Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 737-824 | 8e-48 | 158.1 | In-house | 1-88 (297) | alignment | ||
Range on Protein: 737-824
Range on HMM: 1-88/297.0
EEWPKERRPIPLSQFATLVQKNRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
||.||||||||||.||||||||||||||.||||||| |||.|||||.|.|||||.|||||||||.|||||||.|.||||||.|||...
eespkerrpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 745-824 | 1.3e-35 | 117.4 | In-house | 1-80 (515) | alignment | ||
Range on Protein: 745-824
Range on HMM: 1-80/515.0
PIPLSQFATLVQKNRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
|.||.|| . |.||||| .| ||| ||| ||.|||||....||.||||||||||| .|||| .||..|.|||.||||||
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 745-824 | 3.9e-31 | 103.1 | In-house | 2-81 (315) | alignment | ||
Range on Protein: 745-824
Range on HMM: 2-81/315.0
PIPLSQFATLVQKNRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
|||..|| ..|.||||| .| ||| ||. .|..|.||....||.|||||||||.| .|||| .|...|||||||||||.
pipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 743-824 | 2.8e-30 | 100.0 | In-house | 1-82 (392) | alignment | ||
Range on Protein: 743-824
Range on HMM: 1-82/392.0
RRPIPLSQFATLVQKNRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
|.||| .|| ..|.||||. .|.||| ||| .|.|||||.|..| .||||||||||| .|||| .|.. |||||.||||||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 743-823 | 5.6e-21 | 69.8 | In-house | 2-84 (564) | alignment | ||
Range on Protein: 743-823
Range on HMM: 2-84/564.0
RRPIPLSQFATLVQKNRHT--DVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
..||| ..... |.| . . | ||. .. . |. ..|.|..| .||||.||..|| |||.| ...|..|||||||.|
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfi
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 743-824 | 2.5e-20 | 67.7 | In-house | 3-86 (315) | alignment | ||
Range on Protein: 743-824
Range on HMM: 3-86/315.0
RRPIPLSQFATLVQKN-R-HTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
..|||| |. | | .. . | ... .|| ...| |||| | .|||| ||..|| |||.| ...|||.|||.||..|.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfid
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 752-824 | 6.8e-19 | 63.7 | In-house | 9-80 (317) | alignment | ||
Range on Protein: 752-824
Range on HMM: 9-80/317.0
ATLVQKNRHtDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
.. |. . ...||| |. .. . .||....| .||||..|||||.||||| ...|.|||||||||..
lldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvd
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 735-823 | 1.3e-17 | 59.5 | In-house | 15-99 (308) | alignment | ||
Range on Protein: 735-823
Range on HMM: 15-99/308.0
RSEEWPKERRPIPLSQFATLVQKNRHTDVFYEEFLCLPGANIFPQ-TVAKKQVNFEKNRYKNILPYDFSRVKLaiinnDPDSDYINASYI
|....... .... ... |..| . ..||| |. . .. .||... |..|||||.||||| ||||| |..||||||||.
rdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyv
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 735-823 | 1.6e-17 | 58.4 | In-house | 3-94 (330) | alignment | ||
Range on Protein: 735-823
Range on HMM: 3-94/330.0
RSEEWPKERRPIPLSQFATLVQKNRH--TDVFYEEFLCLPGANIFPQ-TVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
|| .|. |.|. .. ... . | ||| .|| ..| .|.|. | ||||. |||||||||| |. .. ..|||||||.|
rsrsgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfi
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 760-824 | 1.8e-17 | 59.2 | In-house | 18-82 (278) | alignment | ||
Range on Protein: 760-824
Range on HMM: 18-82/278.0
HTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
....|| |. .......|... |..|||||.|||||.||||| ...|.|||||||||..
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvd
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 745-824 | 2.5e-17 | 58.7 | In-house | 4-86 (288) | alignment | ||
Range on Protein: 745-824
Range on HMM: 4-86/288.0
PIPLSQFATLVQK--NRHTDVFYEEFLCLPGANI-FPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
.|...... ||.| ... ..||| |. .. .....|... |.|||||..||||| ||||| ......|||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyid
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 742-824 | 7.3e-17 | 56.3 | In-house | 3-88 (293) | alignment | ||
Range on Protein: 742-824
Range on HMM: 3-88/293.0
ERRPIPLSQFATLVQKNRH--TDVFYEEFLCLPGA-NIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
. .|| |..|.. |.|... | ||. | . ...|...|| .||||.|||||| |||||| ......||||||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyip
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 747-823 | 1.1e-16 | 56.9 | In-house | 12-92 (307) | alignment | ||
Range on Protein: 747-823
Range on HMM: 12-92/307.0
PLSQFATLVQKNRHTDVFYEEFLCLPGANIF---PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINND-PDSDYINASYI
. .. |... . ...|| |. ..| . ..|....| .|||||.||||| .|||| .... .|||||||||.
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyv
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 745-824 | 1.8e-16 | 55.9 | In-house | 15-94 (297) | alignment | ||
Range on Protein: 745-824
Range on HMM: 15-94/297.0
PIPLSQFATLVQKNRHTDVFYEEFLCLPGANIfPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINN-DPDSDYINASYIP
|. .. |. | . ....|| |. .. ....|....| .|||||.|||||.||||| ... |.|||||||||..
plsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvd
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 764-824 | 6.5e-16 | 54.0 | In-house | 2-66 (284) | alignment | ||
Range on Protein: 764-824
Range on HMM: 2-66/284.0
FYEEFLCLPGANIF---PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINND-PDSDYINASYIP
..||| |. ... . .||... |..|||||.||||| ||||| ...| .|||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvd
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 743-823 | 7e-16 | 52.6 | In-house | 3-83 (440) | alignment | ||
Range on Protein: 743-823
Range on HMM: 3-83/440.0
RRPIPLSQFATLVQKNRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.||| ...|| ||.|| . | .|. || . | .| | ||||.||| ||.||| | .. |||||||||||
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyi
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 761-824 | 2.4e-15 | 51.4 | In-house | 19-83 (318) | alignment | ||
Range on Protein: 761-824
Range on HMM: 19-83/318.0
TDVFYEEFLCL-PGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
. .. ||. | . . . .. . ..|| |||| |||.|| .|||| ......||||||.||.
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 756-823 | 3.2e-15 | 51.2 | In-house | 21-92 (298) | alignment | ||
Range on Protein: 756-823
Range on HMM: 21-92/298.0
QKNRHTDVFYEEFLCLPGANI----FPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.|. . .. .|| | . . ..||.|. | .|||| .|...|.||| | ...| .|||||||..
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsfl
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 775-823 | 3.5e-15 | 50.6 | In-house | 28-76 (290) | alignment | ||
Range on Protein: 775-823
Range on HMM: 28-76/290.0
NIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.........|..| .|||||.|||||.|||.| |.....||||||..|
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfi
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 753-824 | 6.9e-15 | 50.7 | In-house | 3-71 (273) | alignment | ||
Range on Protein: 753-824
Range on HMM: 3-71/273.0
TLVQKNRHTDVFYEEFLCLPGANI-FPQTVAKKQVNFEKNRYKNILPYDFSRVKLaiinNDPDSDYINASYIP
|..| ......||| |. . .. .||... |..|||||.||||| ||||| .|..||||||||..
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvd
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 768-824 | 7.1e-15 | 50.5 | In-house | 20-72 (297) | alignment | ||
Range on Protein: 768-824
Range on HMM: 20-72/297.0
FLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLaiinNDPDSDYINASYIP
.|| .... .||... | ||||||.|||||..|||| .|..||||||||..
eellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvd
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 757-823 | 1e-14 | 49.3 | In-house | 16-83 (288) | alignment | ||
Range on Protein: 757-823
Range on HMM: 16-83/288.0
KNRHTDVFYEEFLCLPGAN-IFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
. | . | ||. |. . .|.... || .||||.||||||. |||| .. ...||||||||
sarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyi
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 759-823 | 1.4e-14 | 48.9 | In-house | 20-84 (319) | alignment | ||
Range on Protein: 759-823
Range on HMM: 20-84/319.0
RHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
. . .|| .| .|. . . |.|. | .||||.|||.|| .||.|. ... ..|||||||.|
tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfi
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 778-824 | 4.6e-14 | 48.1 | In-house | 2-48 (249) | alignment | ||
Range on Protein: 778-824
Range on HMM: 2-48/249.0
PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
. .||....| .||||..|||||.||||| |... ..|||||||||.
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyid
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 756-823 | 6.6e-14 | 46.8 | In-house | 17-84 (325) | alignment | ||
Range on Protein: 756-823
Range on HMM: 17-84/325.0
QKNRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.| . | | || || . ..|| | | .|||.||....| ||| | ..||.||||||||.
kkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasyl
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 780-823 | 7.8e-14 | 47.1 | In-house | 2-45 (245) | alignment | ||
Range on Protein: 780-823
Range on HMM: 2-45/245.0
TVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.||....| .||||..|||||..|||| ...|.|||||||||.
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 754-823 | 2.6e-13 | 44.8 | In-house | 13-84 (307) | alignment | ||
Range on Protein: 754-823
Range on HMM: 13-84/307.0
LVQKNRHTD-VFYEEFLCLPGANIFPQT-VAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
|....|.|| . .|. |. .| .| |..|. | ||||..| ..| ||||. || . ||||||||.|
lksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfi
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 764-823 | 2.9e-13 | 44.5 | In-house | 28-89 (306) | alignment | ||
Range on Protein: 764-823
Range on HMM: 28-89/306.0
FYEEFLCL---PGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAiINNDPDSDYINASYI
| ||| | . . .. ..|. | ||||||||||.| .||.|. .. |.||||||.||
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyi
|
|||||||||
DSPc_SM00195 | 778-823 | 3e-13 | 45.1 | In-house | 17-62 (263) | alignment | |||
Range on Protein: 778-823
Range on HMM: 17-62/263.0
PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
. | |.|. | .||||||||||| .|||| ......||||||.||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyi
|
|||||||||
PTPc_SM00194 | 778-823 | 3e-13 | 45.1 | In-house | 17-62 (263) | alignment | |||
Range on Protein: 778-823
Range on HMM: 17-62/263.0
PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
. | |.|. | .||||||||||| .|||| ......||||||.||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyi
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 781-823 | 1.7e-12 | 42.0 | In-house | 2-44 (239) | alignment | ||
Range on Protein: 781-823
Range on HMM: 2-44/239.0
VAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
|||.|| |||| ||. ||.||| | ..||| ||||||||.
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasyl
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 782-823 | 2.3e-12 | 41.6 | In-house | 2-43 (239) | alignment | ||
Range on Protein: 782-823
Range on HMM: 2-43/239.0
AKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
|||.|| |||| ||. ||.||| | ..||| ||||||||.
akkrvnkaknryanivtydhsrvvleklsndphsdyinasyl
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 762-824 | 3.5e-12 | 41.0 | In-house | 15-78 (281) | alignment | ||
Range on Protein: 762-824
Range on HMM: 15-78/281.0
DVFYEEFLCLPGANIF-PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYIP
| ||. | ... . | .|.. | .||||.|| || .|||.. ... ..|||||...|
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 764-823 | 7.2e-12 | 39.7 | In-house | 24-79 (314) | alignment | ||
Range on Protein: 764-823
Range on HMM: 24-79/314.0
FYEEFLCLPGAnifpQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
| ||. .|. .|||. | ||||...||.|| |||.| |..||.||||||..|
fkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 760-823 | 7.7e-12 | 40.7 | In-house | 6-59 (278) | alignment | ||
Range on Protein: 760-823
Range on HMM: 6-59/278.0
HTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKlaiinndpdsDYINASYI
.|...| . |. .. |.| . |..|||||.|||||.|||| ||||||||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyi
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 780-823 | 1.1e-11 | 39.4 | In-house | 2-45 (250) | alignment | ||
Range on Protein: 780-823
Range on HMM: 2-45/250.0
TVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.|||| | ||||| .|...| ||| | . | .|||||||..
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasfl
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 780-823 | 4e-11 | 37.5 | In-house | 35-78 (297) | alignment | ||
Range on Protein: 780-823
Range on HMM: 35-78/297.0
TVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
...|...| |||||...| || .||.|| ...|. ||||||...
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfv
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 774-823 | 4.3e-11 | 36.7 | In-house | 34-84 (563) | alignment | ||
Range on Protein: 774-823
Range on HMM: 34-84/563.0
ANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDS-DYINASYI
.. .. . ..|. | .|||| ||..|| |||||. . . .. |||||.||
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyi
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 769-823 | 8.9e-11 | 36.6 | In-house | 43-97 (319) | alignment | ||
Range on Protein: 769-823
Range on HMM: 43-97/319.0
LCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.| |.| || | . | .|||. |||..| ..||| .. |||||||..
acklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfv
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 779-823 | 1.1e-10 | 37.0 | In-house | 2-40 (243) | alignment | ||
Range on Protein: 779-823
Range on HMM: 2-40/243.0
QTVAKKQVNFEKNRYKNILPYDFSRVKLaiinndPDSDYINASYI
...|....| .||||..|||||.||||| ..||||||..|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanli
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 770-823 | 2e-10 | 35.7 | In-house | 8-61 (284) | alignment | ||
Range on Protein: 770-823
Range on HMM: 8-61/284.0
CLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
| |.| || | . | .|||. .||..| ..||| . |||||||.|
cklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfi
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 787-823 | 2.6e-10 | 35.5 | Pfam-A | 1-35 (235) | alignment | ||
Range on Protein: 787-823
Range on HMM: 1-35/235.0
NFEKNRYKNILPYDFSRVKLaiiNNDPD-SDYINASYI
|..|||||.|||||..|||| ..... ||||||.|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 787-823 | 2.6e-10 | 35.5 | In-house | 1-35 (235) | alignment | ||
Range on Protein: 787-823
Range on HMM: 1-35/235.0
NFEKNRYKNILPYDFSRVKLaiiNNDPD-SDYINASYI
|..|||||.|||||..|||| ..... ||||||.|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 780-823 | 7.7e-10 | 33.1 | In-house | 34-73 (280) | alignment | ||
Range on Protein: 780-823
Range on HMM: 34-73/280.0
TVAKKQVNFEKNRYKNILPYDFSRVKLAiinnDPDSDYINASYI
..|.| | .||||..||||| |||| . ..|||||.|.
saarkpenlsknryrdilpydatrvklk....esetdyinanyv
|
|||||||||
subfamily_Sponge-PTP3_pd | Subfamily Sponge-PTP3 | 744-823 | 8.3e-10 | 32.7 | In-house | 3-81 (95) | alignment | ||
Range on Protein: 744-823
Range on HMM: 3-81/95.0
RPIPLSQFATLVQK--NRHTDVFYEEFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAiinNDPDSDYINASYI
.|| .| | . | . . | .|| .. . | || . | |||. ||.||| .|| |. ||||||| ..
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfv
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 750-823 | 1.1e-09 | 32.3 | In-house | 4-78 (296) | alignment | ||
Range on Protein: 750-823
Range on HMM: 4-78/296.0
QFATLVQKNRHTDVFYE-EFLCLPGANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.| ||.| |. | |. |. | .| . .. | ||||. ...|||. || | .. . .||||||.|.
kflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyv
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 745-823 | 1.5e-09 | 32.4 | In-house | 3-82 (305) | alignment | ||
Range on Protein: 745-823
Range on HMM: 3-82/305.0
PIPLSQFATLVQKNRHTDV--FYEEFLCLPGAnIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
.| |...|. ....| .. . ... |. . | ||..| .|||.|.| ..|..|..|. ....|||||||||.
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyv
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 774-823 | 5e-09 | 30.3 | In-house | 19-64 (290) | alignment | ||
Range on Protein: 774-823
Range on HMM: 19-64/290.0
ANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNdpdsDYINASYI
|. ||...||.. | ..|||... ||| ||.|| .| |||||| .
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslv
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 767-823 | 5.3e-09 | 30.5 | In-house | 28-84 (300) | alignment | ||
Range on Protein: 767-823
Range on HMM: 28-84/300.0
EFLCLPGANIF-PQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDpDSDYINASYI
|. .| . ..|| ..| ||||.|..|||. .||.|. ... ...||||| |
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassi
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 773-823 | 1.2e-08 | 29.1 | In-house | 42-92 (297) | alignment | ||
Range on Protein: 773-823
Range on HMM: 42-92/297.0
GANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
|. ..|||.. | .|||.|..|||| ||||| ... .||||||| |
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 780-823 | 1.5e-08 | 29.3 | In-house | 30-68 (273) | alignment | ||
Range on Protein: 780-823
Range on HMM: 30-68/273.0
TVAKKQVNFEKNRYKNILPYDFSRVKLAiiNNDPdsdYINASYI
.|.||. | .||||.|.|||| .|||| .. . |||||.|
evgkkkenkdknryrnvlPydetrvklg..degg...yinasli
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 781-823 | 1.8e-08 | 28.5 | In-house | 37-75 (288) | alignment | ||
Range on Protein: 781-823
Range on HMM: 37-75/288.0
VAKKQVNFEKNRYKNILPYDFSRVKLAiinnDPDSDYINASYI
.| ... ||||...||||| .|||| . ||||||..
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfv
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 759-823 | 2.1e-08 | 28.2 | In-house | 8-74 (281) | alignment | ||
Range on Protein: 759-823
Range on HMM: 8-74/281.0
RHTDVFYEEFLCLPGANIFP-QTVAKKQVNFEKNRYKNILPYDFSRVKLAI-INNDPDSDYINASYI
| | .|| ||| || .. || .|||| || | |||.| . . | .||| | ||
mtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyi
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 763-823 | 2.9e-08 | 28.1 | In-house | 6-65 (274) | alignment | ||
Range on Protein: 763-823
Range on HMM: 6-65/274.0
VFYEEFLCLPgANIfPQTVAKKQVNFEKNRYKNILPYDFSRVKLA-IINNDPDSDYINASYI
...||| || .| .| . . .|||||.||| . ||| | ..|.||.|||| ||
dlekeflelP.lnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyi
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 780-823 | 3.3e-08 | 29.1 | In-house | 39-80 (314) | alignment | ||
Range on Protein: 780-823
Range on HMM: 39-80/314.0
TVAKKQVNFEKNRYKNILPYDfSRVKLAIINNDpDSDYINASYI
.||.. .| .||||..|||.| .||.| ... .||||||||.
lvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyv
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 784-823 | 3.6e-08 | 27.7 | In-house | 17-56 (270) | alignment | ||
Range on Protein: 784-823
Range on HMM: 17-56/270.0
KQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
. . |||..||| .||.|. ...|. . |||| |.
aargkklnRyadiLPsPatRvrleeleedsataYinAnyv
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 746-823 | 3.8e-08 | 27.6 | In-house | 2-84 (290) | alignment | ||
Range on Protein: 746-823
Range on HMM: 2-84/290.0
IPLSQFATLVQKNR--HTDVFYEEFLCLP-GANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPD--SDYINASYI
||...|. |.... .. | ..| | |.. . ||. . | ..||..||..|| |. | |....| .||||.||
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyi
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 782-823 | 6.9e-08 | 26.6 | In-house | 42-83 (418) | alignment | ||
Range on Protein: 782-823
Range on HMM: 42-83/418.0
AKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
|. | |||| |||| ...||.| |.. |||||| ||
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 757-823 | 1.2e-07 | 25.6 | In-house | 8-74 (244) | alignment | ||
Range on Protein: 757-823
Range on HMM: 8-74/244.0
KNRHTDVFYEEFLCLPG-ANIFPQTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDpDSDYINASYI
. . .| |||. | . | || | .| |||| ||||.| .|| |. ... ||||||.||
rlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyi
|
|||||||||
hEGF | Human growth factor-like EGF | 210-222 | 1.7e-07 | 19.9 | Pfam-A | 1-13 (13) | alignment | ||
Range on Protein: 210-222
Range on HMM: 1-13/13.0
TCICPPGFMGKNC
||.||||. |.||
tCqCppGyTGpnC
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 787-823 | 1.7e-07 | 25.3 | In-house | 47-91 (350) | alignment | ||
Range on Protein: 787-823
Range on HMM: 47-91/350.0
NFEKNRYKNILPYDFSRVKLA--------IINNDPDSDYINASYI
| ||||||||||. ||||| . .|||||.|.
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYl
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 781-823 | 2.1e-07 | 25.1 | In-house | 27-67 (297) | alignment | ||
Range on Protein: 781-823
Range on HMM: 27-67/297.0
VAKKQVNFEKNRYKNILPYDFSRVKLAiiNNDPDSDYINASYI
.||.. . ||||..|| .| .|||| . ...||||| |.
sakrnsslrknryrdilatddtrvkll..rviterdyinadyv
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 782-824 | 3.2e-07 | 24.4 | In-house | 33-74 (287) | alignment | ||
Range on Protein: 782-824
Range on HMM: 33-74/287.0
AKKQVNFEKNRYKNILPYDFSRVKLAiINNDPDSDYINASYIP
|.. . .|||| ..||.| .|| |. . . |||||| |..
aeelaavkknryadvlPiddtrvlls.aegelGsdyinanyva
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 746-823 | 4.7e-07 | 24.1 | In-house | 2-79 (287) | alignment | ||
Range on Protein: 746-823
Range on HMM: 2-79/287.0
IPLSQFATLVQKNRHT--DVFYEEFLCLPGANIFPQ--TVAKKQVNFEKNRYKNILPYDFSRVKLAiinnDPDSDYINASYI
||...|. .|.|.... . | . | | . .. |.. . | .|||...||..| || | . . |||||..|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfi
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 779-823 | 4e-06 | 20.5 | In-house | 40-84 (439) | alignment | ||
Range on Protein: 779-823
Range on HMM: 40-84/439.0
QTVAKKQVNFEKNRYKNILPYDFSRVKLAIINNDPDSDYINASYI
..| .. . |||||.. ..|..|| | | | | |||| ||
aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyi
|