Gene SpurPTP-sf1-10 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP087_AA protein Get Run
SpurP087_AA_32-302 phosphatase_domain Get Run
SpurP087_AA_317-578 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 31-463 3.2e-163 538.5 In-house 1-450 (515) alignment 
Range on Protein: 31-463
Range on HMM: 1-450/515.0
PIPLSQFATLVQKNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMD
|.||.|| . |.||||| .| |||  ||  ||.|||||....||.||||||||||||.||.| . ||.|.||||||||||    .|  ..   ||.||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPE--STSVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISE
||||.|.|||| ||||||||.|| |||| .|||.  . ||.|| | | | |. .| ||.||.| ..|| ..| | |||||||||| ||. ||.| |.| |
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQE---
|| |||| . ||..|||||||||||..|||||||.|| |. ||.| .||.|||.|||.|||.||| |.| |||| ||  .| |   .|   |  |.    
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

------VTINNKRR---C-TPLSTQT--ATKTENRSKSRYANSLPMERNRVILQSrgsSDSDFVNASFVKGNRYRFITTQMPMPNTVADFWAMVIDYQPS
      .| . .     |  | ..||  .   .|. |.||.|.||..||||||.|    | |..||| .|| .  |.|||||.| ||.|||.||.. .||
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvilds...pdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkps

TIVMLNDDNKRDKSCARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQN
||||||| .. |||||.|| |     ||  ||.||| |    .  |...||.|
tivmlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 23-314 8.3e-157 515.9 In-house 1-297 (297) alignment 
Range on Protein: 23-314
Range on HMM: 1-297/297.0
EESPKERRPIPLSQFATLVQKNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNK-ESVSKTRP
|||||||||||||.||||||||||||||.|||||||.|||.|||||||||||||.|||||||||||||.|||.||||.|||.|||....|| .......|
eespkerrpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmP

NNASMDDFWRMVWQENVNTIAMVTKLQEGTKiKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA--KTRVVNQFHFTEWPDKAVPN--STS
..|...|||.||..|.|.||.|.....|..| ||..||.......|||..|||.||....|..||.|..|||.  ..|||.|..|.|||||||..  |.|
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas

TLQKYISEVKKDHGQNSS-PLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFE
.|.|.||||.||..||.. ||||||.||||||||||.||||||||||.|||||||.|.|.||.|||.|||||||.|||||||||||||||||||||||
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 325-583 3.2e-136 448.3 In-house 28-290 (297) alignment 
Range on Protein: 325-583
Range on HMM: 28-290/297.0
INNKRRCTPLS-TQTATKTENR---SKSRYANSLPMERNRVILQSRGSS-DSDFVNASFVKGNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDN
 .....|.| . .|..|..|..   .||||.|.||....||.|...... |||.|||||||||..|.|||||||..|||||||||.|.|.||||||||||
fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddn

KRDKSCARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKDHAPYLLNLMTEVEDSFSGVAEGfPVLVHCLN
.|||.||||||||||.||| |||..||.|||.|||.||.|||..|.|||.||||||||.||.||.||||.|..||.|..||...||..||| |.|||||.
erdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.Pllvhcla

GVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEYE
|||||||..|.....|....|..||.|..||.||.||...|||.|.|.|||....|.|......
GvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 31-322 3.5e-118 389.0 In-house 2-298 (315) alignment 
Range on Protein: 31-322
Range on HMM: 2-298/315.0
PIPLSQFATLVQKNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKE---SVSKTRPNNASMD
|||..|| ..|.||||| .| |||  ||  .|..|.|| ...||.|||||||||.||.||.| . .|.|.|||.|||||.  ..    ..   |..||.|
pipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd

DFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPE--STSVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISE
||||||.||.| ||.||||.||| |||||||||.  . ||.|| | | | |. .. .| .| | . |. ..| | ||.||||||| |.. ||.| |.| |
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklike

VKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQE
|| |.|..  .||||||||||||||..|||.|||..|||. ||.| .|...|..|||.|||.|.| |.| |||| ||  .| |   .|   |  |. 
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 29-321 1.6e-104 344.4 In-house 1-256 (392) alignment 
Range on Protein: 29-321
Range on HMM: 1-256/392.0
RRPIPLSQFATLVQKNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNAS
|.||| .|| ..|.||||. .|.|||  ||  .|.|||||.|..| .||||||||||||.||.| . .| |.|||.||||||    .|  ..   || ||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVNTIAMVTKLQEGTkikcrqywpestsvnfgdivvvlssvasccgglkrtlsltKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISE
.|||||||.|||| ||||||||.||                                         || ..| | |||||||||| ||. ||.| |.| |
lddfwrmvfqenvttiamvtklkegd........................................kgddartvaqfhftewPdkdvpkhtssllkfike

VKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQ
|| |.|| . ||..|||||||||||..||||||| ||.|. ||.| .||.||..||||||||||| |.| |||| ||  .| |   .|   | .|.
vkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
subfamily_PTPRD_pd Subfamily PTPRD 29-326 6e-99 327.2 In-house 2-306 (564) alignment 
Range on Protein: 29-326
Range on HMM: 2-306/564.0
RRPIPLSQFATLVQKNRHT--DVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKE---SVSKTRPNN
..||| ..... |.| . .    | ||. .. . . |. ..|.|..| .||||.||..||.|||.|  .. |..||| |||.|   ..    .    | .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQK
 ...|||||||..|..|| |.|||.| .| || .||||... ..|...| |..         ||..|.|    ..| |.|||||.|||. ||.|. .| .
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

YISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQ
 |..|.. . ... |..|||||||||||. . ||...  .|  | |||..||...|..|..||||.|||.|.. |.|||| . .| .... ....|..|.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

EVTIN
||. .
eveed
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 38-326 5.2e-84 277.0 In-house 8-305 (318) alignment 
Range on Protein: 38-326
Range on HMM: 8-305/318.0
ATLVQKNRH--TDVFYEEFLCL-PKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWR
.. |.. |.  . .. ||.  | .. . . .. . ..||  |||| |||.||..||.|  ......||| ||.||. ..   . ..   |    ..||||
eshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWr

MVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKD
|||. |  .| |.|...| .|.|. .|||.. | ..|..|| |..  ..   . |....|.    ..|.| |.|.|.|||. ||.|...| . . .|.| 
mvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

H-GQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQEVTIN
.  .. .|..|||||||||||| . .|...  .|  . ||.|..|...|..|. ||||..||.|.| ..|||| | || ..|| . | . .|.|.  .
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpe
0050432 (Phosphotyrosine protein) phosphatases II 21-303 5e-83 274.3 In-house 15-301 (308) alignment 
Range on Protein: 21-303
Range on HMM: 15-301/308.0
RSEESPKERRPIPLSQFATLVQKNRHTDVFYEEFLCLPKANIFPQ-TVAEKKVNFEKNRYKNILPYDSSRVRLaitndDPNSDYFNASYIPVN-----KE
|... ...  .... ... |..|   .  ..|||  |..  . .. .||... |..|||||.|||||.|||.|     |..||| ||||...      ..
rdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprk

SVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPES---TSVNFGDIVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPD
 .    | . ...|||||||..||..| |.|||.|  ..|| ||||..   .|...|...| | |. .. .  .||| ||.  . ..|.|..||.| |||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

KAVPNSTSTLQKYISEVKKDHgqNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
  ||.|.. | ... .|.| .  ...| .|||||||||||... .| ..   .....||.|..| |.|. ||.||||.|||.|.| |.|| |..
hgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 31-301 4.1e-82 271.2 In-house 4-286 (288) alignment 
Range on Protein: 31-301
Range on HMM: 4-286/288.0
PIPLSQFATLVQK--NRHTDVFYEEFLCLPKANIF-PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNA
.|...... ||.|   ...  ..|||  |.. ..  ....| .. |.|||||..|||||.|||.|  ......||| |||||..   ... .    | . 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

SMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLT------KGAKTRVVNQFHFTEWPDKAVPNSTST
...|||||||..||..| |.|||.|  ..|| ||||...|...|||.| | |. .. .  .||| .|      .. ..| |..||.| |||  ||.|.. 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
| ... .|.| . ....| .|||||||||||... .| ..   .....||....| ..|. ||.|||| |||.||| |.||.|
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 21-324 4.8e-81 267.2 In-house 3-318 (330) alignment 
Range on Protein: 21-324
Range on HMM: 3-318/330.0
RSEESPKERRPIPLSQFATLVQKNRHT--DVFYEEFLCLPKANIFPQ-TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKES--
||  ..|.  |.|. ..   ...        | ||| .|| ..|     .|.|. | ||||. |||||| ||| |.  .  ..||| |||.|   ||   
rsrsgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdk

-VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLT------KGAKTRVVNQFHFTEWP
 ..   | . ...|||||.|. .  || |.|.|.|  . || ||||.  .| .|.| | .  .  .     | . ..      .  |.|.|.||||| ||
fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP

DKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRI
|  ||  .  . |.. .||| . |...|. ||||||||||| .. .|.|..  |  . ||.|. | ..|..|| ||||.|||.|.| ..||  |  || .
dvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel

QASYFESTLMHLQEVT
..| .|. | .|.. .
dvsslekhlqklynki
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 41-308 9.8e-80 263.0 In-house 20-297 (298) alignment 
Range on Protein: 41-308
Range on HMM: 20-297/298.0
VQKNRHTDVFYEEFLCLPKANI----FPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKES---VSKTRPNNASMDDFWRMV
|.|. .  .. .||  | . .     . ..||.|. | .|||| .|...|||||.|  ...| .||| |||..   |..   .   .| .... ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA--KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHG
..|...|| |.|.|.|  |.|. .|||.. . ..|.| | | |  .     .|.| ..|    |.| | |.|||.||||.||. .... .....|.. . 
teedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq

QNS-SPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRI
|.  .|..|.|||||||.|    ||||.  .|. . ||.| .|  .|..|| .|||.||| |.| |||||| | .. |
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0040438 (Phosphotyrosine protein) phosphatases II 37-320 3.6e-79 261.6 In-house 8-295 (317) alignment 
Range on Protein: 37-320
Range on HMM: 8-295/317.0
FATLVQKNRHtDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFWRMV
.  .. |. .  ...|||  |.. .. . .|||...| .||||..|||||.|||.|  .. |..||| ||||...   ... .    | . ...||||||
alldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

WQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHG
|...|..| |.|.| |  ..|| ||||. .....||..| | |.  . |   ||| ..  .. ..| |..||.| |||  || |...|.. ...|..   
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

QNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHL
....|.||||||||||||... .. ..   .....||..  | ..|. ||..||| |||.|.| |.|| |.  .|.. || . . |..|
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl
subfamily_PTPRB_pd Subfamily PTPRB 28-304 4.7e-79 260.5 In-house 3-288 (293) alignment 
Range on Protein: 28-304
Range on HMM: 3-288/293.0
ERRPIPLSQFATLVQKNRH--TDVFYEEFLCLPKA-NIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIP---VNKESVSKTRP
. .|| |..|.. |.|...     | ||.  | .  .   ...||..|| .||||.|||||| |||.|| ..|...||| ||.|||    ..| ..   |
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

NNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPES-TSVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQ
   ..||||||||......| |.|.| |. |.|| .|||.  ..|..||| | | .  .      |.|...|. ..| |.|.||| |||  ||..|.|| 
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

KYISEVKKDH--GQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSE
... .|.. .   ....|..|||||||||||.....| .. . ...  ||||| |...|..| ..|||..|| |.. .||. | ..
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 335-578 6.1e-79 260.1 In-house 35-278 (315) alignment 
Range on Protein: 335-578
Range on HMM: 35-278/315.0
STQTATKTENRSKSRYANSLPMERNRVIL-QSRGSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWS
 ...| .|.| .| || | ||....||.|     | |||..|||..|.      .|..|.| . .| ||| ||......||||... .. || .|..|| 
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

D--KGVKTFGPVSVTTLSISERRGFIEREIeVTQNkPKARHVVKQYQFVDWPTKAEERKDHapYLLNLMTEVEDSfsGVAEGFPVLVHCLNGVGRTGVFC
|       || ..|..||..   . . |.. ||..  .. . | |.|| .|| |  ...     ||.|. ||  .     . |..||||. |||||||..
drkadsvefGsikvellsleadtdgvarkl.vtrk.seesrtvtqfqftewPdkGvdkqts..sllklikevkad..ngkkefsllvhcsaGvGrtGvvi

TMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
.. |..|||.....||||..||.||..|...|||||.|||.|. . |.| 
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0046845 (Phosphotyrosine protein) phosphatases II 50-303 5.4e-78 257.5 In-house 2-276 (284) alignment 
Range on Protein: 50-303
Range on HMM: 2-276/284.0
FYEEFLCLPKANIF---PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDD-PNSDYFNASYIPVN--------KESVSKTRPNNASMDDFWRMVWQEN
..|||  |.. ...   . .|| .. |..|||||.|||||.|||.|  ...| ..|||.||||...         |. .    | . ...|||||||..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VNTIAMVTKLQEGTKIKCRQYWPEST-SVNFGDIVVVLSSVASCCGGLKRTLSLTK---GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHG--
|..| |.|.| |  ..|| ||||..  ....||. | | |.  . .  .|||.||.   . ..| |..||.|.|||  || |.. |.... .|.. .   
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

QNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTK---EVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
 ...| .|||||||||||... .| .    ....   .||....| ..|. ||.|||| |||.||| |.||.|..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 29-311 2e-77 255.2 In-house 3-289 (315) alignment 
Range on Protein: 29-311
Range on HMM: 3-289/315.0
RRPIPLSQFATLVQKN-R-HTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNN
..|||| |. | | ..     . | ...  .|  ...|  || |  | .|||| ||..|| |||.| ... ||.||| ||..|.    ..  ..   || 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEStSVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYI
||..||||.|..|.. .| |.|.| || | |. .|||.   | .| | | . |         |||| . | . | | |.|.| |||  ||..| .| ..|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnli

SEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQAS
  ||. | .. ....||||||||||| ....|.|. .|.  . .|.. ..|..||||  |||. |||||.| |.||...  || |   
rtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqd
DSPc_SM00195 64-300 3.8e-77 254.5 In-house 17-261 (263) alignment 
Range on Protein: 64-300
Range on HMM: 17-261/263.0
PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN---KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP
. | |||| | .|||||||||||..||.|  ......||| ||.|| ..   |. .    | .  ..|||||||.|.|..|.|.|. .|  |.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

ES--TSVNFGDIVVVLSSVASCC-GGLKRTLSLTKGA--KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSID
|.  .. .||.| | | .| ..     .|||.||| .  .|| |.|.....|||. ||.||. . .....|||.. ..|.|..|||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEA
... . ...|.||||  |...|..|| ||||.|||.|.| |.||.
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 64-300 3.8e-77 254.5 In-house 17-261 (263) alignment 
Range on Protein: 64-300
Range on HMM: 17-261/263.0
PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN---KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP
. | |||| | .|||||||||||..||.|  ......||| ||.|| ..   |. .    | .  ..|||||||.|.|..|.|.|. .|  |.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

ES--TSVNFGDIVVVLSSVASCC-GGLKRTLSLTKGA--KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSID
|.  .. .||.| | | .| ..     .|||.||| .  .|| |.|.....|||. ||.||. . .....|||.. ..|.|..|||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEA
... . ...|.||||  |...|..|| ||||.|||.|.| |.||.
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 43-305 8.4e-77 253.0 In-house 16-282 (288) alignment 
Range on Protein: 43-305
Range on HMM: 16-282/288.0
KNRHTDVFYEEFLCLPKAN-IFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWRMVWQENV
. |  . | ||.  |.. .    .|.... || .||||.||||||  ||.|   .. ...|| ||||| ..|   . ..   |. ....|||..|.....
sarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

NTIAMVTKLQEGTKIKCRQYWPESTS-VNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPL
.||.|.|.| || | || .|||..   .|.|.. |.| ..      ..|.| | |  . . ..|.... |||. ||.|.  | .... ||  . ... |.
stivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

LVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEaLLSED
.|||||||||||. ...| .. . .... .|..| |.|.|..|. .|||..||.|.| ..|. | .||
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls.lieed
0047943 (Phosphotyrosine protein) phosphatases II 39-301 1.6e-76 252.7 In-house 3-272 (273) alignment 
Range on Protein: 39-301
Range on HMM: 3-272/273.0
TLVQKNRHTDVFYEEFLCLPKANI-FPQTVAEKKVNFEKNRYKNILPYDSSRVRLaitnDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFWRMVW
 |..|  ......|||  |..  . .. .||... |..|||||.|||||.|||.|    .|..||| ||||...   ... .    | . ...|||||||
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvw

QENVNTIAMVTKLQEGTKIKCRQYWPEST---SVNFGDIVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKD
..||..| |.|.|.|  ..|| ||||..    |...|.. | | |. .. .  .||| ||.    ..|.|..||.|.|||  || |.. | ..| .|.| 
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

HGQ--NSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
. .  ...| .|||||||||||... .| ..   .....||.. .| ..|. ||.|||| |||.|.| |.|| |
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 54-307 5e-76 251.2 In-house 20-283 (297) alignment 
Range on Protein: 54-307
Range on HMM: 20-283/297.0
FLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLaitnDDPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEG
  .||  .... .||... | ||||||.|||||..||.|    ||..|||.||||... .   . .    | . ...|||||||..||..| |.|.| | 
eellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

TKIKCRQYWPES--TSVNFGDIVVVLSSVAS--CCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQ--NSSPLLVHCS
 ..|| ||||.    |...||..| | || .  . .   ||| .|.  . ..|.|..||.| |||  ||.|...| ..| .|.| . .  ...| |||||
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGVGRTGVLLSIDSVVAEAK---RTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTR
|||||.|... .| ..   .   ....|||. .| |.|. || .||| |||.|.| |.|| |.. .|.
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 41-323 1.4e-75 249.3 In-house 14-305 (319) alignment 
Range on Protein: 41-323
Range on HMM: 14-305/319.0
VQKN--RHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKES---VSKTRPNNASMDDFWRMVWQ
...     .  . .|| .| .|. .  . |.|. | .||||.|||.|| .|| |.  .. ..||| |||.|   .|    ..   | .  ..|||||||.
lkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

ENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA---KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQ
|.. .. |.|||.|  |.|...|||| . ...| ..| | .     .  .| |.| | .   .|| | .|..|||||..||... .| . . ...| . .
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek

-NSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQEV
 .| |. |||||||||||  . .| ..   |.   .|.| .| ..|  |. |||..|||.|.| |.|||. . || |.   ..  |..|.| 
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek
0039614 (Phosphotyrosine protein) phosphatases II 34-302 1.5e-75 249.7 In-house 18-290 (297) alignment 
Range on Protein: 34-302
Range on HMM: 18-290/297.0
LSQFATLVQKNRHTDVFYEEFLCLPKANIfPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITND-DPNSDYFNASYIPVNK----ESVSKTRPNNASMDD
   .. |. |   . ....||  |.. .. ....|....| .|||||.|||||.|||.|   .. |..||| ||||... .    . .    |.. ...|
vldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWRMVWQENVNTIAMVTKLQEGTKiKCRQYWPESTSvNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKK
||||||...|..| |.||| |  . || |||||... ..||..| | .|  . |   |||..|.. ..| |..|..| |||  ||.|...|.. . .|..
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

DHGQ--NSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALL
 . .  .. | ||||||||||||... .. ..   .....||..  | ..|. ||..||| .||.|.| |.|| |.
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 46-299 1.7e-75 249.4 In-house 18-275 (278) alignment 
Range on Protein: 46-299
Range on HMM: 18-275/278.0
HTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFWRMVWQENVNTIA
   ....||  |.. .......|... |..|||||.|||||.|||.|  .. |..||| ||||...   ... .    |.. ...|||||||...|.|| 
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttiv

MVTKLQEGTKIKCRQYWPeSTSVNFGDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVH
|.|.| |  ..|| |||| ..|...||..| | .. .. .   ||| .|  .  ..| |...|.. |||  || |.|.|.... .|..    ...|.|||
mLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVH

CSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
|||||||||... .. ..  ......||..  | ..|. || .||| .||.|.| |.||
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 337-578 3.6e-75 248.0 In-house 35-277 (515) alignment 
Range on Protein: 337-578
Range on HMM: 35-277/515.0
QTATK-TENRSKSRYANSLPMERNRVIL-QSRGSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKS-CARYWSD
|| ..   | .| || | ||....||.|     . .||..|||....      .|..|.| . .| ||| .|......||.|... .. ||. |..|| |
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

KG--VKTFGPVSVTTLSISERRGFIEREIEVTQNKPkaRHVVKQYQFVDWPTKAEERKdhAPYLLNLMTEVEDSFSGVAegFPVLVHCLNGVGRTGVFCT
|      || ..| ..|..   | | |...|....    . | |..| .|| |  ...  .  || |. ||  . . ..  .|...||. |||||||...
kpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt..hpliihcsaGvGrtGvvis

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
. ...|.... ..||||..|. .|..|...|||.|.|||.|. . |.| 
idsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 66-303 5.1e-75 246.9 In-house 2-244 (250) alignment 
Range on Protein: 66-303
Range on HMM: 2-244/250.0
TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKES---VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIkCRQYWPES
.||.|  | ||||| .|...||||| |  .. | .||| |||.. . .|.   .    | .|.. ||||||..|...|| |.|.|.|  |  . ||||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

TSVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKT--RVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQ-NSSPLLVHCSAGVGRTGVLLSIDSVVA
.. ..||. | | |        ||.| |.|  |.  |.| |.||. ||||.||. . .  .....|.. . | ...|..|.|||||||.|  . ||.|. 
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
 .|. | ||.| .. ..|..|| .|...||| ||| ..|.|| |
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPRD_pd Subfamily PTPRD 333-581 1.6e-74 246.5 In-house 37-285 (564) alignment 
Range on Protein: 333-581
Range on HMM: 37-285/564.0
PLSTQTATKTENRSKSRYANSLPMERNRVILQ-SRGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARY
  ....|.| .|..| |||| .. ...||.|.  .| ..||..||||..| |    .| || |...|..||| || ... ||||||.  . ..|  |..|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFsGvAEGFPVLVHCLNGVGRTGVFC
| .|| .|.| . ||  .  |   .. |.......| .  . |.|..|..|| .     ..|  ||.|...|...     .  |..||| .||||||.|.
WPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv..pesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfi

TMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANE
..  .. .|.||. ||..|.||.||..| . ||||| |.|..| |.|.|.. .
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 31-317 3e-74 244.9 In-house 3-299 (305) alignment 
Range on Protein: 31-317
Range on HMM: 3-299/305.0
PIPLSQFATLVQKNRHTDV--FYEEFLCLPKAnIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN---KESVSKTRPNNAS
.| |...|. ....| ..   . ...  |..    .  | .|..| .|||.|.| ..| .|..|. ......||| ||||.      |. .    | .  
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSV--NFGDIVVVLSSVASCCGGLKRTLSLTK---GAKTRVVNQFHFTEWPDKAVPNSTSTLQ
..||||....| |.|| |.|||.|| | |||||||||..   .||...| |.| ..  . ..| |....     ..|.| |...|.|||. ||.....| 
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

KYISEVKKDHGQNSS-PLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTL
. | .|.||. ..   ||||||||||||||| ...|  .  .|. ..||.|... ..|..|..||||..||.|.. |. | . . || |  | ..  .
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 47-302 5.6e-74 243.8 In-house 14-277 (281) alignment 
Range on Protein: 47-302
Range on HMM: 14-277/281.0
TDVFYEEFLCLPKANIFPQTVA-EKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFWRMVWQENVNTIA
.  | ||.  | ....   ..| ... | .||||.||  || .||... .... |.|| ||...|    .|| .    |  ||...||.|||...|..|.
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MVTKLQEGTKIKCRQYWPEST-SVNFGDIVVVLSSVASCCGGLKRTLSL-TKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNS-SPLLV
|||.  |. |.|| .|||. . ....||..|   . ..    ..|...| .....|| |.|...| |||. ||..|. | .. .||.| . ...  ||..
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGVLLSIDSVVAEAKRT-KEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALL
||||||||||. ...| .| ..... .|.|.   |...|..| .||||  ||.||| |||.|| 
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0050432 (Phosphotyrosine protein) phosphatases II 328-578 1.3e-73 243.3 In-house 52-300 (308) alignment 
Range on Protein: 328-578
Range on HMM: 52-300/308.0
KR--RctPLSTQTATKTENRSKSRYANSLPMERNRVILqsrgSSDSDFVNASFVKGN----RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR
 .     .|.. .| . ||..| || . || ...||.|    ...||..|||.|.|     . .|| || |.||||.||| || ... ..||||..   .
lsvkp..lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklven

D-KSCARYWSDK---GVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFsgvaEGFPVLVHC
. . ||.|| ..   |....|...||.||. .. ... |..|.| .. .  ..|..... .||       ...  ||... .|..|.    .| |..|||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl....pggpivVHC

LNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
 .||||||.|.... .. |...|  ||||..||.||  |.. |||.| | |.|... |||.
saGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_PTPRK_pd Subfamily PTPRK 49-323 3.5e-73 241.2 In-house 23-299 (314) alignment 
Range on Protein: 49-323
Range on HMM: 23-299/314.0
VFYEEFLCLPKAnifpQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKES---VSKTRPNNASMDDFWRMVWQENVNTIAMVT
 | ||. .|..       .| |. | ||||...||.|| |||.|  ...||.||| ||..|   | .   .    | .  . ||||.|..||  .| |.|
gfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlt

KLQEGTKIKCRQYWPESTSVnFGDIVVVLSSVASCCGGLKRTLSLTK----GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHC
.|.| ...|| .|||| |.| .||| | | ..   .  ..|.....|      ..|.|.||.|. |||  ||.|  .| |.. .||| . ..  ...|||
elvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

SAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQEV
||| ||||. . ||.|.  ..| . ||.|  | ..|.... ||.|.|||.|.| ..||| |  .| | .| |... .. ...
saGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirl
0045450 (Phosphotyrosine protein) phosphatases II 29-301 4.7e-73 241.9 In-house 8-304 (307) alignment 
Range on Protein: 29-301
Range on HMM: 8-304/307.0
RRPIPLSQFATLVQKNRHTDVFYEEFLCLPKANIF---PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDD-PNSDYFNASYI-----------PVNK
 ...  . .. |...  .   ...||  |.. ..|   . ..|....| .|||||.|||||..||.|  .... ..|||.||||.            ...
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPES-TSVNFGDIVVVLSSVASCCGGLKRTLSLT---KGAKTRVVNQFHFTEWPD
. .    | . ...|||||.|...|..| |.|.| | ...|| ||||.. .....|...| | |.  . |   ||| .|   .  ..| |..||.|.|||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

KAVPNSTSTLQKYISEVKKDHGQ--NSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKE---VDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
  || |...| . | ||.| ...  ...| ||||||||||||... .. .    .....   ||..  | ..|. || .||. |||.|.| |.|| |
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 60-301 4.9e-73 240.5 In-house 27-277 (290) alignment 
Range on Protein: 60-301
Range on HMM: 27-277/290.0
ANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCR
 ........||..| .|||||.||||| ||| |  ......||| ||..|   .   | ..   |  . .||||||.|. ||. . |. .. |  |.||.
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

QYWPES--TSVNFGDIVVVLSSVASCC-GGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLS
.||||.  ....||.. | |..   .  . | ||| ...  ..|.|.|||.|.|||. ||.|...| . |..|.. . ....||.|||||||||||....
rYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiia

IDSVVAEAKR---TKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
|| |    |.   ..|.|.|  |...|..|. .|||||||..|| ||.| .
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Ptp69D_pd Subfamily Ptp69D 40-318 6.2e-72 237.3 In-house 13-303 (307) alignment 
Range on Protein: 40-318
Range on HMM: 13-303/307.0
LVQKNRHTD-VFYEEFLCLPKANIFPQT-VAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKE---SVSKTRPNNASMDDFWRMVW
|....|.||  . .|.  |.. .|  .| |.||| |  ||||..| ..|. ||.|. .| . .||| |||.|   ||    .    | .| ..|||||..
lksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia

QENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA-------KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVK
. .|..| |...|.| .. || .|||. . |..|||.| | |  ..    .|.|...|         ..| | |.|.|.|.|  ||... .| |.|..|.
eqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

KDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLM
. . .| ||..|||||||||.|.....||.. . |  ..||||  | ..|..|. .||  |||.|.| |.|.     || ..   .|... 
elyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie
0051299 (Phosphotyrosine protein) phosphatases II 330-577 1.2e-71 236.8 In-house 35-286 (288) alignment 
Range on Protein: 330-577
Range on HMM: 35-286/288.0
RCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS-SDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD-KSC
 ...|.. .| . ||..| || . || ...||.|.. .. ..||..|||...|  .  .|| || |.||||.||| || ... ..||||..   .. . |
llpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekc

ARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQN----KPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSgvAEGFPVLVHCLNGV
|.||...|..|.|...||.||. .  ... |..||| .    ...  . |..... .||       |..  ||... .| ....  . | ||.||| .||
aqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkala..sgggpvvVHCsaGv

GRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
||||.|.... .. |...|  |||...||.||. |.. |||.| | ||||.. |||
gRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
DSPc_SM00195 330-577 3.1e-71 235.2 In-house 16-262 (263) alignment 
Range on Protein: 330-577
Range on HMM: 16-262/263.0
RctplSTQTATKTENRSKSRYANSLPMERNRVILQSRG-SSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNK-RDKSC
.    .|..| | .|.|| || | ||....||.|...  ...||..||...||  .. ..| ||.|.|.||.||| ||.. . ..||||.....   . |
k....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

ARYWSDK--GVKTFGPVSVTTLSISERR-GFIEREIEVTQNKPKARHVVKQYQFVDWPTKaeERKDHAPYLLNLMTEVEDSFSGVaeGFPVLVHCLNGVG
.||| ..  | .||| .||.. .  ...  .| |..|.|.....  . |.|||. .|| .  .  |.. ..|.|. .|. | |      |..||| .|||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts..sgpivVhCsaGvg

RTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
|||.|.|.  .. ...||. ||.|..||.||..|.. |||.| |.|.|| | ||.
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 330-577 3.1e-71 235.2 In-house 16-262 (263) alignment 
Range on Protein: 330-577
Range on HMM: 16-262/263.0
RctplSTQTATKTENRSKSRYANSLPMERNRVILQSRG-SSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNK-RDKSC
.    .|..| | .|.|| || | ||....||.|...  ...||..||...||  .. ..| ||.|.|.||.||| ||.. . ..||||.....   . |
k....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

ARYWSDK--GVKTFGPVSVTTLSISERR-GFIEREIEVTQNKPKARHVVKQYQFVDWPTKaeERKDHAPYLLNLMTEVEDSFSGVaeGFPVLVHCLNGVG
.||| ..  | .||| .||.. .  ...  .| |..|.|.....  . |.|||. .|| .  .  |.. ..|.|. .|. | |      |..||| .|||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts..sgpivVhCsaGvg

RTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
|||.|.|.  .. ...||. ||.|..||.||..|.. |||.| |.|.|| | ||.
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 333-578 3.6e-71 235.2 In-house 17-275 (284) alignment 
Range on Protein: 333-578
Range on HMM: 17-275/284.0
PLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS--SDSDFVNASFVKGN-------RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK
 ||. .| . ||.|| || . || ...||.|.| ..  .|||..|||.|.|        . .|| ||.|.||||.||| || ... ..||||..   ...
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

-SCARYWSDKG-VKTFGPVSVTTLSISERRGFIEREIEVTQNK-PKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNG
  ||.||...| |.|.|...||.||. .. ... |..|.| .. ..  . |..... .||       ...  ||... .|..... .  | |..||| .|
ekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaG

VGRTGVFCTMLECIAQINEED---AVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
|||||.|...  .. |...|.    |||...||.||. |...|||.| | ||||.. |||.
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
Y_phosphatase Protein-tyrosine phosphatase 73-299 4.9e-71 234.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 73-299
Range on HMM: 1-235/235.0
NFEKNRYKNILPYDSSRVRLaiTNDDPNSDYFNASYI---PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP--ESTSVNF
|..|||||.|||||..||.|  .... .||| ||.|.   . .|. .    | . ...|||||||||.|..|.|.|.|.|  . || ||||  |..|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIVVVLS-SVA-SCCGGLKRTLSLTKGAKT---RVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAK
||| | |  ..   . .   |.|.|.| ..    | |.|.|.|.|||. ||.|.. | ..| .|.|.. ..|.|..|||||||||||.....| .. ...
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

RTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
...|||.. .| ..|..|| |||. |||.|.| |.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 73-299 4.9e-71 234.2 In-house 1-235 (235) alignment 
Range on Protein: 73-299
Range on HMM: 1-235/235.0
NFEKNRYKNILPYDSSRVRLaiTNDDPNSDYFNASYI---PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP--ESTSVNF
|..|||||.|||||..||.|  .... .||| ||.|.   . .|. .    | . ...|||||||||.|..|.|.|.|.|  . || ||||  |..|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIVVVLS-SVA-SCCGGLKRTLSLTKGAKT---RVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAK
||| | |  ..   . .   |.|.|.| ..    | |.|.|.|.|||. ||.|.. | ..| .|.|.. ..|.|..|||||||||||.....| .. ...
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

RTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
...|||.. .| ..|..|| |||. |||.|.| |.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 42-323 2e-70 232.5 In-house 17-310 (325) alignment 
Range on Protein: 42-323
Range on HMM: 17-310/325.0
QKNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKE---SVSKTRPNNASMDDFWRMV--WQe
.| .  | |  ||  ||  .   ..|| |  | .|||.||....| ||| |   .|||.|||.||||.  .|.    ..   |. |...|.||.|  |. 
kkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.

nvNTIAMVTKLQEGTKIKCRQYWPES--TSVNFGDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDH--
   .. .|.   .. | .| .|||.    |..|| . | | ..      ..| | .   |. .|| |.||..  |.|  |..  .||  ..  ||. .  
..csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

----GQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQEV
     . |.|.|||||||||||||..|. |..|.     .|||||.| |.|..|| ||.| .|| ..| |. ||..| .| .  | ||. |  ||| 
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqer
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 334-580 7.6e-70 230.5 In-house 46-293 (298) alignment 
Range on Protein: 334-580
Range on HMM: 46-293/298.0
LSTQTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYW
 ... | |.||..| |||. ....  ||.|..  .  .||..||||... .    ||.|| |...||.||| ||.... .|||||.. .  ||  . .||
eekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkyw

SDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDsFSGVAEGFPVLVHCLNGVGRTGVFCT
 |.| .|.| ..|. ||  |   .| |...|...| . .. |.| .|. || |.. .. ..  .|.|...|.      |   ||.|.| .||||.| |. 
PdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenats..vldllrkvra.sqqqagnkpvivqCsaGvgRsGtfia

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSAN
.   . ....|  |||||.||.||..|.. |||||.|.|.||.. |.|.. 
idsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
0036941 (Phosphotyrosine protein) phosphatases II 329-582 1.7e-69 229.7 In-house 24-282 (297) alignment 
Range on Protein: 329-582
Range on HMM: 24-282/297.0
RRCTPLSTQTATKTENRSKSRYANSLPMERNRVILqsrGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SC
..  . |. .| . ||..| || . || ...||.|   ....||..|||.|.| .  ..|| || |.||||.||| || ... ..||||...  ...  |
pllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

ARYWSDK--GVKTFGPVSVTTLSISE--RRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGV
|.||...  ...|.|...||.||...    ... |..||| .. .  ..|..... .||       ... .||... .|..  .   .| |||||| .||
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp..dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGVFCTMLECIAQIN---EEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEY
||.|.|...  .. |..   .|  ||....||.||. |.. |||.| | |.||.. |.|  ...
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0040439 (Phosphotyrosine protein) phosphatases II 64-301 2.7e-69 228.8 In-house 2-246 (249) alignment 
Range on Protein: 64-301
Range on HMM: 2-246/249.0
PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP
. .||....| .||||..|||||.|||.| |... . ||| |||||..   ... .    | . ...|||||.|......| |.|.|.|  ..|| ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

ESTSVNFGDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQ--NSSPLLVHCSAGVGRTGVLLSIDS
...|...||..| | || .. .   ||| ||  .  ..| |.....| |||  || |...| ..| .|.| . .  ...|.||||||||||||... .. 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
..   .....||.. .| ..|. ||..||. |||.|.| |.|| |
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 330-577 4.2e-69 228.4 In-house 24-272 (273) alignment 
Range on Protein: 330-577
Range on HMM: 24-272/273.0
RCTPLSTQTATKTENRSKSRYANSLPMERNRVILqsrGSSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCA
 ...|....| . ||..| || . || ...||.|   |...||..|||.|.|     .|| ||.|.||||.||| || ... ..||||...  ...  ||
lkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

RYWSDKG---VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGR
.||...|   ..|.|...||.||. .. ... |..|.| .. .  ..|..... .||       ..  .||... .|.. .. . .. ||.||| .||||
qYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgR

TGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
||.|.... .. |...|  |||.. ||.||. |.. |||.| | |.||.. |||
tgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 50-315 1.5e-68 226.4 In-house 21-301 (563) alignment 
Range on Protein: 50-315
Range on HMM: 21-301/563.0
FYEEFL---CLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNS-DYFNASYIP---VNKESVSKTRPNNASMDDFWRMVWQENVNTIA
| |||       ... .. . ..|. | .|||| ||..||.|||.|. . .  .. || ||.||     .|. .    | .  .||||||.|..||..| 
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTK-----GA---KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNS
|.|.|.| .. || .|||. .|...| . | | .    .   .|||.. .     .    . ..| |.|.|.|||..||...    ...   .. . .. 
mitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaea

SPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFES
 |..|||||||||||... .|... . .. . |..|| . .|| .|...|||.|||.|.. |.|||..|..| ..|.  |.
GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
0040438 (Phosphotyrosine protein) phosphatases II 330-580 4.6e-68 225.1 In-house 29-279 (317) alignment 
Range on Protein: 330-580
Range on HMM: 29-279/317.0
RCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS-SDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSC
.... ....| . ||..| || . || ...||.|.. |.  |||..|||.|.|   . .|| || |.||||.||| || ... ..||||..   . .. |
slkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

ARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSgvAEGFPVLVHCLNGVGRTG
|.||......|.|...||.||. |  |.. |..||. .. .  . |..... .||       ..   ||... .|.....   .| |||||| .||||||
aqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp..dhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtG

VFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSAN
.|.... .. |...|  |||.. ||.||. |.. |||.| | |.|....|||  .
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0042113 (Phosphotyrosine protein) phosphatases II 66-299 1.6e-67 222.8 In-house 2-241 (245) alignment 
Range on Protein: 66-299
Range on HMM: 2-241/245.0
TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYI---PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPES
.||....| .||||..|||||..||.|  .. |. ||| ||||.    ...       | . . .|||||.|.....|| |.|.. |  ..|| ||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

TSVNFGDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHG-QNSSPLLVHCSAGVGRTGVLLSIDSVVA
.|...||..| | |. .. .   |||..|  .  ..| |...|.. |||  ||.....|.. ...|.|     .. |.||||||||||||... .. .. 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
 ......|...  | ..|. || .||| .||.|.| |.||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 318-578 1.7e-67 223.3 In-house 39-290 (297) alignment 
Range on Protein: 318-578
Range on HMM: 39-290/297.0
MHLQEVTInnkrrctPlsTQTATKTENRSKSRYANSLPMERNRVILQSRGS--SDSDFVNASFVKGNRY---RFITTQMPMPNTVADFWAMVIDYQPSTI
..|.....       .  . .| . ||..| || . || ...||.|.. ..   |||..|||.|.| ..   .|| || |.|.||.||| || ... ..|
eellslkp.......d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

VMLNDDNKRDKSCARYWSDKGVkTFGPVSVTTLSISERRGFIEREIEVTQnkPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGVAEGFP
|||.. . ... ||.||...|  |.|...||.|.. .. |.. |..|||    .  . |...|...||       ... .||... .|.. ..   .| |
vmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp..dhgvppslellleflelvrealaelpkggp

VLVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
||||| .||||||.|.... .. |...|  |||.. ||.||. |.. |||.. | |.|... |.|.
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 338-579 8.4e-66 216.7 In-house 3-244 (250) alignment 
Range on Protein: 338-579
Range on HMM: 3-244/250.0
TATKTENRSKSRYANSLPMERNRVILQSR-GSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKSCARYWSDKGV
 | | .|. | |||. ....  ||.|..  |  .||..||||..|   |  ||.|| |...|. ||| ||.... .|||||.. .  .| . .||  .. 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

KTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVEDSFSgVAEGFPVLVHCLNGVGRTGVFCTMLECI
...| | |. ||  |   .. |.. ....| . . .|.|..|| || |.    ..|   |.|...|. |    |.  ||.|.| .||||.| |...   .
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvP..evatavLellkkvqasqq.qagnaPvivqCsaGvgrsGafiaidavl

AQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSA
 ....|  ||||...|.||..|.| |...| | ||||.| ..| .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 334-582 1e-65 216.9 In-house 37-285 (318) alignment 
Range on Protein: 334-582
Range on HMM: 37-285/318.0
LSTQTaTKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYW
 |... ..  |. | |||| |. .. || ||   |. .||..||... |.|    .| .| |.|.|. ||| || . . ..|||| . . | |  ..|||
tslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryW

SDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSgVAEGFPVLVHCLNGVGRTGVFCT
 .|| ...| . |.  .  |   .. ||..||... ..  .|.||.. .|| .     ...  ||.|. .|.      ..  |..|||  ||||||||..
PskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv..pesgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfia

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEY
.   . .|..|  |||||.||.||..|   ||||. | |.|. . |.| . . 
vdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
0045098 (Phosphotyrosine protein) phosphatases II 46-301 4.5e-65 215.1 In-house 6-272 (278) alignment 
Range on Protein: 46-301
Range on HMM: 6-272/278.0
HTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRlaitnddpnsDYFNASYIPV-NKESVSKTRPNNASMDDFWRMVWQENVNTIAMV
 .|...| .  |.  ..   |.| .  |..|||||.|||||.|||.          || |||||.. .|. .    | .  ..|||||.|......| |.
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivml

TKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLT------KGAKTRVVNQFHFTEWPDKAVPNST--STLQKYISEVKKDHGQ----
|.|.|....|| |||||. |...||..| | |.  .    .||| .|      .. ..| |...|.. |||  ||...  . ..... .... . .    
telvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------NSSPLLVHCSAGVGRTGVLLSIDSVVAEAkrTKEVDIFGYVTKIRQNRPY-MVQTKEQYQFVYVAVLEAL
         .. | ||||||||||||.|  .. .       . ||.. .|...|. ||. .||..|||.|.| ..|| |
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0045450 (Phosphotyrosine protein) phosphatases II 319-577 9.2e-65 214.7 In-house 30-304 (307) alignment 
Range on Protein: 319-577
Range on HMM: 30-304/307.0
HLQEVTINNKRRCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS--SDSDFVNASFVKG----------NRYRFITTQMPMPNTVADFWAMVID
. .  ....   . . .. .| . ||..| || . || ...||.|.| ..  .|||..|||.|.           .  .|| || |.|.||.||| |. .
lkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlwe

YQPSTIVMLNDDNKRDKS-CARYWSDKG-VKTFGPVSVTTLSISERRGFIEREIEVTQN-KPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDS
.. ..||||...  ...  ||.||.|.| ..|.|.. ||.||...  |.. | .||| . . .  . |..... .||       ..   ||... ||.. 
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp..dhgvppsfeelldfieevrka

FSGVAEGFPVLVHCLNGVGRTGVFCTMLECIAQINEEDA---VDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
..   .| ||||||  ||||||.|.... .. |...|     ||... ||.||. |.. ||..| | |.||.. |.|
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 326-577 2.4e-64 212.8 In-house 27-277 (278) alignment 
Range on Protein: 326-577
Range on HMM: 27-277/278.0
NNKRRCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRG-SSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD
 . ..... .. .| . ||..| || . || ...||.|.. |   |||..|||.|.|     .|| || |.|.||.||| || ... .|||||...  ..
eellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelg

-KSCARYWSdKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSgvAEGFPVLVHCLNGV
 . ||.||. .|..|.|...||.|.. .  ... | .||| .. .  . | .|....||    .  ..   ||... .| . ..   .. |||||| .||
rvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale..dsngpvlVHCsaGv

GRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
||||.|.... .. |.. |  ||... ||.||. |.. |||.. | |.||.. |||
gRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 336-580 2.4e-64 212.4 In-house 38-286 (305) alignment 
Range on Protein: 336-580
Range on HMM: 38-286/305.0
TQTATKTENRSKSRYANSLPMERNRVILQSRGSSD-SDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNK-RDKSCARYWSD
..  .|..|..|.|...  ... .|.||. . | | ||..|||.|.|   . ..|..| |..||||||| .......|||||| .  .  .. | .|| .
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe

KGVK--TFGPVSVTTLSISERRGFIEREIEVTQ-NKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSGvAEGFPVLVHCLNGVGRTGVFC
.  .   ||..||.  | ..  ..|||...... .. |  ..| |||. ||| .     . |  ||.|. .|. . .   .| |.|||| .||||||||.
sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGv..pqfatsllslikrvqkdqkk.dkgvpllVhCsagvgRtGvfi

TMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSAN
..   . ....|. ||||...| ||..||  ||| . | |... ..|.. . 
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 68-300 3.5e-64 211.2 In-house 2-239 (239) alignment 
Range on Protein: 68-300
Range on HMM: 2-239/239.0
AEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN----KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST
|.|.||  |||| ||. || ||| |   ..|| ||| ||||.       |  ..     ..|  |||||.|||    | |.| | || | ||.||||.||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SvNFGDIVVVLSSVASCCGGLKRTLSLTKGAK--TRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEA
| .. .. | |      .  . ||. ...  .   | | |.||| |||| ||. ....     .. ||    . | ..|||||||||| .| ||... .|
s.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEA
|. | |||| ||  ||..||.|||| ||| |...|||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
Y_phosphatase Protein-tyrosine phosphatase 344-574 5.9e-64 211.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 344-574
Range on HMM: 1-234/235.0
NRSKSRYANSLPMERNRVILQSRGS-SDsdFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWS--DKGVKTF
|..| || . ||....|| |..... ||  ..||..|||     .|| ||.|...|..|||.||.... ..||||...... .. ||.||.  ... .|.
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPVSVTTL-SIS-ERRGFIEREIEVTQNKPKA-RHVVKQYQFVDWPTKAeeRKDHAPYLLNLMTEVEDSFsgVAEGFPVLVHCLNGVGRTGVFCTMLECI
| ..|..  ... .  ... |..|....| .  .. |||... .|| .    ....  ||.|...|| |    |.  ||.||| .||||||.|...  ..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg..vpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELIN
 |...|. |||.|.||.||..|.. ||..| |.|.|..| 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 344-574 5.9e-64 211.1 In-house 1-234 (235) alignment 
Range on Protein: 344-574
Range on HMM: 1-234/235.0
NRSKSRYANSLPMERNRVILQSRGS-SDsdFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWS--DKGVKTF
|..| || . ||....|| |..... ||  ..||..|||     .|| ||.|...|..|||.||.... ..||||...... .. ||.||.  ... .|.
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPVSVTTL-SIS-ERRGFIEREIEVTQNKPKA-RHVVKQYQFVDWPTKAeeRKDHAPYLLNLMTEVEDSFsgVAEGFPVLVHCLNGVGRTGVFCTMLECI
| ..|..  ... .  ... |..|....| .  .. |||... .|| .    ....  ||.|...|| |    |.  ||.||| .||||||.|...  ..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg..vpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELIN
 |...|. |||.|.||.||..|.. ||..| |.|.|..| 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN6_pd Subfamily PTPN6 48-299 6.5e-64 210.8 In-house 26-295 (306) alignment 
Range on Protein: 48-299
Range on HMM: 26-295/306.0
DVFYEEFLCLP---KANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAiTNDDPNSDYFNASYIP-----VNKESVSKTRPNNASMDDFWRMVWQENVN
  | |||  |    . . . .. ..|. | ||||||||||.| .|| |.  .. |.||| ||.||       .|. ..     .. . |||||||||| .
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

TIAMVTKLQEGTKIKCRQYWPEST-SVNFGDIVVVLSSVASCCGGLKRTLSLT---KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNS-
 | |.||  | .| || .|||... . ..|.| |   |  |      |.||..   |. ..| | |.||..|||..||...... .....|.. . . . 
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

---SPLLVHCSAGVGRTGVLLSIDSVVAEAKR---TKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
    |..||||||.|||| .. || ..   ..     ..||   | ..|. |  .|||..||.||| |. .
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
0037934 (Phosphotyrosine protein) phosphatases II 66-299 6.5e-64 211.1 In-house 3-240 (243) alignment 
Range on Protein: 66-299
Range on HMM: 3-240/243.0
TVAEKKVNFEKNRYKNILPYDSSRVRLaitnddPNSDYFNASYIPVNKESVSKTRPNNASMDD----FWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPE
..| ...| .||||..||||| |||.|      ..|||.||..|.| .       | . . .|    ||||.|......| |.|.|.| ...|| ||||.
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpg

STsvNFGDIVVVLSSVASCCGGLKRTLSLTK---GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKD--------HGQNSSPLLVHCSAGVGRTGV
..  ..||..| | |. .. .   |||.|.    .  || | ..|.. |||  ||.|.. |.....||..         .  ...|.||||||||||||.
ev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

LLSIDSVVAEAkrtkEVDIFGYVTKIRQNRPY-MVQTKEQYQFVYVAVLE
|. .. .        .||.. .| ..|. ||. .||| .||.|.| |.||
liaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 68-299 1.1e-63 209.6 In-house 3-239 (239) alignment 
Range on Protein: 68-299
Range on HMM: 3-239/239.0
AEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN----KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST
|.|.||  |||| ||. || ||| |   ..|| ||| ||||.       |  ..     ..|  |||||.|||    | |.| | || | ||.||||.||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SvNFGDIVVVLSSVASCCGGLKRTLSLTKGAK--TRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEA
| .. .. | |      .  . ||. ...  .   | | |.||| |||| ||. ....     .. ||    . | ..|||||||||| .| ||... .|
s.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
|. | |||| ||  ||..||.|||| ||| |...||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 332-582 1.5e-61 203.2 In-house 36-288 (319) alignment 
Range on Protein: 332-582
Range on HMM: 36-288/319.0
TPLSTQTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCAR
.. ....|.| ||..| || | |...| ||.|..  |. .||..||||. |  .| .|| || |. ||. ||| || ... |..|||.... . |  . .
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkk

YWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKA-RHVVKQYQFVDWPTKAeeRKDHAPYLLNLMTEVEDSFSGVAEGfPVLVHCLNGVGRTGV
||... ....| . || ..  |  ..| |.... ... .     ||..|. .|| ..    ..|  ||.|. ... | ..  .| |. ||| .|||||| 
ywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhd..vPekatslldllkrirksrektqsg.PivvhCsaGvGRtGt

FCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEY
|...   . ...|| ..|||..|..||  |   ||..| | |.|| . |...| . 
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 61-299 2e-61 202.4 In-house 8-262 (270) alignment 
Range on Protein: 61-299
Range on HMM: 8-262/270.0
NIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIP----VNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCR
.  .... |   . . |||..|||   .||||.  ..|... |.|| |..     .|. ..   | .... .||||.|.|.|..|.|.|.|.|  . || 
etsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPESTSV----NFGDIVVVLSSVASCCGGLKRTLSLT-KGAKTRVVnQFHFTEWPDKAVPNSTS------TLQKYISEVKKDHGQN--SSPLLVHCSA
.|||...      ..|.| |. .| .   | ... | |. || . |.|  |....|||..||...        | | . .|.. . .   ..||||||||
rYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
||||||.|. .| .|   ..||.||.   ....|..|. .||. |||.|.| ||.|
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0040439 (Phosphotyrosine protein) phosphatases II 337-577 6e-61 201.5 In-house 4-246 (249) alignment 
Range on Protein: 337-577
Range on HMM: 4-246/249.0
QTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWSDK
 .| . ||..| || . || ...||.|.. .|  .||..|||...|     ||| || |.|.||.||| |. ... ..||||...  .  . ||.||...
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGRTGVFCTMLE
|....| ..||.||. .  ... |..|.| .. .  . |...|..|||       .. . ||... .|.. ..   .| |||||| .||||||.|.... 
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

CIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
.. |...|  ||... ||.||. |.. ||..| | |.||.. |.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 49-298 6.5e-61 200.8 In-house 6-265 (274) alignment 
Range on Protein: 49-298
Range on HMM: 6-265/274.0
VFYEEFLCLPKaNIfPQTVAEKKVNFEKNRYKNILPYDSSRVRLAIT-NDDPNSDYFNASYIP----VNKESVSKTRPNNASMDDFWRMVWQENVNTIAM
 ...||| ||  |  .|   .   . .|||||.||| . ||| |    ..|..|.| || ||     ..|  |.   |    ..|||||..||.|. | |
dlekeflelPl.nf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTKLQEGTKIKCRQYWPESTSV----NFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQN---SSP
.|||.|  . || .|.|.....    ..||. .  ... .. .   |.|.| .  ..| |  . .|.|||. .|....|| . . ||.... ..    .|
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

LLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVL
 .||||||.||||. ..|.  | . .... ||... |...|..|  ||||.|||.... |. 
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 333-581 2e-60 199.7 In-house 37-293 (325) alignment 
Range on Protein: 333-581
Range on HMM: 37-293/325.0
PLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS-SDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKSCARYW
. . ..|.| ||..| |. | ......||.|....  ..||..|||... ..    |...|.|...|. |.| .|.|.. | .|.||  .. ...|| ||
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavyw

SDK--GVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERK--DHAPYlLNLMTEVEDSFSG-VAEGFPVLVHCLNGVGRT
 ..    ||||.. |   .| |   .. | ..| | |      |||.|.  |.    ...    ... |.|. .|..          |.|||| .|||||
pkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi.lqlvkavservtantkastpilvhcsaGvGrt

GVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL-SANE
||| ..   .|.. ||  ||.|..|| ||..|   |.| . | ..|| . |.. |.| 
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgnt
subfamily_PTPN9_pd Subfamily PTPN9 38-302 2.2e-60 199.2 In-house 7-291 (297) alignment 
Range on Protein: 38-302
Range on HMM: 7-291/297.0
ATLVQKNRHtDVFYEEFLCLPKANIFPQ-TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKE---SVSKTRPNNASMDDFWRMV
 . |.....    ..|.. . . ..  . .......| |||||...| ||..|| || ...|..||| ||...   |.    ..   | .  ..||||||
vayvkekgk.rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

WQENVNTIAMVTKLQEGTKIKCRQYWP--ESTSVNFGDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKD
|...| .| |.|.. |  ..||.||||  | .| .|||. |   .| .     .|.| ..  |  ..| |  | |. |||  ||.|...| . ...|.. 
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

HGQN-------------SSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALL
 ..                |..||||||.|||| . ..|  ... ...  ||..  | ..|. | ...|| |||.| |.||||  |
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Ptp69D_pd Subfamily Ptp69D 329-580 2.5e-60 199.2 In-house 33-289 (307) alignment 
Range on Protein: 329-580
Range on HMM: 33-289/307.0
RRCTPLSTQTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-S
.| ...||... | ||  | || .  . ...||.|.   |. |||..||||.||   . .||. | |. .|. ||| |. . .  .|||| . .  ..  
areidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkk

CARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNK-----PKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGVaeGFPVLVHCLN
||.||..   . .| . |.. | ..   .|.||..|...|      .... | ||..  |.    .  ..|  ||.|...|..  .      |..||| .
cakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklieqvrelykln..rsPivvhCsa

GVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSAN
||||.|.| ..   . |...|| ||.|..|| ||..|  .||  | | |.|  . .| |  
GvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRK_pd Subfamily PTPRK 337-579 9.2e-60 197.1 In-house 36-280 (314) alignment 
Range on Protein: 337-579
Range on HMM: 36-280/314.0
QTATKTENRSKSRYANSLPMERNRVILQSR-GSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD-KSCARYWSDK
..| | |||.|.|. . |...| ||.|..  | ..||..||... . .    || || |...||.||| .| |.. ..||||..  .     | .|| ..
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GVKtFGPVSVTTLSISERRGFIEREIEVTQ--NKPKARHVVKQYQFVDWPTKaeERKDHAPYLLNLMTEVEDSFSGvAEGfPVLVHCLNGVGRTGVFCTM
. . .|.. |. .. .    .. |   |..   . .....|.|.||. ||.   .   .|  ||.|. .|. |     .| ...|||..| ||||.|...
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaG.rivvhCsaGaGrtGtfiai

LECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINE-YLSA
   .  |..|. ||||..|| ||.... .|.||| | |.|. | |  |  
divldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcg
subfamily_PTPN3_pd Subfamily PTPN3 65-300 1.6e-59 196.1 In-house 33-274 (280) alignment 
Range on Protein: 65-300
Range on HMM: 33-274/280.0
QTVAEKKVNFEKNRYKNILPYDSSRVRLAitnDDPNsDYFNASYIPVNKES-------VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQ
 ..| |  | .||||..|||||. ||.|    . .. || ||.|. .. .|       ..   | . .. |||.|||......| |.| | |  ..|| |
isaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPEST-SVNFGDIVVVLSSVASCCGGLKRTLSLTKGA--KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSI
||||.. ....|.. |.... ..    . | | |.. .  . | . |. ...|||..||.... . .....|.| .  ...|..||||||.||||||. .
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEA
.  .|   ....| .   | ..|. |  .|||..||.||  |.|..
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0042113 (Phosphotyrosine protein) phosphatases II 338-577 1.8e-59 196.5 In-house 3-243 (245) alignment 
Range on Protein: 338-577
Range on HMM: 3-243/245.0
TATKTENRSKSRYANSLPMERNRVILQSRGSS-DSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWSDKG
.| . ||..| || . || ...||.|.. |.. |||..|||.|.|     .|| || |.|.||.||| |. ... .|||||...  ...  ||.||....
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPtkAEERKDHAPYLLNLMTEVEDSFSGvAEGFPVLVHCLNGVGRTGVFCTMLEC
..|.| ..||.||.    ... |..||| .. .  . | .|....||       |.  .||... .|..  .   .. ||||||  ||||||.|.... .
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp..dhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm

IAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
. |...|  |.... ||.||. |.. |||.. | |.||.. |.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 334-580 2.7e-59 196.2 In-house 23-275 (278) alignment 
Range on Protein: 334-580
Range on HMM: 23-275/278.0
LSTQTATKTENRSKSRYANSLPMERNRVIlqsrgssdsDFVNASFVKGNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWSDK
 .  .| . .|..| || . || ...||.         |..|||...| . .|| || |.|.|||||| |. ... ..||||..   .  . ||.|| ..
seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

GVKTFGPVSVTTLSISERRGFIEREIEVTQN----KPKARHVVKQYQFVDWPTKAEERKDHAPYLLNLMTEVEDSFS-----------GVAEGFPVLVHC
|..|.|...||.||...   .. | ..||      .    . |...... ||       ..  ..|.|. ....  .              .| ||||||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

LNGVGRTGVFCTMLECIAQIneEDAVDVFQMVKMLRNERMH-FVQTEEDYAFVYELINEYLSAN
  ||||||... .  .. ..  |. ||... ||.||. |..  ||..| | |.||.. |.|. .
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 335-575 2.7e-59 195.6 In-house 38-277 (288) alignment 
Range on Protein: 335-575
Range on HMM: 38-277/288.0
STQTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD-NKRDKSCARYWS
|.... ...| .| || | ||.. .|| |.     ...|..|||...|..   ..|.|| |...|| ||| .| ... ||||||..  .. .. | .|| 
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP

DKGV-KTFGPVSVTTLSISERRGFIEREIEVTqnKPKARHVVKQYQFVDWPTKAeERKDHAPyLLNLMTEVEDSFSgvAEGFPVLVHCLNGVGRTGVFCT
|..  | .| | || ..  |   |..|....   | | .  ..|||.  || .    ...|| ||.|.. |. . .  |.  |..||| .||||||.| .
dadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhg.vPeskap.llellrqvkvanq..adtgpiivhCsaGvGrtgtFia

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINE
.   | ...||| .||. .|. ||..|. .|||.. | |.|| . .
ldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN13_pd Subfamily PTPN13 66-301 3.5e-59 195.3 In-house 30-269 (273) alignment 
Range on Protein: 66-301
Range on HMM: 30-269/273.0
TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDdpnsdYFNASYI--PVNKES---VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP
.|..|| | .||||.|.|||| .||.|          | |||.|  ||.|.    .    |   ...|||.|||. ... |||||. .|. |.||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

ESTS--VNFGD-IVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGqNSSPLLVHCSAGVGRTGVLLSID
||..  .   . . | |  |    |   |.| ...   ...| | ...|..|||  ||.|.  | ....||.. .  ...|..||||||.||.|.|..||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

SVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
 |.   .| ||.|.   | |.|. |  .||||.|| ||| |.||.|
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 56-308 4.1e-59 195.4 In-house 44-298 (319) alignment 
Range on Protein: 56-308
Range on HMM: 44-298/319.0
CLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN---KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTklqegtK
|   .|   || |. . | .|||. |||..| ..|.|  ..    ||| |||..      .  ..   | . ...|||||.|. |. || ..|      |
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......k

IKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA---KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDH--GQNSSPLLVHCSAGVGR
 || ||||  . .. .   | ..||  .     | . |.. .     | ..||||  |||. ||...| | . .  |.. .   ..  ...|||||||||
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

TGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRI
||| . .| ..   |. | ||.. .|  .||.|. .||   ||.|.|.|.||  |   . .
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 60-313 2.8e-58 192.7 In-house 12-267 (284) alignment 
Range on Protein: 60-313
Range on HMM: 12-267/284.0
ANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVN---KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTklqegtKIKCR
.|   || |. . | .|||. .||..| ..|.|  .     ||| |||.|      .  ..   | . ...|||||.|. |. || ..|      | || 
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

QYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA---KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDH--GQNSSPLLVHCSAGVGRTGVL
||||  . .. .   | ..||  .     | . |.. .   . | ..||||  |||. ||...| | . .  |.. .   .. ....|||||||||||| 
qywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

LSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYF
. .| ..   |. | ||.. .| ..||.|. .||   ||.|.|.|.||  |   . .    |
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdf
subfamily_PTPRB_pd Subfamily PTPRB 335-582 3.6e-58 191.9 In-house 42-290 (293) alignment 
Range on Protein: 335-582
Range on HMM: 42-290/293.0
STQTATKTENRSKSRYANSLPMERNRVIL-QSRGSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWS
....|....||.| || | || . .|| | . ...|.||..||....|..    ||.|| |.|.|| ||| || . . |.|||| .   . |  | .|| 
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

DK-GVKTFGPVSVTTLSISERRGFIEREIEVTQnkPKARHVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGRTGVFCT
..    ..| ..|| .. .| . .. ||.....   |... |.||.|. ||       ...  ||... .|... .  |.  |..|||  ||||||.| .
adeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvP..ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfia

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEY
. . . .|.||| ||.| .|  ||.||...||||..| |... . ..|. .| 
ldrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_PTPRA_pd Subfamily PTPRA 337-577 4.3e-58 191.7 In-house 51-295 (330) alignment 
Range on Protein: 337-577
Range on HMM: 51-295/330.0
QTATKTENRSKSRYANSLPMERNRVILQ-SRGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWSDK
..|.| ||. |.|. | || . .||||.  .|  .||..||||..| .   .||..| |  .|| ||| |. ... .||||| . ..| .. ||.|| |.
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

GVKTFGPVSVTTLSISERRGFIEREIEVTQ----NKPKARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDSFSGVAEgfPVLVHCLNGVGRTGVFC
|. |.| . |.     .   .  |.. |.|     . |.  .|.|. |  ||      .     .|.|. .|.      |.  |. |||  |||||| |.
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG..mlkllkkvkklnqqsag..pivvhcsaGvGrtGtfi

TMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
..   ..... |  ||||..|| ||. | . |||.| | |.|. . || 
vldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 74-299 6.8e-58 190.7 In-house 4-237 (237) alignment 
Range on Protein: 74-299
Range on HMM: 4-237/237.0
FEKNRYKNILPYDSSRVRLAITNDDpnSDYFNASYIP----VNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST-SVNFG
  |||| ||  || ||| |  .  .  ||| ||.|.       |. ..   | ..| ||||.|||||.   | |.| | || ..|| .|||..     .|
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

DIVVVLSSVASCCGGLKRTLSLTKGA---KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEV--KKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKR
 . | |      .    |.| |.|     . |.. |..|| |||. ||. |..| ..  ..  .  | ..|.| ..||||||||||..| ||... .|| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

TKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
 | |||. ||  | ..|||..|||.|| |.. ..||
kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 335-579 1.4e-56 186.5 In-house 37-285 (290) alignment 
Range on Protein: 335-579
Range on HMM: 37-285/290.0
STQTATKTENRSKSRYANSLPMERNRVILQSR-GSSD--SDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARY
...... ..|. . |.|| .. . ||..|.   |  |   ...||...||  .....| || |..||..||| .. . . . |||| . .. .|  |  |
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKP-KARHVVKQYQFVDWPTKAeERKDHAPyLLNLMTEVEDSFSGVAeGFPVLVHCLNGVGRTGVF
|.|...|..|..|.. |. ..  ..|||..||....  .|.. |.|||.  |. .  . ....   | ...|...         ...||| ..|||..||
Wpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqt.illvieemyktqrkrg.ntsivvHCSdtvgrsavf

CTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSA
|..   | . . |  .||||..| .|  ..  |||.. | ...... .||. 
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 32-303 3.7e-56 185.1 In-house 2-285 (290) alignment 
Range on Protein: 32-303
Range on HMM: 2-285/290.0
IPLSQFATLVQKNR--HTDVFYEEFLCLPKAN-IFPQTVAEKKVNFEKNRYKNILPYDSSRVRLA-ITN-DDPNSDYFNASYIPV---NKESVSKTRPNN
||...|.  |....   .. | ..|  | ...  .  ||.  . | ..||..||..||  |. |  |..  | . .| ||.||     .|. .    | .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGAK---TRVVNQFHFTEWPDKA-VPNSTSTL
  . |||...|||.|  | |.|. .|  | ||.||||.| . ..| . . |..  .. .  .|.|....  .   .. | |...| |...  |.| .. |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

QKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
. .   .|. . .   ...||||..|||..|.....  .  .| .  .|.|  . . |. .| .|||..|||...  ||..| |
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN23_pd Subfamily PTPN23 66-300 3.9e-56 185.0 In-house 36-279 (288) alignment 
Range on Protein: 66-300
Range on HMM: 36-279/288.0
TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDdpnsDYFNASYI----PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPE
..|  |.. ||||...|||||..|| |  ..|    || |||..    |.  . .    | . .. |||.||... ...| |... .|  | |. .||||
siaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

S--TSVNFGDIVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKK----DHGQNSSPLLVHCSAGVGRTGVLLS
.   .|.|||. | |.|| .     .|.|.|.     ... |   ..|.||.  ||.| .|| ... ||..     . .   ||.||||||||||||.  
dkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal

IDSVVAEAKRTKE-VDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEA
. ..|.| .. .  .||   | ..|..| .|||.|||..|.| |||||
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN6_pd Subfamily PTPN6 332-581 4.8e-56 185.0 In-house 42-301 (306) alignment 
Range on Protein: 332-581
Range on HMM: 42-301/306.0
TPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSSDSDFVNASFVK----GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCA
. || . ..|.||..| || |.||.. .||||.. . ..||..||...|    |.. ..|.||  ...||.||| || . .   |||.  .. |  . ||
kllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCa

RYWSDKGV-KTFGPVSVTTLSISERRGFIEREIEVT-QNKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSGVA--EGFPVLVHCLNGVG
||| |.   ...| .|||..| .. . .| ||. |. ..| |  . | ||.| .|| ..   . .   .|.....|.   . ..  |  |..||| .|.|
rYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgv..pkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiG

RTGVFCT---MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANE
||| |     .|. | .   .  .|. ..||..|. |  .||||. | |||. |..|. ...
RtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 32-307 8.5e-56 184.0 In-house 2-284 (287) alignment 
Range on Protein: 32-307
Range on HMM: 2-284/287.0
IPLSQFATLVQKNRHT--DVFYEEFLCLPKANIFPQT--VAEKKVNFEKNRYKNILPYDSSRVRLAitndDPNSDYFNASYIPVNKES---VSKTRPNNA
||...|. .|.|....  . | . |  | . .  ..   ..  . | .|||...||..|  || |     . . || ||..|   ||.   .    |   
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKGA---KTRVVNQFHFTEWPDKA-VPNSTSTLQ
 . .||......||..| |.....| .. .| |||||..|| .|.  . | .     | ..|.| ...     ... |.|...|.|...  |..  . | 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

KYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTR
     .|... .  ....||||..|||........  . ..|.   .|.|  . . |. .| .||| |||.|.. .||| | | .|.
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_CG7180_pd Subfamily CG7180 35-304 3.1e-55 181.9 In-house 3-293 (296) alignment 
Range on Protein: 35-304
Range on HMM: 3-293/296.0
SQFATLVQKNRHTDVFYE-EFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFW
..|  ||.| |.  | |. |.   |. .|     . .| | ||||. ...|||  || |   . . .||| ||.|.     .|| .    | . ..|.||
kkflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefW

RMVWQENVNTIAMVTKLQEGTKiKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKG------------AKTRVVNQFHFTEWPD-KAVPNSTS
|.|..|..... ..||  . .| .. .|||. .  ..|.|.| . .. .     .||. |||             |.||.| .|..|||.  . || ||.
rlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstn

TLQKYISEVKKDHGQN-----SSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSE
.| . .  |..  ...      .|..|..| |..|.|| |.||  .  .....|||.|..| ..|..|| .|...|.|...|  .|||.| .
alielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_PTPRG_pd Subfamily PTPRG 325-583 4.8e-55 181.8 In-house 28-293 (563) alignment 
Range on Protein: 325-583
Range on HMM: 28-293/563.0
INNKRRCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSSDS--DFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLND-DN
....   . | .... |.||. | || | ....| || |..    ..  |..||....| .    ||.|| |...|. ||| |. . . ..|||. .  .
lqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlve

KRDKSCARYWSDKGVKTFGPVSVTTL-----SISERRGFIEREIEVTQNKP-KARHVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVedSFSGVAEGFPV
.  . | .||   ...|.| ..||       ...  | .. ..... ..|  .  ..|.||.. .|| ..    .|. . |. .     | .  ||  |.
rgrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP..ehslpvLifvkks..saankaeaGPi

LVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEYE
.||| .||||||... .   . ||..|.||.||...|..| .| . |||||.| |... . | ....| |
vvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 63-316 7.2e-55 180.9 In-house 23-281 (283) alignment 
Range on Protein: 63-316
Range on HMM: 23-281/283.0
FPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDdpnsDYFNASYIPVNKES------VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCR
 . ..|  . | .|||...|.|.|  ||.|   .     || ||..|||.|.       .    | .  . |||.||..|.. .| |.|||||. .||| 
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPESTSVNFGDIVVVLSSVASCCGGLKRTLSLTKG---AKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLS
||||.  |...|.  | |    .     .. | | .     .| ..  . . .| .        .| |.   . .   .. .|..||||.|.|||.|...
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfia

IDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFEST
. . | .|.    ||.|  |. .|..|. .|||..||..|. .|||  |  ||.| |  . ||
asasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 339-581 1.6e-54 179.8 In-house 42-282 (287) alignment 
Range on Protein: 339-581
Range on HMM: 42-282/287.0
ATKTENRSKSRYANSLPMERNRVILQsrgSSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD-KSCARYWSDKGVK
.  ..|. | |... |. . .||.|.     . |..||.|..|  ....|| .. || ||. .|| .. | ....|||| ...  | . | .||...   
niasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksv

TFGPVSVTTLSISERRGFIEREIEVTQ-NKPKARHVVKQYQFVDWPTKAEeRKDHAPYLLNLMTEVEDSFSGvAEGfPVLVHCLNGVGRTGVFCTMLECI
..|. ... |.     |.|||..||.. || .... |||||. .|. . .  ....  || .   .       ... ...||| ..|||...|| .   |
vlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgk.vtepqtillvieemyktqrkr.gnt.sivvhCsdtvGrsamfcaaatti

AQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANE
 . ..| ..||||..|  |  ... ||| | | |..... |||.. |
nkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
0037934 (Phosphotyrosine protein) phosphatases II 338-577 4.1e-54 179.0 In-house 4-242 (243) alignment 
Range on Protein: 338-577
Range on HMM: 4-242/243.0
TATKTENRSKSRYANSLPMERNRVILqsrgsSDSDFVNASFVKGNRyRFITTQMPMPNTVAD----FWAMVIDYQPSTIVMLNDDN-KRDKSCARYWSDK
.| . ||.|| || . ||....||.|     ..||..||..... . |.| ||.|.|.||.|    || |. ... ..||||...  .  . ||.||...
iallpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

GvkTFGPVSVTTLSISERRGFIEREIEVTQNK-PKARHVVKQYQFVDWPtkaeerK----DHAPYLLNLMTEVEDSFSG------VAEGFPVLVHCLNGV
   |.|...||.||...  ... |.....  . ..  . | .|... ||           |.   ||... || .  .         .| ||||||  ||
v..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp......dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGVFCTMLECIAQIneeDaVDVFQMVKMLRNERMH-FVQTEEDYAFVYELINEYL
||||...... .. ..   . ||... ||.||. |..  |||.. | |.||.. |.|
gRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 309-578 5.3e-54 178.1 In-house 6-278 (290) alignment 
Range on Protein: 309-578
Range on HMM: 6-278/290.0
QASYFESTLMHLQEVTINNKRRcTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSSD-SDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVI
.   |..  ..|.... . |.  .  ||....|.||. | || . || . .|| |.   ... ||..||.|.||  .. ..| .| |.|.|. ||| |..
geeefakefqklkklsekykae.kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

DYQPSTIVMLNDDNKRDK-SCARYWSDKGVK-T-FGPVSVTTLSISERR-GFIEREIEVTQNkpKARHVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVE
... . .||.      .|  |.|||...| . . ||...||. .      .|. | ..|...  |....|.|... .|| .       |  ||.|...|.
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvP..ssaksllelielvr

DSFSgvAEGFPVLVHCLNGVGRTGVFCTMLECIAQINE---EDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
.  .  .|  |..|||  ||||||. ...     ....   .. .|||..|  ||..|   |||.| | .||. . |...
elqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN14_pd Subfamily PTPN14 39-301 8.5e-54 177.6 In-house 15-296 (300) alignment 
Range on Protein: 39-301
Range on HMM: 15-296/300.0
TLVQKNRHTDVFyEEFLCLPKANIFPQ-TVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDpNSDYFNASYIPVNK-----ESVSKTRPNNASMDDFWRM
.| .| ... ||  |.  .|| .   . ..|. ..| ||||.|..|||. .||.|. |... ...| ||| | |       . .    | .  . |||.|
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqm

VWQENVNTIAMVTKLQEGTKIKCRQYWPES----TSVNFGDIVVV--LSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEV
||...|. |.|.|. .|. | |. .|.|..     .|.||   |.  .|. ....   . .|      . | |  . .|.|||. ||.  ..  .|. ||
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev

KK--DHGQN-------SSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
.    . ..       . |.||||||||||||||.  | ..|  .  .|.||   ....|. | ..|||  ||.||| .... |
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 337-576 8e-53 174.4 In-house 42-278 (315) alignment 
Range on Protein: 337-576
Range on HMM: 42-278/315.0
QTATKTENRSKSRYANSLPMERNRVIL-QSRGSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKSCA-RYWSDK
..| |.||. | || | ..... || |      ..||.|||.|..|  .  |.|..| | ...| ||| .| ... ..||||..  ...|. | .|| ||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

GVkTFGPVSVTTLSISERRGFIEREIEVTQnKPKARHVVkQYQFVDWPtKAEERKdHAPYLLNLMTEVEDSFSGVAegFPVLVHCLNGVGRTGVFCTMLE
 | ..|...||  |      .  | . |.  . . |.|| |...  || ...  | ..  |.||.  |       .   ...||| .|||||| |.|.  
kv.iyGkitvtrkseevnteytvrtlsvvf.gdnirevv.qlhytswp.dmgvpk.ytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitlda

CIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEY
 . |.. |.|.||..... .|. |.. ||. | | |.|. . | 
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 328-580 8.8e-53 174.7 In-house 44-295 (319) alignment 
Range on Protein: 328-580
Range on HMM: 44-295/319.0
KRRCTPLSTQTATK-TENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNddnkrDK
 .. ..|..|| .   .|. | |. | |. ..|.| |.   |   ||..|||||.|   . ..|..| |..||.|||| |. .|. ||||.|       .
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....kd

SCARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQ-NKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVG
 |..||  |.|.. .   |   |. |   .. |.||...  | |    ..|. |  || .     |..  |. |.  |.   |   .  ...|||  |||
kcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGv..pdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYEL-INEYLSAN
||||. ..   . ...||. |||...|. ||..| ..||   .| |.|   ..|.| ..
rtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_PTPRN_pd Subfamily PTPRN 54-299 1e-52 173.7 In-house 37-290 (297) alignment 
Range on Protein: 54-299
Range on HMM: 37-290/297.0
FLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYI----PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQE
 ||  .|.   ..||... | .|||.|..|||| |||.|  .... .||| ||| |    | .   ..   | .... |||.|||.. |  | ..|.|.|
alcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrlee

GTKIKCRQYWPESTSVNFGDIVVVLSSVAS-CCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVG
    .|..|||.  |  ..   | | |    |   | |.. |   .  .|| | ||||  ||...|| |. .| ..   | | .   |.|..||||.|.|
egvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGVLLSIDSVVAEA-KRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
|||| . || |..   |  ||.||   . ..|..|| .|.||.|..|.. || |
rtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 332-581 2.9e-52 172.9 In-house 12-260 (284) alignment 
Range on Protein: 332-581
Range on HMM: 12-260/284.0
TPLSTQTA-TKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNddnkrDKSCAR
.....||     .|. | |. . |. ..|.| |.   |   ||..||||..|   . ..|.|| |..||.|||| |. .|. ||||.|      .. |..
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsq

YWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQ-NKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGRTGV
||  |.|.. .   |   |..|   .. |.||...  | |    ..|. |  || .     |..  |. |.  |.   |   .  ...|||  |||||||
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgv..pdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELI-NEYLSANE
. ..   . ...||. |||...|. ||..| ..||   .| |.|  . .|.| .. 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 342-578 4.8e-52 171.7 In-house 26-269 (274) alignment 
Range on Protein: 342-578
Range on HMM: 26-269/274.0
TENRSKSRYANSLPMERNRVILQSRGSS--DSDFVNASFVKGNRYR---FITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWSDKGVK
. . .| || . || |. ||.|.|. |.  ||...|| ..|| ...   .. || |.|||||||| |.   . . |||| . . ...  ||.|. |.   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----TFGPVSVTTLSISERRGFIEREIEVTQNKPkARHvVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSGVAEG-FPVLVHCLNGVGRTGVFCTM
    ..| |.... .| || ..  |.. . . .   |. || | . ||| .     |.|  ||.|..|||.| .  ..   ||.|||  |.||||.| ..
eiserygdveikvekiverndysvrklvlkyler.ers.vkhywytdWPdhks..PddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

LECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
. .. |..||  |||...|  || .|   |||.| | .... . .||.
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN1_pd Subfamily PTPN1 58-312 2.9e-51 168.9 In-house 17-284 (290) alignment 
Range on Protein: 58-312
Range on HMM: 17-284/290.0
PKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDdpnsDYFNASYIPVN---KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIK
 .|. ||...|... | ..|||... ||| ||..|  ..     || ||| . ..   .. .    |    .| ||.|||...  .. |. |. |  .||
keasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CRQYWPES---TSVNFGDIV--VVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDH--GQNSSPLLVHCSAGV
| ||||.     .. . |.   | | |  .      |.| |..    .||.. .||.| ||| .||.| ... |.. .|..     ..  | ..|||||.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGVLLSIDSVVAEAKRTKE---VDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE--ALLSEDTRIQASY
||.| .  .|..... .....   |||   . ..|. |  ..||..| .| |.|.||   .. .|. .|  .
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrw
subfamily_CG7180_pd Subfamily CG7180 337-578 7.1e-50 164.3 In-house 35-291 (296) alignment 
Range on Protein: 337-578
Range on HMM: 35-291/296.0
QTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKSCARYWSDKG
... ..||| | |. . .| . |||.|..  | ..||..||..| .      .| |..|. .|| .|| .| | . |..|.| .     | .  ||  |.
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks

VKTFGPVSVTTLSISERRGFIEREIEVTQN--------KP--KARHVVKQYQFVDWPTKAEERkDHAPYLLNLMTEVEDSFSGV---AEGFPVLVHCLNG
 . .|.. | ...  .   .  |.. .|..        |.      .||..|.  |. . .     .  |..|.  |.     |    |  ||.|.. .|
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP.lstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
..|.||....  .. ....|. ||||..||.||..| . |.. |.| ..|....|.. 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 65-313 9.2e-50 164.4 In-house 40-291 (439) alignment 
Range on Protein: 65-313
Range on HMM: 40-291/439.0
QTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPV---NKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKikcrqYWPE
 ..| .. .  |||||.. ..| .|| |  .   | | |.|| ||     .|  ..   |.. . |||||.|..... || |.|.| |  |     ||| 
aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

STSVNFGDIVVVLSSV----ASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKD-HGQNSSPLLVHCSAGVGRTGVLLSIDS
.. | .|||.|           .  |.|      .. | | | |||.. |||| ||  .| . ...  ..     ..  |..||||||||||| ....| 
daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdi

VVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYF
 . . |  ..||| | |. .|..|  |||.  || |.| |||| .   |. ..   |
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_PTPN23_pd Subfamily PTPN23 335-576 1.4e-49 163.4 In-house 34-279 (288) alignment 
Range on Protein: 335-576
Range on HMM: 34-279/288.0
STQTATKTENRSKSRYANSLPMERNRVILQsrgSSDSDFVNASFVKGN---RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKS-CARYWS
.. .|    . .| |. . || ..||| |.   .|  |..||||||.       ||.|| |...|..||| || . . |.|||| . ....|  ..||| 
krsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

DK-G-VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVEDSFSGVA--EGFPVLVHCLNGVGRTGV
 . |  ..||..|||  |  |   ..||..... ....| . |.  |.  ||       .    ||... |||.... |      |..|||. |||||||
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvP..asPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

FCTMLECIAQINEEDA-VDVFQMVKMLRNERMHFVQTEEDYAFVYELINEY
|. .   ........  .|. |.|. ||..| . ||..| . |.|| . |.
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN9_pd Subfamily PTPN9 337-577 3.3e-49 162.5 In-house 35-290 (297) alignment 
Range on Protein: 337-577
Range on HMM: 35-290/297.0
QTATKTENRSKSRYANSLPMERNRVILQSR-GSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWS--
... .  | .| ||.. | ... || |... . . ||..||.|| | .    ||.|| |...|| ||| || . .  .|||      |    |..||   
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKD---------HAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGV
.. .. || .||..... |.. . .| .|... | .    |  .||. ||     .              .   ...|. |.  | ..| |..|||  |.
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
|||| |.|.  |.....|.. |||.. ||.||. | . .||.| |.| |  . || 
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN3_pd Subfamily PTPN3 330-574 5.8e-49 161.5 In-house 27-272 (280) alignment 
Range on Protein: 330-574
Range on HMM: 27-272/280.0
RCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSrgsSDSDFVNASFVK------GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK
.   |....| |.|| || || . || .  ||.|..   |..|..||..|.      |   |.|.|| |...|..||| || . . |.|||| .   | .
kkpglaisaarkpenlsknryrdilpydatrvklke...setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

-SCARYWSDKG-VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEDSFSGVAEgfPVLVHCLNGV
  | .|| ...   ..|  ||.  . .|.. .. ||. ..... | .. . | |...|| ..    |..  .|.....|..  ||  |  ||.|||  |.
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgv..Pddsadflefvervrklrsgkee..PvvvhCsaGi

GRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELIN
|||||. ..  ..| |.....| . ..|...|. |. .|||.. | || | | 
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 336-579 8.2e-49 161.2 In-house 32-278 (281) alignment 
Range on Protein: 336-579
Range on HMM: 32-278/281.0
TQTAT-KTENRSKSRYANSLPMERNRVIL-QSRGSSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWS
| ||. . ||. | || |    .  || . ..  ....|..||.||.|  .  ..|.|| |.|.....|| ||.... |.|||.  . . .|  | ||| 
tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP

DKG-VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHvVKQYQFVDWPTKAEErkDHAPYLLNLMTEVEDSfSGVAEGFPVLVHCLNGVGRTGVFCT
|.    ..| | |.... .|.. .|||........ ..|. |.| ... || .     . .  ||.  .||.   .   .  |...||  ||||||.. .
ddnselkygdvtvkstaeeekatyierkfkleresgetre.veqlaytaWPdhGvP..attkellefrkevlkl.tekktkaplvihCsaGvGrtGtyia

MLECIAQINEE-DAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSA
.   . ....|   .|| ..|. ||.||. .|||   |.|||  . ..|. 
lDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 336-578 1.2e-48 160.5 In-house 12-265 (270) alignment 
Range on Protein: 336-578
Range on HMM: 12-265/270.0
TQTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVK---GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLND-DNKRDKSCARYWS
..  . . ..   |||. ||  . ||.|.. .  | . ..|| .|.   |.. ..|... |.|.|. .|| |... . ..|||. .  .|  | |.|||.
sdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

DKGVK----TFGPVSVTTLSISERRGFIEREIEVTqNKPKARHVVkQYQFVDWPTKA----EERKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVG
 .  .    ..| ..|..|| . ..|.| ...... .| . |..|  .....|| ..    |... ..  ||... .|  | .  ... |.|||| .|||
aepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
|||.. ..  ..  ..|.  ||| .... ||..|| .||. | |.|.|. . || .
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 331-575 1.7e-48 159.9 In-house 20-264 (283) alignment 
Range on Protein: 331-575
Range on HMM: 20-264/283.0
CTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSsdsDFVNASFVK-----GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLND-DNKRDKS
  .|... |.  ||. | |. . .|....|| |.|      |..||.|.       .  ..| .| |. .|| ||| || | . ..||||    .  .. 
vpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CARYWSDKGVKTFGPVSVTTLSISERRGFIEREIEVTQN-KPKARHVVKQYQFVDWptkaEERKDHAPylLNLM---TEVEdSFSGVAEGFPVLVHCLNG
|..||  .| . .|.  ||       . || .|. . .|   |.  ..  ||..||     |  . |.  .| .     |  |     .  |..||| .|
CsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqai..inslvkfnkvi.slqteskkgPivvhCstg

VGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINE
.|||.||...   . ..  |  ||||..||..|..||  ||| . | .|.||. |
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN13_pd Subfamily PTPN13 333-577 1.7e-48 160.3 In-house 25-269 (273) alignment 
Range on Protein: 333-577
Range on HMM: 25-269/273.0
PL-STQTATKTENRSKSRYANSLPMERNRVILQSRGSsdsdFVNASFVK----GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCA
|| ..... | ||..| || | ||... ||.|.. |.    ..|||..|     ..|..| .| |.|.||.||| || . . . |.|.  .  ..|  | 
pldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

RYWSDKG---VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKdhAPYLLNLMTEVEDsFSGvaEGFPVLVHCLNGVGR
||| ..    .|  . . |. | . .. ||  |...|.... .. . | . .||.||     ..  |  ||....||   .    .  |..|||  |.||
rywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrr.lqt..dagPivvhcsaGiGr

TGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
.|.. |.   .  |. .  .|| ..|. ||. |   |||.. | |||. | | |
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 66-298 1.1e-45 150.7 In-house 31-274 (287) alignment 
Range on Protein: 66-298
Range on HMM: 31-274/287.0
TVAEKKVNFEKNRYKNILPYDSSRVRLAITNdDPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPES
  ||.  . .|||| ..||.| .|| |. .  .  ||| || |..  .   . ..   |  |.. ||||.|..... .....|.  | .. || .|||| 
kaaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

TS-VNF-GDIVVVLSSVASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVK-----KDHGQNSSPLLVHCSAGVGRTGVLLS
   .   |  ||.|.          |.| |   .. ..|||.|... .||||... ..  | ... .||     .  ...  ||.||...|.||.|.||.
evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVL
.  .|   . . .||.   | ..|. |  .||.  |....| |. 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 443-584 2.5e-45 149.5 In-house 253-392 (392) alignment 
Range on Protein: 443-584
Range on HMM: 253-392/392.0
TTLSISERRGFIEREIEVTQNkPKARHVVKQYQFVDWPTKAEERKDHAPYLLNLMTEVEDSFSGVAEgFPVLVHCLNGVGRTGVFCTMLECIAQINEEDA
..|| |       . . ....  || | | ||||  || .  ...  |  || |.  |  |     | | .||||| | |||||||| .|||||| | |.
qdlstssdGdvrskqlkefrs.lkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskke.fsilvhclsgagrtgvfctameciaqiaegds

VDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEYEQ
||.|| ||.|| .|| ||||||.|||||..|.||| ...|||
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 332-581 5.6e-45 148.3 In-house 28-297 (301) alignment 
Range on Protein: 332-581
Range on HMM: 28-297/301.0
TPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS---SDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSC
.. |..  .. ||.  .|. |  ... ||.||.   .   .  ...|||...| .   .|| .| || .|..||| ......|..|||. . ...  ..|
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

ARYWSD--KGVKTFGPVSVTTLSIS-----------------ERRGFIEREIEVTQNKpkARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDSFSG
 .||..  .  ..|||..||  .                      |.|||...|...|  . . | |.| .|||.    |  .    |. . .|      
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt..vLqviddvihrqqk

VaEGFPVLVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANE
. .| ||.||| ..|.|.||.|..   . |   |  |||||..| .|  ..  |.| | | ..|. |..||. |.
i.gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 43-304 1.2e-44 147.3 In-house 10-296 (301) alignment 
Range on Protein: 43-304
Range on HMM: 10-296/301.0
KNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITN--DDPNSDYFNASYIPVNKE---SVSKTRPNNASMDDFWRMVWQEN
 . |.. | |..  | ...  . ||  .. | . ||.||| .||  |. |. ..  |  . .| |||||   .|    .    | .  . ||||..||| 
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

VNTIAMVTKLQEGTKIKCRQYWPEST--SVNFGDIVVVLSSVA-----------------SCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAV-PNSTS
. .| |||.|.|||| ||.||||.|.  | .|| . | |.. .                 |  | ..|..  ..  ... | |.. |.||.  | ..   
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

TLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSE
 ||     ... .  . .|..||||..|.|.||  |..  .  .|.   ||.|. .  .|...| .|.| ||| ..| .. . |  .
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 329-580 2e-44 146.5 In-house 23-280 (287) alignment 
Range on Protein: 329-580
Range on HMM: 23-280/287.0
RRCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVML-NDDNKRDKSC
 . ...  ..|... . .| |||. ||.. .||.|   |   ||..|| .| . .   .||..| |.. || ||| .|.. . ......  . ..  . |
sesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

ARYWSDKGVK-TFGPVSVTTLSISERR-GFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERK--DHAPYLLNLMTEVEDSFSGVAEGfPVLVHCLNGV
 .|| .. |    |  ||. |. . .   .  | . . . . .  .||||.....|| |.        . . |.    .| . ..   | |..||.  |.
ykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG.PlvvhddvGi

GRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSAN
||.|.. ..| .. . ..   ||| ..|  ||. |  .||.   . ..|| .  |  .|
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_PTPN14_pd Subfamily PTPN14 333-578 1.3e-43 144.2 In-house 38-297 (300) alignment 
Range on Protein: 333-578
Range on HMM: 38-297/300.0
PLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSSDSDFVNASFVK----GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDN-KRDKSCAR
   ..||.  || .|.|. . || | ||| |..   ......||| .|    |... .|..| |...|| ||| || . . . |||| ... .  . . .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWSDKG----VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKA--EERKDHAPYLLNL---MTEVEDSFSGVAEGFPVLVHCL
|. ...      .||   |||   ..   .| . ...     | .  |   |..||| .   |. |.   || ..     ..... ..  .  ||||||.
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

NGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
.|||||||  .    || .. .. .|. .....||. ||..|||   | |||... .|| 
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0041856 (Phosphotyrosine protein) phosphatases II 73-307 1.3e-41 137.6 In-house 1-177 (182) alignment 
Range on Protein: 73-307
Range on HMM: 1-177/182.0
NFEKNRYKNILPYDSSRvrlaitnddpNSDYFNASYIPVNKES---VSKTRPNNASMDDFWRMVWQENVNTIAMVTklqegtkikCRQYWPESTsvnfgd
|..||||..||||| ||          ..|| ||...  .  .   .   .| . .. ||.||.......|| ..|         ...||||        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

ivvvlssvasccgglkrtlsltkgakTRVVNQFHFTEWPDKAVPNsTSTLQKYISEVKKdhgqNSSPLLVHCSAGVGRTGVLLSIDSVVAEakrtkEVDI
                          .| . |.... |||  ||. ...| ..| ||..    .. | ||||||||||||.|  .. .        .|..
..........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

FGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTR
.  |  .|. || ||.| .||.|.. |.|| ||  .||
eeavklvrsrRpgmvitpnqyfflqlallellllkktr
0051429 (Phosphotyrosine protein) phosphatases II 100-322 2e-41 137.8 In-house 3-245 (272) alignment 
Range on Protein: 100-322
Range on HMM: 3-245/272.0
NSDYFNASYIPVNkesVSKTRPN---------NASMDDFWRMvWQENVNTIAMVTKLQEGTKIKCRQYWP------------ESTSVNFGDIVVVLSSVA
 |.|.||.... .    ....|.         ... .||||. ......|| ..... |  . || .|||            . .....|...| | |. 
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

SCCGGLKRTLSLT---KGAKTRVVNQFHFTEWPDKAVPNSTstLQKYISEVKKdhgqnSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVD-------
 .   . |.| ||   .  ..| | ..|.| |||  || ..  | . .... .     . |.|||||||..|||..  .. ...   ..  ||       
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAlLSEDTRIQASYFESTLMHLQE
 ....| ..|. ||..||| |||.|.| |.||. | . . ..|.|....| ...|
yleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 52-298 3.9e-40 132.3 In-house 31-280 (290) alignment 
Range on Protein: 52-298
Range on HMM: 31-280/290.0
EEFL----CLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVrlaITNDDPNSDYFNASYIPVNKESVSKTR-PNNASMDDFWRMVWQENVNTIAMVTK
 |.|        .. . . . .|  .|.|||||..   | .||   | .|  . ||  | |.   |     |. . .... |.|||| ||.| .| |. .
keyleklkpylpvqylerkifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlce

LQEGTKIKCRQYWPEST--SVNFGDIVVVLSSVA-SCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGqnssPLLVHC
| |  | || ||.||     . ||.| |. |          |.|||.   .  |  ... ..   ||||.|..|| .| . .  ..|  |    |. |||
liedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhc

SAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVL
|||.|||| . .|.  .      ||.|. . |  .|. |   ||   ||  .  ..|
saGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_PTPN1_pd Subfamily PTPN1 321-573 1.6e-39 130.3 In-house 9-267 (290) alignment 
Range on Protein: 321-573
Range on HMM: 9-267/290.0
QEVTINNKRRCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSrgsSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD
.|.  . .. .. ..|..| . |||.. || .  | .  |..|..   .| |..|||.|. ..   ..| || |.||||. || || . .  ..||||  
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

-NKRDKSCARYWSDKG---VKTFG--PVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERkdHAPYLLNLMTEVEDSFSGVAEGFP
 .|.   ||.||  .      ..    ..|. .|  ... .. | .|... | .  ... .. .. ||  .  .     ..|... .| .| | . .  |
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpe..spaaflkflfkvresGslssdvGp

VLVHCLNGVGRTGVFCTMLECIAQINEEDA---VDVFQMVKMLRNERMHFVQTEEDYAFVYELI
...||  |.||.| || .  |...|...|    ||. ...  ||. |. ..|| .   | |  |
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 49-303 5.1e-39 129.1 In-house 17-279 (307) alignment 
Range on Protein: 49-303
Range on HMM: 17-279/307.0
VFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVrlAITNDDPNSDYFNASYIPVN---KESVSKTRPNNASMDDFWRMVWQENVNTIAMVT
 . .||  | | .    ||   . | .||||...   | .|.   .. |   |||  | |. .    |  .    | .... .|| |. ||.|... |. 
alvdefrvlakktpegvtveafsantdknryqdvkcqdkgri..vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlc

KLQEGTKIKCRQYWPES--TSVNFGDIVVVLSSVASCCGGL--------KRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDhgqnSS
|. | .||||.||||        ||.    .|     .. |          || .  . |.| .... ...|||. ||.   |    .. |. |      
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tn

PLLVHCSAGVGRTGVLLSIDSVVAEAKRTKE-VDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
|..|||||||||.| ...|  |     . ..  |.   | ..|..|.| .||. || ...  .|| .| 
pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
0051429 (Phosphotyrosine protein) phosphatases II 371-577 2.9e-38 127.5 In-house 4-225 (272) alignment 
Range on Protein: 371-577
Range on HMM: 4-225/272.0
SDFVNASFVKGNrYR------FITTQMPMPNTVADFWAMvIDYQPSTIVMLNDDNKRDKS-CARYWS------------DKGVKTFGPVSVTTLSISERR
|. .||..|.|. .|      .. ...|.|.|.||||..  ... .|||.| ... |..  | |||             .    ..| ..||.||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GFIEREIEVTQN-KPKARHVVKQYQFVDWPTKAEERKDhapyLLNLMTEVEDsfsgvaeGFPVLVHCLNGVGRTGVFCTMLECIAQINEEDAVD------
 .| ||...|   .... . | .... |||.    ..     ||.|. .. |       | ||||||  |..|||... .| .......|. ||      
dyilrellltlllsagearevmhlhytdwpdhgvpqea....llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
  ... |..||  |...||||| |.|.|| . |.|
lyleeaveelraqrpgavqteeqylflyeallell
0041856 (Phosphotyrosine protein) phosphatases II 344-581 3.9e-38 126.2 In-house 1-175 (182) alignment 
Range on Protein: 344-581
Range on HMM: 1-175/182.0
NRSKSRYANSLPMERNRvilqsrgssDSDFVNASFVKGNRYR--FITTQMPMPNTVADFWAMVIDYQPSTIVMLNddnkrdksCARYWSDKGvktfgpvs
|..| || . ||....|         |.|..||... |...   || || |...|||||. |. ... .|||.|.        . .|| ..         
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell........

vttlsiserrgfiereievtqnkpkaRHVVKQYQFVDWPTKAEERkdhAPYLLNLMTEVEDsfsgvaEGFPVLVHCLNGVGRTGVFCTMLECIAQineed
                           . . ||... ||          . ||... ||..      || ||||||  ||||||... .  .. .     
..........................erlgiqylylpwpDhgvpd...ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.....

AVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANE
 |.... ||..|. |.. |.|.. | |.. .. |.|  ..
gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0036282 (Phosphotyrosine protein) phosphatases II 101-294 4e-38 126.2 In-house 2-163 (174) alignment 
Range on Protein: 101-294
Range on HMM: 2-163/174.0
SDYFNASYIPVNKESVSKTRPN---NasmddFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEstsvnfgdivvvlssvasccgglkrtlslTKGAKTR
|||.|||.. ..  .    . .   .     ||.|.......|. |.....|  . || .||||                             ..   .|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredler

VVNQFHFTEWPDKAVPNSTStLQKYISEVKKDHGQ-NSSPLLVHCSAGVGRTGVLLSIDSVVAEAKrTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVY
 . |.... |||  ||...  |.. ...|.. . . .. |.||||||||||||.|  .. .    . .. ||.. .| ..|. ||.|||| .||.|.|
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0049772 (Phosphotyrosine protein) phosphatases II 333-578 1.1e-37 125.9 In-house 35-281 (314) alignment 
Range on Protein: 333-578
Range on HMM: 35-281/314.0
PLSTQTATKTENRSKSRYANSLPMErNRVILQSRGSSDSDFVNASFVKGNrYRFITTQMPMPNTVADF----------WAMVI--DYQPSTIVM------
.|.. .| . .||.| || . ||.. |||||.. . |.||. |||.|.|   .|| || |...|| ||          | ||.  |... .|||      
eltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LNDDNKRDkscaRYWSDKGVKTFGpvsvttlsiserrgfiereiEVTQNKPKARHVVKQYQFVDWPTKAEERKDHAPYLLNLMTE
               |..   .      ... . ....                     |.. ....  . . .|  ...|   .   .. . .|... |
adelsrLdaAlgKtpllildgng....neptaadlellk....................eelydpelferlgikylripvpDgsaplledfdeflefiee

VedsfsgvAEGFPVLVHCLNGVGRTG--VFCTMLECIAQINEEDAVDVFQMVKMlRNERMHFVQTEEDYAFVYELINEYLS
.        .| ||||||  |.||||  |.. .|    ... |.|.. ...  .  | ...|... |.| |..| ..|||.
a.......dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylk
0046846 (Phosphotyrosine protein) phosphatases II 91-299 2.5e-37 123.7 In-house 2-171 (176) alignment 
Range on Protein: 91-299
Range on HMM: 2-171/176.0
RLAITNDDPNSDYFNASYIPVNKeSVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFgdivvvlssvasccgglkrtlsl
|| .. .|...|| ||..|  ..  . .  | . .. ||..|......... ..|...|  ..|| .|||| .....                       
rlrllgldldldyinanlilgsr.piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tkgaktrvvnQFHFTEWPDKAVPNStSTLQKYISEVKKDHGQNsSPLLVHCSAGVGRTGVLLSIDSVVAEakrtKEVDIFGYVTKIRQNRP-YMVQTKEQ
          |.... |||  ||.. . |.. . ....   ..  | |||||||.||||.|. .. .  |    | ....  . ..|. || ..||| ||
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele....kglsveealalvreqRplgavqtpeQ

YQFVYVAVLE
|.|.| ..|.
yrflyefell
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 384-574 9.2e-37 121.4 In-house 236-435 (440) alignment 
Range on Protein: 384-574
Range on HMM: 236-435/440.0
YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNkrDKSCARYWSDK-GVKTFGPVSVTTLSISERRGFIEREIEVTQNkpKARHVVKQYQFVDWPTK
  ||.||||.  || ||| .| ||. |||.|||. |  ||.|. ||  .    |||| .|      .      | .|.  .  .  | ..|..   ||| 
nafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk..eevheirqfevqtwptw

AE--------ERKDHAPYLLNLMT--EVEDS--FSGVAEGFPVLVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVY
 .        .  |    |.. .   |.. |   |   .| |.||||| |.  .|||||...|. |.|.. |.|||| ...||  |  || |  || ..|
iqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcy

ELIN
 |. 
kllt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 343-574 3.5e-36 119.6 In-house 2-236 (237) alignment 
Range on Protein: 343-574
Range on HMM: 2-236/237.0
ENRSKSRYANSLPMERNRVILQSRGSSdSDFVNASFVK---GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWSDK-GVKTF
||. |.||.|   .. .||.|.  ||. ||..||...|   |   ..|..| |. ..  ||| || . . | ||||    .. .. | .|| .    ...
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPVSVTTLSISERRGFIEREIEVT-QNKPKARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGRTGVFCTMLECIAQ
| ..|.     |   .  | . .. . . |   ...||||  || .   ..  |  || .  .. .    |.|  | ..||  ||||||.|  .   . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

INEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELIN
 .|.  ||... |. . ..| . .||...| |... | 
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 46-299 5.5e-36 118.7 In-house 9-267 (281) alignment 
Range on Protein: 46-299
Range on HMM: 9-267/281.0
HTDVFYEEFLCLPKANIF-PQTVAEKKVNFEKNRYKNILPYDSSRVRLAIT-NDDPNSDYFNASYI--PVNKES-VSKTRPNNASMDDFWRMVWQENVNT
  | | .||  ||        || .. || .|||| ||   | |||.| .   .   .||  | ||  |. |   .    |.. .  |||||.||||  .
tlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentta

IAMVTKLQEGTKIKCRQYWPEST--SVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKkdhgQNSSPLL
| |. .. |  . || .|.|  .   ..|  . |     .     .   | |.   .||.. .. . ||||  ||.|.  . | . ...      |.| .
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir....arstppv

VHCSAGVGRTGVLLSIDSVVAEAKR-TKEVDIFGYVTKIRQ-NRPYMVQTKEQYQFVYVAVLE
.||||||||.| |....  .   .      ||   |...|   |   ||| .|| ...  .|.
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0049260 (Phosphotyrosine protein) phosphatases II 120-294 5.7e-36 118.8 In-house 16-143 (152) alignment 
Range on Protein: 120-294
Range on HMM: 16-143/152.0
RPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWpestsvnfgdivvvlssvasccgglkrtlsltkgaktrvvnQFHFTEWPDKAVPNSTSTL
 | . ...|||||... ...|| |.|.|.| .|.|| ||.                                         |.... |||  ||...  |
gpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwpDhgvpdlsqll

QKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVaeakrtKEVDIFGYVTKIRQNRPYMVQTKEQYQFVY
.  .  ..|   ... | ||||||||||||.|  .. .       . |... .|  .|. ||..|....|..|.|
lflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPRN_pd Subfamily PTPRN 330-575 2.7e-35 116.5 In-house 42-290 (297) alignment 
Range on Protein: 330-575
Range on HMM: 42-290/297.0
RCTPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGS-SDSDFVNASFVKGNRYR---FITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNK-RDKS
.  | ....| . .| .| |... || . .|| |... | ..||..|||..  .  |   .|.|| |...|||||| || .     ||.|   ..   | 
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

CARYWSDKGVKTFGPVSVTTLSIS-ERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERkdHAPYLLNLMTEVEDSFSGvaEGFPVLVHCLNGVGR
|.||| |.| ....   |  .|       .. | . . . . .    | |. |. || ..      |  ||..   |. |. |     |..||| .|.||
ckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPa..saksllefrrkvnksyrG..rscpivvhcsdGaGr

TGVFCTMLECIAQINE-EDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINE
|||.. .   .....     .|.   .. ||..| ..|.|.... |..  . |
tGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0049772 (Phosphotyrosine protein) phosphatases II 66-301 1.8e-34 115.3 In-house 39-280 (314) alignment 
Range on Protein: 66-301
Range on HMM: 39-280/314.0
TVAEKKVNFEKNRYKNILPYDsSRVRLaITNDDPNSDYFNASYIPVNKESVSKTRPNNASMDDF----------WRMV--WQENVNTIAM----------
.|| . .| .||||..|||.| .||.|  . .  .|||.||||.   .  . .  |..  ..||          ||||  .. || .| |          
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------VTKLQEGTkikcrqywPESTSVNFGDIVvvlssvasccgglkrtlS--LTKGAKTRVVNQFHFTEWPDKAVPnSTSTLQKYISEVKKDh
            ..| ...        .| |  .. ..                  .    .   .| . ... . .||  .| ... ... .  ...  
srLdaAlgKtpllildgng........neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea.

gQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRtKEVDIFGYvtkIRQNRP-----YMVQTKEQYQFVYVAVLEAL
 .. .|.||||.||.||||... .. ..   .     ... .   .|. ||      .... |||.|.. |.||.|
.dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealed...vrlkRpinpnpgfieqleqyefilealleyl
0043147 (Phosphotyrosine protein) phosphatases II 98-294 2.6e-34 113.8 In-house 2-154 (172) alignment 
Range on Protein: 98-294
Range on HMM: 2-154/172.0
DPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLqegtkikcrqywpestsvnfgdivvvlssvasccgglkrtlSLTKGA
|..||| ||||....    . .    | .  ..|||||........| ..|.|                                          ...  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpel

KTRVVNQFHFTEWPDKAVPnSTSTLQKYISEVKK-DHGQNSSPLLVHCSAGVGRTGVLLSIDSVVaeakrtKEVDIFGYVTKIRQNRPYMVQTKEQYQFV
 .| . |.... |||  || ... |.. .. ...  . ... | ||||||||||||.|  .. .       . ....  |  .|. ||..||...||.|.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

Y
|
y
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 189-311 5.7e-34 112.2 In-house 81-204 (440) alignment 
Range on Protein: 189-311
Range on HMM: 81-204/440.0
SLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQ-NSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTK
|  .| ..|...|.|.  ||||.||. .. . | | .|.. . .  ..|||||||||.|||||....||.. ||||. ..||| ..  .|.||| |||| 
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

EQYQFVYVAVLEALLSEDTRIQAS
||| ||. ||||.||. || |   
eqyafvheavlegllcgdtliled
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 343-582 8.9e-34 111.4 In-house 55-288 (290) alignment 
Range on Protein: 343-582
Range on HMM: 55-288/290.0
ENRSKSRYANSLPMERNRVILQSrgSSDSDFVNASFVKGNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD--NKRDKsCARYWSDKG--VKTFG
 .  | || .    .. ||||.     | |.| | .||| .  || || .. .|| |.| ||.. . ..|||| .   . . | |..|. .|   | |||
tefkknrykdvvcndktrvilkd..GydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkak.ceqyypekeGevltfG

PVSVT-TLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDsFSGvaegfPVLVHCLNGVGRTGVFCTMLECIAQI
 ..|. ... ..    | . . | . .    |..| .. . || |.    . |  || ..  .    ||     || |||  |.|||| | ..  ..  .
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla..llrtlrilrk.asG.....pvvvhcsaGiGrtGtfvaievglqil

NEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEY
 .  ..|. ..|. ||| |.  || . .|  . |.. ..  ...|
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 70-303 4.6e-33 109.2 In-house 52-291 (305) alignment 
Range on Protein: 70-303
Range on HMM: 52-291/305.0
KKVNFEKNRYKNILPYDSSRVRLAITNddpNSDYFNASYIPV----NKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTS-
 ...  ||||...   | | |.|.  .    |||  | |. .    .|  .    | . ..|.|| || |..|. | |. |  |  |.|| |||| .   
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

---VNFGDIVVVLSSVASC--CGGLK-RTLSLTK-GAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKkdhGqNSSPLLVHCSAGVGRTGVLLSIDSV
   .. | .|  .|          ..  .| ||  | ..  | ....|||||. ||    |  . .| ..   |    |..||||||.|||| ...|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...g.skvpivvhcsagigrtgtivaieyi

VAEAKRTKEVD-IFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
. .    |..  .   |  .|..| . .|.  || |..  .|. .| 
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 339-577 4.8e-33 109.3 In-house 23-259 (267) alignment 
Range on Protein: 339-577
Range on HMM: 23-259/267.0
A-----TKTENRSKSRYANSLPMERNRVILQSrgsSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKrdKSCARYWSD
.       ..|. . |. ..|| . .||||.    .. ...|||.|.| .    || || |. ||..||. ...|.. ..||.|    .      ..|  
stisqsiaeknqernrlddnlpyddtrvilrt...keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft..dnirlfwPP

K--GVKTFGPVSVTTLSISERRGFIEREIEVTqNKPKARHVVKQYQFVDWPTKAEERkdhaPYLLNLMTEVEDSFsGVAEGFPVLVHCLNGVGRTGVFCT
|    | .  ..|      |   .    .|.   | .. | |  | .  |  .....    |||  |.  .         . |..|.| .||||.| | .
kmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkwnintnnk....pylkplfgilaknq.lengnrPlvvacsdGvGrsGtflv

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
.   . .. .|. .|.|.... .|. |. .|.| | | ...||. || 
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 338-570 5.6e-33 109.1 In-house 2-234 (239) alignment 
Range on Protein: 338-570
Range on HMM: 2-234/239.0
TATKTENRSKSRYANSLPMERNRVILQSRG-SSDSDFVNASFVK---GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD-NKRDKSCARYWSDK
.| |  |..| |||| .  ...||.|.       ||..|||...   |.   .|.||  .  .  ||| |. . .   ||||    . . | | .|| | 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GVKtFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERkdHAPYLLNLMTEV-EDSFSGVAegfPVLVHCLNGVGRTGVFCTML
  | .  . ||         .| | . ..|      . | ||.|  || |   .  .|  .| |  .. .||. |     | ..||  |||||| |  . 
tsk.ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq..yatavlglrrkitkdslpgar...pwvihcsagvgrtgaflvid

ECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVY
  . | ... .||.|. || .|..| |.||| |.| |..
amlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 339-571 7.3e-33 108.7 In-house 2-234 (239) alignment 
Range on Protein: 339-571
Range on HMM: 2-234/239.0
ATKTENRSKSRYANSLPMERNRVILQSRG-SSDSDFVNASFVK---GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD-NKRDKSCARYWSDKG
| |  |..| |||| .  ...||.|.       ||..|||...   |.   .|.||  .  .  ||| |. . .   ||||    . . | | .|| |  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

VKtFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERkdHAPYLLNLMTEV-EDSFSGVAegfPVLVHCLNGVGRTGVFCTMLE
 | .  . ||         .| | . ..|      . | ||.|  || |   .  .|  .| |  .. .||. |     | ..||  |||||| |  .  
sk.ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq..yatavlglrrkitkdslpgar...pwvihcsagvgrtgaflvida

CIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYE
 . | ... .||.|. || .|..| |.||| |.| |.. 
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
PTPc_DSPc_SM00012 199-299 8.5e-33 108.1 In-house 2-105 (105) alignment 
Range on Protein: 199-299
Range on HMM: 2-105/105.0
VNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNS--SPLLVHCSAGVGRTGVLLSIDSVVAEAKRT-KEVDIFGYVTKIRQNRPYMVQTKEQYQFVYV
|...|.|.|||. ||.... . ... .||| . ...  .|..|||||||||||..  .| ..   ... |||||| .| ..|. || ||||.|||.|.| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 339-577 7.6e-32 105.3 In-house 43-279 (439) alignment 
Range on Protein: 339-577
Range on HMM: 43-279/439.0
ATKTENRSKSRYANSLPMERNRVILQ-SRGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKscarYWSDKGVK
|..  ...| || .  ...  ||.||   |   | ..|| ..||      .|.||.|  .|. ||| .||. . .||||| .  .  |    ||  ..  
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaev

TFGPVSVTTLSISERRGFIEREIEVTQNKP--KARHVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEdSFSGVAEGFPVLVHCLNGVGRTGVFCTMLEC
 .| ..| .    |   .. | . | ...   .  . | |.... || |      .| ..|...  .. |     |  ||.|||  ||||||   ..  .
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknv..paqashvldflrain.sandkeeygpvvvhcsagvGrtGtiialdia

IAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
. |.. |. ||.  .||.||..| ..||.  .| |.|. . | .
leqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_ptpA1_pd Subfamily ptpA1 67-252 2.3e-31 104.0 In-house 41-247 (418) alignment 
Range on Protein: 67-252
Range on HMM: 41-247/418.0
VAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIP--VNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTS
  .|| |  |||| |||| . .||.|   .|   ||| || ||     |. .    |   .. |||||||.. .  | |...  |  .||| .||||   
egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

V-----------NFGDIVVVLSSVASCC--GGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQ------NSSPLLVHCSAGV
             ||   | |  |        . | . ||   .|| . |...  |||. .|. |  ... .  . . . |         |..|||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGVLL
|||| . 
grtgtfc
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 67-225 4.1e-31 102.9 In-house 27-192 (297) alignment 
Range on Protein: 67-225
Range on HMM: 27-192/297.0
VAEKKVNFEKNRYKNILPYDSSRVRLAitNDDPNSDYFNASYIPVNKES-----VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPE
.| ..  . ||||..|| .|..||.|   .  ...|| || |.   .|      .    | .|..||||..|....|..|.||.||||. . ||  |||.
sakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

STSV--NFGDIVVV-LSSVASCCGGLK-RTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISE
.     . ||.||  |||..     ..   | |   ...|||.   |  |||. ||.    |... ..
vvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
0044763 (Phosphotyrosine protein) phosphatases II 84-296 1.1e-30 102.0 In-house 1-166 (178) alignment 
Range on Protein: 84-296
Range on HMM: 1-166/178.0
PYDSSRVRLAITNDDPNSDYFNASYIPVNkESVSKTRPnnasmDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSvnfgdivvvlssvasccgg
|.| .|| |    . . |||.|||.|  .   ..   |      |............| ..|. .|. ..|| .||||...                   
pldrtrvllsnleglersdyinaseilpg.lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...................

lkrtlsltkgaktrvvNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEakrtkEVDIFGYVTKIRQNRPyM
                 |.... .||  ||.... ... .  ... . .. .| ||||||||||.|.|  .. .         ....  .  .|. || .
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.i

VQTKEQYQFVYVA
|.. .|....|  
vpnpgqlrqLyef
0036282 (Phosphotyrosine protein) phosphatases II 371-571 2.8e-30 100.7 In-house 2-164 (174) alignment 
Range on Protein: 371-571
Range on HMM: 2-164/174.0
SDFVNASFVKGNRY--RFITTQMPMPntvadFWAMVIDYQPSTIVMLNDDNKRD-KSCARYWSDkgvktfgpvsvttlsiserrgfiereievtqNKPKA
||. |||......   |.| .| |..     ||.|. ... .|.|||.. . ..   | .||..                               ..   
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

RHVVKQYQFVDWPTKAEERKDHapyLLNLMTEVEDSFSGvAEGFPVLVHCLNGVGRTGVFCTMLECIAQINeEDAVDVFQMVKMLRNERMHFVQTEEDYA
.. . ||... ||   .   .    ||... .||. .|   .| ||||||  ||||||... .. .. ..  |..||....|..||. |.. |||.. | 
erlgiqylylpwpDhgvpdlsi...llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FVYE
|.|.
flyy
0046846 (Phosphotyrosine protein) phosphatases II 367-577 3.3e-30 100.5 In-house 8-173 (176) alignment 
Range on Protein: 367-577
Range on HMM: 8-173/176.0
GSSDSDFVNASFVKGNryRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDN-KRDKSCARYWSDkgVKTFGPvsvttlsiserrgfiereievtqnkp
   |.|..||... |.  |.|.|| |.|.|.|||..|. ... ...|.|...  .   .|..||..  ....|                           
ldldldyinanlilgs..rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

karhvvkQYQFVDWPTKAEERKdhaPYLLNLMTEVEDSFSGvaeGFPVLVHCLNGVGRTGVFCTMLeciaQINEEDAVDVFQMVKMLRNERM-HFVQTEE
       ||....||           .||.|. ....  .    | ||||||  |.||||... ..     .  |  ..|.. ....|. |. . |||.|
.......qylhlpwpDhgvpdl...elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

DYAFVYELINEYL
 | |.|| . ..|
Qyrflyefellll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 50-301 9.8e-30 98.3 In-house 24-287 (305) alignment 
Range on Protein: 50-301
Range on HMM: 24-287/305.0
FYEEFLCLPKANIFPQTVAEKKV-NFEKNRYKNILPYDSSRVRLaitNDDPNSDYFNASYI--PVN-KESVSKTRPNNASMDDFWRMVWQENVNTIAMVT
. .|| .. . | | .  | |.  . .|||||..   |  ||.|   .     .|  | |.  | | |  .    | . .  ||| | .|..|..| |. 
lraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc

KLQEGTKIKCRQYWPES--TSVNFGD----IVVVLSS-V-----ASCCGGLKRTLSLT--KGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHG
.|.|    || .|..      ..| .    |.| . | |     ...   ...|  .    |.|.| |...|. .|||. || .  .. . . . .  .|
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg

qnssPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIF-GYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
    |. ||||||.|||| .. .. .. .    . ..     . |||..|   .|| .|| ||.  .|. .
....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 67-297 9.8e-30 98.4 In-house 29-255 (267) alignment 
Range on Protein: 67-297
Range on HMM: 29-255/267.0
VAEKkvNFEKNRYKNILPYDSSRVRLAITNDDpnsdYFNASYIPVNKES---VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGtkiKCRQYWPES-
.|||  | |.||. . |||| .|| |  ....    | ||||.   |     .    | . .. ||. .. ...| .| ..||  ..   . |..||   
iaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkm

-TSVNFGDIVVVLSSVASCCGGLKRTLSLT-KGAKTRVVNQFHFTEWPDKAvpNSTSTLQKYISEVKKDHGQN-SSPLLVHCSAGVGRTGVLLSIDSVVA
  . .. |..|  |           || |  |   .. |  ... .|  ..  |    |.  .  . |.. .| . ||.|.||.||||.| .| ||| . 
gqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqle

EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAV
 ||.   .||| .. |||. |. .|.|||.| ...  .
raktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_ptpA1_pd Subfamily ptpA1 331-532 2.4e-29 97.3 In-house 34-251 (418) alignment 
Range on Protein: 331-532
Range on HMM: 34-251/418.0
CTPLSTQTATKTENRSKSRYANSLPMERNRVILQS-RGSSDSDFVNASFVKGNR-YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCAR
  |  |    |  | || ||.| ||... || |.  .    ||..|| .. |    .|| || |.|||.|||| || . .   ||||. ...     | |
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWSDK-----------GVKTFGPVSVTTLSIS--ERRGFIEREIEVTQNKpKARHvVKQYQFVDWPTKAEerKDHA---PYLLNLMTEVEDSF-SGVAEG
|| ..           | . ||  ||  . .     |  | |.| .| .  ..|  . |||.  || .     ||.     ||  .|. ..         
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg.etrd.itqyqyegwpdhni..pdhtqpfrqllhsitnrqnqiipssdrn

FPVLVHCLNGVGRTGVFCTMLE
 |..|||  |||||| ||| . 
vpiivhcsagvgrtgtfctavi
0043147 (Phosphotyrosine protein) phosphatases II 369-571 9e-29 95.8 In-house 3-155 (172) alignment 
Range on Protein: 369-571
Range on HMM: 3-155/172.0
SDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDnkrdkscarywsdkgvktfgpvsvttlsiserrgfiereievTQNKPK
..||..|||......   ||| || |..||.||||.|. ... ..||.|..                                           . ....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

ARHVVKQYQFVDWPTKAEErkdHAPYLLNLMTEVEDSFsGVAEGFPVLVHCLNGVGRTGVFCTMLECIaqineeDAVDVFQMVKMLRNERMHFVQTEEDY
  . . ||... ||        .. .||...  ... .  . .| ||||||  ||||||... .. ..        ..... |...|. |.. ||... |
lerlgiqylylpwpDhgvp...llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

AFVYE
 |.|.
rflyy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 73-303 1.6e-28 94.6 In-house 43-273 (288) alignment 
Range on Protein: 73-303
Range on HMM: 43-273/288.0
NFEKNRYKNILPYDSSRVRLAitnDDPNSdYFNASYIPVNKE---SVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST--SVNF
|  ..||.|.   | .||.|    |||.  | .|  .. .|     .    | |. .. .|.|. ...|. | |...| |  | |  .|.|     .. .
nptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDIvvvLSSVASCCGGLKRTLSLT-----KGAKTRV-VNQFHFTEWPDKAVPNSTSTLQKYISEVkkdhGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEA
| .    . |     .........     |  ...| | . |. ||.|..||..  .  . .  .     .   |..||.|||||||| |  |  ..  .
grl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialesl

KRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLS
. .  . |   ..| |..|   .||. || .|.  ||| || 
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0051082 (Phosphotyrosine protein) phosphatases II 101-298 4.2e-28 93.2 In-house 3-150 (151) alignment 
Range on Protein: 101-298
Range on HMM: 3-150/151.0
SDYFNASYIPVNkesvskTR----PnnasMDDFWRMVWQENVNTIAMVTKLQEGTkiKCRQYWPESTsvnfgdivvvlssvasccgglkrtlsltkgakt
|||.|.||.  .            |    ..||..........|| ......|    .| .|.||                                   
sdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

RVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKdhgQNSSPLLVHCSAGVGRTGVLLSIDSVVAEakrtkeVDIFGYVTKIRQNRPYMVQTKEQYQFVYVA
. | ..... |||  .| |. ......... .   ... |.|||||||.||||.|  .. .         |...  .  .|. ||..||...|..|.. |
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

VL
.|
ll
0051082 (Phosphotyrosine protein) phosphatases II 371-572 2e-27 91.1 In-house 3-148 (151) alignment 
Range on Protein: 371-572
Range on HMM: 3-148/151.0
SDFVNASFVKGNryrFITTQMPMPntvaDFWAMVIDYQPSTIVMLNDDNKRDkSCARYWSDKGvktfgpvsvttlsiserrgfiereievtqnkpkarHV
||. |.|.| |.   .. ...|..    ||.... ... .|||.|...  |.  |..|. . |                                   . 
sdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................ie

VKQYQFVDWPTKaeERKDHAPYLLNLMTEVEDsfsgvAEGFPVLVHCLNGVGRTGVFCTMLECIAQineedaVDVFQMVKMLRNERMHFVQTEEDYAFVY
|......|||.      .. . .|... ...|      .. ||||||  |.||||... .. .. .      |.... ....|  |...||... . |..
vlhipildwpdp..glplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EL
  
fa
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 332-596 4e-27 90.0 In-house 29-299 (307) alignment 
Range on Protein: 332-596
Range on HMM: 29-299/307.0
TPLSTQTATKTENRSKSRYANSLPMERNRVILQSRGSSdSDFVNASFVK--GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARY
|| . .. . . |  | || .   ....|....  | . ||.. | ..    .  .|| .| |. ||. .||||.|. .  ...|| .  .  |  | .|
tpegvtveafsantdknryqdvkcqdkgrivvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqy

WSD-KGVK-TFGPvSVTTLSISE----RRGFIEREIEVTQNKP---KARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEdsfsgvAEGFPVLVHCLN
|   .| | .||  .  |.|...    .    |  |.||. |    .    ....|. .|| .   . . .   .||.  |.       .  ||.|||  
wpleegqklvfge.apntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt..ainlleavr......ydtnpvvvhcsa

GVGRTGVFCTMLECIA-QINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS---ANEYEQLPVPVEYEHTYG
||||.|   ..       |. ..  |. ..|. ||..| . .|||  | ... .. ||.     . ||.| .  .||. | 
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekya
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 69-305 5.4e-27 89.5 In-house 31-274 (285) alignment 
Range on Protein: 69-305
Range on HMM: 31-274/285.0
EKKVNFEKNRYKNILPYDSSRVRLaiTNDDpnSDYFNASYIPV--NKES--VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST-
  . | . ||| ..   . .|| |   | |   ||  ||.. .  . .|  ..   |   .. |||.|..||..  . |.  | ||   ||  |.||   
ayeanpdlnryadvrcieetrvvl..knhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

-SVNFGDIVVVLSSV--ASCCGGLKRTLSLTKG--A--KTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQnSSPLLVHCSAGVGRTGVLLSIDS
  |.||   . |. .   . .| .  .|....   |  .   .|. .   |||.  |. .  . .    |||   .   |. ||||||||||  .. || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidy

VVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSED
         .....  | ..|  |   ||.. |. |.|| ..| .. | 
atirimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg
0049260 (Phosphotyrosine protein) phosphatases II 383-571 1.1e-26 88.8 In-house 8-144 (152) alignment 
Range on Protein: 383-571
Range on HMM: 8-144/152.0
RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWsdkgvktfgpvsvttlsiserrgfiereievtqnkpkarhvvkQYQFVDWPT
 ..|| || |.|||.|||| |. ... .|||||...  ..|  |..|.                                           ||... || 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpD

KAEERKDHAPYLLNLMTEVEdsfsGVAEGFPVLVHCLNGVGRTGVFCTMLECIaqineeDAVDVFQMVKMLRNERMHFVQTEEDYAFVYE
      .   . |.|. |         .| ||||||  ||||||... .. ..        |.... |...|. |.. |.... . |.||
hgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 370-576 9.8e-26 85.2 In-house 79-285 (301) alignment 
Range on Protein: 370-576
Range on HMM: 79-285/301.0
DSDFVNASfvkGNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD-NKRDKSCARYWSDKGVKTF--GP--VSVTTLSISERRGFIEREIEVTQNK
 ......|   |.  |||.|| |..||  |||||.. |.  .||||    .|  . |. | . |  ...  |   . ...     .   ..|..||.   
hanwipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedst

PK-ARHVVKQYQFVDWPTKAeERKDHAPyLLNLMTEVEDSFSgvaegfPVLVHCLNGVGRTGVFCTMlECIA-QINEEDAVDVFQMVKMLRNERMHFVQT
 | | . |  ||...|. .    | ||  | .||  | .|        |..||| .|.||.  | .  |..| ... .  ... . .| ||..| . |||
gkfatrtvthyqysewtdrg.vPkshae.lfdlmelvkksek......PivvhcsaGiGrsvafigt.eylareveadptieltealkhlrehrwngvqt

EEDYAF-----VYELINEY
..   .     || ||.||
nsqlywmtlGtvyrlikey
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 383-571 1.9e-25 84.2 In-house 4-198 (199) alignment 
Range on Protein: 383-571
Range on HMM: 4-198/199.0
RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWS--DKGVKTFGPVSVTTLSISERRGFIEREIEVTQNK--PKARHVVKQYQFV
. |.|.|| |. .|.|||| || .     |||.|||.|  .   . ||.  . |.  .| .|||| .|. .  .    . .|.|   | .   . .||| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPTKAEERKDHAPYLLNLMTEVEDSFSGVaEGFPVLVHCLNGVGRTGVFCTMLECIAQINEE--DAVDVFQMVKMLRNERMHFVQTEEDYAFVYE
 |  |.         ..    ||   .       ||.||| .| | |||| ..   .   .|     ||.|.. | ||. |   . . . | |.|.
swkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 384-571 2.2e-25 84.0 In-house 4-197 (198) alignment 
Range on Protein: 384-571
Range on HMM: 4-197/198.0
YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWS--DKGVKTFGPVSVTTLSISERRGFIEREIEVTQNK--PKARHVVKQYQFVD
 |.|.|| |. .|.|||| || .     |||.|||.|  .   . ||.  . |.  .| .|||| .|. .  .    . .|.|   | .   . .|||  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPTKAEERKDHAPYLLNLMTEVEDSFSGVaEGFPVLVHCLNGVGRTGVFCTMLECIAQINEE--DAVDVFQMVKMLRNERMHFVQTEEDYAFVYE
|  |.         ..    ||   .       ||.||| .| | |||| ..   .   .|     ||.|.. | ||. |   . . . | |.|.
wkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
PTPc_DSPc_SM00012 471-574 3e-25 83.8 In-house 2-104 (105) alignment 
Range on Protein: 471-574
Range on HMM: 2-104/105.0
VKQYQFVDWPTKaeerkdH----APYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGRTGVFCTMLECIAQINEE-DAVDVFQMVKMLRNERMHFVQTEED
||.|.. .|| .      .    .  .|.|. .|... .  ... ||.||| .||||||.|...  .. |...| . ||.||.||.||..|.. |||||.
vkhyhytgwpdh......gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq

YAFVYELIN
| |.|. ..
ylflyrall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-306 4e-25 83.2 In-house 30-281 (312) alignment 
Range on Protein: 61-306
Range on HMM: 30-281/312.0
NIFPQTVAEKKVNFE-KNRYKNILPYDSSRVRLAitNDDPnsDYFNASYIP--VNKE-SVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCR
||....     ..|   ||| ||  .|  |  ||   |.    |  | ..    . |  |.   | . .   ||...      .| ... . | .  || 
nivsdsectaflkfkdlnrypniqcwdrgrftla..gden..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekca

QYWPEST-SVNFGDIVVVLSSVASCCGGLKRTLSLTKG---------AKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHgqnsSPLLVHCSAGVG
.|  .    |.. |  |   ...    | |    .|.           .   .|.. .. |||. .|.|  | .. .| ||||.     |.. |||||||
kyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvg

RTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDT
||| |  |.|..|  .  .  ..      .|..|   |..  || ..  .||| | |.  
rtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 343-584 1.4e-24 81.7 In-house 42-278 (288) alignment 
Range on Protein: 343-584
Range on HMM: 42-278/288.0
ENRSKSRYANSLPMERNRVILQsrgsSDSDFVN-ASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLND--DNKRDKSCARYWSDKGVKT-
.| .. || |    .  || |.     |.||   |  |  ..|  |.| .| |.  |.  .| |... .   ||||..  .  ..||   . | .| |. 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGPVsvtTLSISERRGFIEREIEVTQ---NKPKARHV-VKQYQFVDWPTKAEErKDHAPYLlNLMTEVedsfsgVAEGFPVLVHCLNGVGRTGVFCTMLE
.| .      . ..|  |.. ..|.    .|.   .| ||.  . .|. ..   ... ..| .|.. .       .   |..||. .|||||| .  .| 
igrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP.enylspl.rllevl......kslqkPivvhssaGvGrtgtlilili

CIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEYEQ
 . ..  .| . . .... ||.||.. .|||  | .|. .. |.|    |..
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_egg_pd Subfamily egg 64-298 1.6e-24 81.1 In-house 31-267 (307) alignment 
Range on Protein: 64-298
Range on HMM: 31-267/307.0
PQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYI---PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGtkIKCRQYWP
. | | .. | || | | .   |||||.| . .     |.  | ..   |.  | .    |   ..|||||||.||.|. | |.|  .|    .|  |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

ESTS--VNF--GDIVVVLSSVASCCGGLKRTLSLTK-GAKtrvVNQFHFTEWpDKAVPNStSTLQKYIsEVKKDHGQNSSPLLVHCSAGVGRTGVLLSID
 . |  . .  | . .    | |    | |   |   |..    .. .   |    | || | .   . .| .   . | | .|..  || ....|..|.
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehw.qgdvnns.sdvyspl.rvlrklrnlskpvvvqdilGvskaatlvaie

SVVAEAKR--TKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVL
  . .  |  .    .   |  .|..|.. |..  .| |||  ||
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 116-294 1.6e-23 77.9 In-house 8-197 (199) alignment 
Range on Protein: 116-294
Range on HMM: 8-197/199.0
VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP--ESTSVNFGDIVVVLSSVASCCG----GLKRTLSLTKGAKTRVVNQFHFTEWPD
..  .|   .| |||.|||.     | ||   |   .     |||  ||.. ..| . |.  ....        |  | . |    || . .. || | .
iatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswke

KAVPNSTSTLQKYI--SEVKKDHGQN-SSPLLVHCSAGVGRTGVLLSIDSVVA--EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVY
|. || .  .   .   || | . |.  .|..|||| | | |||....|  |   |  .|  ||.|    ..|| |  .. . ..|.|.|
kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 339-579 2.3e-23 77.4 In-house 43-289 (305) alignment 
Range on Protein: 339-579
Range on HMM: 43-289/305.0
ATKTENRSKSRYANSLPMERNRVILqsRGSSDSDFVNASFVK--GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVML-NDDNKRDKSCARYWSDK--G
  ..... | || .   ...||| |  .|.   ... | .|    |  ||| || |. .| |||| | .. .  .| || |  .|  | |. |.. |   
fkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

VKTFGP----VSVTT-----LSISE-RRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDSfsgvaEGfPVLVHCLNGVGR
| .|      .||       |.. .  .  ... . | .   .  . |..| ..||| .     | |  .|.|...   |      | |. |||  |.||
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla..ilellekarps.....kg.pivvhcsagigr

TGVFCtMLECI-AQINEEDAV-DVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSA
||    ||| |  |. . . . |  .... .|..|   .||...| ||...| .|.  
tgsvv.mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 116-294 2.4e-23 77.3 In-house 7-196 (198) alignment 
Range on Protein: 116-294
Range on HMM: 7-196/198.0
VSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWP--ESTSVNFGDIVVVLSSVASCCG----GLKRTLSLTKGAKTRVVNQFHFTEWPD
..  .|   .. |||.|||.     | ||   |   .     |||  ||.. ..| . |.  ....        |  | . |    || . .. || | .
iatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswke

KAVPNSTSTLQKYI--SEVKKDHGQN-SSPLLVHCSAGVGRTGVLLSIDSVVA--EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVY
|. || .  .   .   || | . |.  .|..|||| | | |||....|  |   |  .|  ||.|    ..|| |  .. . ..|.|.|
kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 115-305 2.5e-23 77.3 In-house 92-285 (301) alignment 
Range on Protein: 115-305
Range on HMM: 92-285/301.0
SVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTS--VNFGDIVVVLSSVASCCG--GLKRTLSL---TKGAKTRVVNQFHFTEW
 ..   | .....||| |. | .|..|.|...  | .. ||..| | ..|  .. |   . . .  .       |||| .   |.  .|| |  . ..||
fiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysew

PDKAVPNSTSTLQKYISEVKKdhgqNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSED
.|. ||.|   | . .  |||       |..||||||.||.  ... . .  | .  .....   . ..|..|   |||..|  .. .  .  |  | 
tdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikey
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 71-298 2.8e-23 76.8 In-house 49-282 (302) alignment 
Range on Protein: 71-298
Range on HMM: 49-282/302.0
KVNFEKNRYKNILPYDSSRVRLAITNDdpnsDYFNASYIPVN---KESVSKTRPNNASM---DDFWRMVWQENVNTIAMVTKLQEGTKiKCRQYWP--ES
| | .||. ...  .|| .|.|. ..|    .| ||| . |    .. .    |.  |    ..|||||.||.. .. .. . .| .|    ...|    
kknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

TSVNFGDIVVVLSSVASCCGGL-KRTLS-LTKG-AKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEV-KKDHgQNSSPLLVHCSAGVGRTGVLLSIDSVV
. ...|.. |    | .  .   . ..  | .| . . ..|  ..| |..| || . ..| | . .| .|.  . ......    |.|| |..|.   .|
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakki.kadentvivSknGaGRagafltlavav

AEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVL
 . .. ||. |   |..||..|| .|.. .|| ..|.|.|
eklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 336-435 4.7e-23 76.2 In-house 37-148 (392) alignment 
Range on Protein: 336-435
Range on HMM: 37-148/392.0
TQTATKTENRSKSRYANSLPMERNRVIL-QSRGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLND-----DNKRDKSCAR
...| |  |  | || | ||....||.|     ..|||..|||....      .|..|.| . .. ||| || . ...||.|...       . ....|.
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaq

Y----WSDKGVK
.    | ||.| 
fhftewPdkdvp
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 343-573 6.5e-23 76.3 In-house 18-255 (290) alignment 
Range on Protein: 343-573
Range on HMM: 18-255/290.0
ENRSKSRYANSLpMERNRVILQSRGSS-DSDFVNASFVKG-NRYRFITTQMPMPN-------TVADFWAMVIDYQPSTIVMLNDDNKRDKS-----CARY
..  . |....| .| .||.|.  |.   .|.. |..|.  |  |.| || |  .       |. .|| |. . .   .||| . .....      ||.|
khemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WSDKG--VKTFGPVSVTTLSISERRGFIEREIEVTQNKPKaRHVVKQYQFVDWPTKaEERKDHaPYLLNLMTEVEDSfsgvaeGFPVLVHCLNGVGRTGV
  ..     .|. ..|   |  .  ....||..|. .. .  . |. .....| .  . ..|.   ||.|.  |. |      . ||.||| .|. |  .
vpesvgeelkfkgltvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnkl.nvqedt.ktllsliqkvkas......ktpvivHcvdGiSrsAa

FCTMLECIAQIN-EEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELI
. ..      |   ...| . ...|.||..| . .......|||   |
laaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
0048076 (Phosphotyrosine protein) phosphatases II 184-298 1.3e-22 75.5 In-house 30-140 (145) alignment 
Range on Protein: 184-298
Range on HMM: 30-140/145.0
LKRT--LSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNsSPLLVHCSAGVGRTGVLLSIDSVVAeakrtKEVDIFGYVTKIRQNRP
...   |. ..   .| . |.... |||  ||.....|.. .  ... . ..  | ||||||||||||.|  .. .       . |...  . ..|. ||
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrp

YMVQTKEQYQFVYVAVL
..|.. .|..|.| ..|
gavpnpgqlrflyefel
0044763 (Phosphotyrosine protein) phosphatases II 365-580 4.2e-22 74.1 In-house 12-174 (178) alignment 
Range on Protein: 365-580
Range on HMM: 12-174/178.0
SRGSSDSDFVNASFVKGNryRFITTQMPmpntvADFWAMVIDYQPSTIVMLNDDNKRD-KSCARYWSDKGVktfgpvsvttlsiserrgfiereievtqn
 .|   ||. |||.. ..   ..... |     ||..... ..  ..||.|...  .   .| .|| ..                               
leglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

kpkarhvvKQYQFVDWPTKAEER-KDHAPYLLNLMTEVEDsfsgvAEGFPVLVHCLNGVGRTGVFCTMLECIAQineedAVDVFQMVKMLRNERMhFVQT
         ||... .|   .    .| . ..... |. |      .| ||||||  ||||.|... .  .. .      ..... ....|. |. .|..
........iqylhipipDhgvpdllehflefvefieeald.....ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpn

EEDYAFVYELINEYLSAN
.... ..||.  ..|. .
pgqlrqLyefelrllkes
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 344-578 4.6e-22 73.0 In-house 55-290 (305) alignment 
Range on Protein: 344-578
Range on HMM: 55-290/305.0
NRSKSRYANSLPMERNRVILqSRGSsDSDFVNASFVKGN---RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWSD-KGVKTFG
. .| ||..    ... | | .. |  ||.. | .|        ||| .| |. .|. .|| |||. .   ||||    .  |  ||.||   .| |   
aitknryqdvpcqdqsavkl.dkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

PVSVTTLSISERRGF-IEREIEVTQNK----PKARHVVKQYQFVDWPTKAEERKDHApyLLNLMTEVEDSfsgvaeGFPVLVHCLNGVGRTGVFCTMLEC
   .    .|  . .  . ||..|  .     . .  |.. |. .|| .       .   |.|.. .  |        |..|||  |.||||   ..   
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklt..slellsairgs......kvpivvhcsagigrtgtivaieyi

IAQINEEDAV-DVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
. .| |.  .  . ..|| ||..| . .|.. .| |.. .. .|. 
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 341-589 7.1e-22 72.4 In-house 44-291 (303) alignment 
Range on Protein: 341-589
Range on HMM: 44-291/303.0
KTENRSKSRYANSLPMERNRVILqsrgsSDSDFVNASFVKGN-RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKSCARY--WSDKGVKTF
  .|  | |... . ..  .| |     ||| .. ||... . . . | ||.|.. | |||| |.|. .   ...|  |.. ||    .    ..    |
fvknmdknrfvdvicldhskvkl.....sdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GPVSVT--TLS-ISERRGFIEREIEVTQNKPKARHVVKQYQfvDWPTKAeERKDHAPYLLNLMTEVEDSFSGVAEGFPVLVHCLNGVGRTGVFCTMLEC-
   |.    .  .    |.  . . |.. . |.   |..|.  .|| ..    | .| ... . ...  .   ... | .   | |.||.| |. .  . 
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphns.ipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

IAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSANEYEQLPVPV
..  .|. ..|. . ....|| |.| ||   ....|| |. |..  | . .| .| 
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 332-578 1.3e-21 71.8 In-house 24-271 (285) alignment 
Range on Protein: 332-578
Range on HMM: 24-271/285.0
TPLSTQTATKTeNRSKSRYANSLPMERNRVILQSRgssDSDFVNASFVKG---NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNK-RDKSCAR
 |  | || .. |    |||.   .|  ||.|. .   | |.. ||...    ..  .|||| |.|.|..||| |. . . . ..||    .   . || 
ppnctytayea.npdlnryadvrcieetrvvlknh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcal

YWSDK--GVKTFGPVSVTTLSISER--RGFIEREIEVTQNKPKARH--VVKQYQFVDWPTKAeERKDHAPyLLNLMTEVEDSFsgvAEGFPVLVHCLNGV
|. .|   |  ||   .|     |    | |   . |.. .  .     ... |   || .    .|  | ...|   |.       .  |. |||  ||
yypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdql.apedarp.mielykwvkkvn...pkekpicvhcsagv

GRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
|||  |  .  .  .| |.  ......|. .|  |.. ||.  .. |.| .. ||. 
grtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
0048179 (Phosphotyrosine protein) phosphatases II 194-295 3.8e-21 70.7 In-house 44-139 (144) alignment 
Range on Protein: 194-295
Range on HMM: 44-139/144.0
AKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQNsSPLLVHCSAGVGRTGVLLSIDSVVaeakrTKEVDIFGYVTKIRQNRPYMVQTKEQYQFV
  .| . |.... |||  ||.... |.. .  ... . ..  | ||||||||||||.|  .. ..     .. ....  .  .|. ||..|.. .|..|.
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

YV
. 
le
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 118-313 1.9e-20 68.0 In-house 39-232 (255) alignment 
Range on Protein: 118-313
Range on HMM: 39-232/255.0
KtrpnnaSMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST--SVNFGDIVVVLSSvaSCCGGLKRTLSLT----KGAKTRVVNQFHFTEWPDKA
       ..| |.... | . ....|.. ..| .. || .|.|        . |. |. .   |    . ||| .|    .  ||. |. .... |..| 
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekn

VPNSTSTLQkYISEVKkdhgQNSSPLLVHCSAGVGRTGVLLSIDSVVA------EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEd
 |. .  .. .|  |     ..| ...||||.|.||.  .  ...|        .   | |.|    ....|..|.  ..|  |  |  . ||. .  . 
aPelareil.nilkvv....rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk.

TRIQASYF
. ..| | 
geleakyq
subfamily_CG42327_pd Subfamily CG42327 48-227 8.2e-20 65.7 In-house 6-191 (319) alignment 
Range on Protein: 48-227
Range on HMM: 6-191/319.0
DVFyEEFLCLPkaNIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIPVNKES----VSKTRPNNASMDDFWRMVWQENVNTIAM
||. |||  ||  ..  .. .      .|.|. |..|   .|| |    ||... |..|||.   ...    .. . . . |  ||||.||. .  .|  
dva.eefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

VTKLQEGTKIKCRQYWPESTSV----NFGDIVVVLSSVASCCGGLKRTLSLTK--GAKTRVVNQFHFtEWPDKAVPNSTSTLQKYISEVK
.|.|.|    .| .|.| . .      .||| | |   ..    .  || | .  . ..| .  . . .|..  || . ..|   . ||.
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 342-571 8.2e-20 65.6 In-house 50-284 (310) alignment 
Range on Protein: 342-571
Range on HMM: 50-284/310.0
TENRSKSRYANSLPMERNRVILQSRGSSDSDFVNASFVKGNRY--RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK-SCARYWSDKGV-KTF
...  | ||.. . ..  || |.   |   |.. | .|| |     || .| |.  |. ||| |... .  .|..|    .  .  |  ||   || .|.
kkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GPVSVTTLSISERR--------GFIEREIEVTQNKPKARhvVKQYQFVDWPTKAEERKDHapylLNLMTEVEDSFSGVAEGfPVLVHCLNGVGRTGVFCT
| . || || |            |.  .. | ..  . .    . ... ||   .          .  |  .  .. |  | |..|||  |..|..| ..
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlk..elrvslikwpnwpdrgvpd....ekchtvpqrllaqvrhg.pcvvhcsagkdrlyvvva

MLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYE
.   | .... . ||. ...  |...|.  .||| .| ..  
lklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_egg_pd Subfamily egg 334-577 1.1e-19 65.2 In-house 30-270 (307) alignment 
Range on Protein: 334-577
Range on HMM: 30-270/307.0
LSTQTATKTENRSKSRYANSLPMERNRVILQ-SRGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRdKSCARYWS
 | .|| . .|. |.|       .  || |.  ||    ||. |  |||.     || .| |. ||| ||| ||   .   ||||.   .  . |  || 
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywp

----DKGVKTFGPVSVTTLSISERRGFIER--EIEVTQNKPKARHVvKQYQfVDWPTKAEerkDHAPylLNLMTEVEDSFSgvaegfPVLVHCLNGVGRT
    |  |   | . ...| . ..   . |  .. .   . . |.. . .|  |.   ..    . |  |...  . .         ||.|.. .|| ..
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerfl.ehwq.gdvnnssd...vysp..lrvlrklrnlsk......pvvvqdilGvska

GVFCTMLECIAQINEE--DAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
... ..   . ..         | . |..|| .|   |..   | ||| |.  ..
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 77-322 7.2e-19 63.0 In-house 23-280 (290) alignment 
Range on Protein: 77-322
Range on HMM: 23-280/290.0
NRYKNILpYDSSRVRLAITNDDPNSDYFNASYIPV--NKESVSKTRP-------NNASMDDFWRMVWQENVNTIAMVTKLQEGTKI----KCRQYWPEST
.|... |    .|| |       |.||. |... .  . . .    |        |. . .|| |. ||.|. . |. . .| ..      | .| ||| 
qRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv

S--VNFGDIVVVLSSVASCCGGLKRTLSLTKG-AKTRVVNQFHFTEWPDKAVPNSTSTLQKYISEVKkdhgQNSSPLLVHCSAGVGRTGVLLSIDSVVAE
   ..|... |   |     .  .|.| .. .  .   |.   . .| .  |...| || . |. ||    .. .| .|||  |. |  .| .|.     
geelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQk

AK-RTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQASYFESTLMHLQE
    ...| .   . ..|..|  ........ ||  ...  .  .  ..  ...|   .  ..
iaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeek
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 73-183 1.1e-18 62.1 In-house 47-171 (350) alignment 
Range on Protein: 73-183
Range on HMM: 47-171/350.0
NFEKNRYKNILPYDSSRVRLA--------ITNDDPNSDYFNASYIPVNKESVS---------KTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKC
 | ||||||||||. |||.|         .      .|| ||.|. ... ||.            |    .|||.... . .|. | ..|...|    ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

RQYWPEStsvNFGDIVVVLSSVASCCGG
 .||.|    .. || | |.|     .|
yrYWqeg...sydditvklaskwenimg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 343-436 2.5e-18 60.9 In-house 46-157 (350) alignment 
Range on Protein: 343-436
Range on HMM: 46-157/350.0
ENRSKSRYANSLPMERNRVILQ---------SRGSSDSDFVNASFVKGN--------RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKS
|  .| || | || |..||.|.             | .|..||...| .         ...| || |.|.|| ||. ...  .   |..|..|     . 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CARYWSDKGVKT
| ||| . ... 
cyrYWqegsydd
subfamily_hpo-7_pd Subfamily hpo-7 124-314 4.4e-18 60.1 In-house 45-242 (263) alignment 
Range on Protein: 124-314
Range on HMM: 45-242/263.0
ASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPES--TSVNFGDIVVVLSSVASccGGLKRTLSLTK--G--AKTRVVNQFHFTEWPDKAVPNSTS
  .| |.... | . ....|..  .|  . || .|.|        . .. |. . | |    |..|| |..  |   ||. |... .. |..|  |. . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

TLQkYISEVKKdhgqNSSPLLVHCSAGVGRTGVLLSIDSVVA------EAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTR--IQ
    .| .| .    || .| ||||.|.||.     ...|        .   | |.|    ....|..|.  ..|  |  |  . ||. .| . ..  ..
eil.nilkvar....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgele

ASYFE
| | |
akyqe
0048076 (Phosphotyrosine protein) phosphatases II 458-576 6e-17 57.1 In-house 34-142 (145) alignment 
Range on Protein: 458-576
Range on HMM: 34-142/145.0
IEVTQNKPKARHVVKQYQFVDWPTKAEERK-DHAPYLLNLMTEVEDSfsgvaeGFPVLVHCLNGVGRTGVFCTMLECIAqineEDaVDVFQMVKMLRNER
. .| ...   . . ||....||   .    .. . .|... |. ..      | ||||||  ||||||... .  ..     .. |.... ....|. |
lnltselellerlgiqylylpwpDhgvpdllellleflefieealke......ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqr

MHFVQTEEDYAFVYELINEY
...|.... . |.||.. |.
pgavpnpgqlrflyefelel
subfamily_CG42327_pd Subfamily CG42327 344-481 7e-17 56.1 In-house 28-173 (319) alignment 
Range on Protein: 344-481
Range on HMM: 28-173/319.0
NRSKSRYANSLPMERNRVILQSRGSSDSD-FVNASFVKGNR---YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD-KSCARYWSDK----GV
 . |||..|..|.   ||.||. |. |.| ...||.|.| .     .|..|... .. .||| .| . |  .|| | |  .   | ||.|.  |    . 
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

KTFGPVSVTTLS-ISERRGFIEREIEVTQNKPKARHVvKQYQFvDWPT
...| . ||     .. | .|   .    .| ..|..   | . .|. 
slyGdilvtlkgrevkdryaistlllkrvdkeesrel.thywy.kwle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 338-481 9.4e-17 55.8 In-house 27-176 (297) alignment 
Range on Protein: 338-481
Range on HMM: 27-176/297.0
TATKTENRSKSRYANSLPMERNRVILQsRGSSDSDFVNASFVK----GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLND--DNKRDKsCARYW--
.| .     | || . | .. .|| |. |. ...|..|| .|      . ...| .| |. .|| ||| .| . .  .|||.    .. ||| || ||  
sakrnsslrknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk.capywps

SDKGVKTFGPVSVTTLSISERRgFIERE-IEVTQNKPKARHVVKQYQFVDWPT
.... .. | | |  ||      |      |..    . . ||.  ||. || 
vvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 234-301 1.4e-16 55.3 In-house 228-295 (297) alignment 
Range on Protein: 234-301
Range on HMM: 228-295/297.0
SSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
. .|||||||||||.||..  | ..|  .. .  |.   ....|..|. .||| ||....| |||. |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 390-573 2e-16 54.3 In-house 97-284 (302) alignment 
Range on Protein: 390-573
Range on HMM: 97-284/302.0
QMPMPNTVADFWAMVIDYQPSTIVMLND-DNKRDKSCARYWSDK--GVKTFGPVSVTTLSISE-------RRGFIEREIEVTQNKP--KARHVVKQYQFV
 .|  .|.  .||.. .|. . .| | .  .. .| || |.|||  |. .||  .|.|.|. .       ...|    .|.. .|   | .. |.  .| 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DWPTKAEERKDHapYLLNLMTEVEdSFSGvaegfPVLVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELI
 || .   .. .  . |...   | |.        ||||| .|||||| . ..   |    ...  |. ..|. .|. |   ||.|.   ..  ..
awpdhGapkeay..taldilkfce.sykk.....nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_CG42327_pd Subfamily CG42327 227-296 6.5e-16 52.9 In-house 240-310 (319) alignment 
Range on Protein: 227-296
Range on HMM: 240-310/319.0
KKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRT-KEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVA
.  . ..  || |||| ||||||.... |  . . . . . |||   |  .|..|   |.|||||.|.|  
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
0048179 (Phosphotyrosine protein) phosphatases II 466-571 1e-15 53.2 In-house 42-139 (144) alignment 
Range on Protein: 466-571
Range on HMM: 42-139/144.0
KAR--HVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVEDSFSgvaEGFPVLVHCLNGVGRTGVFCTMLECIaqinEEDaVDVFQMVKMLRNERMHFVQTE
..   . . ||....||       |.. .||...  .|.  .   || ||||||  ||||||.....  ..    ... ..... ....|. |.. |...
pefleregiqylhlpwpDhgvp..dllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

EDYAFVYE
. . |..|
gqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 347-580 1.3e-15 51.9 In-house 46-279 (312) alignment 
Range on Protein: 347-580
Range on HMM: 46-279/312.0
KSRYANSLPMERNRVILQsrGsSDSDFVNASFVKG--NRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDD-NKRDKSCARYWSDK-GVKTFGPVSV
  || |    .| |  |   |  .  .. | |||   .  ||..|| |. ||.. || ...    ..|..|    .   . ||.| ||  |   .    |
lnrypniqcwdrgrftla..g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

TTLSISE-------RRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAeeRKDHAPYLLNLMTEVEDsfsgvaEGFPVLVHCLNGVGRTGVFCTMLECIA
 | . .|       .     | . |  .       ...||.  || .     |     | |.. |        .  ||. ||  |||||| .. .   ||
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhg..mpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmia

QINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSAN
 .      .| ..  .||..|   |..  .| ..   . |.| ..
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 391-583 1.7e-15 51.8 In-house 39-228 (255) alignment 
Range on Protein: 391-583
Range on HMM: 39-228/255.0
MpmpnTVADFWAMVIDYQPSTIVMLNDDNK-RDKSCARYWS--DKGVKTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEErk
.    ||. |. ...  .....||| | .    . | .|.     . . .  |.|||   |    .  .||  |  . |  | || |..  |. |     
l....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaP..

DHAPYLLNLMTEVEDSfSgvaegfPVLVHCLNGVGRTGVFCtMLECIAQ-----INEEDAV--DVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL-SA
. |  .||..  | ||        .|.||| .|.||.  |  . | . |     ... ..|  |  .... ||..|   ..|    ||   .. ...  .
elareilnilkvvrds.k......svvvhCstGiGrsaafv.laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk

NEYE
.|.|
gele
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 70-304 2e-15 51.2 In-house 42-282 (303) alignment 
Range on Protein: 70-304
Range on HMM: 42-282/303.0
KK--VNFEKNRYKNILPYDSSRVRLAitnddpNSDYFNASYIPVN--KESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST-S
..   |..|||. ...  | |.|.|.      .| |  |||. ..  | ..    | . .  |||.|. ...|. . ..    |  |.     .|.    
nqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

VNFGDIVVVL---SSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNS-TSTLQKYISEVKKD--HGQNSSPLLVHCSAGVGRTGVLLSIDSV-
..| . .. .     |    |   . ||...|     .   |. .|| ...|.  .. . | | ...    .  .|.| .    .|.||.| .  ...  
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

VAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSE
..  .    .|.   . ..|. | . ||   |. .||  . | .| .
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 198-298 5.1e-15 50.1 In-house 216-341 (350) alignment 
Range on Protein: 198-298
Range on HMM: 216-341/350.0
VVNQFHFTEWPDK-AVPNSTSTLQKY------I-SEVKKDHG--QNSSPLLVHCSAGVGRTGVLLSIDSVVAE-------AKRTKEV-------D-IFGY
|| |...  |.|   . |  | ||        | . . . |   ..|||.||||||||||||.|...||.. .        |. ...       | |.  
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VTKIRQNRPYMVQTKEQYQFVYVAVL
| ..|. |  |||...|. |.| |.|
vnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 29-110 9.1e-15 48.9 In-house 3-84 (440) alignment 
Range on Protein: 29-110
Range on HMM: 3-84/440.0
RRPIPLSQFATLVQKNRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDPNSDYFNASYIP
.||| ...||  ||.|| .  | .|.  || .   |  .|    |  ||||.||| || ||| |   .  |.||| ||||| 
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 71-163 1.1e-14 48.8 In-house 50-144 (310) alignment 
Range on Protein: 71-163
Range on HMM: 50-144/310.0
KVNFEKNRYKNILPYDSSRVRLAITNDdPNSDYFNASYIPVNK---ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST
| .. |||| ...  |.|||.| | .     ||  | |.  |      .    | . .. |||||..||  ..| .. |  |  . ||  |||   
kkymhknrysdvvcldtsrvklkidks.ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 343-577 1.2e-14 48.5 In-house 50-285 (302) alignment 
Range on Protein: 343-577
Range on HMM: 50-285/302.0
ENRSKSRYANSLPMERNRVILQSrgsSDSDFVNASFVKGN--RYRFITTQMPMPNTV---ADFWAMVIDYQPSTIVMLNDDNKRDKSCARYWS--DKGVK
.| .|..  .   .. |.|.|.    .  ..|||| |.    ..  | .|.|  ...   ..|| || . .  ..|.|  ... .|.   ..       |
knlkknqsedvpildsnlvklea...epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdyk

TFGPVSVTTLSISERRGFI-EREIEVTQNKPKARHVVKQYQFVDWPTKAEErkDHAPYLLNLMTEVedsFSGV-AEGFPVLVHCLNGVGRTGVFCTMLEC
..| . | .  ...  .   .  |||  .      ... | .  |. |     ..   | . ...|   |        ....   ||.|| |.| |.   
eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp..vkyaeliktaakv...fakkikadentvivSknGaGRagafltlava

IAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
. ........ . ..|| .|..| . |.. . |...|  .. |.
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 238-301 1.3e-14 48.3 In-house 2-65 (69) alignment 
Range on Protein: 238-301
Range on HMM: 2-65/69.0
LVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
.||||.| |||| ...|   .|  |  | ||||  |  .|. || ||  . .| |.. |. |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 239-301 2.6e-14 47.3 In-house 2-64 (69) alignment 
Range on Protein: 239-301
Range on HMM: 2-64/69.0
VHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEAL
||||.| |||| ...|   .|  |  | ||||  |  .|. || ||  ...| |.. |. |||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 195-304 5.9e-14 46.2 In-house 186-291 (302) alignment 
Range on Protein: 195-304
Range on HMM: 186-291/302.0
KTRVVNQFHFTEWPDKAVPNSTSTLQKYIsevkKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVY
. . |. ..|. |||.  |. . |  . .    |        .|||||||||||| |..|   .   .. |  |.   |. .|| |   ||...|  .. 
vkktvdilafsawpdhGapkeaytaldil....kfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

VAVLEALLSE
. |  .|.  
lcvtkglmek
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 341-577 1.5e-13 45.0 In-house 34-269 (281) alignment 
Range on Protein: 341-577
Range on HMM: 34-269/281.0
KTENRSKSRYANSLPMERNRVILQS--RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWSDK--G
.  |  | ||.|   ..  || |.        .|.. | ...    .  .| || |  .| |||| |. . . ..|||| .  .   . || |.  .   
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

VKTFGPVSVTTLSISERRGFIEREIEVTQNKpKARhVVKQYQFVDWPTKAEerKDHAPYLLNLMTEVEdsfsgvAEGFPVLVHCLNGVGRTGVFCTMLEC
.  |  .||.    .  . ..   .... .  ..| .. .. . .||       . .  .|... ..       |   | ..||  ||||.| . ..  .
clqfdklsvsyedstvnkslvttrlnlsyeg.etr.lithwlwkewpdwqv..pessevmlkilrkir......arstppvihcsagvgrsgtlmaveia

IAQINEEDA-VDVFQMVKMLRN-ERMHFVQTEEDYAFVYELINEYL
.  |    .  |. |.|  ||   |   ||| ..| ...... .. 
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 326-489 1.6e-13 44.8 In-house 78-240 (244) alignment 
Range on Protein: 326-489
Range on HMM: 78-240/244.0
NNKRRCTPLSTQTATKTENRSKSRYANSLPMERNRVILqSRGSSDSDFVNASFVK--GNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDK
.|  |  |   . | . .|  |.| . .||.. ||| | |.||    ..|||||   |    .| || |. .|  ||| |...     .|.|   .. |.
qniirpdpsvmkdafnpnnswknregaglpfdfnrvpl.skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede

scarYWSDKGVKTFGP--VSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWPTKAEERKDH
    || |     .    ..||     | .     ..|.  .  ..   .  .|  .||.     .||
....ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndh
subfamily_hpo-7_pd Subfamily hpo-7 395-576 6.6e-13 43.2 In-house 45-226 (263) alignment 
Range on Protein: 395-576
Range on HMM: 45-226/263.0
NTVADFWAMVIDYQPSTIVMLNDDNKR-DKSCARYWS--DKGVKTFGPVSVTTLSISErrGFIEREIEVTQ--NKPKARHVVKQYQFVDWPTKAEERKdh
.|.. |. ..   .....||| | |    . | .|.     . . .  |.|.|  . .    . . .|...  .. |  | ||.|... |. | . ..  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel..

APYLLNLMTEVEDSfSgvaegfPVLVHCLNGVGRTGVFCtMLECIAQ-----INEEDAV--DVFQMVKMLRNERMHFVQTEEDYAFVYELINEY
|   ||..  . .|        .. ||| .|.||.  |  . | . |     ... ..|  |  .... ||..|   ..|    ||   .. ..
areilnilkvarns.k......slvvhcstGiGrsaafs.vaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_CG42327_pd Subfamily CG42327 511-576 7.1e-13 42.9 In-house 248-314 (319) alignment 
Range on Protein: 511-576
Range on HMM: 248-314/319.0
FPVLVHCLNGVGRTGVFCTMLECIAQINEE-DAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEY
 |. ||| .||||||.  .    | ...|   .||. |.|  .|..| . |.| | |.|.|  . ||
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_eak_pd Subfamily eak 334-484 1.8e-12 41.3 In-house 42-194 (332) alignment 
Range on Protein: 334-484
Range on HMM: 42-194/332.0
LSTQTATKTENRSKSrYANSLPMERNRVILQSRGSSDSDFVNASFVKGNR--YRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD-KSCARYWS
|| . ....|.  .    . .| .|. | | |       ..||| .. .    ..| | ..  . |  || ||.. .  .||.| .| . . .   .|. 
lsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

DKG--VKTFGPVSVTTLSISERRGFIEREIEVTQNkpKARHVVKQYQFVDWPTKAE
||.  .  || . |.. .  .|  .  | .|...      | |. |..  |   . 
dktreelkfGildverkefvkrniletrllelskG..nethrvlhykvfGwtettl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 515-577 1.9e-11 38.1 In-house 2-64 (69) alignment 
Range on Protein: 515-577
Range on HMM: 2-64/69.0
VHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
|||  | |||| | ...  .|.|  |  ||.|  |. .|  |   |  |..| |... . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 514-577 2e-11 38.1 In-house 2-65 (69) alignment 
Range on Protein: 514-577
Range on HMM: 2-65/69.0
LVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYL
.|||  | |||| | ...  .|.|  |  ||.|  |. .|  |   |  | .| |... . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 510-573 5.6e-11 36.8 In-house 228-291 (297) alignment 
Range on Protein: 510-573
Range on HMM: 228-291/297.0
GFPVLVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELI
  ..||||  ||||.||       .|..  .   ||  ....||..|   ||| | . ..|...
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 344-433 6.3e-11 36.2 In-house 48-157 (349) alignment 
Range on Protein: 344-433
Range on HMM: 48-157/349.0
NRSKSRYANSLPMERNRVILQ---------------SRGSSDSDFVNASFVKGNRY----RFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRD-K
  .| || . || |  ||.|.               | ..   |..|| ..|  |.    ..|.||.|.| || ||. ...  .   .. ||||.. . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

SCARYWSDKG
 | .|| .  
kcdiywqels
subfamily_eak_pd Subfamily eak 67-220 1.1e-10 35.4 In-house 46-202 (332) alignment 
Range on Protein: 67-220
Range on HMM: 46-202/332.0
VAEKKVNFEKNrYKNILPYDSSRVRLAITNDDPNsDYFNASYI---PVNKESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPEST
....  . ..|   .|.|||   |||. .  ...  | ||| .    | .. .    ...  .  ||.|| ...  .| .. .  |    |  .|.|. |
etarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

--SVNFGDIVVVLSSVASCCGGLKRTLSLTKGAKTRVVNQFHFTEWPDKAVPNSTSTLQ
   ..|| . |   .         | | |.|| .|  |  ...  | . ..|     | 
reelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedfla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 198-297 1.8e-10 34.9 In-house 191-286 (310) alignment 
Range on Protein: 198-297
Range on HMM: 191-286/310.0
VVNQFHFTEWPDKAVPNSTS--TLQKYISEVKkdHGqnssPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYV
 |.  .. .|||. ||.       |. ...|.  ||    | .||||||..|..|.....  .  ..| ..||.   .|.....|   .||. || ..  
rvslikwpnwpdrgvpdekchtvpqrllaqvr..hg....pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr

AV
  
vr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 231-298 2.3e-10 34.3 In-house 262-341 (349) alignment 
Range on Protein: 231-298
Range on HMM: 262-341/349.0
GQNSSPLLVHCSAGVGRTGVLLSIDSVVA--EA----------KRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVL
 ...|.|||||||| ||||||  .|....  |           .  ..  |.  | ..|. |  |||   |. ..| |.|
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 501-578 3.7e-10 34.0 In-house 253-345 (350) alignment 
Range on Protein: 501-578
Range on HMM: 253-345/350.0
EDSFSGVAEGFPVLVHCLNGVGRTGVFCTMLECIA------QINEE-DAV--------DVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
  |..  |.. |.||||  ||||||...|.   .       ....|   .         ....|. ||. |.  ||. . . |.|| .  | .
aeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 30-109 1.1e-09 32.3 In-house 3-81 (95) alignment 
Range on Protein: 30-109
Range on HMM: 3-81/95.0
RPIPLSQFATLVQK--NRHTDVFYEEFLCLPKANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDdpnSDYFNASYI
.|| .| | . | .      . | .||  .. .   | ||   . |  |||. ||.|||..|| |.   |   ||| || ..
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 73-165 1.2e-09 32.0 In-house 48-159 (349) alignment 
Range on Protein: 73-165
Range on HMM: 48-159/349.0
NFEKNRYKNILPYDSSRVRLAITNDDP--------------NSDYFNASYIPVNK-----ESVSKTRPNNASMDDFWRMVWQENVNTIAMVTKLQEGTKI
 | |||||.||||. |||.|  .   .                || || |. . .       ...  |  ...|||....  ..|. .  ... .| .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCRQYWPESTSV
|| .|| | .  
kcdiywqelsys
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 43-127 6.6e-09 29.7 In-house 8-89 (244) alignment 
Range on Protein: 43-127
Range on HMM: 8-89/244.0
KNRHTDVFYEEFLCLPK-ANIFPQTVAEKKVNFEKNRYKNILPYDSSRVRLAITNDDpNSDYFNASYIPVNKEsvsKTRPNNASMD
. .  .|  |||. |   .  | || |   .|  |||| ||||.| .|| |. .. .  ||| ||.||  ...     ||. . | 
rlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgsqn...iirpdpsvmk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 122-299 7.6e-09 28.6 In-house 127-307 (346) alignment 
Range on Protein: 122-299
Range on HMM: 127-307/346.0
NNASMDDFWRMVWQENVNTIAMVTKLQEGTKIKCRQYWPESTSVNFGDIVVVLSSVASCCGGLKR-TL-SLTKGAKTRVVNQFH-FTEWPDKAVPNSTST
|.. ..||| |..||... . ..   .   .     .  |    ..   ...    |   |  |  |.  | .|    |. | |  . |     |  |  
nesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlp

LQKYISEVKKDHGQNSSPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLE
. | | . . ..  ..  . |    | ||.  ..     . .     | .|.  . .|.|.||  |..  ||  .|  |..
iikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
PTPc_motif_SM00404 458-573 4.2e-08 28.2 In-house 32-135 (140) alignment 
Range on Protein: 458-573
Range on HMM: 32-135/140.0
IEVTQNKPKArHVVKQYQFVDWPTKAEERKDHAPYLLNLMTEVEDSfsgVAEGFPVLVHCLNGVGRTGVFCTmLECIAQiNEEDAVDVFQMVkmlRNERm
|.||.....     ...|..  | . .| .. ..|| .... .|..    ..|  |||||  || |.. ...  ... . .. .. .....|   ...| 
invteevslt.kensgfqilqiplddnekdklskyldkvldfiena...ekkggkvlVHCqaGvSRSatlii.aYlmry.rqlslaeayefv...kerR.

hfVQTEEDYAFVYELI
  .. ..   ||..||
..piispnlnfvrqLi
subfamily_PTPDC1_pd Subfamily PTPDC1 202-293 5.3e-08 27.5 In-house 85-168 (182) alignment 
Range on Protein: 202-293
Range on HMM: 85-168/182.0
FHFTEWPDKAVPNSTSTLQkyISEVKKDHGQNSsPLLVHCSAGVGRTGVLLSIDSVVAEAKRTKEVdifgyVTKIRQNRPYMVQTKEQYQFV
..   |.|  |.  .. |.  |  | .   |.   . ||| || ||||||..   | |.   ...      ....|..||  .||.|| ..|
vynfgwkDygvasleriLd..ivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaeka.....iklvrskrpksiqtreqvelv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 354-483 1.7e-07 25.6 In-house 3-125 (130) alignment 
Range on Protein: 354-483
Range on HMM: 3-125/130.0
LPMERNRVIlqsrgssDSDFVNASFV--KGNRYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLNDDNKRDKscarYWSDKGVKTFGPVSVtTLSISERR
|..| .|.        . ...|||||   |.   .. || |. .|  ||| |...     .|.|   .. |.    || |     .    . ......| 
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede....ywpdsePlewyeedi.ivtltdrd

GF--IE-REIEVTQNKPKARHVVKQYQFVDWPTKA
.|  |.  ..|. ..  .. . .  .|  .||.  
efknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_eak_pd Subfamily eak 230-310 1.9e-07 24.8 In-house 232-314 (332) alignment 
Range on Protein: 230-310
Range on HMM: 232-314/332.0
HGQNSSPLLVHCSAGVGRTGVLLSIDSVV--AEAKRTKEVDIFGYVTKIRQNRPYMVQTKEQYQFVYVAVLEALLSEDTRIQA
|   |   .. .. |  |.||.. || ..   ..|..    .  .. |... | . | .. |. |.| .||. ||  . |.. 
htppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrd
DSPc Dual specificity phosphatase, catalytic domain 455-561 2.3e-07 25.7 Pfam-A 20-125 (133) alignment 
Range on Protein: 455-561
Range on HMM: 20-125/133.0
EREIEVTQNKPK-ARHVVKQYQFVDWPTKAEERKDHAPYLLNLMTEVEDSfsgVAEGFPVLVHCLNGVGRTGVFCTM-LECIAQINEEDAVDVFQMVKML
.  |.||...|.      ....... | . |. .. ...| .... .|.     ..|  |||||  |. |.. .... | .  ... ..|.....  .  
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrsk

RNERMHFVQ
 .....|..
ispnagflr
DSPc Dual specificity phosphatase, catalytic domain 455-561 2.3e-07 25.7 In-house 20-125 (133) alignment 
Range on Protein: 455-561
Range on HMM: 20-125/133.0
EREIEVTQNKPK-ARHVVKQYQFVDWPTKAEERKDHAPYLLNLMTEVEDSfsgVAEGFPVLVHCLNGVGRTGVFCTM-LECIAQINEEDAVDVFQMVKML
.  |.||...|.      ....... | . |. .. ...| .... .|.     ..|  |||||  |. |.. .... | .  ... ..|.....  .  
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrsk

RNERMHFVQ
 .....|..
ispnagflr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 343-417 3.1e-07 24.3 In-house 36-118 (347) alignment 
Range on Protein: 343-417
Range on HMM: 36-118/347.0
ENRSKSRYANSLPMERNRVILQS------RGSSDSDFVNASFVKGN--RYRFITTQMPMPNTVADFWAMVIDYQPSTIVMLND
 . || |  .   ..  ||.|        |      ..||| .| .  .  .| || |.|.|| ||| ||   . . .| . .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
0038934 (Phosphotyrosine protein) phosphatases II 201-294 3.8e-07 25.5 In-house 81-170 (194) alignment 
Range on Protein: 201-294
Range on HMM: 81-170/194.0
QFHFTEWPDKAVPNSTSTLQKYISEVKKDHGQN-SSPLLVHCSAGVGRTGVLLSIDSVVAeaKRTKEVDIFGYvtkIRQNRPYMVQTKEQYQFVY
...   .||. .. |...|..... |.. . .. .   .||| ||.||||.|.    .     . .  .  ..   .|. || .... .... ..
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAial...frekRpgaipnqdyleall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 508-578 2.1e-06 21.3 In-house 263-345 (349) alignment 
Range on Protein: 508-578
Range on HMM: 263-345/349.0
AEGFPVLVHCLNGVGRTGVFCTMLECIA--Q--INEEDAVDV--------FQMVKMLRNERMHFVQTEEDYAFVYELINEYLS
..  ..||||  | |||||..|.   ..  .   ||   ...        . .|  ||  |.  ||   .. ..|| . .|..
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 390-579 2.3e-06 20.5 In-house 124-311 (346) alignment 
Range on Protein: 390-579
Range on HMM: 124-311/346.0
QMPMPNTVADFWAMVIDYQPSTIVMLNDDNK-RDKSCARYWSDKGV-KTFGPVSVTTLSISERRGFIEREIEVTQNKPKARHVVKQYQFVDWptKAEerk
||     | ||| |. . |   . ..  |.| .. . . .  ..|  .  | . .            |  |||  .      ... ..   |  |     
qmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapw..khl...

DHAPYLLNLMTEVEDSFSG-VAEGFPVLVHCLNGVGRTGVFCTMLECIAQINEEDAVDVFQMVKMLRNERMHFVQTEEDYAFVYELINEYLSA
.. |  | ..  . . .|    .   | |  | | ||.  |   |  | |.|.    ......| ....|   |..  .|| .| .. .|.. 
qqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiar
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 354-434 2.7e-06 21.1 In-house 44-127 (332) alignment 
Range on Protein: 354-434
Range on HMM: 44-127/332.0
LPMERNRVILQSRGSSDsDFVNASFVKGN--RYRFITTQMPMPN-TVADFWAMVIDYQPSTIVMLNDDNKRDKSCARY-WSDKGV
  ....|| |  .   | || |||.| |   .  .| .| |. . |   || || . .|| |... | ....|  | |  ||.|.
ycfdhsrvelapqdgkd.dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgf
0038934 (Phosphotyrosine protein) phosphatases II 506-560 3.2e-06 22.4 In-house 111-166 (194) alignment 
Range on Protein: 506-560
Range on HMM: 111-166/194.0
GVAEGFPVLVHCLNGVGRTGVFC-TMLECIAQINEEDAVDVFQMVKMLRNERMHFV
   .|  |.|||  |.||||...   | .  ... |.|.. |....    .. ...
nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 120-172 5.5e-06 20.0 In-house 243-293 (440) alignment 
Range on Protein: 120-172
Range on HMM: 243-293/440.0
RPNNASMDDFWRMVWQENVNTIAMVTKLQEGTkikCRQYWPEST-SVNFGDIVV
 | .... ||||.| . .. || |. .|.. |   |  |||  | || || . |
mpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftv