914
Range on HMM: 40-290/296.0
VENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRrKCDRYWPAKGtPER
 ||. |||. ..| ||  || |. | |  .|||||| |.|.| ..|.|| |..  | | |.|||||.....  .|..||  .  . ..  ||| |.  |.
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keq

YNELEVTLELKEKFASYTLRTFLLKHR------HKKHGKVPERRVYHFHYTDWPD-HGVPPYTLPVLSFIQRSSAA-----NPTDAGPIIVHCSAGVGRT
| |..| .  ....|  . ||| |...      ..|. |...| | .|..| |.  . ||  |  .. ...|         .  . ||..|..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
| |. ||  | ... ||.|.||...|..| .|. ||.. |.| .| |||||..
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_PTPN14_pd Subfamily PTPN14 649-915 2.9e-63 208.6 In-house 22-297 (300) alignment
Range on Protein: 649-915
Range on HMM: 22-297/300.0
DGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIpNSDYINANYIDGF--NRQKAYIATQGALKTTFDDFWRLVWEQKSVV
.|   .|||.|..  .    . ..  ||. |||. ... |. .|| |.|     ...||||  |      ... ||..|| |..|  |||..||||.  .
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMITKLEERGRRKCDRYWPAKGT---PERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRS----
|||.|. || |. |. .|.| ..      .... .|| ...|.  |.. ... |||   |.    || |.|. ||||||||||.   . ||....     
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske....ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr

---SAAN-P-TDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
   .  . .     |..|||||||||||  |. | ... .. .|....   |.|.|.|| .||||  || |...||...|.
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_PTPN1_pd Subfamily PTPN1 652-913 2e-61 202.2 In-house 8-270 (290) alignment
Range on Protein: 652-913
Range on HMM: 8-270/290.0
FAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
... |..|..  . ||.. . . ||. .||| ..  || ||. |.      . |||||. ..  . .. || ||| |  | | ||..||||||  .||. 
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmln

KLEERGRRKCDRYWPAKGT-PER-YN--ELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQ--RSSAANPT
|. |... || .||| .    |  ..  .|.|.|  .|.   ||.|.. |. .. ..     | ..||||| ||| |||      |.|..  |.| .  .
kvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe....treilhfhyttwpdfgvpespaaflkflfkvresGslss

DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEK---VNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
| || ..|||||.||.||....||.| .......   |..   |  .| .|  |.|| .|  | .  .|| 
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 636-919 1e-60 200.0 In-house 4-298 (301) alignment
Range on Protein: 636-919
Range on HMM: 4-298/301.0
KFESHVIACHANSdggFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPG--IPNSDYINANYIDGFNRQKAYIATQGALKTTFD
. ..||.|.|.|.   |...|.|.... .. ..| . . |||  ||. ||. ||  |. |.| |   . . .||||.||||....|..||.|| .| |  
dlgthvaakhsnk...feeqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlv

DFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLK-----------HRHKKHGKVPERRVYHFHYTDWP
|||||.|..| | |||.|.|.|. . || .|||  . . |.. ...|||  .  . ....| . .|           .. |.. .   . |  .. ||||
dfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWp

DHGVPPYTLPVLSFIQRS-SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNT
..|| .    ||  |.    . .  . ||..||||..|.|.|.|. ..  | | .||  |.||.  |..| ..   |.| |||..|.||. ..|.  .|
qdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 652-931 1.1e-60 200.2 In-house 22-253 (392) alignment
Range on Protein: 652-931
Range on HMM: 22-253/392.0
FAAEYEEIQHvPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
|. |. ..   |  .| | .    |. |||| ||. |||.|| |. .  ||.|||.|| ||..|. .|||||.||   ...|||||.|....   |.|.|
ffeefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

KLEERGrrkcdrywpakgtperynelevtlelkekfasytlrtfllkhrhkkHGKvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPII
||.|                                                .|.   | |  ||.|.|||..|| .|  .| ||.  .|     . |.|
klkegd..............................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpli

VHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVD
.||||||||||  | ||... . .    |.|| |.  || .| |.|||.||| ||.  .|| |   ||..    . ....
ihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlq

0051299 (Phosphotyrosine protein) phosphatases II 917-1214 2.3e-59 196.6 In-house 1-283 (288) alignment
Range on Protein: 917-1214
Range on HMM: 1-283/288.0
GNTVVKSTELRQYVDRMTlpdEVGRVVLDEQFNLIMKMK-PRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVT
|.| .. .||...| ...     |   | |.|. ..... .... ...  . ..||| .|..| ..||| .| ..|   ..|||||...||......|.|
gdteisveellklvlkll...angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKEF--DDDDQL
|.|  .|.||||.|.||.|...||.||. .    |. . |||.  ...||.| .|.||..  .              .  |.. | ..|...   |.  .
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.............lddytvrtlevtnldlldgdgesr

NVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDY
.|...|.  ||| . |  .   .|.. .|.| ..        . ||. || . |   .|||.|| .|.. . .|. ||....|| .  .||..... | |
tvthfhytnwpdhgvpdspellldflrlvrkala.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy

YYLFKALQ
.....|| 
rfvyeall

0050432 (Phosphotyrosine protein) phosphatases II 939-1214 1.5e-58 194.0 In-house 39-296 (308) alignment
Range on Protein: 939-1214
Range on HMM: 39-296/308.0
VGRVVLDEQFNLIMKMKP-RDYEFSKARQSKHKNRDMDLIPVERSRVPIsgvPGVDGYINASFLQGY--RRQNEYIVTQYPSAETMEDFWKMLWEHNSTT
 ..  |.|.|. ....|| ..|....  . |.||| .| .| ..||| .   .. ..|||||. .||  ......|.||.|  .|.||||.|.||.|...
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVTLTDDQKED---EPIYWPTNVD-EPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKEFDddDQLNVRQYHCSYWPDCCSPL--HTAF
||.||. .  .    . |||.... ..|. | .|.||..  .              .  |.. | ..|.. .  . . |...|.  ||| . |      .
IvmLtklvengrekcaqYwplelgggsleygkftvtllseev.............lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeill

DLIYAVQKRNeflerSNketvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
|.. .|.|..     ..    ||| || . |   .|||.|| .|.. . .|  ||....||    .||. ... | |..|..||.
dflelvrksl.....pg....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

0046845 (Phosphotyrosine protein) phosphatases II 944-1215 8.1e-58 191.4 In-house 2-272 (284) alignment
Range on Protein: 944-1215
Range on HMM: 2-272/284.0
LDEQFNLIMKMKPR---DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV---DGYINASFLQGY-----RRQNEYIVTQYPSAETMEDFWKMLWEHN
|.|.|  ......    ....... . ..||| .|..| ..||| .. ..|    ..|||||...||     ......|.||.|  .|.||||.|.||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STTIVTLTDDQKED---EPIYWPTNvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefD-DDDQLNVRQYHCSYWPDCCSP--LH
...||.||.    .    . |||.. .|.||.| .|.||.....              .  |.. | ..|.  . ..  . |...|.  ||| . |  . 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.............kddytvrtleltnl..gytgesrtvthfhytswpdhgvppspe

TAFDLIYAVQKRNEFlersnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEE---AVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
  .... .|.. .|       .. ||| ||.. |   .|||.|| .|.. ...|.    ||....|| .  .||. ... | |.....||. 
dlleflrlvrellen.....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle

subfamily_PTPN23_pd Subfamily PTPN23 647-915 1.1e-57 190.1 In-house 12-281 (288) alignment
Range on Protein: 647-915
Range on HMM: 12-281/288.0
NSDGGFAAEYEEIQHVPTSFPATFSSDV--ENKLKNRYTNIVSYDSSRVSLQplpgIPNSDYINANYIDGFNRQ-KAYIATQGALKTTFDDFWRLVWEQK
.  ... ....|...        .|  .   .  |||...|. ||..|| |.      . ||||| .. .   .   .||||. |..|  |||..|.|||
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SVVIVMITKLEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA-
| ||||... ||.|. |.|||||. || ......|.|||. ...   .  |.. |.......     . | | ..| ||..|||     .| |..   . 
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldada....vksvshlqltsWpelGvPasPetllqfldevesa

----ANPTDAgPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKV-NVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
     ..... |..|||||||||||.. .. . ........ . ..   ..|.|.|| . ||..||. |  .. ||  |
yeavqrkskt.PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

0047943 (Phosphotyrosine protein) phosphatases II 939-1213 8.5e-57 188.0 In-house 9-268 (273) alignment
Range on Protein: 939-1213
Range on HMM: 9-268/273.0
VGRVVLDEQFNLIMKMK-PRDYEFSKARQSKHKNRDMDLIPVERSRVPIsGVPGvDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIV
 |. .| |.|.|....| . .|....  . |.||| .|..|...||| . | .| ..|||||...||......|.||.|  .|.||||.|.||.|...||
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdgg.sdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

TLTDDQKE---DEPIYWPTNVDE-PLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKEFDDddQLNVRQYHCSYWPDCCSP--LHTAFDL
.||...     . . |||....| .|| | .|.||.. .|              .  |.. | ..|.....   . |...|.  ||| . |  |   ...
mLtelvelgrekcaqYwpleggelsltygkftvtllseet.............kddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllef

IYAVQKRNEFLERSnketvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
| .|.| .| | ..     ||. || . |   .|||.|| .|.. ...|  ||....|||.  .||. ... | |..| .||
ielvrkalealpsn.....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 658-926 1.8e-56 186.1 In-house 14-278 (283) alignment
Range on Protein: 658-926
Range on HMM: 14-278/283.0
EIQH--VPtSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGipnsDYINANYID---GFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITK
 ...  || . .|. .|  ||| |||. .||..|  || |....     ||||| .|      ...| ||..|. |. |  |||..|...| . |||.||
vlkrlsvp.dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

LEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPerrVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIV
| |  | || .||| .|. | | |. |||.      |.. . .||..    . ..    . |. . || . |  .    .. | .  |  .    |||.|
lqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstll...lahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTEL
|||.|.|||...| . . .|....|  |.||  .| .| ||  .||| .|| ..|.. ||   .|.| .   .|
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl

subfamily_PTPRD_pd Subfamily PTPRD 943-1227 5.2e-56 185.4 In-house 24-294 (564) alignment
Range on Protein: 943-1227
Range on HMM: 24-294/564.0
VLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT
 ..|... | . .    | ... . |.|||  . .. ..||| .| |.|..|  ||||||..|||....|| || | |||.||||.|.||.||.||| ||
kfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

DDQKEDE---PIYWPTNvDePLTLGALTITLWKRNTLISPSSQGKFLgQSSQgthtplviqnkefdDDDQLNVRQYHCSYWPDCCSPLHTaFDLIYAVQK
  . ...     |||.. . . | | ||.|| . ..|   .    .| . ..              .... .|||.|   ||| . | ..  .|.  ..|
kleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkk..............ssesreVrqFhFtsWPdhgvpesa.tslLdlirk

---RNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ---SCHSAELQIRSLR
    ||       .. |||.||  .|    |||.... . . . .|. ||||..||.  ..|. .. ..| | ....|..   .| . |.....|.
vralne.......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlk

0040438 (Phosphotyrosine protein) phosphatases II 941-1215 1.1e-55 184.5 In-house 17-274 (317) alignment
Range on Protein: 941-1215
Range on HMM: 17-274/317.0
RVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVT
  .| |.|. ....|. .|....  ..|.||| .| .| ..||| .| ..|.  ..|||||. .|.......|.||.|  .|.||||.|.||...|.||.
ftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LTDDQ---KEDEPIYWPTnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIY
||.     .|    |||.  .|.|| | .|.||..  .              .  |.. | ....  .|.... |...|.  ||| . |  . . .|.. 
LteleelgrekcaqYwpl..getltygdftvtllseee.............lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfle

AVQKRNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
||.. .|       .  ||. ||   |   .|||.|. .... . .|. ||....|| . ..||. ... | |..| .||. 
avreale.......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle

subfamily_PTPRN_pd Subfamily PTPRN 671-910 4.8e-55 181.4 In-house 51-288 (297) alignment
Range on Protein: 671-910
Range on HMM: 51-288/297.0
SSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYI-DGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG
... .|  |||......|| |||.|.      .||||||  | |   |. ||||||| | .|  |||..|||| .||||..|.||| | ..|.|||| .|
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG

TpERYNELEVTLELKEKFA-SYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVID
. | |.  || |  .  ..  | .|.| ||  ....     | |  ||.  ||..|||. . ..| | ..   .    . ||.||||.|.||||.||.||
s.evyhiyevhlvsehiwcddylvrsfylknlqtse....trtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

TMLKQMQA-EEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVL
 .|....    ....   |. .| ||. ||.|..|. |.  ..
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

0051429 (Phosphotyrosine protein) phosphatases II 701-916 5.2e-55 182.2 In-house 1-227 (272) alignment
Range on Protein: 701-916
Range on HMM: 1-227/272.0
IPNSDYINANYIDGFNR---QKAYIATQGALKTTFDDFWRLvWEQKSVVIVMITKLEERGRRKCDRYWP-----------AKGTPERYNELEVTLELKEK
.| |.||||....|..|    .......| |. | .||||| .|..  .||.....||||| |||||||              .. .|. | |||  .| 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

FASYTLRTFLLKHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYTlpVLSFIQRSSAanptdAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVN-----
.  |.||..||.. .. .     |.|.|.|||||||||||. .  .|....   .      ||..||||||..||||..... .| .. .|  |.     
lldyilrellltlllsagea...revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRA
   ........| || . |||||||.|....|||.||.
nlyleeaveelraqrpgavqteeqylflyeallellrs

0036941 (Phosphotyrosine protein) phosphatases II 951-1214 2.1e-54 180.2 In-house 23-274 (297) alignment
Range on Protein: 951-1214
Range on HMM: 23-274/297.0
IMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPIsgVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---KEDE
   ... ... ..  . ..||| .| .| ...|| .   .. ..|||||...||......|.||.|  .|.||||.|.||.|.|.||.||..    .|  
lpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

PIYWPTNVDEPLTLGALTITLWKRNTLispssqgkflgQSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEFLERS
. |||....|.|| | .|.|| . ..             ..  | . | ....  ...... |...|.  ||| . |    . .|.| .|.|... | ..
aqywpleegesltygdftvtllsvevv...........llddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

nketvGPITVHDRSGGCQAGTFCALSTLHQEMI---HEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
     ||. || . |   .|||.|. ...| .    .|. |||...|| .  .||. ... | |..|  ||.
.....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

0043336 (Phosphotyrosine protein) phosphatases II 927-1213 4.3e-54 179.2 In-house 5-273 (278) alignment
Range on Protein: 927-1213
Range on HMM: 5-273/278.0
RQYVDRMTLPDEVGRVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDF
 ......  .   .. .| ..|  ....|. .|....  ..|.||| .| .| ..||| .| ..|.  ..|||||.. ||......|.||.|. ||.|||
kdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WKMLWEHNSTTIVTLTDDQ---KEDEPIYWPtnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNkeFDDDDQLNVRQYHCSYWPDC
|.|.||...||||.||..    ..    |||   ...|| | .|.||.| ..              .  |.. | . |    |.  . |..||.  ||| 
wrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.............lddytvrtlevtn..lgdgesrtvthyhylgwpdh

CSP--LHTAFDLIYAVQKRNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
. |  | . .|.. ||....|          ||. || . |   .|||.|| .|.. . .|  ||....|| .  .||. ... . |..|..||
gvpeslsllldflkavreale.......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

DSPc_SM00195 944-1215 3.5e-53 176.0 In-house 2-260 (263) alignment
Range on Protein: 944-1215
Range on HMM: 2-260/263.0
LDEQFNLIMKMKPRDyEFSKARQSK--HKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
|.|.|. ...... . |...|...|  .|||  . .|....|| ..  ..   . ||||....|......||.||.|  .|.||||.| ||.....||.|
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TDDQK---EDEPIYWPTNVDEPLTLGALTITLWKRNTLIspssqgkflgqsSQGTHTPLVIQNKEFddDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYA
|....   |    ||| . ... | | ....|.. ..              .. . . | .....   ... .|.||..  |||   |   .  ..|. |
teeeengkekcdrywpeesggketfgkisvklvevekkk............deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellra

VQKRNEFLersnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|.|...          ||| ||   |  ..|||...... ... .|. ||| ..||    .||......| | .. .|.  
vkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 944-1215 3.5e-53 176.0 In-house 2-260 (263) alignment
Range on Protein: 944-1215
Range on HMM: 2-260/263.0
LDEQFNLIMKMKPRDyEFSKARQSK--HKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
|.|.|. ...... . |...|...|  .|||  . .|....|| ..  ..   . ||||....|......||.||.|  .|.||||.| ||.....||.|
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TDDQK---EDEPIYWPTNVDEPLTLGALTITLWKRNTLIspssqgkflgqsSQGTHTPLVIQNKEFddDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYA
|....   |    ||| . ... | | ....|.. ..              .. . . | .....   ... .|.||..  |||   |   .  ..|. |
teeeengkekcdrywpeesggketfgkisvklvevekkk............deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellra

VQKRNEFLersnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|.|...          ||| ||   |  ..|||...... ... .|. ||| ..||    .||......| | .. .|.  
vkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0039614 (Phosphotyrosine protein) phosphatases II 940-1214 6.5e-53 175.5 In-house 30-286 (297) alignment
Range on Protein: 940-1214
Range on HMM: 30-286/297.0
GRVVLDEQFNLIMKMKPrDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV---DGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTT
.. .|...|  ....|| ||....  ..|.||| .| .| ..||| .....||   . |||||...||.. ....|.||.|. ||.||||.|.||...|.
sktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtv

IVTLTDDQKED--EPIYWPTNVDeplTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNkefdDDDQLNVRQYHCSYWPDCCSP--LHTAFDL
||.||.    .   . |||....   | | .|.|| |  .              .  |.. | ..|    ..  . |.....  ||| . |  | . ...
ivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.............ldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslelllef

IYAVQKRNEFLersN-KetvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
. .|..... |   . .   ||. ||   |   .|||.|. .... . .|  ||....|| .  .||. ... . |..|..||.
lelvrealael...pkg...gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

0041856 (Phosphotyrosine protein) phosphatases II 676-921 2.3e-52 172.6 In-house 1-178 (182) alignment
Range on Protein: 676-921
Range on HMM: 1-178/182.0
NKLKNRYTNIVSYDSSRvslqplpgipNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITkleergrrkCDRYWPakgtperyn
|. ||||..|. || ||          ..||||||...|  ... .||||| |. |. ||.|...|..  .||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

elevtlelkekfasytlrtfllkhrhkkhgKVPERRVYHFHYTDWPDHGVPPyTLPVLSFIQRSSAanptDAGPIIVHCSAGVGRTGTYIVIDTMLKQmq
                              .  || .....|. |||||||. .  .|.||..  .    . ||..||||||||||||..... |.|.  
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl..

aeeKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVV
   .|...  .| .| .|.  |.|..||.|....|||.|. ..|..
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 653-914 3.3e-52 172.0 In-house 13-277 (287) alignment
Range on Protein: 653-914
Range on HMM: 13-277/287.0
AAEYEEIQHVPTSFPATFS--SDVENKLKNRYTNIVSYDSSRVSLQPLPGIpNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
 .|.. ...   | .|||    .. .  ||||.... .| .|| |   .    ||||||||. ......|.||.|| . .|  ||||.|.|..| .....
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

TKLEERGRRKCDRYWPAKGTPERYNELEVT-LELKEKFASYTLRTFLLKHRHKKHGKVperrVYHFHYTDWPDHGVPPYTLPVLSFIQRS-----SAANP
|.  | .| || .||| .  | |     |. |. . |   |. |.. | . . .. .|    |  ... .|||....| .. .. |.         | . 
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearv....vkqldllswPdkvlaPtavglirfvldvkqhielarda

TDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
...||..||...|.||.|... . .......   .|.|   . |.| .|. |||.  |. .. . |  . 
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

0045450 (Phosphotyrosine protein) phosphatases II 943-1213 1.1e-51 171.7 In-house 28-300 (307) alignment
Range on Protein: 943-1213
Range on HMM: 28-300/307.0
VLDEQFNLIMKMKP---RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV---DGYINASFL--------QGYRRQNEYIVTQYPSAETMEDFWKML
 | ..|. ......    .|....  ..|.||| .| .| ...|| .| ..|    ..|||||.         .||......|.||.|  ||.||||.||
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEHNSTTIVTLTDDQKEDEP---IYWPTNvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKeFDDDDQLNVRQYHCSYWPDCCSP-
||...|.||.||..   . .    |||.. .|.|| | .|.||.. ..              .  |.. | ....   ..  . |...|.  ||| . | 
weqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.............ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvpp

-LHTAFDLIYAVQKRNEFLERSnketvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEA---VDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 . ...|.| .|.| .| | ..     ||. || . |   .|||.|. .. . . .|.    ||....|||. ..||. ... | |..| .||
sfeelldfieevrkaleelpkg.....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 650-913 5.5e-50 164.8 In-house 6-258 (267) alignment
Range on Protein: 650-913
Range on HMM: 6-258/267.0
GGFAAEYEEIQHVPTSFPA-TFSSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIV
  .  |.|.|... .     . |   .|. .||. . . || .|| |.      . .|||| |..|.....|.|.||..|| |  ||. .. .||  |||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MITKLeerGRRKCDRYWPAK-GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVperrvYHFHYTDWP-DHGVPPYTLPVLSFIQRSSAANptD
..||    .  .  ..|| | |  ..|..| |   |...   | . |. || . .   .|       ..|  |  .    ||  |..  . .    |   
lltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnv.....tlyyykkwnintnnkpylkplfgilaknqlen..g

AGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
  |..|.||.||||.||..|||..|.... |. ...| ||..|| ||  ||.| |.|..||..| |.
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

Y_phosphatase Protein-tyrosine phosphatase 968-1214 6.4e-50 165.1 Pfam-A 2-234 (235) alignment
Range on Protein: 968-1214
Range on HMM: 2-234/235.0
KHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLTLGAL
|.|||  | .| ...|| ..| .|   ||||....||......|.|| |  .|.||||.|.|......||.||....   |  . |||.. .|.|| | .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TITLWkrntlispssqGKFLGQSSQGTHTPLVIQN----KefdddDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNeflersnKETVGPITVHDR
...|             |   .... | . | ...    .     ..  |.|.|.  ||| . |   .  .||| .|.|..       ... ||..||  
kvelk...........ekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCs

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 |  ..|||.||..| ... .|| ||....||   ..||....| | |..| ||..
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 968-1214 6.4e-50 165.1 In-house 2-234 (235) alignment
Range on Protein: 968-1214
Range on HMM: 2-234/235.0
KHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLTLGAL
|.|||  | .| ...|| ..| .|   ||||....||......|.|| |  .|.||||.|.|......||.||....   |  . |||.. .|.|| | .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TITLWkrntlispssqGKFLGQSSQGTHTPLVIQN----KefdddDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNeflersnKETVGPITVHDR
...|             |   .... | . | ...    .     ..  |.|.|.  ||| . |   .  .||| .|.|..       ... ||..||  
kvelk...........ekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCs

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 |  ..|||.||..| ... .|| ||....||   ..||....| | |..| ||..
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0045098 (Phosphotyrosine protein) phosphatases II 943-1215 4e-48 159.6 In-house 10-270 (278) alignment
Range on Protein: 943-1215
Range on HMM: 10-270/278.0
VLDEQFNLIMKMkPRDYEFSKARQSKHKNRDMDLIPVERSRVPisgvpgvdGYINASFLQGYrrQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD-
 |. .|.|..   | .....  . ...||| .| .|...|||         .|||||...||  ....|.||.|  .|..|||.||||...|.||.||. 
llefefllllgi.pseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

--DQKEDEPIYWPTnvDEPLTLGALTITLWKRNTLispssqgkflgqsSQGTHTPLVIQNK--EFDDDDQLNVRQYHCSYWPDCCSPLHTAF-DLIYAVQ
  ...|  . |||   ...|| | .|.||..  .|             .  |.. | ..|   |. |. ...|...|.  ||| ..| ..    .. ...
velgrekcaqywpe..ggsltygdftvtllseevl.............ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle

KRNEFLER-------------SNketvGPITVHDRSGGCQAGTFCALSTLHQEMihEEAVDIYKTVKLYAAKRPN-LITSREDYYYLFKALQS
  .|.|..             |.    ||. || . |   .||..|. .. . .  |. ||....|| .  .||.  ... | |..|...|. 
firealkllaslllsslllldsg....gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 926-1227 4.1e-48 159.1 In-house 7-293 (318) alignment
Range on Protein: 926-1227
Range on HMM: 7-293/318.0
LRQYVDRMTLpdeVGRVVLDEQFNLIMKMKPRDYEF-SKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETME
|.. | |.      |...|.|... . . .    .. |     |.||| ..... ...|| .. . |. |  ||||....||||...|| .| | .||.|
leshvrrlre...sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWKMLWEHNSTTIVTLTDDQ---KEDEPIYWPTnvDEPLTLGALTITLWKRNTLispssqgkflgqsSQGTHTPLVIQNKEFddDDQLNVRQYHCSYWP
|||.|.|| ||..||.||. .   |.    |||   ... ..|.|...| .. .|             |. .   . ....|   ... .|||||.  ||
DfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevel.............sdyvlrefkvtrtee..eesrqvrqyhytsWp

DCCSPLHTaFDLIYAVQKRNEFlerSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC-HS
|  .| ..  .|.  |.. ..     .|...|||.||  .|  ..|.|.|...| . . .|. ||...|||    .|. ..  .. | .....|.   .|
degvpesg.aslldlvrqvska...qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

--AELQIRSLR
  .| . . ||
gdtevdasdlr

0040439 (Phosphotyrosine protein) phosphatases II 958-1213 6.1e-48 159.0 In-house 2-242 (249) alignment
Range on Protein: 958-1213
Range on HMM: 2-242/249.0
DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---KEDEPIYWP
.|....   .|.||| .| .| ..||| .| .||   ..|||||.. ||......|.||.|  ||.||||.||||...|.||.||...   .|.   |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEFLersN-Ket
.  ...|. | .|.||.. ..             ..  |.. | ..|.   |.. . |.....  |||   |  . ...|.| ||.| .| |   . .  
l..ggsleygdftvtllsvev.............kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...pkg..

vGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ||. ||   |   .|||.|. .... . .|  ||.. .|||.  .||. ... | |..| .||
.gpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

subfamily_PTPRA_pd Subfamily PTPRA 958-1227 1.4e-47 157.2 In-house 49-308 (330) alignment
Range on Protein: 958-1227
Range on HMM: 49-308/330.0
DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWP
 .| ..  . |.||| ....| . ||| .| . ||.   ||||||..||......| .| | .||.||||.|.||..|.||| ||. .. .|     |||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

TnvDEPLTLGALTITLWKRNTLISpSSQGKFLGQsSQGTHTplviqnkefDDDDQLNVRQYHCSYWPDCCSPLHT--AFDLIYAVQKRneflersNKETV
.  .  .| | ..... . . |..  .  ||| |  .. .|         .....  |||.|   |||   | ..   ..|. .|.|        |. . 
d..eGlvtyGnirvevedetvlvd.ytvrkflvq.qlpdat.........rekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl.......nqqsa

GPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC---HSAELQIRSLR
|||.||  .|  ..|||..|... . .  |. ||....||   ..||... . | | ...|.|.       .||.. || 
gpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

0036282 (Phosphotyrosine protein) phosphatases II 704-908 1.5e-47 156.8 In-house 2-164 (174) alignment
Range on Protein: 704-908
Range on HMM: 2-164/174.0
SDYINANYIDGFNRQKAYIATQGALKttfddFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkgtperynelevtlelkekfasytlrtfllkhrhkk
||||||...|.. . . .||.|| |.     ||....|... ..|| ....|.|. || .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

HGKVPERRVYHFHYTDWPDHGVPPYTLpVLSFIQRSSAANPT-DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQaEEKVNVFGFLKRIRTQRNYLVQTEEQ
. . .|| .....|. |||||||. .  .|.|...   |    . ||..|||||||||||| .... ||...  |  |... .....|.|| . |||..|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YVFIHD
| |...
yrflyy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 657-914 2.9e-47 156.2 In-house 20-277 (307) alignment
Range on Protein: 657-914
Range on HMM: 20-277/307.0
EEIQHVPTSFPATFS--SDVENKLKNRYTNIVSYDSSRVSLQpLPGIpNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLE
.|.. .    | . .  .   |  ||||...   | .|. .. ..|.  |||| |||.    . | .|..|| |..|  .|| .. ..|   ..|. |. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

ERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYT--LRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQrssAANpTDAGPII
| .. ||..|||. .|    . |   |. ...  |        ..     |       | . |. ...|||.|||.  |  . ...   | .  |  |..
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle...avr.ydtnpvv

VHCSAGVGRTGTYIVIDTML-KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|||||||||.|| . |  .  | .. ..  ..  ... .|.||.| .||| ||...| ||||..
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0049772 (Phosphotyrosine protein) phosphatases II 662-921 4.1e-47 156.8 In-house 32-287 (314) alignment
Range on Protein: 662-921
Range on HMM: 32-287/314.0
VPTSFPATFSSDVENKLKNRYTNIVSYDsSRVSLqPLPGIPNSDYINANYIDGFnrqKAYIATQGALKTTFDDF----------WRLV--WEQKSVVIVM
|....  .......|. ||||..|. .| .|| | |  .. .||||||.|.|||   ...||||| |. |..||          ||.|  ..... .|||
vlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITKLEERGrrkcdrywpAKGTPERYNELEvtlelkekfasytlrtfllkhrhKKH--GKVPERRVYHFHYTDWPDHGVP
                     ...| ..|         .  |.... .|.                       . .  .. .||..........||...|
srdevladelsrLdaAlgKtpllildgng.........neptaadlellk.......................eelydpelferlgikylripvpDgsap

--PYTLPVLSFIQRSsaanpTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMqaeeKVNVFGFLKRIRTQRN-----YLVQTEEQYVFIHDVLLEWLRAGNT
   . . .| ||..       . ||..|||.||.|||||..|.. ..|..    .|..   |...| .|       .... |||.||...|||.|.   .
lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk

VV
. 
fy

0042113 (Phosphotyrosine protein) phosphatases II 960-1214 1.7e-46 154.0 In-house 2-240 (245) alignment
Range on Protein: 960-1214
Range on HMM: 2-240/245.0
EFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTn
....   .|.||| .| .| ...|| .| ..|   ..|||||.  |||. . .|.||.|..|| ||||.||||...||||.||..     .. . |||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

vDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEFlersN-KetvG
 .|.|| | .|.||.. ..              .  |.. | ..|.   || ...|..||.  ||| . |  | . .|.. .|.|  .     . .   |
.gesltygdftvtllseeh.............lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsn...g

PITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
|. || . |   .|||.|. .... . .|  |.....|| .  .||. ... . |..| .||.
pvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 917-1215 2.4e-46 153.3 In-house 1-288 (298) alignment
Range on Protein: 917-1215
Range on HMM: 1-288/298.0
GNTVVKSTELRQYVDRMTL-PDEVGRVVLDEQFNLIMKMKP----RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNE
||| .....|.. . ...    . . ......|. . ...       .| ..... |.||| .|.|... ||| .. . .     |||||||..|...| 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEplTLGALTItlwkrntlispssqgKFLGQSSQGTHTPLVIQNKEFDDDD
.|.||.|  ||.||||.|..|....||| ||. .  |.   . |||..  |  | | .|.               . | . ...  .   .. .. . ..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitv...............sllskeefadlivrklkvskkkeek

QLNVRQYHCSYWPDCCSPLHTA--FDLIYAVQKrnefLERSNKEtvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSRE
. .||| | . ||| . | ..   .||.  |..     .. ...   |..|.  .|   .|||.|.... . . .|. ||....||   .|||......|
erevrqlhftsWpdkgvpenatsvldllrkvra....sqqqagn..kpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

DYYYLFKALQS
.| ....| . 
qYvfiyeavle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 630-913 8.8e-46 150.8 In-house 7-282 (290) alignment
Range on Protein: 630-913
Range on HMM: 7-282/290.0
PAIHISKFESHVIACHANSDGGFAAEYEE-IQ-HVPTSFPATFSSDVEN-KLKNRYTNIVSYDSSRVSLQPlpGIpNSDYINANYIDGFNrqKAYIATQG
 ...   ||         .  ..| || | .. ..|. .      | .    |||| ..|  | .|| |.   |  . ||. |||..| .    .| |||
hsvqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gy.dGdyvhanyvkGlk..amfiltqG

ALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEKFASYTLRTfLLKHRHKKHGKvpERRVYHFHYTDWPDHGV
||| |  |.||.| ..|  .|||. .| | |. ||..|.| | |    . |. |.  ....  . . .  .|  |.|. ||  | ...|..   |||. |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikk.tlsvrdkdsGk..ehklkhlkikswpdksv

PPYTLPVLSFIQRSSaanpTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
.  || .|  ..       . .||..||||||.|||||.. |.. |. .    .... .  . .|  |   || . ||. . ..||..
alstlallrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 673-917 2.7e-45 149.4 In-house 45-290 (305) alignment
Range on Protein: 673-917
Range on HMM: 45-290/305.0
DVENKLKNRYTNIVSYDSSRVSLQPlpGIPnSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPE
. ... |||| ..   |  || |..    |  .|| |||.      | .| ||  |. |  ||| . ...|   | |. .| |.| .||  |...|  ..
eaqeagknrykdvgcldnnrvkleg..pwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

-RYNELEVTLELKekFASYTLRTFLL-------KHRHKKHG-KVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAAnptdAGPIIVHCSAGVGRTGT
  ..| .  . .|  | | .   |         .      |     |.| |.|. |||| |||.  | .| ..... ..     |||.||||||.||||.
lefeekgqkisvk..fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgs

YIVIDTMLKQMQAEEKVNV-FGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
 .... .|.|. | ....     |..|| |||  .||..||.|.|.|.|...|  
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 923-1227 2.6e-44 146.6 In-house 7-296 (319) alignment
Range on Protein: 923-1227
Range on HMM: 7-296/319.0
STELRQYVDRMTLpdeVGRVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAET
  ||.... ..      |   |...|.|. . .. ... ..  . |.|||  ......|.|| .| ..||.|  ||||||..||......| || | ..|
vqeLkerlkalas...tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

MEDFWKMLWEHNSTTIVTLTDDQKEDEPI---YWPTnvDEPLTLGALTITLWKRNTLispssqGKFLgqssqgtHTPLVIqNKEFDDDDQLNVRQYHCSY
.||||.|.||..| ..| ||... . .     |||.   .. . | |..|| ... |       ..           | . ||  .. .  .| ...   
iedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeel......edyi.......irklkl.nkkssevetRevkhfqyte

WPDCCSPLHTA--FDLIYAVQKrnefleRSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|||   | ..    ||.  ..|        .|.. |||.||   |    |||..|.   . . .|...|...||.   ..|. ..   | | ....||  
WpdhdvPekatslldllkrirk......srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle

---CHSAELQIRSLR
   . ..|.... ||
aveagdteievqdlr

subfamily_Ptp69D_pd Subfamily Ptp69D 949-1218 1.5e-43 144.1 In-house 30-287 (307) alignment
Range on Protein: 949-1218
Range on HMM: 30-287/307.0
NLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED
.|  .. ... ..|.    . |||  |... .. || .. ..| .   ||||||..||. ....|. | |  .|..|||.|..| ..|.|| |.. .  .
kLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltekn

E---PIYWPTNvdEPLTLGALTITLwkrntlISPSSQGKFLGQSSQGTHtplvIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTaFDLIYAVQKRNEFLE
.   . ||| .  .    | . ..|      .| ......  .. . ..    ....  . .|. .| |||   |.|   | ..   |.  ... .|  .
rkkcakYWpie..devqygdilvkl......vseekhsdyiiReldvsk....kkeesgevedsrkvvqyhytgWkDskvPeva.rgllklieqvrelyk

RSnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHS
 .     .||.|| . |  ..|.| ||. | |..  |. |||..|||    .|. |..| | | .|..||   .|
ln....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

0043147 (Phosphotyrosine protein) phosphatases II 702-907 1.8e-42 140.3 In-house 3-154 (172) alignment
Range on Protein: 702-907
Range on HMM: 3-154/172.0
PNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLeergrrkcdrywpakgtperynelevtlelkekfasytlrtfllkhrh
..||||||.|.|.    . .||||| |  |..||||...|..  .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

KKHGKVPERRVYHFHYTDWPDHGVPpYTLPVLSFIQRSSA-ANPTDAGPIIVHCSAGVGRTGTYIVIDTMLkqmqaeEKVNVFGFLKRIRTQRNYLVQTE
 . ..  || .....|. |||||||  .  .|.|..     ..  . ||..|||||||||||| .... ||      ......  .. .|..|.. ||..
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

EQYVFIH
.|| |..
sqyrfly

0049260 (Phosphotyrosine protein) phosphatases II 711-908 2e-42 139.8 In-house 1-144 (152) alignment
Range on Protein: 711-908
Range on HMM: 1-144/152.0
YIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWpakgtperynelevtlelkekfasytlrtfllkhrhkkhgkvper
.|||.......||||| .  |..||||...|..  .|||.|.|.|.|. ||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rvyHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLkqmqaeEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
   ..... |||||||. .  .| ...    ..  . ||..||||||||||||..... ||       .|... .....|..|.. |....|. |...
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

0046846 (Phosphotyrosine protein) phosphatases II 696-914 3.8e-42 139.3 In-house 4-173 (176) alignment
Range on Protein: 696-914
Range on HMM: 4-173/176.0
QPLPGIPNSDYINANYIDGFnrqkAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERynelevtlelkekfasytlrtf
..|   ...||||||.|.|     ..||||| |  |. ||.....|..  ..|..|.. | || ||..|||   ...                       
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

llkhrhkkhgkvperrvyHFHYTDWPDHGVPPYtLPVLSFIQRSSAANPTDaGPIIVHCSAGVGRTGTYIVIDtmlkQMQAEEKVNVFGFLKRIRTQRN-
                  ......|||||||..   .|....    |   . ||..||||||.|||||.....     .. |  ..|.  |...| ||  
..................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

YLVQTEEQYVFIHDVLLEWL
. |||.||| |.....|..|
gavqtpeQyrflyefellll

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 662-914 4.3e-42 138.8 In-house 42-289 (305) alignment
Range on Protein: 662-914
Range on HMM: 42-289/305.0
VPTSFPATFSSDVeNKLKNRYTNIVSYDSSRVSLQPLPgipNSDYINANYIDG-FNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRK
  . | |  |.|. .. ||||...   | | | |.  .    |||| |||.   .  .| .|..|| |  | |.|| .| ..|   |||. |  | |. |
tqvafnanqsadi.aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

CDRYWPAKGTPERYNELEVTLEL-K---EKFASYTLRTFLLKHrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIqrsSAANpTDAGPIIVHCSA
| .||||     .     . .|             ..  ||.     .    .  | |...|.||| ||||  |  | ..   ||       ||.|||||
caqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnl...tysgdqkmsvrhlqwtewpdrgvppckltslell...sair.gskvpivvhcsa

GVGRTGTYIVIDTMLKQMQAEEKVN-VFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|.||||| . |. .|...  . ..  .  ..| .| || . .|.. ||.||| |.|...
gigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

0037934 (Phosphotyrosine protein) phosphatases II 961-1214 4.7e-42 139.6 In-house 4-239 (243) alignment
Range on Protein: 961-1214
Range on HMM: 4-239/243.0
FSKARQSKHKNRDMDLIPVERSRVPIsgvPGvDGYINASFLQGYRRqneYIVTQYPSAETMED----FWKMLWEHNSTTIVTLTDDQ---KEDEPIYWPt
...  ....||| .| .| ..||| .   .| ..||||.. ....|   .|.||.|  || ||    ||.||||...|.||.||...   .|. . ||| 
iallpenlsknrysdilpydhsrvkl...eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

nvDEPlTLGALTITLWKRNtlispssqgkflgQSSQGTHTPLVIQNkeFD-DDDQLNVRQYHCSYWPDCCSPLHtAFDLIYAVQKRNEFLER-----SNK
  .|  | | .|.||.. .             . .. |.. |...|   | || ...|..||.  ||| . | .   ||.  ... .||.|.      ..
..gev.tygdftvtllsee.............hlddytvrtlllen..ldlddltrlvihyhylpwpdhgvPds.pedlldfldevrefieellsllald

-EtvGPITVHDRSGGCQAGTFCALSTLHQEMiheeAVDIYKTVKLYAAKRPN-LITSREDYYYLFKALQ
 .  ||. || . |   .||..|. .... .     ||....|||. ..||.  ..... |..| .||.
sg..gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 957-1217 7.3e-42 138.8 In-house 51-291 (319) alignment
Range on Protein: 957-1217
Range on HMM: 51-291/319.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTddqKEDEPIYWPTN
 | .|.   | | ||| ..... ....| .  . |...  ||||||..||.|.. || .| |  .|..|||.|.||.|..||| ||   |.    ||| .
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplk

VDEPLTLGALTITLWKRNTLispssqgkflgqssqgthtpL-----VIQNkEFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQKRNEFLERSNkeT
...    . . ... .                               . . .    |. ...|.|   |||   | . . ||.  |.| . . .. |   
ivikeerfkvkvdsveetae....................yvvrdielse.dgkekdirkitqfhflGwpdvGvp.dypsdlmrlvkkvrhltsken..h

VGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCH
  .| ||  .|  ..|.. .| .| . | .|. ||.|..|.    .|..|. .  .|.... ||   |
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 957-1217 1.1e-41 138.2 In-house 15-255 (284) alignment
Range on Protein: 957-1217
Range on HMM: 15-255/284.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTddqKEDEPIYWPTN
 | .|.   | | ||| ..... ....| .  . |...  ||||||..||.|.. || || |  .|..|||.|.||.|..||| ||   |.    ||| .
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplk

VDEPLTLGALTITLWKRNTLispssqgkflgqssqgtH--TPLVIQNkEFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQKRNEFLERSNkeTVGP
...    . . ... .                     .    . . . .    |. ..||.|   |||   | . . ||.  |.| . . .. |     .
ivikeerfkvkvdsveesee.................yvvrdielse.dgkekdirkirqfhflgwpdvgvp.dypsdlmrlvkkvrhltsken..hran

ITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCH
| ||  .|  ..|.. .| .| . | .|. ||.|..|.    .|..|. .  .|.... ||   |
ivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_PTPRK_pd Subfamily PTPRK 959-1223 2.9e-41 136.3 In-house 35-284 (314) alignment
Range on Protein: 959-1223
Range on HMM: 35-284/314.0
YEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED---EPIYWPT
.. .|  . ..||| .|... .|||| .  . |     ||||... .|.| ...||||.|  ||..|||......|...|| ||. ...       ||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

NVDEpltLGALTITLWKRNTLISPSSQGKFLGQssqgthtplviqnKEFDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQKrnefLERSNKETVGPI
. .     | . ..| . ..|    ..   . .              .   ...  |||..   |||   | .    |.  |..    .. |..|. |.|
dtev...ygdikvelvetellaelvvrifrvek.............largqeeirevrqfqflgWpdhdvPvsat.gllklvrr....vkksqeeeaGri

TVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA-LQSCHSAELQI
 ||  .|. ..|||.|.... . . .|. ||....||   ....|..   | | ... . |..|   |  |
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetai

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 944-1215 3.7e-41 136.2 In-house 24-281 (305) alignment
Range on Protein: 944-1215
Range on HMM: 24-281/305.0
LDEQFNLIMKMkPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT-
|..|......  .  ..  |  ..|.|||  . .. . .|. ..  . .|   |||||...||.|...|||.| |  .|..|||....|   .||| || 
leaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

--DDQKEDEPIYWPTNVDEPLTLGALTITLWKRNTLispssqGKFlgqssqgTHTPLVIQNKEFdDDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVqkr
  ...|.    |||... |.  .| ....|  ..|         .       .   | | ...  |... .| ||.   |||   |  ..  |.  .   
lveggkdkCrqYWpesktekkefgefsvelksekta......sdy.......ieRklkisiede.dkesrtvlqyqltdWPdhGvpqfat.sllsli...

NEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
..  .. .|.   |..||   |   .|.|.|..   . . .|| ||... .|    ||...... . | .|. ||. 
krvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 930-1216 4.7e-41 135.7 In-house 9-278 (288) alignment
Range on Protein: 930-1216
Range on HMM: 9-278/288.0
VDRMTLPDEVGRVVLDEQFNLIMKMK-PRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWK
|.. .  .  .|  . |..| . ...  .. . ..  . ..|||  . .|..  || . ... ..|  |||||...|......|| || | |.|..|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MLWEHNSTTIVTLTDD---QKEDEPIYWPTNvDEPLTLGALTITLWKRNTLISPsSQGKFLGQssqgthtplviqnkefDDDDQLNVRQYHCSYWPDCCS
. .|....||| ||.    .|.    |||.. |.|   | .|.|| . ..| .   . |.| .                 . ..|.. ||.   |||   
lvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledf.vlrkllle................kkkteleitqyqylaWpdhgv

PLHTAfDLIYAVQKrnefLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
|  .| .|.  ...    .. .|.. .|||.||   |  ..||| || .| ... .|. .|.  ||.    .|..|.   . | .....| | 
Peska.pllellrq....vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 962-1215 6.5e-41 135.2 In-house 4-240 (250) alignment
Range on Protein: 962-1215
Range on HMM: 4-240/250.0
SKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED--EPIYWPTnvDE
.|  | |.|||..|.|... ||| .  . |     |||||||.||. .. .|.|| |  .|.||||.|..|..|.||| ||. . ..   . |||.  ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv..ek

PLTLGALTITLWKRNTlispssQGKFlgqssqgTHTPLVIQNKEfdDDDQLNVRQYHCSYWPDCCSPLHTA--FDLIYAVQkrnefleRSNKE-TVGPIT
. . | .|..| ....       . .       |.. |.. ...    |.  |||.|   ||| . | ..   ..|.  ||       .|...   .|. 
aekyGdvtvsllskee......fady.......tkrklklskak..kaderivrqlhfvvWPdkgvPevatavLellkkvq.......asqqqagnaPvi

VHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|.  .|  ..|.|.|.... . . .|. ||..| .|   ..||. ..|.| | ....... 
vqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk

subfamily_CG7180_pd Subfamily CG7180 941-1214 1.5e-39 130.4 In-house 16-287 (296) alignment
Range on Protein: 941-1214
Range on HMM: 16-287/296.0
RVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVT
||  . ...|. ...  |       . . |||| . .| .  || .. . |   . ||||.. ... ...|||||. |  ||...||........ ..| 
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LTDDQK--EDEPIYWPTNVdePLTLGALTITLWKRNTLISPSSQGKFLGQSsqgtHTPLVIQNKEFDDDDQLnVRQYHCSYWPD-CCSPLHTAfDLIYAV
||.     .  | ||| .       | . . . . ...    ..   | .        |  |.|. . .  . |....   |.     || |.  ||. .
Ltktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkk....ivalteqekqvkaetRi.vklfqlteWeledkvPlstn.alielr

QKRNEFLERS-NKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
.. . . |.  .... ||. |.   |.  .| ..|.    . ...|| ||... ||    .||.|. . |.| |..  |.
rrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_ptpA1_pd Subfamily ptpA1 675-875 2.2e-39 130.4 In-house 46-257 (418) alignment
Range on Protein: 675-875
Range on HMM: 46-257/418.0
ENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNrQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERY
 |  |||||||.  . .|| |. .     |||||||||||    | .|.||| |  |  ||||.|||..  .|||...  |  | ||||||| .   |..
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

NELEV--------TLELKEKFASYTLRTFLLKHRHKKHGKvpERRVYHFHYTDWPDHGVPPYTLPVL----SFIQRSSAANPTD--AGPIIVHCSAGVGR
.            ..|| |            . |    |.   | . ...|  |||| .| .| |.     |  .|     |.     ||||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfege..trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYIVIDTMLKQMQ
|||.     |.|...
tgtfctavimmkkld

subfamily_PTPRB_pd Subfamily PTPRB 921-1217 2.6e-39 130.0 In-house 7-285 (293) alignment
Range on Protein: 921-1217
Range on HMM: 7-285/293.0
VKSTELRQYVDRMTLPDEVGrvvLDEQFNLIMKM-KPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPS
.| ... ..|..|.  ....   . |... . .. | .  ..... . . |||  ...| . ||| .. . . .   ||||....||. ..|.|.|| | 
iklekfeehvkkmkadsdlr...fseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AETMEDFWKMLWEHNSTTIVTLTD---DQKEDEPIYWPTNvDEPLTLGALTITLWKRNtlispssqgkflgQSSQGTHTPLVIQNkefdDDDQLNVRQYH
 ||..|||.|.||..|..|| ||.     |.    |||.. .|| . | ...|| . .             . .. .   | |..    .... .|||||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaee.............eledwvirelkiek....ekeerkvrqyh

CSYWPDCCSPLHTAfDLIYAVQKRNEFLERsnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
   |||   | .|.  |.  |.. .| .|.  ... .||.||  .|   .||| || .| |.. .|. |||. .|     .| .|. . ..| .. ....
ftsWpdhgvPektk.tlldfvrtvreaiek..taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvl

SCH
.  
dll

0044763 (Phosphotyrosine protein) phosphatases II 688-917 1.4e-38 127.6 In-house 2-174 (178) alignment
Range on Protein: 688-917
Range on HMM: 2-174/178.0
YDSSRVSLQPLPGIPNSDYINANYIDGFnrqkAYIATQGAlkttfDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTperynelevtlelkekf
.| .||.|..|.|.. ||||||..|...     |......      |...|..|..  .||..|.  |.|. |||.||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

asytlrtfllkhrhkkhgkvperrvYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQmqaeeKVNVFGFLK
                         ...... .||||||. .  .| |..   .| ... ||..|||||||||.|| .... |.|.     .....  ..
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

RIRTQRNyLVQTEEQYVFIHDVLLEWLRAG
..| .|.  |....|. ..... |..|  .
lvrerRp.ivpnpgqlrqLyefelrllkes

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 655-915 4.7e-38 125.4 In-house 16-270 (281) alignment
Range on Protein: 655-915
Range on HMM: 16-270/281.0
EYEEIQHV-PTSFPATFSSDVENKlKNRYTNIVSYDSSRVSLQP-LPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITK
|. ..    |. . ..|   |.|| ||||.||   | ||| |.  .|    .||| ||||     .. || |||  | |  ||||..|....  |||. .
efsnlpgdppsdlctvfnqpvnnk.knrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

LEERGRRKCDRYWPAKGT-PERYNELEVTLElkekfaSYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSfIQRSSAANPTdagPII
. |  | ||  |.| .     ....| |. |        |.   |.  | .   .   | . |. . .|||  ||  .  .|  | |   |  |   | .
fletnrekcaeyfprnahcclqfdklsvsye......dstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk.ilrkirarst...ppv

VHCSAGVGRTGTYIVIDTMLKQMQAEEKV-NVFGFLKRIR-TQRNYLVQTEEQYVFIHDVLLEWLR
.||||||||.|| . ..  |. ...   . ..   . ..| | |   ||| .||..|  |||..  
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 641-920 4e-37 122.4 In-house 18-296 (310) alignment
Range on Protein: 641-920
Range on HMM: 18-296/310.0
VIACHANSDGGFAAEYEEIQHVPTSfPATFSSDVENKLKNRYTNIVSYDSSRVSLQpLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVW
.||       |.. .|  ..    |   |. .  ..  ||||...|  |.||| |. .      ||| |||.     ....| .|| |. |  ||||...
iiateklgieglvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmif

EQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTL--ELKEKFASYTLR-TFLLKH--RHKKHGKVPERRVYHFHYTDWPDHGVPPYTLpvLSF
....  |... |  | || ||  |||. |  | |  . ||   |  |.|    |  ||.       ..  .. | ||   .. .||| |||       . 
qeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htv

IQRSSAAnpTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTV
 ||  |      || .||||||..|... . ..  .....  .||..      .. .|   .||| ||..|. | . . |. . |
pqrllaq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetev

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 671-915 2.4e-36 120.2 In-house 38-272 (288) alignment
Range on Protein: 671-915
Range on HMM: 38-272/288.0
SSDVENKLKNRYTNIVSYDSSRVSLQplpgiP-NSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPA-K
.| ..|  ..||.|.   | .|| |.          ||.|| .   . ..  | .|  |..| . .|... |.    |||...| |.|..| . |.|  .
dsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GTPERYNELevTLELKEKFAS--YTLRTFLLKHRHKKHGKVperRVYHFHYTDWPDHGVPPYTLPVLSFIQRSsaanPTDAGPIIVHCSAGVGRTGTYIV
|   |.. |      |.| |    ...  ||.  .. . ||    | . |. .|.|.|||   |. | ....      .   ||.||.||||||||| |.
Gekarigrl..ctvvkkkradidklvkvsllriskegeekv...ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlil

IDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
|  .|.... .. . .  .|.. | .|   .||| ||...| ..|| | 
ilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

PTPc_DSPc_SM00012 812-912 3.3e-36 119.0 In-house 2-105 (105) alignment
Range on Protein: 812-912
Range on HMM: 2-105/105.0
VYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDA--GPIIVHCSAGVGRTGTYIVIDTMLKQMQAE-EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
|.|.|||.||||||| .. ..|....     .   .  .|..||||||||||||....|..|.|...| ..|..| ..|..|.||. .|||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLLE
.|||
alle

0051082 (Phosphotyrosine protein) phosphatases II 703-911 7e-36 118.4 In-house 2-150 (151) alignment
Range on Protein: 703-911
Range on HMM: 2-150/151.0
NSDYINANYIDGFnrqkaYIATQGALKttfdDFWRLVWEQKSVVIVMITKLEERGrrKCDRYWPAKGtperynelevtlelkekfasytlrtfllkhrhk
 |||||..|..|.     .....| |     ||..|..|..  .||.....||||  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

khgkvpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAanpTDAGPIIVHCSAGVGRTGTYIVIDTMLkQMqaeekVNVFGFLKRIRTQRNYLVQTEEQ
       ..|.|....||||.|.| ..  ||.|..   .   .. ||..||||||.||||| .... || ..     |...  |. .| .| ..||...|
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

YVFIHDVLL
..|.. .||
flfqlfall

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 667-829 1.7e-35 117.4 In-house 22-183 (297) alignment
Range on Protein: 667-829
Range on HMM: 22-183/297.0
PATFSSDVENKL--KNRYTNIVSYDSSRVSLQplPGIPNSDYINANYIDGFNRQK--AYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCD
. .|||   |    ||||..|...|..|| |.   .|...|||||.|.   . ..   || .|| |..| ||||.||.||   ||||..||.| || || 
gesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

RYWPAKgTPERYNELEVTLELKEKFA----SYTLRTFLLKHRhkkhgkVPERRVYHFHYTDWPDHGVPPYT
 |||     || .  .| .|   ...       |  . | .|        .| | |  .  |||||||   
pywpsv.vqerlkagdvvveflsstsdefdrviltelqliyr......sesrvvrhvqflswpdhGvpsdl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 962-1214 2.4e-35 117.0 In-house 44-276 (315) alignment
Range on Protein: 962-1214
Range on HMM: 44-276/315.0
SKARQSKHKNRDMDLIPVERSRV--PISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPtnvD
.|  . |.||| .. |. ..|||  |.  .     |.||.|..|| ... || .| | .....|||....|.. ..|| ||.  ....     |||   |
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...d

EPLTLGALTITLWKRNTLISPSSQgKFlgqssqgthtplviqNKEFDdDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQKrnefLERSNKETVGPITVH
. .. | .|.|. . .     . .  .                  |. |.  .| |.| . |||   | .|   |.  ...      . ....||.| ||
kkviyGkitvtrkseevnteytvr.tl...............svvfg.dnirevvqlhytswpdmgvpkyti.plmnlirt....vkqhhtnsvgaivvh

DRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 ..|  ..|||..|... ...  |.|.|.|. ..   ..| ... . | | ....|| 
csaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_PTPN12_pd Subfamily PTPN12 961-1223 5.2e-34 112.4 In-house 34-283 (290) alignment
Range on Protein: 961-1223
Range on HMM: 34-283/290.0
FSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNV
 ... . ..|||  |..| . ||| .|   ...  .||||.|..|   . ||| .| | ..|..|||.|.||.| . .| .    . .|     ||| ..
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

DEPLTLGALTITLWKRNTLispsSQGkFLGQSsqgthtpLVIQNKefddDDQLNVRQYHCSYWPDCCSPLHT--AFDLIYAVQKRNEflersnkETVGPI
.|.|. |....|| . ...    ... || ..       | ....    ... .|.|.|   |||   |  .   ..|| .|....|       .   |.
eeelefgefevtleeekav....ddd.flirt.......Lkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......sedaPl

TVHDRSGGCQAGTFCALSTLHQEMIHEEA---VDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHSAELQI
 ||  .|  ..|| .|.   .. . .|     .|... |     .|. |. ..| | ...||. .  ..||.|
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 963-1214 6.7e-34 112.1 In-house 40-274 (315) alignment
Range on Protein: 963-1214
Range on HMM: 40-274/315.0
KARQSKHKNRDMDLIPVERSRVPI---SGVPGVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVD
. ..  .|||  . .|....|| .      |  | |||||.....  .. || .| |   ...|||.|..... |||| .|. |..|      ||| .  
retinfkknryknilPldsarvkleviddsPdsd.yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

EPLTLGALTITLwkrntlISPSSqgkflgqSSQGTHTPLVIQNKefddDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQKrnefLERSNKETVGPITVH
.   .|.. ..|      .| ..        ..|..  ||...     ... .| |..   |||  .. .|.  |.  ...    .  .|..   .. ||
dsvefGsikvel......lslea.......dtdgvarklvtrks....eesrtvtqfqftewPdkGvdkqts.sllklike....vkadngkkefsllvh

DRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
  .|  ..| ....    ... ....||....||   |||| |. ..|.| ... |..
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl

subfamily_PTPN6_pd Subfamily PTPN6 937-1216 8.3e-34 112.0 In-house 21-296 (306) alignment
Range on Protein: 937-1216
Range on HMM: 21-296/306.0
DEVGRVVLDEQFNLIMKMKPRDYeFSK----ARQSKHKNRDMDLIPVERSRVPISgVPGVDG--YINASFLQGYR--RQNEYIVTQYPSAETMEDFWKML
.....  . |.|. . ... ... .|.      . |.|||    .|.. .|| ..  |.| |  ||||.....     ...|| ||    .|..|||.|.
eslekagfeeefeelqqeeakkl.lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

WEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLtLGALTITLWKRNtlispssqgkflgQSSQGTHTPLVIQNKEFDDdDQLNVRQYHCSYWPDCCSPL
|. ||. || .| .     |    |||.. ...   | ...|  . .             . .. .   |....|.... .. .|.|||   |||   | 
wqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.............sladYilRelsvskkkkkk.eerevfqyhfksWPdhgvpk

HTA--FDLIYAVQKRNEFLERSnkeTVGPITVHDRSGGCQAGTFCALSTLHQEMIH---EEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
..    |..  |....| ||..   . ||| ||  .|    |||  . .| . . .   .  .||.|.||.  . |  |.   . | ...||..  
dpgavLdfledvnrkqeeleea...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 957-1214 3.2e-33 109.9 In-house 36-280 (290) alignment
Range on Protein: 957-1214
Range on HMM: 36-280/290.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV----DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PI
   .   . ..|..||  .... .  |...  ..|     . ||||....||. ...||.|| |  .|. ||||..|....| || ||. ..|..     
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

YWPTNvDEPLtLGALTITLwkrntlispssqgkfL--GQSSQGTHTPLVIQNKEFDdDDQLNVRQYHCSYWPDCCspLHTAFDLIYAVQKrnEFLERSNK
|||.. |    .|  .|.|               |   . .. ... | ..||. . ... .| ||. . |..     .|.   |  | .  |  .   |
YWpds.dtka.ygefsikl...............lneetlneyierklevknknsa.gakqsvtqyqitnwdstg..kvtnpqtillvie..emyktqrk

ETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
.. ..| ||   .  ....|||. |  . .  |  .|... .|    ..|..... . | ..|. . 
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 943-1215 3.9e-33 109.7 In-house 21-276 (287) alignment
Range on Protein: 943-1215
Range on HMM: 21-276/287.0
VLDEQFNLIMK--MKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPgvDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT
   .|| .. .   .. .   . | | |.|||  .... .  ||.. |    . ||||.|..||. ....|... | ..|. .|||.....| |.|| |.
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgeh..pdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc

DDQKEDEPI---YWPTNVDepLTLGALTITLWKRNtlIspssqgkflgqSSQGTHTPLVIQNKEfDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQK
... .|| .   |||..    ..||  .|.| ...  .           ... .   | ..||.  ..|...|.||.   |..     . .   .  ...
qekendeevcyqyWpeeks..vvlGeyniellnee..v...........nagyierklevknkn.kagdkqqvkqyqitnWdstgkvtepq.tillviee

RnefLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
.        |.. ..| ||   .  ....|||  |  ..   | ..|... .|    ..|. .   | | ....... 
m...yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle

0041856 (Phosphotyrosine protein) phosphatases II 967-1213 4.2e-33 109.9 In-house 1-167 (182) alignment
Range on Protein: 967-1213
Range on HMM: 1-167/182.0
SKHKNRDMDLIPVERSRvpisgvpgVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTddqkedEPIYWPtnvdepltlgalti
...||| .| .|...||        .  ||||... |.......|.|| |  .|..||..||.|.. ||||.||      |. |||              
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp..............

tlwkrntlispssqgkflgqssqgthtplviqnkefdDDDQLNVRQYHCSYWPDCCSPLhtafdliyaVQKRNEFLERSNKeTVGPITVHDRSGGCQAGT
                                     .. . .. ||..  ||| . |          ... ..|.|. ..   ||. || . |   .||
.....................................ellerlgiqylylpwpDhgvpd.........ldelldfieevle.eggpvlVHCsaGvgRtgt

FCALStlhqeMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
..|.      ....  |.....|||.  .||. ... . |..|  ||
lvaay.....lmkklgvsleeavklvrsrRpgmvitpnqyfflqlal

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 946-1216 1.2e-32 108.3 In-house 27-287 (325) alignment
Range on Protein: 946-1216
Range on HMM: 27-287/325.0
EQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISG--VPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKML--WEHNSTTIVTLTD
 .|.|.    .  .. .   . | |||  .......||| .      .   |||||.|. ..... .. .| | ..|..|.|...  |.     ..   |
hefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneld

DQKEDEPIYWPTNVDEPLTLGALTITLWKRNTLiSpssqgkflgqssQgtHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIY---AVQKR
 .|.   .||| .. .  |.|.| . |   ... |               .   |.. |. .. . . |.|..   |.|   . . |  ||     |.. 
lgkdrcavywpkemgksktfGglevklrtieei.s............d..yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpa.tlisilqlvkav

NEFLeRSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
.| . ..| .. .|| ||  .|  ..|.| .| .. ...|.|  |||.. ||   ..||... . . |  ...||   
serv.tantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea

subfamily_CG42327_pd Subfamily CG42327 656-836 5.6e-32 105.7 In-house 8-187 (319) alignment
Range on Protein: 656-836
Range on HMM: 8-187/319.0
YEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQ-KAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLE
.|| ...|     .    |  | |.|. |.|    .|| ||  .  ... |..|.|. |..     |||.| .|. .  ||||.||||.| ||| .|.| 
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERGRRKCDRYWPAKGTP---ERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGkvpeRRVYHFHYtDWPDHGVPPYTLPVLSFI
| | ..| .|.|.| |    . | .. |||  .|    | . |.|||. .|.      | . |. | .|.. .||    .... .
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkees....relthywy.kwleaevPaeeaaliaml

subfamily_PTPN9_pd Subfamily PTPN9 941-1213 7.4e-32 105.6 In-house 15-286 (297) alignment
Range on Protein: 941-1213
Range on HMM: 15-286/297.0
RVVLDEQFNLIMKMKPR-DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIV
.  | ...  | ....   .. || |   .|||  |.. ....|| .. |.. .   ||||.|..||.... .| || |  .|..|||.|.||..  .||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

TLTD---DQKEDEPIYWPTNVDEPLTLGALTITLwkrntlISPSSQGKFlgqssqgTHTPLVIQNKEfdDDDQLNVRQYHCSYWPDCCSPLHT--AFDLI
  |     ..     |||.. ..    | |...       ..  .. ..       ... |.|.| .  .... .|  .    |||   |  .   .|..
mttrvvergrlkcgqyWpleeessaefgdlsvsn......veveeeedy.......kvrvleiknvk..teesrkvthfqflsWPdyGvPssaaslldvl

YAVQKRNE-----FLERSNKETV-GPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 .|...       . .... ..   || ||  .|  ..|||..|    ... ... ||. .||||  ..|   |   | |.. ..|.
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 671-924 1.2e-31 104.8 In-house 30-279 (285) alignment
Range on Protein: 671-924
Range on HMM: 30-279/285.0
SSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYIDGF-NRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK-
..   |   |||...   . .|| |.      . ||| |...    . | .||.||| |  |. |||......|   ..|.  | | |  ||  |.| | 
tayeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

GTPERYNELEVTL-ELKEKFASYTLRTFLLKHRHKKHGKVPeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAgPIIVHCSAGVGRTGTYIVI
|   .. . |.|| | ||.  . |.   |     .     |   . | .   |||.  |  . |.. . .     || .  || |||||||||| |.. |
gevvkfgkyeitlteckeeaiagtilnaltvintedassep.lymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgi

DTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLrAGNTVVKST
|    ..  . .....  .. .|. |   ||.  |..|.. ||.|..  |. ||. |
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf.igegvvert

subfamily_PTPN23_pd Subfamily PTPN23 942-1212 1.9e-31 103.9 In-house 15-275 (288) alignment
Range on Protein: 942-1212
Range on HMM: 15-275/288.0
VVLDEQFNLIMKM---KPRDYEFSKARQSKHKNRDMDLIPVERSRVPISgvPGVDGYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIV
 .||..|... .    . |.   . |.   .|||  |..| ...|| .    . | ||||||...   .  ..|.|| | ..|. |||.|..|  | .||
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

TLTDDQKEDEP---IYWPTNVDEPLTLGALTITLWKRNtlispssqgkflgqsSQGTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPL--HTAFDLI
 |.. .. ..|    |||.. .|. . |.|..|| . .               . .||   |.. .  | |   .|.  .   ||.   |   .| ....
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr...............etethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

YAVQKRNEFLERSNKEtvgPITVHDRSGGCQAGTFCALSTLHQEMIHEE-AVDIYKTVKLYAAKRPNLITSREDYYYLFKA
 .|..  |  .|  |    |. ||  .|   .|.|. . .  .|. ...  .|| . |.   ..| . .  .| .  ...|
devesayeavqrkskt...PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 964-1217 4.5e-31 103.1 In-house 48-284 (297) alignment
Range on Protein: 964-1217
Range on HMM: 48-284/297.0
ARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRqnEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEP--IYWPTNVDEPl
 .   .|.|  . .|...||| .  |       |.||||..|..   ..| || |  .|..|||.|..... .||| |.||...|.    ||. .   . 
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt.

tLGALTITLwkrntlISPSsqgKFLGqssqGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSPL-HTAFDLIYAVQkrnEFLERSNKETVGPITVHDR
 .| ....|       | |   .  |    . .  |....   .   .  |.||.  .|||   .  ..|  |.  ..   |  .  .... ||. ||  
.fGdvsvvl......lsvs...ereG....fikrelevtkg..kakarrvvkqyqfveWPdkaverkdsassllklis...evrkdfsqnaegPllvhcl

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCH
.|  ..| ....     |. .|..|||...||    .||.|.  .|.| ....|.    
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 953-1213 2.9e-30 100.1 In-house 19-262 (283) alignment
Range on Protein: 953-1213
Range on HMM: 19-262/283.0
KMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGvdGYINASFLQ---GYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD---DQKED
 . ..| . . |.. |.|||  ...|... || .   .    ||||.|.     |.....||..| |  .|. |||||..... |.|| ||    |... 
svpdldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

EPIYWPTNVDEplTLGALTITLWKRNTLISPSSQGKFLGQSsqgthtplviqnkeFDDDDQLNVRQYHCSYWpdccspL-HTAFDLIYAVQKRNEFLERS
   ||| .  |    | .|.|| |  |  | . .   | ..                  ..| .  |    |      |       | .. | |      
CsqyWPkrGse..dyGeftvtlrkettsnsfiikelllrvn..............ssakstlllahyqvidW......leygeqaiinslvkfnkvislq

NKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
...  ||| ||  .|. ....|.|.|.  ...  |  ||....||    .|. .. ... |  . .. 
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 966-1220 7.4e-30 98.7 In-house 37-280 (287) alignment
Range on Protein: 966-1220
Range on HMM: 37-280/287.0
QSKHKNRDMDLIPVERSRVPISGVP--GVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEP---IYWPTNvDEPLT
 . .|||  |..|.. .|| .|  .  |.| |||| .. .|......|..| | | |. |||....|..|....|.| . .|       ||| . . |. 
aavkknryadvlPiddtrvllsaegelGsd.yinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

LGALTITLWKRNTlISPSsQgkflgqssqGTHTPLVIQnkeFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQKRNEFL--ERSNkETVGPITVHDR
.|  ...| ...   .|            |. .  .|.    .  .   |.|..   |||   .  ||  ||  | . ....  .|.  . |||. ||| 
vGGysvvlldydi.kePe.y.........gvralrlid...letrearvvkqldllswPdkvla.Ptavglirfvldvkqhielarda.sevGPlvvhdd

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHSAE
 |  ..|.. |. .| . .     ||. ..|     .|  |. .   . .|..|| . . ..
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 969-1213 1e-29 98.1 In-house 45-272 (515) alignment
Range on Protein: 969-1213
Range on HMM: 45-272/515.0
HKNRDMDLIPVERSRVPI---SGVPGVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEP---IYWPTNVDEPLTLG
.|||  . .| ...|| .      |  | |.|||.....  .. || .| |   ...|||......| |||. .|. ...|      |||    . . .|
kknryknilPydsvrvklevindnPhsd.yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

ALTITlwkrntLISPSSQGKflgqssqGTHTPL-VIQNkefddDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQkrnEFLERSNKETvGPITVHDRSGG
 . .       |.| .. .        |.   | |...     ||   | |.|   |||  .| ||   |.  ..   |     .. |  |. .|  .| 
sikve......lvsleactg.......gikrkltvlkg.....ddsrtvtqfhfteWPdkGvpkhts.sllklik...evkadhgqyt.hpliihcsaGv

CQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ..| ....     ..   ..||....|.   .||| |.  .|.| ... |.
GrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 676-917 2.4e-29 97.1 In-house 43-279 (312) alignment
Range on Protein: 676-917
Range on HMM: 43-279/312.0
NKLKNRYTNIVSYDSSRVSLQplpGIPNsDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGT-----
 |  ||| ||  .|  | .|    |  |  || ||..    . . ...|||.|. |   ||.|.    |. |.... . | |  || .|     .     
fkdlnrypniqcwdrgrftla...gden.fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

-PERYNELEVTLELKEKFASyTLRTFLLKHRHKKHGKvpERRVYHFHYTDWPDHGVPPYTlpvlSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDT
    | |    .|.  |     .   .||   |  |.  | .. |. .. |||||.|          .|  .|   |  |.| ||||||||||| ..|..
dhrvyteycteieiggkskd.kithrvlkvvvkatgq..esklnhyqwaswpdhgmpdsc....dtalrllsavkkdkkpviahcsagvgrtgtlalies

MLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
|.  ..   | ||   .  .| .|   |..  |||.   ..||.| . 
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 946-1215 3.8e-29 96.6 In-house 10-266 (274) alignment
Range on Protein: 946-1215
Range on HMM: 10-266/274.0
EQFNLIMKMKPRDYEFSkarQSKHKNRDMDLIPVERSRVPISGVPGVD---GYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD
| ..| . ....... .    |..|||  ...| |.||| ..   . |    |||| ...||... . |. || | ..|..|||.|....... || ||.
eflelPlnfdqeeldvf...gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

DQKEDE---PIYWPTNVDEPLTLGALTITlwkrntlispsSQGKFLGQSSQGTHTPLVIQNKEF--DdddqlnVRQYHCSYWPDCCSPLHtAFDLIYAVQ
 . ..|     |.|.. |  ..     .             . .   .  . . . ||... |   .      |  |  . |||  || . |  |.  |.
lkeaneqkCavyfPdaedyeiserygdve...........ikvekiverndysvrklvlkylerers......vkhywytdWPdhksPdd.antlldlvl

KRNEFlERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
. .|  ...... ..|. ||  .|  ..| | | |   ... .|. ||. |.|     .|  .. ..| | ....||  
evees.reeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 707-905 4.6e-29 96.1 In-house 78-272 (301) alignment
Range on Protein: 707-905
Range on HMM: 78-272/301.0
INANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTperyNELEVT-LELKEKFASYTLRTFLLKHR---HK
| ||.|.   . . .||||| || | .||| ..   .   |||...  |.  .||. | | | .    ..|..   ..| |   . |.  . | .   . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....ekldigrfkikiknkelilnkkiskrtleved

KHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANptdaGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQ
  ||.. | | |. |..|.|.|||     .  ...    ..     ||.||||||.||. ..|  . . ....|. ....   ||..| .|   |||..|
stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YVF
  .
lyw

subfamily_egg_pd Subfamily egg 667-933 5.8e-29 95.7 In-house 31-287 (307) alignment
Range on Protein: 667-933
Range on HMM: 31-287/307.0
PATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrRKCDRYWP
. | . . .|. | |   .   ||||| |.   |    |.| ||...|      .| .|  || | |||||.|....   |||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

aKGTPERYNELEVTLELkEKFASYTLRT--FLLKHRHKKHGKVPERRVYHFHyTDWPDHGVPPYTLPVLSFIQRSSAanptdagPIIVHCSAGVGRTGTY
 |   .    .  .|.. | .  .      | . . .   |.  || . |.   |.   .   . | ||  ... |        |..|..  || ...| 
.kaesdslvtvpGslri.enlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrklrnlsk.......pvvvqdilGvskaatl

IVIDTMLKQMQ--AEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKstELRQYVDRM
. |.. | ..      |  |    . .| .|.. |..  .|.|.. ..| ..|     .|  ||    .| 
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak..eldvdyerw

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 923-1213 6.7e-29 95.6 In-house 4-275 (439) alignment
Range on Protein: 923-1213
Range on HMM: 4-275/439.0
STELRQYVDRMtlpDEVGRVVLDEQFNLIMKMKPR---DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPS
 .|....|...   |   . ...| |. |  ..|    .  .     .. |||  |. . . .|| .  .|||    |||| ...||  .. || ||.|.
rdefqehvekl...dknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

AETMEDFWKMLWEHNSTTIVTLTDD---QKedepiYWPTNVDepLTLGALTITLwKRNTLIsPssqgKFlgqSSQGthtpLVIQNKEFDDDDQLNVRQYH
 || .|||....|....|||.||.     |     |||.. .     | ...    ||  . |    ..     .|    . . |.    . .  | |.|
kettddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrv.drniel.p....ny...virg....fkvfnerdttekertvlqfh

CSYWPDCCSPLHTAF--DLIYAVQKRNeflersNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
   |||   | ....  |.. |..  |      .|| .||. ||  .|  ..||  ||    ...  |. |||   ||.   .| ... .  .| ....|
yiawpdknvpaqashvldflrainsan......dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna

L
.
v

subfamily_PTPN13_pd Subfamily PTPN13 945-1213 3e-28 93.9 In-house 14-265 (273) alignment
Range on Protein: 945-1213
Range on HMM: 14-265/273.0
DEQFNLIMKMKPRDY-EFSKARQSKHKNRDMDLIPVERSRVPISGVPGvdgYINASFLQGYRRQN--EYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD
.|.|. . ..|| |  | .| .. |.|||  ...|....||....  |   |||||...    ..  |||..| |  ||..|||.|.|| ... |. .| 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

DQKEDE---PIYWPTNVDEPLTLGA-LTITLWKRNTLispssqGKFLGQSsqgthtplvIQNKEFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQK
.. ...     ||| . ...|..   |...| | . |        |  ..         .. |. .  .  .| . .   |||   |  .| .|.  |..
ekekgkvkchrywPesknkklkvsnrlevellkvqkl......dgfvvra.........lavkdsesgesrevahlnfvkwPdhgvP.ssaaellqfvae

RNEFlersnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ...     ..  ||| ||  .|  ..||. .. .. . . ... .|. ..|.    .|  .. ... | . .||.
vrrl.....qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 809-938 4.3e-28 92.8 In-house 88-218 (440) alignment
Range on Protein: 809-938
Range on HMM: 88-218/440.0
ERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA-ANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIH
 | . ..||  |||.||| .. ||| .||  .   . .  ||..||||||.||||  |..|..|.. .  .....| |.. .| .|  .||| |||.|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DVLLEWLRAGNTVVKSTELRQYVDRMTLPDE
...|| | .|.|..   .. . |...  |. 
eavlegllcgdtliledditerveqiqwpnp

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 960-1216 5.5e-28 92.9 In-house 34-275 (281) alignment
Range on Protein: 960-1216
Range on HMM: 34-275/281.0
EFSKARQSKHKNRDMDLIPVERSRVPIS--GVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTN
. ||| . ..||| ....  . .|| ..         ||||.|..||. ..|||.|| |  .....||.|.||.. ..|| .| . ...      ||| .
taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

VdEpltlgaltitlwkrnTLISPSSQGKFLGQSSQGTHTPLVIQNkEFDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIyavQKRNEFLERSNKETVGPIT
  .               .|.    . |.. .... |.   ...  | .. .. .|.| .   |||   |  |. .|.   . |.| |. ..|.|  |. 
n.s...............elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattk.ell...efrkevlkltekktkaplv

VHDRSGGCQAGTFCALSTLHQEMIHE-EAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
.|  .|  ..||. || .| ... .| | .|.  .|.    .|  .. .   | ...||.   
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

0048076 (Phosphotyrosine protein) phosphatases II 764-913 2e-27 91.0 In-house 2-142 (145) alignment
Range on Protein: 764-913
Range on HMM: 2-142/145.0
YWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKhrhKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDaGPIIVHCSAGVGRTGT
|||.. .|  |     | .  | .... ..| |         . .|| .....|..|||||||. .  .|.|..   .| . . ||..||||||||||||
ywpseilpglylgslptaldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

YIVIDTMLKqmqaeEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
..... ||.     ..|...  |...|.|| . |....|. |.....||.
lvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel

0036282 (Phosphotyrosine protein) phosphatases II 994-1210 2.5e-27 91.1 In-house 3-163 (174) alignment
Range on Protein: 994-1210
Range on HMM: 3-163/174.0
GYINASFLQGYRRQNEYIVTQYPSAetmedFWKMLWEHNSTTIVTLTDDQKED---EPIYWPTnvdepltlgaltitlwkrntlispssqgkflgqssqg
 |||||.| .... ...|..|.| |     ||.||.|...||.|.|.. .  .    . |||.                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

thtplviqnkeFDDDDQLNVRQYHCSYWPDCCSPLHTAfdLIYAVQKRNEFLERsnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIhEEAVDIYKTVK
           . .|   .. ||..  ||| . |  .   |. .|.  .|.|..      ||. || . |   .||..|.  ... .. | .||....|.
...........lredlerlgiqylylpwpDhgvpdlsi..llefvkfveealse...dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvr

LYAAKRPNLITSREDYYYLF
    .||. ... . |..| 
elRlqrpgmvqtpsQyrfly

0043147 (Phosphotyrosine protein) phosphatases II 993-1210 1.2e-26 88.9 In-house 5-154 (172) alignment
Range on Protein: 993-1210
Range on HMM: 5-154/172.0
DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDqkedepiywptnvdepltlgaltitlwkrntlispssqgkflgqssqgth
. |||||.| .|.  ...|.||.|  .|..|||.||.|.. |.||.||.                                                   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

tplviqnKEFDDDDQLNVRQYHCSYWPDCCSPlhTAFDLIYAVQKRNEFLERSNKetvGPITVHDRSGGCQAGTFCALSTLHqemiheEAVDIYKTVKLY
           .. . .. ||.. .||| . |  ..  |. ...  .|.| .|..   ||. || . |   .||..|.  ..      . ......|.|.
.......lydpellerlgiqylylpwpDhgvp..llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

AAKRPNLITSREDYYYLF
 .|||. ... . |..| 
rekRpgavqnpsqyrfly

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 957-1215 8.9e-26 85.5 In-house 10-262 (270) alignment
Range on Protein: 957-1215
Range on HMM: 10-262/270.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIY
 . .. .| . |. || .|..|  ..|| .. .    .  |||| ...|.   ...|| .. | . |...||.|.||...|.|| .|   .. ..    |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPTNVDEPLTLGALTITlwkrnTLISPSSQGKFLgqssqgTHTPLVIQnkefDDDDQLNVRQYHCSYWPDCCSPLHTA-----FDLIYAVQKRNEFLERS
||....| ..| . .|.     .| . ... ..         | | ..    .. .. ..  ..   |||   | ..       .|.. ...  .. .. 
Wpaepkekvkledgkik.....vlalseekeegy......iltrlrle....ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekel

NKETvgPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
.|..  |. ||.  |   .||. || .  . . ... ||. . ..    .|..|.   | | .|.||.. 
dkae..PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

0048179 (Phosphotyrosine protein) phosphatases II 798-908 1.1e-25 85.4 In-house 35-139 (144) alignment
Range on Protein: 798-908
Range on HMM: 35-139/144.0
KHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDaGPIIVHCSAGVGRTGTYIVIDTMLkqmqaEEKVNVFGFLKRIRTQRNYLV
  ... .   .|| ........|||||||...  .|.|..   .| . . ||..||||||||||||..... |.     .......  |...|..| . |
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QTEEQYVFIHD
....|. |...
pnpgqlrfLle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 670-777 3.2e-25 83.6 In-house 41-162 (350) alignment
Range on Protein: 670-777
Range on HMM: 41-162/350.0
FSSDVENKLKNRYTNIVSYDSSRVSLQ----PLP----GIPNSDYINANYIDGF------NRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEE
.|. ||   ||||.||. |. ||| |.    .       .  .|||||||.         | .  |||||. |. |.|||.... . |  ||...|.. |
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

RGRRKCDRYWPAKGTPERYNEL
 ...||.|||.  .  .    |
lnlekcyrYWqegsydditvkl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 944-1214 4.9e-25 82.8 In-house 17-290 (301) alignment
Range on Protein: 944-1214
Range on HMM: 17-290/301.0
LDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV----DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
..||.. . .....  . .   . |. ||  .  ...  |. ..  | .      |||||...||......|..| |  .|. |||...|..  ..||..
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

TDDQ---KEDEPIYWPTNVDEPLTLGALTITLWKRNTL---ISPSSQGKFLGQSSQGTHTPLVIQNKEFdddDQLNVRQYHCSYWPDCCSplhtAFDLIY
|. .   |.    |||.   |  . | .|.|| . ...   .  . . |    |..|     .  ....   .  .| |..   ||.         .   
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGv....vreprt

AVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 .|  .. . | .|   ||. ||   .  ..|..|..|        |  ||... .|    ..|  .|  | |  ......
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

0049260 (Phosphotyrosine protein) phosphatases II 1000-1210 1.3e-24 82.0 In-house 1-143 (152) alignment
Range on Protein: 1000-1210
Range on HMM: 1-143/152.0
FLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---KEDEPIYWptnvdepltlgaltitlwkrntlispssqgkflgqssqgthtplv
|..||....|.| ||.|  .|..|||.||.|.. ||||.||...   |. .. |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

iqnkefddddqlnvrQYHCSYWPDCCSPLHTAFDLIYAVQKRNEflersNKETVGPITVHDRSGGCQAGTFCALSTLHqemiheEAVDIYKTVKLYAAKR
               ||.. .||| . | .. . |.     .       ...  ||. || . |   .||..|.  ..        |.....|.|. .||
...............qylhlpwpDhgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekR

PNLITSREDYYYLF
|. ... . ...|.
pgavpnpgqlrfly

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 967-1212 1.5e-24 81.5 In-house 3-234 (237) alignment
Range on Protein: 967-1212
Range on HMM: 3-234/237.0
SKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD---DQKEDEPIYWPtNVDEPLTLG
.| |||  ...  . ||| . |  .   ||||..|.|.    ..|| .| |   . .|||.|.|. . . || ||     ...    ||| . |.| . |
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaayg

ALTITLWKRNTLISPSSQgKFLgQSSQGTHTplviqnkefdddDQLNVRQYHCSYWPDCCSPLHTAFDLIYavqkRNEFLERSNK-ETVGPITVHDRSGG
 ||..| |.. .   . .  .|  | ..|              .   . ||. . |||   | .||  | .    | . ..||..    ||  .|  .| 
vltvslkkkeefsdytvr.sll.lskrltlk............evrlihqyqftswpdrgvpqqtaallrf....rkniinrsphvsesgpwiihcsagv

CQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
 ..| |  . .. ..   .. ||||. |.     || .| ....| .....
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 944-1225 1.6e-24 81.4 In-house 8-265 (267) alignment
Range on Protein: 944-1225
Range on HMM: 8-265/267.0
LDEQFNLIMKMKPRDYE--FSKARQSKHKNRDMDLIPVERSRVPISGVPgvDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD
....|.|| |. .       | | . . .||  | .| . .||...     . |||||...||...| .|||| |   |. ||.... ... ..|| || 
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke..eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

DQKEDEPIYWPTNVDEPLTLGALTITlwkrntlispSSQGKflgqssQGTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCsPLHTAFDLIYAVQKRNEf
  ... . .|| .. .      ||.            |  |      .     ..  . .| ..   ||  |.   |       .  .  ....  .|. 
vftdnirlfwPPkmgqakkyqdltve..........hslek......eendyqiitlelkfknesahnvtlyyykkwnint.nnkpylkplfgilaknq.

LERSNKetvgPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALqsCHSAELQIRS
||  |.    |. |.   |  ..|||  . .  . . .|. .||.. ..    .|. |. ..| | |. . |  .. || ... 
lengnr....PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell..aeyaegrlke

0051429 (Phosphotyrosine protein) phosphatases II 992-1215 2.7e-24 81.7 In-house 3-223 (272) alignment
Range on Protein: 992-1215
Range on HMM: 3-223/272.0
VDGYINASFLQGYRR---QNEYIVTQYPSAETMEDFWKMlWEHNSTTIVTLTDDQ---KEDEPIYWP----------TNVDEPLTLGALTITLWKRNTLI
..|||||... || |    . .. ...|.  | .|||.. .|.. .|||.|...    ... . |||           ..... ..|||..||..  .| 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

SpssqgkflgqssqgTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTAFDLIYAVQKrneflersnketVGPITVHDRSGGCQAGTFCALSTLHQ
               ..    .  .... .. . |...|.  ||| . | ..  .|. ....             ||. || ..|    ||..||  | .
d..............yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld............ggpvlvHCsaGkdRTGtvvallllll

EMIHEEAVD--------IYKTVKLYAAKRPNLITSREDYYYLFKALQS
 . .|  ||        ....|.   |.||. . . | |..|..||. 
gvsletivddYlltnlyleeaveelraqrpgavqteeqylflyealle

0049772 (Phosphotyrosine protein) phosphatases II 961-1214 1.1e-23 79.9 In-house 40-277 (314) alignment
Range on Protein: 961-1214
Range on HMM: 40-277/314.0
FSKARQSKHKNRDMDLIPVErSRVPISGVPGVD-GYINASFLQGYrrqNEYIVTQYPSAETMEDF----------WKML--WEHNSTTIVT---------
...    ..||| .| .|.. .|| ..|.|. . .|||||.. |.   . .|.||.|. .|..||          |.|   ...|. .||          
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTDDQKEDepiywptNVDEPLTLGALTitlwkrntlispssqgkflgqssqgthtplviqnKEF--DDDDQLNVRQYHCSYWPDCCSP
            |..            |   . .|  |                                   .|   ... . .. .|..  .|| . |
lsrLdaAlgKtpllildgng.......neptaadlellk..................................eelydpelferlgikylripvpDgsap

LHTAFDLIYavqkrnEFLERSnkETVGPITVHDRSGGCQAGTFCALSTLHQEMiheeAVDIYKTVKLYAAKRP-----NLITSREDYYYLFKALQ
|   || ..      ||.|.   .. ||. || ..|   .|||...  |   .     |.. .... . .|||     ..| . |.|.. ..||.
lledfdefl......efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileall

subfamily_PTPN3_pd Subfamily PTPN3 946-1213 1.4e-23 78.2 In-house 19-271 (280) alignment
Range on Protein: 946-1213
Range on HMM: 19-271/280.0
EQFNLIMKMKP-RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGvdGYINASFLQ----GYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT
 ||. . . || .. . ..  .  .|||  |..| .  || ..  .    ||||....    .    | ||.|| | |.|..|||.|.||..|..|| ||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

DDQKE---DEPIYWPTnVDEPLTLGALTITLWKRntlispSSQGKFLgqssqgtHTPLVIQNKEFDDDDQLNVRQYHcsYWPDCCSPLHTAfDLIYAVQK
.   .       |||.  .. |..| ..... |.      ... ...          ||...|| ... ..   ||    ||| . | ..| |..  |..
tlverGrvkChqyWPe.tedeleygefsvkceke......detksyv.......lrelvlkdketkeerkilqlqyl..aWpdhgvPddsa.dflefver

RNEFLersnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ..      . .  |. ||  .|  ..| . .| |  . . ..|.| . . |.    .| .|. . . | .. .|.
vrklr....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_PTPN1_pd Subfamily PTPN1 958-1202 2.3e-23 77.4 In-house 21-256 (290) alignment
Range on Protein: 958-1202
Range on HMM: 21-256/290.0
DYEF--SKARQSKHKNRDMDLIPVERSRVPISGVPGvdGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWP
|..   .|  . . .||  |. | . ||. .        |||||...  . . .||.|| | ..|.. ||.|.||..| ..| |    . ..     |||
dfptreaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

TNVD-EPLTLGALTITLwkrnTLISPSSQGKFLGQSSQGTHtplviqnkeFDDDDQLNVRQYHCSYWPDCCSPLHTAFDLIYAVQKRNEfleRSNKETVG
.. . . |.|   ....    .|||  .. ..  .  . .             ..  .. ..|   |||   |   |  | .  . |.     | .. ||
qgeeekellledtklkv....kliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvres...GslssdvG

PITVHDRSGGCQAGTFCALSTLHQEMIHEE---AVDIYKTVKLYAAKRPNLITS
|  .|  .|  ..|||| . |.  .. ...   .||| |..      |  ||  
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqt

0046846 (Phosphotyrosine protein) phosphatases II 986-1213 1.5e-22 75.7 In-house 5-169 (176) alignment
Range on Protein: 986-1213
Range on HMM: 5-169/176.0
ISGVPGVDGYINASFLQGYRrqneYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEPLtlgaltitlwkrntlispssqgk
..| ..   ||||... |.|    .|.||.|  .|..||..||.|.. |..|.||...  .    | |||   .. .                       
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

flgqssqgthtplviqnkefddddqlnvrQYHCSYWPDCCSPLHtaFDLIYAVQKRNEFLERSnketvGPITVHDRSGGCQAGTFCALStlhqEMIHEEA
                             ||..  ||| . | .   .|. ...  .|.|..      ||. || . |   .||..|.      ...|  
.............................qylhlpwpDhgvpdl..elllellefirealkeg.....gpvlVHCsaGigRtgtlvaay....llelekg

VDIYKTVKLYAAKRP-NLITSREDYYYLFKAL
........|. ..|| . ....| |..| ...
lsveealalvreqRplgavqtpeQyrflyefe

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 717-908 5.7e-22 72.9 In-house 3-198 (199) alignment
Range on Protein: 717-908
Range on HMM: 3-198/199.0
RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG-TPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVPERRVYHF
 |. ||||| .|. |. |||..|||  |  |||.   .         |||.   .  .|  | || .     . ||. ...|            | . |.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt..appstreishy

HYTDWPDHGVPPYTLPVlSFIQR----SSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE--EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
 .| | ..  |  .| |  |.      |   .     |.||||| | | || .. .|  ..  .      |..|   ||.|  |  .. . ..| ||..
qftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 718-908 6.8e-22 72.6 In-house 3-197 (198) alignment
Range on Protein: 718-908
Range on HMM: 3-197/198.0
QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG-TPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVPERRVYHFH
|. ||||| .|. |. |||..|||  |  |||.   .         |||.   .  .|  | || .     . ||. ...|            | . |. 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt..appstreishyq

YTDWPDHGVPPYTLPVlSFIQR----SSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE--EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
.| | ..  |  .| |  |.      |   .     |.||||| | | || .. .|  ..  .      |..|   ||.|  |  .. . ..| ||..
ftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 962-1132 1.2e-21 71.6 In-house 40-156 (392) alignment
Range on Protein: 962-1132
Range on HMM: 40-156/392.0
SKARQSKHKNRDMDLIPVERSRVPI---SGVPGVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDepiywptnvdep
..    ..|||  . .| ...|| .     .|  | |.|||.....  .. || .| | | ...|||.|....| |||. .|. .. |            
aqkeinlkknryknilpydsarvkleviddipdsd.ylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

ltlgaltitlwkrntlispssqgkflgqssqgthtplviqnkefDDDDQLNVRQYHCSYWPDCCSPLHTAFDLI
                                              ||.  | |.| . |||   | ||.  | 
............................................kgddartvaqfhftewPdkdvpkhtssllk

subfamily_PTPN14_pd Subfamily PTPN14 948-1213 1.4e-21 71.8 In-house 29-292 (300) alignment
Range on Protein: 948-1213
Range on HMM: 29-292/300.0
FNLIMKMKP-RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVP-GVDGYINASFLQGY--RRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDD-
.. |.|..   ... .|  . ..|||. |..| | .|| .|      .|||||| ..     .. .|||.| |   |..|||.|.||.. . || ||.. 
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

--QKEDEPIYWPTNVDEPLTlgaLTITLWKRNTlispssqgKFLGQSSQGTHTPLVIQNKEFDDDDQLNVRQYhcSYWPDCCSP--LHTAFDLIYAVQK-
   ||    |.| . ..  |   ..   .|  |        ||  .|.. . | | ..     .. ..   ||    |||   |  ... .. .  ||  
edgkeksfkyfPkleskkkt...vefgkfkvtt........kfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsv

--RNEFLERSnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
  . .    | ||.  |. ||   |. ..|       | . . |.| .|| |...    .|  |. .   | ...|.|
rrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 631-726 3e-20 66.2 In-house 4-95 (95) alignment
Range on Protein: 631-726
Range on HMM: 4-95/95.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQplpGIPNSDYINANYIDGFNRQKAYIATQG
 ||.| | |||.  |.|||  |  |.  |.   .  | |  |   |  |||. ||. ||..|| |       .|||||| ..||. |...|||.||
pihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 726-906 1e-19 65.2 In-house 98-280 (302) alignment
Range on Protein: 726-906
Range on HMM: 98-280/302.0
GALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTP-ERYNELEV-TLELKEKFASYTL----RTFLLKHRHKKHGKVPERRVYHFHYTD
   | | . .| |. . .  ..| .... | . .||  |.  |     ....  | |...|.... .|     . . .. . .|. |  .. |  .... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPPYTLPVLSFIQRSSAANpTDagpIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFI
||||| |  . . |  ..   .   ..   ..|||||||||||| . |   ..  . ..  ..   .. .|. |   ||.|.| ...
wpdhGapkeaytaldilkfcesyk.kn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 723-914 1.5e-19 65.1 In-house 39-221 (255) alignment
Range on Protein: 723-914
Range on HMM: 39-221/255.0
AtqgalktTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgKVPERRVYHFHYTDWPD
        | | |.. .  .|. |.||.. ..| |. ||..|.| .   |.    .|..   .  |   |||  .     .  |   . | |..|. |..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekd.eklkladvnvtttkssadvvlrtleitstlge..kkkthtvkhysykGWie

HGVPPYTLPVLSFIQRSsaanpTDAGPIIVHCSAGVGRTGTYIVID----TMLKQMQAEEKVNV--FGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
.  |  .  .|  ..       .|. ...||||.|.||. ......    .|.....  | |..    .|. .| .|.  ..|  |  |   ..|...
knaPelareilnilkvv.....rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 677-922 1.9e-19 64.9 In-house 20-268 (290) alignment
Range on Protein: 677-922
Range on HMM: 20-268/290.0
KLKNRYTNIVsYDSSRVSLQPLPGIPNSDYINANYIDgFNRQKAYIATQGA-------LKTTFDDFWRLVWEQKSVVIVMITKLEERGRR----KCDRYW
....|... .    .|| |.      |.||| ||..  .    . |.||          . |  .|| .. . |.  .||. . ||. .      | .| 
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PAK-GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSaanpTDAGPIIVHCSAGVGRTGTY
| . |.  ... |.|    |||      |. ..|.  ..     |  | |  . .| .  |.. |. .|| ||       .   |.||||  |. |  . 
pesvgeelkfkgltvkCkskekeddvetRelvvkfddee.....eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAal

IVIDTMLKQMQ-AEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVL-LEWLRAGNTVVK
  |.     .   ...|..   || .| ||. ........ |.  .. |   ........
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfae

0044763 (Phosphotyrosine protein) phosphatases II 981-1215 4.2e-19 64.3 In-house 4-169 (178) alignment
Range on Protein: 981-1215
Range on HMM: 4-169/178.0
RSRVPISGVPGVDG--YINASFLQGYrrqneYIVTQYPSaetmEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDepltlgaltitlwkrntli
|.|| .| ..|. .  |||||.  ..     ......|.    .|....|.|.. |.||.||...    .... |||.. .                   
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

spssqgkflgqssqgthtplviqnkefddddqlnvRQYHCSYWPDCCSPlhtafDLIYAVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQ
                                    ||..  .|| . |     ||.  ...  ||.|.  .|  ||. || . |   .||..|.  ...
...................................iqylhipipDhgvp.....dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkk

EmiheeAVDIYKTVKLYAAKRPnLITSREDYYYLFKALQS
       ..... ..|. ..||  .........| .  . 
l.....glsleeaielvrerRp.ivpnpgqlrqLyefelr

0051082 (Phosphotyrosine protein) phosphatases II 993-1212 4.2e-19 64.1 In-house 3-148 (151) alignment
Range on Protein: 993-1212
Range on HMM: 3-148/151.0
DGYINASFLQGYrrqneYIVTQYPsaetMEDFWKMLWEHNSTTIVTLTDDQ-KEDEPIYWPTNVdepltlgaltitlwkrntlispssqgkflgqssqgt
..|||.|.. |.     ......|    ..||...|.|.. .|||.|....  . .| |.| .                                     
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeergycpeylpelg....................................

htplviqnkefddddqLNVRQYHCSYWPDCCsplhtafdLIYAVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEmiheeaVDIYKTVKL
                ..|.....  |||          |    .  .||||  ..   ||. || ..|    ||..||  ...       |....... 
................ievlhipildwpdpg........lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealee

YAAKRPNLITSREDYYYLFKA
| .|||..... . ......|
yrlkrpgvvqpnqqflfqlfa

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1006-1211 1.4e-18 61.8 In-house 3-198 (199) alignment
Range on Protein: 1006-1211
Range on HMM: 3-198/199.0
RQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEPLTLGALTITLwkrntlispssqgKFLGQSSQGTHTPLVIQNKEF
 |  ||.||.|  ||| |||.|.||  |  || . ||||. |   |.||||        |.|..|              | .   .. | | |.. |.  
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt.............ktittkpdytitaliltnntt

DDDDQLNVRQYHCSYWPDCCSPLHTAFdLIYAVQKRnEFLERSNKETVGPITVHDRSGGCQAGTFCALSTL--HQEMIHEEAVDIYKTVKLYAAKRPNLI
      .. .|  . | .  .|  . | . . |  | |   . ..|   |. ||   |   .| | ||      .|  .   ||...  |     |  .|
appstreishyqftswkekttpnvalf.vgfvvasr.evskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii

TSREDYYYLFK
.| . | ....
sslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1007-1211 2.9e-18 60.8 In-house 3-197 (198) alignment
Range on Protein: 1007-1211
Range on HMM: 3-197/198.0
QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEPLTLGALTITLwkrntlispssqgKFLGQSSQGTHTPLVIQNKEFD
|  ||.||.|  ||. |||.|.||  |  || . ||||. |   |.||||        |.|..|              | .   .. | | |.. |.   
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt.............ktittkpdytitaliltnntta

DDDQLNVRQYHCSYWPDCCSPLHTAFdLIYAVQKRnEFLERSNKETVGPITVHDRSGGCQAGTFCALSTL--HQEMIHEEAVDIYKTVKLYAAKRPNLIT
     .. .|  . | .  .|  . | . . |  | |   . ..|   |. ||   |   .| | ||      .|  .   ||...  |     |  .|.
ppstreishyqftswkekttpnvalf.vgfvvasr.evskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SREDYYYLFK
| . | ....
slqhynfiyq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 964-1070 4.1e-18 59.9 In-house 93-197 (244) alignment
Range on Protein: 964-1070
Range on HMM: 93-197/244.0
ARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEpiYWPTNvdEPLTL--
  .. .|||.   .|.. .|||.|     . ||||||.    |  |||.||.| |.|  |||||. |     .| |   ..|||  |||    |||    
npnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede..ywpds..eplewye

GALTITLWK
  .|.||  
editvtltd

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 662-921 4.2e-18 60.0 In-house 31-285 (303) alignment
Range on Protein: 662-921
Range on HMM: 31-285/303.0
VPTSFPATF--SSDVENKLKNRYTNIVSYDSSRVSLQplpgipNSDYINANYIDgFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRR
| . .| .      |.|  |||.....  | |.| |       .| || |.|.. .. .|  | ||  |  |  |||... |||  .....    |  . 
vvsylppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydkl

KCDRYWPAKGTPERYNELEVTLelKEKFASYTLRTFLLKHRHKKHGKVpERRVYHFHYTDWPDHGVPPYTLPV--LSFIQ-RSSAANPTDAGPIIVHCSA
  |  .| .    ...|  . .   |         . ||      |.     ..  || .||   .|  . |       | .|   . .|. | .    .
ggdsvfprnqdflkfeersirv..gefkrvelgdgwvlkvlsvsngdy.ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GVGRTGTYIVIDTMLKQMQAEE-KVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRaGNTVV
|.||.||. ...|    ...|.  ...   |. .|  | . ||   |. ... .| | .  .| ..
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl.dngic

PTPc_DSPc_SM00012 1110-1214 4.2e-18 60.8 In-house 2-104 (105) alignment
Range on Protein: 1110-1214
Range on HMM: 2-104/105.0
VRQYHCSYWPDCCSPL--HTAFDLIYAVQKRNEFLERsnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHE-EAVDIYKTVKLYAAKRPNLITSREDY
|..||.. |||.. |   .  ..|. ||.| ..  |.      .|. ||.. |  ..|||.||..|.| . .| . |||...|| .  .||..... |.|
vkhyhytgwpdhgvPeesdsilellravkknknkses.....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy

YYLFKALQ
 .| .||.
lflyrall

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 653-916 8.2e-18 58.8 In-house 29-287 (302) alignment
Range on Protein: 653-916
Range on HMM: 29-287/302.0
AAEYEEIQHVPTSFPAtFSSDVENKLKNRYTNIVSYDSSRVSLQPLPgipnSDYINANYIDGFNRQKAYIATQGALKTTF---DDFWRLVWEQKSVVIVM
 .|...|... ..     ..  .|  ||. ...  .|| .| |.  |     .|.||  ..  . ..  | .| . ...    ..|||.|...| | .|.
kkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi

ITKLEERGRrKCDRYWP-AKGTPERYNELEVTLELKEKFASYTlRTFLLKHRHKKHGKVPERRVYHFHYtdWPDHGVPPYTLPVLSFIQRS-SAANPTDA
. . ||  .   . ..|   |. . |... |     ||    .   . .    .     .   ||....  |... ||     .   ..       ..|.
lvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakkikade

gPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRA
 ....    |.|| |. ..  . ....|.....|.   .| ||.||   |.. .|||... .|| ... 
.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 967-1213 4.9e-17 56.5 In-house 56-279 (290) alignment
Range on Protein: 967-1213
Range on HMM: 56-279/290.0
SKHKNRDMDLIPVERSRVPISG-VPGvdGYINASFLQGYRrqNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNVDEPLTLG
  .|||  |..  ...|| ..   .|   |. | ...| .    .|.|| . ..|. |.|.|. ... ..|| |    .| |     |.| .  | ||.|
efkknrykdvvcndktrvilkdGydG..dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

ALTITLWKRNTlispssqgkflgQSSQGTHTPLVIQNKEFDDDDqlNVRQYHCSYWPDCCSPLHTafdliYAVQKRNefleRSNKETVGPITVHDRSGGC
..|..  . ..            . ..  .  | ...|.   .    .. ..   ||| . .| |      |. .      |. ... ||..||  .|  
eitvlcseedd............kdaniikktlsvrdkdsGkeh..klkhlkikswpdksvalst.....lallrtl....rilrkasGpvvvhcsaGiG

QAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
..||| |. .  | ...  ..|. ..|.     | | .    .|  | ..|
rtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 962-1212 6.1e-17 56.6 In-house 3-236 (239) alignment
Range on Protein: 962-1212
Range on HMM: 3-236/239.0
SKARQSKHKNRDMDLIPVERSRVPIS---GVPGVDgYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTN
.| |  | |||  ...  ..||| .      |  | |||||.|. |    . || ||   . .  |||.|.|.     || ||   . .|.    ||| .
akkrvnkaknryanivtydhsrvvleklsndphsd.yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

VDEpltLGALTITLWKRNTLISPSSQGKFLGQSSQgthTplviqnkefdddDQLNVRQYHCSYWPDCCSPLHTAFDLiyAVqkRNEfLERSNKETVGPIT
  .      | .|| | . .     .   . |  |   |            ..  | ||| . |||   | ...  |   .  | . . . .     |  
tsk...ycnlrvtlrktevfadyiirtfvmsqvgq...t............eeryvyqyhftvwpdkgvpqyatavl..gl..rrk.itkdslpgarpwv

VHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
.|  .|  ..|.|  . .. ..  ....|||.. ||     || .. . |.| ... |
ihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 963-1212 9.2e-17 56.0 In-house 3-235 (239) alignment
Range on Protein: 963-1212
Range on HMM: 3-235/239.0
KARQSKHKNRDMDLIPVERSRVPIS---GVPGVDgYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNV
| |  | |||  ...  ..||| .      |  | |||||.|. |    . || ||   . .  |||.|.|.     || ||   . .|.    ||| . 
kkrvnkaknryanivtydhsrvvleklsndphsd.yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

DEpltLGALTITLWKRNTLISPSSQGKFLGQSSQgthTplviqnkefdddDQLNVRQYHCSYWPDCCSPLHTAFDLiyAVqkRNEfLERSNKETVGPITV
 .      | .|| | . .     .   . |  |   |            ..  | ||| . |||   | ...  |   .  | . . . .     |  .
sk...ycnlrvtlrktevfadyiirtfvmsqvgq...t............eeryvyqyhftvwpdkgvpqyatavl..gl..rrk.itkdslpgarpwvi

HDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
|  .|  ..|.|  . .. ..  ....|||.. ||     || .. . |.| ... |
hcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_ptpA1_pd Subfamily ptpA1 957-1176 3.7e-16 53.9 In-house 37-255 (418) alignment
Range on Protein: 957-1176
Range on HMM: 37-255/418.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRrQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQkEDepIYWPTN
 .      ..   |||  ...||...|| .  .   .|  |||| ...|    ...|.|| |  .|. |||.|.||     || |. .  |.       .
setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsres.en..crikcd

VDEPLTLGALTITLWKRNTLISPSsQGKFLGQSSQGTHTPLVIQNKEFD-DDDQLNVRQYHCSYWPDCCSPLHTA--FDLIYAVQKRNEFLERSNKETVg
   |  .|   ....     .  .     | .  |     .. .|  .  . .  .. ||.   |||   | ||    .|.... .|.. .  |.   | 
rywpeqiggeqfsiygngnevfgt.ysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnv.

PITVHDRSGGCQAGTFCALSTLHQE
|| ||  .|  ..||||.   . ..
piivhcsagvgrtgtfctavimmkk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 670-780 6.1e-16 52.7 In-house 42-164 (349) alignment
Range on Protein: 670-780
Range on HMM: 42-164/349.0
FSSDVENKLKNRYTNIVSYDSSRVSL----QPLPGIPNS----------DYINANYID--GFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKL
.|. ||   |||| .|. |. ||| |    ..  .| .|          |||||||.    .. .| |||||  | .| |||....  ..  ... ... 
lseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

EERGRRKCDRYWPAKgtpeRYNELEVT
.| . .|||.||        |.. .| 
kelslekcdiywqel....sysnitvk

subfamily_PTPRN_pd Subfamily PTPRN 954-1055 1e-15 52.2 In-house 43-150 (297) alignment
Range on Protein: 954-1055
Range on HMM: 43-150/297.0
MKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVP--GVDGYINASFLQG-YRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDE
 .|.  | .|| .  .|||  ...| . ||| ..       . |||||..     |.  || || | |.|. |||.|.||. .. ||.||  ..   . .
aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

PIYWPTNV
  ||| . 
krywpdeG

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 851-917 1.5e-15 51.4 In-house 2-68 (69) alignment
Range on Protein: 851-917
Range on HMM: 2-68/69.0
IVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
.||||.| |||||.| |   . ....|  |..|  .. .|  |  .|  | .|.|||| | | |. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 851-917 4.8e-15 49.7 In-house 1-67 (69) alignment
Range on Protein: 851-917
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
.||||.| |||||.| |   . ....|  |..|  .. .|  |  .|  |..|.|||| | | |. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 950-1065 5.7e-15 49.9 In-house 16-136 (297) alignment
Range on Protein: 950-1065
Range on HMM: 16-136/297.0
LIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGY--RRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---K
|. . .. ..  .|   | .|||  |.. .. .|| . .|.    |||| ..       .  ||..| |  .|..|||....|..  .|| ..  |   .
lldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

EDEPIYWPTNVDEPLTLGALT
.    |||  |.| |. | . 
dkcapywpsvvqerlkagdvv

subfamily_CG42327_pd Subfamily CG42327 966-1071 5.8e-15 49.8 In-house 27-140 (319) alignment
Range on Protein: 966-1071
Range on HMM: 27-140/319.0
QSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED---EPIYWPTNVDE--
 || |.| .. .|.  .||    ..    | |..||...||.  .| || .| .  ..  |||...|| .| .||.||| ..      . |.||.     
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

PLTLGALTITLWKR
  . | . .|| .|
tslyGdilvtlkgr

subfamily_hpo-7_pd Subfamily hpo-7 723-913 1.3e-14 48.8 In-house 42-226 (263) alignment
Range on Protein: 723-913
Range on HMM: 42-226/263.0
AtqgaLKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK-GTPERYNELEVTLelKEKFASYTLRTFLLKHRHKKhgKVPERRVYHFHYTDWP
     |  | | |.. .  .|. |.||..  .| |. ||..|.| .     ......|.    .      |.|  |    ..  |   . | |. |. |.
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct..tkvqsdvllktlellstlge..KkkthtvkhysykgWi

DHGVPPYTLPVLSFIQRSsaanpTDAGPIIVHCSAGVGRTGTYIVID----TMLKQMQAEEKVNV--FGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
..  |  .  .|  ..       ..  ...||||.|.||.  . |..    .|.....  . |..    .|. .| .|.  ..|  |  |   ..|..
ekndpelareilnilkva.....rnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf

subfamily_CG42327_pd Subfamily CG42327 843-913 3.9e-14 47.0 In-house 243-314 (319) alignment
Range on Protein: 843-913
Range on HMM: 243-314/319.0
NPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE-EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
.  . ||..|||| ||||||. |  |  .....   . |..   .  .| .|   |.| ||| ||. || |.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 812-913 5e-14 46.8 In-house 217-343 (350) alignment
Range on Protein: 812-913
Range on HMM: 217-343/350.0
VYHFHYTDWPDHG---VPPYTLPVLS----FIQRSSAANP---TDAGPIIVHCSAGVGRTGTYIVIDTMLK-----QMQA----------EEKVNVFGFL
||....  |.| .    |   |..|     .|.   | .      . ||.||||||||||||.. .| .|.     ..            . .  ..  .
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KRIRTQRNYLVQTEEQYVFIHDVLLEW
...| ||  .||. .|..||.. || .
nelrkqrismvqnldqfifiYeallfy

fn3 Fibronectin type III domain 171-244 5.1e-14 45.4 Pfam-A 2-76 (85) alignment
Range on Protein: 171-244
Range on HMM: 2-76/85.0
PPGEPKALKINSTSLVLSWLPS---DGPISNYSVSVRKGNYTSsWDLAVNQPPGASsEYTVYGLMPYEFYQFHVRAH
.|. ...  ..||||.||| |.   .|||..|.| .|. . .. ..  .. |. .. ..|. || |.  |.| |.|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprttt.svtltgLkpgteYefrVqav

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 957-1179 5.4e-14 46.7 In-house 37-292 (350) alignment
Range on Protein: 957-1179
Range on HMM: 37-292/350.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPIS-----------GVPGVDgYINASFLQGY----RRQN--EYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
 |...|.  ..  |||  ...| |.||| .             . . | ||||..|.      . .    || || |  .|..||.|.. . . . |..|
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

TDDQK---EDEPIYWPT-NVDE-PLTLGA--LTITLWKRNTLISPSSQGKFL-----GQSSQGTHTPLVIQNKeFDDDDQLNVRQYHCSYWPDCcSPLHT
|.|.    |   .||.  ..|.  . | .    |.  .  .| |   ....       .  .  .   ... .     | . | | .   |.|  | |  
tsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltait.laasdPyvvyqlqvknWkDl.sllln

AFDLIYAVQKRNEFLER------SNKETVGPITVHDRSGGCQAGTFCALSTLHQEM-IH
  ... |.. .|....       ....   || ||  .|  ..||...|  | ... | 
PesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeil

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 839-914 6e-14 46.6 In-house 221-295 (297) alignment
Range on Protein: 839-914
Range on HMM: 221-295/297.0
SSAANPTDAgPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
  |. | .| ...|||||||||.|  .  |..|.... .   .|  .|. .| ||  |||| ||. ...|. |. |
lraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 939-1214 6.5e-14 46.6 In-house 13-274 (307) alignment
Range on Protein: 939-1214
Range on HMM: 13-274/307.0
VGRVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVT
 |   | ..|. . |..|        .   .|||  |.  ....|. .        || | .|    . . .|..| |  .|. .|| |  ...  ... 
kgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTD---DQKEDEPIYWPTNVDEPLTLGALTITLWKRNTlispsSQGKFLGQSSQGTHTPLVIQnkefDDDDQLNVRQYHCSYWPDCCSPLH--TAFDLIY
| .     |     ||| .  . |. |  . |.   |        .|.  .      | | ..      ..   ....  . |||   |    || .|. 
lckvielakikceqywpleegqklvfgeapntisvanl.....gakklapdedlinvttlkvd....waqksrtiqhlqwenwpdrgvpqinltainlle

AVqkrneflersNKETvGPITVHDRSGGCQAGTFCALSTLHQEMIHE-EAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
||          . .|  |. ||  .|  ..||  |.| . . ||   .  |. | |.   ..|.  | .   | || . | 
av..........rydt.npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll

subfamily_egg_pd Subfamily egg 961-1074 8.1e-14 46.0 In-house 41-152 (307) alignment
Range on Protein: 961-1074
Range on HMM: 41-152/307.0
FSKARQSKHKNRDMDLIPVERSRVPISGvpgvdGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK-EDEPIYWPTNVDEPL
  |||. . . .|.  . .|  |   ..      .| |  ..|    ||.|..| |  .|..|||.|... .   || ||  .. |  . |||   ...|
lekarskrvhckdssrvklelrrGqyld.....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdsl

TL--GALTITLWKRNTL
 .  |.| |.  | .  
vtvpGslrienlkvdsk

subfamily_eak_pd Subfamily eak 673-828 8.8e-14 45.6 In-house 49-197 (332) alignment
Range on Protein: 673-828
Range on HMM: 49-197/332.0
DVENKLKNrYTNIVSYDSSRVSLQPLPGiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG-TP
 .|.  .|   .|| ||   | | .     .  ||||  ..  .  . || |  | ..    ||..| ||||  ||.. .  | .  | |.|.| |.   
rleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

ERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvperRVYHFHYTDWPDHGVPPY
 ..  |.|.     | . .  | . |.   . |      ||.|...  | .  .| |
lkfGildverkefvkrniletrllelskGneth......rvlhykvfGwtettlpky

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 960-1054 9.2e-14 45.7 In-house 37-130 (347) alignment
Range on Protein: 960-1054
Range on HMM: 37-130/347.0
EFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKeDEPIYWPTN
. || |  ..|  |   . .   .   |    |..||||| ..    ..|||.||||  .|. |||||.   . | .||. . .| || |   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik.deaieefan

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 673-787 1.1e-12 42.1 In-house 93-201 (244) alignment
Range on Protein: 673-787
Range on HMM: 93-201/244.0
DVENKLKNRYTNIVSYDSSRVSLQPlpGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrrkcDRYWPAKGTPE
. .|  |||    . .| .|| |    |     |||| ..  . |   || ||  |  |  |||... |..  |.|..  .||      | |||     |
npnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseple

RYNE-LEVTLELKEKF
 |.| . |||  ...|
wyeeditvtltdrdef

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 664-761 1.4e-12 41.8 In-house 22-118 (332) alignment
Range on Protein: 664-761
Range on HMM: 22-118/332.0
TSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGipNSDYINANYIDGFNRQKAYIATQGALKT-TFDDFWRLVWEQKSVVIVMITKLEERGRRKC
 ..| |.   ..|   ||   .  .| ||| | |  |  . |. ||...||.... ||| .|  ..  |   |||.| |.|  .|...  ..|. .||.
mtypntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 947-1211 9.4e-12 39.3 In-house 33-281 (305) alignment
Range on Protein: 947-1211
Range on HMM: 33-281/305.0
QFNLIMKMKprdyEFsKARQSKHKNRDMDLIPVERSRVPISGvPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK--
.|| . |||     | |  | ..|||  |.  ... || . | |    || | ..      . .| || |  .|  ||| | ....  .|  | . ..  
rfndfekmk....af.keaqeagknrykdvgcldnnrvkleg.pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekg

-EDEPIYWPTNVDEPLTLGALTitlWKRNTLISPSSQGKFLGQSS-QGTHTPLVIQNKefdDDDQLNVRQYHCSYWPDCCSPlhTAfDLiyAVQkrnEFL
 .    |.... .. |..        |    .  |.. ||  ... . |.| |||.       ... | .||   |||   |  .| ||  |.    |.|
akkcleyfaskdkdvlefeekg...qkisvkfessvtlkfrkdakakvtetvlviegp...gekarkvthyhwidwpdrgvp..aa.dl..ail...ell

ERSnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVD-IYKTVKLYAAKRPNLITSREDYYYLFK
|.. . . |||.||  .|  ..|.   |  . ....  . ..   | ..    .| | | . ..| .. .
eka.rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 967-1214 1.5e-11 38.8 In-house 35-267 (285) alignment
Range on Protein: 967-1214
Range on HMM: 35-267/285.0
SKHKNRDMDLIPVERSRVPISGVpgVDGYINASFLQG-YRRQNEYIVTQYPSAETMEDFWKMLWEHNSTT---IVTLTDDQKEDEPIYWPTNVDEPLTLG
    ||  |.  .| .|| .        || ||...   . |. || || |  ||. |||.|... . .    ..|| .   |   .|.| .. | . .|
npdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

ALTITLWKRNTlisPSSQGKflgqssqgTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHtAFDLIYAVqKrneFLERSN-KETvgPITVHDRSGG
   ||| . .     .  |             | . | |    . | . . .  .|||  .|   |  .|    |   .... | ||.  || ||  .| 
kyeitltecke...eaiagt........ilnaltvintedasseplymnhvqvpwwpdqlaped.arpmiely.k...wvkkvnpkek..picvhcsagv

CQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 .. ||  .      .. .  ...   |.   | | . . |. .. .|.  | 
grtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 664-716 1.8e-11 38.0 In-house 35-87 (440) alignment
Range on Protein: 664-716
Range on HMM: 35-87/440.0
TSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN
 | |.  .|  .||.|||| ||..|| ||| |. . |.|.|||||| ||.| .
lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 960-1195 3.4e-11 37.3 In-house 45-268 (310) alignment
Range on Protein: 960-1195
Range on HMM: 45-268/310.0
EFSKARQSKHKNRDMDLIPVERSRVPISG-VPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEPI---YWPTnV
 .   ..  ||||  |..  . ||| .       . || | ...    .. .|..| |   |. |||.|...  . .|. |    .|  |    |||. .
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.l

DEPLTLGALtitlwkRNTLISPSSQGkFLGQSSQGTHTPLVIQNKE-FDDDDQLNVRQYHCSYWPDCCSPLHTAfdliYAVQKRneFLErsnKETVGPIT
    | | .      | | .| ||.  |       |  |  .   |   . ..| |   .   |||.  |        ..| .|  .|    .   ||  
gvtetygci......rvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc....htvpqr..lla...qvrhgpcv

VHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAK
||  .|  . .. .||    . . . . ||. . .  .  .
vhcsagkdrlyvvvalklkidkldrglkvdaeevktellks

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 985-1071 5.7e-11 36.8 In-house 11-89 (130) alignment
Range on Protein: 985-1071
Range on HMM: 11-89/130.0
PisgvpgVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEpiYWPTNvdEPLT--LGALTITLWKR
.       . ||||||.    | .||. || | |.|  |||||. |     .| |   ..|||  |||    |||      ...|| .|
q......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede..ywpds..ePlewyeediivtltdr

0048076 (Phosphotyrosine protein) phosphatases II 1028-1213 6.4e-11 37.6 In-house 25-139 (145) alignment
Range on Protein: 1028-1213
Range on HMM: 25-139/145.0
LWEHNSTTIVTLtddqkedepiywptnvdepltlgaltitlwkrntlispssqgkflgqssqgthtplviqnKEFDDDDQLNVRQYHCSYWPDccsplHT
|.... ||...|                                                                ..   .. ||..  |||     |.
lkdlgittvlnl............................................................tselellerlgiqylylpwpD.....hg

AFDLIYAVQKRNEFLERSNKETvGPITVHDRSGGCQAGTFCALSTLHQemiheEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
..||.  ...  ||.|.  ||  ||. || . |   .||..|.  ...     . |.......|. ..||. ... . ...|....
vpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 1025-1211 1.7e-10 36.3 In-house 22-139 (144) alignment
Range on Protein: 1025-1211
Range on HMM: 22-139/144.0
WKMLWEHNSTTIVTLTDDqkeDEPIY---WptnvdepltlgaltitlwkrntlispssqgkflgqssqgthtplviqnkefddddqlnVRQYHCSYWPDC
...|.... ||...||..    || .                                                              . ||..  ||| 
lellkklgittvinltee...yepeflere..........................................................giqylhlpwpDh

CSPlhtafDLIYAVQKRNEFLERSNKETvGPITVHDRSGGCQAGTFCALSTLHqemihEEAVDIYKTVKLYAAKRPNLITSREDYYYLFK
. |     ||.  ...  ||.|.  .|  ||. || . |   .||..|.  ..     .. ........|. ..||. ..... ...| .
gvp.....dllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_eak_pd Subfamily eak 969-1067 2.4e-10 34.3 In-house 54-155 (332) alignment
Range on Protein: 969-1067
Range on HMM: 54-155/332.0
HKNrDMDLIPVERSRVPI-SGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLTLGAL
..|  ....| .|  | . |     .|||||| ..     ..||.|  .| . .  ||.|. | .| .|| | .| .   |    |.| .  | |  | |
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

TIT
 ..
dve

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 713-804 3.2e-10 33.9 In-house 230-318 (440) alignment
Range on Protein: 713-804
Range on HMM: 230-318/440.0
DGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrrKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKH
.|. ...|.||||  | .|  |||||| . .   |.|. .|...    |  ||| .     .  . |     |..    .||. ||.. . |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevh

fn3 Fibronectin type III domain 457-531 3.9e-10 32.9 Pfam-A 1-77 (85) alignment
Range on Protein: 457-531
Range on HMM: 1-77/85.0
SEPHNITITVIGPGTARISWMEPFIFYNSIDSYTVSYRDINVSTPMLAAEITNTS--RLLRNLQDDATYEVTVRAFT
|.|.|.... ... ....|| .|.     |..|.| ||. . . .     ...|.    |..|. ...||..|.| .
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn

fn3 Fibronectin type III domain 269-350 4.6e-10 32.7 Pfam-A 2-85 (85) alignment
Range on Protein: 269-350
Range on HMM: 2-85/85.0
PPGNVTVTTRGPFTIAVSWKPPPpnSINGVLQNYKVMVSPG-----SQVIKLGPSTLSTVITNRKPFTLYIVTIAVVNSANeTGPFS
.|.|..|. ... .. .||.||.  . .| ...|.| ...      .. ... ..| | ..|. || | | .... || |  .||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag.egpeS

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 968-1057 4.6e-10 33.6 In-house 38-133 (281) alignment
Range on Protein: 968-1057
Range on HMM: 38-133/281.0
KHKNRDMDLIPVERSRVPISG-VPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNVDE
..||| ...  .. ||| .   .|      || | ...    .  ||.|| |  ||  |||.|.|. |.|.|| |    . ..|    |.| |   
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

subfamily_eak_pd Subfamily eak 834-923 5e-10 33.3 In-house 225-314 (332) alignment
Range on Protein: 834-923
Range on HMM: 225-314/332.0
SFIQRSSAANPTDAgPIIvHCSAGVGRTGTYIVIDTMLKQMQAeEKVN---VFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKS
|....   . |. | |||  .. |  |.|...||| ... ...  | |   |  .. .....|.. | .. |. ||....|..|.  |  .. 
stlkkyihtppsfa.pii.qsarGsaraGvfvvidllirlidn.kkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrd

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 989-1209 5.6e-10 33.4 In-house 71-273 (301) alignment
Range on Protein: 989-1209
Range on HMM: 71-273/301.0
VPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDD---QKEDEPIYWPTNVDEPLTLGALTITLWKRNTLISPSSQGKFLg
| |    | | ...   . . .|.|| |  .|.|||| ||  ..  .|| |.     ..|    | |... | | .|  .|.. ....... . . . | 
vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtl.

qssqgthtPLVIQNKEFDDDdqlNVRQYHCSYWPDCCSPLHT--AFDLIyavqkrnEFLERSNKetvgPITVHDRSGGCQAGTFCALSTLHQEMIHEEAV
         ..   ..|.      |  |  | |.|   |      |||.       |.. .|.|    || ||  .|  .. .| .   | .|.  .  .
........evedstgkfatr...tvthyqysewtdrgvPkshaelfdlm.......elvkksek....PivvhcsaGiGrsvafigteylareveadpti

DIYKTVKLYAAKRPNLITSREDYYYL
.. ...|    .| | .  ..  |..
eltealkhlrehrwngvqtnsqlywm

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 958-1185 6e-10 33.0 In-house 39-302 (349) alignment
Range on Protein: 958-1185
Range on HMM: 39-302/349.0
DYEFSKARQSKHKNRDMDLIPVERSRVPISGV----------------PGVDGYINASFLQGYR--RQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
|...|.  ..  |||  |..| | ||| .                     .| |||| .|.  |   .. || || |.  |..||.|..   .   .. |
dvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TDDQKED---EPIYWPTNVDEpltlgALTITLwKRNTLISPSSQGKFLGQSSQGTHTPL---VIQN---KEFDDDDQLNVRQ--------YHCSYWPDCc
.||....     |||     .       |. | .   | . . ||  |  | .    .    . .|    . ||||.... .             |.|  
nddkelslekcdiywqelsys.....nitvkl.qnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldl.

SPLHTAFDLIYAVQKRNEFLERSNK------ETVGPITVHDRSGGCQAGTFCALSTLHQ--EMIHEEAVDI
| |     .. |.. .|....  .       . . .. ||  .|  ..|... |  | .  |. ..| . |
slllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki

0038934 (Phosphotyrosine protein) phosphatases II 796-891 7.1e-10 34.3 In-house 49-160 (194) alignment
Range on Protein: 796-891
Range on HMM: 49-160/194.0
LLKHRHKKHGKVPER--------------RVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTD-AGPIIVHCSAGVGRTGTYIVIDTML-KQMQAEEK
.||....|.|.|                 . ....   .||.|..| .  .|.|..     .  |  | . ||| ||.||||| ..   .   .| ||| 
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA

VNVFGFLKRIRT
.. | . ..   
ialfrekRpgai

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 688-825 9e-10 33.0 In-house 5-126 (130) alignment
Range on Protein: 688-825
Range on HMM: 5-126/130.0
YDSSRVSlqplpgipNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrrkcDRYWPAKGtPERYNELEVTLELKEKF
.. ||.         . .||||...   .| . |. || .|  |  |||... |.   |.|..  .||      | |||    |  . | .... | .. 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdse.Plewyeediivtltdrd

ASYTLRTFLLKHRHKKHgkVPERRVYHFHYTDWPDHGV
 .  ...  |.  ..       . .  |. ..||  | 
efknikasnleiesdln..eshqaltmfqisnwpsdgt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 846-915 8.7e-09 29.2 In-house 264-345 (349) alignment
Range on Protein: 846-915
Range on HMM: 264-345/349.0
DAGPIIVHCSAGVGRTGTYIVIDTMLK--QMQAEE--KV--------NVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
.  ...|||||| ||||... .| .|   ..  .|  |.         ..  .  .| ||  .||   |...|.. ||....
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1001-1066 9.3e-09 29.1 In-house 229-293 (440) alignment
Range on Protein: 1001-1066
Range on HMM: 229-293/440.0
LQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEPIYWPTNVDePLTLGALTI
..|| ..| .| || |   |. |||... ... .||. | . .     |||| |    .|.| .|.
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntr.svtfgpftv

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 967-1213 1.1e-08 29.5 In-house 43-267 (288) alignment
Range on Protein: 967-1213
Range on HMM: 43-267/288.0
SKHKNRDMDLIPVERSRVPISgvPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNVDEPLTLGA
.  ..|  .|   . .|| .|     | ||.|  .   . ..  | .| |   |.| .|||| | .   || |.   .  ||    |.|... |   .| 
nptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

LtitlwkrntlispSSQGKFLGQSSQGTHTPLVIQNKEFDDDDQlNVRQYHCSYWPDCCSPlhTAFDLIYAVQKRNeflersnKETVGPITVHDRSGGCQ
|              .. |   .  . . .  ......  .. .  |.. |   |.| . |    .     . ..        |..  || || . |  .
l.............ctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvP..enylsplrllevl.......kslqkPivvhssaGvGr

AGTFcALSTLHQEM-IHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
.||. .|. .  |.   .. . | . ..   ..| . |..   | |... .
tgtl.ililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1109-1213 3.7e-08 27.1 In-house 90-190 (440) alignment
Range on Protein: 1109-1213
Range on HMM: 90-190/440.0
NVRQYHCSYWPDCCSPLHtAFDLIYAVQKRNEFLErsnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYY
 ..|||   |||   |   |  ..  .|  ||  |   |   ||. ||  .|  ..|   |. .. .|  . . .||.  ..    .||... . |.| .
tlkqyhyqgwpdkgvpkf.agpvlkmiqdvnesqe...kagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

LFKAL
...|.
vheav

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 967-1209 6e-08 26.7 In-house 55-281 (305) alignment
Range on Protein: 967-1209
Range on HMM: 55-281/305.0
SKHKNRDMDLIPVERSRVPISGVPgVDGYINASFLQGY-RRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD---DQKEDEPIYWPTNVDEPLTLg
.. |||  |.   ..| | ..  .    || | ..      .. .|..| |  .|...|| |. ...   || |       |     |||.   | |.| 
aitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel.

altitlwKRNTLISPSSQGKFLGQSSQGTHTplvIQNKEFDDDDQLNVRQYHCSYWPDCCSPL--HTAFDLIYAVqkrnefleRSNKetvGPITVHDRSG
       |   ..   |  | . . ..   |   . |  .  |... ||. . . |||   |    |...|. |.        |  |    || ||  .|
.......ksgivvenvsgskpmerdaeiqit...llnltysgdqkmsvrhlqwtewpdrgvppckltslellsai........rgsk...vpivvhcsag

GCQAGTFCALSTLHQEMIHEE-AVDIYKTVKLYAAKRPNLITSREDYYYL
  ..||  |.  . ...  .  .  . . ||    .|   | .  .| ..
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 673-751 6.4e-08 26.5 In-house 34-117 (347) alignment
Range on Protein: 673-751
Range on HMM: 34-117/347.0
DVENKLKNRYTNIVSYDSSRVSLQPL-----PGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
   .  |||  .    |..|| | |      .  .   |||| .|   | .| || ||  |  |  |||..|   |   .| | 
wekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 961-1042 7.3e-08 26.2 In-house 24-110 (332) alignment
Range on Protein: 961-1042
Range on HMM: 24-110/332.0
FSKARQSKHKNRDM----DLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETME-DFWKMLWEHNSTTIVTLTDD
. .. .   .| ||     |  ...||| ..   | | . |||...|| ... ||..| |  .  |  ||.|. |.. . |. . | 
ypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdi

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 963-1042 7.7e-08 26.3 In-house 43-117 (303) alignment
Range on Protein: 963-1042
Range on HMM: 43-117/303.0
KARQSKHKNRDMDLIPVERSRVPISGvpgvDGYINASFLQgYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDD
.  .  .||| .|.| .. |.| .|       || ||.|.    ..  |.|| | . |  |||.|. | .   .. |  |
qfvknmdknrfvdvicldhskvklsd....ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltd

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 760-913 8.4e-08 26.1 In-house 149-301 (332) alignment
Range on Protein: 760-913
Range on HMM: 149-301/332.0
KCDRYWPAKGTPERYNELEVtlELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHG-VPPYTLPVLSFIQ----RSSAANPTDAGPIIVHC
 | ..|| |.. . .  | .  .  . ..   ..|| |    ||.    ...   .|. .| |   .| | | . . |.    |||       |||.. |
icrkfwpekrskkdfpalsi..qasddhsethmktfnltvtekkq....dhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvc

SAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
..|| .   .  || .. ..  | .| .   .  |. ||   ..|   |    ..|...
atgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf

fn3 Fibronectin type III domain 364-444 9e-08 25.4 Pfam-A 2-85 (85) alignment
Range on Protein: 364-444
Range on HMM: 2-85/85.0
PPHGVIQVGKNPRSLQVFWNKPNLQNGKILFYYAYIRRRDSFF-WSRFKTSKQH--HLFLGLEVFTDYIIKVSASTNAGEGPNS
.|...   . ...||.. |..|. ..|.|  |    |  ..   | .|......  . . ||.  |.| ..| | ..||||| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_PTPDC1_pd Subfamily PTPDC1 809-908 9.1e-08 26.7 In-house 80-170 (182) alignment
Range on Protein: 809-908
Range on HMM: 80-170/182.0
ERRVYHFHYtDWPDHGVPPYTLpVLSFIQRSSAAnpTDAGPIIVHCSAGVGRTGTYIVIDTMLK-QMQAEEKVnvfgflKRIRTQRNYLVQTEEQYVFIH
|. .|.. .  |.|.||.. .  .|  ..  . |   . | . ||| || ||||  |    . . ...||. .      | .| .|   .|| ||  ...
eqgiyvynf.gwkDygvasler.iLdivkvvafa..lqegkvavhChaGlGrtGvliacylvyakrltaekai......klvrskrpksiqtreqvelvk

D
.
e

subfamily_PTEN_pd Subfamily PTEN 809-906 3e-07 25.6 In-house 79-172 (184) alignment
Range on Protein: 809-906
Range on HMM: 79-172/184.0
ERRVYHFHYTdwpDHGVPPYTLpVLSFIQRSSAANPTD-AGPIIVHCSAGVGRTGTYIVIdTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFI
. || ..  .   ||  ||  | . ....  ..   .|    ..||| || ||||. ||   .||... |.. ..  . ...||. .  |.   |  ..
dgrvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 980-1209 3.4e-07 24.7 In-house 31-251 (290) alignment
Range on Protein: 980-1209
Range on HMM: 31-251/290.0
ERSRVPISG--VPGVDGYINASFLQgYRRQNEYIVTQYPSAET-------MEDFWKMLWEHNSTTIVTLTDDQKEDEP-------IYWPTNVDEPLTLGA
| .||.. |     .|.|| |.... .    . |.|| | ...       .|.|| |  . ... .| | . .....         | |..|.| |... 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

LTITLwkrntlispssqgKFLGQSSQGTHTPLVIQnkeFDDDDQLNVRQYHCSYWPDCCSPLHTaFDLIYAVQKrnefLErsNKETvgPITVHDRSGGCQ
||.               |   .  .  .  ||..   |||. .. |  .  . | ..  . .|   |. ..||    ..  ...|  |. ||.  |  .
ltvkC.............kskekeddvetRelvvk...fddeeeftvtHsllkgWnklnvqedt.ktllsliqk....vk..askt..pvivHcvdGiSr

AGTFCALSTLHQEMI-HEEAVDIYKTVKLYAAKRPNLITSREDYYYL
  .. |.    | ..  ...| . . .|    .| ..||| ... . 
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 815-915 5.5e-07 22.5 In-house 210-310 (346) alignment
Range on Protein: 815-915
Range on HMM: 210-310/346.0
FHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
 |.. |     || |||.. .| .  . .   .  . |    | ||. ..|     ..|..   . |..  .| |. ||   |..  ||  |. ......
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

R
 
a

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1149-1212 1.6e-06 21.8 In-house 317-380 (392) alignment
Range on Protein: 1149-1212
Range on HMM: 317-380/392.0
TVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
    | ||  ||  ..| ||.      .. . ..|||..|||.  | | . . . |.| .... 
kefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydv

subfamily_CDC14_pd Subfamily CDC14 834-895 2.3e-06 21.7 In-house 250-315 (328) alignment
Range on Protein: 834-895
Range on HMM: 250-315/328.0
SFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDtMLKQMQAEEkVNVFGFLKRIRT------QRNY
. ...  ..  .  | |.||| ||.||||| |    ..|. .     .. ..|. .|       |...
aivkkfleiaekaeGaiavhCkaGLGrtGtLiacy.lmkhyrfta.aeaiawlricrPGsvigpqqkf

Syndecan Syndecan domain 574-610 4.8e-06 14.3 Pfam-A 16-44 (64) alignment
Range on Protein: 574-610
Range on HMM: 16-44/64.0
AGRVVGVVFALFVLLglilgvlgFVILRMRKKDRMSF
|| |||..|| ...|        |.. ||||||  |.
aggvvgllfAvllvl........flvyRmrKKDEGSY

PTPc_motif_SM00404 824-890 5.8e-06 21.3 In-house 61-121 (140) alignment
Range on Protein: 824-890
Range on HMM: 61-121/140.0
GVPPYTLPVLSFIQRSsaanPTDAGPIIVHCSAGVGRTGTYIVIDTML-KQMQAEEKVNVFgflKRIR
 . .|   ||.||...     .. | ..||| ||| |..| |.   |  .|....| ....   |. |
klskyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefv...kerR

PTEN_1 813-863 6.2e-06 21.1 In-house 95-146 (196) alignment
Range on Protein: 813-863
Range on HMM: 95-146/196.0
YHFHYTDWPDHGVPPYTLP---VLSFIQRSSAANPtdAGPIIVHCSAGVGRTGT
. ..  ...|||.|.       . |||.  .....   . ..||| ||.||.||
veylhfpieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGt

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 945-1014 6.3e-06 20.3 In-house 26-94 (95) alignment
Range on Protein: 945-1014
Range on HMM: 26-94/95.0
DEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDgYINASFLQGYRRQNEYIVTQ
|..|. |       |    .     ||| ....| . .|| ..     | |||| |..|| |.| || .|
dnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.yinacfvdgyarkncyiaaq

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 994-1124 9.3e-06 18.7 In-house 56-155 (169) alignment
Range on Protein: 994-1124
Range on HMM: 56-155/169.0
GYINAsflqgyrrqneyivtqypsaetmedfwKMLWEHNSTTIVTLTDDqkEDEPIYWPTNVDEPLTlGALTITLWKRNTLISPSSQGKFLGQSSQGTHT
 ||||                           .|.|| |.. || | |   .|   .||   |  |   |. .  |  ..|   . . . . .  .|   
dyina...........................rmiwetnasvivvlgdt..ddknnfwpekedyqlh.pavilgewytdslyvrtdkvhantsgveglfe

-PLVIqnKEFDDDDQLNVRQYHCSYWPDCCSP
  .||  ...|||   ... .| | ||.   |
vsmvi..hsydddvteklsllhystwpqngvp