Gene SpurPTP-sf1-9 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP086_AA protein Get Run
SpurP086_AA_1282-1559 phosphatase_domain Get Run
SpurP086_AA_1573-1835 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1281-1722 9.6e-181 596.3 In-house 1-435 (515) alignment 
Range on Protein: 1281-1722
Range on HMM: 1-435/515.0
PIPLSDFPAFVQKNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMD
|.||..|||||.|||| |.| |||.|||  ||||||||...|||.||||||||||||.||.| ..||.|.|||||||.||||.  . |||||||||||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAktQRFLNQFHYTKWPDRDVPRNMSSLLDFI
||||...||||.||||||.|.||.|||| .|||.  .  . || | ||| |.| |.|| || . . ||.    | . |||.|.|||. ||.. |||| .|
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllkli

SEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRlarLQDI
 ||. ||.| . || ||||||||||||.|.|||||..||  . ||.| || .||| || .|||.||| |.|.||||.||  || ||| .||     |||.
kevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdh...lqdl

DRNSKGR-RTGMSVQFESIKILCPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNtqsSDFINASFVRGNHGRLITTEMPMPNTVADFWVMIL
     || |. |  .|...| ||||||||  |.| | .|.||.||||.|| . |||.| | .    |.|||| ..| |  ..||.||.| ||.||| |.|
hssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspd...hdyinasqmkgihctfmttqmplpttvsdfwsmvl

DYQPTAIIMLNDDNQRDKSCARYWFDNGMATFGYLSVLTLATT
. .|..|.|||| .| |||||.|| |     ||  || ||.|.
nnkpstivmlndksqndkscaqywpdansvqfgsysvstlsts
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1273-1571 6e-155 509.7 In-house 1-297 (297) alignment 
Range on Protein: 1273-1571
Range on HMM: 1-297/297.0
ESGPMERQPIPLSDFPAFVQKNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHprRYIASQ
|..|.||.|||||||...||||||...|.|||..||||||.|||||.|..||||.|||||||||||||.|||.||||||||.||||.....|  |.|..|
eespkerrpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittq

GPNKASMDDFWRMIWQENVATIAMVTNLSEGNKiKCRQYWPETSTTPllFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPR-
 |.||...|||.|...|.|.||.|.....|..| ||..||.....|.  |||..|.|.||....|..||.....|||||..|...|.....|||..|.| 
mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverk

-NMSSLLDFISEVRKDHEQNNS-PLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNY
 ..||||..|||||||..||.. ||..||.|||||||||.||||||.||||.| |||||.|.|.||.||..|||||||||||.||||.||||.|.|...|
dsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy

FT
|.
fe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1280-1596 4.3e-130 428.1 In-house 1-313 (315) alignment 
Range on Protein: 1280-1596
Range on HMM: 1-313/315.0
QPIPLSDFPAFVQKNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASM
||||...|||||.||||...| |||.|||. .||.|.||...|||.|||||||||.||.||.| ...|.|||||.|||.|.|... . |||||||.|||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKakTQRFLNQFHYTKWPDRDVPRNMSSLLDF
||||||..||.|.||.|||...||.|||||||||.  .    || | ||| |.| ...| .| .|.||..  ..| . ||..|.|||. |....|||| .
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllkl

ISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLarlQD
| ||. |..... .|..|||||||||||.|.||.||...||.. ||.| || ..|. || .|||.|.| |.|.||||.||  || |.| .|| .|   ||
ikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl...qd

IDRNSKGR-RTGMSVQFE
.  ...|. |. |. .||
lhtsvdgsgrskmtkefe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1589-1835 1.6e-120 396.7 In-house 21-270 (297) alignment 
Range on Protein: 1589-1835
Range on HMM: 21-270/297.0
TGMSVQFESIKILCPdpPASMIRNGTTAENK---PKSRYGNSLPSRVNRVMLRSVNTQ-SSDFINASFVRGNHGRLITTEMPMPNTVADFWVMILDYQPT
........|...||.  |...|...|.||.|   .|||| |.||....||.|..||.. .||..|||||.||. |||||.|||..||||||.|.||.|..
knrhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvs

AIIMLNDDNQRDKSCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDVIKQKKSARSLLKLIEEMREVYSTQNES
.|.||||||.|||.|||||.|.|..|||..||..|....|||||.|.|||..|. |.|.||.||||..||......|.||.||||||.|.|...|...|.
tivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
||.||||.|||||.|..|........ .|..|..|..||..|..|...|||.
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk
subfamily_PTPRD_pd Subfamily PTPRD 1279-1599 1e-116 385.9 In-house 2-320 (564) alignment 
Range on Protein: 1279-1599
Range on HMM: 2-320/564.0
RQPIPLSDFPAFVQKNR--HSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNK
..||| ......|.| .  ... |.||.... | .  . ..|.|..| .||||.||..||.||| |  .. |..||| ||||| ...... |||.||| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETsTtPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSL
 ...|||||.|..|..|| |.|.|.| .| || .||||. . .  .|..||.||. |. .  . |.| |.| | . .|  .|||.|.|||..|| .  ||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLAR
||.|..||. .|... |. .||||||||||. |.||...  .| .|.|||...|...|. |. ||||.||| |..||.||.| . || .... ....| .
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LQDIDRnsKGRRTGMSVQFESIK
|. ...  . . ||... |. ..
Laevee..dtemtgleleFqrLa
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1279-1587 3.5e-112 369.6 In-house 1-262 (392) alignment 
Range on Protein: 1279-1587
Range on HMM: 1-262/392.0
RQPIPLSDFPAFVQKNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKAS
||||| ..|||||.|||||..| ||| |||. .|||||||.|.|| .||||||||||||.||.| ...| |||||.|||.||||.  . |||||||| ||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMIWQENVATIAMVTNLSEGNkikcrqywpetsttpllfgditvelesvekcsggskrsfvlrkgKAKTQRFLNQFHYTKWPDRDVPRNMSSLLD
.||||||..||||.||||||.| ||.                                            | . .|   |||.|.|||.|||.  |||| 
lddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllk

FISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLARLQ
|| ||. |. |   || ||||||||||||.|.|||||. ||. ..||.| ||..||. || |||||||| |.| |||| ||  || ||| .|| .|. |.
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

didRNSKGR
     | |.
...tssdGd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1290-1596 1.2e-95 315.2 In-house 10-316 (318) alignment 
Range on Protein: 1290-1596
Range on HMM: 10-316/318.0
FVQKN--RHSTFFQEEFNDL-PEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMI
 |..     .....||.. | .. .   .. . ...|  |||| |||.||..||.|  |.....||| ||..|. ... . |||.|.|    ..|||||.
hvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmv

WQENVATIAMVTNLSEGNKIKCRQYWPETSttPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKD
|. | |.| |.|...|  |.|. .|||.    .  .|...|||..  ..|    |.| ... . . .|   |.|||.|||..|| . .||||.. .|.| 
WeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

H-EQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLARLQDIDRNSk
. .....|. .||||||||||| |..|...  .| ..|||.|..|...|. |. ||||..||.|.|...||.| | .| .  . ..||. .|.. | .| 
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpes.

GrRTGMSVQFE
| .| | ..|.
g.ttemdaefq
0050432 (Phosphotyrosine protein) phosphatases II 1272-1561 1.4e-95 315.5 In-house 16-302 (308) alignment 
Range on Protein: 1272-1561
Range on HMM: 16-302/308.0
PESGPMERQPIPLSDFPAFVQKNRHSTFFQEEFNDLPEANIYPQ-TVAKKQINFEKNRYKNILPYDSSRVQLailndDPDSDYFNASFIPSF--QHPRRY
..| ...  .... |.  ...|   .....|||..|..  .... .||... |..|||||.|||||.||| |     |..||| |||... .   .||..
dtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkf

IASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETST-TPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDR
|| ||| . ...|||||.|..|| .| |.|.| | ...|| ||||..   ..| .|..||.| |.|....  .| . |.. . .  |....|||| ||| 
IatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdh

DVPRNMSSLLDFISEVRKDHeqNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
.|| ....||||. .||| .  ...|  .||||||||||..|..| ...  .... ||.|. | |.|. ||.||||.|||.|.|.|.||||.. 
gvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0051299 (Phosphotyrosine protein) phosphatases II 1281-1558 3.2e-94 310.9 In-house 4-286 (288) alignment 
Range on Protein: 1281-1558
Range on HMM: 4-286/288.0
PIPLSDFPAFVQK--NRHSTFFQEEFNDLPEANIY-PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKA
.|.....  .|.|   .. |...|||..|.. ..  ....|... |.|||||..|||||.|||.|  |.....||| |||.|. ....|..|| ||| . 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

SMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPEtsTTPLLFGDITVELESVEKCSGGSKRSFVLRKG----KAKTQRFLNQFHYTKWPDRDVPRNM
...|||||.|..|| .| |.|.| | ...|| ||||.   ..| .|||||.| |.|....  .| . ...     . .. |. ..||||.||| .|| ..
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

SSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
..||||. .||| ......|  .||||||||||..|..| ...  .... ||....| ..|. ||.|||| |||.|||||.||||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1290-1570 7e-93 306.6 In-house 11-288 (317) alignment 
Range on Protein: 1290-1570
Range on HMM: 11-288/317.0
FVQKNRHsTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQE
.. |. . | ..|||.||.. .... .||... | .||||..|||||.|||.|  |. |.|||| |||... ....|..|| ||| . ...|||||.|..
dllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

NVATIAMVTNLSEGNKIKCRQYWPEtsTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQ
.| .| |.|.| | ...|| ||||.   ..| .||.||.| |.|...|   | . . . . ...|....|||| ||| .|| ....||||...||.  |.
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYF
...|. .||||||||||..|... ...  .... ||..  | ..|. ||..||| |||.|.|.|.||||.  .| .|.. .
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
subfamily_PTPRB_pd Subfamily PTPRB 1279-1561 3e-92 303.8 In-house 4-288 (293) alignment 
Range on Protein: 1279-1561
Range on HMM: 4-288/293.0
RQPIPLSDFPAFVQKNR--HSTFFQEEFNDLPEA-NIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPN
 .|| |..| ..|.|..    . |.||...| .  .   ...|....| .||||.|||||| |||.|| |.|...||| ||..|| .. || .||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

KASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETStTPLLFGDITVELESVEKCSGGSKRSFVLRKgkAKTQRFLNQFHYTKWPDRDVPRNMSS
  ..||||||.|.... .| |.|.| |. |.|| .|||... .| |.|||.|.| . |. .    |.. ..|  .|..| ..|.|.| ||| .|| . ..
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

LLDFISEVRKDH--EQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
||||. .||. .  .....|. .||||||||||..|..| .... ... .|||||.|...|..| ..|||..|| |....||..| ..
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPRA_pd Subfamily PTPRA 1274-1578 6.7e-92 302.9 In-house 6-315 (330) alignment 
Range on Protein: 1274-1578
Range on HMM: 6-315/330.0
SGPMERQPIPLSDFPAFVQKN--RHSTFFQEEFNDLPEANIYPQ-TVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIA
||. .  |.|. ..   ...     .  |.|||| || ..|     .|.|. | ||||. |||||| ||| |. ..  ..||| |||||  ...  ..||
sgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia

SQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTtpLLFGDITVELESVEKCSGGSKRSFVLR----KGKAKTQRFLNQFHYTKWPD
.||| . ...|||||||. . ||| |.|.| | .. || ||||.  .  . .|.|.||.| .. .   . | |...    . . |..| ..|||.| |||
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPd

RDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIP
  || .   .|... .|.| ..|. .|. .|||||||||| .|..|.|.   | ...||.|.||...|. ||.||||.|||.|.|...||| |  .| . 
vGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld

VNYFTSRLARLQ
|  . ..| .|.
vsslekhlqkly
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1285-1584 9.2e-92 302.5 In-house 8-309 (319) alignment 
Range on Protein: 1285-1584
Range on HMM: 8-309/319.0
SDFPAFVQKN--RHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDF
 ..   ...     .| ...||..| ||.    . |.|..| .||||.|||.|| .||.|. |.. ..||| ||||| ..|. ...|| |.| .  ..||
qeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSttPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKT-QRFLNQFHYTKWPDRDVPRNMSSLLDFIS
|||.|.|.. .. |.|.|.|  |.|...||||.   .  .| ..|.||. |. ..  .| . |.| ...   | . .|.||.||| |||..  ||||.. 
WrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllk

EVRKDHEQ-NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLARLQDI
..|| .|. .. |. .||||||||||  |..| ..   |.. ..|.| .||..|  |. |||..|||||.|||.||.. . .| | |. .  || .|.. 
rirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek

DRNS
. ..
vadt
0046845 (Phosphotyrosine protein) phosphatases II 1300-1563 4.8e-91 300.3 In-house 2-279 (284) alignment 
Range on Protein: 1300-1563
Range on HMM: 2-279/284.0
FQEEFNDLPEANIY---PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDD-PDSDYFNASFIPSF-----QHPRRYIASQGPNKASMDDFWRMIWQEN
..|||  |.  ...   . .||... |..|||||.|||||.||| |  |..| .||||.|||... .      .....|| ||| . ...|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VATIAMVTNLSEGNKIKCRQYWPETsTTPLLFGDITVELESVEKCSGGSKRSFVLRKGK-AKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHE-
| .| |.|.| | ...|| ||||..  ..| .||.||.| |.|....  .| . |.. .  .  |....||||.|||..|| ....||.|. .||. .| 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-QNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNK---LVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENT
  ...|  .||||||||||..|..| . .  ....    ||... |...|. ||.|||| |||.|||||.||||.. .|
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0036941 (Phosphotyrosine protein) phosphatases II 1294-1566 8.2e-91 299.7 In-house 10-285 (297) alignment 
Range on Protein: 1294-1566
Range on HMM: 10-285/297.0
NRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLailnDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVAT
.  . . .|    ||  .... .||... | ||||||.|||||..||.|    ||..|||.|||... ....|..|| ||| . ...|||||.|..|| .
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEK--CSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQ--
| |.|.| | ...|| ||||..   .| .||.||.| |||.  ...   | . . . . . .|....||||.||| .|| ...|||||| .||| ...  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

NNSPLFIHCSAGVGRTGVLITIDSVVSEAK---RNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIP
...|  .||||||||.|..|..| ...  .   ... |||. .| |.|. ||..||| |||.|.|||.||.|.. .| .|
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1291-1565 4.5e-90 296.9 In-house 20-297 (298) alignment 
Range on Protein: 1291-1565
Range on HMM: 20-297/298.0
VQKNRHSTFFQEEFNDLPEANI----YPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMI
|.|. . | ...||. | . .       ..||.|. | .|||| .|...||||| |   ..| .||| ||||. ....   .||.|.| .... |||||.
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVATIAMVTNLSEGNKIKCRQYWPETSTTPllFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKD
..|...|| |.||| | .|.|. .|||.. ..   .|.|||.| | |. .   .| . . | | ...| . |.|.|.|||..||.|..|.||....||. 
teedigtiVmltnleeldktkyhkywPdegket..ygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

HEQNN-SPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAI
..|.  .|. ..|||||||.|  | ||||.  .|... ||.|  |  .|..||..|||.|||.|.||||||.| | |. |
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0047943 (Phosphotyrosine protein) phosphatases II 1290-1558 1.5e-89 295.4 In-house 4-272 (273) alignment 
Range on Protein: 1290-1558
Range on HMM: 4-272/273.0
FVQKNRHSTFFQEEFNDLPEANI-YPQTVAKKQINFEKNRYKNILPYDSSRVQLailnDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQ
...|  ..|...|||..|..  . .. .||... |..|||||.|||||.||| |    .|..||| |||... ....|..|| ||| . ...|||||.|.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

ENVATIAMVTNLSEGNKIKCRQYWPETSTT-PLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDH
.|| .| |.|.| | ...|| ||||..  . .| .|..||.| |.|....  .| . |.. . .  |. ..||||.||| .|| ...|||.|| .||| .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

EQ--NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
|.  .|.|  .||||||||||..|..| ...  .... ||..  | ..|. ||.|||| |||.|.|||.||||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1286-1558 1e-88 292.7 In-house 6-277 (278) alignment 
Range on Protein: 1286-1558
Range on HMM: 6-277/278.0
DFPAFVQKN--RHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFW
|.. ....      | ...|| .|.. .......|... |..|||||.|||||.|||.|  |. |.|||| |||... ...||..||.|||.. ...|||
dllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RMIWQENVATIAMVTNLSEGNKIKCRQYWPetsTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEV
||.|...| || |.|.| | ...|| ||||    ..| .||.||.| ..|....   | . . . . .  |. ...||..||| .|| ..|.||||. .|
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

RKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
|.  | .|.|. .||||||||||..|... ... ..... ||..  |...|. ||..||| .||.|.|||.||||
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 1300-1558 1.9e-88 291.6 In-house 2-262 (263) alignment 
Range on Protein: 1300-1558
Range on HMM: 2-262/263.0
FQEEFNDLPEANIY-PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVT
..|||..| |..   . | |.|. | .|||||||||||..||.|   .....||| ||..|   .....||| ||| .  ..|||||.|.|.| .|.|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCS-GGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIH
. .| .|.|| .||||.| ..  ||.|.|.| .|||..    .| . |.| . ...|...|..|..|||..|| ...|.|.....|.|.......|. .|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
|||||||||...|||...|. ...| ||||  |...|..||.||||.|||.|.|||.|||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1300-1558 1.9e-88 291.6 In-house 2-262 (263) alignment 
Range on Protein: 1300-1558
Range on HMM: 2-262/263.0
FQEEFNDLPEANIY-PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVT
..|||..| |..   . | |.|. | .|||||||||||..||.|   .....||| ||..|   .....||| ||| .  ..|||||.|.|.| .|.|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCS-GGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIH
. .| .|.|| .||||.| ..  ||.|.|.| .|||..    .| . |.| . ...|...|..|..|||..|| ...|.|.....|.|.......|. .|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
|||||||||...|||...|. ...| ||||  |...|..||.||||.|||.|.|||.|||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1279-1574 6.1e-88 289.8 In-house 3-295 (315) alignment 
Range on Protein: 1279-1574
Range on HMM: 3-295/315.0
RQPIPLSDFPAFVQKNRHST--FFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNK
.||||| .. ..| ... ||   |..... .|  ...|  ||||  | .|||| ||..|| ||||| .|. ||.||| ||.||. ....|||||.|||| 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETsttPLLFGDITVELESVEKCSGGSKRSFVLRKGKakTQRFLNQFHYTKWPDRDVPRNMSSL
||..||||....|....| |.||| ||.| |. .|||.     ...| ||| . | |. .  . |..    |.    | . |.||| ||| .||.   .|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytipl

LDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRL
...|  |.. |... ... .|||||||||| .||.|.|. .|. ....|.. |. ..|| | .|||. |||.|.|.|.|| ..  .|.|  . .  | 
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqry
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1293-1556 2.2e-87 287.8 In-house 16-277 (288) alignment 
Range on Protein: 1293-1556
Range on HMM: 16-277/288.0
KNRHSTFFQEEFNDLPEAN-IYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENV
. |  | |.||.| |.. .    .|....  | .||||.||||||  ||.|  |.. ...|| |||.| . .. ..|||.|||. ....|||........
sarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

ATIAMVTNLSEGNKIKCRQYWPETsTTPLLFGDITVELESVEKCSGGSKRSFVLRkgKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNN
 ||.|.|.| ||.| || .|||..  .| ..|..||.| ....     .|.. |   | ||.. ..|..|. ||| .||..   ||.... |   .... 
stivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadt

SPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
 |. .||||||||||. |..| .. . .... .|..|.|.|.|..|...|||..|| |.||..|.
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0039614 (Phosphotyrosine protein) phosphatases II 1282-1560 8.5e-87 286.6 In-house 16-291 (297) alignment 
Range on Protein: 1282-1560
Range on HMM: 16-291/297.0
IPLSDFPAFVQKNRHSTFFQEEFNDLPEANIyPQTVAKKQINFEKNRYKNILPYDSSRVQLAILND-DPDSDYFNASFIPSFQH-PRRYIASQGPNKASM
.   |.  .. |   .|....|| .|.. .. ....|... | .|||||.|||||.|||.|  ... |.|||| |||... . . .|..||.|||.. ..
lsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

DDFWRMIWQENVATIAMVTNLSEGNKiKCRQYWPETSTtplLFGDITVELESVEKCSGGSKRSFVLRKgkAKTQRFLNQFHYTKWPDRDVPRNMSSLLDF
.|||||.|...| .| |.|.| | .. || |||||...    .||.||.| .||...|   | . ...   .  |....|.||.||| .|| ....||.|
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

ISEVRKDHEQ--NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
. .||. ...  .. |  .||||||||||..|... ...  .... ||..  |...|. ||..||| .||.|.|.|.||.|. 
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_PTPRK_pd Subfamily PTPRK 1296-1585 1.7e-86 284.9 In-house 20-304 (314) alignment 
Range on Protein: 1296-1585
Range on HMM: 20-304/314.0
HSTFFQEEFNDLPEAniypQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIA
..  |.||.. |.|       .|||. | ||||...||.|| |||.|  ...||.||| ||..| |...|. .|. ||| .  . ||||....|| |.| 
egygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MVTNLSEGNKIKCRQYWPETSTTpllFGDITVELESVEKCSGGSKRSFVLRK--GKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSP
|.|.| |  ..|| .|||| ...   .||| ||| ..|  .   .| | ..|   . . .| ..||....||| ||| .  .||... .| | .|... .
mltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

LFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLARLQDIDRNSK
. .||||| ||||. |.||.|.  ..|...||.|  | ..|....|||.|.|||||.|...||  |  .|||||  | .     . .| ...
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtn
0045450 (Phosphotyrosine protein) phosphatases II 1285-1559 4.4e-86 284.7 In-house 14-305 (307) alignment 
Range on Protein: 1285-1559
Range on HMM: 14-305/307.0
SDFPAFVQKNRHSTFFQEEFNDLPEANI---YPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDD-PDSDYFNASFI--------PSFQHPRRYIASQ
...  ....  . | ...||..|.. ..   .. ..|... | .|||||.|||||..||.|  |... .||||.|||..        ... ..|..|| |
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

GPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETsTTPLLFGDITVELESVEKCSGGSKRSFVLRKG-KAKTQRFLNQFHYTKWPDRDVPR
|| . ...|||||.|...| .| |.|.| | ...|| ||||..  ..| .|..||.| |.|...|   | . .    . .  |....||||.||| .|| 
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

NMSSLLDFISEVRKDHEQ--NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKL---VDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLL
....||||| |||| .|.  ...|  .||||||||||..|... . .  ....    ||..  |...|. ||..||. |||.|.|||.||.||
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_PTPN12_pd Subfamily PTPN12 1308-1561 7.9e-85 279.2 In-house 25-280 (290) alignment 
Range on Protein: 1308-1561
Range on HMM: 25-280/290.0
PEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIK
 . ..|......|. | .|||||.||||| |||.|   .....||| ||.||   . . .|||.|||  . .||||||||. ||  . |. .. | .|.|
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CRQYWPETSTTPLLFGDITVELESVEKCSGGskrsFVLRKGK---AKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGR
|..||||.  ..| ||...|.||. .... .    |..|  |    |..| ..|||||.|||..||....|||..|..||. .|....|| .||||||||
CerYWpeegeeelefgefevtleeekavddd....flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

TGVLITIDSVVSEAKRNKL---VDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
||..|.|| | .  |..|.   .|.|  | ..|. |. .|||||||..||.||.|.. .|
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1281-1578 2.3e-84 278.1 In-house 3-303 (305) alignment 
Range on Protein: 1281-1578
Range on HMM: 3-303/305.0
PIPLSDFPAFVQKNRH--STFFQEEFNDLPEAnIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKAS
.| |.|. |.....|   .. ...... |.|    .  | ||. | .|||.|.| ..| .|..|.  ....|||| |||.. ....  .||..||| |  
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRK-GKAKTQRFLNQFHYTKWPDRDVPRNMSSLL
..||||.|..| | || |.|.| ||.| ||||||||. | .  ||...|||.| .. |.  .| . . .  . | .| . |.. |.|||  ||.  .|||
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

DFISEVRKDHEQN-NSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLAR
..| .|.||.... . || .||||||||||| |..|  .  .|. . ||.|. . ..|..|..||||..|| |...|. |.. . .| | .. .. |. .
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LQ
|.
lk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1316-1560 7.5e-84 275.8 In-house 2-244 (250) alignment 
Range on Protein: 1316-1560
Range on HMM: 2-244/250.0
TVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIkCRQYWP-E
.||||  | ||||| .|...||||| |   . | .||| ||||. ...  . .||.||| .|.. |||||...|...|| |.|||.| .|  . |||| |
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

TSTTpllFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQ-NNSPLFIHCSAGVGRTGVLITIDS
....   .||.||.| | |. .   || ..| | | . .| . |.|.. |||. ||... . |.....|.. ..| .|.|. ..|||||||.|  |.||.
kaek...yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

VVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
|.  .|..| ||.| .. ..|. ||..|...||| ||||..|..| |
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
Y_phosphatase Protein-tyrosine phosphatase 1323-1556 1.1e-83 275.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 1323-1556
Range on HMM: 1-235/235.0
NFEKNRYKNILPYDSSRVQLailNDDPD-SDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLL
|..|||||.|||||..||.|   ..... ||| ||... ........||.||| | ...|||||.|||.| .|.|.|.| | .. || |||||.. ..| 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDITVELE-SVE-KCSGGSKRSFVLRKGKAKT-QRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEA
.|||.|||. ... ....   | . |.| |... .| ..|.|||.|||..||.. .||||.| .|.|..|....|. .||||||||||.....| .....
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
.... ||.. .|...|..||.|||. |||.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1323-1556 1.1e-83 275.7 In-house 1-235 (235) alignment 
Range on Protein: 1323-1556
Range on HMM: 1-235/235.0
NFEKNRYKNILPYDSSRVQLailNDDPD-SDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLL
|..|||||.|||||..||.|   ..... ||| ||... ........||.||| | ...|||||.|||.| .|.|.|.| | .. || |||||.. ..| 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDITVELE-SVE-KCSGGSKRSFVLRKGKAKT-QRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEA
.|||.|||. ... ....   | . |.| |... .| ..|.|||.|||..||.. .||||.| .|.|..|....|. .||||||||||.....| .....
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
.... ||.. .|...|..||.|||. |||.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Ptp69D_pd Subfamily Ptp69D 1291-1577 1.7e-81 268.7 In-house 13-305 (307) alignment 
Range on Protein: 1291-1577
Range on HMM: 13-305/307.0
V-QKNRHS-TFFQEEFNDLPEANIYPQT-VAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIW
. ...|..   ...|.. |.. .|  .| |..|. |  ||||..| ..|. ||.|. .| . |||| ||||| .... ...||.|.|  | ..||||||.
lksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia

QENVATIAMVTNLSEGNKIKCRQYWPETstTPLLFGDITVELESVEKCSGGSKRSFVLRKGKA-----KTQRFLNQFHYTKWPDRDVPRNMSSLLDFISE
. .| .| |..||.| |. || .|||.   .   .||| |.| | ||.|   .|.. . | |.     . .| . |.||| |.|  ||.   .||..|..
eqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

VRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLARL
||. ...|.||. .||||||||.|.....||.. . | .. |||| .| ..|. |. .||  |||.|.| |.|.|    .| . |. . ... ||
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1296-1559 4.5e-81 267.0 In-house 13-277 (281) alignment 
Range on Protein: 1296-1559
Range on HMM: 13-277/281.0
HSTFFQEEFNDLPEANIY-PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATI
... |.||...| ....  . | .|.. | .||||.||  || .||...  ... ..|| ||.|.|... ...|||.|||  ||...||.|.|...| .|
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

AMVTNLSEGNKIKCRQYWPETSTtPLLFGDITVELESVEKCSGGSKRSFVLrKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNN-SP
.|||.  |..|.|| .|||. ..  | .||.||. .. |. .   .| | | . .   .| ..|..||.|||  || . . ||.| .||.| .|...  |
vmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

LFIHCSAGVGRTGVLITIDSVVSEAKRN-KLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLL
| |||||||||||. |..| .|...... . .|.   | ..|..|  ||||  ||.||| |||..| 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0040439 (Phosphotyrosine protein) phosphatases II 1314-1559 1.2e-80 265.9 In-house 2-247 (249) alignment 
Range on Protein: 1314-1559
Range on HMM: 2-247/249.0
PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWP
. .||... | .||||..|||||.|||.| ||.. ..||| |||.|. ....||.|| ||| . ...|||||.|.... .| |.|.| | ...|| ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EtsTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQ--NNSPLFIHCSAGVGRTGVLITI
.   ..| .||.||.| |||....   | . | . . .. |  ....||.||| .|| ....||||| .||| .|.  ...|...||||||||||..|..
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLL
. ...  .... ||..  |...|. ||..||. |||.|.|||.||.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPRG_pd Subfamily PTPRG 1283-1565 2.3e-79 262.1 In-house 2-294 (563) alignment 
Range on Protein: 1283-1565
Range on HMM: 2-294/563.0
PLSDFPAFVQKNRH--STFFQEEFNDLPEANI---YPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDS-DYFNASFIPSFQHPRRYIASQGPNK
|...|   | .      . |.|||..| .  |    . . ..|. | .|||| ||..||.|||.|. | .  .. || ||..|  .|. . .||.||| |
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

ASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPEtsTTPLLFGDITVELESVEKCSGGSKRSFVLRK-----GKA-KTQRFLNQFHYTKWPDRDVP
  .||||||||..|||.| |.||| | .. || .|||.   ... .| ..| |.. |. .  ..|..|...     .|  .|..   |.||||||| .||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

RNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAI
      | |.    . ....  |. .||||||||||..| .|... . .... |..|||. .||  |...|||.||| |...|.|| ..|..| .
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel
0042113 (Phosphotyrosine protein) phosphatases II 1317-1558 1.5e-78 258.9 In-house 3-243 (245) alignment 
Range on Protein: 1317-1558
Range on HMM: 3-243/245.0
VAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPEts
||... | .||||..|||||..||.|   . |.|||| |||... .......||.||| . . .|||||.|.... || |.|.. | ...|| ||||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

TTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHE-QNNSPLFIHCSAGVGRTGVLITIDSVV
 ..| .||.||.| |.|....   | . . . . . .|. ...||. ||| .|| ....||||...|||  .  .| |...||||||||||..|... ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

SEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
. ..... |...  | ..|. ||..||| .||.|.|||.||.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1293-1590 3.6e-77 254.7 In-house 18-318 (325) alignment 
Range on Protein: 1293-1590
Range on HMM: 18-318/325.0
KNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMI--WQen
| .    |  ||. ||  .   ..|| |  | .|||.||....| ||| |  ..|||.|||.|||.. ...    ..|.| |. |...|.||..  |.  
kaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..

vATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQ-
 ... .|.|  ...| .| .|||.       || . |.| ..|. |   .| . ... |    | ..||..  |.|  |..  ..|. ..  | . .|. 
.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavserv

-----NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFTSRLARLQDidRNS
       .|. .|||||||||||.|.. |.. .   .  ||||||| |.|. ||.||.| .|| ..|||. |...| || .||. | ..|. ||.  || 
tantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqe..rnp

KGRRTG
  ..  
ltqkln
subfamily_PTPN6_pd Subfamily PTPN6 1295-1561 1.6e-75 248.9 In-house 23-300 (306) alignment 
Range on Protein: 1295-1561
Range on HMM: 23-300/306.0
RHSTFFQEEFNDLP---EANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAiLNDDPDSDYFNASFIP--SFQHPRRYIASQGPNKASMDDFWRMIWQE
 . . |.|||..|    . . . .. ..|. | ||||||||||.| .|| |.  .. |.||| ||..|   . .. ..|||.||  .. . |||||.|||
lekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

NVATIAMVTNLSEGNKIKCRQYWPETSTTPLlFGDITVELESVEKCSGGSKRSFVLR-KGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHE
|   | |.|.  | .| || .|||......  .|.|.|.  | .. .    |....  | |.|..| . |.|...||| .||.. . .|||...|.. .|
nsrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

QNN----SPLFIHCSAGVGRTGVLITIDSVVSEAKRNK---LVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
. .     |. .|||||.|||| .| || ...  ....    .||  .| ..|. |  .|||..||||||.|. .|. ..
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
0045098 (Phosphotyrosine protein) phosphatases II 1298-1559 3.3e-75 248.3 In-house 8-273 (278) alignment 
Range on Protein: 1298-1559
Range on HMM: 8-273/278.0
TFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQlailnddpdsDYFNASFIPSFqhPRRYIASQGPNKASMDDFWRMIWQENVATIAMV
 ...| .. |.  ...  |.| .  |..|||||.|||||.|||           || |||.|...  |...|| ||| .  ..|||||.|.... .| |.
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivml

TNLSEGNKIKCRQYWPEtsTTPLLFGDITVELESVEKCSGGSKRSFVLRKG----KAKTQRFLNQFHYTKWPDRDVPRNM--SSLLDFISEVRKDHEQ--
|.| |....|| |||||    .| .||.||.|.|.| ..   .| . ..      .  ..|.....||. ||| .|| .   .|.|... ..|. ...  
telvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------NNSPLFIHCSAGVGRTGVLITIDSVVSEAkrNKLVDIFGFVSKIRQSRPN-MVQTKEQYKFVYEAVLEYLL
           .. | ..||||||||||.|. .. . .    .. ||..  |...|. ||. .||..|||.|.||..||.||
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN9_pd Subfamily PTPN9 1286-1561 1.4e-71 235.9 In-house 5-293 (297) alignment 
Range on Protein: 1286-1561
Range on HMM: 5-293/297.0
DFPAFVQKNRHSTfFQEEFNDLPEANIYPQ-TVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWR
.. |.|......   ..|. .. . ..  . ...|.. | |||||...| ||..||.|| ...|. ||| ||.|.  ..... .|| ||| |  ..||||
elvayvkekgkrG.lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVR
|.|...| .| |.| . |  ..||.||||... .   |||..|.  .||. .   .|...... | . .| .  | .. |||  ||.. .||||....||
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

KDH-------------EQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
.               . .. |. .|||||.|||| .||.|  .|. ..   ||..  |...|. |  ..|| |||.| | ||||| |. 
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1299-1558 2.8e-71 234.8 In-house 6-268 (274) alignment 
Range on Protein: 1299-1558
Range on HMM: 6-268/274.0
FFQEEFNDLPEaNIyPQTVAKKQINFEKNRYKNILPYDSSRVQLA-ILNDDPDSDYFNASFIPSFQH-PRRYIASQGPNKASMDDFWRMIWQENVATIAM
 ...|| .||  |  .|   .   . .|||||.||| . ||| |    ..|.||.| || .|  ...  . |.| |||    ..||||||.||.|  | |
dlekeflelPl.nf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTNLSEGNKIKCRQYWPETSTT--PLLFGDITVELESVEKCSGGSKRSFVLRKGKAktQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNS--
.|.|.| |. || .|.|..  .     .||. .. |.. .. . | |..||.. .   .| .  . ||.|||...|.....|||.. ||....|..|   
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

-PLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
 |  .|||||.||||. |.|.  | . .... ||... |...|. |  ||||.|||.....|. .||
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPN3_pd Subfamily PTPN3 1316-1556 7.4e-71 233.3 In-house 34-273 (280) alignment 
Range on Protein: 1316-1556
Range on HMM: 34-273/280.0
TVAKKQINFEKNRYKNILPYDSSRVQLAilndDPDSDYFNASF----IPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQY
..|.|  | .||||..|||||. ||.|     . ..|| ||..    ||| .   ||||.||| . .. |||.|.|.... .| |.|.| |  ..|| ||
saarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPETSTTpLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITI
||||. . | .|...|..|. .. .    | .||.. ..| .| . |. |. ||| .|| . ...|.|...||| .. ...|. .|||||.|||||||..
WPetede.leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
.  ..   ... | .   |...|. | ..|||..||||| ||.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1298-1570 1.1e-70 233.5 In-house 34-303 (319) alignment 
Range on Protein: 1298-1570
Range on HMM: 34-303/319.0
TFFQEEFNDLPE--ANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIA
| .. ||. ...  .|   || |  . | .|||. |||..| ..|.|  |.    ||| ||||.  .|.. .|||.||| . ...|||||||. |..|| 
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MVTnlsegnKIKCRQYWPETSTTPllFGDITVELESVEKCSGGSKRSFVLRK-GKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDH--EQNNS
..|      | || ||||         .   |...|||...    |.. | . || | .| ..|||.  |||  ||   | |. ..  ||. .  |... 
llt......kdkcsqywplkivik..eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYF
.. .||||||||||| |..| ...  |..| ||.. ||  .|| |...||   ||||.| |.||  |  .. . .  |
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdf
0037934 (Phosphotyrosine protein) phosphatases II 1315-1557 1.1e-70 233.2 In-house 2-241 (243) alignment 
Range on Protein: 1315-1557
Range on HMM: 2-241/243.0
QTVAKKQINFEKNRYKNILPYDSSRVQLailnddPDSDYFNASFIPSFqhPrRYIASQGPNKASMDD----FWRMIWQENVATIAMVTNLSEGNKIKCRQ
...|... | .||||..||||| ||| |      ..|||.||..|. .  | |.||.||| . . .|    ||||.|.... .| |.|.| | ...|| |
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPetSTTplLFGDITVELESVEKCSGGSKRSFVLRKGK-AKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKD--------HEQNNSPLFIHCSAG
|||  ...   .||.||.| |.| ...   | ..|.  .  . .|.  ..||. ||| .|| ....||||..|||.         .. ...|. .|||||
ywp..gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGVLITIDSVVSEAkrNklVDIFGFVSKIRQSRPN-MVQTKEQYKFVYEAVLEY
|||||.||... . .    .  ||..  | ..|. ||. .||| .||.|.|||.||.
vgRtGtliaaylmllll..g..vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN13_pd Subfamily PTPN13 1299-1558 5.6e-70 230.7 In-house 12-269 (273) alignment 
Range on Protein: 1299-1558
Range on HMM: 12-269/273.0
FFQEEFNDLPEANIYPQT-VAKKQINFEKNRYKNILPYDSSRVQLAilnDDPDsdYFNASFIP--SFQHPRRYIASQGPNKASMDDFWRMIWQENVATIA
  .|||..| |     .. |.||. | .||||.|.|||| .||.|    |.    | |||.|     ..  .|||.|||   ...|||.|.|. ..  ||
qPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MVTNLSEGNKIKCRQYWPETSTTPLLFGD-ITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEqNNSPL
|||.  |..|.||..||||.   .|   . ..|||. |.| .| . |.. ... ...  | . .....|||| .||..  .|| |..|||. .. ...|.
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPi

FIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
 .|||||.||.|.||||| |.   .|.| .|.   | |.|. |  .||||.|| |||.|.|| |
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1313-1570 2e-69 229.3 In-house 15-267 (284) alignment 
Range on Protein: 1313-1570
Range on HMM: 15-267/284.0
YPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTnlsegnKIKCRQYW
  || |  . | .|||. .||..| ..|.|  |     ||| |||||  .|.. .|||.||| . ...|||||||. |..|| ..|      | || |||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PETSTTPllFGDITVELESVEKCSGGSKRSFVLRK-GKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDH--EQNNSPLFIHCSAGVGRTGVLI
|         .   |...|||...    |.. | . || | .| ..|||.  |||  ||   | |. ..  ||. .  |...... .||||||||||| |
plkivik..eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

TIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYF
..| ...  |..| ||.. || ..|| |...||   ||||.| |.||  |  .. . .  |
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1307-1558 1.5e-68 225.8 In-house 4-264 (270) alignment 
Range on Protein: 1307-1558
Range on HMM: 4-264/270.0
LPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQH-PRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNK
|.. .  .... .   . . |||..|||   .||.|. |..|. . |.|| ... |.. ...|||..|| .... .||||||.|.| .|.|.|.| | ..
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

IKCRQYWPETSTT--PLLFGDITVELESVEKCSGGSKRSFVLRkGKAKTQRFLnQFHYTKWPDRDVPRNMS------SLLDFISEVRKDHEQNNS--PLF
 || .|||. . .   | .|.|.|  .| || .|  ..   |.  |....| .  |.|..|||. |||.        .||  . .||. ... .   || 
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePll

IHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
.||||||||||.||..| .|   ...| ||.   ....|. |...||. |||.|.|.||.|| 
vHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1317-1556 1.2e-67 222.5 In-house 2-239 (239) alignment 
Range on Protein: 1317-1556
Range on HMM: 2-239/239.0
VAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQ-HPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPET
 |||..|  |||| ||. || ||| |  |..|| ||| |||..  ..  |. |||.||  ..|  |||||.|||  . | |.| | || | ||.||||..
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

STTpllFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVV
..    . .. | |   |  .    |.||. .     .|.. |.|.| |||. ||.  ...| .  .. ||      |  ||||||||||| .. ||...
tsk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

SEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
 .||..| |||| .|  ||. || |||| ||| |.. ||||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1318-1556 1.2e-67 222.6 In-house 2-238 (239) alignment 
Range on Protein: 1318-1556
Range on HMM: 2-238/239.0
AKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQ-HPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETS
|||..|  |||| ||. || ||| |  |..|| ||| |||..  ..  |. |||.||  ..|  |||||.|||  . | |.| | || | ||.||||...
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

TTpllFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVS
.    . .. | |   |  .    |.||. .     .|.. |.|.| |||. ||.  ...| .  .. ||      |  ||||||||||| .. ||... 
sk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

EAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
.||..| |||| .|  ||. || |||| ||| |.. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1324-1556 1.4e-67 222.4 In-house 4-237 (237) alignment 
Range on Protein: 1324-1556
Range on HMM: 4-237/237.0
FEKNRYKNILPYDSSRVQLAILNDDpdSDYFNASFIPSFQ-HPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETStTPLLF
  |||| ||  || ||| |     .  ||| ||... .|.  |..|||.||| ..| ||||.|.|||. . | |.| | |||..|| .|||.|   |  .
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaay

GDITVELESVEKCSGGSKRSFVLR-KGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEV--RKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAK
| .|| |   |. |  . ||..|  ... |  |.. |...| |||| ||.. ..|| |  ..  |  | .. .|  |||||||||||... ||... .||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

RNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
 .|.|||. .|  | . || ..|||.|| |.....||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1602-1835 3.8e-67 221.4 In-house 28-263 (315) alignment 
Range on Protein: 1602-1835
Range on HMM: 28-263/315.0
CPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNHG--RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-
 |||...  | . . .| .| ||.| ||   .||.|  . ..  ||.||||.... .     |.. .| . .| ||| |.|....|.|.|... .. || 
lpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdki

SCARYWFD--NGMATFGYLSVLTLATTQREGFIQRTLeVSRGDKVRHVVEQYQFLDWPVDVIKQKKSarSLLKLIEEMREVySTQNESPLVVHCLNGVGR
.|..|| |     . || ..| .| . .  . ..| | | |  .  . | |.|| .||   .... |  |||||| |..     ..| .|.|||. ||||
kcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGr

TAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
| |.... |...|| ... |.||..||..|..|...||||
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1282-1561 1.1e-65 216.4 In-house 2-286 (290) alignment 
Range on Protein: 1282-1561
Range on HMM: 2-286/290.0
IPLSDFPAFVQKNR--HSTFFQEEFNDLPEAN-IYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPD--SDYFNASFIPSFQHPRRYIASQGPNK
||...|  ||....    . |...|. |  ..  .  ||.  . | ..||..||..||  |. |  .....|   .| ||..|  ... ..||| ||| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPllFGDITVELESVEKCSGGSKRSFVLRKGKA-KTQRFLNQFHYTKWPDRD-VPRNMS
  . |||..||||.|. | |.||  | .| ||.||||...|.   .| ....| . |....  .| . ... .. .... . |.. | |.. . |. . .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

SLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
.|| .   ... . . | .. .|||..|||..|.....  .  .| .  .|.|  . . |. .|..|||..||..... ||.|| | 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_PTPN23_pd Subfamily PTPN23 1311-1557 2.7e-65 215.0 In-house 31-279 (288) alignment 
Range on Protein: 1311-1557
Range on HMM: 31-279/288.0
NIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAilndDPDSDYFNASFIPSFQH-PRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCR
.   ...|  ... ||||...|||||..||.|     .   || ||||. .       .||.|.| . .. |||.|.... . .| |... .| .| |. 
earkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

QYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDH----EQNNSPLFIHCSAGVGRT
.||||    .  |||..| |.||.. .  ..| . |.  .|.. . .   ..|.||.  ||   ..||.|. ||.. .    .. . || .|||||||||
rYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRt

GVLITIDSVVSEA-KRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
||.  . ..| |  |.| |.||   ||..|. | .|||.|||.||.||||||.
gvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1282-1564 1.4e-63 209.6 In-house 2-284 (287) alignment 
Range on Protein: 1282-1564
Range on HMM: 2-284/287.0
IPLSDFPAFVQKNR--HSTFFQEEFNDLPEANIYPQ--TVAKKQINFEKNRYKNILPYDSSRVQLAilndDPDSDYFNASFIPSFQHPRRYIASQGPNKA
||.. |  ||.|..   .. |.. |  | . .  ..  |..  . | .|||...||..|  || |     . . || ||.|| .... ...|....|   
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTtpLLFGDITVELESVEKCSGGSKRSFVLR-KGKAKTQRFLNQFHYTKWPDRD-VPRNMSS
 . .||..|...|| .| |.... | .. .| |||||...  ...|. ..|| . |. .|  .| . .. |.||.... ..|...|.|...  |..  ..
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTA
|| .   ..... . |... .|||..|||..... ..  . ..|..  .|.|  . . |. .|..||| |||||....||||| | .| 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0051299 (Phosphotyrosine protein) phosphatases II 1562-1835 2.4e-61 203.0 In-house 2-272 (288) alignment 
Range on Protein: 1562-1835
Range on HMM: 2-272/288.0
NTAIPVNYFTSRLARLQdidrnsKGRRTGMSVQFESIKILCPDPPasmIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRG--NHG
.|.|.|. ..... .|.      ..  ||.  .|| .  |.||..   .. .   ||..| || . ||   .|| |....   .||.||||...|  .  
dteisveellklvlkll......angltglleefeellsllpdlt...lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSR-----GDKVRHVVEQYQFLDW
. | |. |.||||.||| |. ... . |.||..   .. . ||.|| ..|. |.| ..| .| ... .....|||||..     ||.  . | ......|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PvdVIKQKKSARSLLKLIEEMREVYStQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
|        |...||......|.... ....| |||| .|||||..|.... ...|.. |  |.|...||..|. |.. |||.
p..dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 1589-1835 2.1e-60 200.0 In-house 42-285 (308) alignment 
Range on Protein: 1589-1835
Range on HMM: 42-285/308.0
TGMSVQFESIKILCPdppASMIRNGTTAENKPKSRYGNSLPSRVNRVMLrsvnTQSSDFINASFVRGN----HGRLITTEMPMPNTVADFWVMILDYQPT
.... .|| .  ..|      .. .   |||.| || . ||   .|| |     ..||.||||.|.|       . | |  |.||||.||| |. ... .
glleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

AIIMLNDDNQRD-KSCARYWFDN---GMATFGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYst
 |.||..  ... . ||.|| ..   |  ..|...| .| .........||||..  ||.  ..| ......||    .   |...||...|..|...  
vIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl..

qNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
 ...| |||| .|||||..|.... ...|.  |  |.||..||..|  |.. |||.
.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_PTPN14_pd Subfamily PTPN14 1297-1558 2.3e-60 199.2 In-house 23-296 (300) alignment 
Range on Protein: 1297-1558
Range on HMM: 23-296/300.0
STFFQeEFNDLPEANIYPQ-TVAKKQINFEKNRYKNILPYDSSRVQLAILNDDpDSDYFNASFIPS--FQHPRRYIASQGPNKASMDDFWRMIWQENVAT
.  |. |.. .|. .   . ..|| . | ||||.|..|||. .||.|.  ... ...| ||| |      . | ||..||| .  . |||.|.|...|. 
gkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IAMVTNLSEGNKIKCRQYWPET--STTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEV---RKDHE
|.|.|.  |. | |. .|.|..  .   . ||   |  . .|. .    ... |.   .| .| .  . || |||..||..... |... ||   |.  .
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

QN------NSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
..      . |. .|||||||||||||. | ...  . |. .||   ....|. |  .|||  ||||||.....||
seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_CG7180_pd Subfamily CG7180 1292-1562 3.5e-60 198.1 In-house 10-294 (296) alignment 
Range on Protein: 1292-1562
Range on HMM: 10-294/296.0
Q-KNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQEN
. ....   .. |..  |. .|     . .. | ||||. ...|||  || |  |. . .||| ||... || ... ||  ..| | ..|.|||....|.
dkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

VATIAMVTNLSEGNKiKCRQYWPETSttPLLFGDITVELESVEKCSGGSKRSFVLRKG----------KAKTQRFLNQFHYTKWPD-RDVPRNMSSLLDF
. .. ..|.  . .| .. .|||..|     .|.| ||. .... .   .| | | |               .| . .|..|.|.    ||   ..|...
isavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnaliel

ISEVRKDHEQN-----NSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSEN
.  ||.  |..     ..|. ...| |..|.|| ..||  .  ..... ||.|..| ..|.|||..|...|.||..|. .||..| . 
rrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1300-1565 8.5e-59 193.8 In-house 11-273 (283) alignment 
Range on Protein: 1300-1565
Range on HMM: 11-273/283.0
FQEEFNDLPEANiYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDdpdsDYFNASFIP---SFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAM
|.| .. |   .  . ..|  . | .|||...|.|.|  ||.|  ..     || ||.|||   | .. ..||..|.| .  . |||.|...|....| |
frevlkrlsvpd.ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

VTNLSEGNKIKCRQYWPETSTTPllFGDITVELESVEKCSGGSKRSFVLRKG-KAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLF
.|.| |...||| ||||.  .    .|. || |.        ... ..||.   ||.. .|  . .  | . .    . ||. |   . .  |....|. 
ltklqedlrikCsqyWPkrGsed..yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPiv

IHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAI
.|||.|.|||.|.|.. . | .|. . .||.|  |  .|. |. .|||..|||.|.|.|||  |  .| |
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
DSPc_SM00195 1609-1835 1.4e-58 193.7 In-house 17-248 (263) alignment 
Range on Protein: 1609-1835
Range on HMM: 17-248/263.0
MIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQ-RDKSCARYWF
 ....   .|| | || | ||   .|| | . .. ..||.|||....|  .  . | | .|.|.||.||| |... . . |.||.....   . |.||| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DN--GMATFGYLSVLTLATTQRE-GFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDviKQKKSARSLLKLIEEMREVYSTQnESPLVVHCLNGVGRTAVFC
..  |  |||..|| .  .....  .|.||||..  . .  . |.|||. .||    .  .|..|.|.|...... .||. ..|.|||| .|||||..|.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfv

TVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
|.  ..|.. .|..|..|..||..|. |.. |||.
tidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 1609-1835 1.4e-58 193.7 In-house 17-248 (263) alignment 
Range on Protein: 1609-1835
Range on HMM: 17-248/263.0
MIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQ-RDKSCARYWF
 ....   .|| | || | ||   .|| | . .. ..||.|||....|  .  . | | .|.|.||.||| |... . . |.||.....   . |.||| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DN--GMATFGYLSVLTLATTQRE-GFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDviKQKKSARSLLKLIEEMREVYSTQnESPLVVHCLNGVGRTAVFC
..  |  |||..|| .  .....  .|.||||..  . .  . |.|||. .||    .  .|..|.|.|...... .||. ..|.|||| .|||||..|.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfv

TVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
|.  ..|.. .|..|..|..||..|. |.. |||.
tidiilskleeekkvdifeivkelRkqRpgmvqtl
0046845 (Phosphotyrosine protein) phosphatases II 1610-1835 1.8e-58 193.5 In-house 20-260 (284) alignment 
Range on Protein: 1610-1835
Range on HMM: 20-260/284.0
IRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT--QSSDFINASFVRGN-------HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SC
.. .   ||. | || . ||   .|| |.|..   ..||.||||.|.|        . . | | .|.||||.||| |..... . |.||..  ....  |
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

ARYWFDNG-MATFGYLSVLTLATTQREGFIQRTLEVSRG--DKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYST-QNESPLVVHCLNGVGR
|.|| ..| . |.| ..| .| .........||||...   ..  . | ......||    .   |...||......||...   ...| |||| .||||
aqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

TAVFCTVLECISQILDED---DVNVFQTVKMMRNDRMHFVQTE
|..|...  ...|.  |.    |.|...||..|. |...|||.
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_PTPRD_pd Subfamily PTPRD 1608-1835 2.4e-58 193.2 In-house 38-267 (564) alignment 
Range on Protein: 1608-1835
Range on HMM: 38-267/564.0
SMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYW
. ... .  .||.| || | ..   .||.|..|.  ..||.|||||. | .     | |  |...|..||| |. ... . |.||.  . ..|  |..||
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

FDNGMATFGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYsTQNESPLVVHCLNGVGRTAVFCTV
 ..| .|.|.| |   .... . .. ||.....  ..  . |.|..| .||   .   .||.|||.||...|..  .... |.|||| .||||| .|...
PekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv..pesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

LECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
  .. .| .|..|...|.||..|..| . ||||
damlerikeektvDiyqyvkalrkqRnamVqte
subfamily_PTPN1_pd Subfamily PTPN1 1299-1557 2.5e-58 192.1 In-house 7-270 (290) alignment 
Range on Protein: 1299-1557
Range on HMM: 7-270/290.0
FFQEEFNDLP-EANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAilndDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMV
...| ..|.  ||. .|...||.. | ..|||... ||| ||..|     . | || |||..   .  |.|| .|||    .| ||.|.|...  .. |.
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TNLSEGNKIKCRQYWPETST-TPLLFG--DITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDH--EQNNS
 .. | ..||| ||||.      ||.    ..|.| | |. |    | . | . |..  | . .||||.|||  ||.  ...|.|. .||.     ..  
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvG

PLFIHCSAGVGRTGVLITIDSVVSEAKRNK---LVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
|  ||||||.||.| .. .|... . ....    |||   . ..|. |  ..||..| .| | |.|| 
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1292-1571 5.5e-58 191.4 In-house 15-292 (439) alignment 
Range on Protein: 1292-1571
Range on HMM: 15-292/439.0
QKNRHsTFFQEEFNDLPEANIY---PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQ
.||..  .|.|.|. .  ..       ..| .. .  |||||.. ..| .|| |  .   | | |.|| .|  .  .. |||.|||.| . |||||....
dknkq.eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

ENVATIAMVTNLSEGNKikcrqYWPETSTTplLFGDITVELESVEKCSGGSKRSFVL--RKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKD
....|| |.||| |  |     |||  . .   .|||.|  .   .      | | .  .. ... .| . ||||. |||..|| . | .|||.  .   
kktvtivmltnlvesyk.....ywpsdaev..cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa

H-EQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAIPVNYFT
  ...  |. .|||||||||| .|..|  . . | .. ||| | |. .|. | .|||.  || |.|.|||| .   ..|. .. | 
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
0039614 (Phosphotyrosine protein) phosphatases II 1589-1834 9.6e-58 191.3 In-house 32-274 (297) alignment 
Range on Protein: 1589-1834
Range on HMM: 32-274/297.0
TGMSVQFESIKILCPDppasmIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT--QSSDFINASFVRGNHG---RLITTEMPMPNTVADFWVMILDYQP
|..  .||... | ||     .. .   |||.| || . ||   .|| | ...    .||.||||.| | .    . | |  |.|.||.||| |. ... 
tllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

TAIIMLNDDNQRDKSCARYWFDNGMaTFGYLSVLTLATTQREGFIQRTLEVSRgDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYSTQ-NE
|.|.||.. . ... ||.|| ..|  |.| ..| .| .....|...|||||.. ..  . | ..|...||    .   |...||...|..||....  ..
tvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwp..dhgvppslellleflelvrealaelpkg

SPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
 | .||| .|||||..|.. . ...|.  | .|.|...||..|. |.. |||
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1293-1563 1.3e-57 189.8 In-house 10-298 (301) alignment 
Range on Protein: 1293-1563
Range on HMM: 10-298/301.0
KNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILN--DDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQEN
 . ||. |.|....| |..  . ||  .. | . ||.||| .||  |. |.  .  |    .| |||.| .... ...||.||| |  . ||||.|||| 
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

VATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVE------------KCSGGSKRSFVLRKGKAKTQ---RFLNQFHYTKWPDRDVPRNMSS
...| ||||| || | ||.||||.....   || .||.| .              |   ||. ... || | |..   . . |.. |.||.  | |..  
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

LLDFISEV-RKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENT
 |  | .|  . .  . .|. .|||..|.|.|| ....  .  .|..  ||.|. .  .|.|.| .|.| ||| ..|... .||  ..|
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_PTPRN_pd Subfamily PTPRN 1303-1556 3.2e-57 188.5 In-house 34-290 (297) alignment 
Range on Protein: 1303-1556
Range on HMM: 34-290/297.0
EFNDLPEANIY--PQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSfQHPRR--YIASQGPNKASMDDFWRMIWQENVATIAMVT
|.. | . .     ..|||.. | .|||.|..|||| |||.|   ... .||| |||.|   . ||.  |||.|||  ... |||.|.|.. |. | ..|
ewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvvivnlt

NLSEGNKIKCRQYWPETSTTPLLFGDITVELESVeKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHC
.|.| .  .|..|||.. .    . .. .  | .  |     ||| |.  ...  | . |||.  ||...|| .  |||.|   | | .    .|. .||
rleeegvkqckrywpdeGsevyhiyevhlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc

SAGVGRTGVLITIDSVVSEA-KRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLE
|.|.||||| | || |..   |  | .||   . ..|. ||..|.||.|..|.. || |
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0047943 (Phosphotyrosine protein) phosphatases II 1591-1834 4.5e-57 188.9 In-house 14-257 (273) alignment 
Range on Protein: 1591-1834
Range on HMM: 14-257/273.0
MSVQFESIkilCPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLrsvNTQSSDFINASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQPTAIIM
.  .|| .   .. .|   .. .   ||| | || . ||   .|| |   . ..||.||||.|.|     . | |..|.||||.||| |. ... . |.|
lleefell...lslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LNDDNQRDK-SCARYWFDNG---MATFGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYSTQ-NE
|... ....  ||.|| ..|   . |.| ..| .| .........||||... |..  ..| ......||    .   |  |||..||..|.....  ..
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsn

SPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
.| |||| .|||||..|.... ...|.  |  |.|...||..|. |.. |||
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt
0036941 (Phosphotyrosine protein) phosphatases II 1605-1835 1.8e-56 187.0 In-house 26-263 (297) alignment 
Range on Protein: 1605-1835
Range on HMM: 26-263/297.0
PPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLrsvNTQSSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCAR
 .   .. .   ||..| || . ||   .|| |   . ..||.||||.| | .   . | |. |.||||.||| |..... | |.||... ....  ||.
lllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWFDN--GMATFGYLSVLTLATTQ--REGFIQRTLEVSR-GDKVRHVVEQYQFLDWPVDviKQKKSARSLLKLIEEMREVYSTQ-NESPLVVHCLNGVGR
|| ..  .  |.| ..| .| ...   .....|||||.  |..  ..| ......|| .  .   |..|||..||..|.|..   ...| .||| .||||
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdh..gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TAVFCTVLECISQIL---DEDDVNVFQTVKMMRNDRMHFVQTE
...|...  ...|.     |  |.....||..|. |.. |||.
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0040438 (Phosphotyrosine protein) phosphatases II 1606-1835 2.1e-55 183.6 In-house 31-262 (317) alignment 
Range on Protein: 1606-1835
Range on HMM: 31-262/317.0
PASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCAR
. . .. .   |||.| || . ||   .|| | ...   .||.||||.| |     . | |  |.||||.||| |. ... | |.||..  ... . ||.
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaq

YWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPVDVIKQkkSARSLLKLIEEMREVYStQNESPLVVHCLNGVGRTAVFC
|| ...  |.| ..| .| ... .|.. |||||.  ||.  . | ......|| . . .  | ..||...|..||... ....|..||| .|||||..|.
YwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllldfleavreale.dpggpvlVHCsaGvgRtGtfi

TVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
... ...|.  | .|.|...||..|. |.. |||.
aaylmleqlekeggvdveeavkelreqRpgavqtp
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1562-1835 3.6e-55 182.3 In-house 2-276 (298) alignment 
Range on Protein: 1562-1835
Range on HMM: 2-276/298.0
NTAIPVNYFTSRLARLQDIDRNSKgrRTGMSVQFESIKILCPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGNHGR-
|| | .. ..  | .|...... |   ||.. .|. ..    . ..   . . . ||| | || . ...   ||.|....  . ||.|||||. . .|| 
nteieaedlkaalqklaavkkkkk..ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

-LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDV
  |.|. |...||.||| |. ... ..|.||.. .. ||  . .|| |.| .|.| ..|  |.. .   .|.|.|.||. . . .. | | .|  ||   
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

IKQKksARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
. ..  |.|.|.|....|   .   ..|..|.| .||||.  |. .   . ..  |  | |||.||..|..|.. ||||
vpen..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
0043336 (Phosphotyrosine protein) phosphatases II 1588-1834 1.5e-54 180.7 In-house 19-262 (278) alignment 
Range on Protein: 1588-1834
Range on HMM: 19-262/278.0
RTGMSVQFESIKILCPdppaSMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQ-SSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPT
.|... .||..    .     ... .   |||.| || . ||   .|| | ...   .||.||||.| |     . | |  |.|.||.||| |. ... |
ktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

AIIMLNDDNQRD-KSCARYWFdNGMATFGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYStQNE
 |.||...  .. . ||.||  .|. |.| ..| .| ... .....|||||.. ||.  . | .|..|.||    .   |  .||......||...  ..
tivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale.dsn

SPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
.|..||| .|||||..|.... ...|. .|  |.....||..|. |.. |||
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqt
Y_phosphatase Protein-tyrosine phosphatase 1618-1834 3.8e-54 178.9 Pfam-A 1-222 (235) alignment 
Range on Protein: 1618-1834
Range on HMM: 1-222/235.0
NKPKSRYGNSLPSRVNRVMLrSVNTQSSDFINASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWF--DNGMATFG
|| | || . ||   .|| | . ....||.|||..|.|  .. ..| |..|...|..||| |..... ..|.||...... .. ||.||   .... |.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

YLSVLTL-ATT-QREGFIQRTLEVSRGDKVR--HVVEQYQFLDWPVDVIKqkKSARSLLKLIEEMREVYsTQNESPLVVHCLNGVGRTAVFCTVLECISQ
 ..| .   .. . .... |.||..  .. .  . |.|... .||   ..  .|..|||.||.....   .....|.|||| .|||||..|...  ...|
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

ILDEDDVNVFQTVKMMRNDRMHFVQT
. .|..|.|.|.||..|. |.. ||.
leaeeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 1618-1834 3.8e-54 178.9 In-house 1-222 (235) alignment 
Range on Protein: 1618-1834
Range on HMM: 1-222/235.0
NKPKSRYGNSLPSRVNRVMLrSVNTQSSDFINASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWF--DNGMATFG
|| | || . ||   .|| | . ....||.|||..|.|  .. ..| |..|...|..||| |..... ..|.||...... .. ||.||   .... |.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

YLSVLTL-ATT-QREGFIQRTLEVSRGDKVR--HVVEQYQFLDWPVDVIKqkKSARSLLKLIEEMREVYsTQNESPLVVHCLNGVGRTAVFCTVLECISQ
 ..| .   .. . .... |.||..  .. .  . |.|... .||   ..  .|..|||.||.....   .....|.|||| .|||||..|...  ...|
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

ILDEDDVNVFQTVKMMRNDRMHFVQT
. .|..|.|.|.||..|. |.. ||.
leaeeevdvlqivkelRkqRpgmvqs
0045450 (Phosphotyrosine protein) phosphatases II 1565-1834 1.7e-53 177.7 In-house 3-289 (307) alignment 
Range on Protein: 1565-1834
Range on HMM: 3-289/307.0
IPVNYFTSRLARLQDIDRNSKGRRTGMSVQFESIKILCPDPpASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT--QSSDFINASFVRG-------
.|.. | ..|  |. . .. .  .||.  .||... .....    .. .   |||.| || . ||   .|| | |..   ..||.||||.||        
lplslfidalkllllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

---NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKS-CARYWFDNGMA-TFGYLSVLTLATTQREGFIQRTLEVSR--GDKVRHVVEQYQ
   .  . | |  |.|.||.||| |. ... |.|.||...  ...  ||.|| |.|   |.| . | .| ... .|.. |||||..  |..  . | ...
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

FLDWPvdVIKQKKSARSLLKLIEEMREVYSTQ-NESPLVVHCLNGVGRTAVFCTVLECISQILDEDD---VNVFQTVKMMRNDRMHFVQT
...||    .  .|  .||..|||.|.....  ...| .|||  |||||..|.. . ...|. .|     |.....||..|. |.. ||.
ytgwp..dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1590-1834 2.9e-53 176.0 In-house 23-268 (305) alignment 
Range on Protein: 1590-1834
Range on HMM: 23-268/305.0
GMSVQFESIKILcpdppASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQS-SDFINASFVRGNHG--RLITTEMPMPNTVADFWVMILDYQPTAI
|. .|..|.  .      ..|  |.. .|| |.|. .  .   .|..|.  ...  ||.||||.| | ..  . |..  |..||||||| .|...... |
gleaqykslyee.....eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

IMLNDDNQ-RDKSCARYWFDNGMA--TFGYLSVLTLATTQREGFIQRTLEVSR--GDKVRHVVEQYQFLDWPVDVIKQKksARSLLKLIEEMREVYSTQN
.|| .  .  .. | .|| ..      || .||    ... ...|.| |..|   .||  ..| |||. ||| . . |.  | |||.||..... .. ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdk

ESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
. ||.||| .||||| ||..|   . ..  |. |.||. .| .|. ||  |||
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1317-1558 7.1e-53 174.3 In-house 32-277 (287) alignment 
Range on Protein: 1317-1558
Range on HMM: 32-277/287.0
VAKKQINFEKNRYKNILPYDSSRVQLAiLNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETs
 |..  . .|||| ..||.| .|| |.  . .  ||| || ...|...  ..||.|||  |.. ||||.......|.....|   |  . || .||||  
aaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.

TTPLLFGDITVELESVEK-CSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHE-----QNNSPLFIHCSAGVGRTGVLIT
  |.. |  .| | . ..     . |.. | . ...  | ..|... .|||. ..    .|. |. .|..  |     ..  || .|...|.||.|.|..
evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
.  .||  .    ||.   | ..|. |  .||.  |....|||.  | 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1576-1834 2.9e-52 172.5 In-house 8-264 (288) alignment 
Range on Protein: 1576-1834
Range on HMM: 8-264/288.0
RLQDIDRNSKGRRTGMSVQFESIKILCPDppaSMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNHGR--LITTEMPMPNTVA
 .. . . |.  |||.| ...|.  |  .   .    |  |.|..| || | ||   .|| |. . .....|.||||.. |....   |.|  |...|| 
pvakvakksarnrtgfseeynsLaalekt...ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

DFWVMILDYQPTAIIMLNDD-NQRDKSCARYWFDNGM-ATFGYLSVLTLATTQREGFIQRTLEVSRGDKvRHVVEQYQFLDWPVDVIkqKKSARSLLKLI
||| .. ... . |.||..  .. .. | .|| |..    .| . |  . . . | |..|.|.. .  . .  . |||.| || . .   .|.. ||.|.
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkt.eleitqyqylaWpdhgv..Peskapllell

EEMrEVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
. . .| ....  |..||| .||||| .| ..   | ..  || ..|. ||. .|. |. .|||
rqv.kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt
0045098 (Phosphotyrosine protein) phosphatases II 1603-1834 1.5e-51 170.8 In-house 18-257 (278) alignment 
Range on Protein: 1603-1834
Range on HMM: 18-257/278.0
PDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMlrsvntqssDFINASFVRGNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCAR
. .. |.| ..   .|..| || . ||   .||          |.||||...| . . | |  |.|.|||||| |. ... |.|.||..  ..  . ||.
llgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSR-----GDKVRHVVEQYQFLDWPVDVIKQKKSARSLLKLIEEMREVYS------------TQNESP
|| ..|. |.| ..| .| ... . .. |||.|        |   . |.....| ||   .      .|.|.|.|..||...             ... |
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

LVVHCLNGVGRTAVFCTVLECISQIldEDDVNVFQTVKMMRNDRMH-FVQT
 .|||  |||||.... .  .....  |. |.....||..|. |..  ||.
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqn
0040439 (Phosphotyrosine protein) phosphatases II 1614-1834 1.5e-51 170.7 In-house 7-231 (249) alignment 
Range on Protein: 1614-1834
Range on HMM: 7-231/249.0
TTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWFDNGMA
   |||.| || . ||   .|| | ...    ||.||||.. |     |.| |  |.|.||.||| |. ... |.|.||... ..  . ||.|| ..|. 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

TFGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYSTQ-NESPLVVHCLNGVGRTAVFCTVLECIS
..| ..| .| ... .....||||... .|.  . | ..|..|||    .  .|  .||..||..|.....  ...|..||| .|||||..|.. . ...
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

QILDEDDVNVFQTVKMMRNDRMHFVQT
|.  | .|.....||..|. |.. ||.
qlekelgvdleeavkllrsqRpgavqn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1591-1835 9.6e-51 167.7 In-house 22-266 (318) alignment 
Range on Protein: 1591-1835
Range on HMM: 22-266/318.0
MSVQFESIKilcPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAII
.| ..| ..   ...  .   . ..  || | || | |.    || |. . ....||.|||... |..     | .  |.|.|. ||| |. . . . |.
lseeyerls...rseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLNDDNQRDK-SCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYSTQNESPL
|| . ..| |  ..||| ..|  ..| | |    ... . .. |...|.| . .   .| ||.. .||   .   .|. |||.|. . ...  .....|.
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv..pesgaslldlvrqvskaqqksgagpi

VVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
||||  ||||| ||..|   . .| .|  |.||||||..|. |   ||||
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte
0042113 (Phosphotyrosine protein) phosphatases II 1615-1834 9.8e-51 167.9 In-house 6-228 (245) alignment 
Range on Protein: 1615-1834
Range on HMM: 6-228/245.0
TAENKPKSRYGNSLPSRVNRVMLRSVNTQS-SDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDNGMAT
  |||.| || . ||   .|| | .....  ||.||||.| |    ...| |  |.|.||.||| |. ... |.|.||...  ...  ||.|| .... |
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

FGYLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQI
.| ..| .| ... .....|||||.. ||.  . | .|..|.||    .   . ..||...|..|....  .. |..|||  |||||..|.... ...|.
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

LDEDDVNVFQTVKMMRNDRMHFVQT
  | .|.....||..|. |.. |||
ekelgvsleeavkelrsqRpgavqt
subfamily_Ptp69D_pd Subfamily Ptp69D 1611-1833 1.1e-49 164.2 In-house 41-270 (307) alignment 
Range on Protein: 1611-1833
Range on HMM: 41-270/307.0
RNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDN
...   ||. | || .  .   .||.|. .|  ..||.|||||..|   . . |.   |. .|. ||| || . . | |.|| . .. ..  ||.|| ..
kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie

GMATFGYLSVLTLATTQREGFIQRTLEVSRGD-K-----VRHVVEQYQFLDWPvDVIkQKKSARSLLKLIEEMREVYSTQnESPLVVHCLNGVGRTAVFC
    .| . | .  . . . .|.|.|.||. . .      .. | ||... |. |..   ..||.||||||..||.|... .||.|||| .||||...| 
devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.Dsk.vPevargllklieqvrelykln.rsPivvhCsaGvgrsgifv

TVLECISQILDEDDVNVFQTVKMMRNDRMHFVQ
..   . |.  || |..|.||| .|..|  .||
aldsllqqlkaedkvdifetvkdLrsqRnllvq
0041856 (Phosphotyrosine protein) phosphatases II 1323-1565 1.9e-49 163.1 In-house 1-178 (182) alignment 
Range on Protein: 1323-1565
Range on HMM: 1-178/182.0
NFEKNRYKNILPYDSSRvqlailnddpDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTnlsegnkikCRQYWPetsttpllf
|..||||..||||| ||          |.|| ||... . ....|.|| ||| . .. ||.||...... || ..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gditvelesvekcsggskrsfvlrkgkAKTQRFLNQFHYTKWPDRDVPRnMSSLLDFISEVRKdheqNNSPLFIHCSAGVGRTGVLITIDSVVSEakrnK
                            . .|   |..|. ||| .||  ...||||| ||..    .. | ..||||||||||.|. .. . .     .
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

lVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENTAI
 |...  |. .|. ||.||.| .|| |.. |.||.||  .| .
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1588-1835 2.7e-49 162.6 In-house 19-269 (290) alignment 
Range on Protein: 1588-1835
Range on HMM: 19-269/290.0
RTGMSVQFESIKIlcpDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQ---SSDFINASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQ
..|.  ||....          .  |.| .||.. |. | ...  ||..|| .. .   . ..|||... |  .. . | |. |..||..||| .| . .
negfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

PTAIIMLNDDNQRDK-SCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRGDK--VRHVVEQYQFLDWPVDVikQKKSARSLLKLIEEMREVYST
 |.|.|| . .. .|  |  || |.. ...|. |.  |  .. ...|.|.|||   ..   .. | |||.  |. .   . .   . | .|||| .    
vtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg..kvtnpqtillvieemyktqrk

QNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
. . ..|||| ..|||.||||..   | .   |  ..||| .| .|  ..  |||.
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv
0051429 (Phosphotyrosine protein) phosphatases II 1350-1564 3.4e-49 163.2 In-house 3-230 (272) alignment 
Range on Protein: 1350-1564
Range on HMM: 3-230/272.0
DSDYFNASFIPSFQH---PRRYIASQGPNKASMDDFWRMiWQENVATIAMVTNLSEGNKIKCRQYWP----------ETSTTPLLFGDITVELESVEKCS
 |.|.||.... . .   |.|...|.|| ... .||||. ..... || ......| .. || .|||          ..|... |.|...| | |.| ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GGSKRSFVLRKG-KAKTQRFLNQFHYTKWPDRDVPRNMssLLDFISEVRKdheqnNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVD--------IF
    | ..|..  .|.. | . ..||| |||. ||..   ||........     . |. .|||||..|||... .. ..    ..  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

GFVSKIRQSRPNMVQTKEQYKFVYEAVLEYlLSENTA
..|...|. ||..||| |||.|.|||.||. | . ..
eaveelraqrpgavqteeqylflyeallel.lrslls
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1615-1835 4.8e-49 161.8 In-house 6-228 (250) alignment 
Range on Protein: 1615-1835
Range on HMM: 6-228/250.0
TAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGNHGR--LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKSCARYWFDNGMATF
  .|| | || . ..    ||.| ...  . ||.|||||. | ..|   |.|  |...|. ||| |.|... ..|.||.. .. .| . .||  ..  ..
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaeky

GYLSVLTLATTQREGFIQRTLEVSRGDKVRH-VVEQYQFLDWPVDVIKQKksARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQIL
| . |  | . .   ...|.| .|.  |  . .| |..|. ||   . ..  |.. |.|.....      ...|..|.| .||||.  |...   . .. 
GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

DEDDVNVFQTVKMMRNDRMHFVQTE
 |  |.||. .|..|.||.| |...
kekvvdvfkvikvlrkdrphavesl
subfamily_PTPRB_pd Subfamily PTPRB 1581-1835 1.6e-48 160.3 In-house 17-271 (293) alignment 
Range on Protein: 1581-1835
Range on HMM: 17-271/293.0
DRNSKGRRTGMSVQFESIKILCPDPPasmIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGNHGR--LITTEMPMPNTVADFWVM
.....   ...| ..|..| .  |     .   ..|.|. | || | ||   .|| | .... ..||.|||....|.. .   |.|  |.|.|| ||| |
kkmkadsdlrfseeyeelkavgkdqa...vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrm

ILDYQPTAIIMLNDDNQRDK-SCARYWFDN-GMATFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHvVEQYQFLDWPVDVIKqkKSARSLLKLIEEMRE
... . ..|.|| .   . |  | .|| ..    ..| ..|  .|... | .. |.|....... |. |.||.|. ||   .   .....||......||
vwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerk.vrqyhftsWpdhgvP..ektktlldfvrtvre

VY-STQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
.  .|....|.||||  ||||| .| .. . ...| .|| |..| .|  .|..|...||||
aiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqte
subfamily_PTPRK_pd Subfamily PTPRK 1616-1835 5.4e-48 158.4 In-house 41-263 (314) alignment 
Range on Protein: 1616-1835
Range on HMM: 41-263/314.0
AENKPKSRYGNSLPSRVNRVMLRSVNTQ-SSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFDNGMAtF
 ||. |.|.|. |.    ||.| ... . |||.|||... . .     | |  |...||.||| ...|.. ..|.||..  .     | .|| ....  .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.y

GYLSVLTLATTQREGFIQRTLEVSR---GDKVRHVVEQYQFLDWPVDviKQKKSARSLLKLIEEMREVySTQNESPLVVHCLNGVGRTAVFCTVLECISQ
| . |  . |.  . ...|.. |..   | . ...| |.||| ||    .  .||..||||. .. .  . ... ..||||..| ||| .|...   .  
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkks.qeeeaGrivvhCsaGaGrtGtfiaidivldm

ILDEDDVNVFQTVKMMRNDRMHFVQTE
|  |. |.||..|| .|. .. .|.||
ieregvvdvfnavktlrsrkvnmvete
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1589-1834 7.1e-47 154.8 In-house 20-263 (287) alignment 
Range on Protein: 1589-1834
Range on HMM: 20-263/287.0
TGMSVQFESIKILCPDPpaSMIRNGTTAENKPKSRYGNSLPSRVNRVMLRsvnTQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAI
.| . ||  .. .  ..    .  . . .||.| |. . |.   .||.|.    .  |.|||.|. |   . . | .| || ||. .|| .| | ..|||
egfknqftvleqvtqre..devthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

IMLNDDNQRD-KSCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRGD--KVRHVVEQYQFLDWPvDVIKQKKSARSLLKlIEEMREVYSTQNES
.|| .... | . | .|| ..   ..|  ..  |  .. .|.|.|.||| . .  . .. |.|||. .|. .  | .. . .||  ||||      . ..
vmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWd.stgkvtepqtillv.ieemyktqrkrgnt

PLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
..|||| ..|||.|.|| .   | .   |  ..||| .| .|  ... |||
sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1610-1834 1.8e-46 153.8 In-house 40-273 (325) alignment 
Range on Protein: 1610-1834
Range on HMM: 40-273/325.0
IRNGTTAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGNHGR--LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKSCARYWFDN
 .  .  ||| | |. | ..   .||.| . .   |||.||||..| . ..  .... .|...|. |.| ..||.. . ...||  .. ...|| || ..
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpke

--GMATFGYLSVLTLATTQREGFIQRTLEVSRGDKV-RHVVEQYQFLDWP-VDVIKQKKSARSLLKLIEEMREVYST--QNESPLVVHCLNGVGRTAVFC
     ||| | |   .  .   ...| |.| . .|     |.|.|.  |. . | |.  .  |.|.|.... |   .  .  .|..||| .||||| || 
mgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfi

TVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
..   . ....|  |..|. || .|.||   |.|
slysalakvieesrvdifgfvkklrkdrpsmvet
0037934 (Phosphotyrosine protein) phosphatases II 1613-1834 1.9e-46 154.0 In-house 5-227 (243) alignment 
Range on Protein: 1613-1834
Range on HMM: 5-227/243.0
GTTAENKPKSRYGNSLPSRVNRVMLrsvntQSSDFINASFVRGNhGRLITTEMPMPNTVAD----FWVMILDYQPTAIIMLNDDN-QRDKSCARYWFdNG
.   ||..| || . ||   .|| |     ..||.|||.....  .||| | .|.|.||.|    || |. ... |.|.||...     . ||.||  ..
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.ge

MaTFGYLSVLTLATTQREGFIQRTLEVSR--GDKVRHVVEQYQFLDWPvdVIKQKKSARSLLKLIEEMREVYST-------QNESPLVVHCLNGVGRTAV
. |.| ..| .| ... .....|||....   |.. . | .|..| ||    .   |  .||....|.||...         ...|..|||  |||||..
v.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FCTVLECISQIldedDVNVFQTVKMMRNDRMH-FVQT
... . .....    .|.....||..|. |..  |||
liaaylmllll....gvdleeavkllreqRpgkavqt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1591-1835 4.4e-46 152.4 In-house 25-269 (319) alignment 
Range on Protein: 1591-1835
Range on HMM: 25-269/319.0
MSVQFESIKILCPDppasMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAII
.  .|. .|.  .|     ... .. |||.| || | |.    ||.| ... ...||.|||||. | .   . | |  |. ||. ||| |. ...   ..
lekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLNDDNQRDK-SCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSR-GDKV-RHVVEQYQFLDWPVDVIKQKksARSLLKLIEEMREVYSTQNESP
||...... |  . .|| .. . ..| | |  .   . |..| | |.. .  ..|    | ..|...|| . . .|  |.|||.|....|.  . ... |
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek..atslldllkrirksrektqsgP

LVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
.|||| .|||||  |...   . ..  |  ..||.||...|  |   ||..
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp
0036282 (Phosphotyrosine protein) phosphatases II 1351-1552 3.9e-45 149.0 In-house 2-164 (174) alignment 
Range on Protein: 1351-1552
Range on HMM: 2-164/174.0
SDYFNASFIPSFQHPRRYIASQGPNKasmddFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPEtsttpllfgditvelesvekcsggskrsfvlrkGKA
|||.|||..  .  ..|.||.||| .     ||.|...... |. |.... | .. || .||||                                  . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

KTQRFLNQFHYTKWPDRDVPRNMSsLLDFISEVRKDHEQ-NNSPLFIHCSAGVGRTGVLITIDSVVSEAKrNKLVDIFGFVSKIRQSRPNMVQTKEQYKF
   |.  |..|. |||. ||     ||.|...|.. ... .. |. .||||||||||.|. .. .    . ..|||.. .| ..|. ||.|||| .||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

VYE
.|.
lyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1315-1557 8.7e-45 147.6 In-house 48-282 (290) alignment 
Range on Protein: 1315-1557
Range on HMM: 48-282/290.0
QTVAKKQINFEKNRYKNILPYDSSRVqlaILNDDPDSDYFNASFIPSFQHPrrYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPE
. .  |. .|.|||||..   | .||   ||.|  | ||  | ..   . .  .| .||. |... |.|||. ||.||.| |. .| |  | || ||.||
rkifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

TSTTPLLFGDITVEL-ESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKdheqNNSPLFIHCSAGVGRTGVLITIDS
..   | ||.|||   |. .| .   |. . .|. ..  .  |. ..   |||. |.    .||  .  .||     . |. .|||||.|||| ...|. 
keGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaiev

VVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
 .      | .|. . |  .|.|| | ||   ||  . |..|..
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPN12_pd Subfamily PTPN12 1612-1835 3.8e-44 145.7 In-house 34-263 (290) alignment 
Range on Protein: 1612-1835
Range on HMM: 34-263/290.0
NGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQS-SDFINASFVRGNHGR--LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDNG
.|.. ||. | || . ||   .||.|.  . .  ||.|||.|..| .|.   | .  |.|.|. ||| || ... . ..|.      .|  |.||| ..|
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

-MA-TFGYLSVLTLATTQRE-GFIQRTLEVSRGdKVRHVVEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYStQNESPLVVHCLNGVGRTAVFCTVL-
 .. .|| ..| . .  . . .|. |||.| .  | ...|.|... .||   .   .|| |||.|||..||. . ....||||||  ||||| . ...  
eeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgv..Pssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidy

--ECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
  | . .   .....||. |  .|..|   |||.
vrellkaekipeeldvfdlvlelrkqraalvqtk
subfamily_PTPN6_pd Subfamily PTPN6 1573-1835 4.1e-44 145.8 In-house 12-283 (306) alignment 
Range on Protein: 1573-1835
Range on HMM: 12-283/306.0
RLARLQDidRNSKGRRTGMSVQFESIKILCPDPpASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQSSDFINASFVR----GNHGRLITTEMPMP
|  .|.    ...  ..|.. .||...           ..|. .||| | || |.||   .||.|.. ... ||.|||....    |.. . |.|.  ..
rvselek..eeeslekagfeeefeelqqeeakk.llsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

NTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWFDNGMA-TFGYLSVLTLATTQREGFIQRTLEVS--RGDKVRHVVEQYQFLDWPVDVIKQKKSAR
.||.||| |... . . |.|.  .. |  . ||||| |. .  ..| .|| ... .. . .| |.| ||  . .|  . | ||.| .||   ......| 
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgav

-SLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCT---VLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
 ..|. ... .|  ..... |.|||| .|.|||  |     .|. |..   . |... ..||..|. |  .||||
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1300-1557 9.3e-44 144.2 In-house 13-268 (281) alignment 
Range on Protein: 1300-1557
Range on HMM: 13-268/281.0
FQEEFNDLPEANI-YPQTVAKKQINFEKNRYKNILPYDSSRVQLAI-LNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMV
|..|| .||        || .. .| .|||| ||   | ||||| . . .   .||  | .| |    | || .|||.| .  |||||||||| ..| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEK-CSGGSKRsfvLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKdheqNNSPLFI
 .. | |. || .|.|  .   | |  ..|. |      |  . |   |        |.. .. . .||| .||     .|  . ..|       .|  |
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr...lnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvi

HCSAGVGRTGVLITIDSVV-SEAKRNKLVDIFGFVSKIRQ-SRPNMVQTKEQYKFVYEAVLEY
||||||||.| |....  . |   .  | ||   ||..|   |   ||| .|| .... .|..
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1610-1834 5.8e-43 142.0 In-house 41-264 (315) alignment 
Range on Protein: 1610-1834
Range on HMM: 41-264/315.0
IRNGTTAENKPKSRYGNSLPSRVNRVML-RSVNTQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKSCA-RYWFD
..     ||| | || | ..    || |    | . ||..||.|. |   . | |... | ...| ||| .. ... . |.||..  ...|. | .|| |
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

NGMaTFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHVVeQYQFLDWPvdVIKQKKSARSLLKLIEEMReVYSTQNESPLVVHCLNGVGRTAVFCTVLEC
. . ..| ..|      . . .  ||| |  ||..|.|| |...  ||   ..  |.. .|..||  .. .. |.. ...|||| .|||||  |.|.   
kkv.iyGkitvtrkseevnteytvrtlsvvfgdnirevv.qlhytswp..dmgvpkytiplmnlirtvk.qhhtnsvgaivvhcsaGvGrtGtfitldav

ISQILDEDDVNVFQTVKMMRNDRMHFVQT
. |.  |. ..|.. .. .|. |.. ||.
ldqaeaenaidvynfitgvrqnrikmvqv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1615-1834 6.5e-43 141.7 In-house 17-249 (270) alignment 
Range on Protein: 1615-1834
Range on HMM: 17-249/270.0
TAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVR---GNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDD-NQRDKSCARYWFDNG--
.| .|   || . ||| . ||.| .... . . .||| .||   |.. . |..  |.|.|. .|| ||.. . |||.|. .  ..  | |.|||  .   
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--MATFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHVVeQYQFLDWPVDVIKQKK----SARSLLKLIEEMREVYSTQNES-PLVVHCLNGVGRTAVFC
    ..| ..||.|.....||.|.. |.. .  . |..|  ... .|| . . ...    |...|||.....|.. . .... ||.||| .||||| .. 
kvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

TVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
..  ..  .  .  |.| . .. .|.||| .||.
alDiavrlLeetkkvdvlaiieelRkdRmalvqh
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1611-1833 7.2e-43 142.1 In-house 54-275 (319) alignment 
Range on Protein: 1611-1833
Range on HMM: 54-275/319.0
RNGTTAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNddnqrDKSCARYWFDNG
      .|| | |..| |.   |.| |. ..  . ||.|||||| |   . . |..  |..||.|||| || .|. ..|..|       . |..||  ..
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplki

MATFGYLSVLTLATTQREGFIQRTLEVSRGD--KVRHVVEQYQFLDWPvDvIKQKKSARSLLKLIEEMREVYSTQ-NESPLVVHCLNGVGRTAVFCTVLE
  . .   |   . .. . .. | .|.|.    |    . |. || || |   . ...  |..|.. .| . | . .. ..||||  ||||| |. ..  
vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwp.d.vGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv

CISQILDEDDVNVFQTVKMMRNDRMHFVQ
 .... .|. |.|...|. .|..| ..||
lldrmkeekqvdvynfvrdlrqqrntlvq
subfamily_PTPRA_pd Subfamily PTPRA 1612-1835 7.4e-43 141.7 In-house 52-281 (330) alignment 
Range on Protein: 1612-1835
Range on HMM: 52-281/330.0
NGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFDNG
  .  ||| |.|. | ||   .||.|  ..  ..||.|||||. | .   . |..  |  .|| ||| || ... ..|.|| . ..|. . ||.|| |.|
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

MATFGYLSVLTLATTQREGFIQRTLEVS-RG----DKVRHVVEQYQFLDWPVDVIKqkKSARSLLKLIEEMREVYSTQNEsPLVVHCLNGVGRTAVFCTV
. |.| . |    .|  . .  | . |   .    .|   .|.|. |  ||   .     .. .|||.......   . . |.||||  |||||  |...
lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP..fepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivl

LECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
   . ..  |  |.||..|| .|. | . |||.
davlervkaerkvdvfefvkrlrlqrpqmvqtd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1300-1560 1.3e-42 140.9 In-house 18-279 (307) alignment 
Range on Protein: 1300-1560
Range on HMM: 18-279/307.0
FQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAIlnDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTN
...||. | . .    ||   . | .||||...   | .|. . .  |   |||  | ..    .|...|..||| .... .|| |. ||.| .. |. .
lvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

LSEGNKIKCRQYWPETSTTPLLFGD----ITVELESVEKCSGGSKRSFV--LRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDheqnNSP
. |  ||||.||||      | ||.    |.|.   ..| .   .   |  |.   |.  | .... ...|||| ||.   . ..... || |    . |
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnp

LFIHCSAGVGRTGVLITIDSVVSEA-KRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
. .||||||||.| ...|  |     .     |.  .| ..|. |.  .||. || ...  .|||.| 
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1300-1557 1.5e-42 140.4 In-house 8-258 (267) alignment 
Range on Protein: 1300-1557
Range on HMM: 8-258/267.0
FQEEFNDLPEANIYPQTVAK--KQINFEKNRYKNILPYDSSRVQLAILNDDpdsdYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMV
...||. . .     .|...   . | |.||. . |||| .|| |   ...    | |||.. ...  . .|. |.| | .. ||. .| ...|..| ..
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TNLSEGNkikCRQYWPETSTTPLLFGDITVElESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNM-SSLLDFIseVRKDHEQNNSPLFI
|.  ..|    |..||        . |.|||  |.||     .   .  | | .. . .  ..| ||      .     |.  .   ... |. | || .
tkvftdn...irlfwPPkmgqakkyqdltve.hslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvv

HCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
.||.||||.| ...||| .  ||..  .||| |. |||. |. .|.|||.| ...| . ||
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1616-1833 1.9e-42 140.7 In-house 23-239 (284) alignment 
Range on Protein: 1616-1833
Range on HMM: 23-239/284.0
AENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNddnqrDKSCARYWFDNGMATFG
 .|| | |.|. |.   |.| |. .   . ||.|||||. |   . . |.|  |..||.|||| || .|. ..|..|      .. |..||  ..  . .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikee

YLSVLTLATTQREGFIQRTLEVSRGD--KVRHVVEQYQFLDWPVDviKQKKSARSLLKLIEEMREVYSTQ-NESPLVVHCLNGVGRTAVFCTVLECISQI
   |   . .. | .. | .|.|.    |    . |. || ||     . ...  |..|.. .| . | . .....||||  ||||| |. ..   ....
rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdv..gvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

LDEDDVNVFQTVKMMRNDRMHFVQ
 .|. |.|...|. .|..| ..||
keekqvdvynfvrdlrqqrntlvq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1588-1834 2.1e-41 136.7 In-house 5-251 (283) alignment 
Range on Protein: 1588-1834
Range on HMM: 5-251/283.0
RTGMSVQFESIKILCPDPPASMIrnGTTAENKPKSRYGNSLPSRVNRVMLRSVNTqssDFINASFVR-----GNHGRLITTEMPMPNTVADFWVMILDYQ
 ... ...| .| |.  .  . |   .. |||.| |. . .|  ..|| |.| .    |.|||.|.       .  . | .  |. .|| ||| |. | .
vnnnklfrevlkrlsvpdldadi..asadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

PTAIIMLND-DNQRDKSCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRG--DKVRHVVEQYQFLDWpvDVIKQKKSARSLLKLiEEMREVYST
 |||.||    .. .. |..||  .|   .| . |     |  . ||.. | .      |   ..  ||. ||    . ..    ||.|. . ..     
itaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkf.nkvislqte

QNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
....|.|||| .|.||||||...   . ..| |  |.||..||.||..||  |||
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1580-1834 2.2e-41 136.8 In-house 6-261 (281) alignment 
Range on Protein: 1580-1834
Range on HMM: 6-261/281.0
IDRNSKGRRTGMSVQFESIKILCPDPPASMirnGTTAENKPKSRYGNSLPSRVNRVML-RSVNTQSSDFINASFVRGNHG--RLITTEMPMPNTVADFWV
....|.   .|.  ..|... .  | .|.     .. ||. | || |       || . .. .....|.|||.|| | .|  . |.|. |.|.....|| 
lkqlsqndnaGfieeyeklaaigvdntata...skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MILDYQPTAIIMLNDDNQRDK-SCARYWFDNG-MATFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHVVEQYQFLDWPVDVIKQkkSARSLLKLIEEMR
|..... .||.|.  . . .|  | ||| |.    ..| . | ..|..... .|.|.....| .     ||| ... ||   . .  ... ||.  .|..
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPa..ttkellefrkevl

EVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILDE-DDVNVFQTVKMMRNDRMHFVQT
.. ..... |||.||  ||||| .. ..   .... .|  ...| ..|. .|..|. .|||
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqt
0049772 (Phosphotyrosine protein) phosphatases II 1315-1559 2.7e-41 137.7 In-house 38-281 (314) alignment 
Range on Protein: 1315-1559
Range on HMM: 38-281/314.0
QTVAKKQINFEKNRYKNILPYDsSRVQLAILNDDpDSDYFNASFIPSFqhpRRYIASQGPNKASMDDF----------WRMI--WQENVATIAM------
 .||..  | .||||..|||.| .||.|  |. . .|||.|||.. .|   ...||.|||..  ..||          |||.  .. || .| |      
ilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------VTNLSEGNKIKCRQYWPETSttpllfgditvelesvekcS-------GgskrsfvlrkgkaktQRFLNQFHYTKWPDRDVPrNMS
                ..|.... . . .....                     .                       .|   ..... .|| ..|   .
adelsrLdaAlgKtpllildgngneptaadlellk...................eelydpelf...............erlgikylripvpDgsap.lle

SLLDFISEVRKDheQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKrnklVDIFGFVSKIRQSRP-----NMVQTKEQYKFVYEAVLEYLL
 ...|.  ...   ....|...||.||.||||...... ...  .    |..   .. .|. ||     ..... ||| |..||.|||| 
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_PTPN9_pd Subfamily PTPN9 1586-1834 6e-41 135.4 In-house 13-275 (297) alignment 
Range on Protein: 1586-1834
Range on HMM: 13-275/297.0
GRRTGMSVQFESIKIlcpDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQ
 .. |.| ... |.     |..  . .  .  |  | || . |     ||.| .|. .. ||.|||.|| |   .  .|.|  |...|| ||| |. . .
kgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

PTAIIMLNDDNQRD-KSCARYWF--DNGMATFGYLSVLTLATTQREGFIQRTLEVS--RGDKVRHVVeQYQFLDWPVDVIkqKKSARSLLKLIEEMREVY
   |.|     .|    |..||   .. .| || ||| .. . ..| . .|.||..  . .. |.|.  .||| ||   .   .|| |||...|..||  
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvt.hfqflsWPdyGv..Pssaaslldvlekvrekq

ST------------QNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
..             .. |.||||  |.|||  |.|.  |.|.. ... |.|..|||..|. | . .||
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
subfamily_PTPRG_pd Subfamily PTPRG 1565-1835 2.3e-40 133.3 In-house 1-273 (563) alignment 
Range on Protein: 1565-1835
Range on HMM: 1-273/563.0
IPVNYFTSRLARLQdidRNSkgrRTGMSVQFESIKILCPDPpASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQSS--DFINASFVRGNH--GRL
.||. |.. .| |     ..    .|.| .||...  . .     .      ||| | || | ...   || |...  . .  |.|||... | .     
vpvkefakhvaslh...adg...digfseefealqsetisk.dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskaf

ITTEMPMPNTVADFWVMILDYQPTAIIMLND-DNQRDKSCARYWFDNGMATFGYLSVLTL-----ATTQREGFIQRTLEVSRGDK--VRHVVEQYQFLDW
|.|  |...|. ||| || . . . |.|. .  ..  . | .||  ..  |.| |.|        |. . . .. . |.. ....    ..| ||.. .|
iatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkW

PvDVIKQKKsarSLLKLIEEMREVYSTQN-ESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
| |.   ..   || .||   .. .....   |.|||| .||||| ... .   . || .|. ||||...|..|  | . ||||
P.dhgvPeh...slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte
0043147 (Phosphotyrosine protein) phosphatases II 1348-1552 2.7e-40 133.3 In-house 2-155 (172) alignment 
Range on Protein: 1348-1552
Range on HMM: 2-155/172.0
DPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLsegnkikcrqywpetsttpllfgditvelesvekcsggskrsfvlRK
|..||| |||...   .|.|.|| |||    ..|||||...... .| ..|.|                                              .
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

GKAKTQRFLNQFHYTKWPDRDVPrNMSSLLDFISEVRK-DHEQNNSPLFIHCSAGVGRTGVLITIDSVVseakrnKLVDIFGFVSKIRQSRPNMVQTKEQ
 . . .|.  |..|. ||| .|| ... ||.|.. ...  ..... |  .||||||||||.|. .. .       . ....  |. .|. ||..||...|
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YKFVYE
|.|.|.
yrflyy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1301-1560 5.9e-40 131.9 In-house 25-289 (305) alignment 
Range on Protein: 1301-1560
Range on HMM: 25-289/305.0
QEEFNDLPEANIYPQTVA-KKQINFEKNRYKNILPYDSSRVQLailNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTN
..||. .   | . .  | |.  . .|||||..   |  ||.|   .     .|  | .. .   |.|.| .| | . .  ||| | .|..| .| |. |
raefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn

LSEGNKIKCRQYWPETSTTPLLFGD----ITVELESVEKCSGGS------KRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKdheq
| |    || .|..      | | .    |.| .|| .. .  .      ... .. .|  ...|  ...|.  |||| ||    ..|... . |     
llekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp....

NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLV-DIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
   |. .|||||.|||| .. .. .. .    . . |    . |||. | | .|| .|| ||.. .|.|.. 
skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
0046846 (Phosphotyrosine protein) phosphatases II 1344-1558 7.2e-40 131.9 In-house 5-173 (176) alignment 
Range on Protein: 1344-1558
Range on HMM: 5-173/176.0
ILNDDPDSDYFNASFIPSFqhprRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLlfgditvelesvekcsggskrsf
.| .|.|.|| ||..| .     |.|| |||   .. ||..|...... .. ..|.. | ...|| .||||  .  .                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

vlrkgkaktqrflnQFHYTKWPDRDVPRNmSSLLDFISEVRKDHEQNnSPLFIHCSAGVGRTGVLITIDSVVSeakrNKLVDIFGFVSKIRQSRP-NMVQ
              |.... ||| .||   . ||... ..|.  ...  |  .|||||.||||.|. .. . .    .| ....  ....|. || ..||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavq

TKEQYKFVYEAVLEYL
| |||.|.||..|..|
tpeQyrflyefellll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1617-1834 2.9e-39 129.8 In-house 27-253 (274) alignment 
Range on Protein: 1617-1834
Range on HMM: 27-253/274.0
ENKPKSRYGNSLPSRVNRVMLRSVNTQS--SDFINASFVRGNHGR---LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDNGMA-
 .. | || . ||    ||.|.| ....  |..||| ...| ...    . |  |.|||||||| ||   . . |.|| . .....  ||.|. |.  . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---TFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHvVEQYQFLDWPVDviKQKKSARSLLKLIEEMREVYSTQNES--PLVVHCLNGVGRTAVFCTVLE
   ..| ... .  ...|...  |.| ..   . |. |  | . |||    |. ..|..||.|..|..|  ...|.   | ||||  |.||| .| ... 
iserygdveikvekiverndysvrklvlkylerers.vkhywytdWPdh..ksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

CISQILDEDDVNVFQTVKMMRNDRMHFVQT
.. |. .|  |.|...|  .| ||   |||
avrqlreeivvdvlkivcnlrldrGGmvqt
0049260 (Phosphotyrosine protein) phosphatases II 1358-1552 6.3e-39 128.4 In-house 1-144 (152) alignment 
Range on Protein: 1358-1552
Range on HMM: 1-144/152.0
FIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWpetsttpllfgditvelesvekcsggskrsfvlrkgkaktqrfln
||. . .|...|| |||   ...|||||... .. || |.|.|.| .|.|| ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVseakrnKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYE
|.... |||  || .   ||...  ..|  .... | ..||||||||||.|. .. .       . |... .|. .|. ||..|....|..|.||
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN13_pd Subfamily PTPN13 1608-1835 2e-38 127.3 In-house 27-255 (273) alignment 
Range on Protein: 1608-1835
Range on HMM: 27-255/273.0
SMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTqssdFINASFVRG----NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARY
   . | ..||| | || | ||    || | .  .    .||||...     .. . | .  |.|.||.||| |. . . . |.|.  . ...|  | ||
dtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WFDNGMAT---FGYLSVLTLATTQREGFIQRTLEVS--RGDKVRHVvEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYStqNESPLVVHCLNGVGRTA
| ..   .    . | |  | .....|| .|.|.|.  .  ..|.|  . .| .||   .   .|| .||... |.|.. .  ...|.||||  |.||. 
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrev.ahlnfvkwPdhgv..Pssaaellqfvaevrrlqt..dagPivvhcsaGiGrsG

VFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
.. |.   .  |  . ...| ..|. .|. |   |||.
tlitidvvlglierdkefdvkeivrklreqrqgvvqtk
subfamily_PTPN3_pd Subfamily PTPN3 1606-1834 3.4e-38 126.2 In-house 29-260 (280) alignment 
Range on Protein: 1606-1834
Range on HMM: 29-260/280.0
PASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTqssDFINASFVRG------NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-S
|   | .   .|| .| || . ||    ||.|.. .|   |.|||..|           | |.|  |...|..||| |. . . . |.|| .  .| .  
pglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CARYWFDNG-MATFGYLSVLTLATTQREGFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDVIKQKKSarSLLKLIEEMREVYSTQnESPLVVHCLNGVGRT
| .|| ...   ..| .||    . ... .. | | ... . | .. . | |.|.||   . ....  ..|...|..|.. |.. |.|.||||  |.|||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsa..dflefvervrklrsgk.eePvvvhCsaGigrt

AVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
 |. ..  ... |  ...|.. . |..||. |. .|||
Gvlilletalalieaaepvypldivrtmrdqramlvqt
subfamily_CG7180_pd Subfamily CG7180 1591-1833 4.1e-38 125.7 In-house 15-274 (296) alignment 
Range on Protein: 1591-1833
Range on HMM: 15-274/296.0
MSVQFESIKILCPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAII
. |... .  | |       . |  .||. | |. . .|   |||.|....  ..||.|||..| .   .   | ||.|. .|| .|| .. | .  |..
frveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MLNDDNQRDKSCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSRG-----------DKVRHVVEQYQFLDWPVDViKQKKSARSLLKLIEEMREV
.| .  .  | .  ||  .... .| . | .. . |   . .||. . .            .    .| ..|.  |...  |   |. .|..|.. .| .
vLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeled.kvPlstnalielrrrvrlw

YSTQ----NESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQ
        .|.|.||.. .|..|. |....  .. ..  |. |.||. ||..|..| . |.
rekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLve
subfamily_PTPN23_pd Subfamily PTPN23 1618-1834 9.4e-38 124.7 In-house 43-265 (288) alignment 
Range on Protein: 1618-1834
Range on HMM: 43-265/288.0
NKPKSRYGNSLPSRVNRVMLRsvnTQSSDFINASFVRGN---HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKS-CARYWFDN-GM-ATF
.  | |. . ||   |||.||    .  |.||||||..       .|.|  |...|..||| |. . .   |.|| . ....|  ..|||  . |   .|
yseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GYLSVLTLATTQREGFIQRTLEVSR--GDKVRHVvEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYSTQ---NESPLVVHCLNGVGRTAVFCTVLECI
| |||    ... | ...|.|...    |.|..|    |.  ||   .   .|  .||....|... |...    . ||||||. ||||| ||. |   .
gdlsvtlksvretethvervlkletldadavksv.shlqltsWpelGv..PasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

SQILDEDD-VNVFQTVKMMRNDRMHFVQT
 ..  ..  ... | |. .|..| . ||.
relekgnglldiiqvvsrlreqRrfmvqe
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1315-1560 1.7e-35 117.5 In-house 34-273 (288) alignment 
Range on Protein: 1315-1560
Range on HMM: 34-273/288.0
QTVAKKQI-NFEKNRYKNILPYDSSRVQLAilnDDPDSdYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWP
. .... | |  ..||.|.   | .||.|    ||||  | .|  ..| ...|| | .| | .. .. .|.|. ...|  | |...| |  | |  .|.|
idiidsfianptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP

ETSTTPLLFGDI-TVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVrkdhEQNNSPLFIHCSAGVGRTGVLITID
        .| . ||  .. .      | | .  . . ... .. . |. .|.|  || |  | | ..  .    .. . |. .|.|||||||| || | 
sklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlilil

SVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
 ..  .. .  . |  ...| |..| . .||. || .|.  |||.|| 
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1605-1834 3.6e-35 116.1 In-house 25-262 (287) alignment 
Range on Protein: 1605-1834
Range on HMM: 25-262/287.0
PPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIML-NDDNQRDKSCAR
  . . .. .   .  | ||.. ||   .||.|     . ||.||| .| .   . . |..  |.. || ||| ..|. . ...|..  . ..  . | .
sstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyk

YWFDN--GMATFGYlSVLTLAT-TQREGFIQRTLEVSRGDKVR-HVVEQYQFLDWPVDVIKQK--KSARSLLKLIEEMREVYSTQNESPLVVHCLNGVGR
|| ..   |   || ||  |    .   .  |.| .   .    .||.|...|.|| .|.       .|  |.  . .    ....  |||||.  |.||
ywPerevPmrvGGy.svvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
. .. ..| ..|. .|   |.| ..|  .|. |  .||.
sGillatlvlvsrledlGrvdvaavvirlreyraalvqa
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1320-1560 4.7e-35 115.7 In-house 52-291 (305) alignment 
Range on Protein: 1320-1560
Range on HMM: 52-291/305.0
KQINFEKNRYKNILPYDSSRVQLAilnDDPDSDYFNASFIPSFQHP-RRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTT
 .|.  ||||...   | | |.|.   . . |||  | ..     | .|.|..|||   ..|.|| |. |..|  | |. .  |  |.|| |||| .   
adiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

PL-LFGDITVELESVEKCSGGSKR--SFVLRKGKAKTQR-FLNQFHYTKWPDRDVPRNMSSLLDFISEVRKdheqNNSPLFIHCSAGVGRTGVLITIDSV
 | | . | ||  |  |           .|.   .  |.  . ....|.|||| ||    . |...| .|      . |. .|||||.|||| ...|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyi

VSEAKRNKLVD-IFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
. .   || .  .  .|  .|. |   .|.  || |..  .|.|.| 
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1721-1835 1.4e-34 114.1 In-house 257-371 (392) alignment 
Range on Protein: 1721-1835
Range on HMM: 257-371/392.0
TTQREGFIQRTLEVSRGDKVRHVVEQYQFLDWPVDVIKQKKSARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQT
|.       . | . |  |  | | ||||  ||     |.. ||||||||  ..    .. |  ..|||| | ||| |||| .|||.|| . | |..|||
tssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqt

VKMMRNDRMHFVQTE
||..| ||| |||||
vkilradrmqfvqte
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1453-1580 4.7e-34 112.4 In-house 88-216 (440) alignment 
Range on Protein: 1453-1580
Range on HMM: 88-216/440.0
QRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQ-NNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVY
 | |.|.||  |||. ||.  . .| .| .| . .|.  |.||..|||||.|||||.|..||.. ||||.  .||| |.. .|..||.|||| ||| ||.
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

EAVLEYLLSENTAIPVNYFTSRLARLQDI
||||| ||. .| |  .  | |. ..|  
eavlegllcgdtliledditerveqiqwp
subfamily_ptpA1_pd Subfamily ptpA1 1301-1511 6.1e-34 112.4 In-house 24-249 (418) alignment 
Range on Protein: 1301-1511
Range on HMM: 24-249/418.0
QEEFNDLPEANIYPQT-VAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSfQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTN
.|||  | |.    .|    |. |  |||| |||| . .||||  ..|   ||| || .|    .|...|..|||   .. |||||.|.. .  | |.. 
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsr

LSEGNKIKCRQYWPETSTT---------PLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKD----
 ||  .||| .||||               .||  .|||  | .       .  .|       | . |..|  |||...|     . ...  . .     
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

--HEQNNSPLFIHCSAGVGRTGVLITI
    . | |. .|||||||||| . | 
ipssdrnvpiivhcsagvgrtgtfcta
PTPc_DSPc_SM00012 1457-1556 9.2e-34 111.2 In-house 3-105 (105) alignment 
Range on Protein: 1457-1556
Range on HMM: 3-105/105.0
NQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNN--SPLFIHCSAGVGRTGVLITIDSVVSEAKRN-KLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEA
...|||.|||  ||....|.|... .|.| .....  .|. .||||||||||.....| ...  ... | |||| .|...|..||.||||.||| |.|.|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

VLE
.||
lle
0044763 (Phosphotyrosine protein) phosphatases II 1334-1558 9.6e-34 111.9 In-house 1-171 (178) alignment 
Range on Protein: 1334-1558
Range on HMM: 1-171/178.0
PYDSSRVQLAILNDDPDSDYFNASFIPsfqhPRRYIASQGPnkasmDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTtpllfgditvelesve
|.| .|| |  | . . |||.|||.|     |. |..|..|      |.......... .| ..|.  |....|| .||||                   
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

kcsggskrsfvlrkgkaktqrflNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEakrnKLvDIFGFVSKI
                        |.... .|| .||  .. .|.|.  ... ......| ..||||||||.|.|. .. . .     .| ...  .. .
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RQSRPnMVQTKEQYKFVYEAVLEYL
|. || .|.. .|....||  |..|
rerRp.ivpnpgqlrqLyefelrll
0051082 (Phosphotyrosine protein) phosphatases II 1349-1555 2.7e-33 110.0 In-house 1-150 (151) alignment 
Range on Protein: 1349-1555
Range on HMM: 1-150/151.0
PDSDYFNASFIPSFqhprrYIASQGPnkasMDDFWRMIWQENVATIAMVTNLSEGNkiKCRQYWPETSttpllfgditvelesvekcsggskrsfvlrkg
| |||.|.|.. ..     ...|.||    ..||......... || ..... | .  .| .|.||..                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

kaktqRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKdheQNNSPLFIHCSAGVGRTGVLITIDSVVSEakrnklVDIFGFVSKIRQSRPNMVQTKEQYK
     . . ..... ||| ..| .  ..|.|......   ..| |...|||||.||||.|. .. .         |...  .. .|..||..||...|. 
.....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FVYEAVL
|.. |.|
fqlfall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1316-1482 3.9e-33 109.6 In-house 26-192 (297) alignment 
Range on Protein: 1316-1482
Range on HMM: 26-192/297.0
TVAKKQINFEKNRYKNILPYDSSRVQLaiLNDDPDSDYFNASFI--PSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWP
..||..  . ||||..|| .|..||.|  |.  ...|| || ..  |  ... .|| .||| .|..||||.......| .|.||..| |. . ||  |||
ssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

ETSTTPLLFGDITVELESveKCSGGSKRSFV--LRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISE
..    |  ||. ||  |  . |   .| ..  |.    . .| ..   .  |||  || ..  |  | ..
svvqerlkagdvvvefls..stsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1323-1577 4.9e-33 109.2 In-house 50-299 (301) alignment 
Range on Protein: 1323-1577
Range on HMM: 50-299/301.0
NFEKNRYKNIlPYDSSRVqLAILNDDpDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLF
. .|.||... | . |   . ...|        | .||.  ||.|.||.||| |....||| |. | .| .|.|...  | .. ||..| | . .  |  
pkdkhryptv.PckPsta.vevivdG.krvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GDITVELESVEKCSGG--SKRSFVLRKGKAK-TQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKdheqNNSPLFIHCSAGVGRTGVLITIDSVVSEAK
|  ...... |.      |||.. ..    | . | .  . |..|.||.||.    | |..  |.|     . |. .|||||.||.  .|. . . .| .
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareve

RNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLeYLLSENTAIPVNYFTSRLARL
 .. ...   . ..|. | | |||..|  ..    . | |. .  . .. ....|| .
adptieltealkhlrehrwngvqtnsqlywmtlGtv.yrlikeygfdmkiyeeqlamf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1710-1835 5.4e-33 108.9 In-house 141-262 (515) alignment 
Range on Protein: 1710-1835
Range on HMM: 141-262/515.0
TFGYLSVLTLATTQREGFIQRTLEVSRGDKvRHVVEQYQFLDWPVDVIKQKksARSLLKLIEEMREVYSTQNeSPLVVHCLNGVGRTAVFCTVLECISQI
 ||...| ....    | |.|.|.| .||.  . | |..| .||   ....  ..|||||| |..   .  .  ||..||. ||||| |.... ......
kfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvaha

LDEDDVNVFQTVKMMRNDRMHFVQTE
 . . |.||..|. .|..|...|||.
kttrmvdvfnfvtnirqkrpylvqtq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1612-1834 1.7e-32 107.4 In-house 34-278 (301) alignment 
Range on Protein: 1612-1834
Range on HMM: 34-278/301.0
NGTTAENKPKSRYGNSLPSRVNRVMLRSVN---TQSSDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWFD
 |.. |||. .|. |  .   ||..|.  .   ... ..||||.. |   . . | .. || .|..||| .|....|..|.|. . ...  ..| .|| .
vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpn

NGMATFGYLSV--LTLATTQR-----------------EGFIQRTLEVSRgDKVRHVVEQYQFLDWPVDVIKqkKSARSLLKLIEEMREVYSTQNESPLV
  . .  .  .  .   ..                   .|.|.|...|.. ||  . | |.|  ||| | .   .  |  |. |...       . .|.|
seaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvks.dksswdvlqlqvtdWpqdGvv..reprtvLqviddvihrqqkigggpvv

VHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
||| ..|.|. |.|.|   . |   |  |.||| .| .|  ..  |.|
VHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1318-1562 2.6e-32 106.9 In-house 30-274 (285) alignment 
Range on Protein: 1318-1562
Range on HMM: 30-274/285.0
AKKQINFEKNRYKNILPYDSSRVQLAilndDPDSDYFNASFIPSF-QHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETS
.  . | . ||| ..   . .|| |     . | ||  ||..    .    ||..|||   .. |||.||.||..| . |.  | ||   ||  |.||  
tayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

TTPLLFGDITVELES--VEKCSGGSKRSFVLRKGKAKT--QRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHeQNNSPLFIHCSAGVGRTGVLITID
   . ||   . |     |  .|    .. . . .  .    ..|. .   |||.  | .   ....   |.|    .. |. .|||||||||  .. ||
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpicvhcsagvgrtatfvgid

SVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSEN
        |  ....  | ..|  | . ||.. |. |.|  ..||.. | 
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg
subfamily_PTPN14_pd Subfamily PTPN14 1608-1834 5.2e-31 102.8 In-house 39-281 (300) alignment 
Range on Protein: 1608-1834
Range on HMM: 39-281/300.0
SMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTQSSDFINASFVR----GNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDD-NQRDKSCARY
...  ..  ||..|.|. . ||   ||| | . . .|...|||| ..    |..   |..  |...|| ||| |. . . . |.|| .. ..  . . .|
allstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WFDN----GMATFGYLSVLTLATTQREGFIQRTLEVSR--GDKVRHvVEQYQFLDWPVDVIK-QKKSARSLLKLIEEMREVYSTQN-----ESPLVVHCL
. ..      ..||   | |  ... . .| ..|..      . |  |   |. ||| . .    |.  | |. .. .|.  ....     . |..|||.
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeert.vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

NGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
.||||| |  ..   |. .  ...... ......|. ||..|||
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt
subfamily_PTPN1_pd Subfamily PTPN1 1611-1834 3.2e-30 99.8 In-house 25-256 (290) alignment 
Range on Protein: 1611-1834
Range on HMM: 25-256/290.0
RNGTTAENKPKSRYGNSLPSRVNRVMLRSVNTqssDFINASFVRGN--HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWF-DN
|.  . ||... || .  |    |..|.. ..   |.||||.|  .  . . | |  |.||||. || |. . .  |..|||   ..    ||.||  ..
reaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

G--MATFG--YLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYST-QNESPLVVHCLNGVGRTAVFC
     ..    |.|  ... ... .. |.||.     .  ... .. .. ||   .   .|  ..||.. ..||  |  ..  | |.||  |.||.  ||
eekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgv..pespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

TVLECISQILDEDD---VNVFQTVKMMRNDRMHFVQT
 |  |. .| ..||   |.. ...  .|. |. ..||
lvdtclvliekkddlssvdikkvllelrkyrlGliqt
0051429 (Phosphotyrosine protein) phosphatases II 1645-1835 1.2e-29 99.2 In-house 4-211 (272) alignment 
Range on Protein: 1645-1835
Range on HMM: 4-211/272.0
SDFINASFVRGNhGR------LITTEMPMPNTVADFWVMiLDYQPTAIIMLNDDNQRDKS-CARYWF------------DNGMATFGYLSVLTLATTQRE
|. |||..| |. ||      |. . .|.|.|.|||| .  ... ..|..| ... |..  | |||             .  . ..|.|.| .| ... .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GFIQRTLEVS---RGDKVrHVVEQYQFLDWPVDVIKQKKsarsLLKLIEEMREvystqnESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVN------
 .| |.|...     ... . | .....||| . . |.     ||.|.|....      . |..|||  |..||.... .| .. .. .|. |.      
dyilrellltlllsagea.revmhlhytdwpdhgvpqea....llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VFQTVKMMRNDRMHFVQTE
  ....|...|  |...||||
lyleeaveelraqrpgavqte
0041856 (Phosphotyrosine protein) phosphatases II 1618-1834 2.2e-29 97.7 In-house 1-156 (182) alignment 
Range on Protein: 1618-1834
Range on HMM: 1-156/182.0
NKPKSRYGNSLPSRVNRvmlrsvntqSSDFINASFVRGNHGR--LITTEMPMPNTVADFWVMILDYQPTAIIMLNddnqrdksCARYWFdngmatfgyls
|..| || . ||   .|          .|.|||....|..     | |  |...|||||. |. ... |.|..|.        . .||            
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp...........

vltlattqregfiqrtlevsrgDKVRHVVEQYQFLDWPVDVIKQkksARSLLKLIEEMREvystqNESPLVVHCLNGVGRTAVFCTVLECISQildedDV
                      ... . . ||..| || . .      ..||..|||..|     .. | .|||  |||||....    ....     .|
......................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

NVFQTVKMMRNDRMHFVQT
.....||..|. |.. |.|
sleeavklvrsrRpgmvit
subfamily_PTPRN_pd Subfamily PTPRN 1591-1834 2.8e-28 93.5 In-house 31-277 (297) alignment 
Range on Protein: 1591-1834
Range on HMM: 31-277/297.0
MSVQFESIKILCPDPPASMIrnGTTAENKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNHGR---LITTEMPMPNTVADFWVMILDYQPTAI
.. ..|...    .| .. .  . . .|  | |. . ||   .|| |..  ....||.||||..  .  |    |.|. |...|||||| |. .   . |
lekewealcayeaepstkev..akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

IMLNDDNQ-RDKSCARYWFDNGMATFGYLSVLTL-ATTQREGFIQRTLEV--SRGDKVRhVVEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYSTqNE
..|   ..   | |.||| |.| ....   |  .      . .. |.. .   . .. |  | |. || ||   .    ||.|||..   .   |     
vnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegv..PasaksllefrrkvnksyrG.rs

SPLVVHCLNGVGRTAVFCTVLECISQILD-EDDVNVFQTVKMMRNDRMHFVQT
.|.|||| .|.||| |.. .   ....|    ....  |.. .|..| ..|.|
cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1301-1561 5e-28 92.4 In-house 29-288 (302) alignment 
Range on Protein: 1301-1561
Range on HMM: 29-288/302.0
QEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDdpdsDYFNASF--IPSFQhpRRYIASQGPNKASM---DDFWRMIWQENVATIA
..||. . .  .  .     . | .||. ...  .|| .|.|.  .|    .| |||   .|...  |  | .| |.. |    ..||||..||..... 
kkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvv

MVTNLSEGNKiKCRQYWPETSTTPLLFGDITVELESVEKCSGGSkRSF---VLRKGKAKTqRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNNS
..    | .|    ...|..| . . .|.. |    ||| ..     .   || .| . .  . |  . | |..  || ....|   . .| . ... ..
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsns.vlanvyvltnWkqkkvpvkyaeliktaakvfakkikade

PLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
.. |    |.|| |...|   .|.. ...| . |   | .||. ||..|.. .|| ..| |.| |.. .
ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1617-1834 1e-27 91.9 In-house 2-224 (237) alignment 
Range on Protein: 1617-1834
Range on HMM: 2-224/237.0
ENKPKSRYGNSLPSRVNRVMLRSVNTQsSDFINASFVRGNHG---RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWFDN-GMATF
||| |.||||      .||.|.   .. ||.|||....|  |   . |... |. ..  ||| |. . . . |.||    .. .. | .|| .    |..
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GYLSVLTLATTQREGFIQRTLEVSRGDKVRH--VVEQYQFLDWPVDVIKQKKSA--RSLLKLIEEMREVystQNESPLVVHCLNGVGRTAVFCTVLECIS
| |.|      .   .  |.| .|.  ....  .. ||||  ||   . |. .|  |   ..|.. . |   .. .| ..||  |||||..|  .   . 
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv...sesgpwiihcsagvgrtgiflvidamlr

QILDEDDVNVFQTVKMMRNDRMHFVQT
|  ..  |.... |. . .|| . .||
qakekkvvdiynyvysieedrpyiiqt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1599-1834 2.4e-27 90.3 In-house 35-268 (290) alignment 
Range on Protein: 1599-1834
Range on HMM: 35-268/290.0
KILCPDPPASMIRNGTTAENK--PKSRYGNSLPSRVNRVMLRsvNTQSSDFINASFVRGNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDD--NQ
. | |  |. ..      .|    | || .     . ||.|.  . .  |.. | .|.| .  .| |. .. .|| |.| |.|. . .||.|| .   . 
eklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedG

RDKsCARYWFDN-G-MATFGYLSVL-TLATTQREGFIQRTLEVSRGDK-VRHVVEQYQFLDWPVDVIKQkkSARSLLKLIEEMREVystqnESPLVVHCL
. | |..|. .. | . ||| ..|| .. ... .  |..|| |   |.   |..  ..   ||   . .  |. .||...  .|..       |.|||| 
kak.ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksval..stlallrtlrilrka.....sGpvvvhcs

NGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
 |.|||  | ..  ..  .||  .... ..|. .|| |.  || 
aGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1311-1561 4.8e-27 89.5 In-house 30-279 (312) alignment 
Range on Protein: 1311-1561
Range on HMM: 30-279/312.0
NIYPQTVAKKQINFE-KNRYKNILPYDSSRVQLAilNDdpDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCR
||....     ..|   ||| ||  .|  |  ||   |  .  |  | |.    .| |....||| . .   ||..      ..| ... . |    || 
nivsdsectaflkfkdlnrypniqcwdrgrftla..gd..enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekca

QYWPETSTTpLLFGDITVELESVEKC--SGGSKRSFVLRK----GKAKTQ-RFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEqnnsPLFIHCSAGV
.|  .  .  . . |  |  |.. .    | ||     |      ||  |   ||.. .. |||  .|    . | ..| |.||.     |.  ||||||
kyisdivgf.vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagv

GRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSE
|||| |. |.|...  .  .  ..      .|. |   |..  || ..  .|||.| |.
grtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_CG42327_pd Subfamily CG42327 1301-1485 6.4e-27 89.0 In-house 8-192 (319) alignment 
Range on Protein: 1301-1485
Range on HMM: 8-192/319.0
QEEFNDLPeaNIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQH-PRRYIASQGPNKASMDDFWRMIWQENVATIAMVTN
 |||.|||  ..  .. .      .|.|. |..|   .|| |    ||. . |..||..  ..  |  |||.| . . |  ||||..|. .  .|  .|.
aeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LSEGNKIKCRQYWPETSTTP--LLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYtKWPDRDVPRNMSSLLDFISEVRK
|||    .| .|.|   | .   |.||| | |   |        ...|.. . .  | |  . | ||.. .|| . ..|.  . |||.
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1660-1834 2.5e-26 87.0 In-house 238-423 (440) alignment 
Range on Protein: 1660-1834
Range on HMM: 238-423/440.0
LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNqrDKSCARYWFDNGM-ATFGYLSVLTLATTQREGFIQRTLEVSRGDKVrHVVEQYQFLDWPVD---
.|.|.||.  || ||| .. ||. ..|||||. |  ||.|. ||  |    ||| ..|    . . .    ||||.   ..| | . |..   ||     
fiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeev.heirqfevqtwptwiqs

--VIKQKKSARSLLKLIEEMREV--Y-STQ-----NESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
  |  |..   ..|.|.. .| .    ||.     .  |..|||| |.  . |||||..|. |. ..  ..||| ....|  |  || |
dgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvpt
0049772 (Phosphotyrosine protein) phosphatases II 1609-1834 4.7e-26 87.7 In-house 37-265 (314) alignment 
Range on Protein: 1609-1834
Range on HMM: 37-265/314.0
MIRNGTTAENKPKSRYGNSLPSRvNRVMLRSVNTQSSDFINASFVRGNhGRLITTEMPMPNTVADF----------WVMIL--DYQPTAIIM-----LND
.|  .   .|. | || . ||   |||.| ... ..||.||||.|.|   . | |. |...|| ||          | |.|  |...  | |     | |
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

DNQR----------------DkscarywfdngmatfGYLSVLTLATTQregfiqrtlevSRG---DKVRHVVEQYQFLDWPVDVIKqkkSARSLLKLIEE
...|                                ..... .|.. .           ..    ... . . .|  ...| .      . . .....| 
elsrLdaAlgKtpllildgng...............neptaadlellk...........eelydpelferlgikylripvpDgsap...lledfdeflef

MREVystQNESPLVVHCLNGVGRTAVFCTVLECISQIldedDVNVFQTVKMMRNDRM-----HFVQT
..|.   ....|..|||  |.|||..|...  ....     .|.. ......|. |.     .|...
ieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieq
subfamily_egg_pd Subfamily egg 1313-1557 6.5e-26 85.7 In-house 30-269 (307) alignment 
Range on Protein: 1313-1557
Range on HMM: 30-269/307.0
YPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNkiKCRQYW
 . | | .. | || | | .   |||||.| . .     |.  |  .        .| .| | | ..||||||..||.|  | |.|   | .  .|  ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyyw

PETSTTPLLF--GDITVELESVEKCSGGSKRSFVLRK-GKAKTQRFLNQFHYtkwpDRDVPRNMSSLLDFISEVRkdheQNNSPLFIHCSAGVGRTGVLI
| . . .| .  | . .|   |.. .    |   |.  |  . .|||. . .    | .   .. | |  .  .|    .   |  ...  || ....|.
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklr....nlskpvvvqdilGvskaatlv

TIDSVVSEAKRNKLV--DIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
.|.  . .  |  ..   .   |  .|. |.  |..  .| |||  || .
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_ptpA1_pd Subfamily ptpA1 1608-1805 7.2e-26 85.9 In-house 37-252 (418) alignment 
Range on Protein: 1608-1805
Range on HMM: 37-252/418.0
SMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVNT-QSSDFINASFVRGNHG-RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYW-
|   .|    |  | || | ||    || |. ..  . ||.||| .. | .  ..| |. |.|||.|||| |. . .   |.||. ...     | ||| 
setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp

----------FDNGMATFGYLSVLTLATTQ--REGFIQRTLEVSRGDKVRHVvEQYQFLDWPVDVIKQ-KKSARSLLKLIEEMRE--VYSTQNESPLVVH
          . ||   ||  ||  .   |      | | . ..   . | .  |||.  ||   | .  .  | ||. | . ..  . |.. . |..||
eqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrdi.tqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CLNGVGRTAVFCTVLEC
|  |||||  ||| .  
csagvgrtgtfctavim
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1618-1834 1.2e-25 85.1 In-house 8-226 (239) alignment 
Range on Protein: 1618-1834
Range on HMM: 8-226/239.0
NKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNHG---RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDD-NQRDKSCARYWFDNgMATFG
|| | || | .    .||.|  . |   ||.||||..|   |     |.|.  .  .  ||| |. . .   |.||    . . | | .|| |.  . . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

YLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPVDVIKQKKSArsLLKLIEEMREvYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILD
 | |    |     .| ||. .|. |.   . | ||.|  ||   . |  .|  .| |  .. .  |     | |.||  |||||  |  .   . |   
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata..vlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EDDVNVFQTVKMMRNDRMHFVQT
.  |..|. || .|.|| |.|||
qktvdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1618-1834 1.2e-25 85.1 In-house 7-225 (239) alignment 
Range on Protein: 1618-1834
Range on HMM: 7-225/239.0
NKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNHG---RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDD-NQRDKSCARYWFDNgMATFG
|| | || | .    .||.|  . |   ||.||||..|   |     |.|.  .  .  ||| |. . .   |.||    . . | | .|| |.  . . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

YLSVLTLATTQREGFIQRTLEVSR-GDKVRHVVEQYQFLDWPVDVIKQKKSArsLLKLIEEMREvYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILD
 | |    |     .| ||. .|. |.   . | ||.|  ||   . |  .|  .| |  .. .  |     | |.||  |||||  |  .   . |   
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata..vlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EDDVNVFQTVKMMRNDRMHFVQT
.  |..|. || .|.|| |.|||
qktvdifnyvkairedrphmvqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1323-1557 7.3e-25 82.1 In-house 52-289 (310) alignment 
Range on Protein: 1323-1557
Range on HMM: 52-289/310.0
NFEKNRYKNILPYDSSRVQLAIlNDDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPlLF
.. |||| ...  |.|||.| | .     ||  | .. .      .| |||| . .. ||||||.||   .| .. . .|  . ||  |||    |   .
ymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte.ty

GDITVE--LES---VEKCSGGskRSFVLRK-----GKAK-TQRFLNQFHYTKWPDRDVPRNMSSLLDfiseVRKDHEQNNSPLFIHCSAGVGRTGVLITI
| | |    ||    | |      .||  .       |.  .  ..  .. .|||| || .    .      |   .    |  .|||||..|..|....
gcirvtnlsesseefeicnla..vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvval

DSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
.  .  ..| . ||.   ......||   .||. || ..    . .
klkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1365-1552 7.4e-25 82.3 In-house 4-198 (199) alignment 
Range on Protein: 1365-1552
Range on HMM: 4-198/199.0
PRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGK--AKTQRFLNQFHYT
 |||||.| | . .| |||.|.|.     | || .    ..     ||| | ..   .| ..|  ...   .  .  ...| .      . | . .. .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

KWPDRDVPrNMSSLLDFI---SEVRKDHEQN-NSPLFIHCSAGVGRTGVLITIDSVVS--EAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYE
 | ..  | |.. .. |.    || | .||. ..|. .||| | | |||....|  |   |  .  .||.|    ..||.|  .. . ..|.|.|.
swkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048076 (Phosphotyrosine protein) phosphatases II 1410-1557 1.2e-24 82.0 In-house 1-142 (145) alignment 
Range on Protein: 1410-1557
Range on HMM: 1-142/145.0
QYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEQNnSPLFIHCSAGVGRTGVLI
.|||   .  | .|.... |.  . .. | .. . |   .    |.  |..|. |||..||  .. ||.|.  ... ....  | ..||||||||||.|.
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

TIDSVVSeakrNKlVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
 .. . .    .. |...  . ..|. ||..|.. .|..|.||..||.
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1366-1552 1.3e-24 81.5 In-house 4-197 (198) alignment 
Range on Protein: 1366-1552
Range on HMM: 4-197/198.0
RRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGK--AKTQRFLNQFHYTK
|||||.| | . .. |||.|.|.     | || .    ..     ||| | ..   .| ..|  ...   .  .  ...| .      . | . .. .| 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDRDVPrNMSSLLDFI---SEVRKDHEQN-NSPLFIHCSAGVGRTGVLITIDSVVS--EAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYE
| ..  | |.. .. |.    || | .||. ..|. .||| | | |||....|  |   |  .  .||.|    ..||.|  .. . ..|.|.|.
wkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0036282 (Phosphotyrosine protein) phosphatases II 1645-1834 1.7e-24 81.8 In-house 2-155 (174) alignment 
Range on Protein: 1645-1834
Range on HMM: 2-155/174.0
SDFINASFVRGNH--GRLITTEMPMPntvadFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFDngmatfgylsvltlattqregfiqrtlevsRGDKVR
||.||||.. ...  .||| .  |..     || |. ... |...||.. ....   | .|| .                              . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HVVEQYQFLDWPVDVIKQKKSarsLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILdEDDVNVFQTVKMMRNDRMHFVQT
. . ||..| || .          ||.......|..|  .. |..|||  |||||....  . .. ..| |. |.....|...|. |.. |||
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
0043147 (Phosphotyrosine protein) phosphatases II 1643-1834 3.3e-24 81.0 In-house 3-146 (172) alignment 
Range on Protein: 1643-1834
Range on HMM: 3-146/172.0
QSSDFINASFVRGNHG--RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDnqrdkscarywfdngmatfgylsvltlattqregfiqrtleVSRGDKV
..||.||||.. ...   |.| |  |..||.|||| |. ... |.|..|..                                          .  ....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

RHVVEQYQFLDWPVDVIKqkkSARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECIsqildeDDVNVFQTVKMMRNDRMHFVQT
 . . ||..| ||        ... ||...| ..|..  ... | .|||  |||||....  . ..       .......|...|. |.. ||.
erlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn
0046846 (Phosphotyrosine protein) phosphatases II 1641-1834 4.8e-24 80.5 In-house 8-158 (176) alignment 
Range on Protein: 1641-1834
Range on HMM: 8-158/176.0
NTQSSDFINASFVRGNhgRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDngMATFGYlsvltlattqregfiqrtlevsrgdk
   ..|.|||... |.  | |.|  |.|.|.|||. |..... ||...|... . .. .|..|| .  . ..|.                          
ldldldyinanlilgs..rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

vrhvveQYQFLDWPVDVIKQKksaRSLLKLIEEMREVYSTQneSPLVVHCLNGVGRTAVFCTVLecisQILDEDDVNVFQTVKMMRNDRM-HFVQT
      ||..|.||   . .    . ||.|.|..||...     | .|||  |.|||....  .     .  | ...|.......|. |. . |||
......qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1591-1834 5.2e-24 79.7 In-house 8-244 (267) alignment 
Range on Protein: 1591-1834
Range on HMM: 8-244/267.0
MSVQFESIKILCPDppASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRsvnTQSSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAIIM
.  .|| || . ..   | |    . .|. . |. ..||   .||.||   |.  ..||||.| | .    .| |. |. ||..||. .| |.. . |..
iekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LNDDNQrDKsCARYWFDN-GMA-TFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHVVEQYQFLDWPVDViKQKKSARSLLKLIEEMRevySTQNESPLV
|    . |.   ..|  . | |  .  |.|      . . .   |||.   ..  | |  | .  | ... ..|   . |. .. . .     . . |||
ltkvft.dn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnint.nnkpylkplfgilaknq...lengnrPlv

VHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
|.| .||||.  | ..   . ..  |. ...|. .. .|. |. .|.|
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1324-1442 1.1e-23 78.5 In-house 48-175 (350) alignment 
Range on Protein: 1324-1442
Range on HMM: 48-175/350.0
FEKNRYKNILPYDSSRVQLA--------ILNDDPDSDYFNASFIPSF-----QHPR-RYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCR
| ||||||||||. |||.|         .      .|| ||...        . |  .||| |.| .  .|||...| . .|  | ..|.. | |  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPETSttpllFGDITVELESVEKCSGGSKRS
.||.| |     . |||| |.|  .  .| . |
rYWqegs.....ydditvklaskwenimginds
0051082 (Phosphotyrosine protein) phosphatases II 1645-1834 5.1e-23 76.8 In-house 3-138 (151) alignment 
Range on Protein: 1645-1834
Range on HMM: 3-138/151.0
SDFINASFVRGNhgrLITTEMPMPntvaDFWVMILDYQPTAIIMLNDDNQRDkSCARYWFDNGmatfgylsvltlattqregfiqrtlevsrgdkvrHVV
||.||.|.| |.   |. . .|..    ||. .. ... ..|..|...  |.  |..|. ..|                                  . |
sdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................iev

EQYQFLDWPVDviKQKKSARSLLKLIEEMREvystQNESPLVVHCLNGVGRTAVFCTVLECISQildeddVNVFQTVKMMRNDRMHFVQT
 ....||||.   .   |  ..|...|....    ... |..|||  |.|||.... .. .. .      |.........|  |...||.
lhipildwpdp..glplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp
PTPc_DSPc_SM00012 1744-1835 3.6e-22 73.9 In-house 2-93 (105) alignment 
Range on Protein: 1744-1835
Range on HMM: 2-93/105.0
VEQYQFLDWPVDviKQK--KsaRSLLKLIEEMREVYSTQN-ESPLVVHCLNGVGRTAVFCTVLECISQILDE-DDVNVFQTVKMMRNDRMHFVQTE
| .|....||    .        |.|.|......... .. ..|.|||| .|||||..|...  ...|. .| . |..||.||..|. |.. ||||
vkhyhytgwpdh..gvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
0048179 (Phosphotyrosine protein) phosphatases II 1451-1552 5.5e-22 73.5 In-house 44-139 (144) alignment 
Range on Protein: 1451-1552
Range on HMM: 44-139/144.0
KTQRFLNQFHYTKWPDRDVPRNMSSLLDFISEVRKDHEqNNSPLFIHCSAGVGRTGVLITIDSVVseakRNKlVDIFGFVSKIRQSRPNMVQTKEQYKFV
   |.  |.... |||..||  .. ||.|.  ... .| .. | ..||||||||||.|.... ..    ... ....  .  .|. ||..|.. .|..|.
fleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

YE
.|
le
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1373-1560 6.2e-22 72.4 In-house 98-290 (302) alignment 
Range on Protein: 1373-1560
Range on HMM: 98-290/302.0
GPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKC--SGGSKRSFVLR-------KGKAKTQRFLNQFHYTK
 | | ... .| .| | ||| .. .... |... || .|. .     | ||  ||.  ||..       |.||.|        | | |... .. .... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDRDVPRNMSSLLDFIsevrKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
|||   |..  . || .    |  |     ...|||||||||| |..|   .   ...|  |.   |  .|| |   ||...|  ..   |   |. 
wpdhGapkeaytaldil....kfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1327-1563 8.8e-22 72.6 In-house 23-264 (290) alignment 
Range on Protein: 1327-1563
Range on HMM: 23-264/290.0
NRYKNILpYDSSRVQLAILNDDPDSDYFNASFIpSFQHPRRYIASQGPNKAS-------MDDFWRMIWQENVATIAMVTNLSEGNKI----KCRQYWPET
.|... |    .|| |        .||. |... .. .  | |..| | ..        . .|| |. ||.|  . |. . .| ..      | .| ||.
qRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

STTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRfLNQFHYTKWPDRDVPRNMSSLLDFISEVRkdheQNNSPLFIHCSAGVGRTGVLITIDSVV
  . | |...||.  | ||  .  .|  |.. .. .    ..   .  | .. |...  .||. |. |.    ....|  .||  |. |  .| .|.   
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeft.vtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

SEAK-RNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENT
      .. | .   ....|. | ......... ||  ... ..  .  
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievld
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1648-1834 1.8e-21 71.2 In-house 83-266 (301) alignment 
Range on Protein: 1648-1834
Range on HMM: 83-266/301.0
INASfvrGNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARYwFDNGMATFGYLSVLTLAT-----TQREGFIQRTLEVS--RGDK
|..|   |.  |.|.|  |..||  |||.|.  |.   |.||    ..  . |. | .   ..    .   .. .       ..  ..|||||    |. 
ipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceey.lpvkisekldigrfkikiknkelilnkkiskrtlevedstgkf

VRHVVEQYQFLDWPVDVIKqkKSARSLLKLIEEMRevystQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
  . |  ||. .|.   .   ||   | .|.| ..     . | |.|||| .|.||.  | .     .... .  ... ...| .|..| . |||
atrtvthyqysewtdrgvP..kshaelfdlmelvk.....ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1587-1833 1.1e-20 68.5 In-house 18-263 (439) alignment 
Range on Protein: 1587-1833
Range on HMM: 18-263/439.0
RRTGMSVQFESIKILCPDPpASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSV-NTQSSDFINASFVRGNHGR--LITTEMPMPNTVADFWVMILDYQP
..  ..  ||.|.   ||  | .    .   ...| || .  .    ||.|. .     | .||| ...| .     |.|..|  .|. ||| .... . 
kqeifkeifekinstspdy.aciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

TAIIMLNDDNQRDKscarYWFDNGMATFGYLSVLTLATTQREGFIQRTLEV----SRGDKVRHVVeQYQFLDWPVDVIKQKKSarSLLKLIEEMREVYST
. |.|| .  .  |    ||  .. . .| ..| .    .   .. | . |     ...| | |. |.... ||   .  . |   .|...  .     .
vtivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvl.qfhyiawpdknvpaqas..hvldflrainsandk

QNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQ
..  |.||||  |||||    ..  .. |.  |. |..   ||..|..| ..||
eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvq
0049260 (Phosphotyrosine protein) phosphatases II 1659-1834 1.1e-20 69.4 In-house 10-135 (152) alignment 
Range on Protein: 1659-1834
Range on HMM: 10-135/152.0
RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWfdngmatfgylsvltlattqregfiqrtlevsrgdkvrhvveQYQFLDWPVDVi
. | |. |.|||.|||| |. ... |.|.||...  ..|  |..|.                                          ||..| || .  
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhg.

kQKKSARSLLKLIEEMREVySTQNESPLVVHCLNGVGRTAVFCTVLECIsqildeDDVNVFQTVKMMRNDRMHFVQT
   ...  || |.. ...    ... | .|||  |||||....  . ..       .|.....|...|. |.. |..
.vpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn
Lectin_C Lectin C-type domain 531-647 2.9e-20 60.4 Pfam-A 2-105 (105) alignment 
Range on Protein: 531-647
Range on HMM: 2-105/105.0
QRTWSDARIHCRDNGGDLAIISSHEQTAFLVTYTSestNGYSYWIGLqDSDGDGQYTWIDDTQPQRTE--SSWapgepNYGDMMDYCACMysenvMDGRH
...| .|.  |. .|..|| |.| |...||  ...   .  ..|||| |.. .|...| |... . .|  . |     .. .  ..|. .      .   
kksweeAekaCqklgahLasieseeelkflskllk...sskkfWigl.dkksegswkwedgsklsteelyknw.....sndgenedCvyl.....resss

GKWNDIWCSNsQKPYICER
|||||  |.. .||.|||.
gkwndesCns.kkpfiCek
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1621-1833 3.8e-20 67.2 In-house 22-243 (290) alignment 
Range on Protein: 1621-1833
Range on HMM: 22-243/290.0
KSRYGNSLPSrVNRVMLRSVNTQ-SSDFINASFVRGNHG-RLITTEMPMPN-------TVADFWVMILDYQPTAIIMLNDDNQRDKS-----CARYWFDN
. |. ..|    .||.|.   .. ..|.| |..|   .| ||| |. |  .       |. .|| |. . . . ..|| . .....      ||.|  ..
dqRlevpLve.atrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

--GMATFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHVVEQYQFLDWPVDVIkqKKSARSLLKLIEEMRevystQNESPLVVHCLNGVGRTAVFCTVLE
  .  .|. |.|      . .....|.|.|  .|.. . |. ... .|    .  ... ..||.||. ..     ....| .||| .|. | |.. ..  
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnv..qedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiil

CISQIL-DEDDVNVFQTVKMMRNDRMHFVQ
    |   ...|.. . .|..|. | . ..
gyQkiaetsgsvkledvlkalrkqralait
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1313-1563 3.4e-19 63.6 In-house 35-284 (303) alignment 
Range on Protein: 1313-1563
Range on HMM: 35-284/303.0
YPQTVAKKQI--NFEKNRYKNILPYDSSRVQLAilnddpDSDYFNASFIpSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQ
 | .|.|.|.  |..|||. ...  | |.|.|.      || |  ||..  ..  .. | .| |   .  |||.|| ...|  . ..   || .|.    
lppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggds

YWPETStTPLLFGDITV---ELESVEKCSGGSKRSFVLRKGKAKTqrFLNQFHYTKWPDRDVPRN-----MSSLLDFISEVRKDhEQNNSPLFIHCSaGV
 .|.     | | . ..   |.  ||   | . .   . .|. |.  ||   || .||  ..| .     .  . .  | .||   ... ....  | |.
vfprnq.dflkfeersirvgefkrvelgdgwvlkvlsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlrky.sdstptvymsls.gc

GRTGVLITIDSV-VSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENT
||.| .  ...  .|  . .  .|.   . ..|. |   ||   |. .||  . |..| .  
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1602-1708 5.6e-19 62.8 In-house 29-147 (392) alignment 
Range on Protein: 1602-1708
Range on HMM: 29-147/392.0
CPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRSVN-TQSSDFINASFVRGNHG--RLITTEMPMPNTVADFWVMILDYQPTAIIMLND-----DN
 |.|...  . . .  |..| ||.| ||   .||.|  .. .  ||..|||.... .     |....| . .. ||| |... ..|.|.|...       
lpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkg

QRDKSCARY----WFDNGM
. ....|..    | |...
ddartvaqfhftewPdkdv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1358-1562 3.6e-18 60.6 In-house 25-225 (255) alignment 
Range on Protein: 1358-1562
Range on HMM: 25-225/255.0
FIPSFQHPRRYIASQgpnkaSMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAKTQRFLN
. |. .. |. . |      ..| |...| | .  ...|.... | .. || .|.|      | . |..|             .  ..  |. |  . ..
vkPekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvk

QFHYTKWPDRDVPRNMSSLLDFISEVRKDheqnnSPLFIHCSAGVGRTGVLITIDSVVS------EAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVY
 ..|. |...  |..   .|  .  ||.       ....|||.|.||.  .. ...|        .      .|   .. ..|..|.  ..|  |  |  
hysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

EAVLEYLLSEN
  ||...  ..
lmvldlvfpkg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1601-1803 4.8e-18 59.8 In-house 20-221 (281) alignment 
Range on Protein: 1601-1803
Range on HMM: 20-221/281.0
LCPDPPASMIRNGTTAENKPKSRYGNSLPSRVNRVMLRS--VNTQSSDFINASFVRGNHG--RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-
|  |||. .        |. | || |     . || |.    | .|.|.| | ..|        | |. |  .| |||| || . . |||.|| .  .  
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn

DKSCARYWFDNGMA--TFGYLSVLTLATTQREGFIQRTLEVSRGDKVRHvVEQYQFLDWPVDviKQKKSARSLLKLIEEMREvystqNESPLVVHCLNGV
 . || |.  |  .   |  |||    .|  . ..   |..|   . |  . .. . .||    .  .|.  .||.. ..|        .| |.||  ||
rekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrl.ithwlwkewpdw..qvpessevmlkilrkira.....rstppvihcsagv

GRTAVFCTVL
||.  . .| 
grsgtlmave
0044763 (Phosphotyrosine protein) phosphatases II 1639-1834 8.3e-18 60.1 In-house 12-156 (178) alignment 
Range on Protein: 1639-1834
Range on HMM: 12-156/178.0
SVNTQSSDFINASFVRGNhgrLITTEMPMpntvADFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFDNGMatfgylsvltlattqregfiqrtlevsrg
  ....||.||||.. ..   |. .  |.    ||.. .. ..  |.|..|...  .   .| .||...                               
leglersdyinaseilpg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.............................

dkvrhvveqYQFLDWPVDVIKQKKSARSLLKLIEEMREVYStQNESPLVVHCLNGVGRTAVFCTVLECISQildedDVNVFQTVKMMRNDRMhFVQT
         .|.| .|..  .   . . .|...| ..|... ....| .|||  ||||.....    ....     ...... ....|. |. .|..
.........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpn
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1489-1558 3.3e-17 57.3 In-house 226-295 (297) alignment 
Range on Protein: 1489-1558
Range on HMM: 226-295/297.0
QNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
  | .|..||||||||.||..  | ...  ..... |.  ..|..|. |. .||| ||....|.|||. |
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 1484-1557 3.8e-17 56.9 In-house 240-314 (319) alignment 
Range on Protein: 1484-1557
Range on HMM: 240-314/319.0
RKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRN-KLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEY
|  ..... || .||| ||||||..|. |  . . . . . |||   || .|. | . |.|||||.|.|  . ||
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1616-1835 4.4e-17 57.1 In-house 41-257 (288) alignment 
Range on Protein: 1616-1835
Range on HMM: 41-257/288.0
AENKPKSRYGNSLPSRVNRVMLRsvntQSSDFIN-ASFVRG--NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKSCARYWFDNGMATFG
 .|  . || |     . || |       .||   |  |    .. ||| .. |.  |.  .| |.|. .   |.||..  .. |  .  .|   .    
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

YLSVLTLATTQREGFIQRTLEVSRGDKVRH-----VVEQYQFLDWPVDVIKQkkSARSLLKLIEEMrevysTQNESPLVVHCLNGVGRTAVFCTVLECIS
 .  |   . ..   |.....||     ..     .| .  .|.|. | . .  .  | |.|.| .      . . |.|||. .|||||. .  .|  . 
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPe..nylsplrllevl.....kslqkPivvhssaGvGrtgtlililiale

QILDEDDVNVFQTVKMMRNDRMHFVQTE
..  .|.. . . .. .|..|.. .|||
slrlddflgirsllaklreerfkaiqte
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1456-1557 6.1e-17 56.4 In-house 217-343 (350) alignment 
Range on Protein: 1456-1557
Range on HMM: 217-343/350.0
LNQFHYTKWPDRDVPRNMSSLLDFIS--------EVRKDHEQ--NNSPLFIHCSAGVGRTGVLITIDSVVSE--------------AKRNKLVD-IFGFV
. |... .|.|  .  |  |.|  .          . . | .  . ||...||||||||||.|.|.||..|.               . .|. | |.  |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SKIRQSRPNMVQTKEQYKFVYEAVLEY
 ..|. | .|||...|. |.|||.| |
nelrkqrismvqnldqfifiYeallfy
subfamily_hpo-7_pd Subfamily hpo-7 1377-1563 1e-16 55.6 In-house 45-232 (263) alignment 
Range on Protein: 1377-1563
Range on HMM: 45-232/263.0
ASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPETSTTPLLFGDITVELESVEKCSGGSKRSFVLRKG-KAKTQRFlNQFHYTKWPDRDVPRNMSS
  .| |...| | .  ...|...  | .. || .|.|      . . ...|    | .      . ..   | | ||. . ... |. |...  |... .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtv.khysykgWiekndpelare

LLDFISEVRKDheqnnSPLFIHCSAGVGRTGVLITIDSVVS------EAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENT
 |  .  .|.       .|..|||.|.||.     ...|        .      .|   .. ..|.||.  ..|  |  |    ||...| ...
ilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1599-1835 1.4e-16 55.4 In-house 23-263 (307) alignment 
Range on Protein: 1599-1835
Range on HMM: 23-263/307.0
KILCPDPPASMIRNGTtAENKPKSRYGNSLPSRVNRVMLRsVNTQSSDFINASFVR--GNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD
..|.   | ..  .     |  | || .      .|.... ..  .||.| | ..    .  ..| .. |. ||. .|| |... .  ..||| .  .  
rvlakktpegvtveaf.santdknryqdvkcqdkgrivvk.fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviela

K-SCARYWFDNGM--ATFGY----LSVLTLAT---TQREGFIQ-RTLEVSRGDKVRHvVEQYQFLDWPVDVIKQKKsaRSLLKLIEEMRevystQNESPL
|  | .||  .     .||     .||  | .   .  | .|.  ||.|  ..| |  ....|. .||   . | .   . . |.| .|      .. |.
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrt.iqhlqwenwpdrgvpqin..ltainlleavr.....ydtnpv

VVHCLNGVGRTAVFCTVLECISQILDEDDV-NVFQTVKMMRNDRMHFVQTE
||||  ||||.    ..     ....  .  .. . |. .|..| . .|||
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqte
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1622-1834 1.8e-16 55.0 In-house 39-255 (285) alignment 
Range on Protein: 1622-1834
Range on HMM: 39-255/285.0
SRYGNSLPSRVNRVMLRSvntQSSDFINASFVRG---NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQ-RDKSCARYWFDN--GMATFGYLS
 || .       ||.|.    .  |.| ||..|    ..   |||. |.|.|..||| || . . . ..||    .   . || |. ..   .  ||   
nryadvrcieetrvvlkn...hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye

VlTLATTQRE---GFIQRTLEVSRGDKVRH---VVEQYQFLDWPVDVIkqKKSARSLLKLIEEMREVYStqNESPLVVHCLNGVGRTAVFCTVLECISQI
. ||.  . |   | |  .| |   .        ... |   || ..    . || ...| . ...|    .| |..|||  |||||| |  .  .  .|
i.tlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla..pedarpmielykwvkkvnp..kekpicvhcsagvgrtatfvgidyatiri

LDEDDVNVFQTVKMMRNDRMHFVQT
... ...... |. ||  |.. ||.
menpniemldivremramrfqavqs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1279-1361 3.8e-15 50.2 In-house 3-85 (440) alignment 
Range on Protein: 1279-1361
Range on HMM: 3-85/440.0
RQPIPLSDFPAFVQKNRHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNASFIPS
..|| ..||  .||.|| |  |..|.. || .   |  .|    |  ||||.||| || ||| |  ..  ||||| |||.| .
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1658-1828 7e-15 49.7 In-house 5-183 (199) alignment 
Range on Protein: 1658-1828
Range on HMM: 5-183/199.0
GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWF--DNGMATFGYLSVLTLATTQREGFIQRTLEVSRGD---KVRHVVEQYQFLD
 | |.|. |. .|.|||| |. .     |.|.|||..  .   . ||   ..| . .| ||| | . | .  .   .| ..           . .|||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPVDVIKQKKSARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECIsQILDED---DVNVFQTVKMMRNDR
|      .      ..    |.   |  ....|..||| .| | | || ..   . .  .|     |..|.  | .|. |
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqar
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1658-1828 7.5e-15 49.6 In-house 4-182 (198) alignment 
Range on Protein: 1658-1828
Range on HMM: 4-182/198.0
GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWF--DNGMATFGYLSVLTLATTQREGFIQRTLEVSRGD---KVRHVVEQYQFLD
 | |.|. |. .|.|||| |. .     |.|.|||..  .   . ||   ..| . .| ||| | . | .  .   .| ..           . .|||  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPVDVIKQKKSARSLLKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECIsQILDED---DVNVFQTVKMMRNDR
|      .      ..    |.   |  ....|..||| .| | | || ..   . .  .|     |..|.  | .|. |
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqar
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1495-1558 1.4e-14 48.2 In-house 2-65 (69) alignment 
Range on Protein: 1495-1558
Range on HMM: 2-65/69.0
FIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
 .|||.| |||| .|.|   ..  | .||||||  |  .|. || ||  . .| |...|. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1496-1558 1.7e-14 47.9 In-house 2-64 (69) alignment 
Range on Protein: 1496-1558
Range on HMM: 2-64/69.0
IHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYL
.|||.| |||| .|.|   ..  | .||||||  |  .|. || ||  ...| |...|. | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
Lectin_C Lectin C-type domain 650-744 1.9e-14 41.6 Pfam-A 3-96 (105) alignment 
Range on Protein: 650-744
Range on HMM: 3-96/105.0
ASYFDAMEYCQQFGGSLAQLKTSEIDLNLTNSF-SSVEFWFGLdSLGKEGVFHWADGTFLRYSRF-TMWksdkpNNYQGYQFCVAR---LIDGWNDQFCN
 |. .| ..||. |..||.....|    |..   || .|| || .  .|| ..| ||. |..... . |     .|... ..||.      ..|||. ||
ksweeAekaCqklgahLasieseeelkflskllksskkfWigl.dkksegswkwedgsklsteelyknw.....sndgenedCvylresssgkwndesCn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1323-1417 5.5e-14 46.2 In-house 48-158 (349) alignment 
Range on Protein: 1323-1417
Range on HMM: 48-158/349.0
NFEKNRYKNILPYDSSRVQLAILNDDPD--------------SDYFNASFI--PSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKI
 | |||||.||||. |||.|      .                || || ..  . ..  ..||| | |  ...|||...|  ..|  .  ...  | .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCRQYWPETST
|| .|| | | 
kcdiywqelsy
subfamily_egg_pd Subfamily egg 1615-1833 5.7e-14 46.5 In-house 37-254 (307) alignment 
Range on Protein: 1615-1833
Range on HMM: 37-254/307.0
TAENKPKSRYGNSLPSRVNRVMLRSVNTQ-SSDFINASFVRGNH--GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRdKSCARYWF--DNGMA
...|. |.|        . || |.  . | . ||| |  |.|.     .| .. |. ||| ||| |.   .   |.||.   .  . |  ||   ..  .
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdsl

TF--GYLSVLTLATTQREG--FIQRTLEVSRGDKVRHVVEQYQfldwpVDViKQKKSARSLLKLIEEMREVystqnESPLVVHCLNGVGRTAVFCTVLEC
 .  | | . .|   ..    |    | .  ||.    .| .|      || ..     | |...  .|..       | ||.. .|| ..|.. ..   
vtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.....gdv.nnssdvysplrvlrklrnl.....skpvvvqdilGvskaatlvaieia

ISQILDE--DDVNVFQTVKMMRNDRMHFVQ
. ..|        | ..|...|  |   |.
llsllrGpitkslvlravvflrlrrrlsve
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1620-1834 6.3e-14 46.5 In-house 35-280 (297) alignment 
Range on Protein: 1620-1834
Range on HMM: 35-280/297.0
PKSRYGNSLPSRVNRVMLRSVNTQsSDFINASFVRG----NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLND--DNQRDKsCARYWF--DNGMATF
 | || . |    .|| |. | |. .|.||| .|      .  . | .. |. .|| ||| .. . .  .|.|.    .. ||| || ||   ...  . 
rknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk.capywpsvvqerlka

GYLSVLTLATTQREgFI---QRTLEVSRGDKVRHvVEQYQFLDWPVDVIK--------QK-------KSARSLLKLIE-----EMREVYSTQNES----P
| . |  |..|  | |       |..   .. |. |   ||| ||   .          .        .   .| |.|      . .. | . |     .
gdvvveflsstsde.fdrviltelqliyrsesrv.vrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnay

LVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
|.|||  ||||. |       ....  .   .|   ....|. |   |||
llvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1457-1558 7.6e-14 45.8 In-house 221-344 (349) alignment 
Range on Protein: 1457-1558
Range on HMM: 221-344/349.0
NQFHYTKWPDRDVPRNMSSLLDFISeVRKD-----------HEQNNSPLFIHCSAGVGRTGVLITIDSVVS--EAKR---NK------LVD-IFGFVSKI
 |. .  |.|  .  |  |.|  .  |..|           .... |.|..||||| ||||||.|.|...|  |  .   ||      | | |.  | ..
lqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnel

RQSRPNMVQTKEQYKFVYEAVLEYL
|. | .|||   |. ..|||.|.|.
rkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1615-1834 1.2e-13 45.5 In-house 45-272 (305) alignment 
Range on Protein: 1615-1834
Range on HMM: 45-272/305.0
TAENKPKSRYGNSLPSRVNRVMLRSvnTQSSDFINASFVR--GNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLND-DNQRDKSCARYWFDNGMATF
 |... | || .      ||| |..  .   ..| | .|    |  |.| |. |. .| |||| | |. .  ||.|| .  ..  | |. |.  .   ..
eaqeagknrykdvgcldnnrvkleg..pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

G-----------YLSVLTLA-TTQREGFIQRTLEVSRGD-KVRHVVEQYQFLDWPVDVIKQkkSARSLLKLIEEMREvystqNESPLVVHCLNGVGRTAV
            . |  ||  ... .  ...|  |  |  .  . | .| . |||   .    .  ..|.|.|. |         |.||||  |.|||  
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarp.....skgpivvhcsagigrtgs

FCTVLECISQILDEDDVNVFQ-TVKMMRNDRMHFVQT
   .   . |.|  . ..  .  .. .|..|   .||
vvmleyildqllagqiiedtdkilqkireqrnnsiqt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1640-1833 1.3e-13 45.2 In-house 64-263 (303) alignment 
Range on Protein: 1640-1833
Range on HMM: 64-263/303.0
VNTQSSDFINASFVRGNH-GRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDKSCARYWFDNGM--ATFGYLSVLTLAT---TQREGFIQRTLE
|.   | .| ||..  .   . | |..|.. | |||| ||.. .   ...|  |.. ||    . | .      |   |.           .|.  . | 
vklsdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvls

VSRGDKvRHVVEQYQFLDWPVDVIKQKKSARsLLKLIEEMREVYST-QNESPLVVHCLNGVGRTAVFCTvLECI--SQILDEDDVNVFQTVKMMRNDRMH
|| ||  .  .  ... .|| . |  . |.. ..| | ... |     . .| |   | |.||.  |.  .|    |   ..  ... . ....|| |.|
vsngdy.ksflhvhhykawphnsipsdgspk.fvkqiwqlqsvlrkysdstptvymslsgcgragtfal.fetahlslhseqasldlvkclenvrngrlh

FVQ
 ||
avq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1615-1834 2e-13 44.7 In-house 52-274 (305) alignment 
Range on Protein: 1615-1834
Range on HMM: 52-274/305.0
TAENKPKSRYGNSLPSRVNRVMLRsvNTQSSDFINASFVRG---NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDNG---
.  .. | || .      . | |   . . ||.| | .|      . |.| .. |. .|. .|| |... .   |.||    .  |  ||.||       
adiaitknryqdvpcqdqsavkld..kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

MATFGYLSVLTL---ATTQREGFIQRT-LEVSRGDKVRHVVEQYQFLDWPVDVIKQKKSArSlLKLIEEMREvystqNESPLVVHCLNGVGRTAVFCTVL
.   . . |  .      .|.  || | |...   . .  | . |. .||   .   | . | |.|.  .|       . |.||||  |.|||    .. 
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklt.s.lellsairg.....skvpivvhcsagigrtgtivaie

ECISQILDEDDVN-VFQTVKMMRNDRMHFVQT
  . .| .. ..  . . || .|..| . .|.
yilekiaenkpcppmpelvkalrdqrafsiqn
subfamily_CG42327_pd Subfamily CG42327 1617-1761 2.2e-13 44.6 In-house 27-180 (319) alignment 
Range on Protein: 1617-1761
Range on HMM: 27-180/319.0
ENKPKSRYGNSLPSRVNRVMLRSVNTQ-SSDFINASFVRGN---HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFD----NG
  |.|||. |..|    ||.|...  . .. ...||.|||    .   |...... .. .||| .. . |   |. | |  .   | ||.|.      ..
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

MATFGYLSVLTLATTQREGFIQRTLEVSRGDKVR-HVVEQYQFlDWPVDVIKQKK
  ..| . |       .. ..  || . | ||     .  | . .|.   .  ..
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaee
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1617-1834 8.6e-13 42.5 In-house 51-275 (310) alignment 
Range on Protein: 1617-1834
Range on HMM: 51-275/310.0
ENKPKSRYGNSLPSRVNRVMLRSVNTQSSDFINASFVRGNHGR--LITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRDK-SCARYWFDNGMA-TFG
..  | || . .     || |.  ...  |.| | .|. |. |  .| .. |.  |. ||| ||.. .  .|..|    .  .  |  ||   |.. |.|
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

YLSVLTLATTQREgFIQRTLEVSRGDKVRHVVEQYQFL-DWPVDVIKQKKSARSL---LKLIEEMREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQ
 . |  |. .  | |    | |.       | ||   | .  |..||  .         |     . . .     | ||||  |..|. | ...   | .
cirvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidk

ILDEDDVNVFQTVKMMRNDRMHFVQT
.   . |.. . .  ....|.  .||
ldrglkvdaeevktellksraiciqt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1281-1373 9.6e-13 42.1 In-house 4-95 (95) alignment 
Range on Protein: 1281-1373
Range on HMM: 4-95/95.0
PIPLSDFPAFVQKN--RHSTFFQEEFNDLPEANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAIlndDPDSDYFNASFIPSFQHPRRYIASQG
|| .| | . | .        |..||. .. .   | ||   . |  |||. ||.|||..|| |.      |||| || |.  .     |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_eak_pd Subfamily eak 1606-1755 4.4e-12 40.0 In-house 40-192 (332) alignment 
Range on Protein: 1606-1755
Range on HMM: 40-192/332.0
PASMIRNGTTAENKPKSRYGnSLPSRVNRVMLRSVNTQSSDFINASFVRG-NHG-RLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARY
..  |....  |.  .  ..  .|   . | | |       .|||| .   . | . | | ..  . |  || |.|. .  ||..| .| . . .   .|
rllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WFDNG--MATFGYLSVLTLATTQREGFIQRTLEVSRGDKVrHVVEQYQFLDWPVD
. |..     ||.| | .    .|. .  | ||.|.|..  | |  |..  |   
fpdktreelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtet
0048179 (Phosphotyrosine protein) phosphatases II 1743-1835 6.8e-12 40.8 In-house 48-131 (144) alignment 
Range on Protein: 1743-1835
Range on HMM: 48-131/144.0
VVEQYQFLDWPVDVIKqkKSARSLLKLIEEMREVYStqNESPLVVHCLNGVGRTAVFCTVLECIsqildEDDVNVFQTVKMMRNDRMHFVQTE
 . ||..|.||   .    ..  ||...| ..|...  .. | .|||  |||||.....   ..     . ...........|. |.. |...
egiqylhlpwpDhgvp..dllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1670-1808 7.9e-12 39.8 In-house 40-173 (255) alignment 
Range on Protein: 1670-1808
Range on HMM: 40-173/255.0
TVADFWVMILDYQPTAIIMLNDDNQ-RDKSCARYWFDNGMATFgYLSVLTLAT-TQREGFIQRTLEVSR--G-DKVRHVVEQYQFLDWPVDVikQKKSAR
||. |. .|   ... ..|| | ..   . | .|.  .       |. ....|       . ||||.    |  |  | |. |..  |.       . ||
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl.kladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekn..aPelar

SLLKLIEEMRevystqNESPLVVHCLNGVGRTAVFCtVLECISQ
 .|...  .|      .  ..|||| .|.||.| |  . | . |
eilnilkvvr......dsksvvvhCstGiGrsaafv.laelvyq
0048076 (Phosphotyrosine protein) phosphatases II 1738-1835 1.1e-11 40.1 In-house 41-129 (145) alignment 
Range on Protein: 1738-1835
Range on HMM: 41-129/145.0
DKVRHVVEQYQFLDWP-VDVIkqkKSARSLLKLIEEMREVYStQNeSPLVVHCLNGVGRTAVFCTVLECISqildeDDVNVFQTVKMMRNDRMHFVQTE
. . . . ||..|.||  .|     ... ||...| ..|... ..  | .|||  |||||....    ...      .|.........|. |...|...
ellerlgiqylylpwpDhgvp...dllellleflefieealk.eg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1617-1707 1.5e-11 38.6 In-house 46-154 (350) alignment 
Range on Protein: 1617-1707
Range on HMM: 46-154/350.0
ENKPKSRYGNSLPSRVNRVMLR---------SVNTQSSDFINASFVRGN--------HGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQR-DKS
|   | || | ||   .|| |.            ....|.|||.... .          . | |  |.|.|| ||. .||  . . |..|..|     . 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CARYWFDNG
| ||| . .
cyrYWqegs
subfamily_eak_pd Subfamily eak 1316-1471 1.6e-11 38.2 In-house 45-196 (332) alignment 
Range on Protein: 1316-1471
Range on HMM: 45-196/332.0
TVAKKQINFEKNrYKNILPYDSSRVQLAILNDDPDsDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNKIKCRQYWPET
.....  . ..|   .|.|||   |.|.    ...  | ||| .   .  |.|| .  ...  .  ||.|. ...  .| .. .  | .  |  .|.|. 
setarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

STTPLLFGDITVELESVEKCSGGSKRSFVLRKGKAkTQRFLnQFHYTKWPDRDVPR
.   | || . ||  .  | .    | ..|.||   | | |  ...  | . ..|.
treelkfGildverkefvkrniletrllelskGne.thrvl.hykvfGwtettlpk
fn3 Fibronectin type III domain 410-496 3.4e-11 36.3 Pfam-A 2-85 (85) alignment 
Range on Protein: 410-496
Range on HMM: 2-85/85.0
SPTGLQVSAINPKELEVIWEHLPsesaECRSGVTNYMIYYAPSGSTS-SSSILVFRDTSSYTIRGLDTYLDYIIQLTASNKDEESDRS
.|..|.||.... .|.. |.. .    . .. .|.| . |...|... . .. | |.|.|.|..||  . .| ....| |.. |. .|
aPenlsvsevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 314-390 3.7e-11 36.2 Pfam-A 8-82 (85) alignment 
Range on Protein: 314-390
Range on HMM: 8-82/85.0
IVSTTSTTVDLRWNEWSeeddVGDPPLVGYDVFVE-KDGAW-VTDQRVDQLTTSAIVSNLIPDTDYRFRVAAVREGTGG
. ..|||.. |.|.. .     |. |..||.| .. |.| .  . ..|.  |||.....| |.|.|.|||.|| ....|
vsevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1596-1755 5.2e-11 36.6 In-house 76-233 (244) alignment 
Range on Protein: 1596-1755
Range on HMM: 76-233/244.0
ESIKILCPDPpaSMIRNGTTAENKPKSRYGNSLPSRVNRVMLrSVNTQSSDFINASFVR--GNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDN
 | .|. |||  |....    .|  |.| | .||  .||| | |  . .  .||||||   |     | |. |. .|  ||| |.|.     ...|   .
gsqniirpdp..svmkdafnpnnswknregaglpfdfnrvpl.skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve

QRDKscarYWFDNGMATFgYLSVLTLATTQREGFIQ---RTLEVSRG-DKVRHVVEQYQFLDWPVD
. |.    || |     . |   .|.. |.|. | .     ||.    ..    .  .|  .|| |
eede....ywpdseplew.yeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsd
subfamily_hpo-7_pd Subfamily hpo-7 1669-1808 1.3e-10 35.6 In-house 45-179 (263) alignment 
Range on Protein: 1669-1808
Range on HMM: 45-179/263.0
NTVADFWVMILDYQPTAIIMLNDDNQR-DKSCARYWFDNGMATFGYLSVLTLATTQREGFIQRTLEVSR--G-DKVRHVVEQYQFLDWPVDviKQKKSAR
.|.. |. .|   ... ..|| | |    . | .|.  .      .  |   .|   .  . .|||.    |  |  | |..|..  |.    .. . ||
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek..ndpelar

SLLKLIEEMRevystqNESPLVVHCLNGVGRTAVFcTVLECISQ
. |....  |      |  .||||| .|.||.| | .| | . |
eilnilkvar......nskslvvhcstGiGrsaaf.svaElvyq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1647-1834 5.2e-10 33.5 In-house 69-261 (312) alignment 
Range on Protein: 1647-1834
Range on HMM: 69-261/312.0
FINASFVR--GNHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDD-NQRDKSCARYWFDN-GMATFGYLSVLTLATT-------QREGFIQRTLEVS
.| | ||.   .  |...|. |. ||.. || . |    |.||.|    ..  . ||.|  |  |.  .    | |   |        ..   .| | | 
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvv

-RGDKVRHVVEQYQFLDWPVDVIKqkKSARSLLKLIEEMRevystQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQT
 .       ...||.  ||   .    |  . |.|.  ..     ..  |.. ||  |||||  .. .   |. .      || ..  ..|.||   |..
vkatgqesklnhyqwaswpdhgmp..dscdtalrllsavk.....kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrv
subfamily_PTPDC1_pd Subfamily PTPDC1 1459-1553 2.2e-09 32.0 In-house 85-171 (182) alignment 
Range on Protein: 1459-1553
Range on HMM: 85-171/182.0
FHYTKWPDRDVPrNMSSLLDFISEVRKDHEQNnsPLFIHCSAGVGRTGVLITIDSVVSEAKRNKlvdifGFVSKIRQSRPNMVQTKEQYKFVYEA
..   |.| .|.  . ..|| .  |    ...   . .|| || |||||||.   | ..    .       ....|. ||. .||.|| ..| | 
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvkef
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1310-1407 5.3e-09 30.0 In-house 21-117 (332) alignment 
Range on Protein: 1310-1407
Range on HMM: 21-117/332.0
ANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAilNDDPDSDYFNASFIPSFQHPRRYIASQGPNKA-SMDDFWRMIWQENVATIAMVTNLSEGNKIK
|  ||.|  |   |.. ||   .  .| |||.||   .|   |..|||..  . .   || .| | .  .   ||||. . . . | .. .. | .| |
amtypntydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_eak_pd Subfamily eak 1490-1563 8.1e-09 29.3 In-house 236-310 (332) alignment 
Range on Protein: 1490-1563
Range on HMM: 236-310/332.0
NNSPlFIHCSAGVGRTGVLITIDSVVS--EAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLSENT
 ..|  | .. |  |.||.. || ..   ..|.. |  .  .. |... |   | .. |. |.||.||.|||  | 
sfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1642-1834 1.1e-08 28.9 In-house 72-270 (302) alignment 
Range on Protein: 1642-1834
Range on HMM: 72-270/302.0
TQSSDFINASFVRGN--HGRLITTEMPMPNTV---ADFWVMILDYQPTAIIMLNDDNQRDKsCARYWFDNGMATFGYLSVLTLATTQREGFIQ----RTL
..  ...||| |     .  .| . .|  ...   ..|| |. . . . . .|  ... .|     .| . . .. .   . . . . |   .     ..
aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryvi

EVSRGDKVRHVVEQ-YQFLDWPVDVIKqkksaRSLLKLIEEMREV--YSTQNESPLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRM
||   .    |. . | .  |... .       .  .||... .|   ... ....|.   ||.|| ..| |.   .... .....|. ..|| .|..| 
EvlPegcsnsvlanvyvltnWkqkkvp.....vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRp

HFVQT
. |..
ravds
0038934 (Phosphotyrosine protein) phosphatases II 1458-1552 7.1e-08 27.8 In-house 79-171 (194) alignment 
Range on Protein: 1458-1552
Range on HMM: 79-171/194.0
QFHYTKWPDRD--VPRNMSSLLDFISEVRKDHEQN-NSPLFIHCSAGVGRTGVLITIDSVVSeaKRNKLVDIFGFvskIRQSRPNMVQTKEQYKFVYE
 ..| |.|  |  .. ... ||.|.. | . .... .    .|| ||.||||.|.    . .   . .. .  ..   .|. ||..... .... ...
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAial...frekRpgaipnqdyleallk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1665-1835 7.3e-08 26.2 In-house 98-274 (302) alignment 
Range on Protein: 1665-1835
Range on HMM: 98-274/302.0
MPMPNTVADFWVMILDYQPTAIIMLND-DNQRDKSCARYWFDN--GMATFGYLSVLTLA-------TTQREGFIQRTLEVSR---GDKVRHVVEQYQFLD
.|  .|.  .| .| .|. . .. | .  .. .| || |. |.  |  .||  .| |.         | ...|   |.|.      .||.. |.  .|  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPVDVIKQKksARSLLKLIEeMREVYSTQnespLVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFVQTE
||     ..  | . |...    | | ..    ..||| .|||||  . ..   |   . ..  .. . |. .|. |   ||.|
wpdhGapke..aytaldilk.fcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqde
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1641-1705 7.4e-08 26.1 In-house 86-155 (349) alignment 
Range on Protein: 1641-1705
Range on HMM: 86-155/349.0
NTQSSDFINASFVRG----NHGRLITTEMPMPNTVADFWVMILDYQPTAIIMLNDDNQRD-KSCARYWFD
 ..  |.||| ...      . . |.| .|.| || ||. .||  .   .. ||||.. . . | .|| .
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1333-1465 8.2e-08 26.6 In-house 3-122 (130) alignment 
Range on Protein: 1333-1465
Range on HMM: 3-122/130.0
LPYDSSRVQlailnddpDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNkikcrQYWPETSTTPLLFGDITVELESV
|... ||.|        . .| ||||.   .. . |. .| |  ..  |||.|. .  |  . ..  . | .     .|||..        ||.| |   
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

EKCSGGSKRSFVLRKGKAKTQRFLNQFHYTKWP
..        .   .   .... |  |. ..||
defknikasnleiesdlneshqaltmfqisnwp
fn3 Fibronectin type III domain 1007-1098 1.6e-07 24.5 Pfam-A 11-79 (85) alignment 
Range on Protein: 1007-1098
Range on HMM: 11-79/85.0
SSHYWVVISWRPWNrsidAGDGPITGYIVYVHTKDGNEthsatllsdgslntgssrGRREVTsEGLDLLEYNITGLEEGTNYEIQIAVIREG
 ..  ...|| | .     |.|||||| | . .|.|.|                    .|.|    .  ....|||..||.||.... . ..
vtstsltlsWsppk....dgggpitgYeveyrekggge..................ewkeft.vprtttsvtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1365-1561 1.8e-07 24.1 In-house 114-312 (346) alignment 
Range on Protein: 1365-1561
Range on HMM: 114-312/346.0
PRRYIASQGP---NKASMDDFWRMIWQENVATIAMVTNLSEgNKIKCRQYWPETSTTPLLFGDITVELESVeKCSGGSKRSFVLRKGKAKTQRFLNQ-FH
 .. | .| |   |.. ..||| ||.||..  . ..       |      . .        | . ..       ||  |   .    . ...  . |  |
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddk.lkntttslfndenggyqytgkmfinnrra.dvsgdpkeytievlpegnsdsvicqvhh

YTKWPDRDVPRNMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKFVYEAVLEYLLS
.. |   . | .   .. .| .   ... .|  . .    | ||.  .|     . .       .|.  . .|.| ||  |..  ||  .|  |..|.  
hapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiar

E
 
k
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1773-1831 5.5e-07 23.2 In-house 256-314 (349) alignment 
Range on Protein: 1773-1831
Range on HMM: 256-314/349.0
MREVYSTQNESPLVVHCLNGVGRTAVFCTVLECIS--QILDEDDVNVfqTVKMMRNDRMHF
 |  . |.. |.|.|||  | ||| |..|.   .|  . | .. . .  ... ...| ...
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki..klqallkDlisi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1296-1398 6.5e-07 23.2 In-house 13-117 (347) alignment 
Range on Protein: 1296-1398
Range on HMM: 13-117/347.0
HSTFFQEEFNDLPEANIypqTVAKKQINFEKNRYKNILPYDSSRVQLAILN-----DDPDSDYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQEN
 ||.|.|.. .   ...   |... . . .||| |.    |..|| |.  .      |.   | ||| |   .  . || .| |   .. |||.|.   .
lstyfdenlanyspskf...tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtk

VATIAMVT
|. .  . 
vtqvvtif
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1773-1811 6.7e-07 23.3 In-house 253-291 (350) alignment 
Range on Protein: 1773-1811
Range on HMM: 253-291/350.0
MREVYSTQNESPLVVHCLNGVGRTAVFCTVLECISQILD
 .. . ... ||..|||  ||||| ...|.   .|....
aeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfei
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1312-1472 1.5e-06 21.2 In-house 16-157 (169) alignment 
Range on Protein: 1312-1472
Range on HMM: 16-157/169.0
IYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNAsfipsfqhprryiasqgpnkasmddfwRMIWQENVATIAMVTNLSEGNkikcrQY
 | . .|.  .|  |||    |     ||.|  . .|  ||| ||                           ||||. | . | .. .  . |     ..
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nf

WPETSTTPL----LFG-----DITVELESVEKCSGG----SKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRN
|||     |    ..|      . |  . |.. . |     . |.|. . . .    |. .||. ||.  ||..
wpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1367-1434 1.5e-06 21.8 In-house 237-300 (440) alignment 
Range on Protein: 1367-1434
Range on HMM: 237-300/440.0
RYIASQGPNKASMDDFWRMIWQENVATIAMVTNLsegNKIKCRQYWPeTSTTPLLFGDITVELESVEK
 .||.| |  ... ||||.. . ...|| |. .|   |   |  |||   |  . || .||     |.
afiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywp.vntrsvtfgpftvghkgsen
hEGF Human growth factor-like EGF 777-789 2.6e-06 16.2 Pfam-A 1-13 (13) alignment 
Range on Protein: 777-789
Range on HMM: 1-13/13.0
TCTCPPGFIGKNC
||.||||. |.||
tCqCppGyTGpnC
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1785-1832 3.1e-06 21.5 In-house 1-48 (69) alignment 
Range on Protein: 1785-1832
Range on HMM: 1-48/69.0
LVVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFV
.||||  | |||  | ...  ...|  |  |..|  |. ||  |   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv
PTPc_motif_SM00404 1464-1541 4.4e-06 21.6 In-house 57-129 (140) alignment 
Range on Protein: 1464-1541
Range on HMM: 57-129/140.0
WPDRDVPRNMSSLLDFISEVrkdhEQNNSPLFIHCSAGVGRTGVLITIDSVvsEAKRNKLVDIFGFVSKIRQ-SRPNMV
    .. . ....||||...    |...   ..|| ||| |.. ||.      . .  .| . . ||.. |.  .||. 
nekdklskyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerRpiispnln
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1352-1434 5.1e-06 20.3 In-house 123-200 (244) alignment 
Range on Protein: 1352-1434
Range on HMM: 123-200/244.0
DYFNASFIPSFQHPRRYIASQGPNKASMDDFWRMIWQENVATIAMVTNLSEGNkikcrQYWPETSTTPLLFGDITVELESVEK
 | ||||.  .     || .| |   .  |||.|. .  |  . ..  . | .     .|||..        |||| |   ..
tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdseplewyeeditvtltdrde
subfamily_PTEN_pd Subfamily PTEN 1451-1551 5.4e-06 21.5 In-house 74-173 (184) alignment 
Range on Protein: 1451-1551
Range on HMM: 74-173/184.0
KTQRFLNQFHYTKWPDRDvPRNMSSLLDFISEVRKDHEQNNS-PLFIHCSAGVGRTGVLITIdSVVSEAKRNKLVDIFGFVSKIRQSRPNMVQTKEQYKF
....| .. . ..  |   | ... | .......|  |....    .|| || |||||||.   .. . . .|  ..  . ...| .  . |.   | ..
dskkfdgrvavypfdDhn.ppplelleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRY

VY
|.
ve
subfamily_DSP1_pd Subfamily DSP1 1454-1546 5.8e-06 20.5 In-house 57-149 (163) alignment 
Range on Protein: 1454-1546
Range on HMM: 57-149/163.0
RFLNQFHYTKWPDRDVPR-NMSSLLDFISEVRKDHEQNNSPLFIHCSAGVGRTGVLITIdsVVSEAKRNKLVDIFGFVSKIRQ-SRPNMVQTKEQ
 | . |.| | . .| |. ..|.... . |  .. ...|  ..||| ||. |   |. .   . . || .| . | || . |. ..||.  ... 
vfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla..ylmktkrvsleeafdfvkqrRsiisPnagFvlqL
PTEN_1 1453-1510 5.9e-06 21.2 In-house 89-149 (196) alignment 
Range on Protein: 1453-1510
Range on HMM: 89-149/196.0
QRFLNQFH--YTKWPDRDVPrNMSSLLDFISEVRKDHEQNN--SPLFIHCSAGVGRTGVLIT
..| ...      ..|  .| ..|.|.|.. ..     ...      .|| ||.||.|... 
effksgveylhfpieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1312-1472 6.8e-06 19.0 In-house 15-156 (169) alignment 
Range on Protein: 1312-1472
Range on HMM: 15-156/169.0
IYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDPDSDYFNAsfipsfqhprryiasqgpnkasmddfwRMIWQENVATIAMVTNLSEGNkikcrQY
 | . .|.  .|  |||    |     ||.|  . .|  ||| ||                           ||||. | . | .. .  . |     ..
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nf

WPETSTTPL----LFG-----DITVELESVEKCS----GGSKRSFVLRKGKAKTQRFLNQFHYTKWPDRDVPRN
|||     |    ..|      . |  . |.  .    |  . |.|. . . .  . |. .||. ||.  ||..
wpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_DSP23_pd Subfamily DSP23 1474-1552 8e-06 20.6 In-house 68-140 (148) alignment 
Range on Protein: 1474-1552
Range on HMM: 68-140/148.0
SSLLDFISeVRKDHEQNNSPLFIHCSAGVGRTGVLITIDSVvseaKRNKLVdIFGFVSKIRQSRPNMVQTKEQYKFVYE
  . .|.  | .. |..|  . .||  | |||| ...   |    | .||      ....|. ||  |.| || | |..
eqvvefvr.vveeaeekneavsvhcllgrgrtgtmlacylv....kerkla.aaeaiaevrrlrpgsvetveqeklvrd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1301-1361 8.4e-06 19.6 In-house 16-76 (244) alignment 
Range on Protein: 1301-1361
Range on HMM: 16-76/244.0
QEEFNDLPE-ANIYPQTVAKKQINFEKNRYKNILPYDSSRVQLAILNDDpDSDYFNASFIPS
.|||  | . .  . || |    |  |||| ||||.| .|| |.  . .  ||| ||..| .
keefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1786-1832 8.4e-06 20.1 In-house 1-47 (69) alignment 
Range on Protein: 1786-1832
Range on HMM: 1-47/69.0
VVHCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRMHFV
||||  | |||  | ...  ...|  |  |..|  |. ||  |   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmv
subfamily_DSP10_pd Subfamily DSP10 1468-1535 9e-06 19.7 In-house 73-134 (159) alignment 
Range on Protein: 1468-1535
Range on HMM: 73-134/159.0
DVPRNMSSLLDFISEVRKdheqNNSPLFIHCSAGVGRTGVlITIDSVVSEaKRNKLVDIFGFVSKIRQ
.. ...   |.|| |.||    ..| ...|| ||. |    ..|  .. . .. .| | . ||.. | 
nlkqyfeealefieeark....kgsrvLvhCqaGisrsat.vviaYlmkh.lnlslndaykfvkekrp
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1665-1829 9.8e-06 18.4 In-house 122-289 (346) alignment 
Range on Protein: 1665-1829
Range on HMM: 122-289/346.0
M---PMPNTVADFWVMILDYQPTAI-IMLNDDNQRDKSCARYWFDNGMATFGYLSVLTLATTQREG-FIQRTLEVSRGDKVRHVVEQYQFlDWPVDVIKQ
.        | ||| || . |   . .|. ||. .. . . .  .||   .    ..    ..  |   . |.||    .   |. | .    |   ..|
lpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhh.hapwkhlqq

KKSARSLLKLIEEMREVYSTQNESPLVVhCLNGVGRTAVFCTVLECISQILDEDDVNVFQTVKMMRNDRM
   .  ..|.| ..      ||    ||  | | ||.  |   |  | |. .  . |... .| ....| 
ppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrp