Gene SpurPTP-sf1-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP080_AA protein Get Run
SpurP080_AA_1-111 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-117 1.5e-84 278.7 In-house 276-392 (392) alignment 
Range on Protein: 1-117
Range on HMM: 276-392/392.0
TSHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
.||||||||||||||||||||.|||||.|||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeya

FVYDVNGEYLHTENYEQ
|||||..||||||.|||
fvydvireylhtekyeq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-114 3.2e-56 185.5 In-house 171-281 (315) alignment 
Range on Protein: 1-114
Range on HMM: 171-281/315.0
TSHTVTQYQFHGWPKHGSDQQLGarSLIKLIRAIKGStNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
.|.||||.||..||..|.|.|..  ||.|||...|.. | |||||.||||..|.|||||.....|..|||....|||.|..||.|||.|...||||||||
esrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

FVYDVNGEYLHTEN
|.||.  |.|.  |
fiydavledllwrn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-114 4.4e-52 171.8 In-house 171-280 (515) alignment 
Range on Protein: 2-114
Range on HMM: 171-280/515.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.||||..|..||..|....  ..||.|||...| ...  . .....||..|.|||||........|.......||.|..|...|..|...|||.|.|||
srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

VYDVNGEYLHTEN
.|..  |.|.  |
iygavledllwrn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-116 3.3e-39 129.8 In-house 176-290 (297) alignment 
Range on Protein: 2-116
Range on HMM: 176-290/297.0
SHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
 . | ||||  ||..  ...  |.||.|||  .. . ....|  .|||||.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.|
rrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykf

VYDVNGEYLHTENYE
|| .  |.| .|...
vyvavleallsedtr
subfamily_PTPRD_pd Subfamily PTPRD 2-115 4.9e-33 109.6 In-house 176-286 (564) alignment 
Range on Protein: 2-115
Range on HMM: 176-286/564.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTnSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|..|.|..|  || ||  ..  |.||..||| .. .. ....  |.||| .| ||||.|..   .. .| | . |||.|.|| ||..|   ||||| |.|
sreVrqFhFtsWPdhgvpes..atslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiF

VYDVNGEYLHTENY
....  |.|.  | 
iheailealacgnt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-113 3.2e-31 103.6 In-house 177-286 (305) alignment 
Range on Protein: 2-113
Range on HMM: 177-286/305.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.||.|||.  || ||  |.  | ||..||. .. . .. |. ..||||  | ||||||..    . .. . ..||.|. .| ||  ||. ||| ..| |
srtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvf

VYDVNGEYLHTE
..|.  |.... 
lhdaldelitcg
DSPc_SM00195 2-109 4.3e-30 100.3 In-house 157-261 (263) alignment 
Range on Protein: 2-109
Range on HMM: 157-261/263.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
...|||||...||.|| ...  ..|...|.||.| |.... .  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|
trkvtqyqyknWpdhgvpds..tksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlf

VYDVNGEY
.|..  ||
iyeailey
PTPc_SM00194 2-109 4.3e-30 100.3 In-house 157-261 (263) alignment 
Range on Protein: 2-109
Range on HMM: 157-261/263.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
...|||||...||.|| ...  ..|...|.||.| |.... .  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|
trkvtqyqyknWpdhgvpds..tksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlf

VYDVNGEY
.|..  ||
iyeailey
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-114 5.5e-30 99.5 In-house 174-284 (318) alignment 
Range on Protein: 2-114
Range on HMM: 174-284/318.0
SHTVTQYQFHGWPKHGSDQQLgaRSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
| .| ||..  || .|. ..    ||..|.| ..   .....  |.||| .| ||||||..    . .|..   ||.||||| ||  |   ||||. | |
srqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyef

VYDVNGEYLHTEN
.|||  |.|.. .
iydvllealasgd
0046845 (Phosphotyrosine protein) phosphatases II 2-111 2.3e-29 98.1 In-house 164-275 (284) alignment 
Range on Protein: 2-111
Range on HMM: 164-275/284.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNS-KKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGD---SVDIFQTVKILRADRMQFVQTEE
|.|||......|| ||  ..  ...|....|... . .. ...  |.|||  | ||||.|.... .. |. ...    ||....|| ||  |...|||.|
srtvthfhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

EYAFVYDVNGEYLH
 | |||..  ||| 
qyrfvyealleylk
0050432 (Phosphotyrosine protein) phosphatases II 2-111 3.4e-29 97.6 In-house 196-300 (308) alignment 
Range on Protein: 2-111
Range on HMM: 196-300/308.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTnskKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.|||......|| ||  ..  ...|........ |    ..  |.|||  | ||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | |
srtvthfhytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf

VYDVNGEYLH
.|..  |||.
lyralleylk
subfamily_PTPRK_pd Subfamily PTPRK 3-108 1e-28 95.1 In-house 173-275 (314) alignment 
Range on Protein: 3-108
Range on HMM: 173-275/314.0
HTVTQYQFHGWPKHgsDQQLGARSLIKLIRAIKGSTNSkKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
..| |.|| |||.|  |    |..|.||.| .| |..  ..  |.|||..||||||.|..    .  | . . ||.|..|| ||. .. .|.||| | |.
revrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

YDVNGE
|||  |
ydvile
Y_phosphatase Protein-tyrosine phosphatase 3-105 1.8e-28 94.9 Pfam-A 133-232 (235) alignment 
Range on Protein: 3-105
Range on HMM: 133-232/235.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTnSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
..|.|.....||.||  ..  ..||..|||... |. ..|. ...|||  |.||||.|.... .. |. ....||..|.|| ||. |.. ||..|.|.|.
revkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

YDV
|..
yka
Y_phosphatase Protein-tyrosine phosphatase 3-105 1.8e-28 94.9 In-house 133-232 (235) alignment 
Range on Protein: 3-105
Range on HMM: 133-232/235.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTnSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
..|.|.....||.||  ..  ..||..|||... |. ..|. ...|||  |.||||.|.... .. |. ....||..|.|| ||. |.. ||..|.|.|.
revkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

YDV
|..
yka
0051299 (Phosphotyrosine protein) phosphatases II 2-109 8.3e-28 93.1 In-house 181-285 (288) alignment 
Range on Protein: 2-109
Range on HMM: 181-285/288.0
SHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAIKGSTNsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.|||......|| ||  .   ...|....|... . . ...  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.. |||.| | |
srtvthfhytnwpdhgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf

VYDVNGEY
||..  ||
vyealley
PTPc_DSPc_SM00012 4-105 9.4e-28 91.9 In-house 1-102 (105) alignment 
Range on Protein: 4-105
Range on HMM: 1-102/105.0
TVTQYQFHGWPKHGSDQQLgaRSLIKLIRAIKGSTNSKK-EFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||  ..    |...|.||.| ..| .. . ...|||  |.||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

VYDV
.|..
lyra
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-114 1.5e-27 91.6 In-house 184-294 (298) alignment 
Range on Protein: 2-114
Range on HMM: 184-294/298.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
...| | .|  || .|  ..  |.|...|.| .. |..  .. ...|.| .| ||.| |.     . .. .  .||.||.||.||..|.. |||||.|.|
erevrqlhftsWpdkgvpen..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvf

VYDVNGEYLHTEN
.|..  |.|.. |
iyeavlealdsfn
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-114 1.8e-27 91.2 In-house 178-287 (319) alignment 
Range on Protein: 3-114
Range on HMM: 178-287/319.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 .|...|.  || |.  ..  |.||..|.. |. |.. ...  | |||  |.|||| |..    . .. |   .|.|.||. ||. |   ||..| | |.
RevkhfqyteWpdhdvPek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi

YDVNGEYLHTEN
|..  |.... .
yealleaveagd
0036941 (Phosphotyrosine protein) phosphatases II 2-111 7.3e-27 89.9 In-house 167-278 (297) alignment 
Range on Protein: 2-111
Range on HMM: 167-278/297.0
SHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAIKgsTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIA---EGDSVDIFQTVKILRADRMQFVQTEE
|.|||.....||| ||  .      ..|.|.| .    .. ..  .||||  | ||.|.|..|  .. |.    .   |||...|| ||  |.. |||.|
srtvthfhytgwpdhgvpespaslldfielvrkvl..kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

EYAFVYDVNGEYLH
 | |.|..  |.| 
qyrflyeallellk
0047943 (Phosphotyrosine protein) phosphatases II 2-110 1.1e-26 89.4 In-house 165-272 (273) alignment 
Range on Protein: 2-110
Range on HMM: 165-272/273.0
SHTVTQYQFHGWPKHGSD-QQLGARSLIKLIRAIKGSTNSKkeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
|.|||.....||| ||   .     ..|.|.| .  ...|.    ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.  |||.| | 
srtvthfhytgwpdhgvppslesllefielvrkalealpsn..gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr

FVYDVNGEYL
|.|..  |||
flyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 3-110 1.3e-26 88.3 In-house 191-296 (330) alignment 
Range on Protein: 3-110
Range on HMM: 191-296/330.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEfSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
  |.|. |..||. |   .  .. ..||....|   . . . .| ||| .|.|||| |..    ....     ||.|..|| ||. | | |||.| | |.
rlvrqfhftswPdvGvPfe..piGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

YDVNGEY-L
| |  || |
ykvlleyyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-105 1.5e-26 88.1 In-house 175-274 (288) alignment 
Range on Protein: 3-105
Range on HMM: 175-274/288.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 ..||||. .|| ||  ..  .. |..|.| .| . ...    |.|||  | ||||.| ..   | .. | | .|.. ||. ||  |...|||.. | |.
leitqyqylaWpdhgvPes..kapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

YDV
|.|
yev
subfamily_PTPRB_pd Subfamily PTPRB 2-110 1.1e-25 85.3 In-house 178-285 (293) alignment 
Range on Protein: 2-110
Range on HMM: 178-285/293.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGST-NSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
...|.||.|  || ||  ..  ...|....|... .. .....  |.||| .| ||||.| .  . . .| | | |||| .|  || .|...||||..| 
erkvrqyhftsWpdhgvPek..tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYi

FVYDVNGEYL
|....  ..|
fihqcvldll
0040438 (Phosphotyrosine protein) phosphatases II 2-110 2e-25 85.2 In-house 171-276 (317) alignment 
Range on Protein: 2-110
Range on HMM: 171-276/317.0
SHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAIKGSTNsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.|||.....||| ||  .    ..|.....|.. . . ...  .||||  | ||||.|..|  .. |. ..  ||....|| ||. |.. |||.| | |
srtvthfhytgWpdhgvpp..spdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrf

VYDVNGEYL
.||.  |||
lydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 2-110 7.5e-25 83.4 In-house 182-289 (297) alignment 
Range on Protein: 2-110
Range on HMM: 182-289/297.0
SHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAIKGSTnsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
|.|||..|..||| ||  .      ....|.| .  ..  .|.  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | 
srtvthfqytgwpdhgvppslellleflelvrealael..pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyr

FVYDVNGEYL
|.||.  |.|
flydallell
0043336 (Phosphotyrosine protein) phosphatases II 2-109 1.3e-24 82.5 In-house 172-276 (278) alignment 
Range on Protein: 2-109
Range on HMM: 172-276/278.0
SHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAIKGSTNsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.|||.|...||| ||        .|.....|..   . ...  .||||  | ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | |
srtvthyhylgwpdhgvpe..slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

VYDVNGEY
.|..  ||
lyealley
0045450 (Phosphotyrosine protein) phosphatases II 2-109 1.9e-24 82.4 In-house 194-303 (307) alignment 
Range on Protein: 2-109
Range on HMM: 194-303/307.0
SHTVTQYQFHGWPKHGSDQQ-LGARSLIKLIRAIKGSTnsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEE
|.|||.....||| ||  .    . ..|...|.. ...  .|.  .||||  | ||||.|..|  .. |. ..     ||....|| ||. |.. ||..|
srtvthfhytgwpdhgvppsfeelldfieevrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe

EYAFVYDVNGEY
 | |.|..  |.
qyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3-112 2.5e-24 80.8 In-house 137-244 (250) alignment 
Range on Protein: 3-112
Range on HMM: 137-244/250.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 .| |..|  ||  |  ..  |.. ..|.. .. | .  ..  ..|.| .| ||.| |..    . .. .   ||.|. .|.||.||.. |...| | ||
rivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfv

YDVNGEYLHT
| .  ..| .
yeiilkalds
0045098 (Phosphotyrosine protein) phosphatases II 2-111 3.5e-24 81.1 In-house 153-273 (278) alignment 
Range on Protein: 2-111
Range on HMM: 153-273/278.0
SHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAIKGSTN------------SKKEFSILVHCLSGAGRTGVFCTAMECIAQIaeGDSVDIFQTVKILRADR
|..||......|| ||.  .   .|...|.. |.   .              ..  .||||  | ||||... |. .. ..  .. ||....|| ||  |
srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqR

MQ-FVQTEEEYAFVYDVNGEYLH
..  ||..| | |.|..  |.|.
pglavqnleqyrflyefllelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 3-112 5.4e-24 79.6 In-house 178-285 (290) alignment 
Range on Protein: 3-112
Range on HMM: 178-285/290.0
HTVTQYQFHGWPKHGSDQQlGARSLIKLIRAIKgSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
..|||||.  |...|. ..  . .|. . . .|     . . ||.|||  . ||..|||.|.  | .      .|.|| .| .|  ... |||...| ..
qsvtqyqitnwdstgkvtn.pqtillvieemyk.tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgi

YDVNGEYLHT
...  .||..
fqivltylds
subfamily_PTPRG_pd Subfamily PTPRG 3-114 8.4e-24 78.7 In-house 183-291 (563) alignment 
Range on Protein: 3-114
Range on HMM: 183-291/563.0
HTVTQYQFHGWPKHGSDQQlgarSLIKLIRAIKGSTNSKKE-FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
..|.||..  || ||. ..    || .|| ..| |.  |.|   |.||| .|.||||...     . || . ..|..|...| .|| |   |||||.| |
klvrqyhytkWPdhgvPeh....slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif

VYDVNGEYLHTEN
..|.  | . ...
lhdalleaiaske
0042113 (Phosphotyrosine protein) phosphatases II 2-109 1.4e-23 79.0 In-house 137-242 (245) alignment 
Range on Protein: 2-109
Range on HMM: 137-242/245.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|..|..|....|| ||       ..|........   .....  .||||  | ||||.|..|  .. |. .   |.....|| ||  |.. |||.. | |
srevihyhylpwpdhgvpdl..lellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrf

VYDVNGEY
.|..  |.
lyeallel
0040439 (Phosphotyrosine protein) phosphatases II 2-109 3.5e-23 77.9 In-house 139-245 (249) alignment 
Range on Protein: 2-109
Range on HMM: 139-245/249.0
SHTVTQYQFHGWPKHGSD-QQLGARSLIKLIRAIKGSTnsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
|.||...|...|| ||       . ..|...| .  ..  .|.  .||||  | ||||.|..|  .. |. .   ||....|| ||  |.. ||..| | 
srtvlhiqytdwpdhgvppsfedlldfieavrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

FVYDVNGEY
|.|..  |.
flyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-113 5.2e-23 76.7 In-house 178-291 (325) alignment 
Range on Protein: 3-113
Range on HMM: 178-291/325.0
HTVTQYQFHGWPKHGSDQQLGA-RSLIKLIRAIKG--STNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEY
 .| |.|. .|.  | ...  .  |...|. |..    .|.|    ||||| .| |||||| .    .|.. |  .||||. || ||.|| . |.| ..|
rsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqy

AFVYDVNGEYLHTE
 ..|.   |.. . 
iliyealveaymsg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2-113 9.6e-23 75.5 In-house 151-267 (270) alignment 
Range on Protein: 2-113
Range on HMM: 151-267/270.0
SHTVTQYQFHGWPKHGSDQQLG----ARSLIKLIRAIKGSTNSKKE-FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTE
.. .. .... || ||  .. .    ...|.|..||.. |......   .||||  | ||||.. .   ..  . |  .||. . .. || |||..||. 
errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhp

EEYAFVYDVNGEYLHTE
|.|.|.| .  || .. 
eqyeflykavveyaerr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 3-114 1e-22 75.4 In-house 173-282 (287) alignment 
Range on Protein: 3-114
Range on HMM: 173-282/287.0
HTVTQYQFHGWPKHGSDQQLgARSLIKLIRAIKGSTNSkKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
..|.|||.  |...|  ..  . .|. . . .|    .  . ||.|||  . ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| |.
qqvkqyqitnWdstgkvtep.qtillvieemyktqrkr.gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfi

YDVNGEYLHTEN
.|.  |||.. .
ndivleyldsfe
subfamily_PTPN12_pd Subfamily PTPN12 2-109 1.4e-22 75.0 In-house 169-276 (290) alignment 
Range on Protein: 2-109
Range on HMM: 169-276/290.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNsKKEFSILVHCLSGAGRTGVFCTA---MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEE
|..|.|.... || ||  ..  | ||..||....   . ...  ..||| .| ||||. ..     | . .    ...|.|. |  || .|   |||.| 
srkvyqfhYtaWPDhgvPss..aksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq

YAFVYDVNGEY
| .||    |.
yelvykavael
subfamily_CG7180_pd Subfamily CG7180 4-110 1.5e-22 74.6 In-house 181-290 (296) alignment 
Range on Protein: 4-110
Range on HMM: 181-290/296.0
TVTQYQFHGWPKHgSDQQLGARSLIKLIRAIKGSTNSK----KEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEY
.|...|.  |. .     | . .||.|.| ..   .      .|  ..|..  ||.|.||....  .. .. . . ||.|. || || .| | |.. |||
ivklfqlteWele.dkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeY

AFVYDVNGEYL
 ..|||  |..
kyiYdvlleav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 5-105 2.6e-22 74.0 In-house 164-261 (283) alignment 
Range on Protein: 5-105
Range on HMM: 164-261/283.0
VTQYQFHGWPKHGsdQQLGARSLIKLIRAIKGSTNSKKeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
.. ||. .| . |  .|    ||.|. . |   |.|||   |.||| .| |||.||..|.  . ..     ||.|..|||.| .||  ||| . | .|..
lahyqvidWleyg..eqaiinslvkfnkvislqteskk.gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhe

V
.
l
subfamily_Ptp69D_pd Subfamily Ptp69D 3-109 5.1e-22 73.4 In-house 182-285 (307) alignment 
Range on Protein: 3-109
Range on HMM: 182-285/307.0
HTVTQYQFHGWPkhGSDQQLGARSLIKLIRAIKGSTNSKkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
. |.||.. ||.   |     ||.|.|||. ..   . . .  |.|||  |.||.|.| .    . |. . |.||||.||| || .|  .||  | | |.
rkvvqyhytgWk..DskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl

YDVNGEY
|    .|
yralldy
0051429 (Phosphotyrosine protein) phosphatases II 2-110 5.8e-22 74.1 In-house 119-225 (272) alignment 
Range on Protein: 2-110
Range on HMM: 119-225/272.0
SHTVTQYQFHGWPKHGSDQQLgARSLIKLIRAikgstnskkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVD--------IFQTVKILRADRMQFV
...|.......|| ||  |.   ..|..|...         .  .|||| .| .|||... .  ..... . . ||        ....|. ||| |...|
arevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgav

QTEEEYAFVYDVNGEYL
|||| |.|.|..  |.|
qteeqylflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 2-106 5.9e-22 73.9 In-house 132-238 (243) alignment 
Range on Protein: 2-106
Range on HMM: 132-238/243.0
SHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAIKGST----NSKKEFSILVHCLSGAGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRMQ-FVQT
...|..|....|| ||  .      .... .|..  ..    . ...  .||||  | ||||....|  .. ..    .||....|| ||. |..  |||
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqt

EEEYAFVYDVN
.. | |.|.. 
psqyrflyeal
subfamily_PTPN6_pd Subfamily PTPN6 2-114 2.1e-21 71.2 In-house 185-301 (306) alignment 
Range on Protein: 2-114
Range on HMM: 185-301/306.0
SHTVTQYQFHGWPKHGSDQQLGAR-SLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQI---AEGDSVDIFQTVKILRADRMQFVQTEE
...| ||.|. || ||  .. ||  .... ... . ....... .|.||| .| |||| |      . .|        .|| ..||..|. | ..||||.
erevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteq

EYAFVYDVNGEYLHTEN
 | ||| .  .|..|..
qykfvykaikkyietkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-111 3.9e-21 70.4 In-house 162-269 (274) alignment 
Range on Protein: 4-111
Range on HMM: 162-269/274.0
TVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEF--SILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
.|. | .  || | | ..  |..|..|.. .. | .....   ...||| .| ||||.| ..  .. |. |   ||....|  || ||   |||.| | .
svkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyel

VYDVNGEYLH
.. .  .||.
ihralclylk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-112 4.9e-21 70.1 In-house 170-278 (281) alignment 
Range on Protein: 3-112
Range on HMM: 170-278/281.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAF
 .|.| ..  || ||  ..  .. |..  ....  |..|.. ....|| .| ||||.. .    . ... |  ..|. ..|. || .|. .|||   |.|
reveqlaytaWPdhGvPat..tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyef

VYDVNGEYLHT
|| .  ..|. 
vykavldaldk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3-106 8.7e-21 69.1 In-house 175-275 (315) alignment 
Range on Protein: 3-106
Range on HMM: 175-275/315.0
HTVTQYQFHGWPKHGSdqQLGARSLIKLIRAIKGSTNSKKeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
..| |...  ||. |      . .|..||| .|   ...   .|.||| .| |||| |.|    . |.   . .|... .. .|. |.. ||. |.| |.
revvqlhytswpdmgv..pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfi

YDVN
||. 
ydal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4-105 1.5e-20 68.8 In-house 186-286 (319) alignment 
Range on Protein: 4-105
Range on HMM: 186-286/319.0
TVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAIKGSTNSKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 .||. | |||..|  .       |.| .| ..   | ..  .|.||| .|.|||||. .    . .. | . ||....|. || .| ..||   .| |.
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra..nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

YDV
|  
ysa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4-105 2.3e-20 68.3 In-house 150-250 (284) alignment 
Range on Protein: 4-105
Range on HMM: 150-250/284.0
TVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAIKGSTNSKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
...|. | |||..|  .       |.| .| ..   | ..  .|.||| .|.|||||. .    . .. | . ||....|. || .| ..||   .| |.
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhra..nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

YDV
|  
ysa
0036282 (Phosphotyrosine protein) phosphatases II 3-105 2.7e-20 68.2 In-house 67-165 (174) alignment 
Range on Protein: 3-105
Range on HMM: 67-165/174.0
HTVTQYQFHGWPKHGSDQQLGarsLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAeGDSVDIFQTVKILRADRMQFVQTEEEYAFV
... ||.. .|| ||         |........   .....  .||||  | ||||... |. .. ..   . ||....|. ||  |.. |||.. | |.
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YDV
|..
yyf
subfamily_PTPN13_pd Subfamily PTPN13 2-110 3.2e-20 67.6 In-house 165-269 (273) alignment 
Range on Protein: 2-110
Range on HMM: 165-269/273.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNskKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|. |.. .|  || ||  ..  | .|..... ..   .  ..  |.||| .| ||.|.. |    .  |.   ..|. ..|. ||  |   |||.. | |
srevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyif

VYDVNGEYL
|| .  | |
vykailevl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2-108 7.8e-20 65.6 In-house 88-192 (440) alignment 
Range on Protein: 2-108
Range on HMM: 88-192/440.0
SHTVTQYQFHGWPKHGSDQQLGarSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.|. ||...||| .|  .  |   ..|.|. .. | .   .  .|||| .|||||||  .    . .    | .|||  .. .| .| |.||| |.|||
srtlkqyhyqgwpdkgvpkfag..pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

VYDVNGE
|...  |
vheavle
subfamily_PTPN9_pd Subfamily PTPN9 3-109 1.1e-19 65.6 In-house 173-289 (297) alignment 
Range on Protein: 3-109
Range on HMM: 173-289/297.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAI---KGST---------NSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRM
 .|| .|| .|| .|  ..  | ||.......   ....            ..  |.||| .| |||| |.|   |.... | . ||...||| ||. | 
rkvthfqflsWPdyGvPss..aaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqra

QFVQTEEEYAFVYDVNGEY
  .||.| |.| |    ||
fsiqtpeqyefcylavley
0041856 (Phosphotyrosine protein) phosphatases II 3-114 1.6e-19 65.6 In-house 77-175 (182) alignment 
Range on Protein: 3-114
Range on HMM: 77-175/182.0
HTVTQYQFHGWPKHGSDQqlgARSLIKLIRAIKGstnskKEFSILVHCLSGAGRTGVFCTAMECIAQiaegdSVDIFQTVKILRADRMQFVQTEEEYAFV
....||....|| ||       ..|...|....      ..  .||||  | ||||... |  .. .     .|.....|| .|  |.. |.|.. | |.
rlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyffl

YDVNGEYLHTEN
...  |.|.  .
qlallellllkk
subfamily_PTPN14_pd Subfamily PTPN14 3-111 8.9e-19 62.6 In-house 183-297 (300) alignment 
Range on Protein: 3-111
Range on HMM: 183-297/300.0
HTVTQYQFHGWPKHGSDQQL-GARSLIKLIRAIKGSTNSKKE-----FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTE
 ||   |.  ||.||  . . |  | .. .....  |||..|       .||||. |.|||||  ..   || .  ....|| .....||  || .||| 
rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl

EEYAFVYDVNGEYLH
  | |||.|  .||.
aqYkfvYkvlikylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-114 1.1e-18 62.0 In-house 187-297 (301) alignment 
Range on Protein: 2-114
Range on HMM: 187-297/301.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|..|.|.|   ||..|  ..   |  .. |  .   ...     ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | .
swdvlqlqvtdWpqdGvvre..prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyts

VYDVNGEYLHTEN
.|||  .||. ..
iydvidmylqlns
0043147 (Phosphotyrosine protein) phosphatases II 3-108 5e-18 60.9 In-house 63-159 (172) alignment 
Range on Protein: 3-108
Range on HMM: 63-159/172.0
HTVTQYQFHGWPKHGSDqqlGARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFV
... ||....|| ||      .. |..... |.   . ...  .||||  | ||||... |  ..       .......|. .|. |.. ||... | |.
rlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

YDVNGE
|. .  
yyfekl
subfamily_PTPN23_pd Subfamily PTPN23 3-111 6.9e-18 59.4 In-house 171-281 (288) alignment 
Range on Protein: 3-111
Range on HMM: 171-281/288.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKG---STNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEE
..|.  |.. ||..|  .     .|.... ...    ... | .  ..|||..| ||||||.  .  .... .|. . || | |. ||..|   ||..|.
ksvshlqltsWpelGvPas..PetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeq

YAFVYDVNGEYLH
. |.|..  |. .
lkfsyeavleaar
subfamily_PTPN3_pd Subfamily PTPN3 2-104 1.8e-17 58.2 In-house 170-269 (280) alignment 
Range on Protein: 2-104
Range on HMM: 170-269/280.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSkKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
.....| |.  || ||  ..  . ....... ..   .. ||  ..||| .| |||||. .   ..| | . ..| . . |. .|  |. .|||.. | |
erkilqlqylaWpdhgvPdd..sadflefvervrklrsg.keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykf

VYD
| .
vCe
subfamily_PTPRN_pd Subfamily PTPRN 3-106 2.7e-17 57.4 In-house 187-288 (297) alignment 
Range on Protein: 3-106
Range on HMM: 187-288/297.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSkKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
 ||||. |  ||..|   .  |.||... | .  |    .  .|.||| .|||||||..     ..... |   .||  |.. || .| ..|.|.... |
rtvtqfhflswpeegvPas..aksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef

VYDVN
.. . 
altav
0046846 (Phosphotyrosine protein) phosphatases II 7-109 5.7e-17 57.5 In-house 78-172 (176) alignment 
Range on Protein: 7-109
Range on HMM: 78-172/176.0
QYQFHGWPKHGSDQQlgaRSLIKLIRAIKGSTNSKkeFSILVHCLSGAGRTGVFCTAMeciaQIAEGDSVDIFQTVKILRADRM-QFVQTEEEYAFVYDV
||....|| ||  .    . |..|...|.   ...    .||||  | ||||... |      .  .  ........ .|. |. . |||.| | |.|..
qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef

NGEY
  ..
elll
0048076 (Phosphotyrosine protein) phosphatases II 3-108 1.2e-16 56.1 In-house 45-141 (145) alignment 
Range on Protein: 3-108
Range on HMM: 45-141/145.0
HTVTQYQFHGWPKHGSDQQLgaRSLIKLIRAIKGSTNSKkeFSILVHCLSGAGRTGVFCTAMECIAqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFV
....||.. .|| ||  . |  . |......|.   ...    .||||  | ||||... |. ..       .|....... .|. |...|.... . |.
rlgiqylylpwpDhgvpdll..ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

YDVNGE
|..  |
yefele
0051082 (Phosphotyrosine protein) phosphatases II 3-104 3.1e-16 54.8 In-house 58-147 (151) alignment 
Range on Protein: 3-104
Range on HMM: 58-147/151.0
HTVTQYQFHGWPKHGSDQQ-LGARSLIKLIRAikgstnsKKEFSILVHCLSGAGRTGVFCTAMECIAQiaegdsVDIFQTVKILRADRMQFVQTEEEYAF
..|.......|| .| ..    ......|...       ||.  .|||| .| ||||... .. .. .      |....... .|. |. .||..... |
ievlhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

VYD
.. 
qlf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-103 3.3e-16 54.2 In-house 137-233 (239) alignment 
Range on Protein: 4-103
Range on HMM: 137-233/239.0
TVTQYQFHGWPKHGSDQQlgARSLIKLIRAI-KGSTNSKKEFsiLVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 | ||.|  || .|  |   | ... | | | | |    . .  ..|| .| |||| |      . |  .  .||||. || .| || ..||| |.| |.
yvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

Y
.
h
0048179 (Phosphotyrosine protein) phosphatases II 4-106 3.3e-16 54.8 In-house 48-141 (144) alignment 
Range on Protein: 4-106
Range on HMM: 48-141/144.0
TVTQYQFHGWPKHGSDQQ-LGARSLIKLIRAIKGstnskKEFSILVHCLSGAGRTGVFCTAMECIaqiAEGdsVDIFQTVKILRADRMQFVQTEEEYAFV
...||.. .|| ||  .     ......|...       ..  .||||  | ||||....|  ..    .|  ........ .|. |.. |.... . |.
egiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgavpnpgqlrfL

YDVN
.. .
leye
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 5-104 3.5e-16 54.1 In-house 135-233 (237) alignment 
Range on Protein: 5-104
Range on HMM: 135-233/237.0
VTQYQFHGWPKHGSDQQLGArsLIKLIR-AIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVY
. ||||  ||..|  ||  |  |... .  |. |    .    ..|| .| ||||.|      . |  |   |||.. |. .  ||   .||...| |..
ihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih

D
.
q
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4-103 3.6e-16 54.1 In-house 138-234 (239) alignment 
Range on Protein: 4-103
Range on HMM: 138-234/239.0
TVTQYQFHGWPKHGSDQQlgARSLIKLIRAI-KGSTNSKKEFsiLVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 | ||.|  || .|  |   | ... | | | | |    . .  ..|| .| |||| |      . |  .  .||||. || .| || ..||| |.| |.
yvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

Y
.
h
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-105 8.4e-16 52.4 In-house 174-274 (439) alignment 
Range on Protein: 3-105
Range on HMM: 174-274/439.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
.|| |...  ||..    |  |  .....|||. . ....   ..||| .| ||||   .   .. |.   . |||   ||.|| .| |.||.  .| |.
rtvlqfhyiawpdknvpaq..ashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfi

YDV
|. 
yna
0049260 (Phosphotyrosine protein) phosphatases II 7-106 9.4e-16 53.3 In-house 56-146 (152) alignment 
Range on Protein: 7-106
Range on HMM: 56-146/152.0
QYQFHGWPKHGSDQQLGARSLIKLIRAIKgstNSKKEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVN
||... || ||  .       . |.  .    . .|.  .||||  | ||||... |  ..        |.....|. .|. |.. |.... . |.|...
qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflyefe
subfamily_CG42327_pd Subfamily CG42327 18-109 5.8e-15 49.8 In-house 221-314 (319) alignment 
Range on Protein: 18-109
Range on HMM: 221-314/319.0
SDQQLGARSLIKLIRAIKGSTNSK-KEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVNGEY
|  . |. |  ..   |   .  . .   . |||  |.||||.  ..   | .. |   |||| |.|  .| || . |.| | |.|.| |  ||
skaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
0049772 (Phosphotyrosine protein) phosphatases II 5-110 2.4e-14 49.3 In-house 180-280 (314) alignment 
Range on Protein: 5-110
Range on HMM: 180-280/314.0
VTQYQFHGWPKHGSDQQLGARSLIKLIRAIkgstnsKKEFSILVHCLSGAGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRM-----QFVQTEEEY
. .|  . .| .. .     ......|..       .|.  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... |.|
gikylripvpDgsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqy

AFVYDVNGEYL
 |....  |||
efilealleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2-115 2.7e-14 47.9 In-house 175-285 (307) alignment 
Range on Protein: 2-115
Range on HMM: 175-285/307.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTNskkefSILVHCLSGAGRTGVFCTAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYA
| |....|.. || .|  |     . | |. |... ||      ..||| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| 
srtiqhlqwenwpdrgvpqi..nltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl

FVYDVNGEYL---HTENY
... |  ||.   . | |
ylhrvlleyflelykety
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 48-110 2.7e-14 47.3 In-house 2-64 (69) alignment 
Range on Protein: 48-110
Range on HMM: 2-64/69.0
VHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVNGEYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| |..|   | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 47-110 3.2e-14 47.1 In-house 2-65 (69) alignment 
Range on Protein: 47-110
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVNGEYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || |..|   | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
0044763 (Phosphotyrosine protein) phosphatases II 7-110 1.3e-13 46.5 In-house 77-171 (178) alignment 
Range on Protein: 7-110
Range on HMM: 77-171/178.0
QYQFHGWPKHGSDQ-QLGARSLIKLIRAIKgstnSKKEFSILVHCLSGAGRTGVFCTAMECIAQiaegdSVDIFQTVKILRADRMqFVQTEEEYAFVYDV
||.. ..| ||  .     . ....|...     ..|.  .||||  | ||.|... |  .. .     ...... .. .|. |. .|.... . ..|..
qylhipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef

NGEYL
  ..|
elrll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2-109 4e-13 44.0 In-house 155-258 (267) alignment 
Range on Protein: 2-109
Range on HMM: 155-258/267.0
SHTVTQYQFHGWPKHGSDQQLgARSLIKLIrAIKGstNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
.| || | .. |     ..    . |. .. | .     . .  ..|.|  | ||.| | ..   . .. . . .|||. .. .|  |. .|.| |.| .
ahnvtlyyykkwnintnnkpy.lkplfgil.aknq..lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiy

VYDVNGEY
....  ||
ihellaey
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 9-113 7.1e-13 43.2 In-house 173-273 (285) alignment 
Range on Protein: 9-113
Range on HMM: 173-273/285.0
QFHGWPKHGSDQQlgARSLIKLIRAIKGStNsKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVNGE
|   || . . ..  || .|.| . .|   |  ||  | ||| .| |||  |     .  .| |   ..... |. .|| |.| ||.  .. |.| |  |
qvpwwpdqlaped..arpmielykwvkkv.n.pkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme

YLHTE
|.  |
yfige
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-112 1.6e-12 41.8 In-house 168-279 (287) alignment 
Range on Protein: 3-112
Range on HMM: 168-279/287.0
HTVTQYQFHGWPKHGSDQQ-LG-ARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
. | |...  ||...     .| .|  ..  . |. . ....   ..||.  |.||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . 
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlr

FVYDVNGEYLHT
..|.    | .|
llyealvtyykt
subfamily_PTPN1_pd Subfamily PTPN1 2-103 7.4e-12 39.6 In-house 161-264 (290) alignment 
Range on Protein: 2-103
Range on HMM: 161-264/290.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGSTN-SKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEE
....... .  ||  |  .     ...|..  .. |   |..    ..|| .| ||.| || .  |...| . |    ||| ...  ||  |. ..|| .
treilhfhyttwpdfgvpes..paaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad

EYAFVY
   | |
qlrfsy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 8-109 9e-12 39.0 In-house 186-284 (302) alignment 
Range on Protein: 8-109
Range on HMM: 186-284/302.0
YQFHGWPKHGSDQQLGarSLIKLIRAIkGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVNG
| .. |...   .. .  .||| .  .    ..| . ....    |||| |.| |..  . .. .|. . | ..|| .|..| . |.. . |...| .  
yvltnWkqkkvpvkya..eliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

EY
 |
ly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-105 9.8e-12 39.1 In-house 182-278 (290) alignment 
Range on Protein: 2-105
Range on HMM: 182-278/290.0
SHTVTQYQFHGWPKHGSdqqlgARSLIKLIRAIKGStnSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
.| .  ..   || .       | | . |.| ..     |    . ||| .| |||| | .   ..  . .| ..|. ..|. ||  |.. || . .|  
ehklkhlkikswpdksv.....alstlallrtlril..rkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla

VYDV
. ..
lvei
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 7-116 1.1e-11 39.4 In-house 175-277 (288) alignment 
Range on Protein: 7-116
Range on HMM: 175-277/288.0
QYQFHGWPKHGSDQQLgaRSLIKLIRAIkgsTNSKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVN
.  .. |...|  ..    | ..|.  .    . .|   |.||.  |.|||| .   .  . ..   | . | . .. ||..|.. .|||  | .|. . 
ilhlleWdddgvPeny..lsplrllevl...kslqk..PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

GEYLHTENYE
 |.|    |.
leelllkkyk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 41-105 1.4e-11 38.8 In-house 226-290 (297) alignment 
Range on Protein: 41-105
Range on HMM: 226-290/297.0
KKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 ..  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. ..||.
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2-99 1.6e-11 38.5 In-house 180-270 (301) alignment 
Range on Protein: 2-99
Range on HMM: 180-270/301.0
SHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAIKGSTNskkefSILVHCLSGAGRTGVFCtAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEY
..||| ||.. |...|  .  .   | .|.  .| | .      |.||| .| ||.  |  . |..|.  | |  ... ...| || .| . |||..  
trtvthyqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsql
subfamily_ptpA1_pd Subfamily ptpA1 4-67 3e-11 37.7 In-house 187-253 (418) alignment 
Range on Protein: 4-67
Range on HMM: 187-253/418.0
TVTQYQFHGWPKHG-SDQQLGARSLIKLIRAIK--GSTNSKKEFSILVHCLSGAGRTGVFCTAMECI
 .||||. ||| |   |.    | |.. |   .     .| ..  |.||| .| |||| ||||.  .
ditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4-111 8.9e-11 36.0 In-house 189-290 (305) alignment 
Range on Protein: 4-111
Range on HMM: 189-290/305.0
TVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGStnskkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFV
.| . |.  ||  |        . ..|. ||.||     .  |.||| .| ||||   .    . .|||  ..  . . || || .|   .|.. .| |.
svrhlqwtewpdrgvppc..kltslellsairgs.....kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi

YDVNGEYLH
. |  .|. 
hrvmlnyfl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2-103 1.4e-10 35.8 In-house 157-252 (290) alignment 
Range on Protein: 2-103
Range on HMM: 157-252/290.0
SHTVTQYQFHGWPKHgsDQQLGARSLIKLIRAIKgstnsKKEFSILVHCLSGAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYA
 .||| ....|| |     |   ..|..||. .|     ...  ..|||  |  |  .. .       ||   .|| . . .| ||  | . .....|.|
eftvtHsllkgWnkl..nvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalela

FVY
|| 
fvd
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3-111 1.5e-10 35.3 In-house 186-288 (305) alignment 
Range on Protein: 3-111
Range on HMM: 186-288/305.0
HTVTQYQFHGWPKHGSDQqlGARSLIKLIRAIKGStnsKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQ-TVKILRADRMQFVQTEEEYAF
. ||.| .  ||  |        ....|.   . |   |    | ||| .| ||||        . |. .|. ..  .  .. .| .| . .||...| |
rkvthyhwidwpdrgvpa..adlailellekarps...kg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

VYDVNGEYLH
|..|  .|..
vhqvilnyfr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 5-113 3e-10 34.3 In-house 178-279 (312) alignment 
Range on Protein: 5-113
Range on HMM: 178-279/312.0
VTQYQFHGWPKHGSDQQLGarSLIKLIRAIKgstNSKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
. .||.  || ||  .     .  .|. |.|   . ||   .. || .| |||| ..     || .      .. ..  .|| || . |..  .| ..  
lnhyqwaswpdhgmpdscd..talrllsavk...kdkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalr

VNGEYLHTE
.  |.|...
cvleflysk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 3-101 3.1e-10 34.0 In-house 188-279 (302) alignment 
Range on Protein: 3-101
Range on HMM: 188-279/302.0
HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKgstNSKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
.||   .| .||.||. ..  | . .....  .     ||  ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   .
ktvdilafsawpdhGapke..aytaldilkfce...sykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 40-108 4.4e-10 33.8 In-house 259-342 (350) alignment 
Range on Protein: 40-108
Range on HMM: 259-342/350.0
SKKEFSILVHCLSGAGRTGVFCTAMECIA------QIAEG---------DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVNGE
...  .||||| .| ||||...|    .       .. .              |...|..||  |.. ||. . . |.|.    
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4-105 3.1e-09 31.3 In-house 96-199 (199) alignment 
Range on Protein: 4-105
Range on HMM: 96-199/199.0
TVTQYQFHGWPKHGSDQQLGARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAF
 ...|||  | .. . .      ..   | .    . .|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

VYDV
.|.|
iyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4-105 3.1e-09 31.3 In-house 95-198 (198) alignment 
Range on Protein: 4-105
Range on HMM: 95-198/198.0
TVTQYQFHGWPKHGSDQQLGARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAF
 ...|||  | .. . .      ..   | .    . .|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

VYDV
.|.|
iyqv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2-96 9e-09 29.8 In-house 115-207 (255) alignment 
Range on Protein: 2-96
Range on HMM: 115-207/255.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKgstNSKkefSILVHCLSGAGRTGVFCTAmECIAQ-----IAEGD--SVDIFQTVKILRADRMQFVQ
 |||. |...||... . ..  || . .......   .||   |..||| .| ||.  |  | | . |     . . .   .|  . .. ||  | . ..
thtvkhysykGWieknaPel..areilnilkvvr...dsk...svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraih

TE
| 
tP
subfamily_hpo-7_pd Subfamily hpo-7 2-91 3.4e-08 27.7 In-house 121-208 (263) alignment 
Range on Protein: 2-91
Range on HMM: 121-208/263.0
SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAIKGStnsKkefSILVHCLSGAGRTGVFCTAmECIAQ-----IAEGD--SVDIFQTVKILRADRMQ
 |||..|.. ||...   ..  ||. ...... ..|   |   |. ||| .| ||.  |  | | . |     . . .   .|  . .. ||  | .
thtvkhysykgWiekndpel..areilnilkvarns...k...slvvhcstGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 40-109 9.3e-08 25.8 In-house 262-343 (349) alignment 
Range on Protein: 40-109
Range on HMM: 262-343/349.0
SKKEFSILVHCLSGAGRTGVFCTAMECIA--QIAEGDSVD----------IFQTVKILRADRMQFVQTEEEYAFVYDVNGEY
...  ..|||| .| |||||..|    ..  .  . .|.           |. .| .||  |.. ||   .. ..|.   .|
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_PTPDC1_pd Subfamily PTPDC1 22-105 1.4e-07 26.1 In-house 93-171 (182) alignment 
Range on Protein: 22-105
Range on HMM: 93-171/182.0
LGARSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDsvdifQTVKILRADRMQFVQTEEEYAFVYDV
 |..|| ...  .|  . . .|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .| . 
ygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvkef
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 6-110 2.2e-07 23.8 In-house 207-309 (346) alignment 
Range on Protein: 6-110
Range on HMM: 207-309/346.0
TQYQFHGWPKHgSDQQLGARSLIKLIRAIKgSTNSKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 | . |   ||  .|   .  .||.|  .. | .  ..  . |  | |.||.  |  |.  | |. .|   .|.. .| .. .|   |..  .|| .| .
cqvhhhapwkh.lqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

NGEYL
  .|.
vfdyi
0038934 (Phosphotyrosine protein) phosphatases II 25-62 1.7e-06 23.3 In-house 97-134 (194) alignment 
Range on Protein: 25-62
Range on HMM: 97-134/194.0
RSLIKLIRAIKGSTNSKKEFSILVHCLSGAGRTGVFCT
  | . .....  .| ...  ..|||  | ||||... 
eillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
PTPc_motif_SM00404 8-67 2.3e-06 22.5 In-house 47-103 (140) alignment 
Range on Protein: 8-67
Range on HMM: 47-103/140.0
YQFHGWPKHGSDQQLGARSLIKLIRAIKGStnSKKEFSILVHCLSGAGRTGVFCTAmECI
.|.   | . ....  .. | |... |. .   ||. ..||||  |  |.. ...| ...
fqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliia.Ylm
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 9-110 5.6e-06 20.2 In-house 177-279 (303) alignment 
Range on Protein: 9-110
Range on HMM: 177-279/303.0
QFHGWPkHGSDQQLGARSLIKLIRAIKGSTNSKKEF-SILVHCLSGAGRTGVFCTAM-ECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVN
... || |.|    |.  ..| |  ..       .    .   ||| ||.| |.      ..  .|  |.|. . .. .|  |.. ||   ....|| . 
hykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll

GEYL
 |..
aehv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 46-105 7.5e-06 19.7 In-house 226-285 (310) alignment 
Range on Protein: 46-105
Range on HMM: 226-285/310.0
ILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .||| .| .|..| ..    | .. .|. ||. . .  |. .|.. .||| .| ..  |
cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv