Gene SpurPTP-sf1-6 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP083_AA protein Get Run
SpurP083_AA_589-864 phosphatase_domain Get Run
SpurP083_AA_876-1105 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 588-995 9.3e-261 860.3 In-house 1-411 (515) alignment 
Range on Protein: 588-995
Range on HMM: 1-411/515.0
PIPAAQFPAFVNKNRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMD
|.| |||||||||||||.|| |||||||||.||||||||.||| |||||||||||||.|||||||.| ||||||||||||||||.|||||||||| ||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKE
||||.|.|||||||||||||.||||||| .|||.| |||||||..|||| ||||||||.|||.|. ||||.|||||||||||||||||||||||||.|||
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVD
|||||||||||||||||||||||||||||||||||||.||||||||||||||.||||.|||.||||||||||||||||||||||||||||||||||.| |
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

GNGRSKMSKEFQSL---CPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKGVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIV
|.||||| ||||.|   |||||||||||| . |||||||||||.||.|||||||||.||||||| .||.|||||||||||||||||||||||. ||||||
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstiv

MLNDKSQNDKA
||||||||||.
mlndksqndks
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 587-901 4.1e-188 618.7 In-house 1-315 (315) alignment 
Range on Protein: 587-901
Range on HMM: 1-315/315.0
QPIPAAQFPAFVNKNRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASM
|||| |||||||||||||||| |||||||.||||.|.||...|| ||||||||||.||||||||||||.|.|||.|||||.|.|..|||||||||. ||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIK
|||||||.||.||||.||||.|||||||||||||....|||.||..|||| ||||.|.||.||...||... ||||||.|||||||||.|.||||||.||
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSV
|||||.|.....|..||||||||||||||||.|||..|.||.|||||||.|.|.||||.|||.|.|||||.|||||||||||||.|||||||||||||||
evkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsv

DGNGRSKMSKEFQSL
||.|||||.|||..|
dgsgrskmtkefetl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 586-901 1.2e-177 585.2 In-house 1-274 (392) alignment 
Range on Protein: 586-901
Range on HMM: 1-274/392.0
RQPIPAAQFPAFVNKNRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAAS
|||||.|||||||.||||.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||||||||||||||||||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVTTIAMVTKLQEGDkikcrqywpnkqgdsvkfgnfkvelesleactggvkrkmtmrKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFI
.|||||||.|||||||||||||.|||                                          ||||.|||.||||||||||.||||||||||||
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

KEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTS
||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||.||
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

VDGNGRSKMSKEFQSL
.||..|||..|||.||
sdGdvrskqlkefrsl
subfamily_PTPRD_pd Subfamily PTPRD 586-989 3.7e-142 469.8 In-house 2-415 (564) alignment 
Range on Protein: 586-989
Range on HMM: 2-415/564.0
RQPIPAAQFPAFVNKNR--HTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNA
..||| |.....|.| .  . . |.||....  ..  . ..|.|..| .||||.||..||. ||.|. ..  . ||| |||.| .....|||||.||| |
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKqGdSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSL
 ...|||||||..|..|| |.|||.| .| || .|||.| | . ..|...|.||. |  .  . |.....  | .. |.|.|||||.|||.|||... ||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQD
|..|..|.| . . ..|...||||||||||. | ||...  .|. ..||....|...|..|..||||.|||.||. |.|| |   || ... ....||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LHTSVDGNGRSKMSKEFQSLC--PDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILD----SPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWS
|.. ..... .....||| |    . ....  ..  | |. |||. | ..||..||.|.    . | |||||||... .   .|..|| ||  || ||| 
LaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwr

MVLKYKPSTIVMLNDK
|| ...  .||||.. 
mvweeevkiivmltkl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 585-876 3.5e-120 395.6 In-house 6-297 (297) alignment 
Range on Protein: 585-876
Range on HMM: 6-297/297.0
TRQPIPAAQFPAFVNKNRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNekAYIASQGPNAA
 |.||| ..|...|.||||| .| |||..||   |.|||||.| .|..|.|||||||||| ||||....| | |||.|||..... .   .|..| |. |
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

SMDDFWRMVWQENVTTIAMVTKLQEGDKiKCRQYWPNKQgdSVKFGNFKVELESLEACTGGVKRKMTMRKGD--DCRTVTQFHFTEWPDKGVPK--HTSS
...|||.||..|.|.||.|.....|.|| ||..||..|   ...||.  |.|.|.. ..|..||.....||.    | | |..|.||||| |..  ..||
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LLKFIKEVKADHGQYTH-PLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFT
|||.|.||. |..| .. ||..||.||||||||...||||||.||..  ||.|..|. .|..|||.|||||||.|.| |||| ||  .| |.. .|.
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_PTPRA_pd Subfamily PTPRA 598-898 4.2e-93 306.8 In-house 23-330 (330) alignment 
Range on Protein: 598-898
Range on HMM: 23-330/330.0
VNK--NRHTALFFEEFHDLPGPDIYP-QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVW
...     . || |||  ||  .|     .|.|| | .|||. |||||| .|| | |.. ...||| |||.|  . . . .||.||| . ...|||||.|
irirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

QENVTTIAMVTKLQEGDKIKCRQYWPNKqGdSVKFGNFKVELESLEACTGGVKRKMTMR-KGDDC-----RTVTQFHFTEWPDKGVPKHTSSLLKFIKEV
. . .|| |.|.|.| .. || ||||.. | .| .|| .||.|  . .     ||. .. ..| .     | |.||||| ||| ||| ..  .||..|.|
eqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkv

KADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVDG
|. . |.. |...||||||||||  | .|.|..  |  |.||||.|| ..| .|| ||||.||| ||| ..||  |. .| . |. .  ||| |.... |
kklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitg

NGRSKMSKEF
  .  . .||
tdkigleeef
0051299 (Phosphotyrosine protein) phosphatases II 599-861 1.5e-91 302.1 In-house 15-284 (288) alignment 
Range on Protein: 599-861
Range on HMM: 15-284/288.0
NK--NRHTALFFEEFHDLPGPD-IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQ
.|   .......|||..|.     .....|... ||.||||..|||||. |||| |.|....||| |||||. .......|| |||   ...|||||||.
lkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvwe

ENVTTIAMVTKLQEGDKIKCRQYWPNkqGDSVKFGNFKVELESLEACTGGVKRKMTMR------KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK
.||..| |.|||.| ...|| ||||.  |.|...|...|.| | | . . ..|.....      ... .||||.||.| ||| ||| ....||.|...|.
qnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

ADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
  . .  .| ..||||||||||..| .| .. . .|...|||...|  .|..||.|||| ||| |.| |.||
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 585-867 5.6e-91 300.4 In-house 22-303 (308) alignment 
Range on Protein: 585-867
Range on HMM: 22-303/308.0
TRQPIPAAQFPAFVNKNRHTALFFEEFHDLPGPDIYPQ-TVAQKEINLKKNRYKNILPYDSARVKLevidDiPHSDYFNASYIPSF--DNEKAYIASQGP
.  ...  ..  ...|   . |..|||..|.   .... .||... | .|||||.|||||. ||||    | ..||| ||||.. .  ......|| |||
sslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgP

NAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQG-DSVKFGNFKVELESLEACTGGVKRKMTMRK--GDDCRTVTQFHFTEWPDKGVPKHT
   ...|||||||..||..| |.|||.| ...|| ||||...| .|...|.|.|.| | | . . ..|......  ... ||||.||.| ||| ||| ..
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

SSLLKFIKEVKADHGQytHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRN
..||.|...|.  ...  .| ..||||||||||..| .| .. . .|...||||. |  .|..||.||||.||| |.| |.|| |... 
eilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 596-901 6.3e-91 300.2 In-house 10-314 (317) alignment 
Range on Protein: 596-901
Range on HMM: 10-314/317.0
AFVNKNRHtALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQ
 ...|. .  .. |||.||.  .... .||... | .||||..|||||. |||| ... ...||| ||||.. ..  ...|| |||   ...|||||||.
ldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

ENVTTIAMVTKLQEGDKIKCRQYWPNkqGDSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG
..||.| |.|.| | ...|| ||||.  |.....|.|.|.| | | . | . |....   .....||||.||.| ||| |||.....||.|...|..   
qgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

QYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVDGNGRSK
.  .|...||||||||||..| .. .. . .|.. |||.. |  .|..||..||| ||| |.| |.|| |....||.|. ..  .|. |.. . ... . 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvkl

MSKEFQSL
. ||.. |
kekelkll
subfamily_PTPRB_pd Subfamily PTPRB 586-861 2.9e-90 297.3 In-house 4-283 (293) alignment 
Range on Protein: 586-861
Range on HMM: 4-283/293.0
RQPIPAAQFPAFVNKNR--HTALFFEEFHDLPGP-DIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPN
 .|| . .| ..|.|..    . | ||...|        ...|....| .||||.|||||| .||||. ..| ..||| ||.||| .  .. .||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQgDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLL
  ..||||||||......| |.|.| |. |.|| .|||... ..| .|. ||.| . |  .  | |.....|....|.|.|.||| ||| |||..|..||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

KFIKEVKADH--GQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.|...|.  .   . ..|...||||||||||. |..| .. . ... .||.| .|...|..| ..|||..|| ||. .||.
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 604-882 5.7e-90 296.6 In-house 19-299 (318) alignment 
Range on Protein: 604-882
Range on HMM: 19-299/318.0
TALFFEEFHDL-PGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIA
. |..||.. | . ..   .. . ...| .|||| |||.||..||||. ... . ||| ||.||. . ..|||||.|.| .  ..|||||||. | ..| 
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MVTKLQEGDKIKCRQYWPNKQgdSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH-GQYTHPL
|.|...|  |.|. .|||.|.  | ..|. .|||..   ..  | |.....  . .. |.| |.|.|.|||.|||....|||.....|.. .  . ..|.
mltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

IIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDL
..||||||||||| | .|... ..|.  .||||..|...|..|. ||||..|| ||| ..|| |   .| .   ........|
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 604-899 1.5e-89 295.3 In-house 22-319 (319) alignment 
Range on Protein: 604-899
Range on HMM: 22-319/319.0
TALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAM
. |. .||..| ...    . |.||.| |||||.|||.|| .||.|  .|... ||| |||.| ........|| |.| .  ..|||||||.|.. .. |
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvm

VTKLQEGDKIKCRQYWPNKQgdSVKFGNFKVELESLEACTGGVKRKMTMRK-GDDC--RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD-HGQYTHPL
.|||.|  |.|...|||...   ...|.. |.||. |   . ..||....|  ..   |.|..|..|||||..||... |||...|...   ...   |.
ltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPi

IIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVDGNGRSKMSKEFQ
..||||||||||  | .| .. . |.  ..|||..| ..| .|. |||..||| ||| |.|| .   .| | | .. | |..|   | . | .....|||
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
0046845 (Phosphotyrosine protein) phosphatases II 608-869 1.4e-88 292.2 In-house 3-280 (284) alignment 
Range on Protein: 608-869
Range on HMM: 3-280/284.0
FEEFHDLPGPDI---YPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDD-IPHSDYFNASYIPSF-----DNEKAYIASQGPNAASMDDFWRMVWQENV
.|||. |.   .   .. .||... ||.|||||.|||||. |||| ..|. ...|||.||||.. .     ...|..|| |||   ...|||||||..||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TTIAMVTKLQEGDKIKCRQYWPNKqGDSVKFGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG--
..| |.|.| | ...|| ||||.. |.....|.|.|.| | | . . ..|......   ..  ||||.||.|.||| ||| ....||.|...|.  .   
rvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

QYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTR---MVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTL
 . .| ..||||||||||..| .| .  . .|..   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0036941 (Phosphotyrosine protein) phosphatases II 606-874 1.8e-86 285.4 In-house 14-288 (297) alignment 
Range on Protein: 606-874
Range on HMM: 14-288/297.0
LFFEE-FHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLeviDDiPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMV
|. .|  . ||   ... .||... ||.|||||.|||||. ||||   || ..|||.||||.. .| ....|| |||   ...|||||||..|||.| |.
lllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEA--CTGGVKRKMTMRK--GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHP
|.| | ...|| ||||...|.|...|.|.|.| | |   ... . |.... .  ... ||||.||.| ||| ||| ...|||.||..|.  . .    .|
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

LIIHCSAGVGRTGVVISIDSVVAHAK---KTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIH
 ..||||||||.|..| .| ..   .   |.. ||....|  .|..|| .||| ||| |.| |.|| |....| .|.. 
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 597-861 2.1e-86 285.1 In-house 4-270 (273) alignment 
Range on Protein: 597-861
Range on HMM: 4-270/273.0
FVNKNRHTALFFEEFHDLPGPD-IYPQTVAQKEINLKKNRYKNILPYDSARVKLevidDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQ
...|  ...|..|||..|.    ... .||... |..|||||.|||||. ||||    . ..||| ||||.. .. ....|| |||   ...|||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

ENVTTIAMVTKLQEGDKIKCRQYWPNKQGD-SVKFGNFKVELESLEACTGGVKRKMTMRK--GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH
.||..| |.|.|.| ...|| ||||...|. |...|.|.|.| | | . . ..|......   ...||||.||.|.||| ||| ...|||.||..|.  .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GQ--YTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
 .    .| ..||||||||||..| .| .. . .|...|||.. |  .|..||.|||| ||| |.| |.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 599-868 3.5e-86 284.1 In-house 21-295 (298) alignment 
Range on Protein: 599-868
Range on HMM: 21-295/298.0
NKNRHTALFFEEFHDLPGPDI----YPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVW
.|. . . . .||. |           ..||.|. | ||||| .|...||.|| || .|.  .||| |||.. ......|.||.|.|  ... ||||||.
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

QENVTTIAMVTKLQEGDKIKCRQYWPNKQgdSVKFGNFKVELESLEACTGGVKRKMTMRKG--DDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH
.|...|| |.|.|.| ||.|. .|||...  . ..|...|.| | |  .  ..||... |   .. |.| |.|||.|||||||....|.|.....|.| .
eedigtiVmltnleeldktkyhkywPdeg..ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasq

GQYT-HPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNT
 |   .|.|..|||||||.|  | ||||. ..|| ..||||. |  .|.||| .|||.|||.||| |||| |   |.
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 590-883 4e-86 283.9 In-house 5-303 (305) alignment 
Range on Protein: 590-883
Range on HMM: 5-303/305.0
PAAQFPAFVNKNRHTAL--FFEEFHDLPGPdIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMD
  ... |.....| .    . .... |.     .  | .|| | .|||.|.| ..|  |..|   .. ..||| ||||. .....|.||..|||    ..
alddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKGVPKHTSSLLKF
||||....| |.|| |.|||.||.| |||||||........||.|.|||.| .. .. ..||... .    .. |||.|...|.|||.|||. ..|||..
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

IKEVKADHGQYTH-PLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLH
||.|. |. .    ||..||||||||||| |..|  . ..||  .||||. . ..|.||..||||..|| |.. |. | .   .| | .  .. ... |.
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 605-860 4e-86 283.6 In-house 21-276 (288) alignment 
Range on Protein: 605-860
Range on HMM: 21-276/288.0
ALFFEEFHDLPG-PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAM
. | ||.. |.       .|....  | |||||.||||||  ||||.  .. . .|| ||||| . ...|.|||.|||.|....|||..|......||.|
tgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivm

VTKLQEGDKIKCRQYWPNKQgDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHC
.|.| ||.| || .|||... . ...|...|.| . .  .  |.||. . |  . ...||.... |||.|||. .  ||.... ||  . . | |.|.||
ltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC

SAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
||||||||. |..| .. . ... ..||...|...|..|. .|||..|| ||| ..|
saGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 586-880 1.4e-85 282.0 In-house 3-296 (315) alignment 
Range on Protein: 586-880
Range on HMM: 3-296/315.0
RQPIPAAQFPAFVNKNRHT--ALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNA
.||||  |. ..| ... .    | ...  .|| ...|  ||.|  | .|||| ||..|| .||.| ...  ||||| ||..|. .. .. |||.||||.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKqgdSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLK
||..||||.|..|....| |.|.| ||.| |. .|||.|    | .|.. | . | |  |    | ...  ||. |.| |.|.| ||| ||||.| .|..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmn

FIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQ
.|. ||  | .   ....||||||||||  |..|.|. .|.  ...||.||.|..|..|  |||. ||| ||| |.|| ..  .| |    . .. .
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
DSPc_SM00195 618-861 4.4e-85 280.5 In-house 16-260 (263) alignment 
Range on Protein: 618-861
Range on HMM: 16-260/263.0
DiyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQ
.  . | |.|. | .|||||||||||. ||||. ... ..||| ||.||   ...|.||| |||    ..|||||||.|.|..|.|.|. .| .|.|| .
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPNKQGDSVKFGNFKVELESLEACT-GGVKRKMTMRKGD--DCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVI
|||...|.. .||...|.| . | .    ..|.....| .  . |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||...
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfv

SIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.||... . ... .||.|. |...| .|| ||||.|||.||| |.||
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 618-861 4.4e-85 280.5 In-house 16-260 (263) alignment 
Range on Protein: 618-861
Range on HMM: 16-260/263.0
DiyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQ
.  . | |.|. | .|||||||||||. ||||. ... ..||| ||.||   ...|.||| |||    ..|||||||.|.|..|.|.|. .| .|.|| .
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPNKQGDSVKFGNFKVELESLEACT-GGVKRKMTMRKGD--DCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVI
|||...|.. .||...|.| . | .    ..|.....| .  . |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||...
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfv

SIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.||... . ... .||.|. |...| .|| ||||.|||.||| |.||
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPN12_pd Subfamily PTPN12 619-861 5.1e-85 279.9 In-house 29-275 (290) alignment 
Range on Protein: 619-861
Range on HMM: 29-275/290.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQY
.|......|| | ||||||.||||| .||.|. |.. ..||| ||..|   .....|||.||| .. .||||||.|. ||. . |. .. | .|.||..|
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPNKQGDSVKFGNFKVELESLEACT-GGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISID
||........||.|.|.||. .|.. . . | ..... ...|.|.|||.|.|||.|||. ..|||..|..|.  . .  .||..||||||||||..|.||
WpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

SVVAHAKKTRM---VDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
 |    |. ..   .|||. |...|..|. .||||||| ..| ||.|
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 990-1111 1.7e-84 278.5 In-house 271-392 (392) alignment 
Range on Protein: 990-1111
Range on HMM: 271-392/392.0
SQNDKASHTVTQYQFHGWPKHGSDQQSGARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
 .. ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.|||.|||||||||.|||||||.|||
frslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqt

GEEYAFIYDVIREYLHTEKYEQ
.|||||.|||||||||||||||
eeeyafvydvireylhtekyeq
0039614 (Phosphotyrosine protein) phosphatases II 596-868 2e-83 275.5 In-house 23-294 (297) alignment 
Range on Protein: 596-868
Range on HMM: 23-294/297.0
AFVNKNRHTALFFEEFHDLPGPDIyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMV
 ...|   . |...|| .|.   . ....|... | .|||||.|||||. |||| ..|.  ..||| ||||.. .|   ...||.|||.  ...||||||
lllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WQENVTTIAMVTKLQEGDKiKCRQYWPNKQGdsvKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG
|...||.| |.||| | .. || ||||...|   ..|.|.|.| . | . | . |........  ||||.|..| ||| ||| ....||.|...|.  . 
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

Q--YTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNT
.    .| ..||||||||||..| .. .. . .|.. |||.. |  .|..||..||| .|| |.| |.|| |....|
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0043336 (Phosphotyrosine protein) phosphatases II 602-861 2.2e-83 275.2 In-house 17-275 (278) alignment 
Range on Protein: 602-861
Range on HMM: 17-275/278.0
RHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTI
   .|. .||..|.  .......|... | .|||||.|||||. ||||....  ..||| ||||.. ..  ...||.|||.  ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLQEGDKIKCRQYWPnkqGDSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPL
 |.|.| | ...|| ||||   |.|...|.|.|.| . | . . . |....   . . .||||..|.. ||| ||| ..|.||.|.|.|.       .|.
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
..||||||||||..| .. .. ...|.. ||... |  .|..|| .||| .|| |.| |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 604-863 2.8e-83 274.3 In-house 14-276 (281) alignment 
Range on Protein: 604-863
Range on HMM: 14-276/281.0
TALFFEEFHDLPGPDIYPQTVAQ-KEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIA
.| | ||...|   ..   ..|  .. | .||||.||  || .|||..  ..  ..|| ||...|....||.|||.|||  ||...||.|||...|..|.
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MVTKLQEGDKIKCRQYWPNKQgDSVKFGNFKVELESLEACTGGVKRKMTM-RKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT-HPLI
|||.  |..|.|| .|||...  ..|.|...|. .. |. .  ..||... |.. . |.|.|...| |||.|||. |. ||.| |||.  . . | .||.
mvtreieagklkChrYWPddn.selkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

IHCSAGVGRTGVVISIDSVVAHA-KKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
|||||||||||. |..| .| .. ......|| . |...|..| .||||  ||.|.| |||. |
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045450 (Phosphotyrosine protein) phosphatases II 594-861 4.2e-82 271.6 In-house 19-302 (307) alignment 
Range on Protein: 594-861
Range on HMM: 19-302/307.0
FPAFVNKNRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYI--------PSFDNEKAYIASQGPNAA
.    . . . .  ||.. ..  ..... ..|... | .|||||.|||||. |||| ..|.  ..|||.||||.        ...|. ...|| |||   
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

SMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKqGDSVKFGNFKVELESLEACTGGVKRKMTMR---KGDDCRTVTQFHFTEWPDKGVPKHTSSL
...|||||.|...||.| |.|.| | ...|| ||||.. |... .|||.|.| | | . | . |....    . .  ||||.||.|.||| |||.....|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRM---VDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
|.||.||.. ...    .| ..||||||||||..| .. .  . .|. .   ||... |  .|..|| .||. ||| |.| |.||
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 622-899 6.2e-82 269.9 In-house 35-313 (314) alignment 
Range on Protein: 622-899
Range on HMM: 35-313/314.0
QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPN
  .|.|. | .|||...||.|| .||.| .||. |.||| ||..| |. . .|.|. |||    . ||||.|..|| ..| |.|.|.|  ..|| .|||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

kqgDSVKFGNFKVELESLEACTGGVKRKMTMRK----GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISID
   |. ..|..|||| . |. .  |.| ....|     .. |.| ||.|. ||| .||..  .|||....||. . .   ....||||| ||||. | ||
...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

SVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVDGNGRSKMSKEFQ
.|.  ... ..||||| | ..| ... ||.|.||| ||| ..||  |  .| ||| .|     .          |.. .|||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
subfamily_Ptp69D_pd Subfamily Ptp69D 596-882 1.6e-81 268.8 In-house 12-305 (307) alignment 
Range on Protein: 596-882
Range on HMM: 12-305/307.0
AFVNKNRHT-ALFFEEFHDLPGPDIYPQT-VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMV
|.....|.|  .. .|.. |.   |  .| |..|. |. ||||..| ..|. ||||..|    .||| |||.| .....| .||.|.|  | ..|||||.
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

WQENVTTIAMVTKLQEGDKIKCRQYWPNKqgDSVKFGNFKVELESLEACTGGVKRKMTMRKGD-------DCRTVTQFHFTEWPDKGVPKHTSSLLKFIK
.. .||.| |...|.| .. || .|||.   | |..|.  |.| | | ..  ..|.. . | .       | | |.|.|.|.|.|  ||... .|||.|.
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDL
.|.  . .   |...||||||||.|.....||.. . |.   ||.|..| ..|..|. .||  ||| |.| |.|.   . .| . | .. |... |
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
Y_phosphatase Protein-tyrosine phosphatase 630-861 1.8e-81 268.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 630-861
Range on HMM: 1-235/235.0
NLKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKF
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.|||   ...|||||||||.|..|.|.|.|.| .. || ||||.....|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNFKVELE-SLE-ACTGGVKRKMTMRKGDDC---RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAK
|..||||. . . .... . ||....| ..    |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ...
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

KTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
... |||...| ..|..|| |||. |||.|.| |.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 630-861 1.8e-81 268.4 In-house 1-235 (235) alignment 
Range on Protein: 630-861
Range on HMM: 1-235/235.0
NLKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKF
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.|||   ...|||||||||.|..|.|.|.|.| .. || ||||.....|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNFKVELE-SLE-ACTGGVKRKMTMRKGDDC---RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAK
|..||||. . . .... . ||....| ..    |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ...
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

KTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
... |||...| ..|..|| |||. |||.|.| |.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 623-863 2e-80 264.6 In-house 2-242 (250) alignment 
Range on Protein: 623-863
Range on HMM: 2-242/250.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIkCRQYWPNK
.||.|  |..|||| .|...||.|| ||  .   .||| |||.. ..|..||.||.|||  |.. ||||||..|...|| |.|.|.| .|  . |||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

QgdSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVISIDSV
.  . |.|. .|.| | |  .  .|||. .   |  | |.| |.||. |||||||... . |...|.|.| . |  . |.|..|||||||.|  | ||.|
k..aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
. ..|| ..||||...  .|..|| .|...||| |.| ..|. |
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 602-882 5e-78 257.5 In-house 20-307 (325) alignment 
Range on Protein: 602-882
Range on HMM: 20-307/325.0
RHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMV--WQenvT
.    |  ||  ||  |   ..|| |  | .|||.||....| .|| ||  .| |.|||.||||. .. . . ..|.| |..|...|.||.|  |.   .
qdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...c

TIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGD--DCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTH
.. .|.   ...| .| .|||.. |.|..|| ..|.| ..|  .  |.|.. ... .  . |.| ||..  |.| ||.|. ..|. ... ||| . . | 
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

------PLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDL
      |...||||||||||| ||. |..|.  .   ||.|.|| ..|..|| ||.| .|| .|| |. | ..  || .||  |  .|  |
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklssl
subfamily_PTPRG_pd Subfamily PTPRG 618-867 6.8e-77 254.0 In-house 35-291 (563) alignment 
Range on Protein: 618-867
Range on HMM: 35-291/563.0
DIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHS-DYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCR
.  . . .||. | .|||| ||..||..||||. . .. .. || ||.||  .  .||.||.||| .  .||||||.|..||..| |.|.|.|  . || 
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcd

QYWPNkqGDSVKFGNFKVELESLEACTGGVKRKMTMRK-----GDD---CRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVG
.|||.   .|...|...| |.. |  .   .|......     ...    ..|.|.|.|.|||.|||.|.   |.|.|  .| . . . |...|||||||
vYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvg

RTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRN
|||. | .|...   ..  .|.||.|.  || .|...|||.||| |.. |.|| .. ..
rtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
0040439 (Phosphotyrosine protein) phosphatases II 621-861 1.4e-76 252.7 In-house 2-244 (249) alignment 
Range on Protein: 621-861
Range on HMM: 2-244/249.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
. .||... |..||||..|||||. ||||..... ..||| |||||. ..  ...|| |||   ...|||||.|....|.| |.|.|.| ...|| ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NkqGDSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVISI
.  |.|...|.|.|.| | | . . . |....   . .. |||.....| ||| |||.....||.||..|.  . .    .|...||||||||||..| .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
. .. . .|.. ||... |  .|..||..||. ||| |.| |.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 616-887 4.6e-75 247.9 In-house 47-315 (319) alignment 
Range on Protein: 616-887
Range on HMM: 47-315/319.0
GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTklqegdKIKC
|..   || |  . |  |||. |||..| ..|||| .. .  ||| |||..  . ... |||.|||   ...|||||.|. |..|| ..|      | ||
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkc

RQYWPNKQgdSVKFGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHPLIIHCSAGVGRT
 ||||.|    .| ..|||...|.| .   | |.. . .     | | .|||||  |||.|||...| |....| |.  . .    .....|||||||||
sqywplki..vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVD
|| | .| ..   |. ..|||.||| ..|..|. .||   || ||| |.||. |. .. . .  |  .|..| .  |
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnksd
0042113 (Phosphotyrosine protein) phosphatases II 623-861 3.6e-74 244.5 In-house 2-241 (245) alignment 
Range on Protein: 623-861
Range on HMM: 2-241/245.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNk
.||... | .||||..|||||. |||| ...  ..||| ||||.. ..  . .||.||| . . .|||||.|....||| |.|.. | ...|| ||||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

qGDSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QYTHPLIIHCSAGVGRTGVVISIDSV
 |.|...|.|.|.| | | . . . |....   . |  |.|...|.. ||| ||| ....||.|...|.        .|...||||||||||..| .. .
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

VAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
. ...|.. |.... |  .|..|| .||| .|| |.| |.||
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 621-887 4.2e-74 244.6 In-house 16-279 (284) alignment 
Range on Protein: 621-887
Range on HMM: 16-279/284.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTklqegdKIKCRQYWP
 || |  . |  |||. .||..| ..|||| .. .  ||| |||.|  . ... |||.|||   ...|||||.|. |..|| ..|      | || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

NKQgdSVKFGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVIS
.|    .| ..|||...|.| .   | |.. . .     | |...||||  |||.|||...| |....| |.  . .    .....||||||||||| | 
lki..vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

IDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVD
.| ..   |. ..|||.||| ..|..|. .||   || ||| |.||. |. .. . .  |  .|..| .  |
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnksd
subfamily_PTPN6_pd Subfamily PTPN6 605-860 7.4e-74 243.5 In-house 26-294 (306) alignment 
Range on Protein: 605-860
Range on HMM: 26-294/306.0
ALFFEEFHDL---PGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIP--SFDNEKAYIASQGPNAASMDDFWRMVWQENVT
| | |||..|      . . .. ..|  | .|||||||||.| .||.|.  ...| ||| ||.||   . ...|.|||.||   . . |||||||||| .
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

TIAMVTKLQEGDKIKCRQYWPNKQGDSVkFGNFKVELESLEACTGGVKRKMTMR---KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT
 | |.||  |  | || .|||... ..  .|. .|.  | .. .  . |....    |....|.| |.||..|||.||||... .|.|...|.. . . .
vivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

----HPLIIHCSAGVGRTGVVISIDSVVAHAKKTR---MVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
     |...|||||.|||| .| || ..   .|.     .|. ..|  .|. |  .|||..|| |.| |. 
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0045098 (Phosphotyrosine protein) phosphatases II 607-865 1.3e-72 239.9 In-house 10-274 (278) alignment 
Range on Protein: 607-865
Range on HMM: 10-274/278.0
FFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKleviddiphsDYFNASYIPSFdnEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTK
. | .. |. ....  |.|... ||.|||||.|||||. |||          || |||||...   |..|| |||    ..|||||.|....|.| |.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LQEGDKIKCRQYWPNkqGDSVKFGNFKVELESLEACTGGVKRKMTMR------KGDDCRTVTQFHFTEWPDKGVPKHT--SSLLKFIKEVKADHGQ----
|.|....|| ||||.  |.|. .|.|.|.|.| | .   ..|.....      ... .|.||..|.. ||| ||| ..  .|.|........ . .    
lvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------YTHPLIIHCSAGVGRTGVVISIDSVVAHAkkTRMVDVFNFVTNIRRKRPY-MVQTKEQYAFIYGAVLEDLLW
           .| ..||||||||||... .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN9_pd Subfamily PTPN9 609-861 2.6e-71 235.1 In-house 20-288 (297) alignment 
Range on Protein: 609-861
Range on HMM: 20-288/297.0
EEFHDLPGPDIYP-QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKL
.|. ..    .    .....  ||.||||...| ||..||.|. .|. ..||| ||...  . ..||.|| |||    ..|||||||...| .| |.|..
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrv

QEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT---------
 |  ..||.||||.....| .||...|.  . |     ..|.....  | .. |.|| | |. ||| |||. ..|||.....|.   .. .         
vergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkg

----HPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
     |...|||||.||||  |..|  ... ... .|||.. |  .| .| ...|| |||.| | ||||
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 625-861 3.9e-71 234.0 In-house 2-238 (239) alignment 
Range on Protein: 625-861
Range on HMM: 2-238/239.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKq
|.| .|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | ||.||||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

gdSVKFGNFKVELESLEACTGGVKRKMTMRKG--DDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVA
  . |. |..| |   |  .  . | . | .    . | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.||| . ||.||.|  ||  ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 625-861 4.7e-71 233.7 In-house 3-239 (239) alignment 
Range on Protein: 625-861
Range on HMM: 3-239/239.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKq
|.| .|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | ||.||||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

gdSVKFGNFKVELESLEACTGGVKRKMTMRKG--DDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVA
  . |. |..| |   |  .  . | . | .    . | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.||| . ||.||.|  ||  ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN13_pd Subfamily PTPN13 623-863 1.3e-69 229.5 In-house 30-269 (273) alignment 
Range on Protein: 623-863
Range on HMM: 30-269/273.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsdYFNASYI--PSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
.|..|. | .||||.|.|||| .||||.         | |||.|  |  ..|  |||.|||   ...|||.|||. ... |||||. .|..|.||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

NKQGDSVKFGN-FKVELESLEACTGGVKRKMTMRK--GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqYTHPLIIHCSAGVGRTGVVISID
.......|  | ..|||. ..   | | |......    . | |....|..||| |||... .||.|..||.  .   . |...|||||.||.|..|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

SVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
 |.   .. . .|| . | ..|..|  .||||.|| |.| |.|| |
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN3_pd Subfamily PTPN3 623-861 1.5e-69 229.1 In-house 34-273 (280) alignment 
Range on Protein: 623-861
Range on HMM: 34-273/280.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDdipHsDYFNASY----IPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQY
..|.|  ||.||||..|||||..||||.  .     || ||.|    ||| .  . |||.||| | .. |||.|||......| |.| | |  ..|| ||
saarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPNkQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGD--DCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISI
||. ..|....|.|.|..|. .. .  | |...... .  . |...|. ...|||.|||......|.|...|.. .   ..|...|||||.|||||.| .
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.  .|   ... | . . | ..| .|  .|||..|| |.  |.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 608-860 7.2e-69 226.9 In-house 8-265 (274) alignment 
Range on Protein: 608-860
Range on HMM: 8-265/274.0
FEEFHDLPGPDiyPQTVAQKEINLKKNRYKNILPYDSARVKLEVID-DIPHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVT
 .|| .||     .|   .   . .|||||.||| . .|| ||  . . . |.| || ||  .|. .|||.| ||| .  ..|||||..||.|. | |.|
ekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

KLQEGDKIKCRQYWPNKQGD--SVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTH---PLI
||.| .. || .|.|....   | ..|..... |.   . .   ||.....  ..|.|. . .|.|||. .|.....||....||. .. . ..   | .
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvv

IHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
.|||||.||||. |.|.  | . ... .|||.. |.|.| .|  ||||.||| .|. |. 
vhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 624-861 1.2e-68 226.0 In-house 14-262 (270) alignment 
Range on Protein: 624-861
Range on HMM: 14-262/270.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNK
. .   . | |||..|||   .||.|| ... ... |.|| |.. ||. .|.|||..|| .... .||||.|.|.||.|.|.|.|.|  . || .|||..
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

QGD--SVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTS------SLLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGV
...  ....|. ||  .| |  .| .........  . | .. |....|||.|||...       .||| ...|.. . .    .||..||||||||||.
pkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

VISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
.| .| .|   ..|. ||| . ....|..|. .||. |||.|.| ||.|
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0037934 (Phosphotyrosine protein) phosphatases II 622-861 4.5e-68 224.7 In-house 2-240 (243) alignment 
Range on Protein: 622-861
Range on HMM: 2-240/243.0
QTVAQKEINLKKNRYKNILPYDSARVKLeviddiPHSDYFNASYIPSFDNekaYIASQGPNAASMDD----FWRMVWQENVTTIAMVTKLQEGDKIKCRQ
...|... ||.||||..|||||  ||||      . |||.||..|. ...   .||.|||   . .|    ||||.|....|.| |.|.|.| ...|| |
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPnkqgDSVKFGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD----------HGQytHPLIIHCS
|||    ..| .|.|.|.| | | . . . |.....    .| .|.|...|.. ||| ||| ....||.|..||..           ...  .|...|||
ywp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCs

AGVGRTGVVISIDSVVAHAkktRmVDVFNFVTNIRRKRPY-MVQTKEQYAFIYGAVLE
|||||||..| .. .  .    . ||... |  .|..||. .||| .|| |.| |.||
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 630-861 2.3e-67 221.7 In-house 3-237 (237) alignment 
Range on Protein: 630-861
Range on HMM: 3-237/237.0
NLKKNRYKNILPYDSARVKLEVIDDIphSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQgDSVK
|  |||| ||  || .|| |.       ||| ||.|. .||   | |||.|||  .| ||||.|||||. . | |.| | ||...|| .|||. . .   
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

FGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV--KADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHA
.| . | |   |. .    | ... |     . | . |..|| |||.|||..|..||.| |..  .. | . . | ||||||||||||... ||... .|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
|. ..||..|.| .|   |||..|||.|| ||. ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0050432 (Phosphotyrosine protein) phosphatases II 860-1106 1.2e-66 220.5 In-house 9-301 (308) alignment 
Range on Protein: 860-1106
Range on HMM: 9-301/308.0
LEDLLWRNTLIPVIHFTDHLQDLHT-SVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILdSPEHDYINASYIKGV----H
|| ||.|.| |.|.... ...||.    . ........||. |.  .|  .....| |.|..|||| . .|....||.| ....|||||||..|      
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklp

CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQN-----------------------------------------------DKASHTVTQYQFHGW
..|  || |||.|| ||| || ... ..||||..  .|                                               |. |.|||......|
rkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnW

PKHGSDQQsgARSLLKLIRAVKGSTnskKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLHT
| ||  ..  ...||.....|. |    ..  |.|||  | ||||.|...  .. |. ... ||.|..||.||  |...||| | | |.|... |||..
pdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 623-864 6.2e-66 217.3 In-house 40-279 (287) alignment 
Range on Protein: 623-864
Range on HMM: 40-279/287.0
TVAQKEINLKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNK
|..  . | .|||...||..|  || |.      | || ||..| .. ..||.|....| .  . .||......|||.| |.....| |. .| ||||..
thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee

QGdsVKFGNFKVELESLEACTGGVKRKMTMRK---GDDCRTVTQFHFTEWPDKG-VPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDS
.   | .|....|| . |  .| ..||. ...    .| ..|.|...|.|...| |... ..|| . . .|... .   ....|||..|||... .... 
ks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat

VVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLL
 . ..|.   .|||. . . | ..| .||| ||| ||. .||| | 
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 592-862 6.8e-66 217.1 In-house 5-282 (290) alignment 
Range on Protein: 592-862
Range on HMM: 5-282/290.0
AQFPAFVNKNR--HTALFFEEFHDLP-GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPH--SDYFNASYIPSFDNEKAYIASQGPNAASM
 .|  || ...   .  | ..|. |  |   .  ||.  . | ..||..||..||  |. |  | . .    .| ||.||  . ..|.||| |||    .
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

DDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKqgDSVKFGNFKVELESLEACTGGVKRKMTMRKGDD---CRTVTQFHFTEWPDKG-VPKHTSSLL
 |||...|||.|| | |.|. .| .| ||.||||..  |. ..|.|...| . |.... ..||. ... .    ...|||...| |...| |......||
vdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

KFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLED
 . . .|  . .  .....|||..|||..| ....  . ..|..  .|||. . . | ..| .|||..|| .|.  ||. 
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_PTPN23_pd Subfamily PTPN23 623-862 1.6e-65 215.8 In-house 36-279 (288) alignment 
Range on Protein: 623-862
Range on HMM: 36-279/288.0
TVAQKEINLKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDNE-KAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPN
..|  ... .|||...|||||..||||.      . || |||.. .       .||.|.| . .. |||.||... . .| |... .| .| |. .|||.
siaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

KQGDSVKFGNFKVELESLEACTGGVKRKM--TMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA----DHGQYTHPLIIHCSAGVGRTGVVIS
..|..||||...| |.| .     |.|..  .... |  ..|.  ..|.||. |||.  ..||.|..||..     . .   ||..|||||||||||.  
dkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal

IDSVVAHAK-KTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLED
. ..|.  . .  ..|. . |  .|..| .|||.|||. | | |||| 
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0051299 (Phosphotyrosine protein) phosphatases II 867-1104 1e-63 210.9 In-house 2-286 (288) alignment 
Range on Protein: 867-1104
Range on HMM: 2-286/288.0
NTLIPVIHFTDHLQDLHtsvdGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKG--VHCTFMTT
.| |.| ....... |.     || ... .||. |..  |  .....| | |..|||| . .|....||.| .    ...||||||||.|    ..|. |
dteisveellklvlkll....angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQ------------------------------------------------NDKASHTVTQYQFHGWPKHGS
| |||.||.||| || ... ..||||..                                                    |. |.|||......|| || 
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

DQqsGARSLLKLIRAVKGSTNsKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
 .   ...||...|.|. . . ...  ..|||  | ||||.|...  .. |. ... ||....||.||  |...||| | | |.|... |||
pd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 601-872 5.9e-63 207.4 In-house 5-275 (283) alignment 
Range on Protein: 601-872
Range on HMM: 5-275/283.0
NRHTALFFEEFHDLPGPDIyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIP---SFDNEKAYIASQGPNAASMDDFWRMVWQEN
.    ||.| .. |  ||  . ..|  . | .|||...|.|.|  ||.|.        || ||..||   | ...| ||..|.|    . |||.||..|.
vnnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

VTTIAMVTKLQEGDKIKCRQYWPNKqGdSVKFGNFKVELESLEACTGGVKRKMTMRKG---DDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ
.|.| |.|||||. .||| ||||.. | |...|.| | |.   .    .......|.     .   .. . . .| . |      ||.|| | .     .
itaivmltklqedlrikCsqyWPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

YTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPV
   |...|||.|.|||.| |.. . | .|.   .||||. |...| .|. .|||..|| ... .|||. |  .| |  
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
0036941 (Phosphotyrosine protein) phosphatases II 887-1110 1.9e-61 203.3 In-house 8-283 (297) alignment 
Range on Protein: 887-1110
Range on HMM: 8-283/297.0
DGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIV
. .......|||..|.|  .   .. .| |.| .|||| . .|....||.||....|||||||..| .   .|. || |||.|| ||| ||.... ..||
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKSQN------------------------------------------------DKASHTVTQYQFHGWPKHGSDQqsGARSLLKLIRAVKGSTNSK-
||..  ..                                                .. |.|||.....||| ||  .   ..|||..|..|.   .   
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllp

KEFSILVHCLSGAGRTGVFCTATECIAQVA---EGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLHTEKYE
..  .||||  | ||.|.|..|  .. |.    . . |||...||.||  |...||| | | |.|... |.| . .. 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0046845 (Phosphotyrosine protein) phosphatases II 894-1106 3.3e-61 202.5 In-house 2-276 (284) alignment 
Range on Protein: 894-1106
Range on HMM: 2-276/284.0
MSKEFQSLCPDPPAS--QTRSGLAPDNHPKNRYGNNIPLERNRVILDS-----PEHDYINASYIKGV-------HCTFMTTQMPLPTTVSDFWSMVLKYK
. .||. |.   .    ... .|.| |. |||| . .|....||.|.|     ...|||||||..|        ...|. ||.|||.|| ||| ||....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PSTIVMLNDKSQN----------------------------------------------DKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTN
 ..||||..  .|                                              .. |.|||......|| ||  ..  ...||...|.|. . .
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrelle

S-KKEFSILVHCLSGAGRTGVFCTATECIAQVAEGN---SVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLHT
. ...  |.|||  | ||||.|...  .. |. ...    ||....||.||  |...||| | | |.|... ||| .
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 887-1104 6.3e-61 201.6 In-house 7-272 (273) alignment 
Range on Protein: 887-1104
Range on HMM: 7-272/273.0
DGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKG--VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIV
. .|.... .||. |.. .|   .. .| |.|. |||| . .|....||.|.....|||||||..|  .  .|. ||.||| || ||| || ... ..||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLNDKSQN-----------------------------------------------DKASHTVTQYQFHGWPKHGSD-QQSGARSLLKLIRAVKGSTNSKk
||..  ..                                               .. |.|||.....||| ||   . .   ....|.| .  ...|. 
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.

eFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
   ..|||  | ||||.|...  .. |. ... ||....||.||  |. .||| | | |.|... |||
.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN14_pd Subfamily PTPN14 606-861 1.5e-59 196.5 In-house 24-294 (300) alignment 
Range on Protein: 606-861
Range on HMM: 24-294/300.0
LFFEEFHDLPGPDIYPQ-TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIpHSDYFNASYIPS--FDNEKAYIASQGPNAASMDDFWRMVWQENVTTIA
  | |.  .|      . ..|. . | .|||.|..|||. .||.|    .  ...| ||| |      .|. ||..|||    . |||.|||...|. |.
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MVTKLQEGDKIKCRQYWPNK--QGDSVKFGNFKVELESLEACTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA--DHGQY-
|.|. .|. | |. .|.|..  . ..|.||.|||  .  |  .  . ......     . |||  . .|.|||.|||.  .. |....||..   . .  
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

------THPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
        |...|||||||||||.|  | ..|  .. . .|. . .. .|..| ..|||  || |.| ....
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_CG7180_pd Subfamily CG7180 601-864 7.4e-59 193.8 In-house 13-291 (296) alignment 
Range on Protein: 601-864
Range on HMM: 13-291/296.0
NRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTT
... ...  |..  |  .|     . .. |..|||. ...||| .|| || .|   .||| ||.|. ||  .|.||  ..|   ..|.|||.|..|.. .
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

IAMVTKLQEGDKiKCRQYWPNKQgdSVKFGNFKVELESLEACTGGVKRKMTMRKG------------DDCRTVTQFHFTEWPD-KGVPKHTSSLLKFIKE
. ..||  .  | .. .|||||.    ..|.. ||. . .  .  ..|.. . |              . |.|..|..|||.  . ||  |..|..... 
vvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VKADHGQY-----THPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLL
|.   ..      . |.....| |..|.|| ..||  .  ..|.  ||||..|  .||.|| .|...|.| .||  .|| .|
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPRN_pd Subfamily PTPRN 622-862 1.3e-58 193.1 In-house 48-291 (297) alignment 
Range on Protein: 622-862
Range on HMM: 48-291/297.0
QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
..||..| |.||||.|..|||| .||||.   .  .||| ||| |   |  . ||||.||| |... |||.|||.. |. | ..|.|.| .  .|..|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

NKqGDSVkFGNFKVELESLEA-CTGGVKRKMTMR--KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISID
.. | .| .. ..|.| |    |   . | . ..  . .. ||||||||  ||..|||  . |||.| . |   .   . |...|||.|.||||| | ||
de.Gsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SVVAHA-KKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLED
 |...  |  . .|.   .  .| .|| .|.||.|. |...|| |.
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 605-875 4.7e-58 191.7 In-house 20-291 (439) alignment 
Range on Protein: 605-875
Range on HMM: 20-291/439.0
ALFFEEFHDLP--GPD-IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTI
 .| |.|. .    ||     ..| .| .  |||||.. ..| .|| |. |  .||| |.|| ||  . ..| |||.|||.  . |||||.|......||
eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

AMVTKLQEGDKikcrqYWPNKqgDSVKFGNFKVEL----ESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-ADHGQYT
 |.|.| |  |     ||| .  . | .|.  |      |  . .  |.|      ...  ||| |||.. |||| || ..| .|.|.. .. |.  . .
vmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

HPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIPVIHF
 |...|||||||||| .|..|  . . |    ||.   |. .|..|  |||.  || ||| |||||. . .. . . .|
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 601-862 5.8e-58 191.0 In-house 11-292 (301) alignment 
Range on Protein: 601-862
Range on HMM: 11-292/301.0
NRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVID--DIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENV
. |.  | |....|   .  . ||  .| | . ||.||| .||  |. |.     |. . .| ||||| .. ..|..||.|||    . ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLE-----------------ACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSL
..| |||.|.|| | ||.||||| . .| .||.|.|.| .                   .  | ..||. ...  . ..|.|.. |.||. || .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFIKEV-KADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLED
|. | .| .. .     |...|||..|.|.|| .|..  .  .|    ||||. .  .||..| .|.| ||| .|| .. . 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_PTPN1_pd Subfamily PTPN1 619-862 5.8e-58 190.9 In-house 21-270 (290) alignment 
Range on Protein: 619-862
Range on HMM: 21-270/290.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQY
 .|...|... | ..|||... ||| .|.|||  |     || ||| .   . .. || .||| .  .| ||.|||...  .. |. |. | ..||| ||
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPNKQG-DSVKFG--NFKVELESLEACTGGVKRKMTMRK--GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH--GQYTHPLIIHCSAGVGRTG
||...  .....   ..||.| | |     . |.. . .   ...|....||.| ||| |||.  ...|||. .|.      .   | .||||||.||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VVISIDSVVAHAKKTRM---VDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLED
 .. .|..... .|.     ||. . . ..|. |  ..||..|  | | |.|| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
0040438 (Phosphotyrosine protein) phosphatases II 883-1104 1.1e-56 187.8 In-house 13-276 (317) alignment 
Range on Protein: 883-1104
Range on HMM: 13-276/317.0
HTSVDgngrSKMSKEFQSLCPDPPAsQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVL
. |       ....||. |.  ..   .. .. |.|..|||| . .|....||.| ...    .|||||||..|     .|  || ||| || ||| || 
lksdf....talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvw

KYKPSTIVMLNDKSQN--------------------------------------------DKASHTVTQYQFHGWPKHGSDQqsGARSLLKLIRAVKGST
... ..||||..  ..                                            |. |.|||.....||| ||  .    ..||....||. . 
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllldfleavreal

NsKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
. ...  .||||  | ||||.|..|  .. |. ... ||....||.||. |...||| | | |.||...|||
e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 879-1104 1.2e-56 187.7 In-house 19-289 (297) alignment 
Range on Protein: 879-1104
Range on HMM: 19-289/297.0
LQDLHTSVDGNGRSKMSKEFQSLCPDPPaSqTRSGLAPDNHPKNRYGNNIPLERNRVILDS-----PEHDYINASYIKGVHC---TFMTTQMPLPTTVSD
|  |.   . |..... .||..|.  .| . .. .| | | .|||| . .|....||.| .     ...|||||||..| ..   .|  || ||| || |
ldlllllekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWSMVLKYKPSTIVMLNDKSQN----------------------------------------DKASHTVTQYQFHGWPKHGSDQ-QSGARSLLKLIRAVK
|| || ... ..||||..   .                                        .. |.|||..|..||| ||  .  .   ..|.|.| . 
FwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreal

GSTnsKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
 ..  .|.  .||||  | ||||.|..|  .. |. ..  ||....||.||  |...||| . | |.||...|.|
ael..pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0043336 (Phosphotyrosine protein) phosphatases II 879-1104 3.4e-55 182.8 In-house 7-277 (278) alignment 
Range on Protein: 879-1104
Range on HMM: 7-277/278.0
LQDLHTSVDGNGRSKMSKEFQSLCPDPPaSQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKGV--HCTFMTTQMPLPTTVSDFW
|...   .  |.......||..|.  ..   .. .| |.|..|||| . .|....||.|.. .    .|||||||..|     .|  || ||| || |||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

SMVLKYKPSTIVMLNDKSQ-------------------------------------------NDKASHTVTQYQFHGWPKHGSDQqsGARSLLKLIRAVK
 || ... .|||||..                                               |. |.|||.|...||| ||        .||....||.
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavr

GSTNsKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
   . ...  .||||  | ||||.|...  .. |.  .  ||....||.||  |...||| . | |.|....|||
eale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 888-1104 5.8e-55 182.5 In-house 23-304 (307) alignment 
Range on Protein: 888-1104
Range on HMM: 23-304/307.0
GNGRSKMSKEFQSLCPDPP--ASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS-----PEHDYINASYIKG----------VHCTFMTTQMPLPTTVSD
 ...... |||..|..  .     ....| | |..|||| . .|....||.| |     ...|||||||..           .  .|. || ||| || |
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWSMVLKYKPSTIVMLNDKSQ----------------------------------------------NDKASHTVTQYQFHGWPKHGSDQQsgARSLLKL
|| |. ... ..||||..                                                  .. |.|||.....||| ||  .     .||..
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldf

IRAVKGSTNSK-KEFSILVHCLSGAGRTGVFCTATECIAQVAEGNS---VDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
|..|.   ..  |.  .||||  | ||||.|..|  .. |. ...    ||....||.||. |...||. | | |.|....|.|
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 893-1105 1.6e-54 180.5 In-house 8-273 (278) alignment 
Range on Protein: 893-1105
Range on HMM: 8-273/278.0
KMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVIldspehDYINASYIKGVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQ-
... ||. | . .. |.   .| ..| .|||| . .|....||.      ||||||||.| . .|  || |||.||.||| |. ... ..||||..  . 
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-----------------------------------------------NDKASHTVTQYQFHGWPKHGSDQQSGARSLLKLIRAVKGSTN-----------
                                               .|  |..||......|| ||.  ..  .|.|.|.. ..   .           
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

-SKKEFSILVHCLSGAGRTGVFCTATECIAQVaeGNSVDIFQTVKMLRADRMQ-SVQTGEEYAFIYDVIREYLH
   ..  .||||  | ||||... |  .. ..  .. ||....||.||  |.. .||. | | |.|....|.|.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 995-1106 2.7e-54 179.1 In-house 171-279 (315) alignment 
Range on Protein: 995-1106
Range on HMM: 171-279/315.0
ASHTVTQYQFHGWPKHGSDQQSGarSLLKLIRAVKGStNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYA
.|.||||.||..||..|.|.|..  ||||||..||.. | |||||.||||..|.|||||.... |..||.....|||.|..||.|||.|.. ||| ||||
esrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

FIYDVIREYLHT
||||...|.|. 
fiydavledllw
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 625-860 2e-51 169.5 In-house 33-274 (287) alignment 
Range on Protein: 625-860
Range on HMM: 33-274/287.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDiPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKqG
|..  . ||||| ..||.| .|| |    .   ||| || |..|. ...|.||.||| ||.. ||||.|...........|.  |  . || .|||..  
aeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.e

DSVKFGNFKVELESLEACTG---GVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV-----KADHGQYTHPLIIHCSAGVGRTGVVISI
  .. | . | | . .           ..   .. ..| | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|.....
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
  .|   ...  ||| . |  .| .|  .||.  |. ..| |. 
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 996-1105 7.2e-50 164.5 In-house 171-277 (515) alignment 
Range on Protein: 996-1105
Range on HMM: 171-277/515.0
SHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKeFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAF
|.||||..|..||..|....  ..||||||..|| ...  . .....||..|.|||||.... ...|.......||.|..|. .|..|.. ||| |.|||
srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

IYDVIREYLH
||....|.|.
iygavledll
0042113 (Phosphotyrosine protein) phosphatases II 913-1104 4e-48 159.3 In-house 4-243 (245) alignment 
Range on Protein: 913-1104
Range on HMM: 4-243/245.0
GLAPDNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQ---------------
.| | |..|||| . .|....||.| ...    .|||||||..|     .|  || ||| || ||| |. ... .|||||..                  
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

-----------------------------NDKASHTVTQYQFHGWPKHGSDqqSGARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIA
                              |. |..|..|....|| ||    .  ..||.....|.   .....  .||||  | ||||.|..|  .. 
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvp..dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
|. .   |.....||.||  |...||| . | |.|....|.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 912-1104 4.2e-48 159.5 In-house 5-246 (249) alignment 
Range on Protein: 912-1104
Range on HMM: 5-246/249.0
SGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQ--------------
 .| | |..|||| . .|....||.| .    . .||||||||.|     .|  || ||| ||.||| |. ... ..||||..  .              
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

------------------------------NDKASHTVTQYQFHGWPKHGSDqqSGARSLLKLIRAVKGSTNSK-KEFSILVHCLSGAGRTGVFCTATEC
                               |. |.||...|...|| ||    .   .||..|.||.   ..  |.  .||||  | ||||.|..|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvp..psfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
. |. . . ||....||.||  |...||. | | |.|....|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0051429 (Phosphotyrosine protein) phosphatases II 655-862 3.5e-47 156.6 In-house 1-224 (272) alignment 
Range on Protein: 655-862
Range on HMM: 1-224/272.0
IPHSDYFNASYIPSFDN---EKAYIASQGPNAASMDDFWRMvWQENVTTIAMVTKLQEGDKIKCRQYWP----------NKQGDSVKFGNFKVELESLEA
.| |.|.||.... . .   ......|.||  .. .||||. ......|| ..... | .. || .|||          .    .. .|.. | | | | 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

CTGGVKRKMTMR---KGDDCRTVTQFHFTEWPDKGVPKHTssLLKFIKEVKAdhgqyTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVD--------
..  . |.....   . .. |.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ...   .. .||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFNFVTNIRRKRPYMVQTKEQYAFIYGAVLED
....|  .|..||..||| |||.|.| |.|| 
leeaveelraqrpgavqteeqylflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 630-871 4.5e-46 152.1 In-house 1-179 (182) alignment 
Range on Protein: 630-871
Range on HMM: 1-179/182.0
NLKKNRYKNILPYDSARvkleviddipHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTklqegdkikCRQYWPNKQgdsvkf
||.||||..|||||  |          ..|| ||... .    . .|| |||   .. ||.||......||| ..|         ...|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gnfkvelesleactggvkrkmtmrkgddCRTVTQFHFTEWPDKGVPKhTSSLLKFIKEVKAdhgqYTHPLIIHCSAGVGRTGVVISIDSVVAHakktrMV
                             |...|.... ||| |||  ...||.||.||..      .| ..||||||||||... .. .  .      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLIP
.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
0037934 (Phosphotyrosine protein) phosphatases II 912-1104 5.3e-46 152.5 In-house 4-242 (243) alignment 
Range on Protein: 912-1104
Range on HMM: 4-242/243.0
SGLAPDNHPKNRYGNNIPLERNRVILDSpeHDYINASYIKGVHcTFMTTQMPLPTTVSD----FWSMVLKYKPSTIVMLNDKS-----------------
 .| | |..|||| . .|....||.|..  .|||||..|...  ..  ||.||| || |    || |. ... ..||||..                   
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevty

-------------------------QN-DKASHTVTQYQFHGWPKHGSDQ-QSGARSLLKLIRAVKGST----NSKKEFSILVHCLSGAGRTGVFCTATE
                          . |. ...|..|....|| ||  .  .   ..|. .|..  ..    . ...  .||||  | ||||....|  
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

CIAQVaegnSVDIFQTVKMLRADRMQ-SVQTGEEYAFIYDVIREYL
.. ..    .||....||.||. |.. .||| . | |.|....|.|
mllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 607-860 2.4e-45 149.4 In-house 13-266 (281) alignment 
Range on Protein: 607-860
Range on HMM: 13-266/281.0
FFEEFHDLPG-PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEV-IDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMV
| .|| .||| |     || .. .| ||||| ||   | .||.|.| . .   .||  | || |   .. || .|||.  .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqyTHPLIIHCS
 .. | .. || .|.| .    ..| .. |. |        |  .. .    . | .|.. . ||||  ||. .  .|| .....|     . | .||||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRTGVVISIDSVVAHA-KKTRMVDVFNFVTNIRR-KRPYMVQTKEQYAFIYGAVL
|||||.| .....  .     .  . |. . |. .|   |   ||| .|| .|.  .|
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 623-864 9.3e-45 147.9 In-house 34-278 (307) alignment 
Range on Protein: 623-864
Range on HMM: 34-278/307.0
TVAQKEINLKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNK
||   . | .||||...   | .|. ...  |   |||  | |.    . | .|..|||  ... .|| |. ||.| .. |. |. |  ||||.|||| .
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

QGDSVKFGNFK--VELESLEACTGGVK------RKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqyTHPLIIHCSAGVGRTGVVI
.|.   ||.    . .. | | .           .. .  ....||.... ...|||.|||.   . . ... |. |    | |...||||||||.| ..
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtiv

SIDSVVAHAK-KTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLL
.|  |           |. ..| ..| .|.| .||. || ...  .|| .|
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0036282 (Phosphotyrosine protein) phosphatases II 658-856 3e-44 146.1 In-house 2-163 (174) alignment 
Range on Protein: 658-856
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNEKAYIASQGPNAasmddFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNkqgdsvkfgnfkvelesleactggvkrkmtmRKGDD
|||.|||..  .   . .||.||| |     ||.|......||. |.....| .. || .|||                                .. | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

CRTVTQFHFTEWPDKGVPKHTSsLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVISIDSVVAHAKkTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
 |.. |.... ||| |||  .  ||.|.|.|.  . .   .|...||||||||||... .. .  . . ...||....|  .|..||.|||| .|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 903-995 1.9e-42 140.2 In-house 29-127 (315) alignment 
Range on Protein: 903-995
Range on HMM: 29-127/315.0
PDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKA
|||.....|..  ..|..||||.|..||...||.|    |||..|||||||||.|..  .....|.||...|.|||.|||..|..||||...|...|| 
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdki
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 622-860 2.2e-41 136.4 In-house 48-280 (290) alignment 
Range on Protein: 622-860
Range on HMM: 48-280/290.0
QTVAQKEINLKKNRYKNILPYDSARVkleVIDDIPHSDYFNASYIPSFdnEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPN
. . .|. ..||||||..   | .||   ...|  . ||  | |.     .  .| .||. .... |.|||| ||.|..| |. .| |  | || ||.|.
rkifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

KQGDSVKFGNFKVELESLE-ACTGGVKRKMTMRKGDDCRT--VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqythPLIIHCSAGVGRTGVVISIDS
|.|. . ||.. |     .   .  .|. ...|. |. .   .  ..   |||| |.. | .||. .. ..   |    |...|||||.||||  ..|. 
keGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaiev

VVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
 .    . . .|. . |  .|. |   ||   ||  .  ..|
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 630-861 3e-39 129.6 In-house 48-285 (305) alignment 
Range on Protein: 630-861
Range on HMM: 48-285/305.0
NLKKNRYKNILPYDSARVKLEviDDIPHsDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKF
. .|||||..   |  |||||     || .|  | |. .  | | .| .| |   .  ||| | .|..| .| |. .|.|    || .|.. |..| ..|
eagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

GN----FKVELESLEACT------GGVKRKMTM--RKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqythPLIIHCSAGVGRTGVVISID
 .      | .|| ..          |.. . .    | . | ||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |. ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmle

SVVAHAKKTRMVDVF-NFVTNIRRKRPYMVQTKEQYAFIYGAVLE
 ..      ....     .  || .|   .|| .|| |..  .|.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 991-1110 5.2e-39 129.1 In-house 170-290 (297) alignment 
Range on Protein: 991-1110
Range on HMM: 170-290/297.0
QND-KASHTVTQYQFHGWPKHGSDQQSGARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
... || . | ||||  ||..  ...  |.||||||  |. . ....|  .|||||.| |||||..|  ...|.. . ..||||..||.|| .|.. |||
kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt

GEEYAFIYDVIREYLHTEKYE
 |.|.|.| .. |.| .|...
keqykfvyvavleallsedtr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 624-787 8e-39 128.2 In-house 27-192 (297) alignment 
Range on Protein: 624-787
Range on HMM: 27-192/297.0
VAQKEINLKKNRYKNILPYDSARVKLEviDDIPHSDYFNASYIpSFDNE---KAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
.|...  |.||||..|| .|..||||     |. .|| || |.  | .|     || .|||  |..||||..|....| .|.||.||||. . ||  |||
sakrnsslrknryrdilatddtrvkll..rviterdyinadyv.vfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

NKQGDSVKFGNFKVELESLEAC---TGGVkRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKE
. ...  | |.. ||  |  .    .  .  ....   .. | |.   |  |||.|||     | .|  .
svvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 626-864 2.6e-38 126.4 In-house 51-290 (305) alignment 
Range on Protein: 626-864
Range on HMM: 51-290/305.0
QKEINLKKNRYKNILPYDSARVKLeviDDIPHSDYFNASYIPS-FDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQG
  .|.  ||||...   | . |||   |. . |||  | |.   .  || .|..|||   ..|.|| || |..|  | |. |  |  |.|| ||||  ||
sadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

DSVK--FGNFKVELESLEACTGGVKRKMTMR----KGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqytHPLIIHCSAGVGRTGVVISIDS
. ..   |    ..          . ..|.      ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. 
eklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaiey

VVAH-AKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLL
.. . |.. .   . ..|  .| .| . .|.  || ||.  .|. .|
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
0043147 (Phosphotyrosine protein) phosphatases II 656-856 4.9e-38 125.9 In-house 3-154 (172) alignment 
Range on Protein: 656-856
Range on HMM: 3-154/172.0
PHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLqegdkikcrqywpnkqgdsvkfgnfkvelesleactggvkrkmTMRKG
..||| ||||..     . .|| |||    ..|||||......|.| ..|.|                                           .  . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

DDCRTVTQFHFTEWPDKGVPkHTSSLLKFIKEVKA-DHGQYTHPLIIHCSAGVGRTGVVISIDSVVahakktRMVDVFNFVTNIRRKRPYMVQTKEQYAF
. .|.. |.... ||| ||| ... ||.|.. ..   . .  .| ..||||||||||... .. .       . ..... |  .|.|||..||...|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IY
.|
ly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 629-858 6.3e-38 125.3 In-house 32-254 (267) alignment 
Range on Protein: 629-858
Range on HMM: 32-254/267.0
INLKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDkIkcRQYWPNKQGDSVK
 | ..||. . |||| .|| |   .     .| ||||. ..  ..|.|. |.|   .. ||. .. ...|..| ..||  ... |  |..|| | |.. |
knqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.i..rlfwPPkmgqakk

FGNFKVElESLEACTGG---VKRKMTMrKGDDCRTVTQFHFTEWPDKGVPKHTSS-LLKFIkeVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAK
. .. ||  |||        .  .. . | . .. || ... .|  .   |     |.  .   | .  .  .||...||.||||.|  . ||| .  ||
yqdltve.hslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerak

KTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGA
.  ..|.|.|. .|| .|. .|.|||.| .|.  
tegvsdifdflrkirsqriglvdtkeryiyihel
0049772 (Phosphotyrosine protein) phosphatases II 623-865 6.8e-38 126.5 In-house 39-282 (314) alignment 
Range on Protein: 623-865
Range on HMM: 39-282/314.0
TVAQKEINLKKNRYKNILPYDsARVKLEvIDDIPHSDYFNASYIPSFdneKAYIASQGPNAASMDDF----------WRMV--WQENVTTIAM-------
.||... | .||||..|||.|  ||.|    ..  |||.||||. .|   ...||.|||.   ..||          ||||  .. || .| |       
lvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTKLQEGDKIKCRQYWPNKQgdsvkfgnfkvelesleactggvkrkM-------TmrkgddCRTVTQFHFTEWPDKGVP--KHTSS
               ..| ..  . . ..... .                                          |.. ... . .|| ..|  ..  .
delsrLdaAlgKtpllildgngneptaadlellk..........................eelydpelf......erlgikylripvpDgsaplledfde

LLKFIKEVkadhgQYTHPLIIHCSAGVGRTG--VVISIdsVVAHAkktRMvDVFNFVTNIRRKRP-----YMVQTKEQYAFIYGAVLEDLLW
.|.||.|.     .  .|...||.||.||||  ||. .  .. .    .. ..   .  .|.|||      .... ||| ||. |.|| | .
flefieea.....dkggpvlvHCkaGkgRtgtfvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
0049260 (Phosphotyrosine protein) phosphatases II 666-856 2.5e-37 123.2 In-house 2-143 (152) alignment 
Range on Protein: 666-856
Range on HMM: 2-143/152.0
IPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWpnkqgdsvkfgnfkvelesleactggvkrkmtmrkgddcrtvtQFH
|. . . ...|| |||   ...|||||... ..||| |.|.|.| .|.|| ||.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVahakktRMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
.. ||| |||...  || ... ..    .  .| ..||||||||||... .. .       . |.....|  .|.|||..|....|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0046846 (Phosphotyrosine protein) phosphatases II 652-859 4.9e-37 122.7 In-house 6-169 (176) alignment 
Range on Protein: 652-859
Range on HMM: 6-169/176.0
IDDIPHSDYFNASYIPSFdnekAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVkfgnfkvelesleactggvkrkmt
. . ...|| ||..| .     ..|| |||   .. ||..|......|.. ..|...| ...|| .|||  .. ..                        
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

mrkgddcrtvtQFHFTEWPDKGVPKHtSSLLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVISIDsvvaHAKKTRMVDVFNFVTNIRRKRP-YMVQTKE
           |.... ||| ||| . . ||.......    .  .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYAFIYGAV
|| |.| ..
Qyrflyefe
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 630-866 1.1e-36 121.4 In-house 43-274 (288) alignment 
Range on Protein: 630-866
Range on HMM: 43-274/288.0
NLKKNRYKNILPYDSARVKLEviDDiPHSdYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKF
|  ..||.|.   | .||||.  || |.  | .|  ..|  ...  | .| |  . .. .|.|. ...|  | |...| |  | |  .|.| |.|.....
nptrdryenlprcditrvkls..dd.pdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GNFKVELESLEactGGVKRKMT------MRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVkadhGQYTHPLIIHCSAGVGRTGVVISIDSVVAHA
| .            .... ..       ..|..   | . |. ||.|.|||.   | |.... .     ....|...|.|||||||| .| |  ..  .
grlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialesl

KKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWR
. .  . . ..... | .|   .||. || ...  |||.|| .
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_ptpA1_pd Subfamily ptpA1 625-815 7.6e-36 118.7 In-house 42-248 (418) alignment 
Range on Protein: 625-815
Range on HMM: 42-248/418.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSfDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQG
 .|. |  |||| |||| . .||.|. |.|   ||| || ||      | .|..|||   .. |||||||.. .  | |...  |  .||| .|||.. |
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

DS---------VKFGNFKVELES-LEA-CTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQY------THPLIIHCSAGV
             || . |||   ..      . |.. .    . | .||...  |||. .| ||  . .... .   . |         |.|.||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGVVIS
|||| . .
grtgtfct
0041856 (Phosphotyrosine protein) phosphatases II 918-1109 1.1e-35 118.3 In-house 1-176 (182) alignment 
Range on Protein: 918-1109
Range on HMM: 1-176/182.0
NHPKNRYGNNIPLERNRvildspEHDYINASYIKGVHCT--FMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNdkS-Q--NDKASHTVTQYQFHGWPKHGS
|..|||| . .| ...|        |||||... | . .  |  || ||. || ||. |. ... .|||.|.  . .   ..  ....||....|| || 
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgv

DQqsgARSLLKLIRAVKGstnskKEFSILVHCLSGAGRTGVFCTATECIAQvaegnSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLHTEKY
      ..||..|..|.      ..  .||||  | ||||... |  .. .     .|.....||..|  |...|.| . | |......|.|.  |.
pd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0051082 (Phosphotyrosine protein) phosphatases II 656-859 3.4e-35 116.2 In-house 1-149 (151) alignment 
Range on Protein: 656-859
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdnekaYIASQGPnaasMDDFWRMVWQENVTTIAMVTKLQEGDkiKCRQYWPNKQgdsvkfgnfkvelesleactggvkrkmtmrkg
|.|||.|.||. ..     ...|.||    ..||..........|| ......| .  .| .|.|. .                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ddcRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdhgQYTHPLIIHCSAGVGRTGVVISIDSVVAHakktrmVDVFNFVTNIRRKRPYMVQTKEQYAFI
   ..|...... ||| |.| .. ..|.|.... .   .  .|...|||||.||||... .. .  .      |...  .  .|.|||..||...|. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YGAV
. |.
lfal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 755-899 6.5e-35 115.3 In-house 85-230 (440) alignment 
Range on Protein: 755-899
Range on HMM: 85-230/440.0
GDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYA
| ..||. |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||.|..||.. .||..  .|.|.|. ..| .|| |||| ||||
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSVDGNGRSKMSKEFQ
|.. |||| ||  .|||     |.......       .| . .||.
fvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 625-863 1.7e-34 114.1 In-house 30-270 (285) alignment 
Range on Protein: 625-863
Range on HMM: 30-270/285.0
AQKEINLKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFD-NEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQ
.  | |   ||| ..   . .|| |.  |     ||  ||..     .. .||..|||   .. |||.|..||... . |.  | ||   ||  |.|.| 
tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

GDSVKFGNFKVELES--LEACTGGVKRKMTMRKGDDCRTV----TQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQyTHPLIIHCSAGVGRTGVVISID
|. ||||.... |     || .| .   .|. . .|. .      . .   |||.  |. .  .... | ||    .  .|. .|||||||||  .. ||
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgid

SVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
    .  .   ..... | ..|  |   ||.. |. |.|  ..| .
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0044763 (Phosphotyrosine protein) phosphatases II 641-858 3e-34 113.6 In-house 1-166 (178) alignment 
Range on Protein: 641-858
Range on HMM: 1-166/178.0
PYDSARVKLEVIDDIPHSDYFNASYIPSFdnekAYIASQGPnaasmDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGdsvkfgnfkvelesle
|.|  ||.|. . ... |||.|||.|  .     |..|..|      |..........|.| ..|. .|. ..|| .||| . |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

actggvkrkmtmrkgddcrtvTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHakktRMvDVFNFVTNIRR
                      |.... .|| |||  .. .|.|.. ... . .  .| ..||||||||.|... .. .  .    .. .... .  .|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

KRPyMVQTKEQYAFIYGA
.|| .|.. .|. ..|  
rRp.ivpnpgqlrqLyef
subfamily_PTPRD_pd Subfamily PTPRD 990-1110 3e-34 113.6 In-house 170-287 (564) alignment 
Range on Protein: 990-1110
Range on HMM: 170-287/564.0
SQNDKASHTVTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKGSTnSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
 .... |..|.|..|  || ||  ..   .|||.||| |. .. ....  |.||| .| ||||.|..   .. .. | . |||.|.||.||..|   |||
kkkssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt

GEEYAFIYDVIREYLHTEKYE
 | |.||...| |.|.  . |
eeQYiFiheailealacgnte
PTPc_DSPc_SM00012 760-861 1.3e-33 110.7 In-house 1-105 (105) alignment 
Range on Protein: 760-861
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVVISIDSVVAHAKKT-RMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
||...|.|.|||.|||....|.|.....||  . . .  .|...||||||||||... .| .. . .|. . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 632-858 4.8e-33 109.2 In-house 52-277 (301) alignment 
Range on Protein: 632-858
Range on HMM: 52-277/301.0
KKNRYKNIlPYDSaRVKLEVIDDIPHSDyFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGN
.|.||... | .     .|||.|        | .||.  . . .||.|||  ....||| |. | .| .|.|...  |  . ||..| | | ..... | 
dkhryptv.PckP.stavevivdGkrvP.ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

FKVELESLEACTGGV--KRKMTMRKG---DDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqyTHPLIIHCSAGVGRTGVVISIDSVVAHAKKT
||..... |        ||.. ..      . |||| . ..||.|.||||    | .... ||       .|...|||||.||.   |. . .  . .  
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarevead

RMVDVFNFVTNIRRKRPYMVQTKEQYAFI-YGA
. ... . . ..| .|   |||..|  ..  |.
ptieltealkhlrehrwngvqtnsqlywmtlGt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 991-1108 7.2e-33 109.0 In-house 172-287 (305) alignment 
Range on Protein: 991-1108
Range on HMM: 172-287/305.0
QNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
..|| |.||.|||.  || ||  |.  | |||.||. |. . .. |. ..||||  | ||||||..    . .. . ..||.|. .| ||  ||. ||| 
dedkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

EEYAFIYDVIREYLHTEK
..| |..|.. |.... .
dqYvflhdaldelitcgd
0051429 (Phosphotyrosine protein) phosphatases II 942-1106 6.9e-32 106.6 In-house 4-227 (272) alignment 
Range on Protein: 942-1106
Range on HMM: 4-227/272.0
HDYINASYIKGVhCT------FMTTQMPLPTTVSDFWSMvLKYKPSTIVMLNDKS---------------------------------------------
 .||||....|  .       .  ...||| |. ||| .  ... .|||.| . .                                             
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

-------------QNDKAsHTVTQYQFHGWPKHGSDQQSgARSLLKLIRAvkgstnskkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVD------
             ....| ..|.......|| ||  |..  ..||.|...         .  .|||| .| .|||... .  ....| .   ||      
dyilrellltlllsagea.revmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLHT
  ....|..||| |...||| | |.|.|....|.| .
lyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 630-856 9.5e-32 104.8 In-house 52-283 (310) alignment 
Range on Protein: 630-856
Range on HMM: 52-283/310.0
NLKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNK----QGD
...|||| ...  |..||||. ||   . ||  | |. .    ...| ||||   .. |||||..||   .| .. |  |  . ||  |||         
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

SVKFGNFKVELESLEACTGGVKRKMTMRKGDD------CRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqythPLIIHCSAGVGRTGVVISIDSV
 ..  |.    | .| |   |         |.         |.  .. .|||.|||      .      .  ||    | ..|||||..|..||....  
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalklk

VAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
. ....   ||. . .|.....|   .||. || .| 
idkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 991-1110 1.1e-30 101.8 In-house 169-286 (318) alignment 
Range on Protein: 991-1110
Range on HMM: 169-286/318.0
QNDKASHTVTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
.. ..| .| ||..  || .|. ...   |||.|.| |.   .....  |.||| .| ||||||..    . .... . ||.|||||.||  |   ||| 
teeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

EEYAFIYDVIREYLHTEKYE
. | |||||. |.|.. . |
dqyefiydvllealasgdte
0049772 (Phosphotyrosine protein) phosphatases II 914-1105 1.4e-30 102.5 In-house 42-281 (314) alignment 
Range on Protein: 914-1105
Range on HMM: 42-281/314.0
LAPDNHPKNRYGNNIPLErNRVILDS---PEHDYINASYIKGVhCTFMTTQMPLPTTVSDF----------WSMVL--KYKPSTIVM-------------
  . |. |||| . .| . |||||..     .|||||||..|. ..|. || ||. || ||          |.|||  .... .|||             
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LNDKSQN-------------------DKASHTVTQYQFHGWPKHGSDQQSGARSLLKLIRAVkgstnsKKEFSILVHCLSGAGRTGVFCTAT
        |.. . |                   .. .... .|  . .| .. .  .  ...|..|...      .|.  .|||| .| ||||.|..| 
daAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaa

ECIAQVaegnSVDIFQTVKMLRADRM-----QSVQTGEEYAFIYDVIREYLH
 .. .      |.. ......|. |.      .... |.| ||.....||| 
ylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
DSPc_SM00195 991-1104 1.6e-30 101.7 In-house 152-262 (263) alignment 
Range on Protein: 991-1104
Range on HMM: 152-262/263.0
QNDKASHTVTQYQFHGWPKHGSDqqSGARSLLKLIRAVKGSTNSKkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
.... ...|||||...||.|| .  . ..|.|.|.|||| |.... .  |.|||  | ||||.|.|.  .. ...|.. ||||..||.||  |...||| 
egkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

EEYAFIYDVIREYL
|.|.|||..| ||.
eqYlfiyeaileyi
PTPc_SM00194 991-1104 1.6e-30 101.7 In-house 152-262 (263) alignment 
Range on Protein: 991-1104
Range on HMM: 152-262/263.0
QNDKASHTVTQYQFHGWPKHGSDqqSGARSLLKLIRAVKGSTNSKkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
.... ...|||||...||.|| .  . ..|.|.|.|||| |.... .  |.|||  | ||||.|.|.  .. ...|.. ||||..||.||  |...||| 
egkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

EEYAFIYDVIREYL
|.|.|||..| ||.
eqYlfiyeaileyi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 884-995 1.7e-29 97.9 In-house 17-132 (297) alignment 
Range on Protein: 884-995
Range on HMM: 17-132/297.0
TSVDGNGRSKMSKEfQSLCPdpPASQTRSGLAPDNH---PKNRYGNNIPLERNRVILD----SPEHDYINASYIKGVHCTFMTTQMPLPTTVSDFWSMVL
| |. | .... .| . ||.  |.......   ...   .|.|| | .| ...||.|     .|. ||.|||..||..  ..||||| ..|| ||| |||
tlvqknrhtdvfse.eflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvl

KYKPSTIVMLNDKSQNDKA
....||||||||....|| 
deqvstivmlnddnerdkk
Y_phosphatase Protein-tyrosine phosphatase 991-1100 2.6e-29 97.7 Pfam-A 127-233 (235) alignment 
Range on Protein: 991-1100
Range on HMM: 127-233/235.0
QNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTnSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
........|.|.....||.||  ..  ..|||.|||.|. |. ..|. ...|||  |.||||.|...  .. |. ....||..|.||.||. |...||. 
keesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

EEYAFIYDVI
|.|.|.|..|
eqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 991-1100 2.6e-29 97.7 In-house 127-233 (235) alignment 
Range on Protein: 991-1100
Range on HMM: 127-233/235.0
QNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTnSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
........|.|.....||.||  ..  ..|||.|||.|. |. ..|. ...|||  |.||||.|...  .. |. ....||..|.||.||. |...||. 
keesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

EEYAFIYDVI
|.|.|.|..|
eqYiflykai
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 903-994 4e-29 96.2 In-house 30-127 (392) alignment 
Range on Protein: 903-994
Range on HMM: 30-127/392.0
PDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDK
|.|........  ..| .||||.|..|....||.|    |.|..||.|||||.....  .....|.| .....|||.||.. ...||.|...  . ||
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdk
0043147 (Phosphotyrosine protein) phosphatases II 940-1098 7.6e-29 96.0 In-house 3-155 (172) alignment 
Range on Protein: 940-1098
Range on HMM: 3-155/172.0
PEHDYINASYIKGVHCT--FMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDK-SQNDKASHTVTQYQFHGWPKHGSDqqsGARSLLKLIRAVKGSTNSKK
. .|||||||.......  |  || ||. |..||| |. ... ..||.|..     .. .... ||....|| ||      .. ||.... ..   . ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp...llellleflefidellalsp

EFSILVHCLSGAGRTGVFCTATECIaqvaegNSVDIFQTVKMLRADRMQSVQTGEEYAFIYD
.  .||||  | ||||... |  ..       .......|...|. |...||. . | |.|.
ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyy
subfamily_PTPRK_pd Subfamily PTPRK 992-1102 1.1e-28 95.0 In-house 168-275 (314) alignment 
Range on Protein: 992-1102
Range on HMM: 168-275/314.0
NDKASHTVTQYQFHGWPKHgsDQQSGARSLLKLIRAVKGSTNSkKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
. .. ..| |.|| |||.|  |    |..||||.| || |..  ..  |.|||..||||||.|.. .  .  . . . ||.|..|| ||. ..  |.| |
gqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvetee

EYAFIYDVIRE
 | |||||| |
qykfiydvile
0036282 (Phosphotyrosine protein) phosphatases II 942-1098 1.2e-28 95.4 In-house 2-164 (174) alignment 
Range on Protein: 942-1098
Range on HMM: 2-164/174.0
HDYINASYIKGVHCT--FMTTQMPLPttvsdFWSMVLKYKPSTIVMLNDKSQN-------------DKASHTVTQYQFHGWPKHGSDQQSGarsLLKLIR
.||||||.......|  .  .| ||.     || |. ... .|.|||..  ..             .  .... ||.. .|| ||    |    ||....
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi...llefvk

AVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAeGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYD
.|.   .....  .||||  | ||||... |  .. .    . ||....|..||  |...||| . | |.|.
fveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 632-860 1.5e-28 94.7 In-house 21-256 (290) alignment 
Range on Protein: 632-860
Range on HMM: 21-256/290.0
KKNRYKNILpYDSARVKLEVIDDIPHSDYFNASYIpSFDNEKAYIASQGPNAAS-------MDDFWRMVWQENVTTIAMVTKLQEGDKI----KCRQYWP
...|... |    .|| |..      .||. |... .. |  . |..| | ..        . .|| |. ||.|. . |. . .| ..      | .| |
mdqRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

NKQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDC-RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKadhgQYTHPLIIHCSAGVGRTGVVISIDSV
.. |...||....|.  | |.  .  .|..... .|.   |||   . .| .  |...| .||. |. ||    ... | |.||  |. |  .. .|.  
esvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilg

VAH-AKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
    |...  | . . . ..|..|  ........||.  ...
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 991-1106 2.3e-28 94.3 In-house 179-292 (298) alignment 
Range on Protein: 991-1106
Range on HMM: 179-292/298.0
QNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
.. . ...| | .|  || .|  ..  |.|.|.|.| |. |..  .. ...|.| .| ||.| |.     . .| . ..||.||.||.||..|...||| 
kkeekerevrqlhftsWpdkgvpen..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

EEYAFIYDVIREYLHT
|.|.|||... |.|..
eqYvfiyeavlealds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 991-1108 3.1e-28 93.7 In-house 172-287 (319) alignment 
Range on Protein: 991-1108
Range on HMM: 172-287/319.0
QNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
...  . .|...|.  || |.  ..  |.|||.|.. .. |.. ...  | |||  |.|||| |..    . .| | . .|.|.||..||. |   ||. 
ssevetRevkhfqyteWpdhdvPek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp

EEYAFIYDVIREYLHTEK
| | |||....|.... .
eqYkfiyealleaveagd
subfamily_PTPRA_pd Subfamily PTPRA 990-1105 7.2e-28 92.4 In-house 184-297 (330) alignment 
Range on Protein: 990-1105
Range on HMM: 184-297/330.0
SQNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEfSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
....|.|  |.|. |..||. |   .  .. .|||...||   . . . .| ||| .|.|||| |..    ...|   . ||.|..|| ||. | | |||
atrekksrlvrqfhftswPdvGvPfe..piGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqt

GEEYAFIYDVIREY-LH
 | | ||| |..|| |.
deqyefiykvlleyyly
subfamily_egg_pd Subfamily egg 623-860 7.6e-28 92.1 In-house 33-267 (307) alignment 
Range on Protein: 623-860
Range on HMM: 33-267/307.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDkiKCRQYWPNK
| | .. ||.| | | .   ||.|||||.       |.  | ..        .| .| |   ..|||||||.||.|  | |.|  .| .  .|  |||. 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpka

QGDSVKF--GNFKVELESLEACTGGVKRKMTMRK-GDDcrtVTQFHFTEWpdKGVPKHTSSLLKFIkEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSV
. ||...  |....|   ..  .  . |   ..  | |     . .   |  .|  ...| .   . .|     . ..| ....  || .......|.  
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehw..qgdvnnssdvyspl.rvlrklrnlskpvvvqdilGvskaatlvaieia

VAHAKK--TRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
. .  .  .    | . |  .|..|.. |..  .| |.|  ||
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_CG42327_pd Subfamily CG42327 607-791 1.1e-27 91.6 In-house 7-193 (319) alignment 
Range on Protein: 607-791
Range on HMM: 7-193/319.0
FFEEFHDLPgpDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVT
 .|||.|||   .  .. .      .|.|. |..|   .|| |. | | ... |..|||.  .|. .  |||.| .   |  ||||.||. .  .|  .|
vaeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

KLQEGDKIKCRQYWPNKQGD--SVKFGNFKVELESLEACTGGVKRKMTMRK--GDDCRTVTQFHFtEWPDKGVPKHTSSLLKFIKEVKAD
.|.|    .| .|.| |..      .|...| |   |.    .   . ...  .. .| .| . . .|.. .|| . ..|.  . ||.. 
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
PTPc_DSPc_SM00012 998-1101 2.6e-27 90.4 In-house 1-104 (105) alignment 
Range on Protein: 998-1101
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKGSTNSKK-EFSILVHCLSGAGRTGVFCTATECIAQVAEG-NSVDIFQTVKMLRADRMQSVQTGEEYAF
||..|...|||.||  ..|   |.|.|.|||| ..| .. . ...|||  |.||||.|...  .. |. .. ..|||||.||.||  |...||| |.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

IYDVIR
.|... 
lyrall
DSPc_SM00195 894-994 3.3e-27 90.8 In-house 2-108 (263) alignment 
Range on Protein: 894-994
Range on HMM: 2-108/263.0
MSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKG--VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLN
...||..|    . ..|...  . |. |||| | .| ...||.|...|    .|||||.||||     ..  ||.|||.||.||| ||.. | ..||||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

DKSQNDK
. ..|.|
eeeengk
PTPc_SM00194 894-994 3.3e-27 90.8 In-house 2-108 (263) alignment 
Range on Protein: 894-994
Range on HMM: 2-108/263.0
MSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKG--VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLN
...||..|    . ..|...  . |. |||| | .| ...||.|...|    .|||||.||||     ..  ||.|||.||.||| ||.. | ..||||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

DKSQNDK
. ..|.|
eeeengk
0046846 (Phosphotyrosine protein) phosphatases II 934-1104 6.1e-27 89.9 In-house 4-173 (176) alignment 
Range on Protein: 934-1104
Range on HMM: 4-173/176.0
RVILDSPEHDYINASYIKGvhCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKAS---------HTVTQYQFHGWPKHGSDQQsgaRSLLKL
|.. . .  |||||..| |  . . .|| ||| |. ||. |..... ...|.|..  . .. .             ||....|| ||  .    . ||.|
rllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl...elllel

IRAVKGSTNSKkeFSILVHCLSGAGRTGVFCTATeciaQVAEGNSVDIFQTVKMLRADRM-QSVQTGEEYAFIYDVIREYL
.....   ...    .||||  | ||||... |      .  .. ..........|. |. ..||| | | |.|......|
lefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 991-1106 5.3e-26 86.3 In-house 130-244 (250) alignment 
Range on Protein: 991-1106
Range on HMM: 130-244/250.0
QNDKASH-TVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
.. ||.. .| |..|  ||  |  ..  |.. |.|.. |. | .  ..  ..|.| .| ||.| |..    . .. . . ||.|. .|.||.||...|..
kakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphaves

GEEYAFIYDVIREYLHT
 | | |.| .| ..| .
leqyvfvyeiilkalds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 867-994 2.4e-25 84.2 In-house 2-130 (319) alignment 
Range on Protein: 867-994
Range on HMM: 2-130/319.0
NTLIPVIHFTDHLQDLHTsvdgNGRSKMSKEFQSLCPDPPAsQTRSGLAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVH--CTFMTT
.| |.| .. ..|. |..    .|  .. |||. |    .  ...|   ..|..|||| | .. .| ||.|    .... ||||||.| | .    |. |
dteievqeLkerlkalas....tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiat

QMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDK
| || .|..||| || ... |..|||.. ... |
qaPlentiedfWrmvWeeessivvmltklveklk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 993-1102 3.2e-25 83.8 In-house 171-277 (288) alignment 
Range on Protein: 993-1102
Range on HMM: 171-277/288.0
DKASHTVTQYQFHGWPKHGsdQQSGARSLLKLIRAVKGSTNSKkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEE
.|   ..||||. .|| ||      .. ||.|.| || . ...    |.|||  | ||||.| ..   | .| | . .|.. ||. ||  |.. ||| . 
kkteleitqyqylaWpdhg..vPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkq

YAFIYDVIRE
| |||.|. .
Yefiyevlls
subfamily_PTPRB_pd Subfamily PTPRB 992-1109 6.4e-25 82.8 In-house 174-290 (293) alignment 
Range on Protein: 992-1109
Range on HMM: 174-290/293.0
NDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGST-NSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
..|....|.||.|  || ||  ..  ...||...|.|. .. .....  |.||| .| ||||.| .  . . .. | . |||| .|  || .|.. ||| 
kekeerkvrqyhftsWpdhgvPek..tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqte

EEYAFIYDVIREYLHTEKY
..| ||.... ..|.... 
kqYifihqcvldllrkkee
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 884-994 6.9e-25 82.7 In-house 13-129 (288) alignment 
Range on Protein: 884-994
Range on HMM: 13-129/288.0
TSVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLK
.  . ..|. .|.|..|| .    ...  |  . |..|||| | .|.. .|| |.     .. ||||||||.| .   ....|| ||. || ||| .|  
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YKPSTIVMLNDKSQNDK
.| ||||||..  ...|
nktstivmltelveggk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 870-994 1.2e-24 82.1 In-house 5-138 (298) alignment 
Range on Protein: 870-994
Range on HMM: 5-138/298.0
IPVIHFTDHLQDLHTSVDGNGRSKMSKEFQSLCPDPP---ASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGVHC--TFMTT
| . ... .|| | .    .. .....||| |        . ... . .|.|. |||| . |.|.  ||.| .     | ||||||.... .   .|..|
ieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiat

QMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDK
| ||..||.||| || ... .|||||..  . ||
qaPltetvedFWrmvteedigtiVmltnleeldk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 633-864 1.3e-24 81.4 In-house 46-277 (312) alignment 
Range on Protein: 633-864
Range on HMM: 46-277/312.0
KNRYKNILPYDSARVKLEVIDDIphsdYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGdSVKFGNF
 ||| ||  .|  |  |   ...    |  | ..    . . ....|||   .   ||...     |.| ... . |    || .|  .  |  |.. . 
lnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdledh

KVELESLEAC--TGGVKRKMTMRK--------GDDcRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqytHPLIIHCSAGVGRTGVVISIDSVVAH
.|  |.       |  | |.| |         |..   . .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.|..| 
rvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmiaa

AKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLL
 .. |  .| .    .|. |   |..  || .   .||| | 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 630-860 1.4e-24 81.0 In-house 51-282 (302) alignment 
Range on Protein: 630-860
Range on HMM: 51-282/302.0
NLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYI--PSFDneKAYIASQGPNAASM---DDFWRMVWQENVTTIAMVTKLQEGDKiKCRQYWPNKQG
|||||. ...  .|| .||||   |    .| ||| .  |..   .  | .| |.  |    ..|||||.||..... .. . .| .|    ...|.|.|
nlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRT---VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVA
| ...|.. |     |   . ..| .     ..|     ..  ..| |..| ||.. ..| | ...| | . . .....|    |.|| |....   .| 
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

HAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVL
. .|   . . . |..|| .|| .|.. .||...| |.|
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 870-992 1.4e-24 81.8 In-house 2-126 (318) alignment 
Range on Protein: 870-992
Range on HMM: 2-126/318.0
IPVIHFTDHLQDLHTsvdgNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILD----SPEHDYINASYIKGVH--CTFMTTQMP
|.| .. .|.. |..    .|. ..|.|.. | ...  . .   | | |. |||| | .. .. || |.    ... |||||.|| | .   ... .| |
isvedleshvrrlre....sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaP

LPTTVSDFWSMVLKYKPSTIVMLNDKSQN
|| |..||| ||   . ..|||| .....
lpetieDfWrmvWeqnsavivmltqeeer
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 991-1106 2.1e-24 80.9 In-house 172-285 (290) alignment 
Range on Protein: 991-1106
Range on HMM: 172-285/290.0
QNDKASHTVTQYQFHGWPKHGsDQQSGARSLLKLIRAVKgSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
....|...|||||.  |...| . .  . .|| . . .|     . . ||.|||  . ||..|||.|.  | ..     .|.|| .| .|  ...|||| 
nsagakqsvtqyqitnwdstg.kvtnpqtillvieemyk.tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv

EEYAFIYDVIREYLHT
..| .|.... .||..
qqyqgifqivltylds
subfamily_PTPRG_pd Subfamily PTPRG 991-1110 5e-24 79.4 In-house 177-293 (563) alignment 
Range on Protein: 991-1110
Range on HMM: 177-293/563.0
QNDKASHTVTQYQFHGWPKHGSDQQsgarSLLKLIRAVKGSTNSKKE-FSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
.. .  ..|.||..  || ||. ..    || .|| ..| |.  |.|   |.||| .|.||||...  .  . |. . |.|..|...|..|| |   |||
kqcdteklvrqyhytkWPdhgvPeh....slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

GEEYAFIYDVIREYLHTEKYE
 |.| |..|.. | . ... |
eEqYiflhdalleaiaskete
0048076 (Phosphotyrosine protein) phosphatases II 717-859 5.6e-24 79.9 In-house 1-139 (145) alignment 
Range on Protein: 717-859
Range on HMM: 1-139/145.0
QYWPNKQGDSVKFGNFKVELESLEACTGGVKR--KMTMRKGDDCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVI
.|||..  ... .|.. . |.  . .  |...   .|. . .  |...|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||...
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

SIDSVVAhakktRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAV
 .. .       . |.... .  .|..||..|.. .|. |.| ..
aaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
0051082 (Phosphotyrosine protein) phosphatases II 942-1100 6.5e-24 79.7 In-house 3-149 (151) alignment 
Range on Protein: 942-1100
Range on HMM: 3-149/151.0
HDYINASYIKGVhctFMTTQMPLPttvsDFWSMVLKYKPSTIVMLNDKSQN-------DKASHTVTQYQFHGWPKHGSDQQ-SGARSLLKLIRAvkgstn
 ||||.||. |    .  ...||.    ||. .. ... .|||.|...  .        .....|.......|| .| ..    ....|.|...      
sdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld......

sKKEFSILVHCLSGAGRTGVFCTATECIAQvaegnsVDIFQTVKMLRADRMQSVQTGEEYAFIYDVI
 ||.  .|||| .| ||||... .  .. .      |.........|. |. .||. ... |.. ..
.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
0049260 (Phosphotyrosine protein) phosphatases II 955-1098 7.3e-24 79.6 In-house 9-144 (152) alignment 
Range on Protein: 955-1098
Range on HMM: 9-144/152.0
CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKA-SHTVTQYQFHGWPKHGSDQQSGARSLLKLIRAVKgstNSKKEFSILVHCLSGAGRTGV
  |. || |.| |..||| |. ... .|||||.. . ..|   .   ||... || ||  . |     | |.       . .|.  .||||  | ||||.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgt

FCTATECIaqvaegNSVDIFQTVKMLRADRMQSVQTGEEYAFIYD
.. |  ..      . |.....|...|. |...|.. . . |.|.
lvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 991-1107 1e-23 78.8 In-house 167-281 (287) alignment 
Range on Protein: 991-1107
Range on HMM: 167-281/287.0
QNDKASHTVTQYQFHGWPKHGSDQQsGARSLLKLIRAVKGSTNSkKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTG
..... ..|.|||.  |...|  ..  . .|| . . .|    .  . ||.|||  . ||...|| |   | .. .   .|.|| .|  |  ...|||| 
nkagdkqqvkqyqitnWdstgkvte.pqtillvieemyktqrkr.gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtv

EEYAFIYDVIREYLHTE
|.| ||.|.. |||.. 
eqykfindivleyldsf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 672-856 2.6e-23 77.3 In-house 4-197 (199) alignment 
Range on Protein: 672-856
Range on HMM: 4-197/199.0
EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMT----MRKGDDCRTVTQFHFT
.. |||.| |   .| |||.|||.     | ||   |   .     |||  .  . |.|.. |  ... .    .   .            | .... ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsSLLKFI---KEVKADHGQY-THPLIIHCSAGVGRTGVVISIDSVV-AHA-KKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
 | .|  |. .  .. |.   .||   . |    |.|.||| | | ||| ...|  | .|   || .||.|.    .|. |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 679-861 3.7e-23 76.4 In-house 97-286 (302) alignment 
Range on Protein: 679-861
Range on HMM: 97-286/302.0
QGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEA----CTGGVKRKM-------TMRKGDDCRTVTQFHFT
  |   ... .| .. | ||. .. .... |... || .|. .| |. .|||.. |.  |..      |   . |.       . .| .  .||  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

EWPDKGVPKHTSSLLKFIKEVKAdhgqYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
 |||.| ||.. . |. .|  ..    | . ...|||||||||| ...|   .   .| .. |. . |. .|. |   ||...|  ..   |  
awpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_PTPN23_pd Subfamily PTPN23 889-996 3.8e-23 76.7 In-house 12-124 (288) alignment 
Range on Protein: 889-996
Range on HMM: 12-124/288.0
NGRSKMSKEFQSLCP--DPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKGVHC---TFMTTQMPLPTTVSDFWSMVLKYKPSTI
.|.... |.|. |    |  | ..   .|  .  |||. . .| ..||| |.. . ||||||..|..     .|..|| ||..|..|||.|| . | |.|
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLNDKSQNDKAS
||| .|.. .| .
Vmllskeelgkpk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 672-856 4.3e-23 76.5 In-house 3-196 (198) alignment 
Range on Protein: 672-856
Range on HMM: 3-196/198.0
EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEACTGGVKRKMT----MRKGDDCRTVTQFHFT
.. |||.| |   .. |||.|||.     | ||   |   .     |||  .  . |.|.. |  ... .    .   .            | .... ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsSLLKFI---KEVKADHGQY-THPLIIHCSAGVGRTGVVISIDSVV-AHA-KKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
 | .|  |. .  .. |.   .||   . |    |.|.||| | | ||| ...|  | .|   || .||.|.    .|. |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_CG7180_pd Subfamily CG7180 990-1106 5.2e-23 76.1 In-house 173-292 (296) alignment 
Range on Protein: 990-1106
Range on HMM: 173-292/296.0
SQNDKASHTVTQYQFHGWPKHGSDQQSgARSLLKLIRAVKGSTNSK----KEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQ
 | .    .|...|.  |. . .   | . .|..|.| |.   .      .|  ..|..  ||.|.||....  .. .| . . ||.|. ||.|| .| |
kqvkaetRivklfqlteWeledkvPls.tnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpq

SVQTGEEYAFIYDVIREYLHT
 |.. ||| .||||. |.. .
LvenveeYkyiYdvlleavlc
subfamily_PTPN12_pd Subfamily PTPN12 990-1106 6.3e-23 76.1 In-house 163-279 (290) alignment 
Range on Protein: 990-1106
Range on HMM: 163-279/290.0
SQNDKASHTVTQYQFHGWPKHGSDqqSGARSLLKLIRAVKGSTNsKKEFSILVHCLSGAGRTGVFCTATECIAQVA---EGNSVDIFQTVKMLRADRMQS
 ...|.|..|.|.... || ||    |.| |||.||..|.   . ...  ..||| .| ||||. ..      ..      ...|.|. |  || .|   
veaqkesrkvyqfhYtaWPDhgvP..ssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraal

VQTGEEYAFIYDVIREYLHT
||| | | ..|  . |....
vqtkeqyelvykavaelvqk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 995-1105 6.4e-23 76.4 In-house 176-289 (325) alignment 
Range on Protein: 995-1105
Range on HMM: 176-289/325.0
ASHTVTQYQFHGWPKHGSDQQSG-ARSLLKLIRAVKGS--TNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
 . .| |.|. .|.  | ...     |.|.|. ||.    .|.|    ||||| .| |||||| .    .|.| |  .||||. || ||.|| . |.| .
etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

EYAFIYDVIREYLH
.| .||. . |.. 
qyiliyealveaym
Y_phosphatase Protein-tyrosine phosphatase 918-993 2.2e-22 75.0 Pfam-A 1-80 (235) alignment 
Range on Protein: 918-993
Range on HMM: 1-80/235.0
NHPKNRYGNNIPLERNRVIL-DSPE-HDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQND
|. |||| . .| ...|| | .|.. .|||||.|.||   . .|. ||.||. |..||| ||...| ..||||..  ...
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekg
Y_phosphatase Protein-tyrosine phosphatase 918-993 2.2e-22 75.0 In-house 1-80 (235) alignment 
Range on Protein: 918-993
Range on HMM: 1-80/235.0
NHPKNRYGNNIPLERNRVIL-DSPE-HDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQND
|. |||| . .| ...|| | .|.. .|||||.|.||   . .|. ||.||. |..||| ||...| ..||||..  ...
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 995-1107 2.3e-22 74.3 In-house 150-267 (270) alignment 
Range on Protein: 995-1107
Range on HMM: 150-267/270.0
ASHTVTQYQFHGWPKHGSDQQSG----ARSLLKLIRAVKGSTNSKKE-FSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
 .. .. .... || ||  ....    ...|||..|||. |......   .||||  | ||||.. .   ..  . | ..||. . .. || |||. ||.
eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqh

GEEYAFIYDVIREYLHTE
 |.|.|.| ...|| .. 
peqyeflykavveyaerr
0048179 (Phosphotyrosine protein) phosphatases II 718-856 2.4e-22 74.7 In-house 2-138 (144) alignment 
Range on Protein: 718-856
Range on HMM: 2-138/144.0
YWPNKQGDSVKFGNFKVELESLEACTGGVKRKMTMRKGD----DCRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVV
..|..  ... .|.. . |.  . .  |..   ... .       |...|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||..
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtl

ISIDSVVahakKTRmVDVFNFVTNIRRKRPYMVQTKEQYAFIY
. .. ..    | . ..... .  .|..||..|.. .|. |..
vaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 632-731 2.8e-22 73.9 In-house 49-164 (350) alignment 
Range on Protein: 632-731
Range on HMM: 49-164/350.0
KKNRYKNILPYDSARVKLE----VIDDIPH----SDYFNASYIP----SFDNEK--AYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQ
 ||||||||||. .||||.      | . |    .|| ||.|.     | . .    ||| |.|    .|||.... . .|. | ..|...| .  || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNKQGDS--VKFGN
||.. . |   ||. .
YWqegsydditvklas
subfamily_PTPRG_pd Subfamily PTPRG 870-993 3.3e-22 73.4 In-house 1-129 (563) alignment 
Range on Protein: 870-993
Range on HMM: 1-129/563.0
IPVIHFTDHLQDLHTsvdgNGRSKMSKEFQ--SLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS-PE----HDYINASYIKGVH--CTFMTT
.|| .|. |. .||.    .|  ..|.||.    .  .   .. .  .|.|. |||| | .. .| || | . |.    .|||||.||.| .    |..|
vpvkefakhvaslha....dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiat

QMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQND
| ||..|. ||| |.   . ..|||. .  .. 
qgplkdtfddFWrmiWeqnvaiivmitnlverg
subfamily_eak_pd Subfamily eak 623-870 3.6e-22 73.2 In-house 45-312 (332) alignment 
Range on Protein: 623-870
Range on HMM: 45-312/332.0
TVAQKEINLKKNrYKNILPYDSARVKLEVIDdIPHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNK
.....  ....|   .|.|||   |.|       .  | ||| .   .  . || .  ..   .  ||.|| ...  .| .. .  | .  |  .|.|.|
setarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

QGDSVKFGNFKVELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKHTS--SLLKFIKEVKAD-------------HGQYTH-----PLIIH
  . .||| ..||  .         |.. ..||..   |  ...  | .  .||     .| | .||| .                .| |       || 
treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiq

CSAGVGRTGVVISIDSVVA--HAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLLWRNTLI
.. |  |.|| . || ..    .||. .  | ...  .. || . | .. |..||| .||. || ||  .
sarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
subfamily_PTPN6_pd Subfamily PTPN6 990-1108 3.7e-22 73.7 In-house 179-301 (306) alignment 
Range on Protein: 990-1108
Range on HMM: 179-301/306.0
SQNDKASHTVTQYQFHGWPKHGSDQQSGAR-SLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQV---AEGNSVDIFQTVKMLRADRMQ
 ...| ...| ||.|. || ||  .. ||  ..|. ... . ....... .|.||| .| |||| |      . ..        .|| ..||..|. | .
kkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsg

SVQTGEEYAFIYDVIREYLHTEK
 ||| . | |.| .|..|..|.|
lvqteqqykfvykaikkyietkk
subfamily_PTPRB_pd Subfamily PTPRB 870-988 4.3e-22 73.5 In-house 7-127 (293) alignment 
Range on Protein: 870-988
Range on HMM: 7-127/293.0
IPVIHFTDHLQDLHTSVDgngrSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVHC--TFMTTQMP
| . .|..|......  |     ..|.|...|       .. .  .. |. |||| | .| . .|| |    |... |||||.||.| ..   |..|| |
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPTTVSDFWSMVLKYKPSTIVMLND
||.|| ||| ||.. | |.|||| .
lpetvddfWrmvwekkssiivmltq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 990-1108 6.2e-22 72.7 In-house 181-297 (301) alignment 
Range on Protein: 990-1108
Range on HMM: 181-297/301.0
SQNDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
 ..||.|..|.|.|   ||..|  ..   |  |. |  |   ...     ..|||  . .|.||.|. .  . |.     ||.|| .| .|  ..  |.|
vksdksswdvlqlqvtdWpqdGvvre..prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT

GEEYAFIYDVIREYLHTEK
 | | .||||| .||. ..
Leqytsiydvidmylqlns
subfamily_Ptp69D_pd Subfamily Ptp69D 990-1106 1.3e-21 72.0 In-house 175-288 (307) alignment 
Range on Protein: 990-1106
Range on HMM: 175-288/307.0
SQNDKASHTVTQYQFHGWPkhGSDQQSGARSLLKLIRAVKGSTNSKkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
| . ..|. |.||.. ||.   |     ||.|||||. |.   . . .  |.|||  |.||.|.| . .  . |. . ..||||.||| || .|   || 
sgevedsrkvvqyhytgWk..DskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

GEEYAFIYDVIREYLHT
 | | |.|  . .| . 
leqYvflyralldyssy
subfamily_PTPN9_pd Subfamily PTPN9 992-1105 2.3e-21 71.1 In-house 168-291 (297) alignment 
Range on Protein: 992-1105
Range on HMM: 168-291/297.0
NDKASHTVTQYQFHGWPKHGSDQQSGA-RSLLKLIRAVKGST---------NSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRA
... | .|| .|| .|| .|  ... .   .|. .|  ....            ..  |.||| .| |||| |.|   |.... | . ||...|||.||.
kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrt

DRMQSVQTGEEYAFIYDVIREYLH
 |  |.|| | |.| |  . ||  
qrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 997-1102 2.4e-21 71.0 In-house 175-277 (315) alignment 
Range on Protein: 997-1102
Range on HMM: 175-277/315.0
HTVTQYQFHGWPkhGSDQQSGARSLLKLIRAVKGSTNSKKeFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFI
..| |...  ||   ..    . .|..||| ||   ...   .|.||| .| |||| |.|    . |.   | .|... .. .|. |.. ||. |.| ||
revvqlhytswp..dmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfi

YDVIRE
||.. |
ydalle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 893-994 2.6e-21 71.1 In-house 24-130 (325) alignment 
Range on Protein: 893-994
Range on HMM: 24-130/325.0
KMSKEFQSLCPDPPASQTRSGlAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVML
 ...||. | .| . ... ..  |.|  |||. | ..|...||.|    |.|. |||||||..      .|...|.||..|. |.| .|| .. | .|.|
gfahefgllpsddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl

NDKSQNDK
|   ....
neldlgkd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 996-1106 3.1e-21 70.7 In-house 160-270 (274) alignment 
Range on Protein: 996-1106
Range on HMM: 160-270/274.0
SHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEF--SILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEY
...|. | .  || | | ..  |..||.|.. |. | .....   ...||| .| ||||.| ... .. |. | . ||....|  || ||   ||| | |
ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqy

AFIYDVIREYLHT
 .|. .. .||. 
elihralclylkr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 992-1107 6.5e-21 69.7 In-house 165-279 (281) alignment 
Range on Protein: 992-1107
Range on HMM: 165-279/281.0
NDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVA-EGNSVDIFQTVKMLRADRMQSVQTG
..  . .|.| ..  || ||  ..  .. ||.  ..|.  |..|.. ....|| .| ||||.. .    . .|. | ...|. ..|. || .|.  ||| 
esgetreveqlaytaWPdhGvPat..tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

EEYAFIYDVIREYLHTE
  |.|.| .. ..|. |
vqyefvykavldaldke
0044763 (Phosphotyrosine protein) phosphatases II 929-1104 1.2e-20 69.4 In-house 1-171 (178) alignment 
Range on Protein: 929-1104
Range on HMM: 1-171/178.0
PLERNRVILDSPEH----DYINASYIKGVhcTFMTTQMPlpttvSDFWSMVLKYKPSTIVMLNDKSQNDKASHTV-------TQYQFHGWPKHGSDQ-QS
||.|.||.|...|.    ||||||.| .    ..... |     .|.. .. ... ..||.|..   . . ..          ||.. ..| ||  .  .
pldrtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdlle

GARSLLKLIRAVKgstnSKKEFSILVHCLSGAGRTGVFCTATECIAQvaegnSVDIFQTVKMLRADRMqSVQTGEEYAFIYDVIREYL
  . ....|...     ..|.  .||||  | ||.|... |  .. .     ...... ....|. |.  |.. . . ..|.. ...|
hflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 915-997 1.6e-20 68.4 In-house 6-94 (250) alignment 
Range on Protein: 915-997
Range on HMM: 6-94/250.0
APDNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKASH
 |.|. |||| . |.|.  ||.| . .     ||||||...| .   .|..|| ||..|. ||| |||..| .|||||.. ....|  |
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyh
subfamily_PTPN6_pd Subfamily PTPN6 876-990 1.9e-20 68.1 In-house 10-133 (306) alignment 
Range on Protein: 876-990
Range on HMM: 10-133/306.0
TDHLQDLHTSVDGNGRSKMSKEFQSLCPDP--PASQTRSGLAPDNHPKNRYGNNIPLERNRVIL---DSPEHDYINASYIK----GVHCTFMTTQMPLPT
 .. ..|. . .  ... ...||..|  .      . . |  |.|. |||| | .| . .||||   . |..|||||.|||    | ......||  |.|
eqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclet

TVSDFWSMVLKYKPSTIVMLNDKS
||||||.||.. .   |||.  . 
tvsdFWrmvwqensrvivmttkev
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 667-863 3e-20 67.4 In-house 27-221 (255) alignment 
Range on Protein: 667-863
Range on HMM: 27-221/255.0
PSFDNEKAYIASQgpnaaSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESleACTGGVK--RKMTMRKG--DDCRTVT
|. |...  . |      ..| |.... | . ....|.. ..| .. || .|.| .. .  |. . .|      . .  |   ...|   |     .||.
Pekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqytHPLIIHCSAGVGRTGVVISIDSVVA------HAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIY
 .... |..|  |. .  .|. .| |.       .....|||.|.||.   . ...|        .  .|  .|  ......| ||.  ..|  | ||  
hysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

GAVLEDL
  ||. .
lmvldlv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 993-1104 4e-20 67.4 In-house 181-292 (319) alignment 
Range on Protein: 993-1104
Range on HMM: 181-292/319.0
DKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTN-SKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
 |    .||. | |||..|  ..  .  |..|.. |.  |.  ... .|.||| .|.|||||. .    . .. | . ||....|. || .| . ||   
ekdirkitqfhflGwpdvGvpdy..psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

EYAFIYDVIRE-YL
.| |||  . | .|
qykfiysalleehl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 993-1104 6.5e-20 66.8 In-house 145-256 (284) alignment 
Range on Protein: 993-1104
Range on HMM: 145-256/284.0
DKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTN-SKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
 |   ...|. | |||..|  ..  .  |..|.. |.  |.  ... .|.||| .|.|||||. .    . .. | . ||....|. || .| . ||   
ekdirkirqfhflgwpdvgvpdy..psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

EYAFIYDVIRE-YL
.| |||  . | .|
qykfiysalleehl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 994-1102 1.5e-19 65.0 In-house 159-264 (283) alignment 
Range on Protein: 994-1102
Range on HMM: 159-264/283.0
KASHTVTQYQFHGWpkHGSDQQSGARSLLKLIRaVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEY
|..  .. ||. .|     ..|.   ||.|. . |.   . .|.  |.||| .| |||.||..|.  . ..     ||.|..||..| .||  ||| . |
kstlllahyqvidW..leygeqaiinslvkfnk.vislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqy

AFIYDVIRE
 ...... |
klvhelvle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 628-864 1.7e-19 64.6 In-house 45-280 (303) alignment 
Range on Protein: 628-864
Range on HMM: 45-280/303.0
EINLKKNRYKNILPYDSARVKLEviddipHSDYFNASYIpSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQgDSV
  |..|||. ...  | ..|||        | |  |||.  .| .|  | .| | . .  |||.|. ...|  . ..    | ||.     .|..| | .
vknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq.dfl

KFGNFKV---ELESLEACTGGVKRKMTMRKGDDCRTVTQFHFTEWPDKGVPKH-TSSLLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVVISIDSV--
|| .  .   |.  .|   | | . ... .||    .   |. .|| . .| . .. ..| | ....   .|.  .| .    .|.||.|    ...   
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

VAHAKkTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDLL
  |..    .|. . . |.|  | . ||   |....|  . | .|
slhse.qasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_PTPN13_pd Subfamily PTPN13 992-1105 2.7e-19 64.5 In-house 161-270 (273) alignment 
Range on Protein: 992-1105
Range on HMM: 161-270/273.0
NDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNskKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
. ..|. |.. .|  || ||  ..  | .||.... |.   .  ..  |.||| .| ||.|.. |    .  ..  ...|. ..|. ||  |   ||| .
esgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd

EYAFIYDVIREYLH
 | |.| .| | |.
qyifvykailevlk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 869-994 5.3e-19 63.2 In-house 1-130 (290) alignment 
Range on Protein: 869-994
Range on HMM: 1-130/290.0
LIPVIHFTDHLQdlhtSVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILD-SPEH-----DYINASYIKG--VHCTFMTT
|||| .|.....        .|.... ..|..|       ..  ||...|...||. | .. . ||..|   ..|     .||||.||||   .  .. |
lipvdkfgefva....nghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiat

QMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDK
| |.. |. |||... . | . |||| .  ...|
qgpvsntlvdFWkliwqekvtiivmltniieegk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 890-994 5.5e-19 63.2 In-house 18-125 (287) alignment 
Range on Protein: 890-994
Range on HMM: 18-125/287.0
GRSKMSKEFQSLCP-DPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVML
|.   .. |. |   .    .   ..|..|..|||. . .. . .||.|   ..|||||..|.| .    |. .. |.  |. .|| .. . ....||||
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivml

NDKSQNDK
 .. .||.
cqekende
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 891-992 7.5e-19 63.0 In-house 21-126 (305) alignment 
Range on Protein: 891-992
Range on HMM: 21-126/305.0
RSKMSKEFQSLCPDppASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSP----EHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIV
 ... ....||. .   ...  |    |. |||. ....|. .|.||       ..|||||||..| .   .....| ||..||.||| .....|.||||
dkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLNDKSQN
|| .  ..
mltklveg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 891-988 9.7e-19 62.8 In-house 33-138 (319) alignment 
Range on Protein: 891-988
Range on HMM: 33-138/319.0
RSKMSKEFQSLCPDPP--ASQTRSGLaPDNHPKNRYGNNIPLERNRVILDSP----EHDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPST
..|.  ||. .|  ..  | || . | ..|  |||..| .. ..|.| |.        ||||||...|      ....| ||. |. ||| |. .|. ||
ltklevefrracklgvnladqtfanl.dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLN-D
||.|  |
ivlltkd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 995-1104 1.2e-18 61.6 In-house 87-194 (440) alignment 
Range on Protein: 995-1104
Range on HMM: 87-194/440.0
ASHTVTQYQFHGWPKHGSDQQSGarSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYA
 |.|. ||...||| .|  . .|   .||.|. |. | .   .  .|||| .|||||||  .    . ..   . .|||  .. .| .| | ||| |.||
esrtlkqyhyqgwpdkgvpkfag..pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIYDVIREYL
|..... | |
fvheavlegl
subfamily_PTPN14_pd Subfamily PTPN14 996-1106 1.8e-18 61.6 In-house 182-298 (300) alignment 
Range on Protein: 996-1106
Range on HMM: 182-298/300.0
SHTVTQYQFHGWPKHGS-DQQSGARSLLKLIRAVKGSTNSKKE-----FSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
  ||   |.  ||.||  .  .|  | |. ...|.  |||..|       .||||. |.|||||  ..   || .  ....|| .....||  ||  |||
ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt

GEEYAFIYDVIREYLHT
   | |.|.|. .||. 
laqYkfvYkvlikylkn
subfamily_PTPN23_pd Subfamily PTPN23 994-1105 3e-18 60.6 In-house 168-281 (288) alignment 
Range on Protein: 994-1105
Range on HMM: 168-281/288.0
KASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKG---STNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSV-DIFQTVKMLRADRMQSVQT
.| ..|.  |.. ||..|  .     .||... .|.    ... | .  ..|||..| ||||||.     .... .|| . || | |. ||..|  .||.
davksvshlqltsWpelGvPas..PetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqe

GEEYAFIYDVIREYLH
 |.. | |... |. .
keqlkfsyeavleaar
subfamily_PTPN12_pd Subfamily PTPN12 909-994 3.4e-18 60.5 In-house 31-122 (290) alignment 
Range on Protein: 909-994
Range on HMM: 31-122/290.0
QTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDK
.| .| .. |  |||| . .| . .|| |      .. |||||..||||.  .... .| |||.|..||| |. ... . .||.  .  ..|
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk
subfamily_Ptp69D_pd Subfamily Ptp69D 892-994 4.8e-18 60.3 In-house 22-130 (307) alignment 
Range on Protein: 892-994
Range on HMM: 22-130/307.0
SKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVM
  . ||...|       .|. .   .|  |||| . .. ...||.|       . ||||||.|||   . .|.. | |. .|. ||| |.   .  .|||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LNDKSQNDK
| . .. ..
lsnlteknr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 789-863 7.1e-18 59.5 In-house 222-295 (297) alignment 
Range on Protein: 789-863
Range on HMM: 222-295/297.0
KADHGQyTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
.|.. .   .|..||||||||.|||.  | ..|  .| |. ||  ... .| .|. .||| ||. ..| |||. |
raempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 897-989 7.1e-18 60.1 In-house 3-103 (284) alignment 
Range on Protein: 897-989
Range on HMM: 3-103/284.0
EFQSLCPDPP--ASQTRSGLaPDNHPKNRYGNNIPLERNRVILDSP----EHDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLN-
||. .|  ..  . || . | ..|  |||.|. .. ..|.| |.        ||||||.|.|      ...|| ||. |. ||| |. .|. ||||.|  
efrracklgvngtdqtfanl.dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltk

DK
||
dk
subfamily_PTPRK_pd Subfamily PTPRK 917-990 9.7e-18 59.0 In-house 42-121 (314) alignment 
Range on Protein: 917-990
Range on HMM: 42-121/314.0
DNHPKNRYGNNIPLERNRVILDSPE----HDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKS
.|. |||.|. .. .| ||.| . .     |||||..| . .    |. || ||. || ||| .|.... ..||||..  
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 917-995 1.3e-17 58.8 In-house 48-132 (315) alignment 
Range on Protein: 917-995
Range on HMM: 48-132/315.0
DNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKA
 |. |||| | |. .. || |      |. ||.||..|.|      ....| |....| ||| .| ... ..||||..  ...| 
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekr
subfamily_PTPRA_pd Subfamily PTPRA 894-989 1.7e-17 58.3 In-house 34-135 (330) alignment 
Range on Protein: 894-989
Range on HMM: 34-135/330.0
MSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILD----SPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLN
. .||..|   |  .        .|. |||. | .| . .||||      .| ||||||.|.| .   .|...| |.  || ||| |. ..| .||||| 
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

DK
. 
el
subfamily_PTPN3_pd Subfamily PTPN3 990-1101 3e-17 57.5 In-house 164-272 (280) alignment 
Range on Protein: 990-1101
Range on HMM: 164-272/280.0
SQNDKASHTVTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKGSTNSkKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQT
 .. | .....| |.  || ||  ..|   ..|.... |.   .. ||  ..||| .| |||||. .   ..| . . ..| . . |...|  |.  |||
dketkeerkilqlqylaWpdhgvPdds..adflefvervrklrsg.keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqt

GEEYAFIYDVIR
 . | |. . | 
asqykfvCeail
subfamily_PTPN9_pd Subfamily PTPN9 879-987 4.5e-17 57.0 In-house 3-117 (297) alignment 
Range on Protein: 879-987
Range on HMM: 3-117/297.0
LQDLHTSVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGV--HCTFMTTQMPLPTTVSDFW
...| . |  .|.. .|||.. .   |.. .      . |  |||| . . ... || | .    .. |||||... |   . .|..|| ||. ||||||
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfW

SMVLKYKPSTIVMLN
 ||   .  .|||  
rmvWeqevlvivmtt
subfamily_PTPRN_pd Subfamily PTPRN 993-1102 5.9e-17 56.3 In-house 183-290 (297) alignment 
Range on Protein: 993-1102
Range on HMM: 183-290/297.0
DKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSkKEFSILVHCLSGAGRTGVFCTATECIAQVAEG-NSVDIFQTVKMLRADRMQSVQTGE
 . . ||||. |  ||..|   .  |.|||.. | |  |    .  .|.||| .|||||||..     ..... | . .||  |.. || .| . |.| .
tsetrtvtqfhflswpeegvPas..aksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd

EYAFIYDVIRE
.. |.. .. |
qfefaltavae
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 889-991 7.3e-17 56.4 In-house 12-120 (281) alignment 
Range on Protein: 889-991
Range on HMM: 12-120/281.0
NGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPST
|  . . .|...|      . ...  |..|  |||| | .  .  || .    .. . |||||....|..    ...|| |.|... .|| ||...| |.
ndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

IVMLNDKSQ
|||.  . .
ivmvtreie
subfamily_hpo-7_pd Subfamily hpo-7 683-861 8e-17 56.0 In-house 44-225 (263) alignment 
Range on Protein: 683-861
Range on HMM: 44-225/263.0
AASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNKQGDSVKFGNFKVELESLEActGGVKRKMTM----RKGDDCRTVTQFHFTEWPDKGVPKHT
   .| |.... | . ....|..  .| .. || .|.| .. .  |. | .|           ...   .     .    .||... .. |..|  |. .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

SSLLKFIKEVKADhgqytHPLIIHCSAGVGRTGVVISIDSVVA------HAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLE
 . |. .| ..       ..|..|||.|.||.     ...|        .  .|  .|  ......| .|.  ..|  | ||    ||.
reilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_PTPN3_pd Subfamily PTPN3 893-989 1.3e-16 55.4 In-house 16-118 (280) alignment 
Range on Protein: 893-989
Range on HMM: 16-118/280.0
KMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIK----G--VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVML
.. ..|. |    |  ..     |.| .|||| . .| .  ||.|.. | |||||.|..    .  .   ...|| ||..|..||| || . | |.||||
avlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

NDK
 . 
ttl
subfamily_CG42327_pd Subfamily CG42327 793-858 1.4e-16 55.1 In-house 244-310 (319) alignment 
Range on Protein: 793-858
Range on HMM: 244-310/319.0
GQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKT-RMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGA
 .   ||..||| ||||||.||. |  . . ... | ||. . |  .|| |   |.|||||.|||  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 894-988 1.6e-16 55.1 In-house 8-105 (267) alignment 
Range on Protein: 894-988
Range on HMM: 8-105/267.0
MSKEFQSLCPDPPASQT-RSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
. |||. .    . |.|    .| .|. .||. .|.| . .||||   |..||||||..| .   .|. || ||  |..||. .. ..| ..||.|  
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 992-1104 2.7e-16 54.1 In-house 169-279 (439) alignment 
Range on Protein: 992-1104
Range on HMM: 169-279/439.0
NDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
. .  .|| |...  ||..    |  |  .|...||.. . ....   ..||| .| ||||   .   .. |.   | |||   ||.|| .| | ||.  
ttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc

EYAFIYDVIREYL
.| |||. . | .
qyvfiynavledi
subfamily_ptpA1_pd Subfamily ptpA1 893-993 3.3e-16 54.0 In-house 22-127 (418) alignment 
Range on Protein: 893-993
Range on HMM: 22-127/418.0
KMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVHC-TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLN
|. .||. |      |.|  |    |  |||| | .|... || |    |    ||||| || | .   |. || ||| |..||| || . .   ||||.
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmls

DKSQND
 .|.| 
resenc
subfamily_PTPN1_pd Subfamily PTPN1 909-988 3.4e-16 53.8 In-house 23-104 (290) alignment 
Range on Protein: 909-988
Range on HMM: 23-104/290.0
QTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIK--GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
.||.   | |...||| .  | .  |..|.. . |||||| ..   ..  .. || ||| ||. || || . |  ..|||| 
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk
0048076 (Phosphotyrosine protein) phosphatases II 972-1103 4e-16 54.5 In-house 22-142 (145) alignment 
Range on Protein: 972-1103
Range on HMM: 22-142/145.0
WSMVLKYKPSTIVMLndKSQNDKASHTVTQYQFHGWPKHGSDQQ-SGARSLLKLIRAVKGStnsKkeFSILVHCLSGAGRTGVFCTATECIAqvaegNSV
. .  ...  |.. |   |  .  .....||.. .|| ||  .  .  ...|..|...  .   .    .||||  | ||||... |  ..      ..|
lellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealke...g..gpvlVHCsaGvgRtgtlvaaylmll.....lgv

DIFQTVKMLRADRMQSVQTGEEYAFIYDVIREY
.........|. |...|.. . . |.|....|.
sleealelvrsqrpgavpnpgqlrflyefelel
subfamily_PTPN13_pd Subfamily PTPN13 893-991 4.6e-16 53.9 In-house 12-113 (273) alignment 
Range on Protein: 893-991
Range on HMM: 12-113/273.0
KMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHdYINASYIKGV----HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
. ..||. |    |  ....|   .|. |||| | .| .. ||.|..    |||||.||      . ... .| |||.||.||| ||   | . |.|.  
qPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

KSQ
. .
eke
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 915-989 4.6e-16 53.7 In-house 25-107 (274) alignment 
Range on Protein: 915-989
Range on HMM: 25-107/274.0
APDNHPKNRYGNNIPLERNRVIL-----DSPEHDYINASYIKGVH---CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDK
 . .. |||| . .| |. ||.|     .... .|||| |||| .    ... || |||.||.||| |. . . . |||| . 
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl
0048179 (Phosphotyrosine protein) phosphatases II 973-1098 5.8e-16 54.0 In-house 23-139 (144) alignment 
Range on Protein: 973-1098
Range on HMM: 23-139/144.0
SMVLKYKPSTIVMLNDKSQNDKASHTVTQYQFHGWPKHGSDQQ-SGARSLLKLIRAVKGstnskKEFSILVHCLSGAGRTGVFCTATECIaqvaEGNsVD
 .  |.. .|.. |...  ..   ....||.. .|| ||  .  .  ...|..|...       ..  .||||  | ||||....|  ..    . . ..
ellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk....klg.ls

IFQTVKMLRADRMQSVQTGEEYAFIYD
........|. |...|.. . . |...
leealalvrsrrpgavpnpgqlrfLle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 906-988 8.1e-16 52.7 In-house 21-108 (283) alignment 
Range on Protein: 906-988
Range on HMM: 21-108/283.0
PASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSPEHDYINASYIK-----GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
|  ..    | .|..|||. . .| ...|| |.|  .|||||..|           .. .| ||  || ||| || . | ..||||  
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 893-987 8.5e-16 52.6 In-house 11-112 (287) alignment 
Range on Protein: 893-987
Range on HMM: 11-112/287.0
KMSKEFQSLCPDPPASQTRSGLAPD--NHPKNRYGNNIPLERNRVILD-SPEH--DYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVM
.. ||.. |. |  .|      | .  .  ||||.. .|.. .||.|   .|.  ||||| |. . .   .|...| |...|| ||| .||. . .....
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LN
. 
mt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 800-863 1e-15 51.8 In-house 2-65 (69) alignment 
Range on Protein: 800-863
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |  ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 884-994 1.3e-15 51.9 In-house 7-124 (301) alignment 
Range on Protein: 884-994
Range on HMM: 7-124/301.0
TSVDGNGRSKMSKEFQSLCPDPPaSQTRSGLAPDNHPKNRYGNNIPLERNRVILDSP------EHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMV
| |  .   |.......|    .  ..  ||  .|.. ||. |. ... ||.||         ...|||||||.|.     |. .| |.  |. ||| ..
thvaakhsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrli

LKYKPSTIVMLNDKSQNDK
...||..|||. .. .. |
wqekpvsivmvtnlkegtk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 880-994 1.4e-15 51.8 In-house 15-133 (290) alignment 
Range on Protein: 880-994
Range on HMM: 15-133/290.0
QDLHTSVDGNGRSKMSKEF-QSLCPDPPASQTRSGLAPDNH--PKNRYGNNIPLERNRVIL-DSPEHDYINASYIKGVHCTFMTTQMPLPTTVSDFWSMV
. . ..|   .  ...||. . | |  |. .    .   |    |||| . .  .. |||| |  . ||. | |.||.. .|. || .|  || |.| ||
ekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmv

LKYKPSTIVMLNDKSQNDK
|. | ..|||| .  .. |
lqekvaaivmlceliedGk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 994-1101 1.4e-15 52.2 In-house 130-236 (237) alignment 
Range on Protein: 994-1101
Range on HMM: 130-236/237.0
KASHTVTQYQFHGWPKHGSDQQSGArsLLKLIRA-VKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEE
|    . ||||  ||..|  ||. |  ||.. .  .. |    .    ..|| .| ||||.|      . |  | . |||.. |. .  ||   .|| ..
kevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

YAFIYDVIR
| ||...| 
yvfihqtil
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 800-863 2.6e-15 50.5 In-house 1-64 (69) alignment 
Range on Protein: 800-863
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |  ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 997-1100 2.7e-15 51.2 In-house 136-236 (239) alignment 
Range on Protein: 997-1100
Range on HMM: 136-236/239.0
HTVTQYQFHGWPKHGSDQQSGArsLLKLIRAV-KGSTNSKKEFsiLVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAF
. | ||.|  || .|  | . |  .| | | . | |    . .  ..|| .| |||| |      . |  . ..||||. || .| || . ||| |.| |
ryvyqyhftvwpdkgvpqyata..vlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvf

IYDVI
|.  .
ihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 997-1099 3e-15 51.1 In-house 137-236 (239) alignment 
Range on Protein: 997-1099
Range on HMM: 137-236/239.0
HTVTQYQFHGWPKHGSDQQSGArsLLKLIRAV-KGSTNSKKEFsiLVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAF
. | ||.|  || .|  | . |  .| | | . | |    . .  ..|| .| |||| |      . |  . ..||||. || .| || . ||| |.| |
ryvyqyhftvwpdkgvpqyata..vlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvf

IYDV
|.  
ihla
subfamily_PTPN14_pd Subfamily PTPN14 892-994 3.7e-15 50.7 In-house 23-132 (300) alignment 
Range on Protein: 892-994
Range on HMM: 23-132/300.0
SKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDSP---EHDYINASYIK----GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIV
.|. .|.. . .    ... ..  |.| .|||. . .| | ||| | .    ...||||| ||    | . .....| ||..|| ||| ||   . . ||
gkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MLNDKSQNDK
|| .. .. |
mlteeeedgk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 760-860 1.3e-14 48.7 In-house 216-341 (350) alignment 
Range on Protein: 760-860
Range on HMM: 216-341/350.0
TVTQFHFTEWPDKGVPKHTSSLLKFIK-------EVKA-DH--GQYTHPLIIHCSAGVGRTGVVISIDSVVA-------HAKKT-------RMVD-VFNF
 | |...  |.| ..  .  |.|. ..       .  |  |   . . |...||||||||||.....||..          |.        .. | ..  
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VTNIRRKRPYMVQTKEQYAFIYGAVL
| ..|..|  |||...|. ||| |.|
vnelrkqrismvqnldqfifiYeall
subfamily_CG42327_pd Subfamily CG42327 1026-1103 1.7e-14 48.2 In-house 235-314 (319) alignment 
Range on Protein: 1026-1103
Range on HMM: 235-314/319.0
RAVKGST-NSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEG-NSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREY
  .   . . ..   . |||  |.||||.  ..   | .. |  .|||| |.|  .| || ..|.| | |.||| |. ||
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 994-1110 3e-14 47.8 In-house 173-286 (307) alignment 
Range on Protein: 994-1110
Range on HMM: 173-286/307.0
KASHTVTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKGSTNskkefSILVHCLSGAGRTGVFCTATECIAQVAEG-NSVDIFQTVKMLRADRMQSVQTGEE
. | |....|.. || .|  |     . . |. ||.. ||      ..||| .| ||.|   . .    .. .| |  |. . |. ||..|  ..||  .
qksrtiqhlqwenwpdrgvpqin..ltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq

YAFIYDVIREYL---HTEKYE
| ... |. ||.   . | ||
ylylhrvlleyflelyketye
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 632-739 6.7e-14 46.0 In-house 50-175 (349) alignment 
Range on Protein: 632-739
Range on HMM: 50-175/349.0
KKNRYKNILPYDSARVKLEVIDD--------------IPHSDYFNASYI--PSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDKIKC
 |||||.||||. .||||.                      || || |.  . .. || ||| | |  ...|||....  ..|  .  ... .| .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

RQYWPNKQ--GDSVKFGNFKVELESL
 .|| . .  .  ||. |      ..
diywqelsysnitvklqnsslyianv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 586-668 7.7e-14 45.8 In-house 3-85 (440) alignment 
Range on Protein: 586-668
Range on HMM: 3-85/440.0
RQPIPAAQFPAFVNKNRHTALFFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPS
..||  |.|  .|..|| .  | .|.  ||     |  .|    |  ||||.||| || .|| || .  .|.||| ||||| .
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_CG7180_pd Subfamily CG7180 908-992 1.9e-13 44.7 In-house 32-122 (296) alignment 
Range on Protein: 908-992
Range on HMM: 32-122/296.0
SQTRSGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQN
 . . ||  .|  |||. . .| . |||.|..     . |||||.|. .   .  .. |..|   || .||..| . . |..|.| .. . 
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 917-988 2.5e-13 44.8 In-house 2-78 (237) alignment 
Range on Protein: 917-988
Range on HMM: 2-78/237.0
DNHPKNRYGNNIPLERNRVILDSP--EHDYINASYIKGVHC---TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
.|. |||||| .  . .||.|  .  . |||||.|.||.     .....| || ..  ||| || . | | ||||  
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 918-988 8.2e-13 43.0 In-house 20-97 (270) alignment 
Range on Protein: 918-988
Range on HMM: 20-97/270.0
NHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKG---VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
..  ||| . .|  . ||.|..    ..  |||| |..|    ........ |||||...|| |... | ..|||. .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 993-1104 8.2e-13 43.0 In-house 152-259 (267) alignment 
Range on Protein: 993-1104
Range on HMM: 152-259/267.0
DKASHTVTQYQFHGWPKHGSdQQSGARSLLKLIrAVKGSTNSkkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEE
....| || | .. |      ..   . |. .. | .   |   .  ..|.|  | ||.| | ..   . .. . . .|||. .. .|  |.  |.| |.
nesahnvtlyyykkwnintn.nkpylkplfgil.aknqleng..nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtker

YAFIYDVIREYL
| .|.... || 
yiyihellaeya
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 993-1109 9.4e-13 42.4 In-house 179-288 (290) alignment 
Range on Protein: 993-1109
Range on HMM: 179-288/290.0
DKASHTVTQYQFHGWPKHgsdqqSGARSLLKLIRAVKGSTnsKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEE
.  .| .  ..   || .     | | | | |.| ..     |    . ||| .| |||| | .   ..  . .| ..|. ..|. ||  |..|||   .
sGkehklkhlkikswpdk.....svalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq

YAFIYDVIREYLHTEKY
|  . ... ..    ||
ylalveilldlGkdfky
subfamily_PTPRN_pd Subfamily PTPRN 890-993 9.9e-13 42.4 In-house 27-138 (297) alignment 
Range on Protein: 890-993
Range on HMM: 27-138/297.0
GRSKMSKEFQSLCPDPPASQTR-SGLAPDNHPKNRYGNNIPLERNRVILDS----PEHDYINASYIKGV---HCTFMTTQMPLPTTVSDFWSMVLKYKPS
 .....||...||      .|.  . |..|  |||. . .| . .|| |..     ..|||||| |      . ....|| ||..||.||| || .    
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMLNDKSQND
 ||.|   ....
vivnltrleeeg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 919-993 1.1e-12 42.3 In-house 48-142 (350) alignment 
Range on Protein: 919-993
Range on HMM: 48-142/350.0
HPKNRYGNNIPLERNRVILD------------SPEHDYINASYIKGV------HCTF--MTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQND
  |||| | .| |..||.|                 |||||.|.|           |  . || ||| || ||. ..|. |   |..|...  ..
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 992-1094 2.2e-12 41.3 In-house 176-271 (301) alignment 
Range on Protein: 992-1094
Range on HMM: 176-271/301.0
NDKASHTVTQYQFHGWPKHGSDQqsGARSLLKLIRAVKGSTNskkefSILVHCLSGAGRTGVFCtATECIAQ-VAEGNSVDIFQTVKMLRADRMQSVQTG
.. |..||| ||.. |...|  .  .   | .|.  || | .      |.||| .| ||.  |  .||..|. |   . ... ...| || .| ..||| 
gkfatrtvthyqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtn

EEYA
.   
sqly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1003-1109 3.6e-12 40.8 In-house 173-275 (285) alignment 
Range on Protein: 1003-1109
Range on HMM: 173-275/285.0
QFHGWPKHGSDqqSGARSLLKLIRAVKGStNsKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIRE
|   || . .     || ...| . ||   |  ||  | ||| .| |||  |     .  .. |   ..... |. .|| |.|.||.  .. |.| |. |
qvpwwpdqlap..edarpmielykwvkkv.n.pkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme

YLHTEKY
|.  |  
yfigegv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 880-988 4.9e-12 40.0 In-house 8-124 (439) alignment 
Range on Protein: 880-988
Range on HMM: 8-124/439.0
QDLHTSVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPD--NHPKNRYGNNIPLERNRVIL----DSPEHDYINASYIKGVHC--TFMTTQMPLPTTVSDF
|.    .| | .  ....|...    |  .  . || .  ...|||| .  ...  ||.|      |   |||| |||| .    ...||.|   |. ||
qehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WSMVLKYKPSTIVMLND
| .|.. | .||||| .
wrlviekktvtivmltn
subfamily_CG42327_pd Subfamily CG42327 891-993 9.6e-12 39.2 In-house 4-110 (319) alignment 
Range on Protein: 891-993
Range on HMM: 4-110/319.0
RSKMSKEFQSLcPDPPASQTrsGLAPDNHPKNRYGNNIPLERNRVILD----SPEHDYINASYIKGV---HCTFMTTQMPLPTTVSDFWSMVLKYKPSTI
|... .||. | |   |.     . .  ..|.|. | .||   ||.|.     ..  |..|||..|    .. ....|..|  . |||| .| . .  .|
redvaeefrdl.Pqliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMLNDKSQND
| | | |.. 
vqltdlselG
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 982-1097 1e-11 38.9 In-house 174-281 (302) alignment 
Range on Protein: 982-1097
Range on HMM: 174-281/302.0
TIVMLNDKSQNdKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKgstNSKKefSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRA
|. . |.| .. |  .||   .| .||.||. ..  | . |....  .     ||  ..||||  | |||| . .    |   .. .  |. . |. .|.
tveiknekkkk.kvkktvdilafsawpdhGapke..aytaldilkfce...sykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrq

DRMQSVQTGEEYAFIY
 |  .||. .   .. 
cryGavqdeqqliyll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 607-680 1.3e-11 38.5 In-house 25-95 (95) alignment 
Range on Protein: 607-680
Range on HMM: 25-95/95.0
FFEEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphSDYFNASYIPSFDNEKAYIASQG
| .||. ..     | ||   | |. |||. ||.|||..|| |    |   ||| || ..  .   ..|||.||
fdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 918-986 1.5e-11 38.8 In-house 35-106 (285) alignment 
Range on Protein: 918-986
Range on HMM: 35-106/285.0
NHPKNRYGNNIPLERNRVILDSPEHDYINASYIKG---VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVML
|   ||| .   .|  ||.|   ..||| ||...     . |..||| ||| |.|||| |. . | . ..||
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlml
subfamily_PTPN1_pd Subfamily PTPN1 993-1102 1.9e-11 38.2 In-house 158-269 (290) alignment 
Range on Protein: 993-1102
Range on HMM: 158-269/290.0
DKASHTVTQYQFHGWPKHGSDQQSGarSLLKLIRAVKGSTNSKK-EFSILVHCLSGAGRTGVFCTATECIAQVAEGN---SVDIFQTVKMLRADRMQSVQ
 . ....... .  ||  |  .  .  ..||..  |. |   ..     ..|| .| ||.| || .  |.... . .   |||| ...  ||  |.  .|
tqetreilhfhyttwpdfgvpespa..aflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

TGEEYAFIYDVIRE
| .   | |  | |
tadqlrfsylaile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 999-1112 1.9e-11 38.3 In-house 178-284 (312) alignment 
Range on Protein: 999-1112
Range on HMM: 178-284/312.0
VTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKgstNSKKefSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYD
. .||.  || ||  .     . |.|. |||   . ||   .. || .| |||| ..     || .      .. ..  .|| || .||..  .| .   
lnhyqwaswpdhgmpdsc..dtalrllsavk...kdkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalr

VIREYLHTEKYEQR
.. |.|...   .|
cvleflyskglykr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 994-1107 2.2e-11 38.1 In-house 165-280 (287) alignment 
Range on Protein: 994-1107
Range on HMM: 165-280/287.0
KASHTVTQYQFHGWPKHGSDQQ--SGARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGE
. .. | |...  ||...      . .|  |.  . .. . ....   ..||.  |.||.|.. .   .. .  .   ||. ..|  ||  |   ||.  
rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv

EYAFIYDVIREYLHTE
 . ..|. .  | .|.
qlrllyealvtyyktn
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 998-1111 2.2e-11 38.0 In-house 189-295 (305) alignment 
Range on Protein: 998-1111
Range on HMM: 189-295/305.0
TVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGStnskkEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSV-DIFQTVKMLRADRMQSVQTGEEYAFI
.| . |.  ||  |        . |.|. |..||     .  |.||| .| ||||   .    . ..|| ...  . . || || .|  |.|.  .| ||
svrhlqwtewpdrgvppc..kltslellsairgs.....kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi

YDVIREYLhTEKYEQ
. |. .|.  ||| .
hrvmlnyf.lekyke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 917-988 4.5e-11 37.0 In-house 47-121 (305) alignment 
Range on Protein: 917-988
Range on HMM: 47-121/305.0
DNHPKNRYGNNIPLERNRVILDSP-EHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
... |||| .   |..||| |..|  |.|| | |.        |. || ||  | .||| | |. |  .| || .
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 996-1108 5.5e-11 36.7 In-house 185-291 (305) alignment 
Range on Protein: 996-1108
Range on HMM: 185-291/305.0
SHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGStnsKKefSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQ-TVKMLRADRMQSVQTGEEYA
.. ||.| .  ||  |        ..|.|.   . |   |    | ||| .| ||||        . |. .|. ..  .  .. .| .| .|.|| ..| 
arkvthyhwidwpdrgvpaa..dlailellekarps...kg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqyl

FIYDVIREYLHTEK
|...|| .|.. .|
fvhqvilnyfrkkk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1042-1106 6.4e-11 36.4 In-house 2-66 (69) alignment 
Range on Protein: 1042-1106
Range on HMM: 2-66/69.0
VHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLHT
||| ||.|||| | .    .|..     ||||  |. .|  |   |   .|| ||.| . | |  
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1041-1105 7.9e-11 36.2 In-house 2-66 (69) alignment 
Range on Protein: 1041-1105
Range on HMM: 2-66/69.0
LVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYLH
.||| ||.|||| | .    .|..     ||||  |. .|  |   |    || ||.| . | | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 998-1111 1.1e-10 36.1 In-house 172-278 (288) alignment 
Range on Protein: 998-1111
Range on HMM: 172-278/288.0
TVTQYQFHGWPKHGSDQQsgARSLLKLIRAVkgsTNSKKefSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIY
 | .  .. |...|  ..    | |.|.  .    . .|   |.||.  |.|||| .      . ..   . . | . .. ||..|....||   | ...
ivkilhlleWdddgvPen..ylsplrllevl...kslqk..PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvh

DVIREYLHTEKYEQ
 .. |.|   ||..
rcvleelllkkykv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 902-993 1.2e-10 35.4 In-house 82-175 (244) alignment 
Range on Protein: 902-993
Range on HMM: 82-175/244.0
CPDPpaSQTRSGLAPDNHPKNRYGNNIPLERNRVILD--SPEHDYINASYIK--GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQND
 |||  |  .  . |.|  ||| |  .|.. ||| |   |    |||||..   |  . .. || ||  |  ||| |.|. .   .|.|    ..|
rpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 885-994 1.3e-10 35.3 In-house 20-133 (310) alignment 
Range on Protein: 885-994
Range on HMM: 20-133/310.0
SVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHpKNRYGNNIPLERNRVIL---DSPEHDYINASYIKG--VHCTFMTTQMPLPTTVSDFWSMVLKYK
. .  |   . |... |  .  .| |        | |||| . . |.  || |    |  .||| | |.|   .  ||. .| ||  |. ||| |... .
ateklgieglvkqyrkldakqdssltyeaykkymh.knrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqer

PSTIVMLNDKSQNDK
  .|..|   ... .
aesilllckvgeegr
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1002-1106 2e-10 34.6 In-house 186-287 (302) alignment 
Range on Protein: 1002-1106
Range on HMM: 186-287/302.0
YQFHGWPKHGSDqqsgaRSLLKLIRAVKGS--TNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDV
| .. |...         .  .||.....    ..| . ....    |||| |.| |..  . .. .|. . | ..|| .|..| ..|.. . |...| .
yvltnWkqkkvp.....vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyia

IREYLHT
.  |. .
lllyikk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 992-1101 2.3e-10 35.1 In-house 153-256 (290) alignment 
Range on Protein: 992-1101
Range on HMM: 153-256/290.0
NDKASHTVTQYQFHGWPKHgsDQQSGARSLLKLIRAVKgstnsKKEFSILVHCLSGAGRTGVFCTATECIAQVA-EGNSVDIFQTVKMLRADRMQSVQTG
.|.  .||| ....|| |     |   ..||.||. ||     ...  ..|||  |  |  .. .       .|   .|| . . .|.||  | . ... 
ddeeeftvtHsllkgWnkl..nvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsa

EEYAFIYDVIR
.|.||.  .| 
lelafvdagiv
subfamily_egg_pd Subfamily egg 938-1014 2.7e-10 34.4 In-house 68-134 (307) alignment 
Range on Protein: 938-1014
Range on HMM: 68-134/307.0
DspehDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNdkashtvtQ---YQfhgWPKHGSDQ
|    |.| | ..||     .|. .| ||  || ||| || . .   ||||. . ..        .   |    |||  || 
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes........erceyy...wpkaesds
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 919-995 4e-10 34.0 In-house 34-115 (297) alignment 
Range on Protein: 919-995
Range on HMM: 34-115/297.0
HPKNRYGNNIPLERNRVILD--SPEHDYINASYIK----GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNdKSQNDKA
  |||| . .  . .|| |    .|.||||| |.          .. .| || .|| ||| .| .    .|||.  | |.|  
lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva.klqedGr
subfamily_ptpA1_pd Subfamily ptpA1 997-1059 4.4e-10 33.8 In-house 186-251 (418) alignment 
Range on Protein: 997-1059
Range on HMM: 186-251/418.0
HTVTQYQFHGWPKHG-SDQQSGARSLLKLIRAVK--GSTNSKKEFSILVHCLSGAGRTGVFCTATE
. .||||. ||| |   |.    | ||. |   .     .| ..  |.||| .| |||| ||||  
rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 894-988 8e-10 32.8 In-house 13-114 (281) alignment 
Range on Protein: 894-988
Range on HMM: 13-114/281.0
MSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILDS--P---EHDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVML
. .||  |  |||.        | |  |||| |   |.  || |    |     ||| | ||.    .  .. || |   | .||| |. . . ..||||
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

ND
 .
cq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 889-988 1.5e-09 32.3 In-house 13-115 (307) alignment 
Range on Protein: 889-988
Range on HMM: 13-115/307.0
NGRSKMSKEFQSLCPDPPASQTRSGLApDNHPKNRYGNNIPLERNRVILDSP--EHDYINASYIKGV--HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIV
 | ...  ||. |.   | . |   .   |  |||| .    ...|...  .    ||| | |.        |. .| || .|. .||.|... |  ...
kgvqalvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MLND
|| .
mlck
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 993-1104 1.8e-09 32.0 In-house 112-221 (255) alignment 
Range on Protein: 993-1104
Range on HMM: 112-221/255.0
DKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKgstNSKkefSILVHCLSGAGRTGVFCTaTECIAQ-------VAEGNSVDIFQTVKMLRADRMQ
 |  |||. |...||... . ..  || .|.....|.   .||   |..||| .| ||.  |   .| . |        .|   .|  . .. ||  | .
kkkthtvkhysykGWieknaPel..areilnilkvvr...dsk...svvvhCstGiGrsaafvl.aelvyqkmirsldttetveldylslleelrskrkr

SVQTGEEYAFIYDVIREYL
...|  . ||   .. ...
aihtPlqlafsilmvldlv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1036-1100 2.1e-09 31.7 In-house 227-291 (297) alignment 
Range on Protein: 1036-1100
Range on HMM: 227-291/297.0
KEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDVI
..  .|||| .| ||.||   .   .|..  .   |.   ...||  | . ||| |.. ..||..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 761-861 4.4e-09 30.1 In-house 220-342 (349) alignment 
Range on Protein: 761-861
Range on HMM: 220-342/349.0
VTQFHFTEWPDKGVPKHTSSLLKFIKeVKAD-----------HGQYTHPLIIHCSAGVGRTGVVISIDSVVA-------HAKKT----RMVDVFNFVTNI
. |. . .|.| ..     |.|. .. || |           . . . .|..||||| |||||.. .|....       .  |      . |.  .. |.
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

-RRKRPYMVQTKEQYAFIYGAVLE
 |..|  |||   |. .|| |.|.
lrkqrismvqnlaqfiaiyealLk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 671-736 5.2e-09 29.9 In-house 234-295 (440) alignment 
Range on Protein: 671-736
Range on HMM: 234-295/440.0
NEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQegDKiKCRQYWPNKqGDSVKFGNFKVEL
. .|.||.| |  ... ||||.| . ...|| |. .|.  ||  |  ||| .   || || | |  
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywpvn.trsvtfgpftvgh
subfamily_hpo-7_pd Subfamily hpo-7 986-1096 6.9e-09 30.0 In-house 112-219 (263) alignment 
Range on Protein: 986-1096
Range on HMM: 112-219/263.0
LNDKSQnDKASHTVTQYQFHGWPKHGSDQQsgARSLLKLIRAVKGStnsKkefSILVHCLSGAGRTGVFCTaTECIAQ-------VAEGNSVDIFQTVKM
|.  ..  |  |||..|.. ||...   ..  ||. |........|   |   |. ||| .| ||.  |   .| . |        ..   .|  . .. 
lstlge.KkkthtvkhysykgWiekndpel..areilnilkvarns...k...slvvhcstGiGrsaafsv.aElvyqkmirsldttstveldylsLlee

LRADRMQSVQTGEEYAFI
||  | ....|    || 
lrssrkraihtPmqLafs
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 623-710 7.4e-09 29.6 In-house 30-122 (347) alignment 
Range on Protein: 623-710
Range on HMM: 30-122/347.0
TVAQKEINLKKNRYKNILPYDSARVKLEV-----IDDIPHSDYFNASYIpSFDN-EKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEG
|... | .|.||| |.    |..|| |           .   | |||.|  ||| .| || .| |   .. |||.||   .|| .  . . .. 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_PTPDC1_pd Subfamily PTPDC1 763-854 7.6e-09 30.3 In-house 84-167 (182) alignment 
Range on Protein: 763-854
Range on HMM: 84-167/182.0
QFHFTEWPDKGVPKHTsSLLKFIKEVKADHGQYthPLIIHCSAGVGRTGVVISIDSVvaHAKKtrmVDVFNFVTNIRRKRPYMVQTKEQYAF
 ..   |.| ||.  . ..|  .| |.    .    . .|| || |||||.|.   |  .||.   ..  . .. .| |||  .||.||  .
yvynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylv..yakr...ltaekaiklvrskrpksiqtreqvel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1035-1104 8.1e-09 29.6 In-house 260-344 (350) alignment 
Range on Protein: 1035-1104
Range on HMM: 260-344/350.0
KKEFSILVHCLSGAGRTGVFCTATECIA------QVAE-GN--------SVDIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
..  .||||| .| ||||...|    .       .. .  .           |...|. ||  |.. ||. . . |||. .. | 
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
fn3 Fibronectin type III domain 262-341 8.6e-09 28.6 Pfam-A 19-79 (85) alignment 
Range on Protein: 262-341
Range on HMM: 19-79/85.0
QWDPSSdIGDGPIVGYKIYVRSG-SNVvlskrvqppsivkntdvsVSKRSAENANEMvMYTVNGLEAGTTYSVQIAAIRDG
.|.|..  |.|||.||.. .|.  ..                   ..|.    ....  .|..||..||.|.....|. ..
sWsppk.dgggpitgYeveyrekggge..................ewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 956-994 1e-08 28.9 In-house 237-273 (440) alignment 
Range on Protein: 956-994
Range on HMM: 237-273/440.0
TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDksQNDK
.|..||||| .|| ||| .|  |. |||.|||.   |||
afiatqmpldstvldfwrlvhdyristiimlnq..lndk
fn3 Fibronectin type III domain 430-511 1.6e-08 27.8 Pfam-A 19-81 (85) alignment 
Range on Protein: 430-511
Range on HMM: 19-81/85.0
QWDPSSdTGEGPIVGYRIYVRSGNIVVlaekvqppsmventdrsVSKRSAENANEMvMYNVNGLEAGTTYSVQIAAIRDGIN
.|.|.. .|.|||.||.. .|. .                    ..|.    ....  ....||..||.|.....|. .. .
sWsppk.dgggpitgYeveyrekggge.................ewkeftvprttt.svtltgLkpgteYefrVqavngage
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 918-989 2e-08 28.7 In-house 8-86 (239) alignment 
Range on Protein: 918-989
Range on HMM: 8-86/239.0
NHPKNRYGNNIPLERNRVILD----SPEHDYINASYIK---GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDK
|. |||| | .  ...||.|.     |  |||||||..   |   ....||  . ..  ||| |. . .   ||||   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 918-989 2e-08 28.7 In-house 7-85 (239) alignment 
Range on Protein: 918-989
Range on HMM: 7-85/239.0
NHPKNRYGNNIPLERNRVILD----SPEHDYINASYIK---GVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDK
|. |||| | .  ...||.|.     |  |||||||..   |   ....||  . ..  ||| |. . .   ||||   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 917-993 3.1e-08 27.6 In-house 46-121 (303) alignment 
Range on Protein: 917-993
Range on HMM: 46-121/303.0
DNHPKNRYGNNIPLERNRVILDspEHDYINASYIKG-VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQND
.|  |||. . | |.  .| |   .  || |||..   .   . ||.||. | .||| |... |   ...|   |. |
knmdknrfvdvicldhskvkls..dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseyd
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 619-714 4.3e-08 27.0 In-house 23-117 (332) alignment 
Range on Protein: 619-714
Range on HMM: 23-117/332.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDipHSDYFNASYIPSFDNEKAYIASQGPNAA-SMDDFWRMVWQENVTTIAMVTKLQEGDKIK
 ||.|  .   |.  ||   .  .| .||.|   |   . |..|||..  . .. ||| .| |    .   ||||| . . . | ..  ..| .| |
typntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 949-994 4.3e-08 27.3 In-house 82-129 (301) alignment 
Range on Protein: 949-994
Range on HMM: 82-129/301.0
YI--KGVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDK
.|  .|    |..|| ||. |  ||| |.  |.  .||||  | .. .
wiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 918-989 4.4e-08 27.1 In-house 55-130 (305) alignment 
Range on Protein: 918-989
Range on HMM: 55-130/305.0
NHPKNRYGNNIPLERNRVILDSPE-HDYINASYIKGV---HCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDK
.  |||| .    ... | || |   ||| | |.      .  |. .| ||  |. .|| ||.. |   ||||   
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlckt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 669-861 4.6e-08 26.1 In-house 111-307 (346) alignment 
Range on Protein: 669-861
Range on HMM: 111-307/346.0
FDNEKAYIASQGP---NAASMDDFWRMVWQENVTTIAMvtkLQEGDKIKCR--QYWPNKQGDSVKFGnfKVELESLEACTGGVKRKMTM---RKGDDCRT
|. |.  | .| |   | . ..||| |..||..  . .   .   ||.|      . ...|     |  |. ..   |   |  .. |.    .|.    
fqfehklivaqlpqmenesfvedfwymiyqeqihlvyl...mvpddklkntttslfndenggyqytg..kmfinnrradvsgdpkeytievlpegnsdsv

VTQF-HFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAFIYGAV
. |  | . |     | .|  ..|.|.. ....   .  . .    | ||.   |     .         .... . ||...||  |..  ||| ||  |
icqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaiv

LE
..
fd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 940-990 6e-08 26.6 In-house 68-120 (347) alignment 
Range on Protein: 940-990
Range on HMM: 68-120/347.0
PEHDYINASYIKG--VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKS
. . |||||.||    .  .. || ||| || ||| ||   | . .| . .  
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 998-1099 6.4e-08 27.0 In-house 95-198 (198) alignment 
Range on Protein: 998-1099
Range on HMM: 95-198/198.0
TVTQYQFHGWPKHGSDQQSGARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEG--NSVDIFQTVKMLRADRMQSVQTGEEYAF
 ...|||  | .. . . .    ..   | |    . .|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

IYDV
||.|
iyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 998-1099 6.5e-08 27.0 In-house 96-199 (199) alignment 
Range on Protein: 998-1099
Range on HMM: 96-199/199.0
TVTQYQFHGWPKHGSDQQSGARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEG--NSVDIFQTVKMLRADRMQSVQTGEEYAF
 ...|||  | .. . . .    ..   | |    . .|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

IYDV
||.|
iyqv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 942-992 1.4e-07 25.1 In-house 90-144 (349) alignment 
Range on Protein: 942-992
Range on HMM: 90-144/349.0
HDYINASYIKG----VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQN
.||||| |.|     |.  ...||.|||.|| ||. ..|  .   .. |||  ..
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel
0038934 (Phosphotyrosine protein) phosphatases II 763-854 3.5e-07 25.6 In-house 81-168 (194) alignment 
Range on Protein: 763-854
Range on HMM: 81-168/194.0
QFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQY-THPLIIHCSAGVGRTGVVIsidsvVAHAKKTRMVDVFNFVTNIRRKRPYMVQTKEQYAF
...   .||.|..  .. ||.|.. |.  . .   .   .|| ||.||||...     .|.  ...  ..   .  .|.||| .... ...  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdylea
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1002-1105 6.1e-07 23.3 In-house 176-280 (303) alignment 
Range on Protein: 1002-1105
Range on HMM: 176-280/303.0
YQFHGWPkHGSDQQSGARSLLKLIRAVKGSTNSKKEF-SILVHCLSGAGRTGVFCT-ATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFIYDV
.... || |.|    |.  ..| |  ..       .    .   ||| ||.| |.   |  ..  .| .|.|. . ....|  |...||   .....| .
hhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl

IREYLH
. |.. 
laehvl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 997-1106 6.5e-07 22.3 In-house 204-311 (346) alignment 
Range on Protein: 997-1106
Range on HMM: 204-311/346.0
HTVTQYQFHGWPKHgSDQQSGARSLLKLIRAVKgSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQVAEGNSVDIFQTVKMLRADRMQSVQTGEEYAFI
  . | . |   ||  .|   .  ..|.|   . | .  ..  . |  | |.||.  |  |   | |. .|   .|.. .| .. .|  .|..  .|| |
svicqvhhhapwkh.lqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasi

YDVIREYLHT
| .. .|.  
yaivfdyiar
0038934 (Phosphotyrosine protein) phosphatases II 953-1056 1.1e-06 23.9 In-house 16-134 (194) alignment 
Range on Protein: 953-1056
Range on HMM: 16-134/194.0
VHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDkASHTVT------Q----------YQFHGWPKHGSDQQSGARSLLKLIRAVKGSTNSKK
.   |  . .||. .. .... .... |...| . .  . .   . ..                 .... .|  .         ||. ...|.  .| ..
itgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvk.lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

EFSILVHCLSGAGRTGVFCT
.  ..|||  | ||||... 
ggvvaVHCkaGlgRtGtlva
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 872-953 1.4e-06 22.4 In-house 7-84 (95) alignment 
Range on Protein: 872-953
Range on HMM: 7-84/95.0
VIHFTDHLQDLHTSVDgngrSKMSKEFQSLCPDPPASQTrSGLAPDNHPKNRYGNNIPLERNRVILDS-PEHDYINASYIKGV
|  |  |. ..|.  |     .. .||.|.     |. |  | .  | ||||. | .| .  ||.| .  . ||||| .. | 
vsvfhshvlemhsnsd....qefdnefksismtsgapyt.vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 620-778 1.5e-06 21.2 In-house 17-158 (169) alignment 
Range on Protein: 620-778
Range on HMM: 17-158/169.0
YPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNAsyipsfdnekayiasqgpnaasmddfwRMVWQENVTTIAMVtklqeGDKIKCRQYW
| . .|.  .|  |||    |    .||||. . .   ||| ||                           ||.|. | . | ..     ||     ..|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfw

PNKQG----DSVKFGNF-----KVELESLEACTGGVK----RKMTMRKGDDCRT--VTQFHFTEWPDKGVPKHT
|.|.      .| .|..      |  . ..| | ||.      | . . ||  |  .. .|.. ||..|||.  
pekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqsp
subfamily_PTPDC1_pd Subfamily PTPDC1 1017-1098 1.6e-06 22.6 In-house 94-170 (182) alignment 
Range on Protein: 1017-1098
Range on HMM: 94-170/182.0
GARSLLKLIRAVKGSTNSKKEFSILVHCLSGAGRTGVFCTATECIAQvaegnSVDIFQTVKMLRADRMQSVQTGEEYAFIYD
|..|| ...  ||  . . .|  . ||| .| |||||  ..    |.     ...  ...|..|. | .|.|| |   .. .
gvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvke
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 881-955 1.7e-06 21.6 In-house 10-88 (440) alignment 
Range on Protein: 881-955
Range on HMM: 10-88/440.0
DLHTSVDGNGRSKMSKEFQSLCPDPPASQTRSGLAPDNHPKNRYGNNIPLERNRVILD----SPEHDYINASYIKGVHC
|.   |. | ||.  ..  || |   .. .     |.|. |||| | .  ...||.|.     |. ||||||||.|...
dfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
Neocarzinostat Neocarzinostatin family 304-371 2.5e-06 13.9 Pfam-A 2-70 (110) alignment 
Range on Protein: 304-371
Range on HMM: 2-70/110.0
VSVSKRSAENANEMVMYTVNGLEAGTTYSV-QIAAIRDGINGCCRDPFTELWKTSNSSVTSGATLNNSF
||||  |     . |  .. ||.|||.|.| | | . || ..|    ||..   .. ...   .  .||
vsvsPasGLsdGqtvtvsasGlaagtaytvgqCavvedGvlaCnaaeftdvtadaaGeastslvvrrsf
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 620-778 2.5e-06 20.4 In-house 16-157 (169) alignment 
Range on Protein: 620-778
Range on HMM: 16-157/169.0
YPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNAsyipsfdnekayiasqgpnaasmddfwRMVWQENVTTIAMVtklqeGDKIKCRQYW
| . .|.  .|  |||    |    .||||. . .   ||| ||                           ||.|. | . | ..     ||     ..|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfw

PNKQG----DSVKFGNFK-----VELESLEACTGGVKR--KMTMRKGDDCRTVTQ----FHFTEWPDKGVPKHT
|.|.      .| .|..      |  . ..  | ||.   .... ...  ..||.    .|.. ||..|||.  
pekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqsp
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1036-1104 2.8e-06 20.9 In-house 264-344 (349) alignment 
Range on Protein: 1036-1104
Range on HMM: 264-344/349.0
KEFSILVHCLSGAGRTGVFCTATECIA--QVAEGNSV----------DIFQTVKMLRADRMQSVQTGEEYAFIYDVIREYL
.  ..|||| .| |||||..|    ..  .  . .|.           |. .|  ||  |.. ||   .. .||. . .|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 921-989 4.2e-06 20.7 In-house 46-116 (312) alignment 
Range on Protein: 921-989
Range on HMM: 46-116/312.0
KNRYGNNIPLERNRVILDSPEHDYINASYIKGVH--CTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDK
 ||| |    .| |  |   |  || | ..| .     |..|| ||  |.. || ..|    ..|..|   
lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 640-722 4.7e-06 20.9 In-house 3-72 (130) alignment 
Range on Protein: 640-722
Range on HMM: 3-72/130.0
LPYDSARVKleviddipHSDYFNASYIPSFDNEKAYIASQGPNAASMDDFWRMVWQENVTTIAMVTKLQEGDkikcrQYWPNK
|... .|..          .| |||..   .. . |. .| | |..  |||.|. .  |  . ..  ..| |     .|||. 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 956-998 5.6e-06 20.6 In-house 6-48 (199) alignment 
Range on Protein: 956-998
Range on HMM: 6-48/199.0
TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKASHT
 ...|| ||  |..||| || .     |||.||  .| .| . 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadyp
subfamily_PRL_pd Subfamily PRL 950-1087 7.1e-06 20.2 In-house 5-134 (151) alignment 
Range on Protein: 950-1087
Range on HMM: 5-134/151.0
IKGVHCTFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLNDKSQNDKaSHTVTQYQFHGWPKHgsDQQSGARS-LLKLIRAVKGSTNSKKEFSILVHCLSGA
|.  .  |. |. |  .|...| . . |.. .|.|   . . . . .   .  . . .. .  | .. ... . . .. .| . . . . .. |||..| 
ieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydte.klekegievldlafd..dGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRTGVFCtateCIAQVAEGnsVDIFQTVKMLRADRMQSV
||. |.     ..| . .|  ..  ..|...|  |  ..
GraPvlv....alalieaG..mkyedavefirekrrgai
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 997-1103 7.6e-06 19.8 In-house 167-268 (281) alignment 
Range on Protein: 997-1103
Range on HMM: 167-268/281.0
HTVTQYQFHGWPKHGSDQQSgaRSLLKLIRAVKGSTNskkefSILVHCLSGAGRTGVFCTATECIAQVAE-GNSVDIFQTVKMLRA-DRMQSVQTGEEYA
. .|.. .. ||     . |    .||..| ..  .        ..|| .| ||.| . .   ..  .       || | |  ||   |  |||| ..| 
rlithwlwkewpdwqvpess..evmlkilrkirarst.....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqym

FIYDVIREY
.|. |. ..
liwkvlldf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 917-988 9.4e-06 19.9 In-house 42-115 (288) alignment 
Range on Protein: 917-988
Range on HMM: 42-115/288.0
DNHPKNRYGNNIPLERNRVILDSPEHDYINASYIKGVHC--TFMTTQMPLPTTVSDFWSMVLKYKPSTIVMLND
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anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce