Gene SpurPTP-sf1-5 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP082_AA protein Get Run
SpurP082_AA_326-559 phosphatase_domain Get Run
SpurP082_AA_571-845 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 449-735 1.6e-181 598.9 In-house 167-453 (515) alignment 
Range on Protein: 449-735
Range on HMM: 167-453/515.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
||||.|||||||||||||||||||||||||.||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||..||||||||
kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqya

FIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYM
|||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||| ||.|||||||||||.|||||||| |||||||| |
fiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqm

KGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKA
||.||||.|||||||||||||||||.. ||||||||||| |.|||||||||. .| .||||||| ||||||||.| |||.|||||| 
kgihctfmttqmplpttvsdfwsmvlnnkpstivmlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 323-598 1.9e-178 587.8 In-house 1-276 (392) alignment 
Range on Protein: 323-598
Range on HMM: 1-276/392.0
RQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIAS
||||||||||||.|.|||||||..|||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||||.||||||||||.||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTR
.|||||||.|||||||||||||||||||||.|||.||||||||||.||||||||||||||||||.||.|||||||||||||||||||||||||||||.||
lddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktr

MVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKS
||||||||||||.|||.||||.|||||||||||||||||||||||||||||||||..|.||..|||..|||..||.
mvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefrslka
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 601-849 6.4e-124 407.9 In-house 29-282 (315) alignment 
Range on Protein: 601-849
Range on HMM: 29-282/315.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-S
|||.....|..|...|..||||.|.|||...||.|    || |.|||||||.|.|..  ..|..|.||...|.|||.||.. |..||||...| ..|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPN--DDSAKFGSYSVSILSTSSDGDVTTRQLkVTRNSKASHTVTQYQFHGWPKHGSDQQPGarSLMKLIRAVKSStNKKKEFSILVHCLSGSGRT
|.||||.   ||..|||..|..||...|.| ..|.| |||.|..|.||||.||..||..|.|.| .  ||.|||..||.. |.|||||.||||..| |||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENY
||.....|..|||....|||.|..||.|||.|...||||||||| |....|.|.  | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 711-851 8.7e-95 312.4 In-house 252-392 (392) alignment 
Range on Protein: 711-851
Range on HMM: 252-392/392.0
VSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSV
...|||||||||...|||..|..||||||||||||||||||||||.|||||.|||||||.|||.|||||||||||||.||||||||||||||||||||||
lqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsv

DIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYEQ
|||||||||||||||||||||||||.|.|||||||||.|||
difqtvkilradrmqfvqteeeyafvydvireylhtekyeq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 589-850 2e-89 294.6 In-house 23-290 (297) alignment 
Range on Protein: 589-850
Range on HMM: 23-290/297.0
MTKEFQTLKSLCPdpPASQTRSGRTPDNQ---PKNRYGNNLPLERNRVILDSS----DHDYINASYMKGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTI
.  .. . . ||.  |....... . ...   .|.|| | || ...||.| .     | ||.|||..||..  .|||||| ..|| ||| ||.| ..|||
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSI
|||||. ..||.||.||... ...||. || .||.|.      |.|.||... || . | ||||  ||..  ...  |.||.|||  |. . ....|  .
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYE
|||||.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.| |... |.| .|...
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 449-596 4.3e-86 283.6 In-house 168-315 (315) alignment 
Range on Protein: 449-596
Range on HMM: 168-315/315.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
|....||||||.|||||||||.|.||||||.|||||||.|. ...|..||||||||||||||||.|||..| ||.|||||||.|.|.|||..|||.|.||
kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

FIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTL
|||.|||||||||||||.|.||||||||||.|.||.|||||||||.||
fiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefetl
0051299 (Phosphotyrosine protein) phosphatases II 343-556 2.2e-77 255.7 In-house 24-284 (288) alignment 
Range on Protein: 343-556
Range on HMM: 24-284/288.0
LFSGEFHDLPGPD-IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMV
..  ||..|.     .....|... ||.||||..|||||. |||| |.|....||| |||||. .......|| |||   ...|||||||..||..| |.
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvml

TKLKEGD----------------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLI
||| | .                                              ... .||||.||.| ||| ||| ....||.|...|.  . .  .| .
tklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvv

IHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.||||||||||..| .| .. . .....|||...|  .|..||.|||| ||| |.| |.||
VHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 556-846 3.4e-77 255.1 In-house 10-301 (308) alignment 
Range on Protein: 556-846
Range on HMM: 10-301/308.0
EDLLWRNTLIPVVHFTDHLQDLHS-SGDGRGRSKMTKEFQTLKSLCPdppASQTRSGRTPDNQPKNRYGNNLPLERNRVILdSSDHDYINASYMKGV---
| ||.|.| |.|.... ...||.    .  ..... .||..| |..|     ...... |.|..|||| . ||....||.| ....|||||||..|    
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssk

-HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPND---DSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFH
  ..|| || |||.|| ||| ||.. . ..||||..  . . . ||||||..   .| ..| ..| .||. ...|.|.|.|..|  ... |.|||.....
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhyt

GWPKHGSDQQpgARSLMKLIRAVKSSTnkkKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
.|| ||  ..  ...|......|..|    ..  |.|||  | ||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | | |... |||.
nWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

T
.
l
0050432 (Phosphotyrosine protein) phosphatases II 323-562 3.9e-76 251.6 In-house 23-303 (308) alignment 
Range on Protein: 323-562
Range on HMM: 23-303/308.0
RQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQ-TVAQKEINLKKNRYKNILPYDSARVKLevidDiPHSDYFNASYIPSF--DNDKAYIASQGPN
  ...| ..  ..|.   . |.. ||..|.   .... .||... | .|||||.|||||. ||||    | ..||| ||||.. .  ......|| ||| 
slklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl

IASMDDFWRMVWQENVTTIAMVTKLKEGDK---------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTS
  ...|||||||..||..| |.||| | ..                                             ....||||.||.| ||| ||| ...
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspe

SLLKFIKEVKADHGQftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRN
.||.|...|.  ...  .| ..||||||||||..| .| .. . .....||||. |  .|..||.|||| ||| |.| |.|| |... 
illdflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 339-595 5.7e-76 251.1 In-house 16-313 (317) alignment 
Range on Protein: 339-595
Range on HMM: 16-313/317.0
RHsALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
 .  ... ||.||.  .... .||... | .||||..|||||. |||| ... ...||| ||||.. ..  ...|| |||   ...|||||||...||.|
df.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

AMVTKLKEGD------------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLII
 |.|.|.| .                                          .... ||||.||.| ||| |||.....||.|...|..   .  .|...
vmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlV

HCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQT
||||||||||..| .. .. . .... |||.. |  .|..|| .||| ||| |.| |.|| |....||.|. ..  .|. |.    . . . ..||...
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelkl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 325-449 4.2e-75 247.8 In-house 1-125 (515) alignment 
Range on Protein: 325-449
Range on HMM: 1-125/515.0
PIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMD
|.|.||||||.. ||| .||| ||||||||.||||||||.||| |||||||||||||.|||||||.| ||||||||||||||||||||||||||| ||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLKEGDK
||||.|.||||||||||||||||||
dfWrlvlqenvttiamvtklkegdk
0051299 (Phosphotyrosine protein) phosphatases II 562-844 5.7e-75 247.7 In-house 2-286 (288) alignment 
Range on Protein: 562-844
Range on HMM: 2-286/288.0
NTLIPVVHFTDHLQDLHssgdGRGRSKMTKEFQTLKSLCPDppaSQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKG--VHCTF
.| |.| ....... |.     .| ... .||..| ||.||    ...... | |..|||| . ||....||.| .    ...|||||||..|    ..|
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

ITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-----NSKASHTVTQYQFHGWPK
| || |||.||.||| ||.. . ..||||..    . . ||||||...| ..| ..| .||. ...|.|.|.|.||.      .. |.|||......|| 
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

HGSDQqpGARSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
||  .   ...|....|.|... . ...  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.. |||.| | | ||.. |||
hgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 353-564 4.7e-74 244.6 In-house 11-280 (284) alignment 
Range on Protein: 353-564
Range on HMM: 11-280/284.0
GPD---IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDD-IPHSDYFNASYIPSF-----DNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
      ... .||... ||.|||||.|||||. |||| ..|. ...|||.||||.. .     .. |..|| |||   ...|||||||..||..| |.|.
sltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlte

LKEGDK--------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG--QFTHPLIIH
| | ..                                            .. .||||.||.|.||| ||| ....||.|...|.  .      .| ..|
lvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVH

CSAGVGRTGVVISIDSVVAHAKTTR---MVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTL
|||||||||..| .| .  . ....   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_PTPRD_pd Subfamily PTPRD 603-850 6.8e-74 244.5 In-house 35-287 (564) alignment 
Range on Protein: 603-850
Range on HMM: 35-287/564.0
PPASQTRSGRTPDNQPKNRYGNNLPLERNRVILD----SSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCA
.. ..... . | |..|||| | .. ...||.|      .. ||||||...| .   ..| || ||..|..||| ||.. . ||||||.    ..|  |.
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

QYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKV-TRNSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTnKKKEFSILVHCLSGSGRTGVF
.|||.......|.. |.. ..    |.. |..|. . .|. |..|.|..|  || ||  ...  .||..||| |.... ....  |.||| .| ||||.|
kYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYE
..   .. .| | . |||.|.|| ||..|   ||||| |.| .|.| |.|.  | |
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
DSPc_SM00195 589-844 2.7e-73 241.9 In-house 2-262 (263) alignment 
Range on Protein: 589-844
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIV
. .||..|..  ..    .|.... . |. |||| | || ...||.|....    .|||||.|.||     ..| ||.|||.||.||| ||.. | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKGQ-SDKSCAQYWPND--DSAKFGSYSVSILSTSSDG-DVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKkE
||..  .   . |..|||..  .. .||..|| . .. ..  ....|.|..| .  . ...|||||...||.|| ....  .|...|.||||.|.... .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdst..ksvlellravkksksts.s

FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.| ||.| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 589-844 2.7e-73 241.9 In-house 2-262 (263) alignment 
Range on Protein: 589-844
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIV
. .||..|..  ..    .|.... . |. |||| | || ...||.|....    .|||||.|.||     ..| ||.|||.||.||| ||.. | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKGQ-SDKSCAQYWPND--DSAKFGSYSVSILSTSSDG-DVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKkE
||..  .   . |..|||..  .. .||..|| . .. ..  ....|.|..| .  . ...|||||...||.|| ....  .|...|.||||.|.... .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdst..ksvlellravkksksts.s

FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.| ||.| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 589-846 2.8e-73 242.1 In-house 2-276 (284) alignment 
Range on Protein: 589-846
Range on HMM: 2-276/284.0
MTKEFQTLKSLCPDPPaSQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGV-------HCTFITTQMPLPTTVSDFWSMVFDF
. .||..| || ...   ... .. | |. |||| . ||....||.|.|     .|.|||||||..|        ...|| ||.|||.|| ||| ||.. 
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTIVMLNDKGQSDK-SCAQYWPNDD-SAKFGSYSVSILSTSSDGDVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSST
. ..||||..  . ..  ||||||... . ..| ..| .||.  ..|.|.| |..|..  .. |.|||......|| ||  ..  ...|....|.|... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrell

NK-KKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
.. ...  |.|||  | ||||.|.... .. |. ...    ||....|| ||  |...|||.| | | ||.. ||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 563-848 7.3e-73 240.4 In-house 3-294 (298) alignment 
Range on Protein: 563-848
Range on HMM: 3-294/298.0
TLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVHC--TFI
| | . ... .|| | .     . .....|||.|.|   . .. ... .|.|.|. |||| . ..|.  ||.| .     . ||||||.... .   .||
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafi

TTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQ
.|| ||..||.||| || . . .|||||..  ..||  . .|||.. ....|. .||.||. . .|...|.|||.... . ...| | .|  || .|  .
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe

QpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
.  |.|...|.| |. |... .. ...|.| .| ||.| |.     . .. .  .||.||.||.||..|.. |||||.|.| ||.. |.|.. |
n..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0036941 (Phosphotyrosine protein) phosphatases II 347-569 9.1e-72 237.2 In-house 18-288 (297) alignment 
Range on Protein: 347-569
Range on HMM: 18-288/297.0
EFHDL-PGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLeviDDiPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLK
||..| |   ... .||... ||.|||||.|||||. ||||   || ..|||.||||.. .| ....|| |||   ...|||||||..|||.| |.|.| 
efeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelv

EGDK----------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FTHPLIIH
| ..                                              ... ||||.||.| ||| ||| ...|||.||..|.  . .    .| ..|
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

CSAGVGRTGVVISIDSVVAHAK---TTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVH
|||||||.|..| .| ..   .   ... ||....|  .|..||..||| ||| |.| |.|| |....| .|.. 
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 335-556 1.6e-71 236.3 In-house 5-270 (273) alignment 
Range on Protein: 335-556
Range on HMM: 5-270/273.0
IENNRHSALFSGEFHDLPGP-DIYPQTVAQKEINLKKNRYKNILPYDSARVKLevidDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQE
.|.  ...|.  ||..|.   .... .||... |..|||||.|||||. ||||    . ..||| ||||.. ..  ...|| |||   ...|||||||..
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NVTTIAMVTKLKEGDK---------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG
||..| |.|.| | ..                                              ...||||.||.|.||| ||| ...|||.||..|.  . 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

Q--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.    .| ..||||||||||..| .| .. . .....|||.. |  .|..|| |||| ||| |.| |.||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 585-848 4.5e-71 234.9 In-house 11-281 (297) alignment 
Range on Protein: 585-848
Range on HMM: 11-281/297.0
GRSKMTKEFQTLkslCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIV
..... |||..|   .|  .   .. .. |.|..|||| . ||....||.||....|||||||..| .   .|| || |||.|| ||| ||.. . ..||
flalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKGQSDK-SCAQYWPND--DSAKFGSYSVSILSTSS--DGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNKK-
||..  . ..  ||||||..  .| ..| ..|  ||...  ..|.|.|.|.||  ... |.|||.....||| ||  .   ..||...|..|..  ..  
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllp

KEFSILVHCLSGSGRTGVFCTAMECIAQIA---EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
..  .||||  | ||.|.|..|  .. |.    .   |||...|| ||  |.. |||.| | | ||.. |.| . .
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0047943 (Phosphotyrosine protein) phosphatases II 584-844 1.1e-70 233.6 In-house 9-272 (273) alignment 
Range on Protein: 584-844
Range on HMM: 9-272/273.0
RGRSKMTKEFQTLKSLCPdppASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTI
 |.... .||..|.||.|      .. .. |.|. |||| . ||....||.|.....|||||||..|  .  .|| ||.||| || ||| ||.. . ..|
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLNDKGQSDK-SCAQYWPNDD---SAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNKK-
|||..  . ..  ||||||..    | ..| ..| .||. ...|.|.|.|..|. ... |.|||.....||| ||  .     ||...|..|..  ..  
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkalealp

KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.  |||.| | | ||.. |||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 339-556 1.6e-70 233.1 In-house 17-275 (278) alignment 
Range on Protein: 339-556
Range on HMM: 17-275/278.0
RHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
   .|.. ||..|.  .......|... | .|||||.|||||. ||||....  ..||| ||||.. ..  ...||.|||.  ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLKEGD-----------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIH
 |.|.|.| .                                         . . .||||..|.. ||| ||| ..|.||.|.|.|.       .|...|
vmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVH

CSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
|||||||||..| .. .. ...... ||... |  .|..|| .|||..|| |.| |.||
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 584-844 4.4e-70 231.8 In-house 29-289 (297) alignment 
Range on Protein: 584-844
Range on HMM: 29-289/297.0
RGRSKMTKEFQTLKSLCPDppasqTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGVHC---TFITTQMPLPTTVSDFWSMVFD
 ..... .||..|.|| ||     .. .. | |..|||| . ||....||.| .      |.|||||||..| ..   .|| || ||| || ||| ||..
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

FKPSTIVMLNDKGQSDKSCAQYWPNDDSaKFGSYSVSILSTSSDGDVTTRQLKVTRnSKASHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKSSTNKK
 . ..||||..    .. ||||||.. . ..| ..|  |..  ....|.|.|.||. .. |.|||..|..||| ||    | ...|......|..  .. 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgv..ppslellleflelvrealael

-KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 |.  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | | |....|.|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 324-449 7.5e-70 230.2 In-house 1-126 (315) alignment 
Range on Protein: 324-449
Range on HMM: 1-126/315.0
QPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASM
|||||||||||...|||.|||| ||||||.||||.|.||...|| ||||||||||.||||||||||||.|.|||.|||||.|.|.||||||||||. ||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLKEGDK
|||||||.||.||||.||||..||||
ddfwrmvlqekvttivmvtkkqegdk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 565-850 1.8e-69 229.2 In-house 2-286 (318) alignment 
Range on Protein: 565-850
Range on HMM: 2-286/318.0
IPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSlCPDPpASQTRSgRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVH--CTFITT
|.| .. .|.. |..     |. ....|.. |.  ...  .....|  .| |. |||| | |. .. || |.      . |||||.|. | .   ..| .
isvedleshvrrlre....sGelllseeyerlsr.seet.vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-SKASHTVTQYQFHGWPKHGSDQQP
| ||| |..||| ||.. . ..|||| . . .. . ...|||...| ..|.  | . .. . .| . |..||||. ...| .| ||..  || .|. ...
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

gaRSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYE
   ||..|.| |..  .|...  |.||| .| ||||||..    . .|..   ||.||||| ||  |   ||||. | | |.|. |.|.. . |
..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
0045450 (Phosphotyrosine protein) phosphatases II 350-556 4.6e-69 228.8 In-house 35-302 (307) alignment 
Range on Protein: 350-556
Range on HMM: 35-302/307.0
DLP---GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYI--------PSFDNDKAYIASQGPNIASMDDFWRMVWQENVTT
.|.    ..... ..|... | .|||||.|||||. |||| ..|.  ..|||.||||.        ...|.....|| |||   ...|||||.|...||.
kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtv

IAMVTKLKEG--------------------------------------------DKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FT
| |.|.|.|                                             |. .  ||||.||.|.||| |||.....||.||.||.. ...    
ivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg

HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.| ..||||||||||..| .. .  . ... .   ||... |  .|..|| .||..||| |.| |.||
gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 568-845 6e-69 228.1 In-house 3-277 (317) alignment 
Range on Protein: 568-845
Range on HMM: 3-277/317.0
VHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQMP
... ..|.||. |.      .. .||..| || .|     .. .. |.|..|||| . ||....||.| . .    .|||||||..|     .|| || |
ldlllalldllksdf....talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgP

LPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGAR
|| || ||| ||.. . ..||||..  .  .. ||||||.... ..| ..| .||.  ....| |.|.|.  ... |.|||.....||| ||  .    .
lpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spd

SLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
.| ....||... . ...  .||||  | ||||.|..|  .. |. ..  ||....|| ||. |.. |||.| | | |....||| 
llldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0039614 (Phosphotyrosine protein) phosphatases II 333-563 6.4e-69 228.0 In-house 23-294 (297) alignment 
Range on Protein: 333-563
Range on HMM: 23-294/297.0
AFIENNRHSALFSGEFHDLPGPDIyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMV
 ..|.   . |.  || .|.   . ....|... | .|||||.|||||. |||| ..|.  ..||| ||||.. .|  ....||.|||.  ...||||||
lllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WQENVTTIAMVTKLKEGDK--------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--F
|...||.| |.|||.| ..                                      ..  ||||.|..| ||| ||| ....||.|...|.  . .   
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNT
 .| ..||||||||||..| .. .. . .... |||.. |  .|..|| .||| .|| |.| |.|| |....|
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 606-847 2.7e-67 222.1 In-house 36-286 (305) alignment 
Range on Protein: 606-847
Range on HMM: 36-286/305.0
SQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS----DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLN-DKGQSDKSCAQYW
...  |..  |. |||. .. .|. .|.||  .    |.|||||||..| .   ..|..| ||..||.||| .....|.||||||   . . .. | |||
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PNDDSA--KFGSYSVSILSTSSDGDVTTRQLKVTR--NSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVF
|.  .   .||..|| . |...  | ..|.||..   ..| |.||.|||.  || ||  |.  | ||..||. |. . .| |. ..||||  | ||||||
pesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
..    . .. . ..||.|. .| ||  ||. ||| ..| | .... |.... 
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 582-842 6.3e-67 220.6 In-house 16-277 (288) alignment 
Range on Protein: 582-842
Range on HMM: 16-277/288.0
DGRGRSKMTKEFQTLKSLcpdPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFD
. |.|. ...|...| .|      ...  || . |..|||| | ||.. .|| |.     .. |||||||..| .   ..|.|| ||. || ||| .|..
sarnrtgfseeynsLaal...ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

FKPSTIVMLNDK-GQSDKSCAQYWPNDDS-AKFGSYSVSILSTSSDGDVTTRQLKVTrNSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSsTN
 | ||||||..   . .. | .|||..|   ..||  | ....   .|...|.| .   .|   ..||||. .|| ||  .   .. |..|.| ||  .|
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPe..skapllellrqvkv.an

KKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
...   |.|||  | ||||.| ..   | .. | | .|.. ||. ||  |...|||.. | | |||. .
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 611-846 8.4e-67 220.0 In-house 4-244 (250) alignment 
Range on Protein: 611-846
Range on HMM: 4-244/250.0
GRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQYWPNDDSA
.. |.|. |||| . ..|.  ||.| ...     ||||||...| .   .||.|| ||..|. ||| ||.. | .|||||..  .|.| . |||| . . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

KFGSYSVSILSTSSDGDVTTRQLKVTRNSKASH-TVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQ
|.|.  ||.||.   .|.|.|.||.....||.. .| |..|  ||  |  ..  |.. ..|.. |..| .. ..  ..|.| .| ||.| |..    . .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
. .   ||.|. .|.||.||.. |...| | | ||.| ..| .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
Y_phosphatase Protein-tyrosine phosphatase 616-840 2.5e-66 218.9 Pfam-A 1-233 (235) alignment 
Range on Protein: 616-840
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLERNRVIL-DSSD-HDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWP--NDDSAKFGS
|. |||| . || ...|| | .|.. .|||||.|.||   . .|| ||.||. |..||| ||.. | ..||||..  .. .. ||||||  ...| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSIL-STS-SDGDVTTRQLKVTRNSKA--SHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTnKKKEFSILVHCLSGSGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||  ..  ..||..|||.|..|. ..|. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
 ....||..|.|| ||. |.. ||..|.|.| |..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 616-840 2.5e-66 218.9 In-house 1-233 (235) alignment 
Range on Protein: 616-840
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLERNRVIL-DSSD-HDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWP--NDDSAKFGS
|. |||| . || ...|| | .|.. .|||||.|.||   . .|| ||.||. |..||| ||.. | ..||||..  .. .. ||||||  ...| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSIL-STS-SDGDVTTRQLKVTRNSKA--SHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTnKKKEFSILVHCLSGSGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||  ..  ..||..|||.|..|. ..|. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
 ....||..|.|| ||. |.. ||..|.|.| |..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0043336 (Phosphotyrosine protein) phosphatases II 567-844 1.1e-65 217.2 In-house 4-277 (278) alignment 
Range on Protein: 567-844
Range on HMM: 4-277/278.0
VVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPdppaSQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQM
| .. ..|..|. ..  .    . .||..| |  .      .. .. |.|..|||| . ||....||.|.. .    .|||||||..|     .|| || 
vkdllkallelllnlktl....lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqg

PLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPnDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGA
||| || ||| ||.. . .|||||..    . . |||||| ..| ..| ..|  |.. ...|.|.|.|.||.  .. |.|||.|...||| ||       
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..sl

RSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 .|.....||..  . ...  .||||  | ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | | ||...|||
sllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 358-556 7.1e-65 214.4 In-house 2-244 (249) alignment 
Range on Protein: 358-556
Range on HMM: 2-244/249.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD---------
. .||... |..||||..|||||. ||||..... ..||| |||||. ..  ...|| |||   ...|||||.|....|.| |.|.|.| .         
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

---------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVISIDS
                                 . .. |||.....| ||| |||.....||.||..|.  . .    .|...||||||||||..| .. 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.. . .... ||... |  .|..|| .||..||| |.| |.||
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 585-844 9.8e-65 214.6 In-house 25-304 (307) alignment 
Range on Protein: 585-844
Range on HMM: 25-304/307.0
GRSKMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKG----------VHCTFITTQMPLPTTVSDF
..... |||..|.|.....    ..... | |..|||| . ||....||.| |     .|.|||||||..           .  .|| || ||| || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSMVFDFKPSTIVMLNDKGQSDKS-CAQYWPNDDSA-KFGSYSVSILSTSSDGDVTTRQLKVTR--NSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLI
| |... . ..||||..    ..  ||||||....   .| . |  ||.. ....| |.|.||.   .. |.|||.....||| ||  .     .| ..|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp..sfeelldfi

RAVKSSTNKK-KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
..|..  ..  |.  .||||  | ||||.|..|  .. |. ..     ||....|| ||. |.. ||..| | | ||...|.|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 562-848 6.5e-64 211.0 In-house 2-287 (319) alignment 
Range on Protein: 562-848
Range on HMM: 2-287/319.0
NTLIPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVH--CTF
.| |.| .. ..|. |.|     |  .. |||..||   .|    ...|  ...|..|||| | |. .| ||.|    .. . ||||||.. | .    |
dteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekf

ITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS--HTVTQYQFHGWPKHGS
| || || .|..||| ||.. . |..|||..  .     . .|||. .  ..| . | ...     |.  |.||. ..|      .|...|.  || |. 
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv

DQQpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 ..  |.||..|.. .. |..|...  | |||  |.|||| |..    . .. |   .|.|.||. ||. |   ||..| | | ||...|.... .
Pek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPRD_pd Subfamily PTPRD 451-636 8.5e-64 211.1 In-house 174-358 (564) alignment 
Range on Protein: 451-636
Range on HMM: 174-358/564.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. |.|.|||||.|||.|||... |||..|..|.| . . ..|...||||||||||. | ||...  .|. ..||....|...|..|..||||.|||.||
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFi

YGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDpPASQTRSGRTPDNQPKNRYGNNLPLERNRVILD
. |.|| |   || ... ....||| |..  .. . ... .||| |..  .. ....  ..  | |. |||. | |.||..||.|.
heailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakei.eleefavatkpknkkknrfsnilalescrvvls
subfamily_PTPRB_pd Subfamily PTPRB 565-848 1.1e-63 210.0 In-house 7-289 (293) alignment 
Range on Protein: 565-848
Range on HMM: 7-289/293.0
IPVVHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDPPasqTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITT
| . .|..|......  |     ....|...||..  |     . . ... |. |||| | || . .|| |    |.|. |||||.|..| ..   ||.|
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqa...vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPND-DSAKFGSYSVSILSTSSDGDVTTRQLKVTRnSKASHTVTQYQFHGWPKHGSDQQp
| |||.|| ||| ||.. | |.|||| .     |  | .|||.| ..  .|. .|.......  | ..|.||... .|....|.||.|  || ||  .. 
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPek.

gARSLMKLIRAVKSST-NKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 ...|....|.|.... .....  |.||| .| ||||.| .  . . .| | | |||| .|  || .|...||||..| | .... ..|....
.tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0045098 (Phosphotyrosine protein) phosphatases II 601-845 9.9e-63 207.4 In-house 18-273 (278) alignment 
Range on Protein: 601-845
Range on HMM: 18-273/278.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVIldssdhDYINASYMKGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWP
. .. |.   .  ..|..|||| . ||....||.      |||||||..| . .|| || |||.||.||| |... . ..||||..    . . ||||||
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

NDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-----NSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSSTN------------KKKEFSILV
...|  .| ..| .||..  .|.|.| |.||      ..  |..||......|| ||.  .|  .|. .|.. ...  .              ..  .||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCLSGSGRTGVFCTAMECIAQIaeGDSVDIFQTVKILRADRMQ-FVQTEEEYAFTYEVIREYLH
||  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | | ||...|.|.
HCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 599-848 5.2e-62 204.8 In-house 31-292 (325) alignment 
Range on Protein: 599-848
Range on HMM: 31-292/325.0
L-CPDPPASQTrSGRTPDNQPKNRYGNNLPLERNRVILD----SSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD
|  .| . ...     |.|. |||. | ..|...||.|     ... |||||||..      .|...|.||..|. |.| .|.|.. | .|.||   . .
llpsddgiakk.vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk

KSCAQYWPND--DSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKA-SHTVTQYQFHGWPKHGSDQQPGA-RSLMKLIRAVKSS--TNKKKEFSILVHCL
..||.|||..  .| .||.  |.. .     |   |.|.| . .|  . .| |.|. .|.  | ...| .  |...|. ||.    .| |    ||||| 
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

SGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
.| |||||| .    .|.. |  .||||. || ||.|| . |.| ..| . || . |.. . |
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
0042113 (Phosphotyrosine protein) phosphatases II 360-556 7e-62 204.3 In-house 2-241 (245) alignment 
Range on Protein: 360-556
Range on HMM: 2-241/245.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD-----------
.||... | .||||..|||||. |||| ...  ..||| ||||.. ..  . .||.|||   . .|||||.|....||| |.|.. | .           
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

-------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLIIHCSAGVGRTGVVISIDSVVA
                               . | .|.|...|.. ||| ||| ....||.|...|.        .|...||||||||||..| .. .. 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

HAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
...... |.... |  .|..|| .|||..|| |.| |.||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 612-842 3.5e-61 201.8 In-house 39-275 (314) alignment 
Range on Protein: 612-842
Range on HMM: 39-275/314.0
RTPDNQPKNRYGNNLPLERNRVILDSSDHD----YINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPNDDSA
.  .|. |||.|. |. .| ||.| . | |    ||||... . .    || || ||. || ||| .|.| . ..||||..  . .   | .|||.| . 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

kFGSYSVSILSTSSDGDVTTRQLKVTR---NSKASHTVTQYQFHGWPKHgsDQQPGARSLMKLIRAVKSSTNKkKEFSILVHCLSGSGRTGVFCTAMECI
 .|   | ...|. . .. .| ..|..   . .. ..| |.|| |||.|  |    |..|.||.| ||.|... ..  |.|||..|.||||.|..    .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
  | . . ||.|..|| ||. .. .|.||| | | |.|| |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0045098 (Phosphotyrosine protein) phosphatases II 348-560 5.9e-61 201.6 In-house 14-274 (278) alignment 
Range on Protein: 348-560
Range on HMM: 14-274/278.0
FHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKleviddiphsDYFNASYIPSFdnDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEG
.. |. ....  |.|... ||.|||||.|||||. |||          || |||||...  .|..|| |||    ..|||||.|....|.| |.|.|.|.
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

D----------------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHT--SSLLKFIKEVKADHGQ----------
.                                              ...  |.||..|.. ||| ||| ..  .|.|........ . .          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---FTHPLIIHCSAGVGRTGVVISIDSVVAHAktTRMVDVFNFVTNIRQKRPF-MVQTQEQYAFIYGAVLEDLLW
     .| ..||||||||||... .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 564-846 8.3e-61 200.4 In-house 1-285 (290) alignment 
Range on Protein: 564-846
Range on HMM: 1-285/290.0
LIPVVHFTDHLQdlhsSGDGRGRSKMTKEFQTLKSlcpDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILD--SSD----HDYINASYMKG--VHCTF
|||| .|.....     |  .|.... ..|..|.|        ..  | |..|...||. | .. . ||..|   |..    ..||||.|.||   .  .
lipvdkfgefva....nghakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy

ITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDK-GQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSK--ASHTVTQYQFHGWPKHGS
| || |.. |. |||... . | . |||| .   .  . | ||||. |....| .|. .|. ..  . ..|.|.|. ...  |...|||||.  |...|.
iatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgk

DQQPgaRSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
 ..|   . . .|. .     |. . ||.|||  . ||..|||.|.  | .      .|.|| .| .|  ... |||...| . .... .||..
vtnp..qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRG_pd Subfamily PTPRG 565-850 1.5e-60 200.0 In-house 1-293 (563) alignment 
Range on Protein: 565-850
Range on HMM: 1-293/563.0
IPVVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGVH--CTFIT
.|| .|. |. .||..|| .    ...||. |.| . .    .. . . |.|. |||| | .. .| || | .     ...|||||.|..| .    ||.
vpvkefakhvaslhadgdig....fseefealqsetisk.dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-----NSK--ASHTVTQYQFHGWPK
|| ||..|. ||| |... . ..|||. . . .  . | .|||.|.| ..|. .| . ..      |.|.|..       ...    ..|.||..  || 
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGSDQQpgarSLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
||. ..    ||..|| ..|||. .|.|   |.||| .| ||||...     . || . ..|..|...| .|| |   |||||.| | .... | . ...
hgvPeh....slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

YE
 |
te
0040439 (Phosphotyrosine protein) phosphatases II 610-844 1.2e-59 197.3 In-house 5-246 (249) alignment 
Range on Protein: 610-844
Range on HMM: 5-246/249.0
SGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDD
 .. | |..|||| . ||....||.| .     ..|||||||..|     .|| || ||| ||.||| |... . ..||||..  .   . ||||||...
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPkhGSDQQPGARSLMKLIRAVKSSTNKK-KEFSILVHCLSGSGRTGVFCTAMEC
| ..| ..|  ||. . .|.|.|.|..|.   . |.||...|...||    .  |   .|...|.||..  ..  |.  .||||  | ||||.|..|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
. |. .   ||....|| ||  |.. ||..| | | ||...|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 611-844 2e-59 196.3 In-house 4-243 (245) alignment 
Range on Protein: 611-844
Range on HMM: 4-243/245.0
GRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDS
.. | |..|||| . ||....||.| . .    .|||||||..|     .|| || ||| || ||| |... . .|||||..    . . ||||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

AKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPkhgSDQQPG-ARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECI
 ..| ..|  ||. ...|.|.|.|.||.  .. |..|..|....||    .. |   ..| .....|..  .....  .||||  | ||||.|..|  ..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp...dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 |. .   |.....|| ||  |.. |||.. | | ||...|.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 607-845 1.9e-58 192.9 In-house 49-297 (330) alignment 
Range on Protein: 607-845
Range on HMM: 49-297/330.0
QTRSGRTPDNQPKNRYGNNLPLERNRVILDSS----DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWP
        .|. |||. | || . .||||       . ||||||...| .   .||..| |.  || ||| |....| .||||| . | . .. ||||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

NDDSAKFGSYSVSILSTSSDGDVTTRQLKVT-----RNSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKKEfSILVHCLSGSGRTGVF
.. .  .|   |..  .    |.| |.. |.     .. |.|  |.|. |..||. |   .|  . ..||...||.  ... . .| ||| .| |||| |
deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep..iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtf

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREY-LH
..    ....     ||.|..|| ||. | | |||.| | | |.|..|| |.
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 573-848 2.1e-58 192.6 In-house 6-282 (287) alignment 
Range on Protein: 573-848
Range on HMM: 6-282/287.0
HLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPpASQTrSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFW
.. ..  .|  .|.   .. |..|...  ..  . |  . ...|..|||. . |. . .||.|   ..|||||....| .    || .. |.  |. .||
kfgefvakghakgnegfknqftvleqvtqre.devt.hniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

SMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKA--SHTVTQYQFHGWPKHGSDQQPgARSLMKLIRA
 .. | ....|||| . | . .. | ||||...|  .| |....|.     ... |.|.|....||   ..|.|||.  |...|  ..| . .|. . . 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieem

VKSStNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
.|.   |. . ||.|||  . ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| | .... |||.. .
yktq.rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_PTPN6_pd Subfamily PTPN6 570-848 8.5e-58 190.7 In-house 9-301 (306) alignment 
Range on Protein: 570-848
Range on HMM: 9-301/306.0
FTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPAsQTRSGRTPDNQPKNRYGNNLPLERNRVIL---DSSDHDYINASYMK----GVHCTFITTQMPL
  .. ..|. ...  ... ...||..|.         . . |. |.|. |||| | || . .||||   . ...|||||.|.|    | ....|.||  |
ieqrvselekeeeslekagfeeefeelqqeeakkll.srkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl

PTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDDS-AKFGSYSVSILSTSSDGDVTTRQLKVT--RNSKASHTVTQYQFHGWPKHGSDQQPGA
.|||||||.||.. .   |||.  .     . ||.|||.  .  ..|..||. .| .|  | . |.|.|.  ...| ...| ||.|. || ||  ..|||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpga

R-SLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQI---AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
  .... ... ......... .|.||| .| |||| |      . .|        .|| ..||..|. | ..||||. | | |..|..|..|..
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
0037934 (Phosphotyrosine protein) phosphatases II 359-556 4.9e-57 188.6 In-house 2-240 (243) alignment 
Range on Protein: 359-556
Range on HMM: 2-240/243.0
QTVAQKEINLKKNRYKNILPYDSARVKLeviddiPHSDYFNASYIPSFDNdkaYIASQGPNIASMDD----FWRMVWQENVTTIAMVTKLKEG-------
...|... ||.||||..|||||  ||||      . |||.||..|. ...   .||.|||   . .|    ||||.|....|.| |.|.|.|        
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

---------------------------------DK-GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD----------HGQftHPLIIHCSAGVG
                                  . .| .|.|...|.. ||| ||| ....||.|..||..           ...  .|...|||||||
ywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsaGvg

RTGVVISIDSVVAHAkttRmVDVFNFVTNIRQKRPF-MVQTQEQYAFIYGAVLE
|||..| .. .  .    . ||... |  .|..||. .|||..|| |.| |.||
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN23_pd Subfamily PTPN23 584-846 5.2e-57 187.9 In-house 12-282 (288) alignment 
Range on Protein: 584-846
Range on HMM: 12-282/288.0
RGRSKMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVHC---TFITTQMPLPTTVSDFWSMVFDFKPST
 |.... |.|. |..      | ..       .  |||. . || ..||| |..|  ||||||..|..     .||.|| ||..|..|||.||.. | |.
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLNDKGQSDKS-CAQYWPND--DSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-SKASHTVTQYQFHGWPKHGSDQQPGarSLMKLIRAVKS---STN
|||| .| . .|  ...|||.|  .. ||| .||.. |. . . .  |.||.. . ..| ..|.  |.. ||..|  . |.  .|.... .|.|   ...
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPe..tllqfldevesayeavq

KKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
.| .  ..|||..|.||||||.  .  .... .|. . || | |. ||..|   ||..|.. |.||.. |. . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Ptp69D_pd Subfamily Ptp69D 589-848 6.3e-57 188.0 In-house 24-290 (307) alignment 
Range on Protein: 589-848
Range on HMM: 24-290/307.0
MTKEFQTLKSLcpdPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIV
..||...|..        .|. .   .|. |||| .  . ...||.|       | ||||||..||   . .||. | |. .|. ||| |. . .  .||
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLNDKGQSDK-SCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS------KASHTVTQYQFHGWPkhGSDQQPGARSLMKLIRAVKSSTNKK
|| . .. ..  ||.|||..|  ..|.  | . |... .| . |.|.|...       ..|. |.||.. ||.   |     ||.|.|||. |..  ...
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklieqvrelykln

kEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 .  |.|||  |.||.|.| .    . |. . |.||||.||| || .|  .||  | | | |  . .| .  .
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
0037934 (Phosphotyrosine protein) phosphatases II 611-844 1.3e-56 187.2 In-house 5-242 (243) alignment 
Range on Protein: 611-844
Range on HMM: 5-242/243.0
GRTPDNQPKNRYGNNLPLERNRVILdsSDHDYINASYMKGVHcTFITTQMPLPTTVSD----FWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPndDSAK
.. | |..|||| . ||....||.|  ...|||||......  ..| ||.||| || |    || |... . ..||||..    . . ||||||  ..  
allpenlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

FGSYSVSILSTSSDGDVTTRQLKVTR--NSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNK-------KKEFSILVHCLSGSGRTGVFCT
.| ..| .||... .|.| | |....   .. ...|..|....|| ||  .     .|......|..  ..       ...  .||||  | ||||....
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds..pedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AMECIAQIaegdSVDIFQTVKILRADRMQ-FVQTEEEYAFTYEVIREYL
|  .. ..    .||....|| ||. |..  |||.. | | ||...|.|
aylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 585-846 2.4e-55 182.5 In-house 6-279 (290) alignment 
Range on Protein: 585-846
Range on HMM: 6-279/290.0
GRSKMTKEFQTLKSLCPDPPASQ---TRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFD
|. ...||||.||.|     |..   | .|... |. |||| . || . .|| |       . |||||...|||.  ...| .| |||.|..||| |...
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

FKPSTIVMLNDKGQSDK-SCAQYWPND--DSAKFGSYSVSILSTSS-DGDVTTRQLKVTRNsKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSS
.. . .||.  .   .|  |..|||.   .. .||...|.  .    | | . |.|||... |.|..|.|.... || ||  ..  | ||..||..|.. 
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPss..aksllelielvrel

TNkKKEFSILVHCLSGSGRTGVFCTA---MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
 . ...  ..||| .| ||||. ..     | . .    ...|.|. |  || .|   |||.| | . |. . |....
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 604-842 4.8e-54 178.2 In-house 21-264 (283) alignment 
Range on Protein: 604-842
Range on HMM: 21-264/283.0
PASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMK-----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDK-GQSDKSCAQY
|  ..    . .|..|||. . .| ...|| |.|  .|||||...           .| .| ||  || ||| |||| | ..||||     . .. |.||
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS--HTVTQYQFHGWpkHGSDQQPGARSLMKLiRAVKSSTNKKKEFSILVHCLSGSGRTGVFC
||.. | ..| . |..    .    . ..| .  || |     .. ||. .|     ..|.   ||.|.   |.|  ...|.  |.||| .| |||.||.
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkf.nkvislqteskkgPivvhCstgiGrtavfi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
.|.  . ..     ||.|..|||.| .||  ||| . | . .|.. |
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 588-845 1.2e-53 177.5 In-house 35-293 (319) alignment 
Range on Protein: 588-845
Range on HMM: 35-293/319.0
KMTKEFQTLKSLCPdPPASQTRSgRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTI
|.  ||. .  | . . | || .   ..|. |||..| |. ..|.| |.  .     ||||||...|      .|..| ||. |. ||| |..... |||
klevefrracklgv.nladqtfa.nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLNdkgqsDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKK-EF
|.|       . |.||||..   | . . |.. |     . . |.......   |    .||. | |||..|  ..|    ||.|.. |.  |.|.. . 
vllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp..sdlmrlvkkvrhltskenhra

SILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE-YLH
.|.||| .|.|||||. .    . .. | . ||....|. || .| ..||   .| | |  . | .| 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 605-845 1.1e-52 174.3 In-house 15-257 (284) alignment 
Range on Protein: 605-845
Range on HMM: 15-257/284.0
ASQTRSgRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNdkgqsDKSCAQYW
. || .   ..|. |||.|. |. ..|.| |.  .     ||||||...|      .|.|| ||. |. ||| |..... ||||.|      .. |.|||
tdqtfa.nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqyw

PNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKK-EFSILVHCLSGSGRTGVFC
|..   | . . |.. | .   . . |.......   |   ...|. | |||..|  ..|    ||.|.. |.  |.|.. . .|.||| .|.|||||. 
plkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp..sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE-YLH
.    . .. | . ||....|. || .| ..||   .| | |  . | .| 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 735-848 1.1e-52 173.8 In-house 170-280 (515) alignment 
Range on Protein: 735-848
Range on HMM: 170-280/515.0
ASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKeFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
 |.||||..|..||..|....  ..||.|||..||..... . .....||..| |||||........|.......||.|..|...|..|...|||.|.||
dsrtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqya

FTYEVIREYLHTEN
| |....|.|.  |
fiygavledllwrn
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 588-846 3.1e-52 172.4 In-house 16-278 (281) alignment 
Range on Protein: 588-846
Range on HMM: 16-278/281.0
KMTKEFQTLKSLCPDPPASQTrsgRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTI
 ...|...|...  | .|. .   ....|. |||| |    .  || .    .... |||||....|..    .|.|| |.|... .|| ||.. | |.|
Gfieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLNDKGQSDK-SCAQYWPNDD-SAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKKEFS
||.  . ...|  | .|||.|. . |.| . |. .....     .|..|..|.|  . .|.| ..  || ||  ...  . |..  ..|.. |.||.. .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPatt..kellefrkevlkltekktkap

ILVHCLSGSGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
...|| .| ||||.. .    . ... |  ..|. ..|. || .|. .|||   |.| | .. ..|. 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN9_pd Subfamily PTPN9 575-844 3.3e-52 172.4 In-house 4-290 (297) alignment 
Range on Protein: 575-844
Range on HMM: 4-290/297.0
QDLHSSGDGRGRSKMTKEFQTLKSlcpDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQMPLPTTVSD
..| .    .|.. ..||.. ...    |.. .    ... |  |||| . | ... || | . |     |||||... |   . .||.|| ||. ||||
eelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWP--NDDSAKFGSYSVSILSTSSDGDVTTRQLKVT-RNSKASHTVTQYQFHGWPKHGSDQQpgARSLMKL
|| ||.. .  .|||     .     |.||||  ...||.||..||| ... .  | ..|.|...  . . | .|| .|| .|| .|  ..  | ||...
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslldv

IRAVK---SS---------TNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
...|.   ..         . . ..  |.||| .| |||| |.|   |.... | . ||...||| ||. |   .||.| |.| |  . || 
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 322-449 1.7e-50 166.9 In-house 6-131 (297) alignment 
Range on Protein: 322-449
Range on HMM: 6-131/297.0
KRQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNdkAYIASQGPNIA
.|.|||...|......|||. .|| ||..||   |.|||||.| .|..|.|||||||||| ||||....| | |||.|||..... .   .|..| |. |
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

SMDDFWRMVWQENVTTIAMVTKLKEGDK
...|||.||..|.|.||.|.....|.||
tvadfWamvldeqvstivmlnddnerdk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 611-842 3.7e-50 165.7 In-house 44-277 (315) alignment 
Range on Protein: 611-842
Range on HMM: 44-277/315.0
GRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQ-YWPNDdS
 .   |. |||| | .. .. || |      .. ||.||....|      .|..| |....| ||| .||. . ..||||..  . .|. |. |||..  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAsHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKSSTNKKKeFSILVHCLSGSGRTGVFCTAMECIAQ
  .| ..|.  |     ..| | | |. ...  ..| |...  ||. |      . .||.||| ||   ...   .|.||| .| |||| |.|    . |
viyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
.   . .|... .. .|. |.. ||. |.| | |... |
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_CG7180_pd Subfamily CG7180 586-845 7.8e-50 164.2 In-house 12-291 (296) alignment 
Range on Protein: 586-845
Range on HMM: 12-291/296.0
RSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPS
| |.  |.. .  | |     . . |   .|. |||. . .| . |||.|..    .. |||||.|. .   .  .| |..|   || .||..|.| . |
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIVMLNDKGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-----------SKASHTVTQYQFHGWPKHgsDQQPGA-RSLMKLIRA
..|.| ....  | . .||||.  ...|   | |... .  ....|..|.|..           .    .|...|.  |. .  |. |    .|..|.| 
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele..dkvPlstnalielrrr

VKSSTNKK----KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
|..  .|     .|  ..|..  |..|.||....  .. .. . . ||.|. || || .| | |.. ||| . |.|. |.. 
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 609-845 1.5e-49 163.6 In-house 21-269 (274) alignment 
Range on Protein: 609-845
Range on HMM: 21-269/274.0
RSGRTPDNQPKNRYGNNLPLERNRVIL-----DSSDHDYINASYMKGVH---CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWP
.  . . .| |||| . || |. ||.|     ...| .|||| |.|| .    ... || |||.||.||| |..  . . |||| .  ....  ||.|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

NDDSA----KFGSYSVSILSTSSDGDVTTRQLKVTRNSKaSHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKEF--SILVHCLSGSGRTGV
.. ..    ..|  .. . .. .  | . |.| .   .. ...|. | .  || | | ..  |..|..|.. |..| .....   ...||| .| ||||.
daedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGc

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
| ..  .. |. |   ||....|  || ||   |||.| | . .... .||.
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 603-841 4.6e-49 161.8 In-house 28-272 (280) alignment 
Range on Protein: 603-841
Range on HMM: 28-272/280.0
PPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMK------GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCA
 |  ..   | |.| .|||| . || .  ||.|..|. |||||.|..      |.   .|.|| ||..|..||| ||.. | |.|||| .  .. .  | 
kpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPN-DDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGV
||||. .|. ..|..|| . .....  . .|.| ..... | .....| |.  || ||  ...   ....... |..  .  ||  ..||| .| |||||
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds..adflefvervrklrs.gkeePvvvhCsaGigrtGv

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIR
. .   ..| | . ..| . . |. .|  |. .|||.. | |  | | 
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN13_pd Subfamily PTPN13 590-845 6.5e-48 158.3 In-house 14-270 (273) alignment 
Range on Protein: 590-845
Range on HMM: 14-270/273.0
TKEFQTLKSLCpdpPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHdYINASYMKGV----HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLN
..||..|. |    |  ....|.. .|. |||| | || .. ||.|...   |||||..|      . ..| .| |||.||.||| ||.. | . |.|. 
aeefkelrelk...pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

DKGQS-DKSCAQYWPNDDSAKFGSYS---VSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNkkKEFSI
 . ..    | .|||.  . |   ..   |. | .    . . |.|.|.  .|..|. |.. .|  || ||  ...   .|..... |..  .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssa..aellqfvaevrrlqt..dagPi

LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
.||| .| ||.|.. |    .  |.   ..|. ..|. ||  |   |||.. | | |..| | |.
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 453-571 4.1e-47 155.7 In-house 176-297 (297) alignment 
Range on Protein: 453-571
Range on HMM: 176-297/297.0
YRTVTQFHFTEWPDKGVPK--HTSSLLKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
 | | |..|.||||| |..  ..|||||.|.||. |..| .. ||..||.||||||||...||||||.|| .  ||.|..|. .||.||..|||.|||.|
rrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykf

IYGAVLEDLLWRNTLIPVVHFT
.| |||| ||  .| |.. .|.
vyvavleallsedtriqasyfe
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 616-847 2.1e-46 153.1 In-house 20-267 (270) alignment 
Range on Protein: 616-847
Range on HMM: 20-267/270.0
NQPKNRYGNNLPLERNRVILDSSDH----DYINASYMKG---VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSA---
..  ||| . ||  . ||.|.. ..     |||| |..|    ....|... |||||...|| |... | ..|||. . . .  | |..|||..      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-KFGSYSVSILSTSSDGDVTTRQLKVTRNSKAsHTVTQYQFHGWPKHGSDQQPG----ARSLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCTAM
 ..|  .|  ||.. .    ...|.......  . .. .... || ||  ....    ...|.|..|||. |......   .||||  | ||||.. .  
ledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
 ..  . |  .||. . .. || |||..||. |.|.| |....|| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN14_pd Subfamily PTPN14 605-845 7.2e-45 148.2 In-house 38-297 (300) alignment 
Range on Protein: 605-845
Range on HMM: 38-297/300.0
ASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS---DHDYINASYMK----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDK-GQSDKSCAQ
 ... ... |.|..|||. . || | ||| | ..   ...||||| .|    | . ..|..| ||..|| ||| ||.. . . |||| ..  .  . . .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPND----DSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQQP-GARSLMKLIRAVKSSTNKKK-----EFSILVHCL
|.|..    ....|| . |.   ... . |.|..||.    ||   ||   |.  ||.||  . . |  | .. ...|.  ||...     .  .||||.
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

SGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
 | |||||  ..   || .  ....|| .....||  || .|||   | | |.|. .||.
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRD_pd Subfamily PTPRD 323-449 2.4e-44 146.9 In-house 2-130 (564) alignment 
Range on Protein: 323-449
Range on HMM: 2-130/564.0
RQPIPVAQFPAFIENNR--HSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNI
..|||||........ .  ... |. |....  ..  . ..|.|..| .||||.||..||. ||.|. ..  . ||| |||.| .....|||||.|||  
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMVWQENVTTIAMVTKLKEGDK
 ...|||||||..|..|| |.|||.| .|
etiedFWRmvweqnsstiVmltkleEkgk
0041856 (Phosphotyrosine protein) phosphatases II 367-566 5.1e-44 145.4 In-house 1-179 (182) alignment 
Range on Protein: 367-566
Range on HMM: 1-179/182.0
NLKKNRYKNILPYDSARvkleviddipHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTkLKEGDKGDDYRTVTQFHFTEWPD
||.||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|     .  . .|...|.... |||
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpD

KGVPKhTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIP
 |||  ...||.||.||..      .| ..||||||||||... .. .  .      |.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
hgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 450-596 5.3e-44 145.6 In-house 171-318 (318) alignment 
Range on Protein: 450-596
Range on HMM: 171-318/318.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH-GQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
 .. |.| |.|.|.|||.|||....|||.....|.. .  . ..|...||||||||||| | .|... ..|   .||||..|...|..|. ||||..|| 
eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqye

FIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTL
||| ..|| |   .| .   ........|. .    |...|  ||| |
fiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_PTPRA_pd Subfamily PTPRA 451-592 9e-44 144.7 In-house 188-329 (330) alignment 
Range on Protein: 451-592
Range on HMM: 188-329/330.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. | |.||||| ||| ||| ..  .||..|.||. . | . |...||||||||||  | .|.|..  |. |.||||.|| ..|..|| ||||.||| ||
kksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

YGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKE
| ..||  |. .| . |. .  ||| |...  |  .  . .|
ykvlleyylygdteldvsslekhlqklynkitgtdkigleee
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 590-848 4e-43 142.2 In-house 18-297 (301) alignment 
Range on Protein: 590-848
Range on HMM: 18-297/301.0
TKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS------DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTI
 .....||.  ..    ..  | . .|.. ||. |. ... ||.||          ..||||||..|.     || .| |.  |. ||| .... ||..|
eeqykelkegedk....sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLNDKGQS-DKSCAQYWPN--DDSAKFGSYSVSILSTSSDGDVTTRQLKVT----------------RNSKASHTVTQYQFHGWPKHGSDQQPgaRSLM
||. .. ..  ..| |||||   .| .||  .| . ..    | . |||.|.                ...|.|..|.|.|   ||..|  ..|  |  .
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep..rtvL

KLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
. |  |   ..|     ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | . |.|| .||. ..
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_PTPN1_pd Subfamily PTPN1 607-842 1.1e-42 140.7 In-house 23-269 (290) alignment 
Range on Protein: 607-842
Range on HMM: 23-269/290.0
QTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYM--KGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPNDDS
.||. ..| |...||| .  | .  |..|...| |||||| .  . ..  .| || ||| ||. || ||.. |  ..||||    ..   ||||||....
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

---AKFG--SYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQQPGArsLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCT
    ..   ...| ..|. .    | |.|...  ... ....... .  ||  |  . |.|  ..|..  |..|   ...    ..|| .| ||.| || 
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa..flkflfkvresGslssdvGpavihcsaGiGrsGtfcl

AMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
.  |...| . |    ||| ...  ||  |. ..|| .   |.|  | |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 453-594 7e-41 135.3 In-house 177-319 (319) alignment 
Range on Protein: 453-594
Range on HMM: 177-319/319.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD-HGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
 |.|..|..|||||..||... |||...|...   ...   |...||||||||||  | .| .. . |   ..|||..| ..| .|..|||..||| |||
tRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiy

GAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
 |.|| .   .| | | .. | |..| .   . | ... .|||
ealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
subfamily_PTPRN_pd Subfamily PTPRN 585-842 8.8e-41 134.5 In-house 27-290 (297) alignment 
Range on Protein: 585-842
Range on HMM: 27-290/297.0
GRSKMTKEFQTLKSLCPDPPASQtrSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV---HCTFITTQMPLPTTVSDFWSMVFDFK
 .... ||...|..   .| ...   .....|  |||. . || . .|| |..    ...|||||| .      . ..|.|| ||..||.||| ||..  
nkdrlekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

PSTIVMLNDKGQ-SDKSCAQYWPNDDSAKFGSYSVSILST---SSDGDVTTRQLKVTRNSKaSHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTN
   ||.|    . . | |..|||.. |. .. | | ..|    . |  | .  ||  ..|. . ||||. |  ||..|   .  |.||... | |  |  
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPas..aksllefrrkvnksyr

KkKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
  .  .|.||| .|.|||||..     ..... |   .||  |.. || .| ..|.|.... |.. .. |
G.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 615-841 1.1e-40 134.4 In-house 2-236 (237) alignment 
Range on Protein: 615-841
Range on HMM: 2-236/237.0
DNQPKNRYGNNLPLERNRVILD--SSDHDYINASYMKGVHC---TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPNDD-SAKFG
.|. ||||||    . .||.|    |. |||||.|.||.     ..|..| || ..  ||| ||.. | | ||||    .  .. | .|||. |  | .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVSILSTSSDGDVTTRQLKVTRNS--KASHTVTQYQFHGWPKHGSDQQPGArsLMKLIRA-VKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQI
 ..||.       | | | | ....   |    . ||||  ||..|  ||  |  |... .  .. |    .    ..|| .| ||||.|      . | 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIR
 |   |||.. |. .  ||   .||...| | ...| 
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 452-578 3e-40 133.3 In-house 176-303 (305) alignment 
Range on Protein: 452-578
Range on HMM: 176-303/305.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
. |||.|...|.|||.|||. ..|||..||.|. |. .    ||..||||||||||| |..|  . ..|.  .||||. . ..|.||. ||||..|| |.
esrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl

YGAVLEDLLWRNTLIPVVHFTDHLQDLH
. |. | .   .| | .  .. ... |.
hdaldelitcgdtsiigsnlrarvnklk
subfamily_PTPRK_pd Subfamily PTPRK 451-595 3.8e-40 132.6 In-house 170-314 (314) alignment 
Range on Protein: 451-595
Range on HMM: 170-314/314.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
...|.| ||.|. ||| .||..  .|||....||. . .   ....||||| ||||. | ||.|.  ... ..||||| | ..|.... ||.|.||| ||
eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

YGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQT
| ..||  |  .| ||| .|     .          |.. .||||
ydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 588-847 6.7e-40 131.7 In-house 11-280 (287) alignment 
Range on Protein: 588-847
Range on HMM: 11-280/287.0
KMTKEFQTLKSLCpDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS---DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIV
.. ||...||    .  .   ..     .  ||||.. ||.. .||.|        ||||| |. . .   .||..| |...|| ||| .|.. . ....
dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

ML-NDKGQSDKSCAQYWPNDD-SAKFGSYSVSILST-SSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKSSTNKKKE-
..  .  .. . | .|||. .   . | ||| .|.    . . ..| |..     . .. | |...  ||...    | | .|....  ||   . ... 
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvl..aPtavglirfvldvkqhielarda

---FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
     ..||.  | ||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|| .  | .|.
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
0051429 (Phosphotyrosine protein) phosphatases II 392-557 7.6e-40 132.6 In-house 1-224 (272) alignment 
Range on Protein: 392-557
Range on HMM: 1-224/272.0
IPHSDYFNASYIPSFDN---DKAYIASQGPNIASMDDFWRMvWQENVTTIAMVTKLKEGD----------------------------------------
.| |.|.||.... . .   ......|.||  .. .||||. ......|| ..... | .                                        
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

---------------KGDDYRTVTQFHFTEWPDKGVPKHTssLLKFIKEVKAdhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVD--------
               . ...|.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ...    . .||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFNFVTNIRQKRPFMVQTQEQYAFIYGAVLED
....|  .|..|| .|||.|||.|.| |.|| 
leeaveelraqrpgavqteeqylflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 395-551 8e-40 131.7 In-house 2-163 (174) alignment 
Range on Protein: 395-551
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNDKAYIASQGPNIasmddFWRMVWQENVTTIAMVTKLKEGD-----------KGDDYRTVTQFHFTEWPDKGVPKHTSsLLKFIKEV
|||.|||..  .   . .||.|||       ||.|......||. |....|| .           . | .|.. |.... ||| |||  .  ||.|.|.|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfv

KADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKtTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
.  . .   .|...||||||||||... .. .  . . ...||....|  .|..|| ||||..|| |.|
eealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 452-563 5.3e-39 129.2 In-house 183-295 (298) alignment 
Range on Protein: 452-563
Range on HMM: 183-295/298.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT-HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
. |.| |.|||.|||||||....|.|.....|.| . |   .|.|..|||||||.|  | ||||. ..|. ..||||. |  .|.||| .|||.|||.||
kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

YGAVLEDLLWRNT
| |||| |   |.
yeavlealdsfnd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 452-558 1.9e-38 127.1 In-house 135-242 (250) alignment 
Range on Protein: 452-558
Range on HMM: 135-242/250.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
| |.| |.||. |||||||... . |...|.|.| . |  . |.|..|||||||.|  | ||.|. ..|. ..||||...  .|..|| .|...||| |.
derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfv

YGAVLEDL
| ..|. |
yeiilkal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 601-708 2.1e-38 126.8 In-house 30-152 (392) alignment 
Range on Protein: 601-708
Range on HMM: 30-152/392.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-----KGQ
|.|............|..||||.|.||....||.|    |..|.||.||||......  ..|..|.| .....|||.|||.....||.|...     ||.
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

SDKSCAQY----WPNDDSAKFGS
.....||.    ||..|  |. |
dartvaqfhftewPdkdvpkhts
0041856 (Phosphotyrosine protein) phosphatases II 616-849 2.2e-38 127.0 In-house 1-176 (182) alignment 
Range on Protein: 616-849
Range on HMM: 1-176/182.0
NQPKNRYGNNLPLERNRvildssDHDYINASYMKGVHCT--FITTQMPLPTTVSDFWSMVFDFKPSTIVMLNdkgqsdksCAQYWPnddsakfgsysvsi
|..|||| . || ...|      | |||||... | . .  || || ||. || ||. |. . . .|||.|.        . .|||              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..............

lstssdgdvttrqlkvtrnSKASHTVTQYQFHGWPKHGSDQqpgARSLMKLIRAVKSstnkkKEFSILVHCLSGSGRTGVFCTAMECIAQiaegdSVDIF
                   ..  ....||....|| ||       ..| ..|..|..     ..  .||||  | ||||... |  .. .     .|...
...................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

QTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENY
..|| .|  |.. |.|.. | | . ...|.|.  ..
eavklvrsrRpgmvitpnqyfflqlallellllkkt
0043147 (Phosphotyrosine protein) phosphatases II 393-551 5.3e-38 125.8 In-house 3-154 (172) alignment 
Range on Protein: 393-551
Range on HMM: 3-154/172.0
PHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLkEGDKGDDYRTVTQFHFTEWPDKGVPkHTSSLLKFIKEVKA-DHGQFT
..||| ||||..     . .|| |||    ..|||||......|.| ..|.| . |. . .|.. |.... ||| ||| ... ||.|.. ..   . .  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspg

HPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
.| ..||||||||||... .. .       . ..... |  .|.||| .||...|| |.|
gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
subfamily_Ptp69D_pd Subfamily Ptp69D 449-577 2.9e-37 123.5 In-house 177-305 (307) alignment 
Range on Protein: 449-577
Range on HMM: 177-305/307.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
. .| | |.|.|.|.|.|  ||... .|||.|..|.  . .   |...||||||||.|.....||.. . |.   ||.|..| ..|..|...||  ||| 
evedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYv

FIYGAVLEDLLWRNTLIPVVHFTDHLQDL
|.| |.|.   . .| . | .. |... |
flyralldyssygdtdedvddledaierl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 587-844 3.7e-37 122.8 In-house 6-259 (267) alignment 
Range on Protein: 587-844
Range on HMM: 6-259/267.0
SKMTKEFQTLKSLCPDppASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVML
 .. |||. .| . ..   |.     . .|| .||. .||| . .||||  ....||||||..| .   .|| || ||  |..||. .. | | ..||.|
ceiekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDKGQSDksCAQYWPND--DSAKFGSYSVSI--LSTSSDGDVTTRQLKVtrNSKASHTVTQYQFHGWPKHgSDQQPGARSLMKLIrAVKSSTNkkKEFSI
   .. .    ..||    .. |.   .|         | .. | .||.  . ...| || | .. |    ....|  . |. .. | .   |   .  .
tkvftdn..irlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnin.tnnkpylkplfgil.aknqlen..gnrPl

LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
.|.|  | ||.| | ..   . .. . . .|||. .. .|  |. .|.| |.| . .|.. || 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_PTPRB_pd Subfamily PTPRB 449-556 4.6e-37 122.6 In-house 174-283 (293) alignment 
Range on Protein: 449-556
Range on HMM: 174-283/293.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH--GQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQ
|... |.|.|.||| ||| |||..|..||.|...|.  .   . ..|...||||||||||. |..| .. . ... .||.| .|...|..| ..|||..|
kekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YAFIYGAVLE
| ||. .||.
Yifihqcvld
0051429 (Phosphotyrosine protein) phosphatases II 640-846 5.5e-37 123.2 In-house 4-227 (272) alignment 
Range on Protein: 640-846
Range on HMM: 4-227/272.0
HDYINASYMKGVhCT------FITTQMPLPTTVSDFWSMvFDFKPSTIVMLNDKGQSDK-SCAQYWP------------NDDSAKFGSYSVSILSTSSDG
 .||||....|  .       .. ...||| |. ||| .  . . .|||.| .    ..  | .|||             . .  .| ..| .||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQPgARSLMKLIRAvksstnkkkEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVD-------
|.. | | .|.    .....|.......|| ||  |..  ..|..|...         .  .|||| .| .|||... .  ..... . . ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
 ....|. ||| |...||||| |.| ||...|.| .
yleeaveelraqrpgavqteeqylflyeallellrs
subfamily_PTPN12_pd Subfamily PTPN12 451-556 1.5e-36 120.8 In-house 167-275 (290) alignment 
Range on Protein: 451-556
Range on HMM: 167-275/290.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPFMVQTQEQY
.. |.|.|||.|.|||.|||. ..|||..|..|.  . .  .||..||||||||||..|.|| |    |. ..   .|||. |...|..|. .|||.|||
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

AFIYGAVLE
 ..| ||.|
elvykavae
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 588-849 3.8e-36 119.2 In-house 28-288 (290) alignment 
Range on Protein: 588-849
Range on HMM: 28-288/290.0
KMTKEFqtLKSLCPDPPASQTRSGrTPDNQ---PKNRYGNNLPLERNRVIL-DSSDHDYINASYMKGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVM
...||.  |. | |  |. .       |..    |||| .    .. |||| |  | ||. | |.||.. .|| || .|  || |.| || . | ..|||
elakey..leklkpylpvqylerk.ifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivm

LNDKGQSDK-SCAQYWPNDDS--AKFGSYSVS-ILSTSSDGDVTTRQLKVT-RNSKASHTVTQYQFHGWPKHGSdqqpgARSLMKLIRAVKSStnKKKEF
| .  .  |  |.||.|. .     ||...|   .... | ..  . | |  ..|  .| .  ..   || .       | | . |.| ...   .|   
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtlril..rkasG

SILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENY
 . ||| .| |||| | .   ..  . .| ..|. ..|. ||  |.. || . .|    |.. ..    .|
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
0049772 (Phosphotyrosine protein) phosphatases II 360-560 4.8e-36 120.5 In-house 39-282 (314) alignment 
Range on Protein: 360-560
Range on HMM: 39-282/314.0
TVAQKEINLKKNRYKNILPYDsARVKLEvIDDIPHSDYFNASYIPSFdndKAYIASQGPNIASMDDF----------WRMV--WQENVTTIAM-------
.||... | .||||..|||.|  ||.|    ..  |||.||||. .|   ...||.|||.   ..||          ||||  .. || .| |       
lvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTKLKEG----------------DKGDDYRTV-TQFHFTEWPDKGVP--KHTSSLLKFIKEVkadhgQFTHPLIIHCSAGVGRTG-
               ..| ..                . ....     ... . .|| ..|  ..  ..|.||.|.     .  .|...||.||.|||| 
delsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgt

-VVISIdsVVAHAkttRMvDVFNFVTNIRQKRP-----FMVQTQEQYAFIYGAVLEDLLW
 ||. .  .. .    .. ..   .  .|.|||      .....||| ||. |.|| | .
fvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-449 5.3e-36 119.1 In-house 3-131 (315) alignment 
Range on Protein: 323-449
Range on HMM: 3-131/315.0
RQPIPVAQFPAFIENNRHSA--LFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNI
.||||. |. ... ... |.   |  ..  .|| ...|  ||.|  | .|||| ||..|| .||.| ...  ||||| ||..|. ..  . |||.||||.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMVWQENVTTIAMVTKLKEGDK
||..||||.|..|....| |.|.| ||.|
asvkdfwrlvfeedigkivmltnlvegek
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 587-844 6.1e-36 118.8 In-house 20-279 (439) alignment 
Range on Protein: 587-844
Range on HMM: 20-279/439.0
SKMTKEFQTLKSLCPDPPASQTRSGRTPdNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPST
  ....|....|  ||  .  .   .   .|.|||| .  ...  ||.|          |||| |.|| .    .|.||.|   |. ||| .|.. | .|
eifkeifekinstspdyaciaslaaqey.dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IVMLNDKGQSDKscaqYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN---SKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKE
|||| .  .| |    ||| |. . .|  .| .       . . | .||  .   ..  .|| |...  ||..    |  |  .....||..|. .|.. 
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeey

FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
  ..||| .| ||||   .   .. |.   . |||   ||.|| .| |.||.  .| | |. . | .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
DSPc_SM00195 451-556 6.9e-36 119.3 In-house 155-260 (263) alignment 
Range on Protein: 451-556
Range on HMM: 155-260/263.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||... . ... .||.|. |...|..|| ||||.|||.||
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

YGAVLE
| |.||
yeaile
PTPc_SM00194 451-556 6.9e-36 119.3 In-house 155-260 (263) alignment 
Range on Protein: 451-556
Range on HMM: 155-260/263.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||... . ... .||.|. |...|..|| ||||.|||.||
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

YGAVLE
| |.||
yeaile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 447-579 9.4e-36 118.7 In-house 178-312 (319) alignment 
Range on Protein: 447-579
Range on HMM: 178-312/319.0
GDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQ
  |  | | .|||||  |||.|||...| |....| |.  . .    .....||||||||||| | .| ..   |  ..|||.||| ..||.|. .||  
dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

EQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHS
 || ||| |.||. |. .. . .  |  .|..| .
vqykfiysalleehlfghsdvampdfpayleelsn
Y_phosphatase Protein-tyrosine phosphatase 452-556 1e-35 118.6 Pfam-A 131-235 (235) alignment 
Range on Protein: 452-556
Range on HMM: 131-235/235.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ...... |||...| ..|..|| |||. |||.|.|
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

GAVLE
 |.||
kaile
Y_phosphatase Protein-tyrosine phosphatase 452-556 1e-35 118.6 In-house 131-235 (235) alignment 
Range on Protein: 452-556
Range on HMM: 131-235/235.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ...... |||...| ..|..|| |||. |||.|.|
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

GAVLE
 |.||
kaile
subfamily_PTPRG_pd Subfamily PTPRG 442-562 2.1e-35 117.0 In-house 171-291 (563) alignment 
Range on Protein: 442-562
Range on HMM: 171-291/563.0
TKLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMV
.|||.... |. ..|.|.|.|.|||.|||.|.   |.|.|  .| . . . |...||||||||||. | .|...   ..  .|.||.|.  || .|.|.|
lklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflv

QTQEQYAFIYGAVLEDLLWRN
||.||| |.. |.|| .. ..
qteEqYiflhdalleaiaske
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 450-577 2.1e-35 117.2 In-house 171-298 (315) alignment 
Range on Protein: 450-577
Range on HMM: 171-298/315.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
||. |.| |.|.| ||| ||||.| .|...|. ||  | .   ....||||||||||  |..|.|. .|.. ...||.||.|..||.|  |||. ||| |
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqf

IYGAVLEDLLWRNTLIPVVHFTDHLQDL
|| |.|| ..  .| |    . .. . |
iydalletfvcgdtsiaqdlylqrydsl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 450-558 2.4e-35 117.0 In-house 166-276 (281) alignment 
Range on Protein: 450-558
Range on HMM: 166-276/281.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLIIHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPFMVQTQEQY
. . |.|.|...| |||.|||. |. ||.| |||.  .  .  .||.|||||||||||. |..| .| .. ......|| . |...|..| .||||  ||
sgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

AFIYGAVLEDL
.|.| |||. |
efvykavldal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 451-555 3e-35 116.7 In-house 172-276 (288) alignment 
Range on Protein: 451-555
Range on HMM: 172-276/288.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
 . ...||.... |||.|||. .  ||.... ||  . . | |.|.||||||||||. |..| .. . ... ..||...|...|..|...|||..|| ||
kteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

YGAVL
| ..|
yevll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 447-578 4.5e-35 116.5 In-house 142-275 (284) alignment 
Range on Protein: 447-578
Range on HMM: 142-275/284.0
GDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQ
  |  | |...||||  |||.|||...| |....| |.  . .    .....||||||||||| | .| ..   |  ..|||.||| ..||.|. .||  
dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

EQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLH
 || ||| |.||. |. .. . .  |  .|..| 
vqykfiysalleehlfghsdvalpdfpayleels
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 654-841 9.7e-35 114.7 In-house 237-435 (440) alignment 
Range on Protein: 654-841
Range on HMM: 237-435/440.0
TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKgqSDKSCAQYWP-NDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNsKASHTVTQYQFHGWPKH--
.||.||||| .|| ||| .| |.. |||.|||.    ||.|. ||| |  |  || ..|    .     |  | |..  . .  | . |..   ||    
afiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk.eevheirqfevqtwptwiq

--GSDQQP----GARSLMKLIRA--VKSSTNKKK---EFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
  | . |         ||  .|   .. ||.. .      ||||||||   .||||| |.|. |. .  ..|.|| ...||  | .|| |  .| . | .
sdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykl

IR
. 
lt
subfamily_PTPRB_pd Subfamily PTPRB 323-449 1.6e-34 114.3 In-house 4-133 (293) alignment 
Range on Protein: 323-449
Range on HMM: 4-133/293.0
RQPIPVAQFPAFIENNR--HSALFSGEFHDLPGP-DIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPN
 .|| . .| .......    . || |...|        ...|....| .||||.|||||| .||||. ..| ..||| ||.||| .   . .||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

IASMDDFWRMVWQENVTTIAMVTKLKEGDK
  ..||||||||......| |.|.| |. |
petvddfWrmvwekkssiivmltqlvekgk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 324-447 3.5e-34 113.3 In-house 3-128 (319) alignment 
Range on Protein: 324-447
Range on HMM: 3-128/319.0
QPIPVAQFPAFIENNRH--SALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIA
..|.|...   ... ..  . |.  ||..| ...    . |.||.| |||||.|||.|| .||.|  .|... ||| |||.| .... ...|| |.|   
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

SMDDFWRMVWQENVTTIAMVTKLKEG
 ..|||||||.|.. .. |.|||.| 
tiedfWrmvWeeessivvmltklvek
subfamily_PTPRA_pd Subfamily PTPRA 322-448 3.7e-34 113.1 In-house 10-139 (330) alignment 
Range on Protein: 322-448
Range on HMM: 10-139/330.0
KRQPIPVAQFPAFIENN--RHSALFSGEFHDLPGPDIYP-QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGP
|  |.|| ..   |.      . ||  ||  ||  .|     .|.|| | .|||. |||||| .|| | |.. ...||| |||.|  . . . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

NIASMDDFWRMVWQENVTTIAMVTKLKEGD
   ...|||||.|. . .|| |.|.||| .
keetvedfwrmiweqksativmltelkerk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 451-594 3.7e-34 112.8 In-house 86-230 (440) alignment 
Range on Protein: 451-594
Range on HMM: 86-230/440.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
 . ||. |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||.|..||.. .|| .  .|.|.|. ..|..|| |||| |||||
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
.. |||| ||  .|||     |.......       .| . .||.
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
PTPc_DSPc_SM00012 455-556 1.4e-33 110.6 In-house 1-105 (105) alignment 
Range on Protein: 455-556
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
||...|.|.|||.|||....|.|.....||  . .   ..|...||||||||||... .| .. . ... . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 341-449 2.3e-33 110.5 In-house 20-129 (288) alignment 
Range on Protein: 341-449
Range on HMM: 20-129/288.0
SALFSGEFHDLPG-PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIA
 . || |.. |.       .|....  | |||||.||||||  ||||.  .. . .|| ||||| . ...|.|||.|||. ....|||..|......||.
rtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv

MVTKLKEGDK
|.|.| ||.|
mltelveggk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 342-447 4e-33 109.8 In-house 20-126 (318) alignment 
Range on Protein: 342-447
Range on HMM: 20-126/318.0
ALFSGEFHDL-PGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAM
 |.| |.. | . ..   .. . ...| .|||| |||.||..||||. ... . ||| ||.||. . ..|||||.|.|    ..|||||||. | ..| |
lllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

VTKLKEG
.|...| 
ltqeeer
0049772 (Phosphotyrosine protein) phosphatases II 610-845 4.5e-33 110.7 In-house 40-281 (314) alignment 
Range on Protein: 610-845
Range on HMM: 40-281/314.0
SGRTPDNQPKNRYGNNLPLErNRVILDS---SDHDYINASYMKGVhCTFITTQMPLPTTVSDF----------WSMVF--DFKPSTIVM-----------
 .. . |. |||| . || . |||||..   |..|||||||..|. ..|| || ||. || ||          |.||.  |... .|||           
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LND---KGqsdkscaqywP---NDDSAKFGsysvsilstssdgdvttrqLKVTRNSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRA
          |..   .|          .     | . .                      .. ... .... .|  . .| .. .     ......|..
rLdaAlgKtpllildgng..........neptaadlellk...................eelydpelferlgikylripvpDgsaplledfdeflefiee

VksstnkKKEFSILVHCLSGSGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRM-----QFVQTEEEYAFTYEVIREYLH
.      .|.  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... |.| | .|...||| 
a......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0046846 (Phosphotyrosine protein) phosphatases II 389-554 5.2e-33 109.6 In-house 6-169 (176) alignment 
Range on Protein: 389-554
Range on HMM: 6-169/176.0
IDDIPHSDYFNASYIPSFdndkAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK-------GDDYRTVTQFHFTEWPDKGVPKHtSSLLKFIK
. . ...|| ||..| .     ..|| |||   .. ||..|......|.. ..|...| ..        . ..   |.... ||| ||| . . ||....
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllelle

EVKADHGQFtHPLIIHCSAGVGRTGVVISIDsvvaHAKTTRMVDVFNFVTNIRQKRP-FMVQTQEQYAFIYGAV
...    .  .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..|||.||| |.| ..
firealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefe
subfamily_ptpA1_pd Subfamily ptpA1 588-800 5.5e-33 109.3 In-house 22-252 (418) alignment 
Range on Protein: 588-800
Range on HMM: 22-252/418.0
KMTKEFQTLKSLC-PdppaSQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC-TFITTQMPLPTTVSDFWSMVFDFKPSTI
|. .||. |.    |    |.|  |    |  |||| | ||... || |    |    ||||| |. | .   || || ||| |..||| ||.. .   |
kikeefrlleesvgp....setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcrii

VMLNDKGQS-DKSCAQYWPNDD-----------SAKFGSYSVSILSTSSDG--DVTTRQLKVTRNSKAsHTVTQYQFHGWPKHGS-DQQPGARSLMKLIR
|||. . .     | .|||..               ||.||| ..    |   .. ||....| . .. . .||||. ||| |   |.    | |.. | 
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsit

AVK--SSTNKKKEFSILVHCLSGSGRTGVFCTAMEC
  .     .  ..  |.||| .| |||| ||||.  
nrqnqiipssdrnvpiivhcsagvgrtgtfctavim
0049260 (Phosphotyrosine protein) phosphatases II 403-551 8.2e-33 108.6 In-house 2-143 (152) alignment 
Range on Protein: 403-551
Range on HMM: 2-143/152.0
IPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRTVtQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGV
|. . . ...|| |||   ...|||||... ..||| |.|.| | .|   ..   |.... ||| |||...  || ... ..    .  .| ..||||||
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGv

GRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
||||... .. .       . |.....|  .|.||| .|....|. |.|
gRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 444-593 8.3e-33 108.9 In-house 169-323 (325) alignment 
Range on Protein: 444-593
Range on HMM: 169-323/325.0
LKEGDKGdDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTH------PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKR
.|. .|| . |.| ||..  |.| ||.|. ..|. ... ||| . . |       |...||||||||||| ||. |..|.  .   ||.|.|| ..|..|
vkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdr

PFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEF
| ||.| .|| .|| |. | ..  || .||  |  .|  |.       . .. |||
psmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekef
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 453-556 1.2e-32 108.0 In-house 135-238 (239) alignment 
Range on Protein: 453-556
Range on HMM: 135-238/239.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
 | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... .||  . ||.||.|  ||. ||.|||| ||| ||. 
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

AVLE
||||
avle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 453-556 1.8e-32 107.4 In-house 136-239 (239) alignment 
Range on Protein: 453-556
Range on HMM: 136-239/239.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
 | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... .||  . ||.||.|  ||. ||.|||| ||| ||. 
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

AVLE
||||
avle
0051082 (Phosphotyrosine protein) phosphatases II 393-554 3.4e-32 106.5 In-house 1-149 (151) alignment 
Range on Protein: 393-554
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdndkaYIASQGPniasMDDFWRMVWQENVTTIAMVTKLKEGDKGDDY-----RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdh
|.|||.|.||. ..     ...|.||    ..||..........|| ......| ..  .|     ..|...... ||| |.| .. ..|.|.... .  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld..

gQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrmVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAV
 .  .|...|||||.||||... .. .  .      |...  .  .|.||| .||. .|. |.. |.
.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 616-847 3.4e-32 106.5 In-house 35-273 (285) alignment 
Range on Protein: 616-847
Range on HMM: 35-273/285.0
NQPKNRYGNNLPLERNRVILDSSDHDYINASYMKG---VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPND--DSAKFGSY
|   ||| .   .|  ||.|   |.||| ||.|.     . |.|||| ||| |.|||| |... | . ..||    .   . || |.|.   .  ||| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVSILSTSSDGDVTT--RQLKVTRNSKASHT---VTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNkkKEFSILVHCLSGSGRTGVFCTAMECIAQI
 ...     .    |    | |.    ||     . . |   || . . .   || ...| . ||      ||  | ||| .| |||  |     .  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlape..darpmielykwvkkvnp..kekpicvhcsagvgrtatfvgidyatiri

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
 |   ..... |. .|| |.| ||.  .. | | |. ||.  |
menpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 452-556 5.4e-32 105.9 In-house 131-237 (237) alignment 
Range on Protein: 452-556
Range on HMM: 131-237/237.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV--KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
. | . |..|| |||.|||..|..||.| |..  .. | . . | ||||||||||||... ||... .||  ..||..|.| .| . ||...||..|| |
evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvf

IYGAVLE
|. ..||
ihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 616-838 5.5e-32 105.8 In-house 7-234 (239) alignment 
Range on Protein: 616-838
Range on HMM: 7-234/239.0
NQPKNRYGNNLPLERNRVILDS----SDHDYINASYMK---GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPnDDSAKFG
|. |||| | .  ...||.|.        |||||||..   |   ..|.||  . ..  ||| |... .   ||||    .   | | |||| | ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

SYSVSILSTSSDGDVTTRQLKVTRNSKAS-HTVTQYQFHGWPKHGSDQQpgARSLMKLIRAV-KSSTNKKKEFsiLVHCLSGSGRTGVFCTAMECIAQIA
   |..  |    |   | . ...  ..  . | ||.|  || .|  |   | ... | | . | |    . .  ..|| .| |||| |      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqak

EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYE
.  .||||. || .| || ..||| |.| | . 
kqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 616-838 5.7e-32 105.8 In-house 8-235 (239) alignment 
Range on Protein: 616-838
Range on HMM: 8-235/239.0
NQPKNRYGNNLPLERNRVILDS----SDHDYINASYMK---GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPnDDSAKFG
|. |||| | .  ...||.|.        |||||||..   |   ..|.||  . ..  ||| |... .   ||||    .   | | |||| | ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

SYSVSILSTSSDGDVTTRQLKVTRNSKAS-HTVTQYQFHGWPKHGSDQQpgARSLMKLIRAV-KSSTNKKKEFsiLVHCLSGSGRTGVFCTAMECIAQIA
   |..  |    |   | . ...  ..  . | ||.|  || .|  |   | ... | | . | |    . .  ..|| .| |||| |      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqak

EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYE
.  .||||. || .| || ..||| |.| | . 
kqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_PTPN6_pd Subfamily PTPN6 448-555 1.2e-31 104.8 In-house 180-294 (306) alignment 
Range on Protein: 448-555
Range on HMM: 180-294/306.0
DKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT----HPLIIHCSAGVGRTGVVISIDSVVAHAKT---TRMVDVFNFVTNIRQKRPFM
.|... |.| |.||..|||.||||... .|.|...|.. . ...     |...|||||.|||| .| || ..   ..      .|. ..|  .|. |  .
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

VQTQEQYAFIYGAVL
|||..|| |.| |. 
vqteqqykfvykaik
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 358-449 1.6e-31 104.7 In-house 47-138 (298) alignment 
Range on Protein: 358-449
Range on HMM: 47-138/298.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
 ..||.|. | ||||| .|...||.|| || .|.  .||| |||.. .... .|.||.|.|  ... ||||||..|...|| |.|.|.| ||
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldk
DSPc_SM00195 358-448 1.4e-30 101.9 In-house 17-107 (263) alignment 
Range on Protein: 358-448
Range on HMM: 17-107/263.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
. | |.|. | .|||||||||||. ||||. ... ..||| ||.||   ...|.||| |||    ..|||||||.|.|..|.|.|. .| .
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng
PTPc_SM00194 358-448 1.4e-30 101.9 In-house 17-107 (263) alignment 
Range on Protein: 358-448
Range on HMM: 17-107/263.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
. | |.|. | .|||||||||||. ||||. ... ..||| ||.||   ...|.||| |||    ..|||||||.|.|..|.|.|. .| .
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng
0036282 (Phosphotyrosine protein) phosphatases II 640-838 2.2e-30 101.0 In-house 2-164 (174) alignment 
Range on Protein: 640-838
Range on HMM: 2-164/174.0
HDYINASYMKGVHCT--FITTQMPLPttvsdFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNddsakfgsysvsilstssdgdvttrqlkvtRNSKAS
.||||||.......|  .| .| ||.     || |..... .|.|||..  . .   | .|||                               . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HTVTQYQFHGWPKHGSDQQPGarsLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAeGDSVDIFQTVKILRADRMQFVQTEEEYAFT
... ||.. .|| ||    .    | .....|..  .....  .||||  | ||||... |. .. ..   . ||....|. ||  |.. |||.. | | 
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YE
|.
yy
subfamily_Ptp69D_pd Subfamily Ptp69D 333-449 3.3e-30 100.3 In-house 11-130 (307) alignment 
Range on Protein: 333-449
Range on HMM: 11-130/307.0
AFIENNRHS--ALFSGEFHDLPGPDIYPQT-VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRM
  ......    ..  |.. |.   |  .| |..|. |. ||||..| ..|. ||||..|    .||| |||.| .... | .||.|.|  | ..|||||
ealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRm

VWQENVTTIAMVTKLKEGDK
... .||.| |...|.| ..
iaeqevtlivmlsnlteknr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 445-572 5.6e-30 99.1 In-house 165-293 (439) alignment 
Range on Protein: 445-572
Range on HMM: 165-293/439.0
KEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-ADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQT
.| |...  ||| |||.. |||| || ..| .|.|.. .. |.  . . |...|||||||||| .|..|  . . |.   ||.   |. .|..|  |||.
nerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqa

QEQYAFIYGAVLEDLLWRNTLIPVVHFTD
  || ||| |||||. . .. . . .|  
lcqyvfiynavledivyGdiavtidefkk
0044763 (Phosphotyrosine protein) phosphatases II 378-553 6.1e-30 99.6 In-house 1-166 (178) alignment 
Range on Protein: 378-553
Range on HMM: 1-166/178.0
PYDSARVKLEVIDDIPHSDYFNASYIPSFdndkAYIASQGPniasmDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRTV-----TQFHFTEWPDKGVPKH
|.|  ||.|. . ... |||.|||.|  .     |..|..|      |..........|.| ..|. .|. . ....        |.... .|| |||  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdl

TSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttRMvDVFNFVTNIRQKRPfMVQTQEQYAFIYGA
.. .|.|.. ... . .  .| ..||||||||.|... .. .  .    .. .... .  .|..|| .|....|. ..|  
lehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyef
subfamily_PTPRG_pd Subfamily PTPRG 343-449 1.1e-29 98.0 In-house 20-130 (563) alignment 
Range on Protein: 343-449
Range on HMM: 20-130/563.0
LFSGEFHDLP---GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHS-DYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
 || ||..|     ..  . . .||. | .|||| ||..||..||||. . .. .. || ||.||  .   ||.||.|||    .||||||.|..||..|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTKLKEGDK
 |.|.|.|  .
vmitnlvergr
subfamily_PTPN12_pd Subfamily PTPN12 356-449 1.4e-29 97.9 In-house 29-122 (290) alignment 
Range on Protein: 356-449
Range on HMM: 29-122/290.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|......|| | ||||||.||||| .||.|. |.. ..||| ||..|   .....|||.|||  . .||||||.|. ||. . |. .. | .|
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 453-555 2.1e-29 97.5 In-house 160-265 (274) alignment 
Range on Protein: 453-555
Range on HMM: 160-265/274.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHP---LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
 |.|. . .|.|||. .|.....||....||. .. . ...    ..|||||.||||. |.|.  | . . . .|||.. |.|.|..|  ||||.||| .
ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyel

IYGAVL
|. |. 
ihralc
subfamily_PTPN13_pd Subfamily PTPN13 452-558 3e-29 97.1 In-house 164-269 (273) alignment 
Range on Protein: 452-558
Range on HMM: 164-269/273.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. | |....|..||| |||... .||.|..||.  .   . |...|||||.||.|..|.|| |.   .  . .|| . | ..|..|  .|||..|| |.|
esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvy

GAVLEDL
 |.|| |
kailevl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 344-448 4.4e-29 96.5 In-house 17-122 (281) alignment 
Range on Protein: 344-448
Range on HMM: 17-122/281.0
FSGEFHDLPGPDIYPQTV-AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVT
|  |...|   ..   .. .... | .||||.||  || .|||..  ..  ..|| ||...|.....|.|||.|||  ||...||.|||...|..|.|||
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

KLKEGD
.  |..
reieag
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 360-449 6.5e-29 95.9 In-house 2-91 (250) alignment 
Range on Protein: 360-449
Range on HMM: 2-91/250.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.||.|  |..|||| .|...||.|| ||  .   .||| |||.. ..|. ||.||.|||  |.. ||||||..|...|| |.|.||| .|
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesek
subfamily_PTPN3_pd Subfamily PTPN3 452-556 9.7e-29 95.2 In-house 169-273 (280) alignment 
Range on Protein: 452-556
Range on HMM: 169-273/280.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. |...|. ...|||.|||......|.|...|.. .   ..|...|||||.|||||.| ..  .|   ... | . . | ..|..|  .|||..|| |. 
eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC

GAVLE
 |.|.
eailk
0046846 (Phosphotyrosine protein) phosphatases II 632-844 9.9e-29 95.7 In-house 4-173 (176) alignment 
Range on Protein: 632-844
Range on HMM: 4-173/176.0
RVILDSSDHDYINASYMKGvhCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDSAKFgsysvsilstssdgdvttrqlkvt
|.. .  | |||||... |  . .|.|| ||| |. ||. |... . ...|.|..  . .. .|..|||   ....                        
rllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

rnskashtvtQYQFHGWPKHGSDQQpgaRSLMKLIRAVKSSTNKKkeFSILVHCLSGSGRTGVFCTAMeciaQIAEGDSVDIFQTVKILRADRM-QFVQT
          ||....|| ||  .    . |..|......  ...    .||||  | ||||... |      .  .  ........ .|. |. . |||
..........qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

EEEYAFTYEVIREYL
.| | | ||.....|
peQyrflyefellll
Y_phosphatase Protein-tyrosine phosphatase 367-449 1.5e-28 95.2 Pfam-A 1-83 (235) alignment 
Range on Protein: 367-449
Range on HMM: 1-83/235.0
NLKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD--K
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.|||   ...|||||||||.|..|.|.|.|.| .  |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrek
Y_phosphatase Protein-tyrosine phosphatase 367-449 1.5e-28 95.2 In-house 1-83 (235) alignment 
Range on Protein: 367-449
Range on HMM: 1-83/235.0
NLKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD--K
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.|||   ...|||||||||.|..|.|.|.|.| .  |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrek
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 452-556 1.5e-28 94.5 In-house 150-262 (270) alignment 
Range on Protein: 452-556
Range on HMM: 150-262/270.0
DYRTVTQFHFTEWPDKGVPKHTS------SLLKFIKEVKADHGQFTH--PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQT
. | .. |....|||.|||...       .||| ...|.. . .. .  ||..||||||||||..| .| .|   ..|. ||| . ....|..|. .||.
eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqh

QEQYAFIYGAVLE
 |||.|.| ||.|
peqyeflykavve
0043147 (Phosphotyrosine protein) phosphatases II 638-838 2.9e-28 94.1 In-house 3-155 (172) alignment 
Range on Protein: 638-838
Range on HMM: 3-155/172.0
SDHDYINASYMKGVHCT--FITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKgqsdkscaqywpnddsakfgsysvsilstssdgdvttrqlkVTRNSKA
...|||||||.......  || || ||. |..||| |. . . ..||.|..                                          ..  .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

SHTVTQYQFHGWPKHGSDqqpGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAF
.... ||....|| ||      .. |..... ...  .....  .||||  | ||||... |  ..       .......|. .|. |.. ||... | |
erlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

TYE
 |.
lyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 584-852 6.3e-28 92.7 In-house 13-288 (307) alignment 
Range on Protein: 584-852
Range on HMM: 13-288/307.0
RGRSKMTKEFQTLKSLCPDPPASQTRSGrtpdNQPKNRYGNNLPLERNRVILD--SSDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPS
.| .... ||. |    |.  . .. |     |. |||| .    ...|...       ||| | |.        || .| || .|. .||.|. . |  
kgvqalvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

TIVMLNDKGQSDK-SCAQYWPNDDSAK--FGSYS----VSILS---TSSDGD-VTTRQLKVTRnSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAV
...|| .  .  |  | |||| ..  |  ||. .    |. |     . | | .   .|||   .. | |....|.. || .|  |     . . |. ||
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqi..nltainlleav

KSSTNkkkefSILVHCLSGSGRTGVFCTAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREY---LHTENYEQL
.  ||      ..||| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| . . |. ||   |. | ||.|
rydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
subfamily_PTPN9_pd Subfamily PTPN9 451-556 1.2e-27 91.7 In-house 170-288 (297) alignment 
Range on Protein: 451-556
Range on HMM: 170-288/297.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT-------------HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKR
.. |.|| | |. ||| |||. ..|||.....|.   ....              |...|||||.||||  |..|  ... ... .|||.. |  .|..|
eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqr

PFMVQTQEQYAFIYGAVLE
 |..||.|||.| | ||||
afsiqtpeqyefcylavle
PTPc_DSPc_SM00012 738-841 1.4e-27 91.3 In-house 1-104 (105) alignment 
Range on Protein: 738-841
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||  ...   |...|.||||...||...  ...|||  | ||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

TYEVIR
 |... 
lyrall
subfamily_PTPN6_pd Subfamily PTPN6 345-447 1.6e-27 91.3 In-house 29-135 (306) alignment 
Range on Protein: 345-447
Range on HMM: 29-135/306.0
SGEFHDLP---GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIP--SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIA
. ||..|      . . .. ..|  | .|||||||||.| .||.|.  ...| ||| ||.||   . ..||.|||.||   . . |||||||||| . | 
eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrviv

MVTKLKEG
|.||  | 
mttkevEr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 354-443 2e-27 91.4 In-house 48-137 (319) alignment 
Range on Protein: 354-443
Range on HMM: 48-137/319.0
PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
..   || |  . |  |||. |||..| ..|||| .. .  ||| |||..  . . . |||.|||   ...|||||.|. |..|| ..||
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltk
subfamily_PTPRN_pd Subfamily PTPRN 451-557 2e-27 90.7 In-house 184-291 (297) alignment 
Range on Protein: 451-557
Range on HMM: 184-291/297.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAH-AKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
.. ||||||||  ||..|||  . |||.| . |   .   . |...|||.|.||||| | || |... .|  . .|.   .  .|..|| .|.|..|. |
setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef

IYGAVLED
...|| |.
altavaee
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 358-443 3.7e-27 90.6 In-house 16-101 (284) alignment 
Range on Protein: 358-443
Range on HMM: 16-101/284.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
 || |  . |  |||. .||..| ..|||| .. .  ||| |||.|  . . . |||.|||   ...|||||.|. |..|| ..||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltk
subfamily_PTPRK_pd Subfamily PTPRK 360-446 4e-27 89.9 In-house 36-122 (314) alignment 
Range on Protein: 360-446
Range on HMM: 36-122/314.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 .|.|. | .|||...||.|| .||.| .||. |.||| ||..| |. . .|.|. |||    . ||||.|..|| ..| |.|.|.|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelve
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 450-559 4.1e-27 89.9 In-house 169-279 (287) alignment 
Range on Protein: 450-559
Range on HMM: 169-279/287.0
GDDYRTVTQFHFTEWPDKG-VPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
 .| ..|.|...|.|...| |... ..|| . . .|... .   ....|||..|||... ....  . ..||   .|||. . . |...| .||| ||| 
agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqyk

FIYGAVLEDLL
||. .||| | 
findivleyld
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 343-449 6e-27 89.6 In-house 24-130 (325) alignment 
Range on Protein: 343-449
Range on HMM: 24-130/325.0
LFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMV--WQenVTTIAM
 |. ||  ||  |   ..|| |  | .|||.||....| .|| ||  .| |.|||.||||. .. . . ..|.| |. |...|.||.|  |.   . . .
gfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvv

VTKLKEGDK
. .|..|..
lneldlgkd
subfamily_PTPN9_pd Subfamily PTPN9 361-449 8e-27 89.0 In-house 36-124 (297) alignment 
Range on Protein: 361-449
Range on HMM: 36-124/297.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
....  ||.||||...| ||..||.|. .|. ..||| ||...  . . ||.|| |||    ..|||||||...| .| |.|.. |  .
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 445-557 1e-26 88.5 In-house 169-282 (290) alignment 
Range on Protein: 445-557
Range on HMM: 169-282/290.0
KEGDKGDDYRTVTQFHFTEWPDKG-VPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQT
|. ..... ..|||...| |...| |......|| . . .|  . .  .....|||..|||..| ....  . ..||.  .|||. . . |...| .|||
knknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqt

QEQYAFIYGAVLED
..|| .|.  ||. 
vqqyqgifqivlty
subfamily_PTPN23_pd Subfamily PTPN23 451-557 2.1e-26 87.4 In-house 168-279 (288) alignment 
Range on Protein: 451-557
Range on HMM: 168-279/288.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA----DHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPFMVQTQE
|  ..|.  ..|.||. |||.  ..||.|..||..     . .   ||..|||||||||||.  . ..|.   |   ..|. . |  .|..| ||||..|
davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

QYAFIYGAVLED
|. | | |||| 
qlkfsyeavlea
0051082 (Phosphotyrosine protein) phosphatases II 640-840 6.7e-26 86.1 In-house 3-149 (151) alignment 
Range on Protein: 640-840
Range on HMM: 3-149/151.0
HDYINASYMKGVhctFITTQMPLPttvsDFWSMVFDFKPSTIVMLNDKGQSDkSCAQYWPNDDsakfgsysvsilstssdgdvttrqlkvtrnskasHTV
 ||||.||. |    .. ...||.    ||. .. . . .|||.|...   .  |..|.|. .                                  ..|
sdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................iev

TQYQFHGWPKHGSDQQ-PGARSLMKLIRAvksstnkKKEFSILVHCLSGSGRTGVFCTAMECIAQiaegdsVDIFQTVKILRADRMQFVQTEEEYAFTYE
.......|| .| ..  . ......|...       ||.  .|||| .| ||||... .. .. .      |....... .|. |. .||..... | . 
lhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

VI
..
al
subfamily_CG7180_pd Subfamily CG7180 452-559 7.6e-26 85.4 In-house 178-291 (296) alignment 
Range on Protein: 452-559
Range on HMM: 178-291/296.0
DYRTVTQFHFTEWPD-KGVPKHTSSLLKFIKEVKADHGQF-----THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQE
. |.|..|..|||.  . ||  |..|..... |.   ..      . |.....| |..|.|| ..||  .  .. .  ||||..|  .|..|| .|.. |
etRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenve

QYAFIYGAVLEDLL
.| .||  .|| .|
eYkyiYdvlleavl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 325-449 8.6e-26 85.8 In-house 3-128 (305) alignment 
Range on Protein: 325-449
Range on HMM: 3-128/305.0
PIPVAQFPAFIENNRHSA--LFSGEFHDLPGPdIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIAS
.| .... |.|...|      .  ... |.     .  | .|| | .|||.|.| ..|  |..|   .. ..||| ||||. .... |.||..|||    
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MDDFWRMVWQENVTTIAMVTKLKEGDK
..||||....| |.|| |.|||.||.|
vadfWrliveekvstivmltklveggk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 362-449 2.3e-25 84.1 In-house 3-91 (239) alignment 
Range on Protein: 362-449
Range on HMM: 3-91/239.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
|.| .|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||   .|  |||||.|||    | |.| | || |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 649-833 2.8e-25 83.7 In-house 86-270 (301) alignment 
Range on Protein: 649-833
Range on HMM: 86-270/301.0
KGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPNDDS--AKFGSYSVSILSTSS--DGDVTTRQLKVTRNSK--ASHTVTQ
.|    ||.|| ||. |  ||| |.  ..  .||||  |  .  . |..| | . |   . | ... | .. .  . ... |.|.|.  ..  |..||| 
sGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvth

YQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNkkkefSILVHCLSGSGRTGVFCtAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEY
||.. |...|  .  .   |..|.  || | .      |.||| .| ||.  |  . |..|.  | |  ... ...| || .| . |||..  
yqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 362-449 3.2e-25 83.7 In-house 2-90 (239) alignment 
Range on Protein: 362-449
Range on HMM: 2-90/239.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
|.| .|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||   .|  |||||.|||    | |.| | || |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 361-449 5.5e-25 82.9 In-house 14-103 (270) alignment 
Range on Protein: 361-449
Range on HMM: 14-103/270.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFD-NDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
. .   . | |||..|||   .||.|| ... ... |.|| |.. || ..|.|||..||  ... .||||.|.|.||.|.|.|.|.|  .
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 585-849 1.5e-24 81.2 In-house 22-293 (305) alignment 
Range on Protein: 585-849
Range on HMM: 22-293/305.0
GRSKMTKEFQTL-KSLCPDPPASQTRSGRTPD-NQPKNRYGNNLPLERNRVILDS-SDHDYINASYMKGV---HCTFITTQMPLPTTVSDFWSMVFDFKP
|  |. .||. | |   ||       . ...| .. |||| .    ... | ||  |  ||| | |.      .  || .| ||  |. .|| || . | 
gvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

STIVMLNDKGQSDK-SCAQYWPNDDSAKFGSYSVS---ILSTS----SDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKS
  ||||    .  |  ||||||     |    |      .| |     | ..    |..| . . . .| . |.  ||  |    |   . ..|. |.. 
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv..ppckltslellsairg

StnkkkEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHtENY
|     .  |.||| .| ||||   .    . .|||  ..  . . || || .|   .|.. .| | . |. .|.  |.|
s.....kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 612-846 2.3e-24 80.7 In-house 44-289 (305) alignment 
Range on Protein: 612-846
Range on HMM: 44-289/305.0
RTPDNQPKNRYGNNLPLERNRVILDSS-DHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVML-NDKGQSDKSCAQYWPNDDSA---
.  ... |||| .   |..||| |...  |.|| | |.        || || ||  | .||| | .. |  .| || | . .  | |..|.. .|     
keaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

----------KFGSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSStnkKKefSILVHCLSGSGRTGVF
          || | .   . .... .||  .| .    . .. ||.| .  ||  |        ....|.   ..|   |    | ||| .| ||||  
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarps...kg..pivvhcsagigrtgsv

CTAMECIAQIAEGDSVDIFQ-TVKILRADRMQFVQTEEEYAFTYEVIREYLHT
      . |. .|. ..  .  .. .| .| . .||...| | ..|| .|.. 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 342-449 2.4e-24 80.7 In-house 9-114 (283) alignment 
Range on Protein: 342-449
Range on HMM: 9-114/283.0
ALFSGEFHDLPGPDIyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIP---SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
 ||   .. |  ||  . ..|  . | .|||...|.|.|  ||.|.        || ||..||   | ..|| ||..|.|    . |||.||..|..|.|
klfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

AMVTKLKEGDK
 |.|||.|. .
vmltklqedlr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 361-449 2.7e-24 80.6 In-house 27-115 (297) alignment 
Range on Protein: 361-449
Range on HMM: 27-115/297.0
VAQKEINLKKNRYKNILPYDSARVKLEviDDIPHSDYFNASYI--PSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|...  |.||||..|| .|..||||     |. .|| || |.  |  ..|  || .|||  |..||||..|....| .|.||.||.|. .
sakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr
0049260 (Phosphotyrosine protein) phosphatases II 652-838 4.1e-24 80.4 In-house 8-144 (152) alignment 
Range on Protein: 652-838
Range on HMM: 8-144/152.0
HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWpnddsakfgsysvsilstssdgdvttrqlkvtrnskashtvtQYQFHGWPKH
.  || || |.| |..||| |. . . .|||||..    .|  |.||.                                          ||... || |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GSDQQPGARSLMKLIRAVKsstNKKKEFSILVHCLSGSGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFTYE
|  . .     . |.       ...|.  .||||  | ||||... |  ..        |.....|. .|. |.. |.... . | ||
gvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 346-449 4.2e-24 80.1 In-house 9-112 (274) alignment 
Range on Protein: 346-449
Range on HMM: 9-112/274.0
GEFHDLPGPDiyPQTVAQKEINLKKNRYKNILPYDSARVKLEVID-DIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
 || .||     .|   .   . .|||||.||| . .|| ||  . . . |.| || ||  .|. .|||.| ||| .  ..|||||..||.|. | |.||
keflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LKEGDK
||| ..
lkeane
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 362-446 4.2e-24 79.8 In-house 33-116 (287) alignment 
Range on Protein: 362-446
Range on HMM: 33-116/287.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDiPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
|..  . ||||| ..||.| .|| |    .   ||| || |..|. .|.|.||.|||  |.. ||||.|...........|.  |
aeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreve
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 620-840 7e-24 79.5 In-house 23-255 (290) alignment 
Range on Protein: 620-840
Range on HMM: 23-255/290.0
NRYGNNLpLERNRVILDSS----DHDYINASYMKGV-HCTFITTQMPLPT-------TVSDFWSMVFDFKPSTIVMLNDKGQSDK-----SCAQYWPN--
.|. . | .| .||.|         ||| |....      .| || |.         |. .|| |. . |   .||| .  . ..     .||.| |.  
qRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv

DDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKhgSDQQPGARSLMKLIRAVKsstnkKKEFSILVHCLSGSGRTGVFCTAMEC
... ||.  .|.  |   . || ||.| |. . .  .||| ....|| |  .  |.  ..|..||. ||     ...  ..|||  |  |  .. .    
geelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnk..lnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilg

IAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
   ||   .|| . . .| ||  | . .....|.||   .|
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_PTPN14_pd Subfamily PTPN14 452-556 7.6e-24 79.2 In-house 181-294 (300) alignment 
Range on Protein: 452-556
Range on HMM: 181-294/300.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF---------THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQ
..|||  . .|.|||.|||.  .. |....||..   ..           |...|||||||||||.|  | ..|  .. . .|. . .. .|..| ..||
eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvq

TQEQYAFIYGAVLE
|  || |.| ....
tlaqYkfvYkvlik
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 327-450 8.8e-24 79.0 In-house 3-126 (287) alignment 
Range on Protein: 327-450
Range on HMM: 3-126/287.0
PVAQFPAFIENNRH--SALFSGEFHDLPG----PDIYpqTVAQKEINLKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDNDKAYIASQGPNI
|| .|  |......  .  |.  |  |      .|    |..  . | .|||...||..|  || |.      | || ||..| .. ..||.|....| .
pvekfgefvakghakgnegfknqftvleqvtqredev..thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmf

ASMDDFWRMVWQENVTTIAMVTKLKEGDKG
  . .||......|||.| |....|| |. 
ntarnfWkliddrnvtaivmlcqekendee
subfamily_PTPN1_pd Subfamily PTPN1 449-557 2.5e-23 77.2 In-house 157-270 (290) alignment 
Range on Protein: 449-557
Range on HMM: 157-270/290.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhGQF---THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPFMVQ
| .. |....||.| ||| |||.  ...|||. .|.   | .     | .||||||.||.| .. .|..... . .     ||. . . ..|. |  ..|
ktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

TQEQYAFIYGAVLED
|..|  | | |.|| 
tadqlrfsylaileG
subfamily_CG7180_pd Subfamily CG7180 337-445 3.3e-23 76.8 In-house 12-120 (296) alignment 
Range on Protein: 337-445
Range on HMM: 12-120/296.0
NNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVT
 ... ... .|..  |  .|     . .. |..|||. ...||| .|| || .|   .||| ||.|. ||  .|.||  ..|   ..|.|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIAMVTKLK
.. ..||  
avvvLtktf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 454-557 3.4e-23 76.8 In-house 188-292 (301) alignment 
Range on Protein: 454-557
Range on HMM: 188-292/301.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-ADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
..|.|.. |.||. || .     |. | .|  . .     |...|||..|.|.|| .|..  .  .|    ||||. .  .|...| .|.| ||| .|| 
wdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd

AVLED
.. . 
vidmy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 616-851 5.4e-23 76.4 In-house 43-278 (288) alignment 
Range on Protein: 616-851
Range on HMM: 43-278/288.0
NQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPND--DSAKFGSYS
|  ..|| |    .  || |.   . ||.|  .   .    .| .| || .|.  .| |...     ||||..  .   .  |.|.|    ..|..| . 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VSILSTSSDGD--VTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNkkkefSILVHCLSGSGRTGVFCTAMECIAQIAEGD
  .    .| |  |.   |..... . .  | .  .. |...|  ..    | ..|.  .|| ..      |.||.  |.|||| .   .  . ..   |
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrldd

SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYEQ
 . | . .. ||..|.. .|||  | . . .. |.|    |..
flgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 326-449 5.5e-23 76.2 In-house 2-130 (290) alignment 
Range on Protein: 326-449
Range on HMM: 2-130/290.0
IPVAQFPAFIENNRH--SALFSGEFHDLP-GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPH--SDYFNASYIPSFDNDKAYIASQGPNI
||| .|  |..|..      |  .|. |  |   .  ||.  . | ..||..||..||  |. |  | . .    .| ||.||  . ..|.||| |||  
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASMDDFWRMVWQENVTTIAMVTKLKEGDK
  . |||...|||.|| | |.|. .| .|
ntlvdFWkliwqekvtiivmltniieegk
0048076 (Phosphotyrosine protein) phosphatases II 427-554 6.1e-23 76.5 In-house 22-139 (145) alignment 
Range on Protein: 427-554
Range on HMM: 22-139/145.0
WRMVWQENVTTIAMVTKLKEGDKgddyRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDSVVAhakttRMVDV
... .. ..||.  .|  .|. .    |...|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||... .. .       . |..
lellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

FNFVTNIRQKRPFMVQTQEQYAFIYGAV
.. .  .|..||..|....|. |.| ..
eealelvrsqrpgavpnpgqlrflyefe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 359-446 1.4e-22 74.8 In-house 40-127 (439) alignment 
Range on Protein: 359-446
Range on HMM: 40-127/439.0
QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 ..| .| .  |||||.. ..| .|| |. |  .||| |.|| ||  . .|| |||.|||.  . |||||.|......|| |.|.| |
aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 456-569 1.6e-22 74.7 In-house 164-277 (283) alignment 
Range on Protein: 456-569
Range on HMM: 164-277/283.0
VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVL
.. . . .| . |      ||.|| | .     .   |...|||.|.|||.| |.. . | .|.|  .||||. |...|..|. .|||..|| ... .||
lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

EDLLWRNTLIPVVH
|. |  .| |  | 
eqalcgdtqiaavd
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 654-839 3.1e-22 73.7 In-house 5-198 (198) alignment 
Range on Protein: 654-839
Range on HMM: 5-198/198.0
TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDS--AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS---HTVTQYQFHGW
 .|.|| ||  |..||| ||..     |||.||  .  .   . |||  .|  .|.|| ||.  . ..  | |   | .| |. |      ...|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
 .. . .      ..   | |    ...|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | | |.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_PTPN13_pd Subfamily PTPN13 360-449 3.3e-22 74.0 In-house 30-116 (273) alignment 
Range on Protein: 360-449
Range on HMM: 30-116/273.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsdYFNASYIP--SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|..|. | .||||.|.|||| .||||.         | |||.|     ..   |||.|||   ...|||.|||. ... |||||. ||..|
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 654-839 3.3e-22 73.6 In-house 6-199 (199) alignment 
Range on Protein: 654-839
Range on HMM: 6-199/199.0
TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDS--AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS---HTVTQYQFHGW
 .|.|| ||  |..||| ||..     |||.||  .  .   . |||  .|  .|.|| ||.  . ..  | |   | .| |. |      ...|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
 .. . .      ..   | |    ...|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | | |.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_PTPN3_pd Subfamily PTPN3 360-447 3.6e-22 73.6 In-house 34-121 (280) alignment 
Range on Protein: 360-447
Range on HMM: 34-121/280.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDdipHsDYFNASY----IPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEG
..|.|  ||.||||..|||||..||||.  .     || ||.|    ||| .  . |||.|||   .. |||.|||......| |.| | | 
saarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver
subfamily_PTPN14_pd Subfamily PTPN14 361-449 4.4e-22 73.4 In-house 43-132 (300) alignment 
Range on Protein: 361-449
Range on HMM: 43-132/300.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIpHSDYFNASYIPS--FDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|. . | .|||.|..|||. .||.|    .  ...| ||| |      ... ||..|||    . |||.|||...|. |.|.|. .|. |
taklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk
0048179 (Phosphotyrosine protein) phosphatases II 429-551 9.8e-22 72.7 In-house 24-138 (144) alignment 
Range on Protein: 429-551
Range on HMM: 24-138/144.0
MVWQENVTTIAMVTKlkEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDSVVahakTTRmVDVFN
. .. ..||.  .|   | .. .  |...|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||... .. ..    . . .....
llkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lslee

FVTNIRQKRPFMVQTQEQYAFIY
 .  .|..||..|....|. |..
alalvrsrrpgavpnpgqlrfLl
subfamily_PTPN23_pd Subfamily PTPN23 361-450 1.3e-21 71.7 In-house 37-123 (288) alignment 
Range on Protein: 361-450
Range on HMM: 37-123/288.0
VAQKEINLKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDND-KAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKG
.|  ... .|||...|||||..||||.      . || |||.. .       .||.|.|   .. |||.||... . .| |... .| .| 
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 338-450 1.5e-21 71.4 In-house 11-125 (301) alignment 
Range on Protein: 338-450
Range on HMM: 11-125/301.0
NRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVID--DIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENV
. ||  |. ....|   .  . ||  .| | . ||.||| .||  |. |.     |. . .| ||||| .. . |..||.|||    . ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLKEGDKG
..| |||.|||| | 
vsivmvtnlkegtks
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 367-449 2.1e-21 71.3 In-house 3-84 (237) alignment 
Range on Protein: 367-449
Range on HMM: 3-84/237.0
NLKKNRYKNILPYDSARVKLEVIDDIphSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
|  |||| ||  || .|| |.       ||| ||.|. .||   | |||.|||  .| ||||.|||||. . | |.| | ||..
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegne
subfamily_PTPRN_pd Subfamily PTPRN 359-448 4.5e-21 69.8 In-house 48-138 (297) alignment 
Range on Protein: 359-448
Range on HMM: 48-138/297.0
QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
..||..| |.||||.|..|||| .||||.   .  .||| ||| |   |    ||||.|||  ... |||.|||.. |. | ..|.|.| .
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 344-448 5.5e-21 69.4 In-house 13-119 (281) alignment 
Range on Protein: 344-448
Range on HMM: 13-119/281.0
FSGEFHDLPG-PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEV-IDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMV
|  || .||| |     || .. .| ||||| ||   | .||.|.| . .   .||  | || |    . || .|||.  .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLKEGD
 .. | .
cqfletn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 594-843 6.2e-21 69.3 In-house 15-268 (281) alignment 
Range on Protein: 594-843
Range on HMM: 15-268/281.0
QTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND
| .  |  |||.        | |. |||| |   |.  || |          ||| | |..    .  .| || |   | .||| |... . ..|||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

KGQSD-KSCAQYWPNDDS--AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKaSHTVTQYQFHGWPKHgsdQQPGAR-SLMKLIRAVKSSTNkkkefSILV
  ... . ||.|.| .     .|  .|||   .. .  . | .|... . . .. .|.. .. ||     | |..   ..|..| ... .        ..
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege.trlithwlwkewpdw...qvpessevmlkilrkirarst.....ppvi

HCLSGSGRTGVFCTAMECIAQIAE-GDSVDIFQTVKILRA-DRMQFVQTEEEYAFTYEVIREY
|| .| ||.| . .   ..  |       || | |  ||   |   ||| ..| . ..|. ..
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_egg_pd Subfamily egg 636-842 1.9e-20 67.8 In-house 68-268 (307) alignment 
Range on Protein: 636-842
Range on HMM: 68-268/307.0
DssdhDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSdKSCAQYWPN--DDSAKF--GSYSVSILSTSSDGD--VTTRQL
|    |.| | ..||  .  .|| .| ||  || ||| |||  .   ||||. . .| . |  |||.  .||...  ||. .  |   |  |   .  .|
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

KVTRNSKASHTVTQYQFHgWPKHGSDQQPgarslMKLIRAVKSSTNkkkefSILVHCLSGSGRTGVFCTAMECIAQIAEGDS--VDIFQTVKILRADRMQ
|.    .    .  .|   . . .    |     ....| ..  ..      ..|..  |  ..... ..   . ..  |      . ..|. ||  |  
klvGgddeerflehwqgd.vnnssdvysp.....lrvlrklrnlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

FVQTEEEYAFTYEVIRE
 |..   | | | ..  
svesvllylfvyrlvlf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 447-559 2e-20 68.1 In-house 169-278 (307) alignment 
Range on Protein: 447-559
Range on HMM: 169-278/307.0
GDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPFMVQTQE
 | ... ||.... ...|||.|||.   . . ... |. |    | |...||||||||.| ...|  |     .     |. ..| ..|..|.. .||. 
vdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqtea

QYAFIYGAVLEDLL
|| ...  .|| .|
qylylhrvlleyfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 610-752 2.3e-20 67.7 In-house 27-179 (297) alignment 
Range on Protein: 610-752
Range on HMM: 27-179/297.0
SGRTPDNQPKNRYGNNLPLERNRVILDS--SDHDYINASYMK----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDD
| . .    |||| . |  . .|| |    ...||||| |.          .| .| || .|| ||| .|..    .|||.    .   . || |||. .
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

S--AKFGSYSVSILSTSSDG--DVTTRQLKVTRNsKASHTVTQYQFHGWPKHGS
    | |.. |  ||. ||    |   .|..    . |  |.  || .|| || 
qerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 618-848 3.9e-20 66.8 In-house 45-280 (312) alignment 
Range on Protein: 618-848
Range on HMM: 45-280/312.0
PKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPN-------DDSAKFG
  ||| |    .| |  |   .  || | ..| .     |..|| ||  |.. || ... .  ..|..|     .. . ||.|  .       .|   . 
dlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

SYSVSI-LSTSSDGDVTTRQLKVTRNSK-ASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKsstN-KKkefSILVHCLSGSGRTGVFCTAMECIAQI
 |   | .   |   .| | |||  ..      . .||.  || ||  .     . ..|. |||   . ||    .. || .| |||| ..     || .
eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds..cdtalrllsavk...kdkk...pviahcsagvgrtgtlaliesmiaal

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
      .. ..  .|| || . |..  .| ..  .. |.|... 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 665-846 4.2e-20 66.9 In-house 40-223 (255) alignment 
Range on Protein: 665-846
Range on HMM: 40-223/255.0
TVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN---SKASHTVTQYQFHGWPKHGSDQQpgARS
||  |. ..   |....||| |  . . . | .|.| .   |     |.. .| |  ||  | |..| .    |  |||. |...||... . ..  || 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel..are

LMKLIRAVKSStnKkkefSILVHCLSGSGRTGVFCTAmECIAQ-----IAE--GDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
.......|. |  |    |..||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|  . ||.  .. .... 
ilnilkvvrds..k....svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfp
subfamily_PTPN1_pd Subfamily PTPN1 357-446 8.3e-20 65.7 In-house 22-107 (290) alignment 
Range on Protein: 357-446
Range on HMM: 22-107/290.0
YPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
.|...|... | ..|||... ||| .|.|||  |     || ||| .   . .. || .|||    .| ||.|||...  .. |. |. |
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 449-556 1.6e-19 64.8 In-house 181-285 (305) alignment 
Range on Protein: 449-556
Range on HMM: 181-285/305.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDV-FNFVTNIRQKRPFMVQTQEQY
 | . | ||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |. .. ..    . ....     .  ||..|   .||..||
pgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqy

AFIYGAVLE
 |..  .|.
lfvhqviln
subfamily_CG42327_pd Subfamily CG42327 613-771 1.9e-19 64.5 In-house 25-193 (319) alignment 
Range on Protein: 613-771
Range on HMM: 25-193/319.0
TPDNQPKNRYGNNLPLERNRVILDSS----DHDYINASYMKGV---HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPND---
 .  ..|.|. | .||   ||.|..        |..|||..|    .. .|..|..|  . |||| .|.. .  .|| | |  .   | ||.|.|     
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

-DSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-SKASHTVTQYQFhGWPKHGSDQQPGArsLMKLIRAVKSS
 .   .| . |..    ..    .  | . |   . |  .| | .  |.. .   .. |  |. ..  |.||
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaa..liamllevrss
0044763 (Phosphotyrosine protein) phosphatases II 627-844 3.6e-19 64.5 In-house 1-171 (178) alignment 
Range on Protein: 627-844
Range on HMM: 1-171/178.0
PLERNRVILDSSDH----DYINASYMKGVhcTFITTQMPlpttvSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDSakfgsysvsilstssdgd
||.|.||.|..  .    ||||||.. .    ..... |     .|.. .. . . ..||.|..       .| .||| . .                  
pldrtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

vttrqlkvtrnskashtvTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQiaegdSVDIFQTVKILRA
                   ||.. ..| ||  .    . ..........  . .|.  .||||  | ||.|... |  .. .     ...... .. .|.
..................iqylhipipDhgvpd..llehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

DRMqFVQTEEEYAFTYEVIREYL
 |. .|.... . . ||. ...|
rRp.ivpnpgqlrqLyefelrll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 616-846 5.7e-19 62.6 In-house 51-287 (302) alignment 
Range on Protein: 616-846
Range on HMM: 51-287/302.0
NQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVHC--TFITTQMPLPTTV---SDFWSMVFDFKPSTIVMLNDKGQSDKSCAQYWP--NDDSAKFGS
|  ||.  .   |. |.|.|. .  .|.||| ..  ..  . | .|.|  ...    .|| |||. |  ..|.|  . . .|.  ...|   .|  ..|.
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygk

YSVSILSTSSDGDVT-TRQLKVTRNSKA-SHTVTQYQFHGWPKHGSDQQPGarSLMKLIRAVkSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAE
  | .   ..  . .    . |  .  . |  .. | .. |...   .. .  .|.| .  |    . | . ....    |.|| |.| |..  . .. .
mfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya..eliktaakv.fakkikadentvivSknGaGRagafltlavaveklqk

GDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
|. . | ..|| .|..| . |.. . |...| ..  |. .
gkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 615-853 8.3e-19 62.3 In-house 46-288 (303) alignment 
Range on Protein: 615-853
Range on HMM: 46-288/303.0
DNQPKNRYGNNLPLERNRVILdsSDHDYINASYMK-GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQY-W-PNDDSAKFGSYSV
.|  |||. . . |.  .| |  ||  || |||..   .   | ||.||. | .||| |. . |   ...|   .. ||   .. .  |.|  ||   |.
knmdknrfvdvicldhskvkl..sdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersi

SILSTSSDGDVTTRQLKVTRNSKASH--TVTQYQFHGWPkHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILV-HCLSGSGRTGVFCTAM-ECIAQIAEG
 .        .   .|||   |. ..   .  .... || |.|    |.  ..| |  ..|   |  . .  |   ||| ||.| |.      ..  .| 
rvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq

DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYEQLP
 |.|. . .. .|  |.. ||   .... | .. |..  . . .| 
asldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 441-561 9.9e-19 62.4 In-house 158-274 (288) alignment 
Range on Protein: 441-561
Range on HMM: 158-274/288.0
VTKLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVkadhGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFM
|. |.   .|..   | . |. ||.|.|||.   | |.... .     ....|...|.|||||||| .| |  ..  .. .  . . ..... |..|   
vsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfka

VQTQEQYAFIYGAVLEDLLWR
.||. || ...  |||.|| .
iqtemqylyvhrcvleelllk
subfamily_eak_pd Subfamily eak 608-848 1.1e-18 61.7 In-house 44-309 (332) alignment 
Range on Protein: 608-848
Range on HMM: 44-309/332.0
TRSGRTPDNQPKNRYGnNLPLERNRVILDSSDH---DYINASYMK--GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPND
 . ..  ..  .| ..  .| .|. | | ||      ||||| ..   |   .| | ..  . |  || ||.. |  .||.| .. . . .   .|.|..
isetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

D--SAKFGSYSVSILSTSSDGDVTTRQLKVTRnSKASHTVTQYQFHGWPKHGS------------DQQPGARSLMKLIRAVKSSTNKKK-----EFSILV
     ||| . |   .    . . ||.|....    .| |  |...|| .                .. |.  |.    |. ||| ||       |. ..
treelkfGildverkefvkrniletrllelsk.GnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii

HCLSGSGRTGVFCTAMECIaQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 .  || |.|||      | .. ..    .  . . .   .  |.  | .. ...| ||.. .|| . |
qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_hpo-7_pd Subfamily hpo-7 663-841 2.7e-18 60.8 In-house 44-224 (263) alignment 
Range on Protein: 663-841
Range on HMM: 44-224/263.0
PTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR---NSKASHTVTQYQFHGWPKHGSDQQpgA
  |.  |....   |....||| |      . | .|.| .   |     |.. .| .  ||  . |...    . |  |||..|.. ||...   ..  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel..a

RSLMKLIRAVKSStnKkkefSILVHCLSGSGRTGVFCTAmECIAQ-----IAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIR
|. ........ |  |    |. ||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|    ||.  .. 
reilnilkvarns..k....slvvhcstGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 616-839 4.3e-18 59.9 In-house 52-285 (310) alignment 
Range on Protein: 616-839
Range on HMM: 52-285/310.0
NQPKNRYGNNLPLERNRVIL--D-SSDHDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDS-AKFGS
.  |||| . . |.  || |  | |  .||| | |.|   .  ||| .| ||  |. ||| |.|. .  .|..|   |.  .  |  |||       .| 
ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

YSVSILSTSSDGdVTTRQLKVTR-------NS-KA---SHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSStnkkkefSILVHCLSGSGRTGVFCTA
  |. || ||.      .| ||        .   |      |.  ..  ||  |  ..       .|.  |.           .||| .| .|..| .. 
irvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg.......pcvvhcsagkdrlyvvval

MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
   | .. .|. ||. . .  |. .|.. .||| .| .   |
klkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_ptpA1_pd Subfamily ptpA1 362-446 7.4e-18 59.5 In-house 42-125 (418) alignment 
Range on Protein: 362-446
Range on HMM: 42-125/418.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSfDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 .|. |  |||| |||| . .||.|. |.|   ||| || ||      | .|..|||   .. |||||||.. .  | |...  |
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsrese
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 483-553 9.8e-18 59.1 In-house 184-254 (267) alignment 
Range on Protein: 483-553
Range on HMM: 184-254/267.0
VKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGA
 | .  .  .||...||.||||.|  . ||| .  |||  ..|.|.|. .||..|. .|.|.|.| .|.  
aknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 480-558 1.6e-17 58.4 In-house 218-295 (297) alignment 
Range on Protein: 480-558
Range on HMM: 218-295/297.0
IKEVKADHGQfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
.. ..|.. .   .|..||||||||.|||.  | ..|  .  |. ||  ... .|..|. .||| ||. ..| |||. |
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 443-559 2.5e-17 57.5 In-house 177-290 (305) alignment 
Range on Protein: 443-559
Range on HMM: 177-290/305.0
KLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAH-AKTTRMVDVFNFVTNIRQKRPFMV
 |.    ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. .. . |.  .   . ..|  .|..| | .
llnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsi

QTQEQYAFIYGAVLEDLL
|.. || ||.  .|. .|
qndvqylfihrvmlnyfl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 450-555 4e-17 56.9 In-house 164-274 (287) alignment 
Range on Protein: 450-555
Range on HMM: 164-274/287.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV-----KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQ
. . | | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|.....  .|   . .  ||| . |  .|..|  .||. 
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

EQYAFIYGAVL
 |. ..| |. 
vqlrllyealv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 369-448 3.2e-16 54.0 In-house 49-142 (350) alignment 
Range on Protein: 369-448
Range on HMM: 49-142/350.0
KKNRYKNILPYDSARVKLE----VIDDIPH----SDYFNASYIP------SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
 ||||||||||. .||||.      | . |    .|| ||.|.       . . |  ||| |.|    .|||.... . .|. | ..|.. | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_CG42327_pd Subfamily CG42327 490-553 3.2e-16 53.9 In-house 246-310 (319) alignment 
Range on Protein: 490-553
Range on HMM: 246-310/319.0
FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGA
   ||..||| ||||||.||. |  . . ... | ||. . |  .|. |   |.|.|||.|||  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 618-702 4.1e-16 53.6 In-house 49-154 (350) alignment 
Range on Protein: 618-702
Range on HMM: 49-154/350.0
PKNRYGNNLPLERNRVILD------------SSDHDYINASYMKGV------HCTF--ITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQ
 |||| | || |..||.|              |  |||||.|.|           |  | || ||| || ||. ...  |   |..|..   .  . | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNDD
||.. .
YWqegs
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 495-558 5.1e-16 52.8 In-house 2-65 (69) alignment 
Range on Protein: 495-558
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 457-559 5.5e-16 53.2 In-house 179-277 (312) alignment 
Range on Protein: 457-559
Range on HMM: 179-277/312.0
TQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
 .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.|..|  .  |  .| .    .|. |   |..  || .   .|||
nhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle

DLL
 | 
fly
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 495-558 1.3e-15 51.5 In-house 1-64 (69) alignment 
Range on Protein: 495-558
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 323-406 2e-15 51.1 In-house 3-86 (440) alignment 
Range on Protein: 323-406
Range on HMM: 3-86/440.0
RQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSF
..|| ||.|  ...||| |  |  |.  ||     |  .|    |  ||||.||| || .|| || .  .|.||| ||||| . 
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 454-557 2.2e-15 50.9 In-house 188-287 (302) alignment 
Range on Protein: 454-557
Range on HMM: 188-287/302.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGA
.||  ..|. |||.| ||.. . |. .|  ..    . . ...|||||||||| ...|   .   .. .. |. . |. .|| |   ||...|  ..   
ktvdilafsawpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc

VLED
|   
vtkg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 553-752 4e-15 50.1 In-house 34-235 (244) alignment 
Range on Protein: 553-752
Range on HMM: 34-235/244.0
AVLEDLLWRNTLIPVVHFTDHlQDLHSSGDGRGRSKMTKEF-QTLKS-LCPDPpaSQTRSGRTPDNQPKNRYGNNLPLERNRVILD--SSDHDYINASYM
|||     .|  | .. | .  . . ||    |   .  .. |  .. . |||  |  .    |.|  ||| |  ||.. ||| |   |    |||||..
avlsanatknryinilpfdet.rvilssskkegsdyinanyiqgsqniirpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv

K--GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDkscaQYWPNDDSAKFGSYSVSILSTSSDG--DVTTRQLKVTRNSKASHT-VTQYQ
   |  . .| || ||  |  ||| |... .   .|.|    . |    .|||. .  ..    ...  |  |   .. . .|..  . . ||  .| .|
gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfq

FHGWPKHGS
   ||  |.
isnwpsdgt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 367-446 4.5e-15 50.0 In-house 52-130 (310) alignment 
Range on Protein: 367-446
Range on HMM: 52-130/310.0
NLKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
...|||| ...  |..||||. ||   . ||  | |. .    ...| ||||   .. |||||..||   .| .. |  |
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvge
0048076 (Phosphotyrosine protein) phosphatases II 733-843 9.2e-15 50.1 In-house 41-142 (145) alignment 
Range on Protein: 733-843
Range on HMM: 41-142/145.0
SKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKkeFSILVHCLSGSGRTGVFCTAMECIAqiaegDSVDIFQTVKILRADRMQFVQTEEE
.  .....||.. .|| ||  . .  . |.........  ...    .||||  | ||||... |. ..       .|....... .|. |...|.... 
ellerlgiqylylpwpDhgvpdll..ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YAFTYEVIREY
. | ||...|.
lrflyefelel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 455-555 2.9e-14 47.4 In-house 184-280 (290) alignment 
Range on Protein: 455-555
Range on HMM: 184-280/290.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAV
 .  ..   |||| |.. | .||. .. ..   |    |...|||||.||||  ..|.  .      . .|. . |  .|. |   || . ||  .  ..
klkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

L
|
l
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 660-834 2.9e-14 47.2 In-house 98-278 (302) alignment 
Range on Protein: 660-834
Range on HMM: 98-278/302.0
MPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPND--DSAKFGSYSVSILSTSSDGDVTTRQ-------LKVT---RNSKASHTVTQYQFHG
.|   |.  .|... ... . .| | . . . .| ||.|. ..  .  ||| |.|  .|   | .  | .       ....   ...|  .||   .| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPKHGSDQQPgaRSLMKLIRAVKSStnKKkefSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
||.||. ...   . .....  .|   ||   ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   
wpdhGapkea..ytaldilkfcesy..kk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 453-553 5.2e-14 46.7 In-house 180-277 (301) alignment 
Range on Protein: 453-553
Range on HMM: 180-277/301.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI-Y
 |||| . ..||.|.||||    | .... ||  .    .|...|||||.||.   |. . .  . .. . ... . . ..|..|   |||..|  ..  
trtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtl

GA
|.
Gt
subfamily_egg_pd Subfamily egg 360-453 7.9e-14 46.0 In-house 33-126 (307) alignment 
Range on Protein: 360-453
Range on HMM: 33-126/307.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKGDDY
| | .. ||.| | | .   ||.|||||.       |.  | ..        .| .| |   ..|||||||.||.|  | |.|  || .. . |
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyy
0048179 (Phosphotyrosine protein) phosphatases II 736-838 8.7e-14 46.9 In-house 46-139 (144) alignment 
Range on Protein: 736-838
Range on HMM: 46-139/144.0
SHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNkkKEFSILVHCLSGSGRTGVFCTAMECIaqiAEGdsVDIFQTVKILRADRMQFVQTEEEYAF
 ....||.. .|| ||  . .    | ........  .  ..  .||||  | ||||....|  ..    .|  ........ .|. |.. |.... . |
eregiqylhlpwpDhgvpdll..ellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgavpnpgqlrf

TYE
 .|
Lle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 456-555 1.2e-13 45.5 In-house 217-341 (350) alignment 
Range on Protein: 456-555
Range on HMM: 217-341/350.0
VTQFHFTEWPDKGVPKHTSSLLKFIK-------EVK-ADHG--QFTHPLIIHCSAGVGRTGVVISIDSVVA-------------HAK-TTRMVD-VFNFV
| |...  |.| ..  .  |.|. ..       .     |   . . |...||||||||||.....||..              . . .... | ..  |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

TNIRQKRPFMVQTQEQYAFIYGAVL
 ..|..|  |||. .|. ||| |.|
nelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 453-555 1.4e-13 45.2 In-house 166-266 (281) alignment 
Range on Protein: 453-555
Range on HMM: 166-266/281.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHAKT-TRMVDVFNFVTNIRQ-KRPFMVQTQEQYAFI
 | .|.. . ||||  ||. .  .|| .....|     . | .|||||||||.| .....  .   ..   . |. . |. .|   |   ||| .|| .|
trlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymli

YGAVL
.  .|
wkvll
subfamily_CG42327_pd Subfamily CG42327 753-843 1.7e-13 45.0 In-house 222-314 (319) alignment 
Range on Protein: 753-843
Range on HMM: 222-314/319.0
DQQPGARSLMKLIRAVKSST-NKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREY
  . |. |  ..   . | . ....   . |||  | ||||.  ..   | .. |   |||| |.|  .| || . |.| | |.| | |. ||
kaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 367-446 2.9e-13 44.2 In-house 48-124 (305) alignment 
Range on Protein: 367-446
Range on HMM: 48-124/305.0
NLKKNRYKNILPYDSARVKLEviDDIPHsDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
. .|||||..   |  |||||     || .|  | |. .  | | .| .| |   .  ||| | .|..| .| |. .|.|
eagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnlle
subfamily_CG42327_pd Subfamily CG42327 346-446 3.5e-13 43.9 In-house 9-108 (319) alignment 
Range on Protein: 346-446
Range on HMM: 9-108/319.0
GEFHDLPgpDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDND-KAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKL
 ||.|||   .  .. .      .|.|. |..|   .|| |. | | ... |..|||.  .|.    |||.| .   |  ||||.||. .  .|  .|.|
eefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

KE
 |
se
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 361-448 6.7e-13 42.9 In-house 50-132 (290) alignment 
Range on Protein: 361-448
Range on HMM: 50-132/290.0
VAQKEINLKKNRYKNILPYDSARVkleVIDDIPHSDYFNASYIPSFdnDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
. .|. ..||||||..   | .||   ...|  . ||  | |.     .  .| .||.  ... |.|||| ||.|..| |. .| |  
ifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedG
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 360-446 1.4e-12 42.3 In-house 34-118 (307) alignment 
Range on Protein: 360-446
Range on HMM: 34-118/307.0
TVAQKEINLKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
||   . | .||||...   | .|. ...  |   |||  | |.    . | .|..|||  ... .|| |. ||.| .. |. |. |
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvie
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 367-447 5.5e-12 40.3 In-house 33-109 (267) alignment 
Range on Protein: 367-447
Range on HMM: 33-109/267.0
NLKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEG
| ..||. . |||| .|| |   .     .| ||||. ..   .|.|. |.|   .. ||. .. ...|..| ..||  ..
nqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 342-417 6.7e-12 39.4 In-house 23-95 (95) alignment 
Range on Protein: 342-417
Range on HMM: 23-95/95.0
ALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphSDYFNASYIPSFDNDKAYIASQG
  |  ||. ..     | ||   | |. |||. ||.|||..|| |    |   ||| || ..  .   ..|||.||
qefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 460-555 8.1e-12 39.2 In-house 187-282 (302) alignment 
Range on Protein: 460-555
Range on HMM: 187-282/302.0
HFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVL
..| |..| ||.. ..| | ...| | . . .....|    |.|| |....   .| . ..   . . . |..||..|| .|.. .||...| |.|
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 782-844 8.6e-12 39.2 In-house 2-64 (69) alignment 
Range on Protein: 782-844
Range on HMM: 2-64/69.0
VHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| | .. . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 781-844 1.1e-11 39.0 In-house 2-65 (69) alignment 
Range on Protein: 781-844
Range on HMM: 2-65/69.0
LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || | .. . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 461-558 1.4e-11 39.0 In-house 174-270 (285) alignment 
Range on Protein: 461-558
Range on HMM: 174-270/285.0
FTEWPDKGVPKHTSSLLKFIKEVKADHGQfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
   |||.  |. .  .... | ||    .  .|. .|||||||||  .. ||    .      ..... | ..|  |   ||.. |. |.|  ..| .
vpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 364-446 2.2e-11 37.9 In-house 52-132 (305) alignment 
Range on Protein: 364-446
Range on HMM: 52-132/305.0
KEINLKKNRYKNILPYDSARVKLeviDDIPHSDYFNASYIPS-FDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 .|.  ||||...   | . |||   |. . |||  | |.   .  .| .|..|||   ..|.|| || |..|  | |. |  |
adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktve
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 454-551 3.8e-11 37.5 In-house 95-197 (199) alignment 
Range on Protein: 454-551
Range on HMM: 95-197/199.0
RTVTQFHFTEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPFMVQTQEQY
| .... || | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..|
reishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

AFIY
 |||
nfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 454-551 3.8e-11 37.6 In-house 94-196 (198) alignment 
Range on Protein: 454-551
Range on HMM: 94-196/198.0
RTVTQFHFTEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPFMVQTQEQY
| .... || | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..|
reishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

AFIY
 |||
nfiy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-551 5e-11 36.7 In-house 192-283 (310) alignment 
Range on Protein: 456-551
Range on HMM: 192-283/310.0
VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
|.  .. .|||.|||      .      .  ||    | ..|||||..|..||....  . ...    ||. . .|.....|   .||. || .| 
vslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 454-565 3.4e-10 34.5 In-house 158-257 (290) alignment 
Range on Protein: 454-565
Range on HMM: 158-257/290.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVVAH-AKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
 |||   . .| .  |...| .||. |. |||     . | |.||  |. |  .. .|.      |.|.  | . . . ..|..|  ........||.  
ftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

AVLedllwrntlI
...         .
giv.........l
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 659-844 3.9e-10 32.9 In-house 124-309 (346) alignment 
Range on Protein: 659-844
Range on HMM: 124-309/346.0
QMPLPTTVSDFWSMVFDFKPSTIV-MLNDKGqsDKSCAQYWPNDDSAKF---GSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHgSDQ
||   . | ||| |... .   .  |. |     |  .    ||.   .   |   .    .   ||     ..|  . ..   . | . |   ||  .|
qmenesfvedfwymiyqeqihlvylmvpddk..lkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkh.lqq

QPGARSLMKLIRAVKSStNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 | .  ..|.|   .|  .. ..  . |  | |.||.  |  |.  | |. .|   .|.. .| .. .|   |..  .||  | .. .|.
ppktlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 369-443 6.3e-10 32.9 In-house 50-140 (349) alignment 
Range on Protein: 369-443
Range on HMM: 50-140/349.0
KKNRYKNILPYDSARVKLEVIDD--------------IPHSDYFNASYI--PSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
 |||||.||||. .||||.                      || || |.  . .. .| ||| | |  ...|||....  ..|  .  ...
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnd
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 367-446 8.7e-10 33.1 In-house 43-118 (288) alignment 
Range on Protein: 367-446
Range on HMM: 43-118/288.0
NLKKNRYKNILPYDSARVKLEviDDiPHSdYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
|  ..||.|.   | .||||.  || |.  | .|  ..|  ...  | .| |  . .. .|.|. ...|  | |...| |
nptrdryenlprcditrvkls..dd.pdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcelle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 362-448 1.8e-09 32.0 In-house 30-113 (285) alignment 
Range on Protein: 362-448
Range on HMM: 30-113/285.0
AQKEINLKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFDND-KAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
.  | |   ||| ..   . .|| |.  |     ||  ||..    .|  .||..|||   .. |||.|..||... . |.  | || 
tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 774-840 1.9e-09 31.8 In-house 225-291 (297) alignment 
Range on Protein: 774-840
Range on HMM: 225-291/297.0
KKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
. ..  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. . |...
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 639-701 2.1e-09 31.2 In-house 89-156 (349) alignment 
Range on Protein: 639-701
Range on HMM: 89-156/349.0
DHDYINASYMK----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLN-DKGQSDKSCAQYWPND
 .||||| |.|     |.  .|.||.|||.|| ||. ..   .   .. || || .| . | .|| . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 454-558 2.3e-09 31.7 In-house 116-221 (255) alignment 
Range on Protein: 454-558
Range on HMM: 116-221/255.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA------HAKTTRMVDVFNFVTNIRQKRPFMVQTQEQY
.||. .... |..|  |. .  .|. .| |.       .....|||.|.||.   . ...|        .   |  .|  ......|.||.  ..|  | 
htvkhysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql

AFIYGAVLEDL
||    ||. .
afsilmvldlv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 737-844 2.3e-09 31.4 In-house 215-344 (350) alignment 
Range on Protein: 737-844
Range on HMM: 215-344/350.0
HTVTQYQFHGWPKHGSDQQPGA--RSLM---KLIRA--VKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIA------QIAEG---------DSVDIFQ
. | | |.. |.  .   .|    ..|    .||     .|  ....  .||||| .| ||||...|    .       .. .              |..
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

TVKILRADRMQFVQTEEEYAFTYEVIREYL
.|..||  |.. ||. . . | || .. | 
ivnelrkqrismvqnldqfifiYeallfyf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 626-752 2.7e-09 31.4 In-house 3-126 (130) alignment 
Range on Protein: 626-752
Range on HMM: 3-126/130.0
LPLERNRVIldssDHDYINASYMK--GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDkscaQYWPndDSAKFGSYSVSILSTSSDGD--
|. | .|.     ...|||||..   |    .. || ||  |  ||| |...     .|.|    . |    .|||  ||  .  |   |. |..| |  
lefevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywp..dsePlewyeediivtltdrdef

--VTTRQLKVTRNSKASH-TVTQYQFHGWPKHGS
  . . .|.. .. . || ..| .|   ||  |.
knikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 369-446 2.8e-09 31.1 In-house 52-126 (301) alignment 
Range on Protein: 369-446
Range on HMM: 52-126/301.0
KKNRYKNIlPYDSaRVKLEVIDDIPHSDyFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
.|.||... | .     .|||.|        | .||.  . . .||.|||  ....||| |. | .| .|.|...  |
dkhryptv.PckP.stavevivdGkrvP.ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 458-556 1.4e-08 28.5 In-house 222-342 (349) alignment 
Range on Protein: 458-556
Range on HMM: 222-342/349.0
QFHFTEWPDKGVPKHTSSLLKFIKeVKAD-----------HGQFTHPLIIHCSAGVGRTGVVISIDSVVA----HAK-------TTRMVDVFNFVTNIRQ
|. . .|.| ..     |.|. .. || |           . . . .|..||||| |||||.. .|....      .        . . |.  .. |. .
qlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelr

-KRPFMVQTQEQYAFIYGAVLE
 .|  |||   |. .|| |.|.
kqrismvqnlaqfiaiyealLk
subfamily_ptpA1_pd Subfamily ptpA1 452-510 1.5e-08 28.8 In-house 184-248 (418) alignment 
Range on Protein: 452-510
Range on HMM: 184-248/418.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF------THPLIIHCSAGVGRTGVVIS
. | .||...  |||. .| ||  . .... .   . |         |.|.|||||||||| . .
etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_eak_pd Subfamily eak 486-564 1.6e-08 28.4 In-house 231-311 (332) alignment 
Range on Protein: 486-564
Range on HMM: 231-311/332.0
DHGQFTHPLIIHCSAGVGRTGVVISIDSVVA--HAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTL
 |   ..  || .. |  |.|| . || ..    .| . .  | ...  ...||   | .. |..||| .||. || ||  
ihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
subfamily_PTPDC1_pd Subfamily PTPDC1 459-549 2.2e-08 28.7 In-house 85-167 (182) alignment 
Range on Protein: 459-549
Range on HMM: 85-167/182.0
FHFTEWPDKGVPKHTsSLLKFIKEVKADHGQFthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRmvdvfNFVTNIRQKRPFMVQTQEQYAF
..   |.| ||.  . ..|  .| |.    .    . .|| || |||||.|.   | |.  |.      . .. .|.|||  .||.||  .
vynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 360-444 2.8e-08 27.7 In-house 30-119 (347) alignment 
Range on Protein: 360-444
Range on HMM: 30-119/347.0
TVAQKEINLKKNRYKNILPYDSARVKLEV-----IDDIPHSDYFNASYIpSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKL
|... | .|.||| |.    |..|| |           .   | |||.|  ||| .| || .| |   .. |||.||   .|| .  . . 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
0038934 (Phosphotyrosine protein) phosphatases II 412-550 4.8e-08 28.4 In-house 20-169 (194) alignment 
Range on Protein: 412-550
Range on HMM: 20-169/194.0
YIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRT---------------VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF-THPLI
 ||  .|   |.|...  ... .....  . ||.  . |  ..                  ...   .||.|..  .. ||.|.. |.  . .   .   
fiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvva

IHCSAGVGRTGVVIsidsvVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.|| ||.||||...     .|.   ..  ..   .  .|.||| ....|...  .
VHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdyleal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 639-686 1.1e-07 25.8 In-house 69-118 (347) alignment 
Range on Protein: 639-686
Range on HMM: 69-118/347.0
DHDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND
 . |||||..|    .  .| || ||| || ||| ||.  | . .| . .
vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
fn3 Fibronectin type III domain 176-255 1.3e-07 24.8 Pfam-A 19-79 (85) alignment 
Range on Protein: 176-255
Range on HMM: 19-79/85.0
QWDPRSdTGDGPIVGYKIYVRSGRNVVlakevqppsmvnktdrsVSKRSAENATEMvMYNASGLEPGSTYSVQIAAIRDG
.|.| . .|.|||.||.. .|. ..                   ..|.    .|..  .. .||.||..|.....|. ..
sWsppk.dgggpitgYeveyrekggge.................ewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_egg_pd Subfamily egg 489-555 1.6e-07 25.3 In-house 199-267 (307) alignment 
Range on Protein: 489-555
Range on HMM: 199-267/307.0
QFTHPLIIHCSAGVGRTGVVISIDSVVAHAK--TTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVL
. ..| ....  || .......|.  . .     .    | . |  .|..|.. |..  .| |.|  ||
nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0038934 (Phosphotyrosine protein) phosphatases II 742-796 2e-07 26.4 In-house 80-134 (194) alignment 
Range on Protein: 742-796
Range on HMM: 80-134/194.0
YQFHGWPKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCT
.... .|  .    |    |.. ...|.  .|....  ..|||  | ||||... 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_hpo-7_pd Subfamily hpo-7 454-556 2.1e-07 25.1 In-house 122-225 (263) alignment 
Range on Protein: 454-556
Range on HMM: 122-225/263.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA----H--AKTTRMVDVFNFVTNIRQKRPFMVQTQEQY
.||... .. |..|  |. . . |. .| ..       ..|..|||.|.||.     ...|            |  .|  ......|..|.  ..|  | 
htvkhysykgWiekndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqL

AFIYGAVLE
||    ||.
afsilmvLd
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 356-448 2.2e-07 24.7 In-house 23-114 (332) alignment 
Range on Protein: 356-448
Range on HMM: 23-114/332.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDipHSDYFNASYIPSFDNDKAYIASQGPNIA-SMDDFWRMVWQENVTTIAMVTKLKEGD
 ||.|  .   |.  ||   .  .| .||.|   |   . |..|||..  . .  ||| .| |    .   ||||| . . . | ..  . | .
typntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 367-446 2.4e-07 24.5 In-house 51-129 (302) alignment 
Range on Protein: 367-446
Range on HMM: 51-129/302.0
NLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYI--PSFDndKAYIASQGPNIASM---DDFWRMVWQENVTTIAMVTKLKE
|||||. ...  .|| .||||   |    .| ||| .  |..   .  | .| |.  |    ..|||||.||..... .. . .|
nlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeee
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 567-651 9.7e-07 22.9 In-house 7-84 (95) alignment 
Range on Protein: 567-651
Range on HMM: 7-84/95.0
VVHFTDHLQDLHSSGDgrgrSKMTKEFQTLkslCPDPPASQTrSGRTPDNQPKNRYGNNLPLERNRVILDS-SDHDYINASYMKGV
|  |  |. ..||  |     .. .||...        |. |  | .  | ||||. | .| .  ||.| .  | ||||| .. | 
vsvfhshvlemhsnsd....qefdnefksi...smtsgapyt.vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 365-448 1.5e-06 22.0 In-house 94-175 (244) alignment 
Range on Protein: 365-448
Range on HMM: 94-175/244.0
EINLKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
  |  |||    ||.|  || |          | |||..  .     || .| |   .  |||.|. .  |  . ..  ..| |
pnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 732-844 1.8e-06 21.5 In-house 213-344 (349) alignment 
Range on Protein: 732-844
Range on HMM: 213-344/349.0
NSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIR-------AVKS--STNKKKEFSILVHCLSGSGRTGVFCTAMECIA--QIAEGDSVD---------
...  . . | |.  |.  .    |   |... .           .    ....  ..|||| .| |||||..|    ..  .  . .|.          
avekPyellqlqvknwldlslllnP..isilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

-IFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 |. .| .||  |.. ||   .. . || . .|.
lisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 366-441 3.2e-06 21.0 In-house 46-114 (303) alignment 
Range on Protein: 366-441
Range on HMM: 46-114/303.0
INLKKNRYKNILPYDSARVKLEviddipHSDYFNASYIpSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMV
 |..|||. ...  | ..|||        | |  |||.  .| .|  | .| |   .  |||.|. ...|  . ..
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlll
PTEN_1 428-510 5e-06 21.5 In-house 58-149 (196) alignment 
Range on Protein: 428-510
Range on HMM: 58-149/196.0
RMVWQENVTTIAMVTKLKEGDKG----DDYRTVTQFHFT----EWPDKGVPKhTSSLLKFIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVIS
... .     | .|  | |...     .| ..  . ...    ...| |.|   |.|....|...    .    .  ..|| ||.||.|.|. 
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
PTPc_motif_SM00404 727-797 5.5e-06 21.3 In-house 32-100 (140) alignment 
Range on Protein: 727-797
Range on HMM: 32-100/140.0
LKVTRNSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSStnKKKEFSILVHCLSGSGRTGVFCTA
..||.. ...    ..|.   | . ..... .. | |... ....  .||. ..||||  |  |.. ...|
invteevsltkensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliia
subfamily_PTPDC1_pd Subfamily PTPDC1 757-837 6.5e-06 20.7 In-house 94-169 (182) alignment 
Range on Protein: 757-837
Range on HMM: 94-169/182.0
GARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDsvdifQTVKILRADRMQFVQTEEEYAFTY
|..|| ...  ||  .   .|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .  
gvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 452-559 7.5e-06 19.8 In-house 168-280 (303) alignment 
Range on Protein: 452-559
Range on HMM: 168-280/303.0
DYRTV-TQFHFTEWPDKGVPKH-TSSLLKFIKEVKADHGQFT--HPLIIHCSAGVGRTGVVISIDSV--VAHAkTTRMVDVFNFVTNIRQKRPFMVQTQE
||..     |. .|| . .| . .. ..| | ....   ...  .| .    .|.||.|    ...     |.     .|. . . |.|. |   ||   
dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhs.eqasldlvkclenvrngrlhavqnls

QYAFIYGAVLEDLL
|....|  . | .|
qfsvvytllaehvl
subfamily_DSP10_pd Subfamily DSP10 467-534 9.3e-06 19.6 In-house 72-133 (159) alignment 
Range on Protein: 467-534
Range on HMM: 72-133/159.0
KGVPKHTSSLLKFIKEVKADHGQfthpLIIHCSAGVGRTgVVISIDSVVAHAKtTRMVDVFNFVTNIR
. . ..    |.||.|..    .    ...|| ||. |  . . |  ...| .   . | ..|| . |
qnlkqyfeealefieearkkgsr....vLvhCqaGisrs.atvviaYlmkhln.lslndaykfvkekr