Gene SpurPTP-sf1-8 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP085_AA protein Get Run
SpurP085_AA_243-304 phosphatase_domain Get Run
SpurP085_AA_328-519 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 328-520 1.2e-96 318.3 In-house 29-225 (297) alignment 
Range on Protein: 328-520
Range on HMM: 29-225/297.0
NSKRRCTLLS-IQTATKTENR---SKSRYTNSLPMDRNRVILQSRGSS-DSDFVNASFVKGIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK
. ...|.. . ||..|..|..   .||||.|.||.|..||.|...... |||.||||||||..||.|||||||..|||||||||.|...|.|||||||..
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddne

SNESCARYWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRAPYLLNLMTEVEDSFSGVAEGfPVLVHCL
....||||||||||||||.|||..||||||.|||.||.|||....|||.|||||||..||.||.||.|.|..||.|..||...||..||| |.|||||
rdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.Pllvhcl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 244-470 1.5e-64 213.0 In-house 217-455 (515) alignment 
Range on Protein: 244-470
Range on HMM: 217-455/515.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEVPRN------SKRRCTLLS
 ||||||||..|||||||.|| |. ||.| .| ..||.|||.|||.|||.|.| |||| |.  .| |   ||   | .|.            |   || |
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks

I-------Q--TATKTENRSKSRYTNSLPMDRNRVILQSrgsSDSDFVNASFVKGIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNESCA
.       |  ..   .|. |.|| |.||..||||||.|    | |..||| .|||.  |.|||||.| ||.|||.||.. .|| ||||||  ....|||
lcpdppasqtrsgrtrdnhpknrygnnlplqrnrvilds...pdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstivmlndksqndksca

RYWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKAR
.|| |     ||| ||.|||.|    .  |...||.|. . |
qywpdansvqfgsysvstlstssdgdmtirqlqvtrnskrnr
0050432 (Phosphotyrosine protein) phosphatases II 331-519 6.4e-49 162.3 In-house 53-239 (308) alignment 
Range on Protein: 331-519
Range on HMM: 53-239/308.0
RRCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILqsrgSSDSDFVNASFVKGI----RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-E
. ..||.. .| . ||..| ||.. || |..||.|    ...||..|||.|.|     ...|| || |.||||.||| || ... ..||||.. .  . |
svkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengre

SCARYWSDK---GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFsgvaEGFPVLVHC
 ||.|| ..   |....| ..||.||. .. ... |..|.| .. .  ..|...... ||       . .  ||... .|..|.    .| |..|||
kcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl....pggpivVHC
0051299 (Phosphotyrosine protein) phosphatases II 334-519 2.5e-47 157.1 In-house 37-226 (288) alignment 
Range on Protein: 334-519
Range on HMM: 37-226/288.0
TLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGS-SDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-ESCAR
. |.. .| . ||..| ||.. || |..||.|.. .. ..||..|||...|  . ..|| || |.||||.||| || ... ..||||.. .  . | ||.
pdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQN----NPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSgvAEGFPVLVHC
||...|..|.| ..||.||. .  ... |..||| .     ..  . |...... ||       | .  ||... .| ....  . | ||.|||
Ywplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkala..sgggpvvVHC
0046845 (Phosphotyrosine protein) phosphatases II 336-519 4.2e-47 156.3 In-house 18-211 (284) alignment 
Range on Protein: 336-519
Range on HMM: 18-211/284.0
LSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGS--SDSDFVNASFVKGI-------RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-E
||. .| . ||.|| ||.. || |..||.|.| ..  .|||..|||.|.|        ...|| ||.|.||||.||| || ... ..||||.. .  . |
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

SCARYWSDKG-VTTFGSVSVTTLSVSERRGFIEREIEVTQNN-PKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
 ||.||...| | |.| ..||.||. .. ... |..|.| .. ..  . |...... ||       . .  ||... .|..... .  | |..|||
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHC
DSPc_SM00195 332-519 8.6e-47 155.0 In-house 16-202 (263) alignment 
Range on Protein: 332-519
Range on HMM: 16-202/263.0
RctllSIQTATKTENRSKSRYTNSLPMDRNRVILQSRG-SSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNESC
.    ....| | .|.|| ||.| ||.|..||.|...  ...||..||...||   ....| ||.|.|.||.||| ||.. . .|||||.....  .| |
k....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

ARYWSDK--GVTTFGSVSVTTLSVSERR-GFIEREIEVTQNNPKARHVVKQYQFIYWPTKaeERRDRAPYLLNLMTEVEDSFSGVaeGFPVLVHC
.||| ..  | .|||..||.. .| ...  .| |..|.|.....  . |.|||.  || .  .  | . ..|.|. .|. | |      |..|||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts..sgpivVhC
PTPc_SM00194 332-519 8.6e-47 155.0 In-house 16-202 (263) alignment 
Range on Protein: 332-519
Range on HMM: 16-202/263.0
RctllSIQTATKTENRSKSRYTNSLPMDRNRVILQSRG-SSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNESC
.    ....| | .|.|| ||.| ||.|..||.|...  ...||..||...||   ....| ||.|.|.||.||| ||.. . .|||||.....  .| |
k....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

ARYWSDK--GVTTFGSVSVTTLSVSERR-GFIEREIEVTQNNPKARHVVKQYQFIYWPTKaeERRDRAPYLLNLMTEVEDSFSGVaeGFPVLVHC
.||| ..  | .|||..||.. .| ...  .| |..|.|.....  . |.|||.  || .  .  | . ..|.|. .|. | |      |..|||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts..sgpivVhC
0036941 (Phosphotyrosine protein) phosphatases II 329-519 3.2e-46 153.4 In-house 22-214 (297) alignment 
Range on Protein: 329-519
Range on HMM: 22-214/297.0
SKRRCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILqsrGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNE
  ..  | |. .| . ||..| ||.. || |..||.|   ....||..|||.|.| .  ..|| || |.||||.||| || ... ..||||....    |
llpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

SCARYWSDK--GVTTFGSVSVTTLSVSE--RRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
 ||.||...  .. |.| ..||.|||..    ... |..||| .. .  ..|...... ||       . . .||... .|..  .   .| ||||||
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp..dhgvpespaslldfielvrkvlkllpsggpvlVHC
0040438 (Phosphotyrosine protein) phosphatases II 334-519 4.8e-46 152.9 In-house 31-216 (317) alignment 
Range on Protein: 334-519
Range on HMM: 31-216/317.0
TLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGS-SDSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKS-NESCAR
.| ....| . ||..| ||.. || |..||.|.. |.  |||..|||.|.|   ...|| || |.||||.||| || ... ..||||.. .   .| ||.
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaq

YWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSgvAEGFPVLVHC
||......|.| ..||.||. |  |.. |..||. .. .  . |...... ||       .    ||... .|.....   .| ||||||
YwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp..dhgvppspdllldfleavreale..dpggpvlVHC
0047943 (Phosphotyrosine protein) phosphatases II 334-519 7.6e-46 152.1 In-house 26-212 (273) alignment 
Range on Protein: 334-519
Range on HMM: 26-212/273.0
TLLSIQTATKTENRSKSRYTNSLPMDRNRVILqsrGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKS-NESCARY
.||....| . ||..| ||.. || |..||.|   |...||..|||.|.|  . ..|| ||.|.||||.||| || ... ..||||....   .| ||.|
plltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqY

WSDKG---VTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
|...|   ..|.| ..||.||. .. ... |..|.| .. .  ..|.....  ||       .   .||... .|.. .. . .. ||.|||
wpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHC
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 339-520 1.6e-45 150.3 In-house 37-218 (315) alignment 
Range on Protein: 339-520
Range on HMM: 37-218/315.0
QTATKTENRSKSRYTNSLPMDRNRVIL-QSRGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNE-SCARYWSD-
..| .|.| .| || | ||.|..||.|     | |||..|||..|.. .   .|..|.| . .| ||| ||...... |||... ....  .|..|| | 
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-KGVTTFGSVSVTTLSVSERRGFIEREIeVTQNNpKARHVVKQYQFIYWPTKAEERRDRapYLLNLMTEVEDSfsGVAEGFPVLVHCL
    . |||..|..||..   . . |.. ||..  .. . | |.||  || |  ...     ||.|. ||  .     . |..||||.
kadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqts..sllklikevkad..ngkkefsllvhcs
0039614 (Phosphotyrosine protein) phosphatases II 337-519 3.3e-45 150.2 In-house 47-229 (297) alignment 
Range on Protein: 337-519
Range on HMM: 47-229/297.0
SIQTATKTENRSKSRYTNSLPMDRNRVILQSRGS--SDSDFVNASFVKGIRH---RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNESCARYW
.. .| . ||..| ||.. || |..||.|.. ..   |||..|||.|.| ..   .|| || |.|.||.||| || ... ..||||.. .  .  ||.||
dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqyw

SDKGVtTFGSVSVTTLSVSERRGFIEREIEVTQnnPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
...|  |.| ..||.|.| .. |.. |..|||    .  . |...|.. ||       . . .||... .|.. ..   .| ||||||
peegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp..dhgvppslellleflelvrealaelpkggpvlVHC
subfamily_PTPRD_pd Subfamily PTPRD 338-519 8.5e-45 148.4 In-house 40-221 (564) alignment 
Range on Protein: 338-519
Range on HMM: 40-221/564.0
IQTATKTENRSKSRYTNSLPMDRNRVILQ-SRGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSD
...|.| .|..| || | .. |..||.|.  .| ..||..||||..| |.   .| || |...|..||| || ... |.||||.   .|... |..|| .
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

KGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEErrDRAPYLLNLMTEVEDSFsGvAEGFPVLVHC
|| .|.|.. ||  .  |   .. |........ .  . |.|..|. || .     . |  ||.|...|...     .  |..|||
kgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvp..esatslLdlirkvraln.e.pdagPivVhC
0045450 (Phosphotyrosine protein) phosphatases II 335-519 1.7e-43 144.9 In-house 44-241 (307) alignment 
Range on Protein: 335-519
Range on HMM: 44-241/307.0
LLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGS--SDSDFVNASFVKG----------IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK
| .. .| . ||..| ||.. || |..||.|.| ..  .|||..|||.|.           . ..|| || |.|.||.||| |. ... ..||||.... 
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

-SNESCARYWSDKGVT-TFGSVSVTTLSVSERRGFIEREIEVTQN-NPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
  .| ||.||.|.| . |.| . ||.||...  |.. | .||| .   .  . |...... ||       .    ||... ||.. ..   .| ||||||
lgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp..dhgvppsfeelldfieevrkaleelpkggpvlVHC
0043336 (Phosphotyrosine protein) phosphatases II 331-519 5.1e-43 142.9 In-house 30-217 (278) alignment 
Range on Protein: 331-519
Range on HMM: 30-217/278.0
RRCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRG-SSDSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNES
....| .. .| . ||..| ||.. || |..||.|.. |   |||..|||.|.|    ..|| || |.|.||.||| || ... ..||||....  ... 
lsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvk

CARYWSdKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSgvAEGFPVLVHC
||.||. .|..|.| ..||.|.. .  ... | .||| .  .  . | .|... ||    .  .    ||... .| . ..   .. ||||||
caqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale..dsngpvlVHC
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 337-519 6.7e-43 142.0 In-house 47-230 (298) alignment 
Range on Protein: 337-519
Range on HMM: 47-230/298.0
SIQTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNE-SCARYWS
. . | |.||..| ||.. ...|  ||.|..  .  .||..||||... ..   ||.|| |...||.||| ||.... . ||||..   ...  . .|| 
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEVEDsFSGVAEGFPVLVHC
|.| .|.|...|. ||  |   .| |...|.... . .. |.| .|. || |.. .  ..  .|.|...|.      |   ||.|.|
degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenats..vldllrkvra.sqqqagnkpvivqC
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 341-520 1.6e-42 140.3 In-house 37-217 (515) alignment 
Range on Protein: 341-520
Range on HMM: 37-217/515.0
AT-KTENRSKSRYTNSLPMDRNRVIL-QSRGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNES-CARYWSDK-
 . .  | .| || | ||.|..||.|     . .||..|||.....     .|..|.| . .| ||| .|...... |.|...  ... . |..|| || 
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

-GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPkaRHVVKQYQFIYWPTKAEERRdrAPYLLNLMTEVEDSFSGVAegFPVLVHCL
     |||..| ..|..   | | |...|....    . | |..|  || |  ...  .  || |. ||  . . ..  .|...||.
gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt..hpliihcs
subfamily_Ptp69D_pd Subfamily Ptp69D 310-519 8.6e-42 138.3 In-house 13-226 (307) alignment 
Range on Protein: 310-519
Range on HMM: 13-226/307.0
IQASHFDSTLMNLQEVPRNSKRrCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMV
..... |.    ..|  .  .|  . .| ... | ||  | || .  . |..||.|.   |. |||..||||.||   ...||. | |. .|. ||| |.
lksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

IDYHPSIIVMLNDDDKSNE-SCARYWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNN-----PKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMT
 . .  .|||| . .  |.  ||.||..   . .|.. |.. | ..   .|.||..|....      .... | ||..  |.    .  . |  ||.|..
aeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklie

EVEDSFSGVaeGFPVLVHC
.|..  .      |..|||
qvrelykln..rsPivvhC
Y_phosphatase Protein-tyrosine phosphatase 346-519 1.3e-41 137.9 Pfam-A 1-177 (235) alignment 
Range on Protein: 346-519
Range on HMM: 1-177/235.0
NRSKSRYTNSLPMDRNRVILQSRGS-SDsdFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKS-NESCARYWS--DKGVTTF
|..| ||.. ||.|..|| |..... ||  ..||..|||    ..|| ||.|...|..|||.||.... ..||||...... .| ||.||.  ... .|.
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GSVSVTTL-SVS-ERRGFIEREIEVTQNNPKA-RHVVKQYQFIYWPTKAEErrDRAPYLLNLMTEVEDSFsgVAEGFPVLVHC
|...|..  ... .  ... |..|..... .  .. |||...  || .     . .  ||.|...|| |    |.  ||.|||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk..eaksgpvvVhC
Y_phosphatase Protein-tyrosine phosphatase 346-519 1.3e-41 137.9 In-house 1-177 (235) alignment 
Range on Protein: 346-519
Range on HMM: 1-177/235.0
NRSKSRYTNSLPMDRNRVILQSRGS-SDsdFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKS-NESCARYWS--DKGVTTF
|..| ||.. ||.|..|| |..... ||  ..||..|||    ..|| ||.|...|..|||.||.... ..||||...... .| ||.||.  ... .|.
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GSVSVTTL-SVS-ERRGFIEREIEVTQNNPKA-RHVVKQYQFIYWPTKAEErrDRAPYLLNLMTEVEDSFsgVAEGFPVLVHC
|...|..  ... .  ... |..|..... .  .. |||...  || .     . .  ||.|...|| |    |.  ||.|||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk..eaksgpvvVhC
0045098 (Phosphotyrosine protein) phosphatases II 338-519 5.6e-41 136.1 In-house 25-213 (278) alignment 
Range on Protein: 338-519
Range on HMM: 25-213/278.0
IQTATKTENRSKSRYTNSLPMDRNRVIlqsrgssdsDFVNASFVKGIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSDKGV
| .| . .|..| ||.. || |..||.         |..|||...| ...|| || |.|.|||||| |. ... ..||||..  ....| ||.|| ..|.
itpalylgnldknRykdilpydhsrVk.........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

TTFGSVSVTTLSVSERRGFIEREIEVTQN----NPKARHVVKQYQFIYWPTKAEERRDRAPYLLNLMTEVEDSFS-----------GVAEGFPVLVHC
 |.| ..||.||...   .. | ..||      .    . |...... ||       .   ..|.|. ....  .              .| ||||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC
0040439 (Phosphotyrosine protein) phosphatases II 339-519 1.1e-40 135.2 In-house 4-186 (249) alignment 
Range on Protein: 339-519
Range on HMM: 4-186/249.0
QTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKS-NESCARYWSDK
 .| . ||..| ||.. || |..||.|.. .|  .||..|||...|  | .||| || |.|.||.||| |. ... ..||||....   .| ||.||...
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
|....| ..||.||| .  ... |..|.| .  .  . |...|.. ||       .  . ||... .|.. ..   .| ||||||
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHC
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 341-519 5.3e-40 132.2 In-house 4-182 (250) alignment 
Range on Protein: 341-519
Range on HMM: 4-182/250.0
ATKTENRSKSRYTNSLPMDRNRVILQSR-GSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNESCARYWSDKGVT
| | .|. | ||.. ...|  ||.|..  |  .||..||||..| .  . ||.|| |...|. ||| ||.... . ||||..   |.. . .||  .. .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

TFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEVEDSFSgVAEGFPVLVHC
..|.| |. ||  |   .. |.. ..... . . .|.|..|. || |.  .  .|   |.|...|. |    |.  ||.|.|
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevata..vLellkkvqasqq.qagnaPvivqC
0042113 (Phosphotyrosine protein) phosphatases II 340-519 2.9e-39 130.4 In-house 3-183 (245) alignment 
Range on Protein: 340-519
Range on HMM: 3-183/245.0
TATKTENRSKSRYTNSLPMDRNRVILQSRGSS-DSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNESCARYWSDKG
.| . ||..| ||.. || |..||.|.. |.. |||..|||.|.|    ..|| || |.|.||.||| |. ... ..||||....  . . ||.||....
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

VTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSGvAEGFPVLVHC
..|.| ..||.||.    ... |..||| .  .  . | .|... ||       |   .||... .|..  .   .. ||||||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp..dhgvpdllellldflefvrkalae.dsngpvlVHC
subfamily_PTPN6_pd Subfamily PTPN6 334-519 8.1e-39 128.4 In-house 42-234 (306) alignment 
Range on Protein: 334-519
Range on HMM: 42-234/306.0
TLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGSSDSDFVNASFVK----GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCA
.||| . ..|.||..| || |.||.| .||||.. . ..||..||...|    | ....|.||  ...||.||| || . .  .|||.    ....| ||
kllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCa

RYWSDKGV-TTFGSVSVTTLSVSERRGFIEREIEVT-QNNPKARHVVKQYQFIYWPTKAEERrDrAPYLLNLMTEVEDSFSGVA--EGFPVLVHC
||| |.   ...|..|||..| .. . .| ||. |. ... |  . | ||.|  || ..  . |    .|.....|.   . ..  |  |..|||
rYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk.d.pgavLdfledvnrkqeeleeaeagpivvhC
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 338-519 8.4e-39 128.5 In-house 38-223 (305) alignment 
Range on Protein: 338-519
Range on HMM: 38-223/305.0
IQTATKTENRSKSRYTNSLPMDRNRVILQSRGSSD-SDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLN-DDDKSNESCARYWSD
|.  .|..|..|.|...  ..| .|.||. . | | ||..|||.|.| .  ...|..| |..||||||| .......| ||||    .  .. | .|| .
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe

KGVT--TFGSVSVTTLSVSERRGFIEREIEVTQ-NNPKARHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFSGvAEGFPVLVHC
.      ||..||.  | ..  ..|||...... .. |  ..| |||.  || .     . |  ||.|. .|. . .   .| |.||||
sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGv..pqfatsllslikrvqkdqkk.dkgvpllVhC
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 337-519 1.5e-38 127.6 In-house 38-220 (318) alignment 
Range on Protein: 337-519
Range on HMM: 38-220/318.0
SIQTaTKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWS
|... ..  |. | ||.| |. |. || ||   |. .||..||... | |.   .| .| |.|.|. ||| || . . ..|||| .  ... . ..||| 
slks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFSgVAEGFPVLVHC
.|| ...|.. |.  .  |   .. ||..||... ..  .|.||..  || .     . .  ||.|. .|.      ..  |..|||
skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv..pesgaslldlvrqvskaqq.ksgagpivvhC
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 244-316 1.6e-38 127.6 In-house 225-297 (297) alignment 
Range on Protein: 244-316
Range on HMM: 225-297/297.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFD
 ||||||||||.||||||||||.|||||||.|.|.||.|||.|||||||.||||||||||.|||||||||.|.
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 338-519 1.7e-37 124.3 In-house 40-228 (325) alignment 
Range on Protein: 338-519
Range on HMM: 40-228/325.0
IQTATKTENRSKSRYTNSLPMDRNRVILQSRGS-SDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNESCARYWSDK
 ..|.| ||..| |. | ...|..||.|....  ..||..|||...  .  . |...|.|...|. |.| .|.|.. |..|.||  |. ...|| || ..
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpke

--GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDR--APYlLNLMTEVEDSFSG-VAEGFPVLVHC
     |||.. |   .. |   .. | ..| | .      |||.|.  |.    ..|    ... |.|. .|..          |.||||
mgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi.lqlvkavservtantkastpilvhc
subfamily_PTPRB_pd Subfamily PTPRB 337-519 2.6e-37 123.4 In-house 42-225 (293) alignment 
Range on Protein: 337-519
Range on HMM: 42-225/293.0
SIQTATKTENRSKSRYTNSLPMDRNRVIL-QSRGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWS
....|....||.| |||| || | .|| | . ...|.||..||....| .  . ||.|| |.|.|| ||| || . . |||||| .  .|  . | .|| 
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

DK-GVTTFGSVSVTTLSVSERRGFIEREIEVTQnnPKARHVVKQYQFIYWPTKAEErrDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
..   ...|...|| .. .| . .. ||.....   |... |.||.|. ||       ...  ||... .|... .  |.  |..|||
adeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvP..ektktlldfvrtvreaiektaskrPivvhC
subfamily_PTPRK_pd Subfamily PTPRK 339-520 2.7e-37 123.3 In-house 36-218 (314) alignment 
Range on Protein: 339-520
Range on HMM: 36-218/314.0
QTATKTENRSKSRYTNSLPMDRNRVILQSR-GSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNESCARYWSDK
..| | |||.|.|... |..|| ||.|..  | ..||..||... . ..   || || |...||.||| .| |.. . ||||..  . ..  | .|| ..
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GVTtFGSVSVTTLSVSERRGFIEREIEVTQ--NNPKARHVVKQYQFIYWPTKaeERRDRAPYLLNLMTEVEDSFSGvAEGfPVLVHCL
. . .| . |. ....    .. |   |..   . .....|.|.||. ||.   .    |  ||.|. .|. |     .| ...|||.
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaG.rivvhCs
0037934 (Phosphotyrosine protein) phosphatases II 340-519 3.5e-37 123.6 In-house 4-185 (243) alignment 
Range on Protein: 340-519
Range on HMM: 4-185/243.0
TATKTENRSKSRYTNSLPMDRNRVILqsrgsSDSDFVNASFVKGIrHRFITTQMPMPNTVAD----FWAMVIDYHPSIIVMLNDDD-KSNESCARYWSDK
.| . ||.|| ||.. ||.|..||.|     ..||..||.....   |.| ||.|.|.||.|    || |. ... ..||||.... .. | ||.||...
iallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

GvtTFGSVSVTTLSVSERRGFIEREIEVTQNN-PKARHVVKQYQFIYWPtkAEERRDRAPYLLNLMTEVEDSFSG------VAEGFPVLVHC
   |.| ..||.||...  ... |.....  . ..  . | .|... ||       |    ||... || .  .         .| ||||||
v..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsggpvlVHC
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 337-519 4.8e-37 122.7 In-house 39-223 (319) alignment 
Range on Protein: 337-519
Range on HMM: 39-223/319.0
SIQTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIRHR--FITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDD-KSNESCARYWS
....|.| ||..| ||.| |..|| ||.|..  |. .||..||||. | ..|  || || |. ||. ||| || ... ||.|||...  | .  . .||.
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKA-RHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFSGVAEGfPVLVHC
.. ....| . || ..  |  ..| |.... ... .     ||..|.  || ..    ..|  ||.|. ... | ..  .| |. |||
eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv..Pekatslldllkrirksrektqsg.PivvhC
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 338-519 7.5e-37 121.9 In-house 39-219 (288) alignment 
Range on Protein: 338-519
Range on HMM: 39-219/288.0
IQTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSD
 ... ...| .| || | ||.| .|| |.     ...|..|||...| .  ...|.|| |...|| ||| .| ... | ||||..  .. .. | .|| |
vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd

KGV-TTFGSVSVTTLSVSERRGFIEREIEVTqnNPKARHVVKQYQFIYWPTKAeERRDRAPyLLNLMTEVEDSFSgvAEGFPVLVHC
..  . .||| || ... |   |..|....     | .  ..|||.  || .    .. || ||.|.. |. . .  |.  |..|||
adkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhg.vPeskap.llellrqvkvanq..adtgpiivhC
subfamily_PTPN12_pd Subfamily PTPN12 311-519 9.2e-36 118.2 In-house 6-214 (290) alignment 
Range on Protein: 311-519
Range on HMM: 6-214/290.0
QASHFDSTLMNLQEVPRNSKRRcTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGSSD-SDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVI
.  .| .  ..|... .. |.  .  | ....|.||. | || . || | .|| |.   ... ||..||.|.||    ...| .| |.|.|. ||| |..
geeefakefqklkklsekykae.kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

DYHPSIIVMLND-DDKSNESCARYWSDKGV--TTFGSVSVTTLSVSERR-GFIEREIEVTQNnpKARHVVKQYQFIYWPTKAeeRRDRAPYLLNLMTEVE
... .|.||.    .     |.|||...|   ..||...||. .      .|. | ..|...  |....|.|...  || .   .  .|  ||.|...|.
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhg..vPssaksllelielvr

DSFSgvAEGFPVLVHC
.  .  .|  |..|||
elqe..sedaPlvvhC
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 313-519 9.6e-36 118.7 In-house 27-231 (319) alignment 
Range on Protein: 313-519
Range on HMM: 27-231/319.0
SHFDSTLMNLQ-EVPRNSKRRCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVID
|.||  | .|. |  | .|.   |   . |   .|. | |..| |. |.|.| |.   |   ||..|||||.| .   ..|..| |..||.|||| |. .
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

YHPSIIVMLNdddksNESCARYWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQ-NNPKARHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFS
|. | ||.|      .. |..||  |.| . .   |   || |   .. |.||...  . |    ..|. |  || .     | .  |. |.  |.   |
yncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGv..pdypsdlmrlvkkvrhlts

GVAEGFPVLVHC
   .  ...|||
kenhranivvhc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 337-519 6.6e-35 115.4 In-house 37-223 (290) alignment 
Range on Protein: 337-519
Range on HMM: 37-223/290.0
SIQTATKTENRSKSRYTNSLPMDRNRVILQSR-GSSD--SDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARY
...... ..|. . |..| .. | ||..|.   |  |   ...||...||   ....| || |..||..||| .. . . .||||| .  .. .. |  |
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNP-KARHVVKQYQFIYWPTKAeERRDRAPyLLNLMTEVEDSFSGVAeGFPVLVHC
|.|......| .|.. |. ..  ..|||..||...|  .|.. |.|||.  |. .  .  ...   | ...|...         ...|||
Wpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqt.illvieemyktqrkrg.ntsivvHC
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 329-519 7.6e-35 115.8 In-house 8-195 (284) alignment 
Range on Protein: 329-519
Range on HMM: 8-195/284.0
SKRRCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNdddksNE
.|.   .   . |   .|. | |... |. |.|.| |.   |   ||..||||..| .  ...|.|| |..||.|||| |. .|. | ||.|      ..
cklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kd

SCARYWSDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQ-NNPKARHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
 |..||  |.| . .   |   ||.|   .. |.||...  . |    ..|. |  || .     | .  |. |.  |.   |   .  ...|||
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgv..pdypsdlmrlvkkvrhltskenhranivvhc
subfamily_PTPRA_pd Subfamily PTPRA 338-519 1.3e-34 114.6 In-house 50-235 (330) alignment 
Range on Protein: 338-519
Range on HMM: 50-235/330.0
IQTATKTENRSKSRYTNSLPMDRNRVILQ-SRGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSD
...|.| ||. |.|. | || | .||||.  .|  .||..||||..| ..  .||..| |  .|| ||| |. ... . |||| . ... .| ||.|| |
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

KGVTTFGSVSVTTLSVSERRGFIEREIEVTQ----NNPKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEVEDSFSGVAEgfPVLVHC
.|. |.| . |.   . .   .  |.. |.|     . |.  .|.|. |  ||        .   .|.|. .|.      |.  |. |||
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG..mlkllkkvkklnqqsag..pivvhc
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 342-519 1.6e-34 114.2 In-house 43-218 (287) alignment 
Range on Protein: 342-519
Range on HMM: 43-218/287.0
TKTENRSKSRYTNSLPMDRNRVILQsrgSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSDKGVTT
  ..|. | |.|. |. | .||.|.     . |..||.|..| .  ..|| .. || ||. .|| .. | ....|||| .  .. .| | .||...  ..
iasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

FGSVSVTTLSVSERRGFIEREIEVTQNN-PKARHVVKQYQFIYWPTKAEERRdRAPYLLNLMTEVEDSFSGvAEGfPVLVHC
.|  ... |.     |.|||..||...|  .... |||||.  |. . .  .  .  || .   .       ... ...|||
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvte.pqtillvieemyktqrkr.gnt.sivvhC
subfamily_PTPN23_pd Subfamily PTPN23 315-520 2.7e-34 113.3 In-house 17-220 (288) alignment 
Range on Protein: 315-520
Range on HMM: 17-220/288.0
FDSTLMNLQEVPRNSkrrCTLLSIQTAtkTENRSKSRYTNSLPMDRNRVILQsrgSSDSDFVNASFVKGIRH---RFITTQMPMPNTVADFWAMVIDYHP
.| .  .|..   .        ||  |    . .| |... || |.||| |.   .|  |..||||||..      ||.|| |...|..||| || . . 
ldkkfkeleqkqdke...arkrsiaia..klyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

SIIVMLNDDDKSNE-SCARYWS-DKGV-TTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEErrDRAPYLLNLMTEVEDSFSG
|.|||| . .. .. ...|||  |||  ..|| .|||  || |   ..||..... ....| . |.  |.  ||       .    ||... |||.... 
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvP..asPetllqfldevesayea

VA--EGFPVLVHCL
|      |..|||.
vqrksktPlvvhCs
subfamily_PTPRG_pd Subfamily PTPRG 336-519 4.5e-33 109.3 In-house 37-227 (563) alignment 
Range on Protein: 336-519
Range on HMM: 37-227/563.0
LSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGSSDS--DFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARY
| .... |.||. | ||.| ...|| || |..    ..  |..||....| .  . ||.|| |...|. ||| |. . . .||||. .  .. .. | .|
ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvY

WSDKGVTTFGSVSVTTLS-----VSERRGFIEREIEVTQNNP-KARHVVKQYQFIYWPTKAEERrDRAPYLLNLMTEvedSFSGVAEGFPVLVHC
|   .. |.|...||  .     ..  | .. ..... ...  .  ..|.||.. .|| ..      .| | .   .   | .  ||  |..|||
WPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe.hslpvLifvkks...saankaeaGPivvHc
subfamily_PTPN3_pd Subfamily PTPN3 333-519 5.8e-33 109.0 In-house 28-215 (280) alignment 
Range on Protein: 333-519
Range on HMM: 28-215/280.0
CTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSrgsSDSDFVNASFVK------GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNE
   |.|..| |.|| || || . || |  ||.|..   |..|..||..|.      |.  |.|.|| |...|..||| || . . |.|||| .  ..   
kpglaisaarkpenlsknryrdilpydatrvklke...setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

SCARYWSDKG-VTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFSGVAEgfPVLVHC
 | .|| ...  ...|. ||.  . .|.. .. ||. ..... | .. . | |.. || ..    | .  .|.....|..  ||  |  ||.|||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgv..Pddsadflefvervrklrsgkee..PvvvhC
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 340-519 8.1e-33 108.7 In-house 34-215 (281) alignment 
Range on Protein: 340-519
Range on HMM: 34-215/281.0
TAT-KTENRSKSRYTNSLPMDRNRVIL-QSRGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDD-KSNESCARYWSDK
||. . ||. | ||.|    |  || . ..  ....|..||.||.|    ...|.|| |.|.....|| ||.... |.|||.  .  ...  | ||| |.
taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

G-VTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVvKQYQFIYWPTKAEERrdRAPYLLNLMTEVEDSfSGVAEGFPVLVHC
   ...| | |.... .|.. .|||........ ..|.| .| ... || .       .  ||.  .||.   .   .  |...||
nselkygdvtvkstaeeekatyierkfkleresgetrev.eqlaytaWPdhGvPa..ttkellefrkevlkl.tekktkaplvihC
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 334-519 6.9e-32 105.6 In-house 37-219 (315) alignment 
Range on Protein: 334-519
Range on HMM: 37-219/315.0
TLLSIQTATKTENRSKSRYTNSLPMDRNRVIL-QSRGSSDSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCAR
 |  ...| |.||. | || | ...|. || |      ..||.|||.|..|   ..|.|..| | ...| ||| .| ... . ||||..  .. .. . .
qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek

YWSDKgVTTFGSVSVTTLSVSERRGFIEREIEVTQNNpKARHVVkQYQFIYWPtKAeERRDRAPYLLNLMTEVEDSFSGVAegFPVLVHC
|| ||   ..| ..||  |      .  | . |. .. . |.|| |...  || .. .    .  |.||.  |       .   ...|||
ywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd.nirevv.qlhytswp.dm.gvpkytiplmnlirtvkqhhtnsv..gaivvhc
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 345-519 3.3e-31 103.4 In-house 27-208 (274) alignment 
Range on Protein: 345-519
Range on HMM: 27-208/274.0
ENRSKSRYTNSLPMDRNRVILQSRGSS--DSDFVNASFVKGIRH---RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNE-SCARYWSDKGVT-
 . .| ||.. || .. ||.|.|. |.  ||...|| ..|| ..    .. || |.|||||||| |.   . ..|||| .   .||  ||.|. |.  . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---TFGSVSVTTLSVSERRGFIEREIEVTQNNPkARHvVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEDSFSGVAEG-FPVLVHC
   ..| |.... .. || ..  |.. . . .   |. || | .  || .     |.|  ||.|..|||.| .  ..   ||.|||
iserygdveikvekiverndysvrklvlkyler.ers.vkhywytdWPdhks..PddantlldlvleveesreeenaklapvvvhC
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 336-519 4.7e-30 99.4 In-house 28-217 (287) alignment 
Range on Protein: 336-519
Range on HMM: 28-217/287.0
LSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVML-NDDDKSNESCARYWS
.  ..|... . .| ||.. ||.| .||.|   |   ||..|| .| . .  ..||..| |.. || ||| .|.. . . ....  . ...   | .|| 
atfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

DKGVT-TFGSVSVTTLSVSERR-GFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERR--DRAPYLLNLMTEVEDSFSGVAEGfPVLVHC
.. |    |  ||. |. . .   .  | . . . . .  .||||.... || |.        . . |.    .| . ..   | |..||.
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG.Plvvhd
subfamily_PTPN13_pd Subfamily PTPN13 336-519 9e-30 98.9 In-house 27-209 (273) alignment 
Range on Protein: 336-519
Range on HMM: 27-209/273.0
LSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGSsdsdFVNASFVKG----IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDD-KSNESCARY
.. ... | ||..| || | ||.|. ||.|.. |.    ..|||..|      ....| .| |.|.||.||| || . . ..|.|.  .  | .  | ||
dtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WSD---KGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERrdRAPYLLNLMTEVEDsFSGvaEGFPVLVHC
| .   | ..  . . |. | | .. ||  |...|.... .. . | . .|. ||     .   |  ||....||   .    .  |..|||
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPs..saaellqfvaevrr.lqt..dagPivvhc
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 341-519 8.5e-29 95.4 In-house 15-204 (270) alignment 
Range on Protein: 341-519
Range on HMM: 15-204/270.0
ATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIRH---RFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSDK-
 . . ..   ||.. ||  . ||.|.. .  | . ..|| .|.|. .   ..|... |.|.|. .|| |... . . |||. .  .| .. |.|||. . 
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

---GVTTFGSVSVTTLSVSERRGFIEREIEVTqNNPKARHVVkQYQFIYWPTKAEER----RDRAPYLLNLMTEVEDSFSGVAEGFPVLVHC
     ...| ..|..|| . ..|.| ...... .. . |..|  ...  || ..  |      ..  ||... .|  | .  ... |.||||
kekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc
subfamily_PTPN9_pd Subfamily PTPN9 339-485 1.2e-28 95.0 In-house 35-187 (297) alignment 
Range on Protein: 339-485
Range on HMM: 35-187/297.0
QTATKTENRSKSRYTNSLPMDRNRVILQSR-GSSDSDFVNASFVKGIRHR--FITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWS--
... .  | .| |||. | .|. || |... . . ||..||.|| | ...  ||.|| |...|| ||| || . .  .|||     ..    |..||   
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKA
.. .. ||..||....| |.. . .| .|... . .    |  .||. ||   
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyG
subfamily_PTPRD_pd Subfamily PTPRD 244-329 1.4e-28 94.8 In-house 222-307 (564) alignment 
Range on Protein: 244-329
Range on HMM: 222-307/564.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEVPRNS
.|||||||. . ||...  .|  | |||..||...|..|..||||.||| |.. |.|||| . .| ...... ..|..|.|| ...
SaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 244-325 1e-27 91.8 In-house 218-299 (315) alignment 
Range on Protein: 244-325
Range on HMM: 218-299/315.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEV
 ||||||||..|||.|||..|||. ||.| .| ..|..|||.|||.|.|.|.| |||| |.  .| |   ||   | .|.  
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhts
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 243-323 8.5e-27 88.5 In-house 176-256 (392) alignment 
Range on Protein: 243-323
Range on HMM: 176-256/392.0
GCAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQ
 .||||||||..||||||| ||.|. ||.| .|...|..|||||||||||.|.| |||| |.  .| |   ||   | .|.
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 338-519 1.2e-26 88.2 In-house 25-206 (283) alignment 
Range on Protein: 338-519
Range on HMM: 25-206/283.0
IQTATKTENRSKSRYTNSLPMDRNRVILQSRGSsdsDFVNASFVK-----GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYW
 . |.  ||. | |. . .|.|..|| |.|      |..||.|.         ...| .| |. .|| ||| || | . . ||||    .  .. |..||
adiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

SDKGVTTFGSVSVTTLSVSERRGFIEREIEVTQN-NPKARHVVKQYQFIYWptkaEERRDRAPylLNLM---TEVEdSFSGVAEGFPVLVHC
  .|   .|   ||       . || .|. . .|   |.  ..  ||.| |     |  . |.  .| .     |  |     .  |..|||
PkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqai..inslvkfnkvi.slqteskkgPivvhC
subfamily_CG7180_pd Subfamily CG7180 339-519 3.9e-26 86.4 In-house 35-230 (296) alignment 
Range on Protein: 339-519
Range on HMM: 35-230/296.0
QTATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNESCARYWSDKG
... ..||| | |. . .| | |||.|..  | ..||..||..| .    . .| |..|. .|| .|| .| | . | .|.| .    .. .  ||  |.
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks

VTTFGSVSVTTLSVSERRGFIEREIEVTQN----------NPKARHVVKQYQFIYWPTKAEERrDRAPYLLNLMTEVEDSFSGV---AEGFPVLVHC
 . .| . | .... .   .  |.. .|..                .||..|.  |. . .     .  |..|.  |.     |    |  ||.|..
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP.lstnalielrrrvrlwrekvdedpeegPvvvvs
subfamily_PTPN1_pd Subfamily PTPN1 327-519 6.9e-26 85.6 In-house 13-208 (290) alignment 
Range on Protein: 327-519
Range on HMM: 13-208/290.0
RNSKRRCTLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSrgsSDSDFVNASFVK--GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKS
.. .. .. .....| . |||.. || .  | |  |..|..   .| |..|||.|.   .....| || |.||||. || || . .   .||||   .|.
ldirkeasdfptreaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

NESCARYWSDK---GVTTFG--SVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERrdRAPYLLNLMTEVEDSFSGVAEGFPVLVH
.  ||.||  .      ..   ...|. .|  ... .. | .|... . .  ... .. .. ||  .  .     ..|... .| .| | . .  |...|
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpe..spaaflkflfkvresGslssdvGpavih

C
|
c
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 242-329 3.1e-25 83.9 In-house 219-306 (318) alignment 
Range on Protein: 242-329
Range on HMM: 219-306/318.0
GGCAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEVPRNS
   |||||||| . .|...  .|  . ||.|..|...|..|. ||||..||.|.| ..|||| | || ..||.. | . .|.|.  .|
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpes
subfamily_PTPN14_pd Subfamily PTPN14 330-519 2.9e-24 80.6 In-house 34-236 (300) alignment 
Range on Protein: 330-519
Range on HMM: 34-236/300.0
KRRCtLLSIQTATKTENRSKSRYTNSLPMDRNRVILQSRGSSDSDFVNASFVK----GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSN
|.|     ..||.  || .|.|. . || . ||| |..   ......||| .|    | .. .|..| |...|| ||| || . . ..|||| .. .. .
kkre.dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

ESCARYWSDK----GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEeRRDRAPYL--LNLMT----EVEDSFSGVAEGFP
| . .|. ..       .||   |||  ...   .| . ...     | .  |   |.. || .    .|  ..|  |. .     ..... ..  .  |
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgv.PeDvkgflsyLeevqsvrrktnseveskeskPP

VLVHC
|||||
vlvhC
0049772 (Phosphotyrosine protein) phosphatases II 337-519 8.6e-24 80.2 In-house 37-219 (314) alignment 
Range on Protein: 337-519
Range on HMM: 37-219/314.0
SIQTATKTENRSKSRYTNSLPMDrNRVILQSRGSSDSDFVNASFVKGIrHRFITTQMPMPNTVADF----------WAMVI--DYHPSIIVM--------
.| .| . .||.| ||.. ||.| |||||.. . |.||. |||.|.|.  .|| || |...|| ||          | ||.  |... .|||        
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LNDDDKSNescaRYWSDKGVTTFGsvsvttlsvserrgfiereiEVTQNNPKARHVVKQYQFIYWPTKAEErrdRAPYLLNLMTEVE
             |.. |  .     ... . . ..                     |.. ....  . . .|  | .|   .       ... ..  .|
elsrLdaAlgKtpllildgng....neptaadlellk....................eelydpelferlgikylripvpDgsap...lledfdeflefie

DSfsgvAEGFPVLVHC
.      .| ||||||
ea....dkggpvlvHC
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 345-519 1.1e-23 78.7 In-house 2-179 (237) alignment 
Range on Protein: 345-519
Range on HMM: 2-179/237.0
ENRSKSRYTNSLPMDRNRVILQSRGSSdSDFVNASFVKG---IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-ESCARYWSDKG-VTTF
||. |.|| |   .| .||.|.  ||. ||..||...||     ...|..| |. ..  ||| || . . |.||||    ..| . | .|| .    ...
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GSVSVTTLSVSERRGFIEREIEVTQ-NNPKARHVVKQYQFIYWPTKAEERRdrAPYLLNLMTEVEDSFSGVAEGFPVLVHC
| ..|.     |   .  | . ...  . |   ...||||  || .   ..  .  || .  .. .    |.|  | ..||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqq..taallrfrkniinrsphvsesgpwiihc
subfamily_PTPRN_pd Subfamily PTPRN 339-519 1.3e-23 78.2 In-house 49-231 (297) alignment 
Range on Protein: 339-519
Range on HMM: 49-231/297.0
QTATKTENRSKSRYTNSLPMDRNRVILQSRGS-SDSDFVNASFVKGIRHR---FITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSD
..| . .| .| |... || | .|| |... | ..||..|||..     |   .|.|| |...|||||| || .    .||.|    ... . |.||| |
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

KGVTTFGSVSVTTLSVSE-RRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEVEDSFSGvaEGFPVLVHC
.|  ...   |  .|       .. | . . . . .    | |. |. || ..     ..  ||..   |. |. |     |..|||
eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaks..llefrrkvnksyrG..rscpivvhc
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 339-519 1.3e-23 78.1 In-house 33-233 (301) alignment 
Range on Protein: 339-519
Range on HMM: 33-233/301.0
QTATKTENRSKSRYTNSLPMDRNRVILQSRGS---SDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWS
.  .. ||.  .|. |  ..| ||.||.   .   .  ...|||...|...  .|| .| || .|..||| ......|. |||. .  ......| .||.
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywp

DK--GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPK---------------ARHVVKQYQFIYWPTKAEERRDRAPylLNLMTEVEDSFSGVaEGFPV
.     ..|| ..||  .      |. |.. |. ..                 . . | |.| . ||.    |  |    |. . .|      . .| ||
nseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv..Lqviddvihrqqki.gggpv

LVHC
.|||
vVHC
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 339-441 5.2e-23 76.1 In-house 38-152 (392) alignment 
Range on Protein: 339-441
Range on HMM: 38-152/392.0
QTATKTENRSKSRYTNSLPMDRNRVIL-QSRGSSDSDFVNASFVKGIRH--RFITTQMPMPNTVADFWAMVIDYHPSIIVMLND---DDK--SNESCARY
..| |  |  | || | ||.|..||.|     ..|||..|||.....     .|..|.| . .. ||| || . ... |.|...    ||  .. ..|..
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqf

----WSDKGVTTFGS
    | ||.|  . |
hftewPdkdvpkhts
subfamily_ptpA1_pd Subfamily ptpA1 341-519 8.3e-23 75.8 In-house 42-236 (418) alignment 
Range on Protein: 341-519
Range on HMM: 42-236/418.0
ATKTENRSKSRYTNSLPMDRNRVILQS-RGSSDSDFVNASFVKGIR-HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSDK---
  |  | || |||| ||... || |.  .    ||..|| .. |   ..|| || |.|||.|||| || . .  |||||. . ..    | ||| ..   
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

--------GVTTFGSVSVTTLSVS--ERRGFIEREIEVTQNNpKARHvVKQYQFIYWPTKAE-ERRDRAPYLLNLMTEVEDSF-SGVAEGFPVLVHC
        |   ||. ||  . |     |  | |.| .| .  ..|  . |||.  || .   .. .    ||  .|. ..          |..|||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfeg.etrd.itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc
0041856 (Phosphotyrosine protein) phosphatases II 346-519 1.5e-22 75.5 In-house 1-116 (182) alignment 
Range on Protein: 346-519
Range on HMM: 1-116/182.0
NRSKSRYTNSLPMDRNRvilqsrgssDSDFVNASFVKGIRHR--FITTQMPMPNTVADFWAMVIDYHPSIIVMLNdddksnesCARYWSDKGvttfgsvs
|..| ||.. ||.|..|         |.|..||... | ..   || || |...|||||. |. ... ..||.|.        . .|| ..         
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell........

vttlsvserrgfiereievtqnnpkaRHVVKQYQFIYWPTKAEERrdrAPYLLNLMTEVEDsfsgvaEGFPVLVHC
                           . . ||... ||          . ||... ||..      || ||||||
..........................erlgiqylylpwpDhgvpd...ldelldfieevle......eggpvlVHC
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 346-490 1.8e-22 74.3 In-house 56-202 (290) alignment 
Range on Protein: 346-490
Range on HMM: 56-202/290.0
NRSKSRYTNSLPMDRNRVILQSrgSSDSDFVNASFVKGIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSDKG--VTTFGSV
.  | || .    |. ||||.     | |.| | .|||..  || || .. .|| |.| ||.. . . |||| .  .. .  |..|. .|   | |||..
efkknrykdvvcndktrvilkd..GydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei

SVT-TLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRD
.|. ... ..    | . . | . .    |..| .. . || |.    .
tvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 244-310 1.9e-21 71.6 In-house 231-297 (298) alignment 
Range on Protein: 244-310
Range on HMM: 231-297/298.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRI
 |||||.|    ||||.  .|. . ||.| .|  .|..|| .|||.|||.|.| |||||| | .. |
saGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 244-325 5e-21 70.2 In-house 229-310 (325) alignment 
Range on Protein: 244-325
Range on HMM: 229-310/325.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEV
 ||||||||..|. |..|.     .|||||.| |.|..|| ||.| .||...| |. ||..| .| .  | |.. | .||| 
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqer
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 244-318 1.8e-20 67.7 In-house 135-209 (440) alignment 
Range on Protein: 244-318
Range on HMM: 135-209/440.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDST
.||.|||||....||.. ||||. ..||| ... ||.||| |||| |||.||. ||||.|.. || |        
sagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdtliledditer
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 244-325 2.2e-20 68.0 In-house 224-305 (319) alignment 
Range on Protein: 244-325
Range on HMM: 224-305/319.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEV
 |||||||  . .| ..   |.   .|.| .||..|  |. |||..|||.|.| |.|||. . || |.  ..   |..|.| 
saGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek
subfamily_PTPRA_pd Subfamily PTPRA 244-323 3.5e-20 67.1 In-house 236-315 (330) alignment 
Range on Protein: 244-323
Range on HMM: 236-315/330.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQ
 ||||||| .. .|.|..  |  . ||.|. |...|..|| ||||.|||.|.| ..||  .  || ...| ... | .|.
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkly
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 244-305 1.7e-19 65.0 In-house 183-244 (250) alignment 
Range on Protein: 244-305
Range on HMM: 183-244/250.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFS
 |||||.|  . ||.|.  .|. | ||.| .. ..|..|| .|...||| ||| ..|.|| |
saGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 244-302 2.7e-19 64.3 In-house 181-239 (239) alignment 
Range on Protein: 244-302
Range on HMM: 181-239/239.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
 ||||||| .| ||... .||. | |||| ||  .|..||.|||| ||| |...|||||
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPRK_pd Subfamily PTPRK 244-326 3.6e-19 63.7 In-house 218-300 (314) alignment 
Range on Protein: 244-326
Range on HMM: 218-300/314.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQEVP
 || ||||. . ||.|.  ..| . ||.|  | ..|.... ||.|.|||.|.| ..||| .  .| | .|.| .. .. ... 
saGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirld
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 245-319 5.5e-19 63.4 In-house 225-299 (305) alignment 
Range on Protein: 245-319
Range on HMM: 225-299/305.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTL
|||||||| ...|  .  .|. ..||.|... ..|..|..||||..||.|.. |. | . . || |  | .   .
agvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 342-519 5.6e-19 62.9 In-house 44-219 (439) alignment 
Range on Protein: 342-519
Range on HMM: 44-219/439.0
TKTENRSKSRYTNSLPMDRNRVILQ-SRGSSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNEscarYWSDKGVTT
..  ...| || .  ..|  ||.||   |   | ..|| ..||    . .|.||.|  .|. ||| .||. . . |||| .  .|      ||  .. . 
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevc

FGSVSVTTLSVSERRGFIEREIEVTQNNP--KARHVVKQYQFIYWPTKAEerRDRAPYLLNLMTEVEdSFSGVAEGFPVLVHC
.| ..| .    |   .. | . | ..    .  . | |...| || |      .| ..|...  .. |     |  ||.|||
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknv..paqashvldflrain.sandkeeygpvvvhc
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 244-301 1.1e-18 62.3 In-house 182-239 (239) alignment 
Range on Protein: 244-301
Range on HMM: 182-239/239.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
 ||||||| .| ||... .||. | |||| ||  .|..||.|||| ||| |...||||
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0051429 (Phosphotyrosine protein) phosphatases II 373-519 1.5e-18 62.9 In-house 4-157 (272) alignment 
Range on Protein: 373-519
Range on HMM: 4-157/272.0
SDFVNASFVKGI-----RHRFITTQMPMPNTVADFWAMvIDYHPSIIVMLNDDDKSN-ESCARYWS------------DKGVTTFGSVSVTTLSVSERRG
|. .||..|.|      ..|.. ...|.|.|.||||..  ... . ||.| ...  . . | |||             .    ..| ..||.||..    
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FIEREIEVTQN-NPKARHVVKQYQFIYWPTKAEERRDrapyLLNLMTEVEDsfsgvaeGFPVLVHC
.| ||...|   .... . | ..... ||.    .      ||.|. .. |       | ||||||
yilrellltlllsagearevmhlhytdwpdhgvpqea....llellellld.......ggpvlvHC
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 345-438 5.4e-18 59.8 In-house 46-157 (350) alignment 
Range on Protein: 345-438
Range on HMM: 46-157/350.0
ENRSKSRYTNSLPMDRNRVILQ---------SRGSSDSDFVNASFVKGI--------RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-ES
|  .| ||.| || ...||.|.             | .|..||...|           ...| || |.|.|| ||. ...  .  .|..|..|.  | | 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CARYWSDKGVTT
| ||| . ..  
cyrYWqegsydd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 244-306 9.8e-18 59.2 In-house 220-281 (288) alignment 
Range on Protein: 244-306
Range on HMM: 220-281/288.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEaLFSE
 |||||||. ...| .. . .... .|..| |.|.|..|. .|||..|| |.| ..|. | .|
saGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls.liee
0050432 (Phosphotyrosine protein) phosphatases II 244-305 1.1e-17 59.7 In-house 240-301 (308) alignment 
Range on Protein: 244-305
Range on HMM: 240-301/308.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFS
 |||||||... .| ..   .....||.|..| |.|. ||.||||.||| |.| |.|| |..
saGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
DSPc_SM00195 245-302 1.2e-17 59.5 In-house 204-261 (263) alignment 
Range on Protein: 245-302
Range on HMM: 204-261/263.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
|||||||....||... . ...|.||||  |...|..|| ||||.|||.|.| |.||.
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 245-302 1.2e-17 59.5 In-house 204-261 (263) alignment 
Range on Protein: 245-302
Range on HMM: 204-261/263.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
|||||||....||... . ...|.||||  |...|..|| ||||.|||.|.| |.||.
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRB_pd Subfamily PTPRB 244-306 1.7e-17 58.4 In-house 226-288 (293) alignment 
Range on Protein: 244-306
Range on HMM: 226-288/293.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSE
 |||||||.....| .. . ...  ||||| |...|..| ..|||..|| |.. .||. | ..
saGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_egg_pd Subfamily egg 336-451 1.9e-17 57.9 In-house 30-151 (307) alignment 
Range on Protein: 336-451
Range on HMM: 30-151/307.0
LSIQTATKTENRSKSRYTNSLPMDRNRVILQ-SRGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSnESCARYW-
 |..|| . .|. |.|       |  || |.  ||    ||. |  |||  .   || .| |. ||| ||| ||   .   ||||.   .| | |  || 
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywp

---SDKGVTTFGSVSVTTLSVSE
   ||  ||  ||. ...| | .
kaesdslvtvpGslrienlkvds
subfamily_PTPRG_pd Subfamily PTPRG 245-317 2.8e-17 57.1 In-house 229-301 (563) alignment 
Range on Protein: 245-317
Range on HMM: 229-301/563.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDS
|||||||... .|... . .. . |..|| . ..| .|...|||.|||.|.. |.|||. |..| ..|.. ..
aGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 385-489 7e-17 56.3 In-house 4-113 (199) alignment 
Range on Protein: 385-489
Range on HMM: 4-113/199.0
RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNE-SCARYWS--DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNN--PKARHVVKQYQFI
..|.|.|| |. .|.|||| || .     |||.|||.| .|   . ||.  . |.. .||.|||| ... .  .    . .|.|   | .   . .||| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

YWPTKAEERR
 |  |.    
swkekttpnv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 386-489 7.6e-17 56.1 In-house 4-112 (198) alignment 
Range on Protein: 386-489
Range on HMM: 4-112/198.0
HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNE-SCARYWS--DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNN--PKARHVVKQYQFIY
.|.|.|| |. .|.|||| || .     |||.|||.| .|   . ||.  . |.. .||.|||| ... .  .    . .|.|   | .   . .|||  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPTKAEERR
|  |.    
wkekttpnv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 342-483 8.5e-17 55.9 In-house 29-176 (297) alignment 
Range on Protein: 342-483
Range on HMM: 29-176/297.0
TKTENRSKSRYTNSLPMDRNRVILQsRGSSDSDFVNASFVK----GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYW--SDK
 .     | ||.. | .| .|| |. |. ...|..|| .|         ..| .| |. .|| ||| .| .    .|||.    .   . || ||  ...
krnsslrknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

GVTTFGSVSVTTLSVSERRgF----IeREIEVTQNnpKARHVVKQYQFIYWPT
.  . |.| |  ||      |    .  |...     . . ||.  ||. || 
erlkagdvvveflsstsde.fdrvil.telqliyr..sesrvvrhvqflswpd
Y_phosphatase Protein-tyrosine phosphatase 244-301 9.9e-17 56.5 Pfam-A 178-235 (235) alignment 
Range on Protein: 244-301
Range on HMM: 178-235/235.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
 |||||||.....| .. ......|||.. .|...|..|| |||. ||| |.| |.||
saGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 244-301 9.9e-17 56.5 In-house 178-235 (235) alignment 
Range on Protein: 244-301
Range on HMM: 178-235/235.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
 |||||||.....| .. ......|||.. .|...|..|| |||. ||| |.| |.||
saGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN12_pd Subfamily PTPN12 244-303 1e-16 55.7 In-house 215-277 (290) alignment 
Range on Protein: 244-303
Range on HMM: 215-277/290.0
CAGVGRTGVLLSIDSVVAEAKR---TKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 |||||||....|| |    |.   ..|.|.|  | ..|..|. .|||||||..|| ||.| .
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0051299 (Phosphotyrosine protein) phosphatases II 244-303 1.1e-16 56.7 In-house 227-286 (288) alignment 
Range on Protein: 244-303
Range on HMM: 227-286/288.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 |||||||... .| ..   .....||....| ..|. ||.|||| ||| ||| |.||.|
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 244-305 1.6e-16 55.9 In-house 212-276 (284) alignment 
Range on Protein: 244-305
Range on HMM: 212-276/284.0
CAGVGRTGVLLSIDSVVAEAKRTK---EVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFS
 |||||||... .| .    ....   .||....|...|. ||.|||| ||| ||| |.||.| .
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 340-509 1.6e-16 55.2 In-house 2-174 (239) alignment 
Range on Protein: 340-509
Range on HMM: 2-174/239.0
TATKTENRSKSRYTNSLPMDRNRVILQSRG-SSDSDFVNASFVK---GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSDK
.| |  |..| ||.| .  |..||.|.       ||..|||...   |  . .|.||  .  .  ||| |. . .  .||||    .  .. | .|| | 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

gVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEV-EDSFSGV
  . .  . ||         .| | . ..|      . | ||.|  || |   .   |  .| |  .. .||. | 
.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata..vlglrrkitkdslpga
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 341-509 2.3e-16 54.7 In-house 2-173 (239) alignment 
Range on Protein: 341-509
Range on HMM: 2-173/239.0
ATKTENRSKSRYTNSLPMDRNRVILQSRG-SSDSDFVNASFVK---GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSDKg
| |  |..| ||.| .  |..||.|.       ||..|||...   |  . .|.||  .  .  ||| |. . .  .||||    .  .. | .|| |  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

VTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEV-EDSFSGV
 . .  . ||         .| | . ..|      . | ||.|  || |   .   |  .| |  .. .||. | 
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata..vlglrrkitkdslpga
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 244-312 2.4e-16 54.6 In-house 219-288 (315) alignment 
Range on Protein: 244-312
Range on HMM: 219-288/315.0
C-AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQA
| ||||||| ....|.|. .|.  . .|.. .. ..||||  |||. ||| |.| |.||..   || |  
csaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaq
0040438 (Phosphotyrosine protein) phosphatases II 245-324 3.2e-16 54.9 In-house 218-297 (317) alignment 
Range on Protein: 245-324
Range on HMM: 218-297/317.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLMNLQE
|||||||... .. ..   .....||..  | ..|. ||..||| ||| |.| |.|| |   .|.. ||.. . |..|..
aGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli
subfamily_PTPN9_pd Subfamily PTPN9 244-302 3.5e-16 54.1 In-house 231-289 (297) alignment 
Range on Protein: 244-302
Range on HMM: 231-289/297.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
 ||.|||| . ..|  ... ...  ||..  |...|. | ...|| |||.| |.|||| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 341-519 4.8e-16 53.6 In-house 28-199 (267) alignment 
Range on Protein: 341-519
Range on HMM: 28-199/267.0
ATKTENRSKSRYTNSLPMDRNRVILQSrgsSDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSNesCARYWSDK--GV
   ..|. . |. ..|| | .||||.    .. ...|||.|.| .  . || || |. ||..||. ...|.. ..||.|    . |    ..|  |    
siaeknqernrlddnlpyddtrvilrt...keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..irlfwPPkmgqa

TTFGSVSVTTLSVSERRGFIEREIEVTQNNPKArHVVKQYQFIYWPTKAEERrdraPYLLNLMTEVEDSFsGVAEGFPVLVHC
  .  ..|      |   .    .|.  .|  | | |  | .  |  .....    |||  |.  .         . |..|.|
kkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintnnk....pylkplfgilaknq.lengnrPlvvac
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 343-451 6.7e-16 52.7 In-house 49-161 (310) alignment 
Range on Protein: 343-451
Range on HMM: 49-161/310.0
KTENRSKSRYTNSLPMDRNRVILQSRGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLN-DDDKSNESCARYWSDKGVT-T
 ...  | ||.. . .|  || |.   |   |.. | .||   .|  || .| |.  |. ||| |...     |..|    ..    |  ||   ||| |
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

FGSVSVTTLSVSE
.| . || || | 
ygcirvtnlsess
PTPc_DSPc_SM00012 245-301 6.8e-16 53.7 In-house 48-105 (105) alignment 
Range on Protein: 245-301
Range on HMM: 48-105/105.0
AGVGRTGVLLSIDSVVAEAKRT-KEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
|||||||..  .| ..   ... |||||| .|...|. || ||||.||| |.| |.||
aGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyralle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 244-301 7.1e-16 53.1 In-house 179-237 (237) alignment 
Range on Protein: 244-301
Range on HMM: 179-237/237.0
C-AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
| |||||||..| ||... .||  | |||. ||  . ..|||..|||.|| |.. ..||
csagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0036941 (Phosphotyrosine protein) phosphatases II 245-314 9.8e-16 53.4 In-house 216-288 (297) alignment 
Range on Protein: 245-314
Range on HMM: 216-288/297.0
AGVGRTGVLLSIDSVVAEAK---RTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASH
|||||.|... .| ..   .   ....|||. .| |.|. || .||| ||| |.| |.|| | . .|..... 
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 244-303 1.3e-15 53.1 In-house 213-272 (273) alignment 
Range on Protein: 244-303
Range on HMM: 213-272/273.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 |||||||... .| ..   .....||.. .| ..|. ||.|||| ||| |.| |.|| |
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 245-320 1.3e-15 52.3 In-house 228-303 (307) alignment 
Range on Protein: 245-320
Range on HMM: 228-303/307.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDSTLM
|||||.|.....||.. . |  ..||||  | ..|..|. .||  |||.|.| |.|.     || ..  ...... 
aGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 244-306 1.5e-15 52.4 In-house 232-295 (319) alignment 
Range on Protein: 244-306
Range on HMM: 232-295/319.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE-ALFSE
 |||||||| . .| ..   |. | ||.. .|  .||.|. .||   || |.|.|.||  ||. 
saGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_CG42327_pd Subfamily CG42327 345-447 1.9e-15 51.3 In-house 27-138 (319) alignment 
Range on Protein: 345-447
Range on HMM: 27-138/319.0
ENRSKSRYTNSLPMDRNRVILQSRGSSDSD-FVNASFVKGIRH---RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-ESCARYWSDK----G
  . |||. |..|.   ||.||. |. |.| ...||.|.| .     .|..|... .. .||| .| .    .|| | |  .   . ||.|.  |    .
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

VTTFGSVSVTTL
  ..| . ||  
tslyGdilvtlk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 244-306 2.2e-15 51.9 In-house 196-259 (284) alignment 
Range on Protein: 244-306
Range on HMM: 196-259/284.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE-ALFSE
 |||||||| . .| ..   |. | ||.. .| ..||.|. .||   || |.|.|.||  ||. 
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_PTPN13_pd Subfamily PTPN13 244-303 2.3e-15 51.6 In-house 210-269 (273) alignment 
Range on Protein: 244-303
Range on HMM: 210-269/273.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 ||.||.|.|..|| |.   .| ||.|.   | |.|. |  .||||.|| ||| |.||.|
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_eak_pd Subfamily eak 333-483 2.6e-15 50.6 In-house 39-191 (332) alignment 
Range on Protein: 333-483
Range on HMM: 39-191/332.0
CTLLSIQTATKTENRSKSrYTNSLPMDRNRVILQSRGSSDSDFVNASFV--KGIRHRFITTQMPMPNTVADFWAMVIDYH-PSIIVMLNDDDKSNESCAR
  ||||. ....|.  .    . .| ||. | | |       ..||| .    . ...| | ..  . |  || ||.. . |.|. .|.| ..  |   .
qrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdk

YWSDKG--VTTFGSVSVTTLSVSERRGFIEREIEVTQNNpkARHVVKQYQFIYWPT
|. ||.  .  || . |.. .  .|  .  | .|... |    | |. |..  |  
yfpdktreelkfGildverkefvkrniletrllelskGn..ethrvlhykvfGwte
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 244-304 2.8e-15 51.2 In-house 216-277 (281) alignment 
Range on Protein: 244-304
Range on HMM: 216-277/281.0
CAGVGRTGVLLSIDSVVAEAKRT-KEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALF
 |||||||. ...| .| ..... .|.|.   | ..|..| .||||  ||.||| |||.|| 
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0043147 (Phosphotyrosine protein) phosphatases II 371-519 3e-15 51.8 In-house 3-107 (172) alignment 
Range on Protein: 371-519
Range on HMM: 3-107/172.0
SDSDFVNASFVKGIR--HRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDdksnescarywsdkgvttfgsvsvttlsvserrgfiereievTQNNPK
..||..|||.... .  .||| || |..||.||||.|. ... ..||.|..                                           . . ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

ARHVVKQYQFIYWPTKAEErrdRAPYLLNLMTEVEDSFsGVAEGFPVLVHC
  . . ||....||         . .||...  ... .  . .| ||||||
lerlgiqylylpwpDhgvp...llellleflefidell.alspggpvlVHC
subfamily_CG7180_pd Subfamily CG7180 245-305 5.8e-15 49.7 In-house 232-292 (296) alignment 
Range on Protein: 245-305
Range on HMM: 232-292/296.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFS
 |..|.|| |.||  .  .....|||.|..| ..|..|| .|...|.| ..|  .|||.. 
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 244-318 7.3e-15 49.6 In-house 207-281 (283) alignment 
Range on Protein: 244-318
Range on HMM: 207-281/283.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHFDST
 .|.|||.|.... . | .|.    ||.|  |  ||..|. .|||..|| .|. .|||  .  ||.| |  . ||
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
0046846 (Phosphotyrosine protein) phosphatases II 369-519 9.9e-15 50.2 In-house 8-116 (176) alignment 
Range on Protein: 369-519
Range on HMM: 8-116/176.0
GSSDSDFVNASFVKGirHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSDkgVTTFGSvsvttlsvserrgfiereievtqnnp
   |.|..||... |  .|.|.|| |.|.|.|||..|. ... ...|.|... ...  .|..||..  ....|                           
ldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

karhvvkqyQFIYWPTKAEERRDRaPYLLNLMTEVEDSFSGvaeGFPVLVHC
         |....|.      |   .||.|. ....  .    | ||||||
.........qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHC
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 339-519 1.3e-14 48.9 In-house 34-216 (307) alignment 
Range on Protein: 339-519
Range on HMM: 34-216/307.0
QTATKTENRSKSRYTNSLPMDRNRVILQSRGSSdSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVML-NDDDKSNESCARYWSD-K
.. . . |  | ||..   .|..|....  | . ||.. | ..      ..|| .| |. ||. .||||.|. .   ..|| .  . ..  | .||   .
tveafsantdknryqdvkcqdkgrivvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

GV-TTFGS----VSVTTLSVSeRRGFIEREIEVTQNN---PKARHVVKQYQFIYWPTKAEERRDRApyLLNLMTEVEdsfsgvAEGFPVLVHC
|   .||.    .||. | .  .    |  |.||. .    .    ....|.  || .   . . .   .||.  |.       .  ||.|||
gqklvfgeapntisvanlgak.klapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt..ainlleavr......ydtnpvvvhc
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 338-484 1.5e-14 48.2 In-house 88-233 (244) alignment 
Range on Protein: 338-484
Range on HMM: 88-233/244.0
IQTATKTENRSKSRYTNSLPMDRNRVILqSRGSSDSDFVNASFVK--GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNdddkSNESCARYWSDKG
.. | . .|  |.|   .||.| ||| | |.||    ..|||||   |    .| || |. .|  ||| |... |  ..|.|     | |    || |  
mkdafnpnnswknregaglpfdfnrvpl.skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg....sveeedeywpdse

VTTFGSV--SVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTK
   .     .||     | .     ..|.  .  ..   .  .|   ||. 
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsd
0039614 (Phosphotyrosine protein) phosphatases II 245-303 1.9e-14 49.3 In-house 231-289 (297) alignment 
Range on Protein: 245-303
Range on HMM: 231-289/297.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
|||||||... .. ..   .....||..  |...|. ||..||| .|| |.| |.|| |
aGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 244-300 2.2e-14 48.2 In-house 209-265 (274) alignment 
Range on Protein: 244-300
Range on HMM: 209-265/274.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVL
 ||.||||. ..|.  | . .... ||... |...|..|  ||||.||| ... |. 
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 376-504 4.3e-14 47.0 In-house 83-212 (301) alignment 
Range on Protein: 376-504
Range on HMM: 83-212/301.0
VNASfvkGIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSDKGVTTF--GS--VSVTTLSVSERRGFIEREIEVTQNNPK-A
...|   |  ||||.|| |..||  |||||.. |.   ||||    .| .| |. | . |   ..  |   . ...  .  .   ..|..||.    | |
ipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfa

RHVVKQYQFIYWPTKAEERRDRApyLLNLMTEVED
 . |  ||.  |. .   .      | .||  | .
trtvthyqysewtdrgvPkshae..lfdlmelvkk
0043336 (Phosphotyrosine protein) phosphatases II 245-301 8.9e-14 47.1 In-house 219-275 (278) alignment 
Range on Protein: 245-301
Range on HMM: 219-275/278.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
|||||||... .. ..  ......||..  |...|. || .||| .|| |.| |.||
aGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 245-302 1.4e-13 46.7 In-house 243-303 (307) alignment 
Range on Protein: 245-302
Range on HMM: 243-303/307.0
AGVGRTGVLLSIDSVVAEAKRTKE---VDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
|||||||... .. .    .....   ||..  |...|. || .||. ||| |.| |.|| 
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 244-301 1.5e-13 45.4 In-house 205-262 (270) alignment 
Range on Protein: 244-301
Range on HMM: 205-262/270.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
 |||||||.|. .| .|   ..||.||.   ....|..|. .||. |||.|.| ||.|
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 387-485 1.6e-13 44.8 In-house 237-332 (440) alignment 
Range on Protein: 387-485
Range on HMM: 237-332/440.0
RFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDdkSNESCARYWSD-KGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNpkARHVVKQYQFIYWPTKA
 ||.||||.  || ||| .| ||. | |.|||.    . .|. ||       |||  .|      .      | .|.  ..    | ..|..   |||  
afiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfevqtwptwi
0040439 (Phosphotyrosine protein) phosphatases II 245-302 2.8e-13 45.5 In-house 188-245 (249) alignment 
Range on Protein: 245-302
Range on HMM: 188-245/249.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
|||||||... .. ..   .....||.. .|...|. ||..||. ||| |.| |.|| 
aGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0049260 (Phosphotyrosine protein) phosphatases II 385-519 2.8e-13 45.3 In-house 8-96 (152) alignment 
Range on Protein: 385-519
Range on HMM: 8-96/152.0
RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK-SNESCARYWsdkgvttfgsvsvttlsvserrgfiereievtqnnpkarhvvkQYQFIYWPT
 ..|| || |.|||.|||| |. ... ..||||....    . |..|.                                           ||....|| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpD

KAEERRDRAPYLLNLMTEVEdsfsGVAEGFPVLVHC
      .   . |.|. |         .| ||||||
hgvpdlsqlllflllfiekl....aldkggpvlVHC
0042113 (Phosphotyrosine protein) phosphatases II 245-301 4.7e-13 44.6 In-house 185-241 (245) alignment 
Range on Protein: 245-301
Range on HMM: 185-241/245.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
|||||||... .. ..  ......|...  | ..|. || .||| .|| |.| |.||
aGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN3_pd Subfamily PTPN3 244-302 9.2e-13 42.7 In-house 216-274 (280) alignment 
Range on Protein: 244-302
Range on HMM: 216-274/280.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
 ||.||||||. ..  .|   ....| .   |..||. |  .|||..||.||  |.|..
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 338-435 1.2e-12 42.2 In-house 40-138 (305) alignment 
Range on Protein: 338-435
Range on HMM: 40-138/305.0
IQTATKTENRSKSRYTNSLPMDRNRVILqsRGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVML-NDDDKSNESCARYWSDK
...  ..... | || .   .|.||| |  .|.   ... | .|      .||| || |. .| |||| | .. .   | || |  .|  . |. |.. |
mkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

G
 
d
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 243-315 1.3e-12 41.9 In-house 219-291 (439) alignment 
Range on Protein: 243-315
Range on HMM: 219-291/439.0
GCAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTRIQASHF
  ||||||| ....|  . . |  ..||| | |. .|..|  |||.  || |.| |||| .   |. ..  .|
csagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
0036282 (Phosphotyrosine protein) phosphatases II 373-519 1.5e-12 43.0 In-house 2-111 (174) alignment 
Range on Protein: 373-519
Range on HMM: 2-111/174.0
SDFVNASFVKG--IRHRFITTQMPMPntvadFWAMVIDYHPSIIVMLNDDDKSN-ESCARYWSDkgvttfgsvsvttlsvserrgfiereievtqNNPKA
||. |||....  |  |.| .| |..     ||.|. ... ...|||..    . . | .||..                               .    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

RHVVKQYQFIYWPTKAEERRDRapyLLNLMTEVEDSFSGvAEGFPVLVHC
.. . ||... ||   .   .    ||... .||. .|   .| ||||||
erlgiqylylpwpDhgvpdlsi...llefvkfveealse.dpggpvlVHC
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 244-303 2.1e-12 41.2 In-house 5-64 (69) alignment 
Range on Protein: 244-303
Range on HMM: 5-64/69.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
..| |||| ...|   .|  |  | ||||  |  ||. || ||  ...| |.. |. |||
ssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 245-309 2.1e-12 41.7 In-house 220-284 (287) alignment 
Range on Protein: 245-309
Range on HMM: 220-284/287.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDTR
..|||........  . ..|.   .|.|  . ..|. .| .||| |||.|.. .||| | | .|.
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 245-305 2.3e-12 41.4 In-house 225-285 (290) alignment 
Range on Protein: 245-305
Range on HMM: 225-285/290.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFS
..|||..|.....  .  .| .  .|.|  . ..|. .| .|||..|| ...  ||..| |
dtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 244-303 2.5e-12 41.0 In-house 6-65 (69) alignment 
Range on Protein: 244-303
Range on HMM: 6-65/69.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 .| |||| ...|   .|  |  | ||||  |  ||. || ||  . .| |.. |. |||
ssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
0051082 (Phosphotyrosine protein) phosphatases II 373-519 3.7e-12 41.6 In-house 3-99 (151) alignment 
Range on Protein: 373-519
Range on HMM: 3-99/151.0
SDFVNASFVKGIrhrFITTQMPMPntvaDFWAMVIDYHPSIIVMLNDDDKSNeSCARYWSDKGvttfgsvsvttlsvserrgfiereievtqnnpkarhv
||. |.|.| |    .. ...|..    ||.... ... . ||.|....  .  |..|. . |                                     
sdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg.....................................

VKQYQFIYWPTKAEERRDRAPYLLNLMTEVEDsfsgvAEGFPVLVHC
.. ... .. ...    .  . .|... ...|      .. ||||||
ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHC
0045098 (Phosphotyrosine protein) phosphatases II 245-302 3.9e-12 41.6 In-house 215-271 (278) alignment 
Range on Protein: 245-302
Range on HMM: 215-271/278.0
AGVGRTGVLLSIDSVVAEAkrTKEVDIFGYVSKMRQNRPY-MVQTKEQYTFVYVAVLEA
|||||||.|  .. .       . ||.. .|...|. ||. .||..||| |.| ..|| 
aGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_PTPN14_pd Subfamily PTPN14 244-303 4.1e-12 40.7 In-house 237-296 (300) alignment 
Range on Protein: 244-303
Range on HMM: 237-296/300.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 |||||||||.  | ..|  .  .|.||   ....|. | ..|||  ||.||| .... |
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 348-435 5.3e-12 39.7 In-house 50-157 (349) alignment 
Range on Protein: 348-435
Range on HMM: 50-157/349.0
SKSRYTNSLPMDRNRVILQ---------------SRGSSDSDFVNASFVKGI----RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKSN-ESC
.| || . || .  ||.|.               | ..   |..|| ..|       ...|.||.|.| || ||. ...     ... ||||.. . | |
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

ARYWSDKG
 .|| .  
diywqels
subfamily_PTPN6_pd Subfamily PTPN6 244-301 6.9e-12 40.0 In-house 235-295 (306) alignment 
Range on Protein: 244-301
Range on HMM: 235-295/306.0
CAGVGRTGVLLSIDSVVAEAKR---TKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLE
 ||.|||| .. || ..   ..     ..||   | ..|. |  .|||..|| ||| |. .
saGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_PTPRN_pd Subfamily PTPRN 243-302 8.4e-12 39.4 In-house 231-291 (297) alignment 
Range on Protein: 243-302
Range on HMM: 231-291/297.0
GCAGVGRTGVLLSIDSVVAEA-KRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
. .|.||||| . || |..   |  ||.||   . ..|..|| .|.||.|. |.. || | 
csdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 244-299 9.3e-12 39.5 In-house 200-255 (267) alignment 
Range on Protein: 244-299
Range on HMM: 200-255/267.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAV
 .||||.| .| ||| .  ||.   .||| .. |.|. |. .|.|||.| ...  .
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
0051429 (Phosphotyrosine protein) phosphatases II 245-309 2e-11 39.6 In-house 159-230 (272) alignment 
Range on Protein: 245-309
Range on HMM: 159-230/272.0
AGVGRTGVLLSIDSVVAEAKRTKEVD--------IFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAlFSEDTR
||..|||..  .. ...   ..  ||        ....|...|. ||..||| ||| |.| |.||. . . . 
aGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel.lrslls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 244-303 2.8e-11 37.8 In-house 236-295 (297) alignment 
Range on Protein: 244-303
Range on HMM: 236-295/297.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEAL
 |||||.||..  | ..|  .. .  |.   .|..|..|. .||| ||....| |||. |
saGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
0037934 (Phosphotyrosine protein) phosphatases II 245-301 3.5e-11 38.6 In-house 187-240 (243) alignment 
Range on Protein: 245-301
Range on HMM: 187-240/243.0
AGVGRTGVLLSIDSVVAEAkrtkEVDIFGYVSKMRQNRPY-MVQTKEQYTFVYVAVLE
|||||||.|. .. .        .||.. .| ..|. ||. .||| .|| |.| |.||
aGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 346-433 4.2e-11 37.0 In-house 55-144 (305) alignment 
Range on Protein: 346-433
Range on HMM: 55-144/305.0
NRSKSRYTNSLPMDRNRVILQSRgSsDSDFVNASFVKGI---RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYWSD
. .| ||..    |.. | |.   |  ||.. | .|       .||| .| |. .|. .|| |||. .   ||||    .  .  ||.||  
aitknryqdvpcqdqsavkldkp.s.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa
0036282 (Phosphotyrosine protein) phosphatases II 245-296 7.3e-11 37.5 In-house 113-163 (174) alignment 
Range on Protein: 245-296
Range on HMM: 113-163/174.0
AGVGRTGVLLSIDSVVAEAKrTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVY
|||||||.|  .. .    . .. ||.. .| ..|. ||.|||| .|| |.|
aGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 343-519 7.6e-11 36.7 In-house 16-198 (290) alignment 
Range on Protein: 343-519
Range on HMM: 16-198/290.0
KTENRSKSRYTNSLPMDrNRVILQSRGSS-DSDFVNASFVKG-IRHRFITTQMPMPN-------TVADFWAMVIDYHPSIIVMLNDDDKSNE-----SCA
  ..  . |....| .. .||.|.  |.   .|.. |..|.     |.| || |  .       |. .|| |. . .   .||| . .. ..     .||
vkkhemdqRlevpLvea.trvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

RYWSDK--GVTTFGSVSVTTLSVSERRGFIEREIEVTQNNpKARHVVKQYQFIYWPTKAEERRdrAPYLLNLMTEVEDSfsgvaeGFPVLVHC
.|  ..  .  .|. ..|   |  .  ....||..|. .. .  . |. ...  | .   ..      ||.|.  |. |      . ||.|||
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqed..tktllsliqkvkas......ktpvivHc
subfamily_PTPN23_pd Subfamily PTPN23 244-302 1.1e-10 35.9 In-house 220-279 (288) alignment 
Range on Protein: 244-302
Range on HMM: 220-279/288.0
CAGVGRTGVLLSIDSVVAEAKRTKE-VDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
 ||||||||.  . ..|.| .. .  .||   ||..|..| .|||.|||. |.| |||||
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 345-484 1.7e-10 35.3 In-house 34-180 (285) alignment 
Range on Protein: 345-484
Range on HMM: 34-180/285.0
ENRSKSRYTNSLPMDRNRVILQSRgssDSDFVNASFVKGI---RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSDK--GVTT
 |    ||..   ..  ||.|. .   | |.. ||...     .  .|||| |.|.|..||| |. . . . ..||    .   | || |. .|   |  
anpdlnryadvrcieetrvvlknh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

FGSVSVTTLSVSER--RGFIEREIEVTQNNPKAR--HVVKQYQFIYWPTK
||   .|   . |    | |   . |.. .  .     ... |  .|| .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdq
subfamily_PTPN1_pd Subfamily PTPN1 243-311 2.3e-10 34.7 In-house 208-281 (290) alignment 
Range on Protein: 243-311
Range on HMM: 208-281/290.0
GCAGVGRTGVLLSIDSVVAEAKRTKE---VDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA--LFSEDTRIQ
  ||.||.| .  .|..... .....   |||   . ..|. |  ..||..|  | |.|.||   .  .|. .|
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 344-422 4.6e-10 33.6 In-house 45-119 (303) alignment 
Range on Protein: 344-422
Range on HMM: 45-119/303.0
TENRSKSRYTNSLPMDRNRVILqsrgsSDSDFVNASFVK-GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDK
 .|  | |... . .|  .| |     ||| .. ||...   ... | ||.|.. | |||| |.|. .   ...|  | .
vknmdknrfvdvicldhskvkl.....sdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdse
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 245-305 5.3e-10 33.5 In-house 235-295 (301) alignment 
Range on Protein: 245-305
Range on HMM: 235-295/301.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFS
..|.|.||  |..  .  .|.   ||.|. .  .|...| .|.| ||||..| .. . |  
dtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 343-435 5.9e-10 33.3 In-house 34-131 (281) alignment 
Range on Protein: 343-435
Range on HMM: 34-131/281.0
KTENRSKSRYTNSLPMDRNRVILQS--RGSSDSDFVNASFVKG--IRHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDDDKS-NESCARYWSDKG
.  |  | ||.|   .|  || |.        .|.. | ...   ... .| || |  .| |||| |. .   . |||| .  ..  | || |.  . 
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna
0049260 (Phosphotyrosine protein) phosphatases II 245-296 6e-10 34.5 In-house 98-143 (152) alignment 
Range on Protein: 245-296
Range on HMM: 98-143/152.0
AGVGRTGVLLSIDSVVaeakrtKEVDIFGYVSKMRQNRPYMVQTKEQYTFVY
|||||||.|  .. .       . |... .|. .|. ||..|....|. |.|
aGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0043147 (Phosphotyrosine protein) phosphatases II 245-296 6.7e-10 34.4 In-house 109-154 (172) alignment 
Range on Protein: 245-296
Range on HMM: 109-154/172.0
AGVGRTGVLLSIDSVVaeakrtKEVDIFGYVSKMRQNRPYMVQTKEQYTFVY
|||||||.|  .. .       . ....  |. .|. ||..||...|| |.|
aGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 356-484 8.7e-10 33.0 In-house 3-124 (130) alignment 
Range on Protein: 356-484
Range on HMM: 3-124/130.0
LPMDRNRVIlqsrgssDSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNdddkSNESCARYWSDKGVTTFGSVSVTtLSVSERR
|... .|.        . ...|||||  .     .. || |. .|  ||| |... .  ..|.|     | |    || |     .    .. .....| 
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg....sveeedeywpdsePlewyeedii.vtltdrd

GF--IE-REIEVTQNNPKARHVVKQYQFIYWPTK
.|  |.  ..|. ..  .. . .  .|   ||. 
efknikasnleiesdlneshqaltmfqisnwpsd
0041856 (Phosphotyrosine protein) phosphatases II 245-307 1.1e-09 33.7 In-house 118-175 (182) alignment 
Range on Protein: 245-307
Range on HMM: 118-175/182.0
AGVGRTGVLLSIDSVVAEakrtkEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSED
|||||||.|  .. .        .|...  |. .|. || ||.| .|| |.. |.|| |   .
aGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_CG42327_pd Subfamily CG42327 245-299 1.5e-09 32.0 In-house 256-311 (319) alignment 
Range on Protein: 245-299
Range on HMM: 256-311/319.0
AGVGRTGVLLSIDSVVAEAKRT-KEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAV
 ||||||.... |  . . . . . |||   || .|..|   |.||||| |.|  .
dGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 245-300 1.8e-09 31.5 In-house 227-282 (302) alignment 
Range on Protein: 245-300
Range on HMM: 227-282/302.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVL
 |.|| |..|.   .| . .. ||. |   | ..|..|| .|.. .||...|.|.|
nGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 344-464 3.9e-09 31.0 In-house 41-160 (288) alignment 
Range on Protein: 344-464
Range on HMM: 41-160/288.0
TENRSKSRYTNSLPMDRNRVILQsrgsSDSDFVNASFV-KGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLNDD-DKSNESCARYW-SDKGVTT
 .| .. ||.|    |  || |.     |.||  |. |      ..|.| .| |.  |.  .| |...     ||||..  .|  |  | |. | .| ..
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

-FGSVsvtTLSVSERRGFIEREIEVTQ
 .| .      | ..|  |.. ..|. 
rigrl...ctvvkkkradidklvkvsl
0046846 (Phosphotyrosine protein) phosphatases II 245-301 5.2e-09 31.6 In-house 118-171 (176) alignment 
Range on Protein: 245-301
Range on HMM: 118-171/176.0
AGVGRTGVLLSIDSVVAEakrtKEVDIFGYVSKMRQNRP-YMVQTKEQYTFVYVAVLE
||.||||.|. .. .  |    | ....  ....|. || ..||| ||| |.| ..|.
aGigRtgtlvaayllele....kglsveealalvreqRplgavqtpeQyrflyefell
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 349-434 6.1e-09 30.0 In-house 46-131 (312) alignment 
Range on Protein: 349-434
Range on HMM: 46-131/312.0
KSRYTNSLPMDRNRVILQsrGsSDSDFVNASFVKGI--RHRFITTQMPMPNTVADFWAMVIDYHPSIIVMLND-DDKSNESCARYWSDK
  || |    || |  |   |  .  .. | |||      ||..|| |. ||.. || ...    . |..|    . ..| ||.| || 
lnrypniqcwdrgrftla..g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi
0044763 (Phosphotyrosine protein) phosphatases II 359-519 7.5e-09 31.0 In-house 3-117 (178) alignment 
Range on Protein: 359-519
Range on HMM: 3-117/178.0
DRNRVILQ-SRGSSDSDFVNASFVKgiRHRFITTQMPmpntvADFWAMVIDYHPSIIVMLNDDDKSN-ESCARYWSDKGVttfgsvsvttlsvserrgfi
||.||.|.  .|   ||. |||..    . ..... |     ||..... ... . ||.|....  . ..| .|| ..                      
drtrvllsnleglersdyinaseil..pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag....................

ereievtqnnpkarhvvkqYQFIYWPTKAEERRDRAPYLLNLMTEVEDSFSgvAEGFPVLVHC
                   .|....|.      |   ..|...  .|.  .   .| ||||||
...................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHC
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 398-506 1.6e-08 29.0 In-house 40-149 (255) alignment 
Range on Protein: 398-506
Range on HMM: 40-149/255.0
TVADFWAMVIDYHPSIIVMLNDDDK-SNESCARYWS--DKGVTTFGSVSVTTLSVSERRGFIEREIEVTQNNPKARHVVKQYQFIYWPTKAEERRDRapY
||. |. ...   .. .||| |    . | | .|.     .   .  |.|||   |    .  .||  |  . |  | || |..  |. |   .  |   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar..e

LLNLMTEVEDSF
.||..  | || 
ilnilkvvrdsk
subfamily_hpo-7_pd Subfamily hpo-7 397-489 3.8e-08 27.6 In-house 45-140 (263) alignment 
Range on Protein: 397-489
Range on HMM: 45-140/263.0
NTVADFWAMVIDYHPSIIVMLNDDDKS-NESCARYWS--DKGVTTFGSVSVTTLSVSErrGFIEREIEVTQ--NNPKARHVVKQYQFIYWPTKAEERR
.|.. |. ..    .. .||| |      | | .|.     .   .  |.|.|  | .    . . .|...  .. |  | ||.|..  |. | . . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel
0048076 (Phosphotyrosine protein) phosphatases II 245-300 7.9e-08 27.6 In-house 90-140 (145) alignment 
Range on Protein: 245-300
Range on HMM: 90-140/145.0
AGVGRTGVLLSIDSVVAeakrtKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVL
|||||||.|  .. .       . |...  . ..|. ||..|.. .|. |.| ..|
aGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 444-520 9e-08 25.9 In-house 252-326 (392) alignment 
Range on Protein: 444-520
Range on HMM: 252-326/392.0
VTTLSVSERRGFIEREIEVTQNnPKARHVVKQYQFIYWPTKAEERRDRAPYLLNLMTEVEDSFSGVAEgFPVLVHCL
...|| |       . . ....  || | | ||||  || .  ...  |  || |.  |  |     | | .|||||
lqdlstssdGdvrskqlkefrs.lkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskke.fsilvhcl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 345-416 1.7e-07 25.1 In-house 36-115 (347) alignment 
Range on Protein: 345-416
Range on HMM: 36-115/347.0
ENRSKSRYTNSLPMDRNRVILQSRG------SSDSDFVNASFVK--GIRHRFITTQMPMPNTVADFWAMVIDYHPSIIVM
 . || |  .   .|  ||.|               ..||| .|    .. .| || |.|.|| ||| ||   . . .| 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 243-308 2.2e-07 24.9 In-house 216-281 (312) alignment 
Range on Protein: 243-308
Range on HMM: 216-281/312.0
GCAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDT
  ||||||| |  |.|..|  .  .  ..      .|..|   |..  || ..  .||| |.|.  
csagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
0048179 (Phosphotyrosine protein) phosphatases II 245-297 3e-07 25.8 In-house 92-139 (144) alignment 
Range on Protein: 245-297
Range on HMM: 92-139/144.0
AGVGRTGVLLSIDSVVaeakrTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYV
|||||||.|  .. ..     .. ....  .  .|. ||..|.. .|. |.. 
aGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 245-300 3.1e-07 24.5 In-house 219-274 (287) alignment 
Range on Protein: 245-300
Range on HMM: 219-274/287.0
AGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVL
.|.||.|.||..  .|   . . .||.   | ..|. |  .||.  |. ..| |. 
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 392-484 3.7e-07 23.9 In-house 97-201 (302) alignment 
Range on Protein: 392-484
Range on HMM: 97-201/302.0
QMPMPNTVADFWAMVIDYHPSIIVMLNDDD-KSNESCARYWSDK--GVTTFGSVSVTTLSVSE-------RRGFIEREIEVTQN--NPKARHVVKQYQFI
 .|  .|.  .||.. .|. .|.| | .   . .. || |.|||  |. .||  .|.|.|| .       ...|    .|.. .  . | .. |.  .| 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

YWPTK
 || .
awpdh
0051082 (Phosphotyrosine protein) phosphatases II 245-300 4.9e-07 25.0 In-house 101-150 (151) alignment 
Range on Protein: 245-300
Range on HMM: 101-150/151.0
AGVGRTGVLLSIDSVVAEakrtkeVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVL
||.||||.|  .. .         |...  .. .|. ||..||...|. |.. |.|
aGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 221-308 5e-07 23.9 In-house 187-275 (285) alignment 
Range on Protein: 221-308
Range on HMM: 187-275/285.0
RAIIDVSMWCQLGLV-QVIAAMGGCAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSEDT
| .|..  | .     .   ..   ||||||  .. ||          .....  | .||  |   ||.. |. |.|| ..| .  |  
rpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 351-436 5.5e-07 23.4 In-house 39-127 (332) alignment 
Range on Protein: 351-436
Range on HMM: 39-127/332.0
RYTNSLPMDRNRVILQSRGSSDsDFVNASFVKGIRH--RFITTQMPMPN-TVADFWAMVIDYHPSIIVMLNDDDKSNESCARY-WSDKGV
|      .|..|| |  .   | || |||.| |  .   .| .| |. . |   || || . .||.|... | |. ..  | |  ||.|.
riphlycfdhsrvelapqdgkd.dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 339-387 7.7e-07 22.8 In-house 40-89 (440) alignment 
Range on Protein: 339-387
Range on HMM: 40-89/440.0
QTATKTENRSKSRYTNSLPMDRNRVILQ-SRGSSDSDFVNASFVKGIRHR
. |.  .|. |.|| | | .|..||.|.  .|  |||..|||...||  |
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 244-300 1.4e-06 22.3 In-house 270-341 (350) alignment 
Range on Protein: 244-300
Range on HMM: 270-341/350.0
CAGVGRTGVLLSIDSVVAE-------AKRTKEVD--------IFGYVSKMRQNRPYMVQTKEQYTFVYVAVL
 |||||||.|...||.. .        |. ...|        |.  | ..|. |  |||...|. |.| |.|
saGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
Herpes_gE Alphaherpesvirus glycoprotein E 115-207 1.5e-06 16.8 Pfam-A 332-427 (439) alignment 
Range on Protein: 115-207
Range on HMM: 332-427/439.0
PALSVTTLKIAPPPVSSAIGASV-GGAVGGIIFVLLLIVIVIIVVRRRRRKVPTR-TRENKPDPYMDLTPRPE-ADTTYQEMDITSTASSKRPEER
|| .... ..|.|  ..| .. . ....|... .|.....|...|..|||. ... . ...   |. |    . .| .. | .  . ..... ||.
patpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkayekrlspfspvYtsLPtnelvedvsedeesedeevdvdeeeea
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 343-385 6e-06 20.4 In-house 45-85 (95) alignment 
Range on Protein: 343-385
Range on HMM: 45-85/95.0
KTENRSKSRYTNSLPMDRNRVILQSRgsSDSDFVNASFVKGIR
   |  | |. | .| |  ||.| ..   |||..|| || |  
seanipknrflnifpydatrvvlttk..rdsdyinacfvdgya
fn3 Fibronectin type III domain 24-109 6.3e-06 19.4 Pfam-A 19-82 (85) alignment 
Range on Protein: 24-109
Range on HMM: 19-82/85.0
SWNGNVdVGEGPIIGYKVYVTTSDGNErntfiassgalmemessgivsSRKRRQEDEGLLMYNVTGLGDGQAYEIQISAVREGLNG
||.     |.||| ||.| . ...|.|                       |... ..    ...|||  |. ||... || .. .|
sWsppk.dgggpitgYeveyrekggge.....................ewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 244-306 6.9e-06 19.7 In-house 229-291 (302) alignment 
Range on Protein: 244-306
Range on HMM: 229-291/302.0
CAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEALFSE
 ||||||| |..|   .   .. |  |.   |  .|| |   ||...| ... . |  .|   
saGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 244-302 8.5e-06 20.0 In-house 217-276 (307) alignment 
Range on Protein: 244-302
Range on HMM: 217-276/307.0
CAGVGRTGVLLSIDSVVAEAKRTKE-VDIFGYVSKMRQNRPYMVQTKEQYTFVYVAVLEA
 |||||.| ...|  |     . ..  |.   | ..|..|.| .||. || ...  .|| 
saGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley