Gene SpurPTP-sf1-12 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP089_AA protein Get Run
SpurP089_AA_457-732 phosphatase_domain Get Run
SpurP089_AA_744-1018 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 456-908 0.0 1028.7 In-house 1-453 (515) alignment
Range on Protein: 456-908
Range on HMM: 1-453/515.0
PIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTD
|.|||||||||||||||.||||||||||||||||||||||||||.||||||||||||.|||||||..||||||||||||||||||||||||||||.||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKE
||||.|.||||||||||||||||||||||||||..||||||||.||||||||||||||||||.|..||||.|||||||||||||||||||||||||.|||
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGD
|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.||||||||||||||
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

GRGRSKMTKEFQTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||| ||||.|
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstiv

MLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT
|||||||||||||||||||||||||||||||||||||||||||||.|||||| 
mlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskr

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 455-769 2.4e-186 612.9 In-house 1-315 (315) alignment
Range on Protein: 455-769
Range on HMM: 1-315/315.0
KPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNAST
.|||.||||||||||||||||||||||||.|.||.|.||.|.|||.|||||||||.|||||||||||..|.|||.|||||.|.|.||||||||||..|| 
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
|||||||.||.||||.||||..||||||| .|||.  .|||.||.|||||.||||.|.|..||... |....||||||.|||||||||.|.||||||.||
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSG
|||||.|. ...|..||||||||||||||||.|||..| ||.|||||||.|.|.||||.|||.|.|||||.|||||||||||||.|.||||||||||.|.
evkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsv

DGRGRSKMTKEFQTL
||.|||||||||.||
dgsgrskmtkefetl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 455-771 1e-170 562.4 In-house 2-276 (392) alignment
Range on Protein: 455-771
Range on HMM: 2-276/392.0
KPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNAST
.||| |||||||.||||.|||.|||||||||.||||||||.|||  |||||||||||||||||||||. |.|||.||||||||||.|||||||||| || 
qpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

DDFWRMVWQENVTTIAMVTKLKEGDkikcgkywpkipgdsvkfgnikvelvsleactggikrkmtmiKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
|||||||.|||||||||||||||||                                          ||||.|||.||||||||||.|||||||||||||
ddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfik

EVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSG
|||||.||.|||||||||||||||||||||||||||||.||||||||||||||.||||||||.|||||||||||||||||||||||||||||||||..|.
evkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstss

DGRGRSKMTKEFQTLKS
||..|||..|||..||.
dGdvrskqlkefrslka

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 774-1022 1.2e-127 420.2 In-house 29-282 (315) alignment
Range on Protein: 774-1022
Range on HMM: 29-282/315.0
PDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-S
|||.....|..|...|..||||.|.|||...||.|    ||||.||||||..|....  .....|.||...|.|||..||..|..|.||...|...|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPD--ANSVQFGSYSVSTLSTSSDGDMTIRQLkVTRNSKTSHTVTQYQFHGWPKHGSDPQLGarSLMKLIRAVKSStNKMNEFSILVHCLSGAGRT
|.|||||  |.||.|||..|..||...|.|...|.| |||.|..|.||||.||..||..|.| |..  ||.|||..||.. |...|||.||||..|.|||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
||.....|..|||....|||.|..||.|||.|...|||||||||.||...|.|.  | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

subfamily_PTPRD_pd Subfamily PTPRD 454-809 4.3e-123 406.9 In-house 2-358 (564) alignment
Range on Protein: 454-809
Range on HMM: 2-358/564.0
NKPIPLAQFPAFVNKNR--HTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNN
.|||| |.....|.| .  . . |.||....  ..  . ..|....|  ||||.||..||. ||.|. ..... ||| |||.| .....|||||.||| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGdSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSL
 ...|||||||..|..|| |.|||.| .| || ||||.  | . ..|...|.|.. |  .  . |.... |   .. |.|.|||||.|||.|||... ||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQD
|..|..|.| . . ..|...||||||||||. | ||...  .|. ..||....|...|..|..||||.|||.||. |.|| |   || ... ....||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LHSSGDGRGRSKMTKEFQTLKSLCPDPpASHTRSGRTRDNHPKNRYGNNLPLQRNRVILD
|..  .. . ... .||| |..  ... ...  ..    |. |||. | |.|...||.|.
LaeveedtemtgleleFqrLatakeie.leefavatkpknkkknrfsnilalescrvvls

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 454-744 1.2e-119 393.9 In-house 7-297 (297) alignment
Range on Protein: 454-744
Range on HMM: 7-297/297.0
NKPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNdkAYIASQGPNNAS
 .||||..|...|.||||| .|||||..||  ||.|||||.. .|| |.|||||||||| ||||......| |||.|||..... .   .|..| |..|.
rrpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

TDDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPK--HTSSL
 .|||.||..|.|.||.|.....|.|| || .||..    ...||.. |.| |.. ..|.|||.... ||.    | | |..|.||||| |..  ..|||
vadfWamvldeqvstivmlnddnerdk.kcaryWsdk..gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl

LKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFT
||.|.||. |..| .. ||..||.||||||||...||||||.|| .  ||.|..|. .||.|||.|||.|||.|.| |||| ||  .| |.. .|.
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 883-1024 1.5e-92 305.1 In-house 251-392 (392) alignment
Range on Protein: 883-1024
Range on HMM: 251-392/392.0
SVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS
 ...||||||||.. .|||..|..|.|||||||||||||||||| |.|||||.|||||||.|||.  |||||||||||||||||||||||||||||||||
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegds

VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
||||||||||||||||||||||||||||||||||||||.|||
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq

subfamily_PTPRB_pd Subfamily PTPRB 453-729 1.1e-90 298.7 In-house 3-283 (293) alignment
Range on Protein: 453-729
Range on HMM: 3-283/293.0
SNKPIPLAQFPAFVNKNR--HTALFSEEFHDLPGP-NIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGP
..||| | .| ..|.|..    . ||||...|    .   ...|....| .||||.|||||| .||||. ......||| ||.||| .   . .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

NNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSL
   ..||||||||......| |.|.| |. |.|| .|||.   ..| .|.|||.||. |  .  . |.... |... |.|.|.||| ||| |||..|..|
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

LKFIKEVKADH--GQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|.|...|.  .   . ..|...||||||||||. |..| .. . ... .||.| .|...|..| ..|||..|| ||. .||.
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 472-769 1.3e-90 298.7 In-house 19-318 (318) alignment
Range on Protein: 472-769
Range on HMM: 19-318/318.0
TALFSEEFHDL-PGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIA
. |.|||.. | . ..   .. . |..| .|||| |||.||..||||. ..... ||| ||.||. . ..|||||.|.|     .|||||||. | ..| 
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTM--IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH-GQFTHPL
|.|...|  |.|. .|||.   .| ..|...||| .   ..  . |....   . .. |.| |.|.|.|||.|||....|||.....|.. .  . ..|.
mltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
..||||||||||| | .|... ..|   .||||..|...|..|. ||||..|| ||| ..|| |   .| .   ........|. .    |...|  |||
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq

TL
 |
rl

0051299 (Phosphotyrosine protein) phosphatases II 456-729 2.4e-90 298.2 In-house 4-284 (288) alignment
Range on Protein: 456-729
Range on HMM: 4-284/288.0
PIPLAQFPAFVNK--NRHTALFSEEFHDLPGPNI-YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNA
.|.. ..  .|.|   ...... |||..|.  .. .....|. . |..||||..|||||. |||| |.|....||| |||||. .......|| ||| . 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI------KGDDYRTVTQFHFTEWPDKGVPKHT
...|||||||..||..| |.||| | ...|| .|||   |.|...|.|.|.|.| | . . ..|....       ... .||||.||.| ||| ||| ..
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

SSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..||.|...|.  . .  .| ..||||||||||..| .| .. . .....|||...|  .|..||.|||| ||| |.| |.||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0050432 (Phosphotyrosine protein) phosphatases II 452-735 4.9e-90 297.3 In-house 21-303 (308) alignment
Range on Protein: 452-735
Range on HMM: 21-303/308.0
SSNKPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQ-TVAQEEINFTKNRYKNILPYDSARVKLevidnNPHSDYFNASYIPSF--DNDKAYIASQG
 |...... ..  ...|   . |..|||..|.   .... .||. . |..|||||.|||||. ||||     ...||| ||||.. .  ......|| ||
vsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPG-DSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKH
| . ...|||||||..||..| |.||| | ...|| .|||  .| .|...|...|.|.| | . . ..|.... .  ....||||.||.| ||| ||| .
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

TSSLLKFIKEVKADHGQftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
...||.|...|.  ...  .| ..||||||||||..| .| .. . .....||||. |  .|..||.|||| ||| |.| |.|| |... 
peilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_PTPRA_pd Subfamily PTPRA 455-765 2.9e-89 294.2 In-house 12-329 (330) alignment
Range on Protein: 455-765
Range on HMM: 12-329/330.0
KPIPLAQFPAFVNKN--RHTALFSEEFHDLPGPNIYP-QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNN
 |.|. ..   ...     . || |||  ||  .|     .|..| |  |||. |||||| .|| | |.. ...||| |||.|  . . . .||.||| .
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI------KGDDYRTVTQFHFTEWPDKGVPKH
 . .|||||.|. . .|| |.|.||| .. || .|||.    .| .|||.||.   . .     ||. .       . .. | |.||||| ||| ||| .
etvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

TSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTD
.  .||..|.||. . | . |...||||||||||  | .|.|..  |. |.||||.|| ..|..|| ||||.||| ||| ..||  |. .| . |. .  
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

HLQDLHSSGDGRGRSKMTKE
||| |...  |  .  . .|
hlqklynkitgtdkigleee

0040438 (Phosphotyrosine protein) phosphatases II 459-768 7.6e-89 293.4 In-house 5-313 (317) alignment
Range on Protein: 459-768
Range on HMM: 5-313/317.0
LAQFPAFVNKNRHtALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFW
| ..  ...|. .  ...|||.||.  .... .||. . |  ||||..|||||. |||| .... ..||| ||||.. ..  ...|| ||| . ...|||
lllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV
||||...||.| |.|.|.| ...|| .|||   |.....|...|.|.| | . | . |....   .... ||||.||.| ||| |||.....||.|...|
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDG
..   .  .|...||||||||||..| .. .. . .... |||.. |  .|..||..||| ||| |.| |.|| |....||.|. ..  .|. |.    .
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

RGRSKMTKEFQT
 . . ..||...
ddvklkekelkl

0046845 (Phosphotyrosine protein) phosphatases II 476-737 1e-87 289.4 In-house 3-280 (284) alignment
Range on Protein: 476-737
Range on HMM: 3-280/284.0
SEEFHDLPGPNIY---PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNN-PHSDYFNASYIPSF-----DNDKAYIASQGPNNASTDDFWRMVWQENV
 |||. |.  ...   . .||. . |..|||||.|||||. |||| ..|.. ..|||.||||.. .     .. |..|| ||| . ...|||||||..||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TTIAMVTKLKEGDKIKCGKYWPKIpGDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG--
..| |.|.| | ...|| .||| . |.....|...|.|.| | . . ..|.... .   .. .||||.||.|.||| ||| ....||.|...|.  .   
rvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

QFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTR---MVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
   .| ..||||||||||..| .| .  . ....   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 762-1023 1.3e-87 288.7 In-house 23-290 (297) alignment
Range on Protein: 762-1023
Range on HMM: 23-290/297.0
MTKEFQTLKSLCPdpPASHTRSGRTRDNH---PKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTV
.  .. . . ||.  |.. .... . ...   .|.|| | || ...||.|    |.|| ||.||| .||..  ..||||| ..|| ||| .||....||.
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTNKMNEFSI
|||||....||.||.||.|  ...||. || .||.|.   .  |.|.||... |. . | ||||  ||..  . .  |.||.|||  |. . .. .|  .
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
|||||.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.||| .. |.| .|...
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 454-750 6.6e-87 286.4 In-house 3-298 (315) alignment
Range on Protein: 454-750
Range on HMM: 3-298/315.0
NKPIPLAQFPAFVNKNRHT--ALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNN
 .|||| |. ..| ... .    | ...  .|| ...|  ||..  |  |||| ||..|| .||.| ...|.||||| ||..|. ..  . |||.|||| 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpgdSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLK
|| .||||.|..|....| |.|.| ||.| |. ||||      | .|.| | ..| |  |    | .... ||. |.| |.|.| ||| ||||.| .|..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmn

FIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDL
.|. ||  | .   ....||||||||||  |..|.|. .|.. ...||.||.|..||.|  |||. ||| ||| |.|| ..  .| |    . .. . |
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 471-767 7e-86 283.2 In-house 21-319 (319) alignment
Range on Protein: 471-767
Range on HMM: 21-319/319.0
HTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIA
 . |. .||..| ...    . |..|.| .||||.|||.|| .||.|  .|. . ||| |||.| .... ...|| |.| .  ..|||||||.|.. .. 
getllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTM-IKGDDY--RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD-HGQFTHP
|.|||.|  |.|. ||||.   . ...|.. |.| . |   . |.||... .| ..   |.|..|..|||||..||... |||...|...   ...   |
mltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEF
...||||||||||  | .| .. . |   ..|||..| ..| .|. |||..||| ||| |.|| .   .| | | .. | |..| .   . | ... .||
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref

Q
|
q

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 469-728 1.9e-85 281.4 In-house 17-276 (288) alignment
Range on Protein: 469-728
Range on HMM: 17-276/288.0
NRHTALFSEEFHDLPG-PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVT
 |  . ||||.. |.   .   .|....  | .||||.||||||  ||||.  .... .|| ||||| . ...|.|||.|||. .. .|||..|......
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIAMVTKLKEGDKIKCGKYWPKiPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPL
||.|.|.| ||.| ||..|||.  .. ...|...|.||. .  .  ..||. . |  . ...||.... |||.|||. .  ||.... ||  . . | |.
tivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
|.||||||||||. |..| .. . ... ..||...|...|..|. .|||..|| ||| ..|
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 466-736 4.6e-85 280.5 In-house 20-295 (298) alignment
Range on Protein: 466-736
Range on HMM: 20-295/298.0
VNKNRHTALFSEEFHDLPGPNI----YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMV
|.|. . . ...||. |   .       ..||... |  |||| .|...||.|| || .|.. .||| |||.. .... .|.||.|.| .... ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVTTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD
..|...|| |.|.|.| ||.|. ||||.    . ..|.|.|.| | |  .  |.||... | .  . |.| |.|||.|||||||....|.|.....|.| 
teedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

HGQFT-HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
. |   .|.|..|||||||.|  | ||||. ..|. ..||||. |  .|.||| .|||.|||.||| |||| |   |.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

0036941 (Phosphotyrosine protein) phosphatases II 468-742 6.4e-85 280.3 In-house 9-288 (297) alignment
Range on Protein: 468-742
Range on HMM: 9-288/297.0
KNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLevidNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVT
..  . | .|  . ||  .... .||. . | .|||||.|||||. ||||    ....|||.||||.. .| ....|| ||| . ...|||||||..|||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEA--CTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-
.| |.|.| | ...|| .|||   |.|...|...|.|.| |   ... . |.... .  ... ||||.||.| ||| ||| ...|||.||..|.  . . 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-FTHPLIIHCSAGVGRTGVVISIDSVVAHAK---TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVH
   .| ..||||||||.|..| .| ..   .   ... ||....|  .|..|| .||| ||| |.| |.|| |....| .|.. 
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

0047943 (Phosphotyrosine protein) phosphatases II 465-729 2.5e-84 278.3 In-house 4-270 (273) alignment
Range on Protein: 465-729
Range on HMM: 4-270/273.0
FVNKNRHTALFSEEFHDLPGPN-IYPQTVAQEEINFTKNRYKNILPYDSARVKLevidNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQ
...|  ...|. |||..|.    ... .||. . |..|||||.|||||. ||||    ....||| ||||.. ..  ...|| ||| . ...|||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

ENVTTIAMVTKLKEGDKIKCGKYWPKIPGD-SVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH
.||..| |.|.| | ...|| .|||   |. |...|...|.|.| | . . ..|.... .   ...||||.||.|.||| ||| ...|||.||..|.  .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GQ--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 .    .| ..||||||||||..| .| .. . .....|||.. |  .|..||.|||| ||| |.| |.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_Ptp69D_pd Subfamily Ptp69D 464-750 5.8e-84 276.8 In-house 12-305 (307) alignment
Range on Protein: 464-750
Range on HMM: 12-305/307.0
AFVNKNRHT-ALFSEEFHDLPGPNIYPQT-VAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMV
|.....|.|  .. .|.. |.  .|  .| |.... |  ||||..| ..|. ||||..|  . .||| |||.| .... | .||.|.| .|  .|||||.
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

WQENVTTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKG-------DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
.. .||.| |...|.| .. || ||||.   | |..|.| |.||| | ..  |.|.. . |        .| | |.|.|.|.|.|  ||... .|||.|.
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDL
.|.  . .   |...||||||||.|.....||.. . |.   ||.|..| ..|..|. .||  ||| |.| |.|.   . .| . | .. |... |
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

subfamily_PTPRK_pd Subfamily PTPRK 476-768 2.4e-83 274.6 In-house 25-314 (314) alignment
Range on Protein: 476-768
Range on HMM: 25-314/314.0
SEEFHDLPGPniypQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKL
 ||.  |.        .|... | .|||...||.|| .||.| .||..|.||| ||..| |. . .|.|. ||| .  . ||||.|..|| ..| |.|.|
keeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel

KEGDKIKCGKYWPKipgDSVKFGNIKVELVSLEACTGGIKRKMTMIK----GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHC
.|  ..|| ||||.   |. ..|.||||||. |. .  ..| ... |     ...|.| ||.|. ||| .||..  .|||....||. . .   ....||
vevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

SAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQT
||| ||||. | ||.|.  ... ..||||| | ..|.... ||.|.||| ||| ..||  |  .| ||| .|     .          |.. .||||
saGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 455-751 3.2e-83 274.4 In-house 2-303 (305) alignment
Range on Protein: 455-751
Range on HMM: 2-303/305.0
KPIPLAQFPAFVNKNRHTA--LFSEEFHDLPGPnIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNA
|.| |... |.....| .    . .... |.     .  | ..| | .|||.|.| ..|  |..|   .....||| ||||. .... |.||..||| . 
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSL
  .||||....| |.|| |.|||.||.| || .|||.  .....||...||| | .. .. |.||... .    .. |||.|...|.|||.|||. ..||
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

LKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQ
|..||.|. |. .    ||..||||||||||| |..|  . ..|.  .||||. . ..|.||..||||..|| |.. |. | .   .| | .  .. ...
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

DLH
 |.
klk

0043336 (Phosphotyrosine protein) phosphatases II 470-729 1.2e-82 272.8 In-house 17-275 (278) alignment
Range on Protein: 470-729
Range on HMM: 17-275/278.0
RHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTI
   .|...||..|.  .......|. . |..|||||.|||||. ||||..... ..||| ||||.. ..  ...||.|||.. ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLKEGDKIKCGKYWPkipGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPL
 |.|.|.| ...|| .|||   |.|...|...|.|.. | . . . |....   . . .||||..|.. ||| ||| ..|.||.|.|.|.       .|.
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..||||||||||..| .. .. ...... ||... |  .|..|| .|||..|| |.| |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

DSPc_SM00195 489-729 1.5e-82 272.2 In-house 17-260 (263) alignment
Range on Protein: 489-729
Range on HMM: 17-260/263.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. | |... | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .   .|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

KIPGDSVKFGNIKVELVSLEACT-GGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISID
.  |.. .||.|.|.||. | .    |.|.... | .  . |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 489-729 1.5e-82 272.2 In-house 17-260 (263) alignment
Range on Protein: 489-729
Range on HMM: 17-260/263.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. | |... | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .   .|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

KIPGDSVKFGNIKVELVSLEACT-GGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISID
.  |.. .||.|.|.||. | .    |.|.... | .  . |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

subfamily_PTPN12_pd Subfamily PTPN12 486-729 5.9e-82 269.8 In-house 28-275 (290) alignment
Range on Protein: 486-729
Range on HMM: 28-275/290.0
NIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGK
..|.......| | .|||||.||||| .||.|. |.....||| ||..|   .....|||.|||  .  ||||||.|. ||. . |. .. | .|.|| .
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPKIPGDSVKFGNIKVELVSLEACT-GGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISI
|||.  .....||...|.| . .|.. . . | ... . .. |.|.|||.|.|||.|||. ..|||..|..|.  . .  .||..||||||||||..|.|
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| |    |. ..   .|||. |...|..|. .|||.||| ..| ||.|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

0039614 (Phosphotyrosine protein) phosphatases II 457-736 3.3e-81 268.3 In-house 16-294 (297) alignment
Range on Protein: 457-736
Range on HMM: 16-294/297.0
IPLAQFPAFVNKNRHTALFSEEFHDLPGPNIyPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNN-PHSDYFNASYIPSFDN-DKAYIASQGPNNAST
.    .  ...|   . |. .|| .|.  .. ....|. . | .|||||.|||||. |||| ..|.  ..||| ||||.. .|  ....||.|||.. ..
lsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

DDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPKIPGdsvKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
.|||||||...||.| |.|||.| .. || .|||   |   ..|...|.|.. | . | . |.... ...  ||||.|..| ||| ||| ....||.|..
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefle

EVKADHGQ--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
.|.  . .    .| ..||||||||||..| .. .. . .... |||.. |  .|..||..||| .|| |.| |.|| |....|
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 473-731 5e-81 266.9 In-house 15-276 (281) alignment
Range on Protein: 473-731
Range on HMM: 15-276/281.0
ALFSEEFHDLPG-PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAM
| | ||...|    .  . | .... | .||||.||  || .|||..  ..| ..|| ||...|.....|.|||.|||  || ..||.|||...|..|.|
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

VTKLKEGDKIKCGKYWPkIPGDSVKFGNIKVELVSLEACTGGIKRKMTM-IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLII
||.  |..|.|| .|||  .  ..|.|...|. .. |. .  |.||...  .. . |.|.|...| |||.|||. |. ||.| |||.  .  .  .||.|
vtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||||||||. |..| .| .. ......|| . |...|..| .||||  ||.|.| |||. |
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0045450 (Phosphotyrosine protein) phosphatases II 467-729 6.3e-81 267.8 In-house 21-302 (307) alignment
Range on Protein: 467-729
Range on HMM: 21-302/307.0
NKNRHTALFSEEFHDLPGPN---IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNN-PHSDYFNASYI--------PSFDNDKAYIASQGPNNAST
..  . ... .||..|.  .   ... ..|. . | .|||||.|||||. |||| ..|.. ..|||.||||.        ...|.....|| ||| . . 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

DDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGDSVKFGNIKVELVSLEACTGGIKRKMTMI---KGDDYRTVTQFHFTEWPDKGVPKHTSSLLK
.|||||.|...||.| |.|.|.| ...|| .|||   |... .||..|.|.| | . | . |....    . .  ||||.||.|.||| |||.....||.
edFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

FIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
||.||.. ...    .| ..||||||||||..| .. .  . ... .   ||... |  .|..|| .||..||| |.| |.||
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

Y_phosphatase Protein-tyrosine phosphatase 498-729 8.6e-80 262.9 Pfam-A 1-235 (235) alignment
Range on Protein: 498-729
Range on HMM: 1-235/235.0
NFTKNRYKNILPYDSARVKLeviDNNP-HSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVK
|..|||||.|||||. ||||   .... .||| ||.|. .....|..||.||| . . .|||||||||.|..|.|.|.|.| .. || .|||.  ..|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGNIKVELV-SLE-ACTGGIKRKMTMIKGDDY---RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA
.|.|||||. . . .... . ||... | ..    |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 498-729 8.6e-80 262.9 In-house 1-235 (235) alignment
Range on Protein: 498-729
Range on HMM: 1-235/235.0
NFTKNRYKNILPYDSARVKLeviDNNP-HSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVK
|..|||||.|||||. ||||   .... .||| ||.|. .....|..||.||| . . .|||||||||.|..|.|.|.|.| .. || .|||.  ..|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGNIKVELV-SLE-ACTGGIKRKMTMIKGDDY---RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA
.|.|||||. . . .... . ||... | ..    |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 491-731 1.1e-79 262.2 In-house 2-242 (250) alignment
Range on Protein: 491-731
Range on HMM: 2-242/250.0
TVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIkCGKYWPKi
.||..  |  |||| .|...||.|| ||  . . .||| |||.. ..|. ||.||.||| .|.. ||||||..|...|| |.|.||| .|  . .|||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.

pGDSVKFGNIKVELVSLEACTGGIKRKMTMIKG--DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSV
   . |.|...|.| | |  .  .|||. . |    | |.| |.||. |||||||... . |...|.|.| . |  . |.|..|||||||.|  | ||.|
.ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
. ..|. ..||||...  .|..|| .|...||| |.| ..|. |
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 469-766 1.1e-76 253.0 In-house 19-323 (325) alignment
Range on Protein: 469-766
Range on HMM: 19-323/325.0
NRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMV--WQenv
 .    |. ||  ||  .   ..||    |  |||.||....| .|| ||  ...|.|||.||||. .. . . ..|.| |. |...|.||.|  |.   
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

TTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTM--IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT
... .|.   ...| .| .||||  |.|..|| ..|.|...|  .  ..|.. .  .|. . |.| ||..  |.| ||.|. ..|. ... ||| . . |
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

H------PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRG
       |...||||||||||| ||. |..|.  .   ||.|.|| ..|..|| ||.| .|| .|| |. | ..  || .||  |  .|  |.       
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltq

RSKMTKEF
. .. |||
klniekef

0050432 (Phosphotyrosine protein) phosphatases II 726-1019 5.7e-76 251.1 In-house 7-301 (308) alignment
Range on Protein: 726-1019
Range on HMM: 7-301/308.0
AVLEDLLWRNTLIPVVHFTDHLQDLHS-SGDGRGRSKMTKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILdSPDHDYINASQMKGI
|.|| ||.|.| |.|.... ...||.    .  ..... .||..| |..|      .....  .|..|||| . ||. ..||.| ....|||||| ..| 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgy

----HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDA---NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQY
     ..|  || |||.|| ||| .| ... ...|||..  .|. . ||||||.    .|...| ..| .||. ...|.|.|.|..|  ... |.|||..
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthf

QFHGWPKHGSDPQlgARSLMKLIRAVKSSTnkmNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
....|| ||  |.  ...|......|..|    ..  |.|||  | ||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | |.|... |
hytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

YLHT
||..
ylkl

0040439 (Phosphotyrosine protein) phosphatases II 489-729 9.7e-76 249.9 In-house 2-244 (249) alignment
Range on Protein: 489-729
Range on HMM: 2-244/249.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. .||. . |  ||||..|||||. ||||..... ..||| |||||. ..  ...|| ||| . ...|||||.|....|.| |.|.|.| ...|| .|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

KipGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVISI
   |.|...|...|.|.| | . . . |....   . .. |||.....| ||| |||.....||.||..|.  . .    .|...||||||||||..| .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. .. . .... ||... |  .|..||..||..||| |.| |.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 474-735 8.2e-75 247.1 In-house 20-291 (563) alignment
Range on Protein: 474-735
Range on HMM: 20-291/563.0
LFSEEFHDLPG---PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHS-DYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTI
 |||||..|     ..  . . .|.. |  |||| ||..||..||||. . .. .. || ||.||  .   ||.||.||| .  .||||||.|..||..|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMIK-----G---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG
 |.|.|.|  . ||  ||||   .|...|...| |.. |  .   .|.... .     .   |. ..|.|.|.|.|||.|||.|.   |.|.|  .| . 
vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

QFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
. . |...||||||||||. | .|...   ..  .|.||.|.  || .|...|||.||| |.. |.|| .. ..
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

subfamily_PTPN6_pd Subfamily PTPN6 472-728 1.4e-73 242.5 In-house 25-294 (306) alignment
Range on Protein: 472-728
Range on HMM: 25-294/306.0
TALFSEEFHDLP---GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEvIDNNPHSDYFNASYIP--SFDNDKAYIASQGPNNASTDDFWRMVWQENV
 | |.|||..|      . . .. ..   | .|||||||||.| .||.|.  .. | ||| ||.||   . ..||.|||.||  ..   |||||||||| 
kagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

TTIAMVTKLKEGDKIKCGKYWPKIPGDSVkFGNIKVELVSLEACTGGIKRKMTMI---KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF
. | |.||  |  | || .|||.   ..  .|.|.|. || .. .  | |....    |... |.| |.||..|||.||||... .|.|...|.. . ..
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

T----HPLIIHCSAGVGRTGVVISIDSVVAHAKT---TRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.     |...|||||.|||| .| || ..   ..      .|. ..|  .|. |  .|||..|| |.| |. 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

0051299 (Phosphotyrosine protein) phosphatases II 735-1017 3.5e-73 241.9 In-house 2-286 (288) alignment
Range on Protein: 735-1017
Range on HMM: 2-286/288.0
NTLIPVVHFTDHLQDLHssgdGRGRSKMTKEFQTLKSLCPDppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--IHCTF
.| |.| ....... |.     .| ... .||..| ||.||    ......   |..|||| . ||. ..||.| .    ...|||||| ..|  . ..|
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

MTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-----NSKTSHTVTQYQFHGWPK
. || |||.||.||| .| ... ...|||..   .. . ||||||. .|...| ..| .||. ...|.|.|.|.||.      ...|.|||......|| 
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

HGSDPqlGARSLMKLIRAVKSSTNkMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||  .   ...|....|.|... .  ..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.. |||.| | |||... |||
hgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0042113 (Phosphotyrosine protein) phosphatases II 492-729 1.1e-72 239.7 In-house 3-241 (245) alignment
Range on Protein: 492-729
Range on HMM: 3-241/245.0
VAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKip
||. . | .||||..|||||. |||| .......||| ||||.. ..  . .||.||| . ...|||||.|....||| |.|.. | ...|| .|||   
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLIIHCSAGVGRTGVVISIDSVV
|.|...|...|.|.| | . . . |....   . | .|.|...|.. ||| ||| ....||.|...|.        .|...||||||||||..| .. ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

AHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 ...... |.... |  .|..|| .|||..|| |.| |.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPN9_pd Subfamily PTPN9 461-729 3.7e-72 237.9 In-house 5-288 (297) alignment
Range on Protein: 461-729
Range on HMM: 5-288/297.0
QFPAFVNKNRHTALfSEEFHDLPGPNIYP-QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWR
.. |.|.....  | |.|. ..   ..    ....   | .||||...| ||..||.|. .|....||| ||...  . . ||.|| ||| .  ..||||
elvayvkekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK
|||...| .| |.|.. |  ..|||.|||.  ..| .||...|. |. |      .|....   | .. |.|| | |. ||| |||. ..|||.....|.
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

ADHGQFT-------------HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
   ....              |...|||||.||||  |..|  ... ... .|||.. |  .|..| ...||.|||.| | ||||
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 484-752 8.3e-72 237.2 In-house 47-312 (319) alignment
Range on Protein: 484-752
Range on HMM: 47-312/319.0
GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTklkegdKIKC
|.|   || |  . |  |||. |||..| ..|||| ..    ||| |||..  . . . |||.||| . . .|||||.|. |..|| ..|      | ||
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkc

GKYWPKIPGDSVKFGNIKVELVslEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRT
 .|||.      . ...||..|  | .   . |.. . .     | | .|||||  |||.|||...| |....| |.  . .    .....|||||||||
sqywplkivikeerfkvkvdsv..eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHS
|| | .| ..   |  ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| .
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn

0045098 (Phosphotyrosine protein) phosphatases II 475-733 1.8e-71 236.1 In-house 10-274 (278) alignment
Range on Protein: 475-733
Range on HMM: 10-274/278.0
FSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKlevidnnphsDYFNASYIPSFdnDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTK
..| .. |. ....  |.|. . |. |||||.|||||. |||          || |||||...  .|..|| ||| .  ..|||||.|....|.| |.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI------KGDDYRTVTQFHFTEWPDKGVPKHT--SSLLKFIKEVKADHGQ----
|.|....|| .|||   |.|. .|...|.|.| | .   ..|.....      ...  |.||..|.. ||| ||| ..  .|.|........ . .    
lvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------FTHPLIIHCSAGVGRTGVVISIDSVVAHAktTRMVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLEDLLW
           .| ..||||||||||... .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0046845 (Phosphotyrosine protein) phosphatases II 762-1019 2.4e-71 235.8 In-house 2-276 (284) alignment
Range on Protein: 762-1019
Range on HMM: 2-276/284.0
MTKEFQTLKSLCPDPPaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGI-------HCTFMTTQMPLPTTVSDFWSLVLNY
. .||..| || ...   ... ..   |. |||| . ||. ..||.|.|     .|.|||||| ..|        ...|. ||.|||.|| ||| .|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTVVMLNDKSQNDK-SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSST
. ...|||..  .|..  ||||||. . ....| ..| .||.  ..|.|.| |..|..  .. |.|||......|| ||  |.  ...|....|.|... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrell

NK-MNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
..  ..  |.|||  | ||||.|.... .. |. ...    ||....|| ||  |...|||.| | |||... ||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 493-729 5.7e-71 233.4 In-house 2-238 (239) alignment
Range on Protein: 493-729
Range on HMM: 2-238/239.0
AQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKip
|.. .| .|||| ||. || .|| || . |.||||| ||||.  .|   |||||.||  ..|. |||||.|||    | |.| | || | || .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..

gDSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVA
  . |. |..| |   |  .  | | . | .    . | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... 
.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||  . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 493-729 7.1e-71 233.1 In-house 3-239 (239) alignment
Range on Protein: 493-729
Range on HMM: 3-239/239.0
AQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKip
|.. .| .|||| ||. || .|| || . |.||||| ||||.  .|   |||||.||  ..|. |||||.|||    | |.| | || | || .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..

gDSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVA
  . |. |..| |   |  .  | | . | .    . | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... 
.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||  . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 484-751 7.7e-71 233.9 In-house 11-275 (284) alignment
Range on Protein: 484-751
Range on HMM: 11-275/284.0
GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTklkegdKIKC
|.|   || |  . |  |||. .||..| ..|||| .. .  ||| |||.|  . . . |||.||| . . .|||||.|. |..|| ..|      | ||
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

GKYWPKIPGDSVKFGNIKVELVslEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRT
 .|||.      . ...||..|  | .   . |.. . .     | |...||||  |||.|||...| |....| |.  . .    .....|||||||||
sqywplkivikeerfkvkvdsv..eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLH
|| | .| ..   |  ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| 
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 736-1021 1e-69 230.1 In-house 3-294 (298) alignment
Range on Protein: 736-1021
Range on HMM: 3-294/298.0
TLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIHC--TFM
| | . ... .|| | .     . .....|||.|.|   . .. ... .|...|. |||| . ..|.  ||.| .     . |||||| ... .   .|.
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafi

TTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDP
.|| ||..||.||| .| ... .|.|||..  . ||  . .|||| .. ..|. .|| ||. . .|...|.|||.... .....| | .|  || .|   
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe

QlgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.  |.|...|.| |. |...  . ...|.| .| ||.| |.     . .. .  .||.||.||.||..|.. |||||.|.|.|... |.|.. |
n..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

DSPc_SM00195 762-1017 1.3e-69 229.8 In-house 2-262 (263) alignment
Range on Protein: 762-1017
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
. .||..|..  ..    .|....   |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| .|.. | ...|
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMnE
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|.|..| .  .....|||||...||.|| .    ..|...|.||||.|...  .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.s

FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 762-1017 1.3e-69 229.8 In-house 2-262 (263) alignment
Range on Protein: 762-1017
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
. .||..|..  ..    .|....   |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| .|.. | ...|
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMnE
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|.|..| .  .....|||||...||.|| .    ..|...|.||||.|...  .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.s

FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 496-729 1.7e-69 228.8 In-house 18-262 (270) alignment
Range on Protein: 496-729
Range on HMM: 18-262/270.0
EINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFD-NDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGD-
  . . |||..|||   .||.|| ....... |.|| |.. || ..|.|||..|| .... .||||.|.|.||.|.|.|.|.|  . || .|||. |.. 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-SVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTS------SLLKFIKEVKADHGQFTH--PLIIHCSAGVGRTGVVISI
 ....|.|||  .| |  .| |...... .  . | .. |....|||.|||...       .||| ...|.. . .. .  ||..||||||||||..| .
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| .|   ..|. ||| . ....|..|. .||. |||.|.| ||.|
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

0047943 (Phosphotyrosine protein) phosphatases II 757-1017 2e-69 229.4 In-house 9-272 (273) alignment
Range on Protein: 757-1017
Range on HMM: 9-272/273.0
RGRSKMTKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTV
 |.... .||..|.||.|      .. ..  .|. |||| . ||. ..||.|.....|||||| ..|  .  .|. ||.||| || ||| .| ... ...
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLNDKSQNDK-SCAQYWPDAN---SVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM-
|||..  ....  ||||||. .   |...| ..| .||. ...|.|.|.|..|. ... |.|||.....||| ||  |     ||...|..|..  ..  
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkalealp

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.  |||.| | |.|... |||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 758-1021 3.8e-69 228.6 In-house 11-281 (297) alignment
Range on Protein: 758-1021
Range on HMM: 11-281/297.0
GRSKMTKEFQTLKSLCPDPPashTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
..... |||..| .| ....   .. ..  .| .|||| . ||. ..||.||....|||||| ..| .   .|. || |||.|| ||| .|.... ...|
flalllkefeellpllllgs...lsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSS--DGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM-
||..  ....  ||||||.   .|...| ..| .||...  ..|.|.|.|.||  ... |.|||.....||| ||  .   ..||...|..|..  ... 
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllp

NEFSILVHCLSGAGRTGVFCTAMECIAQIA---EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
..  .||||  | ||.|.|..|  .. |.    .   |||...|| ||  |.. |||.| | |.|... |.| . .
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

subfamily_PTPRD_pd Subfamily PTPRD 777-1023 9.8e-69 227.4 In-house 36-287 (564) alignment
Range on Protein: 777-1023
Range on HMM: 36-287/564.0
PASHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQ
. ..... .   | .|||| | ..  ..||.|      .. |||||| ..| .   ... || ||..|..||| .| ... ||.|||.  . ..|  |..
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKV-TRNSKTSHTVTQYQFHGWPKHGSdPQLGaRSLMKLIRAVKSSTnKMNEFSILVHCLSGAGRTGVFC
|||. .. ..|.. |.  ..    |..||..|. . .|. |..|.|..|  || ||  |. . .||..||| |.... . ..  |.||| .| ||||.|.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv.pesa.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
.   .. .| | . |||.|.|| ||..|   ||||| |.|....| |.|.  | |
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

0037934 (Phosphotyrosine protein) phosphatases II 491-729 8.3e-68 223.8 In-house 3-240 (243) alignment
Range on Protein: 491-729
Range on HMM: 3-240/243.0
TVAQEEINFTKNRYKNILPYDSARVKLevidnNPhSDYFNASYIPSFDNdkaYIASQGPNNASTDD----FWRMVWQENVTTIAMVTKLKEGDKIKCGKY
..|. . | .||||..|||||  ||||     .. |||.||..|. ...   .||.||| . ...|    ||||.|....|.| |.|.|.| ...|| .|
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPkipgDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD----------HGQftHPLIIHCSA
||    ..| .|...|.|.| | . . . |....     .| .|.|...|.. ||| ||| ....||.|..||..           ...  .|...||||
wp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsa

GVGRTGVVISIDSVVAHAkttRmVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLE
||||||..| .. .  .    . ||... |  .|..||. .|||..|| |.| |.||
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 757-1017 8.7e-68 224.3 In-house 29-289 (297) alignment
Range on Protein: 757-1017
Range on HMM: 29-289/297.0
RGRSKMTKEFQTLKSLCPDppashTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSLVLN
 ..... .||..|.|| ||     .. ..   | .|||| . ||. ..||.| .     .|.|||||| ..| ..   .|  || ||| || ||| .| .
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKPSTVVMLNDKSQNDKSCAQYWPDANSvQFGSYSVSTLSTSSDGDMTIRQLKVTRnSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM
.. ...|||..   ... ||||||.  . ..| ..| .|..  ....|.|.|.||. .. |.|||..|..||| ||  |   ...|......|..  .. 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvpp..slellleflelvrealael

-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 ..  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | |.||...|.|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_PTPN13_pd Subfamily PTPN13 477-731 1.1e-67 223.2 In-house 15-269 (273) alignment
Range on Protein: 477-731
Range on HMM: 15-269/273.0
EEFHDLPGPNIY-PQTVAQEEINFTKNRYKNILPYDSARVKLEviDNNPhsdYFNASYIP--SFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVT
|||..|         .|.... | .||||.|.|||| .||||.  |. .   | |||.|     ..   |||.|||   ...|||.|||. ... |||||
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg..degg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLKEGDKIKCGKYWPKIPGDSVKFGN-IKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqFTHPLIIH
. ||..|.|| .|||.. ....|  | ..|||. ..   |   |.....  .  . | |....|..||| |||... .||.|..||.  .   . |...|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||.||.|..|.|| |.   .  . .|| . | ..|..|  .|||..|| |.| |.|| |
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 473-728 1.4e-67 222.7 In-house 5-265 (274) alignment
Range on Protein: 473-728
Range on HMM: 5-265/274.0
ALFSEEFHDLPGpNIyPQTVAQEEINFTKNRYKNILPYDSARVKLEVID-NNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIA
  . .|| .||  |  .|   .   . ||||||.||| . .|| ||  . ... |.| || ||  .|. .|||.| |||     .|||||..||.|. | 
kdlekeflelPl.nf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTKLKEGDKIKCGKYWPKIPGD--SVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHP--
|.||||| .. || .|.|.  .   | ..|..... ..   . .   ||... .  . |.|. . .|.|||. .|.....||....||. .. . ...  
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakla

-LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  ..|||||.||||. |.|.  | . . . .|||.. |.|.|..|  ||||.||| .|. |. 
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_PTPN3_pd Subfamily PTPN3 491-729 1.6e-67 222.4 In-house 34-273 (280) alignment
Range on Protein: 491-729
Range on HMM: 34-273/280.0
TVAQEEINFTKNRYKNILPYDSARVKLEvidNNPHsDYFNASYI----PSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKY
..|.   | .||||..|||||..||||.   ...  || ||.|.    || .  . |||.||| . .. |||.|||......| |.| | |  ..|| .|
saarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPKiPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISI
||. ..|....|...|.. . .. .  . |.... . .  . |...|. ...|||.|||......|.|...|.. .   ..|...|||||.|||||.| .
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.  .|   ... | . . | ..|..|  .|||..|| |.  |.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 498-729 2.1e-66 218.6 In-house 3-237 (237) alignment
Range on Protein: 498-729
Range on HMM: 3-237/237.0
NFTKNRYKNILPYDSARVKLEVIDNNphSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPgDSVK
|  |||| ||  || .|| |.   ..  ||| ||.|. .||   | |||.||| ..| ||||.|||||. . | |.| | ||...|| ||||.   .   
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

FGNIKVELVSLEACTGGIKRKMTMIKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV--KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA
.| . | |   |. .    | ... |     . | . |..|| |||.|||..|..||.| |..  .. | . . | ||||||||||||... ||... .|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|  ..||..|.| .| . |||..||..|| ||. ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0040438 (Phosphotyrosine protein) phosphatases II 741-1018 3.2e-66 219.1 In-house 3-277 (317) alignment
Range on Protein: 741-1018
Range on HMM: 3-277/317.0
VHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDppasHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGI--HCTFMTTQMP
... ..|.||. |.      .. .||..| || .|    ... ..  .|..|||| . ||. ..||.| ..    |.|||||| ..|     .|  || |
ldlllalldllksdf....talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgP

LPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGAR
|| || ||| .| ... ...|||..  .. .. ||||||. .....| ..| .||.  ....|.|.|.|.  ....|.|||.....||| ||  |    .
lpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spd

SLMKLIRAVKSSTNkMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
.| ....||... .  ..  .||||  | ||||.|..|  .. |. ..  ||....|| ||. |.. |||.| | |.||...||| 
llldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 738-1023 5.2e-65 214.6 In-house 2-286 (318) alignment
Range on Protein: 738-1023
Range on HMM: 2-286/318.0
IPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSlCPDPPASHtRSgRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGIH--CTFMTT
|.| .. .|.. |..     |. ....|.. |.  ... ..|. .|  .  |. |||| | |. .. || |.    ... |||||. . | .   ... .
isvedleshvrrlre....sGelllseeyerlsr.seetvtsl.ks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFHGWPKHGSDPQL
| ||| |..||| .| . . ...||| ....   . ...|||. .| ..|.  |   .. . .|...|..||||. .. | .| ||..  || .|.  . 
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

gaRSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
   ||..|.| |..  .| ..  |.||| .| ||||||..    . .|..   ||.||||| ||  |   ||||. | |.|||. |.|.. . |
..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 457-732 5.3e-65 214.2 In-house 2-279 (287) alignment
Range on Protein: 457-732
Range on HMM: 2-279/287.0
IPLAQFPAFVNKNRHT--ALFSEEFHDLPGPNIYP--QTVAQEEINFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYIPSFDNDKAYIASQGPNNA
||. .|  ||.|....    |.. |  |   .  .   |..  . |  |||...||..|  || |.    . | || ||..| .. ..||.|....|   
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKG-VPKHTSS
   .||......|||.| |....|| |. .| .|||.  ..|| .|. ..||.. |  .| |.||. ...    .| ..|.|...|.|...| |... ..
tarnfWkliddrnvtaivmlcqekendeevcyqyWpe..eksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
|| . . .|... .   ....|||..|||... ....  . ..||   .|||. . . |...| .||| ||| ||. .||| | 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 457-730 2.6e-64 211.9 In-house 2-282 (290) alignment
Range on Protein: 457-730
Range on HMM: 2-282/290.0
IPLAQFPAFVNKNR--HTALFSEEFHDLP-GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPH--SDYFNASYIPSFDNDKAYIASQGPNN
||. .|  || ...   .  | ..|. |  | . .  ||.  . | ..||..||..||  |. |  | ...    .| ||.||  . ..|.||| ||| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDD---YRTVTQFHFTEWPDKG-VPKHTS
    |||...|||.|| | |.|. .| .| || .|||.   |. ..|.....|.. |.... |.||. . . .     ..|||...| |...| |.....
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

SLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
.|| . . .|  . .  .....|||..|||..| ....  . ..||.  .|||. . . |...| .|||..|| .|.  ||. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 770-1020 6.9e-64 210.9 In-house 29-286 (305) alignment
Range on Protein: 770-1020
Range on HMM: 29-286/305.0
KSLCPDppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLN-DKSQ
|||. .   . .  |..  |. |||. .. .|. .|.||      .|.|||||| ..| .   .....| ||..||.||| |....|.||.|||   . .
kslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveg

NDKSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCL
... | ||||.. .   .||..||   |...  | ..|.||..   ..| |.||.|||.  || ||  ||  | ||..||. |. . .| .. ..|||| 
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGv.pqf.atsllslikrvqkdqkkdkgvpllVhCs

SGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 | ||||||..    . .. . ..||.|. .| ||  ||. ||| ..| |..|.. |.... 
agvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0045450 (Phosphotyrosine protein) phosphatases II 758-1017 9.7e-64 211.3 In-house 25-304 (307) alignment
Range on Protein: 758-1017
Range on HMM: 25-304/307.0
GRSKMTKEFQTLKSLCPDPpASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKG----------IHCTFMTTQMPLPTTVSDF
..... |||..|.|.....   ......   |..|||| . ||. ..||.| |     .|.|||||| ..           .  .|. || ||| || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSLVLNYKPSTVVMLNDKSQNDKS-CAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLI
| .. ... ...|||..   ...  ||||||| ... ..| . | .||.. ....|.|.|.||.   .. |.|||.....||| ||  |     .| ..|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldfi

RAVKSSTNKM-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
..|..  ..  ..  .||||  | ||||.|..|  .. |. ..     ||....|| ||. |.. ||..| | |.|....|.|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0043336 (Phosphotyrosine protein) phosphatases II 740-1017 1.3e-63 210.4 In-house 4-277 (278) alignment
Range on Protein: 740-1017
Range on HMM: 4-277/278.0
VVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPdppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGI--HCTFMTTQM
| .. ..|..|. ..  .    . .||..| |  .     ... ..  .|..|||| . ||. ..||.|.. .    .|||||| ..|     .|  || 
vkdllkallelllnlktl....lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqg

PLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPdANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGA
||| || ||| .| ... .|.|||..   .. . ||||||  .|...| ..| .|.. ...|.|.|.|.||.  .. |.|||.|...||| ||  .    
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..sl

RSLMKLIRAVKSSTNkMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 .|.....||..  .  ..  .||||  | ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | |.|....|||
sllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

Y_phosphatase Protein-tyrosine phosphatase 789-1013 2.4e-63 209.0 Pfam-A 1-233 (235) alignment
Range on Protein: 789-1013
Range on HMM: 1-233/235.0
NHPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWP--DANSVQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| .|...| ...|||..  . ... ||||||  . .|...|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSTL-STS-SDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTnKMNEFSILVHCLSGAGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||   .  ..||..|||.|..|. . .. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 ....||..|.|| ||. |.. ||..|.|.|.|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 789-1013 2.4e-63 209.0 In-house 1-233 (235) alignment
Range on Protein: 789-1013
Range on HMM: 1-233/235.0
NHPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWP--DANSVQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| .|...| ...|||..  . ... ||||||  . .|...|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSTL-STS-SDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTnKMNEFSILVHCLSGAGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||   .  ..||..|||.|..|. . .. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 ....||..|.|| ||. |.. ||..|.|.|.|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPN23_pd Subfamily PTPN23 492-730 3.8e-63 208.0 In-house 37-279 (288) alignment
Range on Protein: 492-730
Range on HMM: 37-279/288.0
VAQEEINFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYIPSFDND-KAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKI
.|  ... .|||...|||||..||||.    . . || |||.. .       .||.|.| . .  |||.||... . .| |... .| .| |. .|||. 
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

PGDSVKFGNIKVELVSLEACTGGIKRKM--TMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA----DHGQFTHPLIIHCSAGVGRTGVVISI
 |..||||...| | | .     ..|..  .. . |  ..|.  ..|.||. |||.  ..||.|..||..     . .   ||..|||||||||||.  .
kgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 ..|.   |   ..|. . |  .|..| .|||..||. | | |||| 
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 755-1015 8.1e-63 207.2 In-house 16-277 (288) alignment
Range on Protein: 755-1015
Range on HMM: 16-277/288.0
DGRGRSKMTKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLN
. |.|. ...|...| .|      . .  ||   |..|||| | ||.  .|| |.     .. |||||| ..| .   ....|| ||. || ||| || .
sarnrtgfseeynsLaalek...tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YKPSTVVMLNDK-SQNDKSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVTrNSKTSHTVTQYQFHGWPKHGsDPQlGARSLMKLIRAVKSsTN
.| ||.|||..   .... | .|||||.  ...||  |  ...   .|.. |.| .   .||  ..||||. .|| ||  |.  .. |..|.| ||  .|
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhg.vPe.skapllellrqvkv.an

KMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
. .   |.|||  | ||||.| ..   | .. | | .|.. ||. ||  |...|||.. | |.|.|. .
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 735-1021 4e-62 205.1 In-house 2-287 (319) alignment
Range on Protein: 735-1021
Range on HMM: 2-287/319.0
NTLIPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSLCPDppasHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTF
.| |.| .. ..|. |.|     |  .. |||..||   .|    ...|  . .|..|||| | |. .| ||.|    .... |||||| . | .    |
dteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekf

MTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTS--HTVTQYQFHGWPKHGS
. || || .|..||| .| ... |.||||.. ... |  . .|||..| ...| . |  ..     |. ||.||. ..|      .|...|.  || |. 
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv

dPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 |.  |.||..|.. .. |..| ..  | |||  |.|||| |..    . .. |   .|.|.||. ||. |   ||..| | |.|....|.... .
.Pek.atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 784-1019 8.2e-62 203.6 In-house 4-244 (250) alignment
Range on Protein: 784-1019
Range on HMM: 4-244/250.0
GRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDKSCAQYWPDANSV
..  .|. |||| . ..|.  ||.| . .     |||||| ..| .   .|..|| ||..|. ||| .||..| .|.|||.. ....| . ||||  .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQ
..|.  || ||.   .|.|.|.||.....|... .| |..|  ||  |  |.  |.. ..|.. |..| .. ..  ..|.| .| ||.| |..    . .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv.Pev.atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
. .   ||.|. .|.||.||.. |...| | ||| .| ..| .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_PTPRB_pd Subfamily PTPRB 738-1021 2e-60 199.3 In-house 7-289 (293) alignment
Range on Protein: 738-1021
Range on HMM: 7-289/293.0
IPVVHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDPPAShtrSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTT
| . .|..|......  |     ....|...||..  |   .   . ..  |. |||| | || . .|| |    |... |||||. ..| ..   |..|
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqavk...aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRnSKTSHTVTQYQFHGWPKHGSdPQl
| |||.|| ||| .|.. | |..||| .   . |  | .|||.  ..|..|. .|. .....  | .||.||... .|....|.||.|  || ||  |. 
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgv.Pe.

GARSLMKLIRAVKSST-NKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 ...|....|.|.... .....  |.||| .| ||||.| .  . . .| | | |||| .|  || .|...||||..| |..... ..|....
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_PTPRK_pd Subfamily PTPRK 785-1015 2.5e-60 198.9 In-house 39-275 (314) alignment
Range on Protein: 785-1015
Range on HMM: 39-275/314.0
RTRDNHPKNRYGNNLPLQRNRVILDSPDHD----YINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDANSV
.  .|. |||.|. |.  | ||.| . | |    ||||. . . .    |. || ||. || ||| ||.... ...|||..  ..    | .|||.  .|
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

qFGSYSVSTLSTSSDGDMTIRQLKVTR---NSKTSHTVTQYQFHGWPKHgSDPQlGARSLMKLIRAVKSSTNKmNEFSILVHCLSGAGRTGVFCTAMECI
 .|   |  ..|. . .. .| ..|..   . .  ..| |.|| |||.|   |.  |..|.||.| ||.|... ..  |.|||..||||||.|..    .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPv.satgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  | . . ||.|..|| ||. .. .|.||| | |.|||| |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

0045098 (Phosphotyrosine protein) phosphatases II 776-1018 7.7e-60 198.0 In-house 20-273 (278) alignment
Range on Protein: 776-1018
Range on HMM: 20-273/278.0
PPASHTRSGRTRDNHPKNRYGNNLPLQRNRVIldspdhDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDA
.. |    .  ..| .|||| . ||. ..||.      |||||| ..| . .|  || |||.||.||| .. ... ...|||..  ..  . ||||||. 
gipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-----NSKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTN---KM---------NEFSILVHC
.|...| ..| .||..  .|.|.| |.||      .. .|..||......|| ||. ..   .|. .|.. ...  .   ..         ..  .||||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

LSGAGRTGVFCTAMECIAQIaeGDSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYLH
  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | |.|....|.|.
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 470-742 1.3e-59 196.4 In-house 6-277 (283) alignment
Range on Protein: 470-742
Range on HMM: 6-277/283.0
RHTALFSEEFHDLPGPNIyPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNnphsDYFNASYIP---SFDNDKAYIASQGPNNASTDDFWRMVWQENV
    || | .. |  |.  . ..|  . | .|||...|.|.|  ||.|.   .    || ||..||   | ..|| ||..|.| .    |||.||..|..
nnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

TTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF
|.| |.|||.|. .||| .||||    |...|.  | |    .    |...... .     .   .. . . .| . |      ||.|| | .     . 
taivmltklqedlrikCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVH
  |...|||.|.|||.| |.. . | .|.|  .||||. |...|..|. .|||..|| ... .|||. |  .| |  | 
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 467-745 2e-59 196.2 In-house 15-293 (439) alignment
Range on Protein: 467-745
Range on HMM: 15-293/439.0
NKNRHtALFSEEFHDLPG--PN-IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQ
.||..  .|.|.|. .    |.     ..| .| . ||||||.. ..| .|| |. |   ||| |.|| ||  . .|| |||.|||.. .||||||.|..
dknkq.eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

ENVTTIAMVTKLKEGDKikcgkYWPKipGDSVKFGNIKVELV---SL-EACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-A
....|| |.|.| |  |     |||    . | .|.| |       | . .  |.|      ...  ||| |||.. |||| || ..| .|.|.. .. |
kktvtivmltnlvesyk.....ywps..daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa

DHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTD
.  . . |...|||||||||| .|..|  . . |.   ||.   |. .|..|  |||.  || ||| |||||. . .. . . .|  
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk

0040439 (Phosphotyrosine protein) phosphatases II 784-1017 3.1e-58 192.7 In-house 6-246 (249) alignment
Range on Protein: 784-1017
Range on HMM: 6-246/249.0
GRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANS
..   |..|||| . ||. ..||.| .    ...|||||| ..|  |  .|  || ||| ||.||| .. ... ...|||..  ..  . ||||||. .|
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

VQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKM-NEFSILVHCLSGAGRTGVFCTAMECI
...| ..| .||. . .|.|.|.|..|.   ..|.||...|...|| ||  |     .|...|.||..  ..  ..  .||||  | ||||.|..|  ..
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvpps..fedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 |. .   ||....|| ||  |.. ||..| | |.|....|.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPN14_pd Subfamily PTPN14 491-729 3.4e-58 192.0 In-house 42-294 (300) alignment
Range on Protein: 491-729
Range on HMM: 42-294/300.0
TVAQEEINFTKNRYKNILPYDSARVKLEVIDNNpHSDYFNASYIPS--FDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
..|. . |  |||.|..|||. .||.|    .| ...| ||| |      ... ||..||| .    |||.|||...|. |.|.|. .|. | |. ||.|
staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

KI--PGDSVKFGNIKVE--LVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF---------THPLIIHCSAGV
|     ..|.||. ||   ...   ..  .. |.  .   ..|||  . .|.|||.|||.  .. |....||..   ..           |...||||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

GRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|||||.|  | ..|  .. . .|. . .. .|..| ..|||  || |.| ....
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPRN_pd Subfamily PTPRN 490-730 2e-57 189.2 In-house 48-291 (297) alignment
Range on Protein: 490-730
Range on HMM: 48-291/297.0
QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
..||..| | .|||.|..|||| .||||.   .. .||| ||| |   |    ||||.||| ...  |||.|||.. |. | ..|.|.| .  .| .|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

KIpGDSVkFGNIKVELVSLEA-CTGGIKRKM--TMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISID
.  | .| ..  .|.|||    |   . | .    .. .. ||||||||  ||..|||  . |||.| . |   .   . |...|||.|.||||| | ||
de.Gsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SVVAH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 |... .|  . .|.   .  .|..|| .|.|..|. |...|| |.
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

0042113 (Phosphotyrosine protein) phosphatases II 785-1017 5.3e-57 188.4 In-house 5-243 (245) alignment
Range on Protein: 785-1017
Range on HMM: 5-243/245.0
RTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANSV
.   |..|||| . ||. ..||.| ...    .|||||| ..|     .|  || ||| || ||| .. ... .|.|||..   ...  ||||||. .|.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

QFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSStnkMNEFSILVHCLSGAGRTGVFCTAMECIA
..| ..| .||. ...|.|.|.|.||.  .. |..|..|....|| ||  .      ......| . ..    ..  .||||  | ||||.|..|  .. 
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmle

QIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|. .   |.....|| ||  |.. |||.. | |.|....|.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPRG_pd Subfamily PTPRG 738-1023 7.9e-57 187.7 In-house 1-293 (563) alignment
Range on Protein: 738-1023
Range on HMM: 1-293/563.0
IPVVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPDPPAsHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-PD----HDYINASQMKGIH--CTFMT
.|| .|. |. .||..|| .    ...||. |.| . .    .. . . ..|. |||| | .. .| || | . |.    .|||||. ..| .    |..
vpvkefakhvaslhadgdig....fseefealqsetiskdl.daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDANSVQFGSYSVS-----TLSTSSDGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPK
|| ||..|. ||| .. . . ...||. . . .. . | .|||  .|...|. .|      .|....   ..|..||. ....  | ..|.||..  || 
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGSdPQlgaRSLMKLIRAVKSSTNKMNE-FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||. |.    ||..|| ..|||. ...|   |.||| .|.||||...     . || . ..|..|...| .|| |   |||||.| |..|.. | . ...
hgv.Pe...hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

YE
 |
te

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 737-1019 1.1e-56 186.9 In-house 1-285 (290) alignment
Range on Protein: 737-1019
Range on HMM: 1-285/290.0
LIPVVHFTDHLQdlhsSGDGRGRSKMTKEFQTLKSLCPDppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPD--HDYINASQMKGI--HCTF
|||| .|.....     |  .|.... ..|..|.|   .     .  | | .|...||. | .. . ||..|      .|  ..||||. .||   .  .
lipvdkfgefva....nghakgnegfrnqfkmldsgese...htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy

MTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPKHGS
. || |.. |. |||.|. . | . .||| . .... . | |||||... ..| .|.  |. ..  ....|.|.|. ...  ....|||||.  |...|.
iatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgk

DPQLgARSLMKLIRAVKsSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ..  . .|. . . .|    |  . ||.|||  . ||..|||.|.  | .      .|.|| .| .|  ... |||...| ...... .||..
vtnp.qtillvieemyk.tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_CG7180_pd Subfamily CG7180 468-732 1.9e-56 185.9 In-house 12-291 (296) alignment
Range on Protein: 468-732
Range on HMM: 12-291/296.0
KNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVT
.... ...  |..  |  .|     . .. |  |||. ...||| .|| || .| . .||| ||.|. ||  .|.||  ..| . . |.|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIAMVTKLKEGDKiKCGKYWPKIPgdSVKFGNIKVELVSLEACTGGIKRKMTMIKG------------DDYRTVTQFHFTEWPD-KGVPKHTSSLLKFIK
.. ..||  .  | .. .|||.      ..|.| ||.|. .  .   .|.. . |              . |.|..|..|||.  . ||  |..|.....
avvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

EVKADHGQF-----THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
 |.   ..      . |.....| |..|.|| ..||  .  .. .  ||||..|  .|..|| .|.. |.| .||  .|| .|
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_PTPRA_pd Subfamily PTPRA 779-1018 4e-56 185.3 In-house 48-297 (330) alignment
Range on Protein: 779-1018
Range on HMM: 48-297/330.0
SHTRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYW
.        .|. |||. | || . .||||      .. |||||| ..| .   .|...| |.  || ||| .. ..| .|.||| . | .... |||||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PDANSVQFGSYSVSTLSTSSDGDMTIRQLKVT-----RNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEfSILVHCLSGAGRTGV
||  .| .|   |.   .    |.|.|.. |.     .. |.|  |.|. |..||. |  |   .. ..||...||.  ... . .| ||| .|.|||| 
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv.Pf.epiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGt

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY-LH
|..    ....     ||.|..|| ||. | | |||.| | |.| |..|| |.
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly

subfamily_PTPN6_pd Subfamily PTPN6 743-1021 1.2e-55 183.7 In-house 9-301 (306) alignment
Range on Protein: 743-1021
Range on HMM: 9-301/306.0
FTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPAShTRSGRTRDNHPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMK----GIHCTFMTTQMPL
  .. ..|. ...  ... ...||..|.        |  . |.  .|. |||| | ||   .||||   . |..|||||...|    | ......||  |
ieqrvselekeeeslekagfeeefeelqqeeakklls.rkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl

PTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVT--RNSKTSHTVTQYQFHGWPKHGSDPQLGA
.|||||||..|.. .   .||.  .     . ||.||||...  ..|..||...| .|  | ..|.|.|.  ...|....| ||.|. || ||   . ||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpga

R-SLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQI---AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
  .... ... ......... .|.||| .| |||| |      . .|        .|| ..||..|. | ..||||. | ||| .|..|..|..
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_PTPN1_pd Subfamily PTPN1 487-730 1.3e-55 183.1 In-house 21-270 (290) alignment
Range on Protein: 487-730
Range on HMM: 21-270/290.0
IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNnphsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKY
 .|...|... | ..|||... ||| .|.|||  ||    || ||| .   . .. || .|||    .| ||.|||...  .. |. |. | ..||| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPKIPG-DSVKFG--NIKVELVSLEACTGGIKRKMTM--IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhGQF---THPLIIHCSAGVGRT
||.    .....   ..||.|.| |     . |.. .  .| .. |....||.| ||| |||.  ...|||. .|.   | .     | .||||||.||.
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGpavihcsaGiGrs

GVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
| .. .|..... . .     ||. . . ..|. |  ..||..|  | | |.|| 
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 746-1021 1.6e-55 183.1 In-house 6-282 (287) alignment
Range on Protein: 746-1021
Range on HMM: 6-282/287.0
HLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPpASHTRsGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFW
.. ..  .|  .|.   .. |..|...  ..  . |  . . .|..|||. . |. . .||.|   ..|||||. ..| .    |. .. |.  |. .||
kfgefvakghakgnegfknqftvleqvtqre.devth.niasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

SLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQLgARSLMKLIRA
 |. . .....||| .. .| .. | ||||. .|| .| |... |.     ....|.|.|....|.   ..|.|||.  |...|  ..  . .|. . . 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieem

VKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.|.   |  . ||.|||  . ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| |..|.. |||.. .
yktq.rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 909-1021 1.7e-55 183.1 In-house 171-280 (515) alignment
Range on Protein: 909-1021
Range on HMM: 171-280/515.0
SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.||||..|..||..|....  ..||.|||..||....... .....||..|.|||||........|.......||.|..|...|..|...|||.|.|||
srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

VYDVIREYLHTEN
.|....|.|.  |
iygavledllwrn

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 469-730 3.1e-55 182.0 In-house 11-292 (301) alignment
Range on Protein: 469-730
Range on HMM: 11-292/301.0
NRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDN--NPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENV
. |.  |.|....|   .  . ||  .| | . ||.||| .||  |. |.   |    . .| ||||| .. . |..||.||| .    ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLE-----------------ACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSL
..| |||.|||| | || .|||.   .| .||...|.||.                   .  | |.||. . .  . ..|.|.. |.||. || .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFIKEVK-ADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
|. | .|  . .     |...|||..|.|.|| .|..  .  .|    ||||. .  .|...| .|.| ||| .|| .. . 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 772-1021 3.3e-55 182.5 In-house 32-292 (325) alignment
Range on Protein: 772-1021
Range on HMM: 32-292/325.0
LCPDPPASHTRSGrTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK
| .| . ... ..   .|  |||. | ..|...||.|    |.|. |||||| ..      .|...|.||..|. |.| |||... | ||.||   ....
lpsddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkd

SCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT-SHTVTQYQFHGWPKHGSDPQLG-ARSLMKLIRAVKSS--TNKMNEFSILVHCLS
.||.|||.   .|..||.  |.  .     |   |.|.| . .|  . .| |.|. .|.  | . .     |...|. ||.    .|      ||||| .
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
| |||||| .    .|.. |  .||||. || ||.|| . |.| ..| ..|. . |.. . |
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn

0037934 (Phosphotyrosine protein) phosphatases II 787-1017 7.5e-55 181.5 In-house 8-242 (243) alignment
Range on Protein: 787-1017
Range on HMM: 8-242/243.0
RDNHPKNRYGNNLPLQRNRVILdsPDHDYINASQMKGIHcTFMTTQMPLPTTVSD----FWSLVLNYKPSTVVMLNDKS-QNDKSCAQYWPdaNSVQFGS
  |..|||| . ||. ..||.|  ...|||||. ...   ..  ||.||| || |    || .. ... ...|||..    . . ||||||  ..|..| 
penlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygd

YSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSST----NKMNEFSILVHCLSGAGRTGVFCTAMECI
..| .||... .|.|.| |....   .. ...|..|....|| ||  .      .... .|.. ...    .  ..  .||||  | ||||....|  ..
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

AQIaegdSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYL
 ..    .||....|| ||. |..  |||.. | |.|....|.|
lll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 758-1019 1.2e-54 180.2 In-house 6-279 (290) alignment
Range on Protein: 758-1019
Range on HMM: 6-279/290.0
GRSKMTKEFQTLKSLCPDPPASH---TRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLN
|. ...||||.||.|     |..   | .|..  |  |||| . || . .|| |     ... |||||. .||   ..... .| |||.|..||| .. .
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

YKPSTVVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSS-DGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSS
.. . |||.  .  ..|  |..|||.   ....||...|.. .    | |..||.|||... |.|..|.|.... || ||  |. .| ||..||..|.. 
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgv.Ps.saksllelielvrel

TNkMNEFSILVHCLSGAGRTGVFCTA---MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 .  ..  ..||| .| ||||. ..     | . .    ...|.|. |  || .|   |||.| | .||  . |....
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_Ptp69D_pd Subfamily Ptp69D 762-1021 2.3e-54 179.6 In-house 24-290 (307) alignment
Range on Protein: 762-1021
Range on HMM: 24-290/307.0
MTKEFQTLKSLcpdPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
..||...|..         |. .   .|  |||| .  .  ..||.|       | |||||| .||   . .|.. | |. .|. ||| .. . .  ..|
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSK------TSHTVTQYQFHGWPkHGSDPQLgARSLMKLIRAVKSsTNKM
|| . .. ..  ||.|||. . ||.|.  | . |... .| .||.|.|... .       |. |.||.. ||.     |.  ||.|.|||. |..  .|.
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPev.argllklieqvre.lykl

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
|.  |.|||  |.||.|.| .    . |. . |.||||.||| || .|  .||  | | |.|  . .| .  .
nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd

subfamily_PTPN23_pd Subfamily PTPN23 757-1019 7.5e-51 167.6 In-house 12-282 (288) alignment
Range on Protein: 757-1019
Range on HMM: 12-282/288.0
RGRSKMTKEFQTLKSLCPDPpASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSLVLNYKPST
 |.... |.|. |..      | ..     . .  |||. . ||  .||| |..   |||||| .|..     .|..|| ||..|..|||..| . | |.
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

VVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKS---STN
.||| .|.. .| ....||| .  ..|.|| .||.  |. . . .  |.||.. . ... ..|.  |.. ||..|  |.    .|.... .|.|   ...
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGv.Pa.sPetllqfldevesayeavq

KMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.  .  ..|||..| ||||||.  .  .... .|. . || | |. ||..|   ||..|.. |.|... |. . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 783-1015 8.6e-51 167.7 In-house 43-277 (315) alignment
Range on Protein: 783-1015
Range on HMM: 43-277/315.0
SGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDKSCAQ-YWPDAn
  .   |. |||| | ..  . || |      |. ||.||. ..|      ....| |....| ||| || ... ...|||..  ...|. |. ||||  
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSdpQLGARSLMKLIRAVKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIA
 | .| ..|.  |     ..|.| | |. ...  ..| |...  ||. |      . .||.||| ||   .. .  .|.||| .| |||| |.|    . 
kviyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqh.htnsvgaivvhcsaGvGrtGtfitldavld

QIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|.   . .|... .. .|. |.. ||. |.| |.||.. |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 493-728 1.5e-50 166.6 In-house 33-274 (287) alignment
Range on Protein: 493-728
Range on HMM: 33-274/287.0
AQEEINFTKNRYKNILPYDSARVKLeVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpG
|.|  .  |||| ..||.| .|| | . . .  ||| || |..|. .|.|.||.|||  |.  ||||.|...........|.  |  . || ||||.   
aeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.e

DSVKFGNIKVELVSLEACTGG-IKRKMT--MIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV-----KADHGQFTHPLIIHCSAGVGRTGVVISI
  .. |   | |.. .        | .    ... . | | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|.....
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  .|   . .  ||| . |  .|..|  .||.  |. ..| |. 
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 777-1015 1.6e-49 163.3 In-house 21-264 (283) alignment
Range on Protein: 777-1015
Range on HMM: 21-264/283.0
PASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK-----GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKS-QNDKSCAQY
|  ..    ...|..|||. . .| ...|| |.|  .|||||. .           .. .| ||  || ||| .| . | ...|||     .... |.||
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLiRAVKSSTNKMNEFSILVHCLSGAGRTGVFC
||   |...| . |.     .   ..|..| .  |  .|..  .. ||. .| . | .. .   ||.|.   |.|  .. ..  |.||| .| |||.||.
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaii..nslvkf.nkvislqteskkgPivvhCstgiGrtavfi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
.|.  . ..     ||.|..|||.| .||  ||| . | .|.... |
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 761-1018 2.1e-49 163.5 In-house 35-293 (319) alignment
Range on Protein: 761-1018
Range on HMM: 35-293/319.0
KMTKEFQTLKSLCPdpPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTV
|.  ||. .  | .  . .        .|  |||..| |.  .|.| |.  .     |||||| ..|      ....| ||. |. ||| .. .|. ||.
klevefrracklgv..nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLNdksqnDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNKMNE-F
|.|       . |.||||    .. . . |.  |     . ..|.......   |    .||. | |||..|  |. ..  ||.|.. |.  |.|.|.  
vllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGv.pdyps.dlmrlvkkvrhltskenhra

SILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
.|.||| .|.|||||. .    . .. | . ||....|. || .| ..||   .| |.|  . | .| 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 761-1019 4.5e-49 162.1 In-house 16-278 (281) alignment
Range on Protein: 761-1019
Range on HMM: 16-278/281.0
KMTKEFQTLKSLCPDPPASHTrsgRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTV
 ...|...|...  | .|. .   .. .|  |||| |       || .    .. . |||||. ..|..    ...|| |.|... .|| .|...| |..
Gfieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLNDKSQNDK-SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEFS
||.  . ...|  | .|||| | ....| . |.......   .  |..|..|.|  . .|.| ..  || ||  |.  .. |..  ..|.. |.| .. .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGv.Pa.ttkellefrkevlkltekktkap

ILVHCLSGAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
...|| .| ||||.. .    . ... |  ..|. ..|. || .|. .|||   |.||| .. ..|. 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_PTPN9_pd Subfamily PTPN9 748-1017 1.1e-48 160.8 In-house 4-290 (297) alignment
Range on Protein: 748-1017
Range on HMM: 4-290/297.0
QDLHSSGDGRGRSKMTKEFQTLKSlcpDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGI--HCTFMTTQMPLPTTVSD
..| .    .|.. ..||.. ...    |..      ..| |  |||| . | ... || | .       |||||. . |   . .|..|| ||. ||||
eelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWSLVLNYKPSTVVMLNDKSQND-KSCAQYWP--DANSVQFGSYSVSTLSTSSDGDMTIRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKL
|| .| . .  ..||     ..    |.||||  . .| .||..|||.... .  | ..|.|...  . . | .|| .|| .|| .|  |.  | ||...
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGv.Ps.saaslldv

IRAVKS------------STNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
...|..            .. ....  |.||| .| |||| |.|   |.... | . ||...||| ||. |   .||.| |.| |  . || 
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 785-1018 1.3e-48 160.9 In-house 21-257 (284) alignment
Range on Protein: 785-1018
Range on HMM: 21-257/284.0
RTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNdksqnDKSCAQYWPDANSVQ
   .|  |||.|. |.  .|.| |.  .     |||||| ..|      ...|| ||. |. ||| .. .|. ||.|.|      .. |.||||    ..
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivik

FGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNKMNE-FSILVHCLSGAGRTGVFCTAMECIA
 . . |.  | .   ....|.......   |   ...|. | |||..|  |. ..  ||.|.. |.  |.|.|.  .|.||| .|.|||||. .    . 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgv.pdyps.dlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

QIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
.. | . ||....|. || .| ..||   .| |.|  . | .| 
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

subfamily_CG7180_pd Subfamily CG7180 759-1018 4.8e-48 158.3 In-house 12-291 (296) alignment
Range on Protein: 759-1018
Range on HMM: 12-291/296.0
RSKMTKEFQTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPS
| |.  |.. .  | |     . . |   .|  |||. . .|   |||.|..     . |||||. . .      .. |..|   || .||.|| . . |
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TVVMLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-----------SKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAV
.||.| .. .  | . .|||     |.|   | .... .  ...||..|.|..           .    .|...|.  |. . . |   . .|..|.| |
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPls.tnalielrrrv

KSSTNKM----NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
..  .|.    .|  ..|..  ||.|.||....  .. .. . . ||.|. || || .| | |.. ||| ..|||. |.. 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

0051429 (Phosphotyrosine protein) phosphatases II 524-730 2e-47 157.4 In-house 2-224 (272) alignment
Range on Protein: 524-730
Range on HMM: 2-224/272.0
PHSDYFNASYIPSFDN---DKAYIASQGPNNASTDDFWRMvWQENVTTIAMVTKLKEGDKIKCGKYWP----------KIPGDSVKFGNIKVELVSLEAC
| |.|.||.... . .   ......|.|| ... .||||. ......|| ..... | .. || .|||               .. .|.. | |.| | .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TGGIKRKMTMI---KGDDYRTVTQFHFTEWPDKGVPKHTssLLKFIKEVKAdhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVD--------V
.  | |.....   . ...|.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ...    . .||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
...|  .|..||..|||.|||.|.| |.|| 
eeaveelraqrpgavqteeqylflyeallel

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 777-1018 2.4e-47 156.3 In-house 15-269 (274) alignment
Range on Protein: 777-1018
Range on HMM: 15-269/274.0
PASH-TRSGRTRDNHPKNRYGNNLPLQRNRVIL-----DSPDHDYINASQMKGIH---CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKS
|. . ..  .   .. |||| . || .. ||.|     ...| .||||  .|| .    ... || |||.||.||| .. . . . .||| . | .| . 
PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk

CAQYWPDANSV----QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKtSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNEF--SILVHCLSG
||.|.|||...    ..|  .. . .. .  | ..|.| .   .. ...|. | .  || | |  .  |..|..|.. |..| .. |.   ...||| .|
CavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
 ||||.| ..  .. |. |   ||....|  || ||   |||.| | ... .. .||.
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_PTPN3_pd Subfamily PTPN3 777-1014 1.1e-45 150.7 In-house 29-272 (280) alignment
Range on Protein: 777-1014
Range on HMM: 29-272/280.0
PASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK------GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQ
|  ..   |  .| .|||| . ||    ||.|.. . |||||. ..      |.   ...|| ||..|..||| .| . | |..||| .  .. .  | |
pglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEfSILVHCLSGAGRTGVF
|||.  .....|..||   .....  . .|.| ..... | .....| |.  || ||  |.  . ....... |..  . ..|  ..||| .| |||||.
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgv.Pd.dsadflefvervrklrsgkee.PvvvhCsaGigrtGvl

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
 .   ..| | . ..| . . |. .|  |. .|||.. | || . | 
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

0041856 (Phosphotyrosine protein) phosphatases II 498-739 1.7e-45 150.2 In-house 1-179 (182) alignment
Range on Protein: 498-739
Range on HMM: 1-179/182.0
NFTKNRYKNILPYDSARvklevidnnpHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTklkegdkikCGKYWPKIPgdsvkf
|..||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|         .  |||.        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gnikvelvsleactggikrkmtmikgddYRTVTQFHFTEWPDKGVPKhTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrMV
                            .|...|.... ||| |||  ...||.||.||..      .| ..||||||||||... .. .  .      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIP
.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk

subfamily_PTPN13_pd Subfamily PTPN13 763-1018 5.2e-45 148.8 In-house 14-270 (273) alignment
Range on Protein: 763-1018
Range on HMM: 14-270/273.0
TKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHdYINASQMKGI----HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLN
..||..|. | |     ....|....|. |||| | || .. ||.|..    ||||| .|      . ... .| |||.||.||| .| . | . ..|. 
aeefkelrelkp...ldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

-DKSQNDKSCAQYWPDANSVQFGS---YSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmNEFSI
 .| ..   | .|||. .. .      . |. | .    ....|.|.|.  .|. |. |.. .|  || ||   .  | .|..... |..  .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPi

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
.||| .| ||.|.. |    .  |.   ..|. ..|. ||  |   |||.. | ||| .| | |.
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 475-728 4.5e-44 145.2 In-house 13-266 (281) alignment
Range on Protein: 475-728
Range on HMM: 13-266/281.0
FSEEFHDLPG-PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEV-IDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMV
| .|| .||| |     || .. .|  |||| ||   | .||.|.| . |.  .||  | || |    . || .|||.. .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCS
 .. | .. || .|.|.     ..| .. |.          .  .. .    . | .|.. . ||||  ||. .  .|| .....|     . | .||||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRTGVVISIDSVVAHAKT-TRMVDVFNFVTNIRQ-KRPYMVQTQEQYAFIYGAVL
|||||.| .....  .   ..   . |. . |. .|   |   ||| .|| .|.  .|
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 789-1020 5.1e-44 145.3 In-house 20-267 (270) alignment
Range on Protein: 789-1020
Range on HMM: 20-267/270.0
NHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG---IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDANSV---
..  ||| . ||  . ||.|..    .   ||||  ..|    ........ |||||...|| .... | ...||. . . .. | |..|||  .     
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSDPQLG----ARSLMKLIRAVKSSTNKMNEF-SILVHCLSGAGRTGVFCTAM
 ..|  .| .||.. .    ...|........ . .. .... || ||  .. .    ...|.|..|||. |......   .||||  | ||||.. .  
ledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 ..  . |  .||. . .. || |||..||. |.|.|.| ...|| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

0036282 (Phosphotyrosine protein) phosphatases II 526-724 1.1e-43 144.3 In-house 2-163 (174) alignment
Range on Protein: 526-724
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNDKAYIASQGPNNastddFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipgdsvkfgnikvelvsleactggikrkmtmIKGDD
|||.|||..  .   . .||.||| .     ||.|......||. |....|| .. ||  |||                                 . | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

YRTVTQFHFTEWPDKGVPKHTSsLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKtTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.|.. |.... ||| |||  .  ||.|.|.|.  . .   .|...||||||||||... .. .  . . ...||....|  .|..||.||||..|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly





subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 477-732 2.1e-43 143.5 In-house 20-278 (307) alignment
Range on Protein: 477-732
Range on HMM: 20-278/307.0
EEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVidNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLK
.||. |   .    ||   . |  ||||...   | .|. ...  .   |||  | |.    . | .|..||| ...  .|| |. ||.| .. |. |. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EGDKIKCGKYWPKIPGDSVKFGNIKV--ELVSLEACTGG-----IK-RKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLI
|  |||| .|||   |.   ||.      .  | | .       |.  .. .  ... ||.... ...|||.|||.   . . ... |. |    | |..
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvv

IHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
.||||||||.| ...|  |     .     |. ..| ..|..|.| .||. || ...  .|| .|
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl

subfamily_PTPN14_pd Subfamily PTPN14 779-1018 7e-43 141.7 In-house 39-297 (300) alignment
Range on Protein: 779-1018
Range on HMM: 39-297/300.0
SHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP---DHDYINASQMK----GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQY
... ...  .| .|||. . || . ||| | .    ...|||||..|    | . .....| ||..|| ||| .| . . . .||| .. .. |  . .|
allstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDA----NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQL-GARSLMKLIRAVKSSTNKMNE-----FSILVHCLS
.|.     ..|.|| . |.|  ... . .. ..||.    ||   ||   |.  ||.||  . . |  | .. ...|.  ||...|       .||||. 
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
|.|||||  ..   || .  ....|| .....||  || .|||   | |||.|. .||.
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 762-1021 1.1e-42 140.7 In-house 17-297 (301) alignment
Range on Protein: 762-1021
Range on HMM: 17-297/301.0
MTKEFQTLKSLCPDPpashTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP------DHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPST
. .....||.  ...    .  | . .|.. ||. |. ... ||.||          ..||||| ..|.     |. .| |.  |. ||| |....||..
feeqykelkegedks....ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

VVMLNDKSQN-DKSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLKVT----------------RNSKTSHTVTQYQFHGWPKHGSDPQlgARSL
.||. .. ..  ..| ||||...    .||  .|   ..    |..||||.|.                ...|.|..|.|.|   ||..|  ..   |  
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre..prtv

MKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.. |  |   ..|..   ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | ..|||| .||. ..
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 495-732 1.8e-39 130.2 In-house 52-290 (305) alignment
Range on Protein: 495-732
Range on HMM: 52-290/305.0
EEINFTKNRYKNILPYDSARVKLeviDNNPHSDYFNASYIPS-FDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGD
 .|. |||||...   | . |||   |. . |||  | |.   .  .| .|..||| . . |.|| || |..|  | |. |  |  |.|| .|||   |.
adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

SVKF-GNIKVELVSLEAC-TGGIKRKMTMI----KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSV
 ... . | || ||         . ..|..     ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyi

VAH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
. . |.  .   . ..|  .|..| . .|.. || ||.  .|. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 491-728 2.2e-39 129.9 In-house 49-280 (290) alignment
Range on Protein: 491-728
Range on HMM: 49-280/290.0
TVAQEEINFTKNRYKNILPYDSARVKLEvidNNPHSDYFNASYIPSFdnDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKI
 . ... .|.|||||..   | .|| |.   .  . ||  | |.     .  .| .||. .... |.|||| ||.|..| |. .| |  | || .|.|. 
kifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

PGDSVKFGNIKVELVSLEACTGGIKRKMTMIK-GDD--YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSV
 |. . ||.| |     .     |..|.  ..  |.     .  ..   |||| |.. | .||. .. ..   |    |...|||||.||||  ..|.  
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievg

VAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.      . .|. . |  .|. |   || . ||  .  ..|
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveill

0043147 (Phosphotyrosine protein) phosphatases II 523-724 6.1e-39 128.8 In-house 2-154 (172) alignment
Range on Protein: 523-724
Range on HMM: 2-154/172.0
NPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLkegdkikcgkywpkipgdsvkfgnikvelvsleactggikrkmTMIK
...||| ||||..     . .|| ||| .  ..|||||......|.| ..|.|                                           . ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

GDDYRTVTQFHFTEWPDKGVPkHTSSLLKFIKEVKA-DHGQFTHPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPYMVQTQEQYA
 . .|.. |.... ||| ||| ... ||.|.. ..   . .  .| ..||||||||||... .. .       . ..... |  .|.|||..||...|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIY
|.|
fly

subfamily_PTPN1_pd Subfamily PTPN1 780-1015 6.1e-39 128.5 In-house 23-269 (290) alignment
Range on Protein: 780-1015
Range on HMM: 23-269/290.0
HTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINAS--QMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDA--
.||. ..  |...||| .  | .  |..|.. | ||||||  ... ..  .. || ||| ||. || .| . |  .|||||   . .   ||||||    
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-NSVQFG--SYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSdPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTA
 .....   ...|  .|. .    |.|.|...  ... ....... .  ||  |  |.  |  |  | .  .| . . .    ..|| .| ||.| || .
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgv.pespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

MECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  |...| . |    ||| ...  ||  |. ..|| .   | |  | |
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 497-729 6.7e-39 128.4 In-house 47-285 (305) alignment
Range on Protein: 497-729
Range on HMM: 47-285/305.0
INFTKNRYKNILPYDSARVKLEviDNNPHsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVK
 .  |||||..   |  |||||     || .|  | |. .  | | .| .| | . .  ||| | .|..| .| |. .|.|    || .|..   .| ..
qeagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FGN----IKVELVS-----LE-ACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISI
| .    | | . |     ..  .   ... . .|.  | . | ||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |. .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvml

DSVVAHAKTTRMVDV-FNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. ..    . ....     .  ||..|   .||..|| |..  .|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_PTPRN_pd Subfamily PTPRN 758-1015 1.8e-38 126.9 In-house 27-290 (297) alignment
Range on Protein: 758-1015
Range on HMM: 27-290/297.0
GRSKMTKEFQTLKSLCPDPPASHtrSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSLVLNYK
 .... ||...|..   .| ...   ... .|  |||. . || . .|| |..     ..||||||..      . ....|| ||..||.||| .| .  
nkdrlekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

PSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSD-GDMTIRQ--LKVTRNSKTsHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTN
   .|.|   ...  | |..||||  |  .. | |  .|      |  .|   ||  ..|.|  ||||. |  ||..|  ..  |.||... | |  |  
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPas..aksllefrrkvnksyr

KmNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
     .|.||| .|||||||..     ..... |   .||  |.. || .| ..|.|.... |.. .. |
G.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 760-1020 6.5e-38 125.1 In-house 10-280 (287) alignment
Range on Protein: 760-1020
Range on HMM: 10-280/287.0
SKMTKEFQTLKSLCPDPPASHtRSGRTRDNHPKNRYGNNLPLQRNRVILD-SPDH--DYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTV
 .. ||...||      .|   ..     .  ||||.. ||.  .||.|   ...  |||||  . . .   .|...| |...|| ||| .||. . ..|
ddvdkevdalkedsesstatf.kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv

VML-NDKSQNDKSCAQYWPDAN-SVQFGSYSVSTLST-SSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQ-LG-ARSLMKLIRAVKSSTNKM
...  .  .  . | .|||. .  .. | |||  |.    . . ..| |..     . .. | |...  ||...  |  .| .|  ..  . .. . .  
itmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
.   ..||.  |.||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|. .  | .|.
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 788-1014 8.3e-38 124.9 In-house 2-236 (237) alignment
Range on Protein: 788-1014
Range on HMM: 2-236/237.0
DNHPKNRYGNNLPLQRNRVILDSP--DHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDK-SQNDKSCAQYWPDANS-VQFG
.|. ||||||    . .||.|  .  . |||||. .||.     .....| || ..  ||| .| . | | .|||     .|.. | .|||...    .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVSTLSTSSDGDMTIRQLKVTRNS--KTSHTVTQYQFHGWPKHGSdPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIA
 ..||        | |.| | ....   |    . ||||  ||..|  ||  |  |    . .. |    .    ..|| .| ||||.|      . |  
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgv.pqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
|   |||.. |. .  ||   .||...| |....| 
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 496-655 9.9e-38 124.7 In-house 31-192 (297) alignment
Range on Protein: 496-655
Range on HMM: 31-192/297.0
EINFTKNRYKNILPYDSARVKLEviDNNPHSDYFNASYI--PSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGD
.  . ||||..|| .|..||||      . .|| || |.  |  ..|  || .||| .|. ||||..|....| .|.||.||.|. . ||  |||.. ..
nsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

SVKFGNIKVELVSLEAC--TGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKE
  | |.. || .|  .      |  ....|  .. | |.   |  |||.|||     | .|  .
rlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq

0049772 (Phosphotyrosine protein) phosphatases II 490-733 2.8e-37 124.5 In-house 38-282 (314) alignment
Range on Protein: 490-733
Range on HMM: 38-282/314.0
QTVAQEEINFTKNRYKNILPYDsARVKLEVIDNNPhSDYFNASYIPSFdndKAYIASQGPNNASTDDF----------WRMV--WQENVTTIAM------
 .||. . | .||||..|||.|  ||.|   ...  |||.||||. .|   ...||.|||..   .||          ||||  .. || .| |      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------VTKLKEGDkikcgkywpKIPgDSV-----KfgnikvelvsleactggikrK-------MtmikgddYRTVTQFHFTEWPDKGVP-
                ..| ..           .| .       |                    .                |.. ... . .|| ..| 
adelsrLdaAlgKtpllildgng.........nep.taadlellk....................eelydpelf.......erlgikylripvpDgsapl

-KHTSSLLKFIKEVkadhgQFTHPLIIHCSAGVGRTG--VVISIdsVVAHAkttRMvDVFNFVTNIRQKRP-----YMVQTQEQYAFIYGAVLEDLLW
 ..  ..|.||.|.     .  .|...||.||.||||  ||. .  .. .    .. ..   .  .|.|||      .....||| ||. |.|| | .
ledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf

0051429 (Phosphotyrosine protein) phosphatases II 813-1019 4.5e-37 123.5 In-house 4-227 (272) alignment
Range on Protein: 813-1019
Range on HMM: 4-227/272.0
HDYINASQMKGIhCT------FMTTQMPLPTTVSDFWSLvLNYKPSTVVMLNDKSQND-KSCAQYWP------------DANSVQFGSYSVSTLSTSSDG
 .||||. ..|  .       .  ...||| |. ||| |  ... .|.|.| . .  .   | .|||            .| .. .| ..| .||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAvksstnkmnEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVD-------
|...| | .|.    .....|.......|| ||  ..   ..|..|...         .  .|||| .| .|||... .  ..... . . ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ....|. ||| |...||||| |.|.|....|.| .
yleeaveelraqrpgavqteeqylflyeallellrs

0049260 (Phosphotyrosine protein) phosphatases II 534-724 4.9e-37 122.3 In-house 2-143 (152) alignment
Range on Protein: 534-724
Range on HMM: 2-143/152.0
IPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWpkipgdsvkfgnikvelvsleactggikrkmtmikgddyrtvtQFH
|. . . ...|| ||| . ...|||||... ..||| |.|.| | .|.|| .|.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.. ||| |||...  || ... ..    .  .| ..||||||||||... .. .       . |.....|  .|.|||..|....|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

0041856 (Phosphotyrosine protein) phosphatases II 789-1022 5.2e-37 122.6 In-house 1-176 (182) alignment
Range on Protein: 789-1022
Range on HMM: 1-176/182.0
NHPKNRYGNNLPLQRNRvildspDHDYINASQMKGIHCT--FMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNdksqndksCAQYWPdansvqfgsysvst
|..|||| . ||  ..|      | |||||. . | . .  |  || ||. || ||. .. ... .|.|.|.        . .|||              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..............

lstssdgdmtirqlkvtrnSKTSHTVTQYQFHGWPKHGSDPqlgARSLMKLIRAVKSstnkmNEFSILVHCLSGAGRTGVFCTAMECIAQiaegdSVDIF
                   ..  ....||....|| ||  .    ..| ..|..|..     ..  .||||  | ||||... |  .. .     .|...
...................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

QTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
..|| .|  |.. |.|.. | |......|.|.  ..
eavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 485-734 1.8e-36 120.6 In-house 29-274 (288) alignment
Range on Protein: 485-734
Range on HMM: 29-274/288.0
PNIYPQTVAQEEI-NFTKNRYKNILPYDSARVKLEvidNNPHSdYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKC
||  .. .... | | |..||.|.   | .||||.   ..|.  | .|  ..|  ...  | .| | |.  . .|.|. ...|  | |...| |  | | 
pneasidiidsfianptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks

GKYWPKIPGDSVKFGNIkVELVSLEActGGIKR--KMTMIK----GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVkadhGQFTHPLIIHCSAGVGR
 .|.|   |.....| .    |  .    .|..  |.....    |..   | . |. ||.|.|||.   | |.... .     ....|...|.||||||
aeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGr

TGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWR
|| .| |  ..  .. .  . . ..... |..|   .||. || ...  |||.|| .
tgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk

0046846 (Phosphotyrosine protein) phosphatases II 519-727 2.6e-36 120.4 In-house 5-169 (176) alignment
Range on Protein: 519-727
Range on HMM: 5-169/176.0
VIDNNPHSDYFNASYIPSFdndkAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVkfgnikvelvsleactggikrkm
..  ....|| ||..| .     ..|| ||| . .. ||..|......|.. ..|...| ...||  ||| . . ..                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tmikgddyrtvtQFHFTEWPDKGVPKHtSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDsvvaHAKTTRMVDVFNFVTNIRQKRP-YMVQTQ
            |.... ||| ||| . . ||.......    .  .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..|||.
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYAFIYGAV
||| |.| ..
eQyrflyefe

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 498-726 3.2e-36 119.7 In-house 33-254 (267) alignment
Range on Protein: 498-726
Range on HMM: 33-254/267.0
NFTKNRYKNILPYDSARVKLEVIDNNphsdYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEgDKIKcgKYWPKIPGDSVKF
|  .||. . |||| .|| |   ...    | ||||. ..   .|.|. |.| . .  ||. .. ...|..| ..||  . |.|.  ..||   |.. |.
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dnir..lfwPPkmgqakky

GNIKVELvSLEACTG--GIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSS-LLKFIkeVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT
 .. ||  |||       |      .| .  . || ... .|  .   |     |.  .   | .  .  .||...||.||||.|  . ||| .  ||| 
qdltveh.slekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
 ..|.|.|. .||..|. .|.|.|.| .|.  
gvsdifdflrkirsqriglvdtkeryiyihel

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 761-1022 2.8e-35 116.4 In-house 28-288 (290) alignment
Range on Protein: 761-1022
Range on HMM: 28-288/290.0
KMTKEFqtLKSLCPD-PPASHTRSGRTRDN-HPKNRYGNNLPLQRNRVIL-DSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVML
...||.  |. | |  |     |.   ..    |||| .    .. |||| |  | ||. |  .||.. .|. || .|  || |.| .||. | ...|||
elakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivml

NDKSQNDKS-CAQYWPDAN--SVQFGSYSV-STLSTSSDGDMTIRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdpqlgARSLMKLIRAVKSsTNKMNEfS
 .  .. |. |.||.|. .   . ||...|  ..... | ..  . | |  ..|  .| .  ..   || .       | | . |.| ...   |..   
celiedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtlri.lrkasG.p

ILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
. ||| .| |||| | .   ..  . .| ..|. ..|. ||  |.. || . .|  . ... ..    .|
vvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky

subfamily_ptpA1_pd Subfamily ptpA1 495-683 3.9e-35 116.4 In-house 44-248 (418) alignment
Range on Protein: 495-683
Range on HMM: 44-248/418.0
EEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSfDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPK-IPGD
.. | .|||| |||| . .||.|. |...  ||| || ||      | .|..|||   .  |||||||.. .  | |...  |  .||| .|||. | |.
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

SV--------KFGNIKVELVSL--EACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF------THPLIIHCSAGVGR
 .         ||   |||| .  .     | |.. .    . | .||...  |||. .| ||  . .... .   . |         |.|.||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGVVIS
|| . .
tgtfct

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 620-767 4.8e-35 115.7 In-house 82-230 (440) alignment
Range on Protein: 620-767
Range on HMM: 82-230/440.0
MIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQE
.|.| . ||. |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||.|..||.. .|| .  .|.|.|. ..|..|| |||| |
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
||||.. |||| ||  .|||     |.......       .| . .||.
qyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe

0051082 (Phosphotyrosine protein) phosphatases II 524-727 4.9e-34 112.4 In-house 1-149 (151) alignment
Range on Protein: 524-727
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdndkaYIASQGPnnasTDDFWRMVWQENVTTIAMVTKLKEGDkiKCGKYWPKIPgdsvkfgnikvelvsleactggikrkmtmikg
|.|||.|.||. ..     ...|.||    ..||..........|| ......| .  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ddyRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdhgQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrmVDVFNFVTNIRQKRPYMVQTQEQYAFI
   ..|...... ||| |.| .. ..|.|.... .   .  .|...|||||.||||... .. .  .      |...  .  .|.|||..||. .|. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YGAV
. |.
lfal

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 760-1017 5.2e-34 112.4 In-house 20-279 (439) alignment
Range on Protein: 760-1017
Range on HMM: 20-279/439.0
SKMTKEFQTLKSLCPDPPASHTRSGRTRDnHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPST
  ....|....|  ||  .  .   .  | ..|||| .  ...  ||.|      |   ||||  .|| .    ...||.|   |. ||| ||.. | .|
eifkeifekinstspdyaciaslaaqeyd.qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

VVMLNDKSQNDKscaqYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS---KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNE
.||| .  .  |    |||  . | .|  .| .       . .|| .||  .    .  .|| |...  ||..    |  |  .....||..|. .| . 
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeey

FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  ..||| .| ||||   .   .. |.   . |||   ||.|| .| |.||.  .| |.|. . | .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 492-731 1.6e-33 110.9 In-house 29-270 (285) alignment
Range on Protein: 492-731
Range on HMM: 29-270/285.0
VAQEEINFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYIPSFDND-KAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKI
 .  | |   ||| ..   . .|| |.    |   ||  ||..    .|  .||..|||   .  |||.|..||... . |.  | ||   ||  |.|. 
ytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

PGDSVKFGNIKVELVS--LEACTGGIKRKMTMIKGDDYRTV----TQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQfTHPLIIHCSAGVGRTGVVISI
 |. ||||. .. |     || .| |   .|.|. .|  .      . .   |||.  |. .  .... | ||    .  .|. .|||||||||  .. |
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgi

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
|    .      ..... | ..|  |   ||.. |. |.|  ..| .
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

PTPc_DSPc_SM00012 628-729 2.3e-33 109.9 In-house 1-105 (105) alignment
Range on Protein: 628-729
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
||...|.|.|||.|||....|.|.....||  . .   ..|...||||||||||... .| .. . ... . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle

0044763 (Phosphotyrosine protein) phosphatases II 509-726 5.6e-33 109.4 In-house 1-166 (178) alignment
Range on Protein: 509-726
Range on HMM: 1-166/178.0
PYDSARVKLEVIDNNPHSDYFNASYIPSFdndkAYIASQGPnnastDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGdsvkfgnikvelvsle
|.|  ||.|. . . . |||.|||.|  .     |..|..|      |..........|.| ..|. .|. ..|| .|||.  |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

actggikrkmtmikgddyrtvTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttRMvDVFNFVTNIRQ
                      |.... .|| |||  .. .|.|.. ... . .  .| ..||||||||.|... .. .  .    .. .... .  .|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

KRPyMVQTQEQYAFIYGA
.|| .|....|. ..|  
rRp.ivpnpgqlrqLyef

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 760-1017 1.3e-32 107.9 In-house 6-259 (267) alignment
Range on Protein: 760-1017
Range on HMM: 6-259/267.0
SKMTKEFQTLKSLCPDppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVML
 .. |||. .| . ..   |      . .|. .||. .||| . .||||   ...||||| ..| .   .|. || ||  |..||. .. ..| ...|.|
ceiekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDkSQNDKsCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDpQLGARSLMKLIrAvKSSTnKMNEFSILV
   .  |.   ..||    .. ..   .|       . |  |  |..  . ...| || | .. |     . .   . |. .. | |    .  .  ..|
tk.vftdn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnn.kpylkplfgil.a.knql.engnrPlvv

HCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|  | ||.| | ..   . .. . . .|||. .. .|  |. .|.| |.| ...... || 
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 774-876 2e-32 107.1 In-house 30-147 (392) alignment
Range on Protein: 774-876
Range on HMM: 30-147/392.0
PDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-----KSQ
|.|.......... .| .||||.|.||....||.|    |.||.||.|||.......  .....|.| .....|||..|.. ...|..|...     | .
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

NDKSCAQY----WPDANS
.....||.    |||.. 
dartvaqfhftewPdkdv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 500-726 4.8e-32 105.9 In-house 52-277 (301) alignment
Range on Protein: 500-726
Range on HMM: 52-277/301.0
TKNRYKNIlPYDSaRVKLEVIDNNPHSdYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGN
 |.||... | .     .|||..        | .||.  . . .||.||| .....||| |. | .| .|.|...  |  . || .| |  ...... | 
dkhryptv.PckP.stavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

IKVELVSLEACTGG--IKRKMTMIKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAHAKTT
 |..... |       .||.. .       . |||| . ..||.|.||||    | .... ||  .    .|...|||||.||.   |. . .  . .. 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylarevead

RMVDVFNFVTNIRQKRPYMVQTQEQYAFI-YGA
. ... . . ..|..|   |||..|  ..  |.
ptieltealkhlrehrwngvqtnsqlywmtlGt

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 785-1011 2.1e-31 103.9 In-house 4-235 (239) alignment
Range on Protein: 785-1011
Range on HMM: 4-235/239.0
RTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANS
. | |. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| .. . .   .|||    .   | | |||||. |
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

vQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLGArSLMKLIRAV-KSSTNKMNefSILVHCLSGAGRTGVFCTAMECI
 ..    |.   |    |  || . ...  .|    | ||.|  || .|  ||  . ... | | . | |         ..|| .| |||| |      .
.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgv.pqyat.avlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
 |  .  .||||. || .| || ..||| |.| |.. 
rqakkqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 785-1012 2.1e-31 103.9 In-house 3-235 (239) alignment
Range on Protein: 785-1012
Range on HMM: 3-235/239.0
RTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANS
. | |. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| .. . .   .|||    .   | | |||||. |
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

vQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLGArSLMKLIRAV-KSSTNKMNefSILVHCLSGAGRTGVFCTAMECI
 ..    |.   |    |  || . ...  .|    | ||.|  || .|  ||  . ... | | . | |         ..|| .| |||| |      .
.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgv.pqyat.avlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 |  .  .||||. || .| || ..||| |.| |..  
rqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 498-724 9.5e-31 101.5 In-house 52-283 (310) alignment
Range on Protein: 498-724
Range on HMM: 52-283/310.0
NFTKNRYKNILPYDSARVKLEvIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGDSVKF
.. |||| ...  |..||||. ||.  . ||  | |. .    ...| |||| . .  |||||..||   .| .. |  |  . ||  ||| . | .  .
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtety

GNIKVELVS-----LEACTGGIKRKMTMIKGDDYR------TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDS
| |.|  .|     .| |   .      .  |.         |.  .. .|||.|||      .      .  ||    | ..|||||..|..||.... 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalkl

VVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 . ...    ||. . .|.....|   .||. || .| 
kidkldrglkvdaeevktellksraiciqtelqyliid

subfamily_egg_pd Subfamily egg 490-728 4.1e-30 99.5 In-house 32-267 (307) alignment
Range on Protein: 490-728
Range on HMM: 32-267/307.0
QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDkiKCGKYWPK
 | | .. | .| | | .   ||.|||||.       |.  | ..        .| .| |   . |||||||.||.|  | |.|  || .  .|  ||||
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpk

IPGDSVKF--GNIKVELVSLEACTGGIKR--KMTMIKGDdyrtVTQFHFTEWpdKGVPKHTSSLLKFIkEVKADHGQFTHPLIIHCSAGVGRTGVVISID
 . ||...  |....| . ..  .  . |  |. .. ||      . .   |  .|  ...| .   . .|     . ..| ....  || .......|.
aesdslvtvpGslrienlkvdskadplfrvtklklvGgd....deerflehw..qgdvnnssdvyspl.rvlrklrnlskpvvvqdilGvskaatlvaie

SVVAHAK--TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  . .     .    | . |  .|..|.. |..  .| |.|  ||
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_ptpA1_pd Subfamily ptpA1 761-973 4.4e-30 99.7 In-house 22-252 (418) alignment
Range on Protein: 761-973
Range on HMM: 22-252/418.0
KMTKEFQTLKSLC-PdppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC-TFMTTQMPLPTTVSDFWSLVLNYKPSTV
|. .||. |.    |    | |  |  . |  |||| | ||... || |    |    |||||  . | .   |. || ||| |..||| .| . .   .
kikeefrlleesvgp....setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcrii

VMLNDKSQNDK-SCAQYWPDAN-----------SVQFGSYSVSTLSTSSDGD--MTIRQLKVTRNSKTsHTVTQYQFHGWPKHGS-DPQLGARSLMKLIR
|||. .|.| .  | .|||.                ||.|||  .    | .  .  |....| . .| . .||||. ||| |   |     | |.. | 
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsit

AVKSS--TNKMNEFSILVHCLSGAGRTGVFCTAMEC
  .     .   .  |.||| .| |||| ||||.  
nrqnqiipssdrnvpiivhcsagvgrtgtfctavim

0046846 (Phosphotyrosine protein) phosphatases II 804-1017 5.1e-29 96.7 In-house 3-173 (176) alignment
Range on Protein: 804-1017
Range on HMM: 3-173/176.0
NRVILDSPDHDYINASQMKGihCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKS-QNDKSCAQYWPDANSVQFgsysvstlstssdgdmtirqlkv
 |.. . .| |||||. . |  . . .|| ||| |. ||. ...... ..||.|..    .  .|..|||.  ....                       
lrllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

trnsktshtvtQYQFHGWPKHGSDPQlgaRSLMKLIRAVKSSTNKMneFSILVHCLSGAGRTGVFCTAMeciaQIAEGDSVDIFQTVKILRADRM-QFVQ
           ||....|| ||  .    . |..|......  ..     .||||  | ||||... |      .  .  ........ .|. |. . ||
...........qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TEEEYAFVYDVIREYL
|.| | |.|......|
tpeQyrflyefellll

0049772 (Phosphotyrosine protein) phosphatases II 782-1018 5.3e-29 97.3 In-house 39-281 (314) alignment
Range on Protein: 782-1018
Range on HMM: 39-281/314.0
RSGRTRDNHPKNRYGNNLPLQrNRVILDS---PDHDYINASQMKGIhCTFMTTQMPLPTTVSDF----------WSLVL--NYKPSTVVM----------
  ..   |. |||| . ||   |||||..    ..|||||| ..|. ..|. || ||. || ||          |..||   ... ..||          
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LNDKSQNDkscaQYWPDANSVQFGsysvstlstssdgdmtirqlkvTRN---SKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVk
           |.. . |      ... |.  ..                       ..    .. .... .|  . .| .. ..    ......|... 
srLdaAlgKtpllildgng....neptaadlellk......................eelydpelferlgikylripvpDgsaplledfdeflefieea.

sstnkMNEFSILVHCLSGAGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRM-----QFVQTEEEYAFVYDVIREYLH
      ..  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... |.| |......||| 
.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

0036282 (Phosphotyrosine protein) phosphatases II 813-1011 5.3e-29 96.5 In-house 2-164 (174) alignment
Range on Protein: 813-1011
Range on HMM: 2-164/174.0
HDYINASQMKGIHCT--FMTTQMPLPttvsdFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDansvqfgsysvstlstssdgdmtirqlkvtRNSKTS
.|||||| ... ..|  .  .| ||.     || .. ... .|||||..  ...   | .|||.                              . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HTVTQYQFHGWPKHGSDPQLGarsLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAeGDSVDIFQTVKILRADRMQFVQTEEEYAFV
... ||.. .|| ||  .      | .....|..  .. ..  .||||  | ||||... |. .. ..   . ||....|. ||  |.. |||.. | |.
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YD
|.
yy

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 789-1020 1.1e-28 95.0 In-house 35-273 (285) alignment
Range on Protein: 789-1020
Range on HMM: 35-273/285.0
NHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK--G-IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDA--NSVQFGSY
|   ||| .   ..  ||.|   |.||| || |.  |  . |..||| ||| |.|||| .. . | . |.||    .   . || |.|.   . |.|| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVSTLSTSSDG-DMTI-RQLKVTRNSKTS-H--TVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKmnEFSILVHCLSGAGRTGVFCTAMECIAQI
 ..      .    ||   | |.    .|     . . |   || . . |.  || ...| . ||    |  |  | ||| .| |||  |     .  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla.pe.darpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatiri

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 |   ..... |. .|| |.| ||.  .. |.| |. ||.  |
menpniemldivremramrfqavqshmqflflyvvlmeyfige

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 501-738 9.6e-28 92.1 In-house 22-257 (290) alignment
Range on Protein: 501-738
Range on HMM: 22-257/290.0
KNRYKNILpYDSARVKLEVIDNNPHSDYFNASYIpSFDNDKAYIASQGPNNAS-------TDDFWRMVWQENVTTIAMVTKLKEGDKI----KCGKYWPK
..|... |    .|| |..  .   .||. |... .. |. . |..| | ..          .|| |. ||.|. . |. . .| ..      | || |.
dqRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

IPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDD-YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVV
  |...||....|.  | |.  . ..|....  .|.   |||   . .| .  |...| .||. |. |||     . | |.||  |. |  .. .|.   
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgy

AH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLedllwrntlI
   |.|.  | . . . ..|..|  ........||.  ...         .
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........l

PTPc_DSPc_SM00012 911-1014 1.4e-27 91.3 In-house 1-104 (105) alignment
Range on Protein: 911-1014
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNKMN-EFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||   .    |...|.||||...|| . . ...|||  |.||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

VYDVIR
.|... 
lyrall

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 757-1025 4.6e-27 89.8 In-house 13-288 (307) alignment
Range on Protein: 757-1025
Range on HMM: 13-288/307.0
RGRSKMTKEFQTLKSLCPDPPASHTrsgrTRDNHPKNRYGNNLPLQRNRVILDSP--DHDYINASQMkGIH---CTFMTTQMPLPTTVSDFWSLVLNYKP
.| .... ||. |    |.  . ..     . |  |||| .    ...|...  .    ||| |  . ||      |. .| || .|. .||..... | 
kgvqalvdefrvlakktpegvtvea....fsantdknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekv

STVVMLNDKSQNDK-SCAQYWPDAN--SVQFGSY----SVSTLST---SSDGD-MTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRA
 .|.|| .  .  |  | ||||  .     ||.     ||. | .   . | | . . .|||    . | |....|.. || .|  ||.   . . |. |
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgv.pqinl.tainllea

VKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY---LHTENYEQL
|.  ||      ..||| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| ... |. ||   |. | ||.|
vrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel

0043147 (Phosphotyrosine protein) phosphatases II 811-1011 1.7e-26 88.4 In-house 3-155 (172) alignment
Range on Protein: 811-1011
Range on HMM: 3-155/172.0
PDHDYINASQMKGIHCT--FMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKsqndkscaqywpdansvqfgsysvstlstssdgdmtirqlkVTRNSKT
...|||||| ... ...  |  || ||. |..||| .. ... ...|.|..                                          ..  .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

SHTVTQYQFHGWPKHGSDpqlGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAF
.... ||....|| ||      .. |..... ...  .. ..  .||||  | ||||... |  ..       .......|. .|. |.. ||... | |
erlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

VYD
.|.
lyy

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 501-732 6.8e-26 85.7 In-house 46-277 (312) alignment
Range on Protein: 501-732
Range on HMM: 46-277/312.0
KNRYKNILPYDSARVKLEViDNNphsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWpkipGDSVKFGNI
 ||| ||  .|  |  |   |.|    |  | ..    . . ....||| . ..  ||...     |.| ... . |    || ||      | | | ..
lnrypniqcwdrgrftlag.den...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi....sdivgfvdl

KVELVSLEACT-----GGIKRKMTM------IKG-DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVV
.   |  | ||     |  | |.|       .|   .   . .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.|..
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmi

AHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
|  .  |  .| .    .|. |   |..  || .   .||| | 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly

0051082 (Phosphotyrosine protein) phosphatases II 812-1013 1.2e-25 85.2 In-house 2-149 (151) alignment
Range on Protein: 812-1013
Range on HMM: 2-149/151.0
DHDYINASQMKGIhctFMTTQMPLPttvsDFWSLVLNYKPSTVVMLNDKSQNDkSCAQYWPDANsvqfgsysvstlstssdgdmtirqlkvtrnsktsHT
  ||||.|.. |    .  ...||.    ||. |. ... .|.|.|...  ..  |..|.|...                                  ..
lsdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................ie

VTQYQFHGWPKHGsdPQLGARSLMKLIRAVKSstnkMNEFSILVHCLSGAGRTGVFCTAMECIAQiaegdsVDIFQTVKILRADRMQFVQTEEEYAFVYD
|.......|| .|   .|   ......... .    ...  .|||| .| ||||... .. .. .      |....... .|. |. .||..... |.. 
vlhipildwpdpg..lplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

VI
..
al

subfamily_CG42327_pd Subfamily CG42327 476-658 2.7e-25 83.7 In-house 8-192 (319) alignment
Range on Protein: 476-658
Range on HMM: 8-192/319.0
SEEFHDLPgpNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDND-KAYIASQGPNNASTDDFWRMVWQENVTTIAMVTK
 |||.|||  ..  .. .       |.|. |..|   .|| |. | ..... |..|||.  .|.    |||.| . . |. ||||.||. .  .|  .|.
aeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LKEGDKIKCGKYWPKIPG-D-SVKFGNIKVELVSLEACTGGIKRKM--TMIKGDDYRTVTQFHFtEWPDKGVPKHTSSLLKFIKEVKA
| |    .| .|.|   . |    .|.|.| |   |.    .   .    ....  | .| . . .|.. .|| . ..|.  . ||..
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 761-1022 1e-24 81.8 In-house 25-293 (305) alignment
Range on Protein: 761-1022
Range on HMM: 25-293/305.0
KMTKEFQTL-KSLCPDPPASHTRSGRTRD-NHPKNRYGNNLPLQRNRVILDSPD-HDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSLVLNYKPSTV
|. .||. | |   ||       . .. | .  |||| .    ... | || |   ||| |  .      .  |. .| ||  |. .|| .|.. |   .
klreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqi

VMLNDKSQNDK-SCAQYWPDANSVQF---GSYSVSTLST----SSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQlGARSlMKLIRAVKSStn
|||    .  |  |||||| |.  .    .   |  .|       | .. |  |..| . . . .| . |.  ||  |  |     | ..|. |.. |  
vmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc.klts.lellsairgs..

kmnEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHtENY
   .  |.||| .| ||||   .    . .|||  ..  . . || || .|   .|.. .| |.. |. .|.  |.|
...kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 822-1015 2.2e-24 80.7 In-house 86-284 (301) alignment
Range on Protein: 822-1015
Range on HMM: 86-284/301.0
KGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPD--ANSVQFGSYSVSTLSTSS--DGDMTIRQLKVTRNSK--TSHTVTQ
.|    |..|| ||. |  ||| ..  |.  ..|||  | . . . |..| |   ..... | ... . .. .  . ... |.|.|.  ..  ...||| 
sGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvth

YQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCtAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAF-----
||.. |...|  |.  |  |..|.  || | .      |.||| .| ||.  |  . |..|.  | |  ... ...| || .| . |||..   .     
yqysewtdrgv.Pksha.elfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsqlywmtlGt

VYDVIRE
|| .|.|
vyrlike

0049260 (Phosphotyrosine protein) phosphatases II 826-1011 3.2e-24 80.8 In-house 9-144 (152) alignment
Range on Protein: 826-1011
Range on HMM: 9-144/152.0
CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWpdansvqfgsysvstlstssdgdmtirqlkvtrnsktshtvtQYQFHGWPKHG
  |. || |.| |..||| .. ... .|.|||.. . ..|  |.||.                                          ||... || ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhg

SDPQLGARSLMKLIRAVKsstNKMNEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
  .       . |.       .. ..  .||||  | ||||... |  ..        |.....|. .|. |.. |.... . |.|.
vpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 498-728 9.3e-23 75.1 In-house 51-282 (302) alignment
Range on Protein: 498-728
Range on HMM: 51-282/302.0
NFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYI--PSFDndKAYIASQGPNNAST---DDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPKIPG
|  ||. ...  .|| .||||    .   .| ||| .  |..   .  | .| |.  |.   ..|||||.||..... .. . .| .|    ...||  |
nlkknqsedvpildsnlvkle....aepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRT---VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVA
| ...|.. |     |   .  .| .  .  ...     ..  ..| |..| ||.. ..| | ...| | . . .....|    |.|| |....   .| 
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
. ..   . . . |..||..|| .|.. .||...| |.|
klqkgkepnikeivksiRsqRpravdslkQyvslyiall

0048076 (Phosphotyrosine protein) phosphatases II 586-727 1.1e-22 75.6 In-house 2-139 (145) alignment
Range on Protein: 586-727
Range on HMM: 2-139/145.0
YWPKIPGDSVKFGNIKVELVSLEACTGGIKR--KMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVIS
|||    ... .|.. . |   . .  ||..   .|. . . .|...|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||... 
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDSVVAhakttRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAV
.. .       . |.... .  .|..||..|....|. |.| ..
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 783-1019 1.2e-22 75.0 In-house 42-289 (305) alignment
Range on Protein: 783-1019
Range on HMM: 42-289/305.0
SGRTRDNHPKNRYGNNLPLQRNRVILDSP-DHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVML-NDKSQNDKSCAQYWPDA--NS
. .  ... |||| .   |..||| |..|  |.|| |  .        |. || ||  | .||| . |. |  .. || | . .  | |..|..    . 
afkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

-----------VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTG
           |.| | .   . .... ..|  .| .    .... ||.| .  ||  |  .     ....|.   ..|        | ||| .| ||||
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarpskg.....pivvhcsagigrtg

VFCTAMECIAQIAEGDSVDIFQ-TVKILRADRMQFVQTEEEYAFVYDVIREYLHT
        . |. .|. ..  .  .. .| .| . .||...| ||..|| .|.. 
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 813-1014 2.5e-22 74.4 In-house 46-256 (290) alignment
Range on Protein: 813-1014
Range on HMM: 46-256/290.0
HDYINASQMKGI-HCTFMTTQMPLPT-------TVSDFWSLVLNYKPSTVVMLNDKSQNDK-----SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTI
 ||| |....      .. || |.         |. .|| .. . |   |||| . .....     .||.| |..    ..|.  .|.  |   . |. .
ddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADR
|.| |. . .  .||| ....|| |    ..   ..|..||. || |.       ..|||  |  |  .. .       ||   .|| . . .| ||  |
RelvvkfddeeeftvtHsllkgWnklnvqed..tktllsliqkvkaskt.....pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

MQFVQTEEEYAFVYDVIR
 . .....|.|||  .| 
alaitsalelafvdagiv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 548-730 2.7e-22 73.6 In-house 98-287 (302) alignment
Range on Protein: 548-730
Range on HMM: 98-287/302.0
GPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGG----IKRKMTMI-------KGDDYRTVTQFHFTE
 | . ... .| .. | ||. .. .....|... || .|. .  |. .|||.  |. ||..          . |.  .       | .  .||  ..|. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKGVPKHTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
|||.| ||.. . |. .|  ..    . . ...|||||||||| ...|   .   .. .. |. . |. .|| |   ||...|  ..   |   
wpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 498-611 7.3e-22 72.5 In-house 47-169 (350) alignment
Range on Protein: 498-611
Range on HMM: 47-169/350.0
NFTKNRYKNILPYDSARVKLE----VID----NNPHSDYFNASYIP------SFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKC
 |.||||||||||. .||||.      |        .|| ||.|.       . . |  ||| |.|     |||.... . .|. | ..|.. | .  ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

GKYWPKIpgdsvKFGNIKVELVSLEACT
 .||..      .. .|.| | |    .
yrYWqeg.....sydditvklaskweni

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 789-1024 1.7e-21 71.6 In-house 43-278 (288) alignment
Range on Protein: 789-1024
Range on HMM: 43-278/288.0
NHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYS
|  ..|| |       || |.   . ||.|  .   .    .. .| || .|.  .| ..|.     .|||..  .  |   |.|.|    .....| . 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VSTLSTSSDGDMTIR--QLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGD
  .    .| | ...   |..... ...  | .  .. |...|   .    | ..|.  .|| ..      |.||.  |.|||| .   .  . ..   |
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPeny..lsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrldd

SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
 . | . .. ||..|.. .|||  | .|. .. |.|    |..
flgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 827-1012 3.3e-21 70.4 In-house 5-198 (198) alignment
Range on Protein: 827-1012
Range on HMM: 5-198/198.0
TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT---SHTVTQYQFHGW
 ...|| ||  |..||| .| .     .||.||  .| .   . ||| ..|   ..|| ||.| . ..  |.||  | .| |. .   .  ...|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHgSDPQLG-ARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .. . |..     ..   | |    .. ..  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
kek.ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 827-1012 3.5e-21 70.3 In-house 6-199 (199) alignment
Range on Protein: 827-1012
Range on HMM: 6-199/199.0
TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT---SHTVTQYQFHGW
 ...|| ||  |..||| .| .     .||.||  .| .   . ||| ..|   ..|| ||.| . ..  |.||  | .| |. .   .  ...|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHgSDPQLG-ARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .. . |..     ..   | |    .. ..  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
kek.ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 540-724 5.2e-21 69.7 In-house 4-197 (199) alignment
Range on Protein: 540-724
Range on HMM: 4-197/199.0
DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTG-----GIKRKMTmIKGDDYRTVTQFHF
.. |||.| |   .  |||.|||.     | ||   .   .     |||     . |.|.. |   .. .         |  . |       | .... |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.tappstreishyqf

TEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
| | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..| |||
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 540-724 5.3e-21 69.7 In-house 3-196 (198) alignment
Range on Protein: 540-724
Range on HMM: 3-196/198.0
DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTG-----GIKRKMTmIKGDDYRTVTQFHF
.. |||.| |   .  |||.|||.     | ||   .   .     |||     . |.|.. |   .. .         |  . |       | .... |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.tappstreishyqf

TEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
| | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..| |||
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

0048179 (Phosphotyrosine protein) phosphatases II 613-724 5.4e-21 70.3 In-house 29-138 (144) alignment
Range on Protein: 613-724
Range on HMM: 29-138/144.0
GIKRKMTMIKG----DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDSVVahakTTRmVDVFNFVTNIRQ
||.   ... .    .  |...|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||... .. ..    . . ..... .  .|.
gittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrs

KRPYMVQTQEQYAFIY
.||..|....|. |..
rrpgavpnpgqlrfLl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 907-1019 3.7e-20 66.7 In-house 86-196 (440) alignment
Range on Protein: 907-1019
Range on HMM: 86-196/440.0
KTSHTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEY
  |.|. ||...||| .|  |.. |  ..|.|. |. | .|  .  .|||| .|||||||  .    . .    | .|||  .. .| .| |.||| |.|
iesrtlkqyhyqgwpdkgv.pkf.agpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

AFVYDVIREYLHT
|||.... | | .
afvheavlegllc

0044763 (Phosphotyrosine protein) phosphatases II 802-1018 7.1e-20 66.8 In-house 3-172 (178) alignment
Range on Protein: 802-1018
Range on HMM: 3-172/178.0
QRNRVILDSPDH----DYINASQMKGIhcTFMTTQMPlpttvSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDANSvqfgsysvstlstssdgdmt
 |.||.|... .    ||||||.. .    ..... |     .|.. |. ... ...|.|..   .   .| .|||. ..                    
drtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag....................

irqlkvtrnsktshtvTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSSTNkmneFSILVHCLSGAGRTGVFCTAMECIAQiaegdSVDIFQTVKILRAD
                 ||.. ..| ||  .     . ....|... .. .      .||||  | ||.|... |  .. .     ...... .. .|. 
................iqylhipipDhgvpdllehflefvefieealdekg....gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RMqFVQTEEEYAFVYDVIREYLH
|. .|.... . ..|.. ...| 
Rp.ivpnpgqlrqLyefelrllk

subfamily_eak_pd Subfamily eak 493-737 1.1e-19 65.0 In-house 47-311 (332) alignment
Range on Protein: 493-737
Range on HMM: 47-311/332.0
AQEEINFTKNrYKNILPYDSARVKLEVIDNNPHsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPG
..   .  .|   .|.|||   |.|     |.   | ||| .   .  . || .  ...     ||.|| ...  .| .. .  | .  |  ||.|.   
tarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

DSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTS--SLLKFIKEVKA------------------DHGQFTHPLIIHCS
. .||| ..||  .         |.. . ||..   |  ...  | .  .||     .| | .||| .                   |   ..  || ..
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsa

AGVGRTGVVISIDSVVA--HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
 |  |.|| . || ..    .| . .  | ...  ...|| . | .. |..||| .||. || ||  
rGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 535-731 4.9e-19 63.4 In-house 27-221 (255) alignment
Range on Protein: 535-731
Range on HMM: 27-221/255.0
PSFDNDKAYIASQgpnnaSTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSleACTGGIK--RKMTMIKG--DDYRTVT
|. |...  . |      . | |.... | . ....|.. ..| .. || .|.|    .  |. ...|      . .  .   ...|   |     .||.
Pekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA------HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 .... |..|  |. .  .|. .| |.       .....|||.|.||.   . ...|        .   |  .|  ......|.||.  ..|  | ||  
hysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

GAVLEDL
  ||. .
lmvldlv

subfamily_egg_pd Subfamily egg 809-1015 1.1e-18 61.9 In-house 68-268 (307) alignment
Range on Protein: 809-1015
Range on HMM: 68-268/307.0
DspdhDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNdKSCAQYWPDAN--SVQF--GSYSVSTLSTSSDGD--MTIRQL
|    |.| | ..||  .  .|. .| ||  || ||| .| . .   .|||. . .. . |  ||| |.  |...  ||. . .|   |  |  ... .|
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

KVTRNSKTSHTVTQYQFHgWpKHGSDpqlgARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGDS--VDIFQTVKILRADRMQ
|.    .    .  .|   . .. ||      | ....| ..  ..      ..|..  |  ..... ..   . ..  |      . ..|. ||  |  
klvGgddeerflehwqgd.v.nnssd....vysplrvlrklrnlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

FVQTEEEYAFVYDVIRE
 |..   | ||| ..  
svesvllylfvyrlvlf

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 838-1017 1.8e-18 61.6 In-house 40-221 (255) alignment
Range on Protein: 838-1017
Range on HMM: 40-221/255.0
TVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN---SKTSHTVTQYQFHGWPKHGSdPQLgARS
||  |.  .   |...|||| |  . . . | .|.|     .     |.  .| |  |. .| |..| .    |  |||. |...||... . |.| || 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna.Pel.are

LMKLIRAVKSStnKmnefSILVHCLSGAGRTGVFCTAmECIAQ-----IAE--GDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.......|. |  |    |..||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|  . ||   .. ...
ilnilkvvrds..k....svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 787-926 2.1e-18 61.2 In-house 31-180 (297) alignment
Range on Protein: 787-926
Range on HMM: 31-180/297.0
RDNHPKNRYGNNLPLQRNRVILD--SPDHDYINASQMK----GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDAN--SV
     |||| . |  . .|| |    ...|||||  .          .. .| || .|| ||| || .    ..||.    ..  . || |||...    
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

QFGSYSVSTLSTSSDG--DMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSD
. |.. |  ||. ||    . . .|..    . |  |.  || .|| ||  
kagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvp

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 762-1021 3.2e-18 60.5 In-house 21-280 (312) alignment
Range on Protein: 762-1021
Range on HMM: 21-280/312.0
MTKEFQTLKSLCPDPPAshTRSGRTRDnhpKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND
.|||....  . .|     |   . .|    ||| |    .| |  |   .  || |  .|       |..|| ||  |.. || |.|.   .....|  
ltkeykavgnivsdsec..taflkfkd...lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

KSQ-NDKSCAQYWPDAN-SVQFGSYSVSTL-------STSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmn
  .   . ||.|  |    |..  . | |           |   .| | |||  ..      . .||.  || ||        . ..|. |||   .   
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds..cdtalrllsavkkdkk...

efSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
   .. || .| |||| ..     || .      .. ..  .|| || . |..  .| ..  .. |.|... 
..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 497-732 7.9e-18 59.1 In-house 46-280 (303) alignment
Range on Protein: 497-732
Range on HMM: 46-280/303.0
INFTKNRYKNILPYDSARVKLEvidnnpHSDYFNASYIpSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGDSVK
 |. |||. ...  | ..|||        | |  |||.  .| .|  | .| | . .. |||.|. ...|  . ..    | ||.     .|.   | .|
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflk

FGN--IKV-ELVSLEACTgGIKRKMTMIKGDDYRTVT-QFHFTEWPDKGVPKH-TSSLLKFIKEVKADHGQFT--HPLIIHCSAGVGRTGVVISIDSV--
| .  |.| |.  .|    | . |.  .   ||..     |. .|| . .| . .. ..| | ....   ...  .| .    .|.||.|    ...   
feersirvgefkrvelgd.gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

VAHAkTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
  |.     .|. . . |.|. | . ||   |....|  . | .|
slhs.eqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 767-1016 1.1e-17 58.7 In-house 15-268 (281) alignment
Range on Protein: 767-1016
Range on HMM: 15-268/281.0
QTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS--P---DHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND
| .  |  |||.          |  |||| |   |.  || |    |     ||| |  ..   ..  .. || |   | .||| .. . . ...||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

K-SQNDKSCAQYWPDAN--SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNkmnefSILVH
    | . ||.|.|      .||  .|||   .. .  .   .|... . .| . .|.. .. ||     |.  .  ..|..| ... .        ..|
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqv.pe.ssevmlkilrkirarst.....ppvih

CLSGAGRTGVFCTAMECIAQIAE-GDSVDIFQTVKILRA-DRMQFVQTEEEYAFVYDVIREY
| .| ||.| . .   ..  |       || | |  ||   |   ||| ..| ... |. ..
csagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 787-1018 1.4e-17 58.1 In-house 49-286 (302) alignment
Range on Protein: 787-1018
Range on HMM: 49-286/302.0
RDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC--TFMTTQMPLPTTV---SDFWSLVLNYKPSTVVMLNDKSQNDKSCAQYWP--DANSVQF
..|  ||.  .   |. |.|.|.    .|.|||...  ..  . . .|.|  ...    .|| .| . |  .||.|  . . .|.  ...|    . ...
kknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykey

GSYSVSTLSTSSDGDMTiR--QLKVT-RNSKTSHTVTQYQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMNEFSIlVHCLSGAGRTGVFCTAMECIAQ
|.  | .   ..  ...     . |   .   |  .. | .. |...         .|.| .  |  .. | .| .. .    |||| |.| |..  . .
gkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp..vkyaeliktaakvfakkikadentv.ivSknGaGRagafltlavavek

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
. .|. . | ..|| .|..| . |.. . |...| ..  |. 
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 655-731 1.7e-17 58.3 In-house 220-295 (297) alignment
Range on Protein: 655-731
Range on HMM: 220-295/297.0
EVKADHGQfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
 ..|.. .   .|..||||||||.|||.  | ..|  .  |. ||  ... .|..|. .||| ||. ..| |||. |
slraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 786-1026 3.9e-17 56.8 In-house 44-288 (303) alignment
Range on Protein: 786-1026
Range on HMM: 44-288/303.0
TRDNHPKNRYGNNLPLQRNRVILDspDHDYINASQMKG-IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDKSCAQ-YWPDA-NSVQFGSY
  .|  |||. . . |.  .| |   |  || || ..   .   . ||.||. | .||| .... |   |..|   |. ||   .  .|   . ..|   
fvknmdknrfvdvicldhskvkls..dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeer

SVSTLSTSSDGDMTIRQLKVTRNSKTS--HTVTQYQFHGWPkHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILV-HCLSGAGRTGVFCTAM-ECIAQIA
|.          .   .|||   |. .    .  .... || |.| |  |.  ..| |  ..|   |  . .  |   ||| ||.| |.      ..  .
sirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhs

EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQLP
|  |.|. . .. .|  |.. ||   ....|| .. |..  . . .| 
eqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla

subfamily_hpo-7_pd Subfamily hpo-7 836-1008 1.1e-16 55.6 In-house 44-218 (263) alignment
Range on Protein: 836-1008
Range on HMM: 44-218/263.0
PTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR---NSKTSHTVTQYQFHGWPKHgSDPQLgA
  |.  |.. .   |...|||| |   .  . | .|.|     .     |.  .| .  |. .. |...    . |. |||..|.. ||...  ||.| |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek.ndpel.a

RSLMKLIRAVKSStnKmnefSILVHCLSGAGRTGVFCTAmECIAQ-----IAEGD--SVDIFQTVKILRADRMQFVQTEEEYAF
|. ........ |  |    |. ||| .| ||.  |  | | . |     . . .   .|  . .. ||  | . ..|    ||
reilnilkvarns..k....slvvhcstGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

subfamily_CG42327_pd Subfamily CG42327 662-726 2.1e-16 54.5 In-house 245-310 (319) alignment
Range on Protein: 662-726
Range on HMM: 245-310/319.0
QFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
.   ||..||| ||||||.||. |  . . ... | ||. . |  .|. |   |.|.|||.|||  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_eak_pd Subfamily eak 781-1021 3.5e-16 53.5 In-house 44-309 (332) alignment
Range on Protein: 781-1021
Range on HMM: 44-309/332.0
TRSGRTRDNHPKNRYGnNLPLQRNRVILDSPD---HDYINASQMK--GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDA
 . ..  ..  .| ..  .| .|. | | |       ||||| ..   .   .. | ..  . |  || .||. |  ..|.| .. ... .   .|.|| 
isetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

N--SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSD------------PQLGARSLMKLIRAVKSSTNKM-----NEFSILV
    ..|| . | . .    . .  |.|....  .| | |  |...|| .                 . |.  |.    |. ||| |        |. ..
treelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii

HCLSGAGRTGVFCTAMECIaQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 .  |. |.|||      | .. ..    .  . . .   .  |.  | .. ...|.|... .|| . |
qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

subfamily_CG42327_pd Subfamily CG42327 789-944 4.8e-16 53.3 In-house 28-193 (319) alignment
Range on Protein: 789-944
Range on HMM: 28-193/319.0
NHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDAN----S
 ..|.|. | .||   ||.|..    .   |..|| ..|    .. ....|..|  . |||| .| . .  ..| | | |..  | ||.|.|  .     
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

VQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFhGWPKHGSDPQlgARSLMKLIRAVKSS
  .| . |.     ..    |  | . |   . |  .| | .  |.. .   .   ..|. ..  |.||
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPae..eaaliamllevrss

subfamily_hpo-7_pd Subfamily hpo-7 553-729 6.1e-16 53.1 In-house 46-225 (263) alignment
Range on Protein: 553-729
Range on HMM: 46-225/263.0
STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEActGGIKRKMTMIK--G--DDYRTVTQFHFTEWPDKGVPKHTSS
  | |.... | . ....|..  .| .. || .|.|    .  |. |..|           ...   ...  |     .||... .. |..|  |. . .
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA----H--AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 |. .| ..       ..|..|||.|.||.     ...|            |  .|  ......|..|.  ..|  | ||    ||.
ilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 668-731 6.9e-16 52.4 In-house 2-65 (69) alignment
Range on Protein: 668-731
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 827-891 6.9e-16 52.6 In-house 237-300 (440) alignment
Range on Protein: 827-891
Range on HMM: 237-300/440.0
TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDksQNDKSCAQYWP-DANSVQFGSYSVSTLSTSS
.|..||||| .|| ||| || .|. ||..|||.   |||.|. ||| .. || || ..|    .  
afiatqmpldstvldfwrlvhdyristiimlnq..lndktcsiywpvntrsvtfgpftvghkgsen

0048076 (Phosphotyrosine protein) phosphatases II 906-1016 9.5e-16 53.2 In-house 41-142 (145) alignment
Range on Protein: 906-1016
Range on HMM: 41-142/145.0
SKTSHTVTQYQFHGWPKHGSDPQ-LGARSLMKLIRAVKSStnkmnEFSILVHCLSGAGRTGVFCTAMECIAqiaegDSVDIFQTVKILRADRMQFVQTEE
.  .....||.. .|| ||  .     ......|... ..     .  .||||  | ||||... |. ..       .|....... .|. |...|....
ellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpg

EYAFVYDVIREY
 . |.|....|.
qlrflyefelel

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 833-1009 1.2e-15 51.8 In-house 98-280 (302) alignment
Range on Protein: 833-1009
Range on HMM: 98-280/302.0
MPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDGD-------MTIRQLKVTR---NSKTSHTVTQYQFHG
.|   |.  .|.|. .|. . || | . . ...| ||.|. |   . ..|| |.| |.|   | .       ... .....    ..|. .||   .| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPKHGSdPQLgARSLMKLIRAVKSStnKMnefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
||.||. |.  | . .....  .|   |    ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   ..
wpdhGa.pke.aytaldilkfcesy..kk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 788-1013 1.5e-15 51.6 In-house 51-286 (310) alignment
Range on Protein: 788-1013
Range on HMM: 51-286/310.0
DNHPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANS-VQFG
..  |||| . . |.  || |    |  .||| |  .|   .  ||. .| ||  |. ||| .... .  ....|   ... .  |  |||       .|
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

SYSVSTLSTSSDgDMTIRQLKVTRNSKT-----------SHTVTQYQFHGWPKHGSDPQLGARSLMKLIRavksstnKMNEFSILVHCLSGAGRTGVFCT
   |. || ||. .. | .| ||                   |.  ..  ||  |   .       .|.        ..     .||| .| .|..| ..
cirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla.......qvrhgpcvvhcsagkdrlyvvva

AMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
    | .. .|. ||. . .  |. .|.. .||| .| ..  | 
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 668-731 1.8e-15 51.0 In-house 1-64 (69) alignment
Range on Protein: 668-731
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

0048179 (Phosphotyrosine protein) phosphatases II 899-1011 8.3e-15 50.3 In-house 48-139 (144) alignment
Range on Protein: 899-1011
Range on HMM: 48-139/144.0
QlkvtrnsktshtVTQYQFHGWPKHGSDPQ-LGARSLMKLIRAVKSstnkmNEFSILVHCLSGAGRTGVFCTAMECIaqiAEGdsVDIFQTVKILRADRM
.            ..||.. .|| ||  .     ......|... .     ..  .||||  | ||||....|  ..    .|  ........ .|. |.
e............giqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrp

QFVQTEEEYAFVYD
. |.... . |...
gavpnpgqlrfLle

fn3 Fibronectin type III domain 240-329 1e-14 47.6 Pfam-A 2-85 (85) alignment
Range on Protein: 240-329
Range on HMM: 2-85/85.0
SPINVAIPRSTTSSFTVSWSTPLpsNINGDIQKYIIRFKQTDPVVdgdyKSEEVLNSAFEEEHTVVDLTAKTSYSVQVQTVNGAGSSNWS
.| |. .   |..|.|.||| |   . .|.|..| .......       .. |. ... ....|. .|.. |.|...||.||||| . .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 618-728 1.8e-14 48.2 In-house 207-341 (350) alignment
Range on Protein: 618-728
Range on HMM: 207-341/350.0
MTMIKGDDYRtVTQFHFTEWPDKGVPKHTSSLLKFIK-------EVK-ADHG--QFTHPLIIHCSAGVGRTGVVISIDSVVA-------------HAK-T
.|.   | |  | |...  |.| ..  .  |.|. ..       .     |   . . |...||||||||||.....||..              . . .
itlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

TRMVD-VFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
... | ..  | ..|..|  |||. .|. ||| |.|
aktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 453-537 2.4e-14 47.5 In-house 2-86 (440) alignment
Range on Protein: 453-537
Range on HMM: 2-86/440.0
SNKPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSF
|..|| .|.|  .|..|| .  | .|.  ||     |  .|    |  ||||.||| || .|| || .   |.||| ||||| . 
sqrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 726-927 7.1e-14 46.0 In-house 34-237 (244) alignment
Range on Protein: 726-927
Range on HMM: 34-237/244.0
AVLEDLLWRNTLIPVVHFTDHlQDLHSSGDGRGRSKMTKEF-QTLKS-LCPDPpaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILD--SPDHDYINASQM
|||     .|  | .. | .  . . ||    |   .  .. |  .. . |||  |  .     .|  ||| |  ||.. ||| |   |    ||||| .
avlsanatknryinilpfdet.rvilssskkegsdyinanyiqgsqniirpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv

K--GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDkscaQYWPDANSVQFGSYSVSTLSTSSDGDMTIR--QLKVTRNSKTSH-TVTQYQ
   |  . .. || ||  |  ||| ..|. .   .|.|    ..|    .||||.. ...    ..   |  |    |.  .|..  . . || ..| .|
gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfq

FHGWPKHGSDP
   ||  |. |
isnwpsdgttp

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 790-877 9.3e-14 45.9 In-house 48-156 (350) alignment
Range on Protein: 790-877
Range on HMM: 48-156/350.0
HPKNRYGNNLPLQRNRVILD----S--------PDHDYINASQMK------GIHCTF--MTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCA
  |||| | ||  ..||.|     |           |||||. .|       |   |  . || ||| || ||. ..|. |   ...|..   .| . | 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPDANSV
.||.. .  
rYWqegsyd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 498-605 9.5e-14 45.5 In-house 48-173 (349) alignment
Range on Protein: 498-605
Range on HMM: 48-173/349.0
NFTKNRYKNILPYDSARVKLEVIDNNP--------------HSDYFNASYI--PSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKI
 |.|||||.||||. .||||.   ...                || || |.  . .. .| ||| | |  .. |||....  ..|  .  ... || .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCGKYWPKIP--GDSVKFGNIKVELV
|| .|| .    .  ||. |     .
kcdiywqelsysnitvklqnsslyia

subfamily_CG42327_pd Subfamily CG42327 942-1016 1.6e-13 45.0 In-house 238-314 (319) alignment
Range on Protein: 942-1016
Range on HMM: 238-314/319.0
KS-STNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
 | | .. .   . |||  |.||||.  ..   | .. |   |||| |.|  .| || . |.| | |.|.| |. ||
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 955-1017 3.5e-13 43.7 In-house 2-64 (69) alignment
Range on Protein: 955-1017
Range on HMM: 2-64/69.0
VHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| |..| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 954-1017 4.3e-13 43.5 In-house 2-65 (69) alignment
Range on Protein: 954-1017
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || |..| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 472-548 4.9e-12 39.9 In-house 22-95 (95) alignment
Range on Protein: 472-548
Range on HMM: 22-95/95.0
TALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVidnNPHSDYFNASYIPSFDNDKAYIASQG
   | .||. ..     | ||   | |  |||. ||.|||..|| |     .  ||| || ..  .   ..|||.||
dqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

fn3 Fibronectin type III domain 75-151 1.5e-10 34.2 Pfam-A 9-81 (85) alignment
Range on Protein: 75-151
Range on HMM: 9-81/85.0
VSTTSTTVGLQWNAWSekddIGDPPLVGYDVFVKEDGDW--VTDQRVDPLPTSAIVSNLTADTEYMFRVAAVREGRggT
 ..|||.. |.|.. .     |. |..||.| ..|.|.    . ..|..  ||.....|...||| |||.|| ..   .
sevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag..e

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 949-1013 3.8e-10 34.1 In-house 227-291 (297) alignment
Range on Protein: 949-1013
Range on HMM: 227-291/297.0
NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 .  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. ..||..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 800-927 7.3e-10 33.3 In-house 4-128 (130) alignment
Range on Protein: 800-927
Range on HMM: 4-128/130.0
PLQRNRVIldspDHDYINASQM--KGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDkscaQYWPDANSVQFGSYSVSTLSTSSDGDMTI
. . .|.     ...||||| .   |    .. || ||  |  ||| ..|.     .|.|    ..|    .||||.. ...    .   .|  |.   |
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefkni

R--QLKVTRNSKTSH-TVTQYQFHGWPKHGSDP
.  .|.. .. . || ..| .|   ||  |. |
kasnleiesdlneshqaltmfqisnwpsdgttp

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 831-1017 1.1e-09 31.4 In-house 123-309 (346) alignment
Range on Protein: 831-1017
Range on HMM: 123-309/346.0
TQMPLPTTVSDFWSLVLNYKPSTVVM-LNDKSQNDKSCAQYWPDANSVQF-GSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQ
 ||   . | ||| .. . .   | . . |   .. . . .  .    |. |   .    .   ||     ..|  . ..   . | . |   ||  .| 
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqpp

LgARSLMKLIRAVKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  .  ..|.|   .|  .....  . |  | |.||.  |  |.  | |. .|   .|.. .| .. .|   |..  .|| .| .. .|.
k.tlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 911-1017 1.8e-09 31.8 In-house 216-344 (350) alignment
Range on Protein: 911-1017
Range on HMM: 216-344/350.0
TVTQYQFHGWPKHG--SDPQLGARSLM---KLIRAVKSS--TNKMNEFSILVHCLSGAGRTGVFCTAMECIA------QIAEG---------DSVDIFQT
 | | |.. |.  .   .|.   ..|    .||    .    .. .  .||||| .| ||||...|    .       .. .              |...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKILRADRMQFVQTEEEYAFVYDVIREYL
|..||  |.. ||. . . |.|. .. | 
vnelrkqrismvqnldqfifiYeallfyf

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 487-582 2.6e-09 31.0 In-house 23-117 (332) alignment
Range on Protein: 487-582
Range on HMM: 23-117/332.0
IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNnpHSDYFNASYIPSFDNDKAYIASQGPNNASTDD-FWRMVWQENVTTIAMVTKLKEGDKIK
 ||.|  .   |.  ||   .  .| .||.|   |   . |..|||..  . .  ||| .| | |  |.  ||||| . . . | ..  . | .| |
typntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 629-728 8.2e-09 29.2 In-house 220-341 (349) alignment
Range on Protein: 629-728
Range on HMM: 220-341/349.0
VTQFHFTEWPDKGVPKHTSSLLKFIKeVKADH-----------GQFTHPLIIHCSAGVGRTGVVISIDSVVA----HAK-------TTRMVDVFNFVTNI
. |. . .|.| ..     |.|. .. || |             . . .|..||||| |||||.. .|....      .        . . |.  .. |.
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

-RQKRPYMVQTQEQYAFIYGAVL
 |..|  |||   |. .|| |.|
lrkqrismvqnlaqfiaiyealL

subfamily_PTPDC1_pd Subfamily PTPDC1 631-722 1.1e-08 29.7 In-house 84-167 (182) alignment
Range on Protein: 631-722
Range on HMM: 84-167/182.0
QFHFTEWPDKGVPKHTsSLLKFIKEVKADHGQFthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRmvdvfNFVTNIRQKRPYMVQTQEQYAF
 ..   |.| ||.  . ..|  .| |.    .    . .|| || |||||.|.   | |.  |.      . .. .|.|||  .||.||  .
yvynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvel

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 813-875 1.4e-08 28.5 In-house 90-157 (349) alignment
Range on Protein: 813-875
Range on HMM: 90-157/349.0
HDYINASQMKG----IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDAN
.|||||  .|     ..  ...||.|||.|| ||. ..|. .   |. ||| | .. . | .|| . .
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 491-574 1.6e-08 28.5 In-house 30-118 (347) alignment
Range on Protein: 491-574
Range on HMM: 30-118/347.0
TVAQEEINFTKNRYKNILPYDSARVKLE-----VIDNNPHSDYFNASYIpSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTK
|... | . .||| |.    |..|| |          ..   | |||.|  ||| .| || .| |   .  |||.||   .|| .  . .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 539-602 6.8e-08 26.2 In-house 234-293 (440) alignment
Range on Protein: 539-602
Range on HMM: 234-293/440.0
NDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKegDKiKCGKYWPkIPGDSVKFGNIKV
. .|.||.| | ...  ||||.| . ...|| |. .|.  ||  |  ||| .   || || . |
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywp.vntrsvtfgpftv

0038934 (Phosphotyrosine protein) phosphatases II 631-723 1.5e-07 26.7 In-house 81-169 (194) alignment
Range on Protein: 631-723
Range on HMM: 81-169/194.0
QFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF-THPLIIHCSAGVGRTGVVIsidsvVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFI
...   .||.|..  .. ||.|.. |.  . .   .   .|| ||.||||...     .|.   ..  ..   .  .|.||| ....|...  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdyleal

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 547-729 2.5e-07 23.6 In-house 124-307 (346) alignment
Range on Protein: 547-729
Range on HMM: 124-307/346.0
QGPNNASTDDFWRMVWQENVTTIAMvtkLKEGDKIKC--GKYWPKIPGDSVKFGNIKVELVSleACTGGIKRKMT---MIKGDDYRTVTQF-HFTEWPDK
|  |..  .||| |..||..  . .   .   ||.|      .    |     |.. ..     |   |  .. |   . .|.    . |  | . |   
qmenesfvedfwymiyqeqihlvyl...mvpddklkntttslfndenggyqytgkmfinnrr..advsgdpkeytievlpegnsdsvicqvhhhapwkhl

GVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
  | .|  ..|.|.. ....   .  . .    | ||.   |     .         .... . ||.|.||  |..  ||| ||  |..
qqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 905-1017 3.8e-07 23.7 In-house 213-344 (349) alignment
Range on Protein: 905-1017
Range on HMM: 213-344/349.0
NSKTSHTVTQYQFHGWPKHGSdpQLGARSLMKLI-------RAVKS--STNKMNEFSILVHCLSGAGRTGVFCTAMECIA--QIAEGDSVD---------
...  . . | |.  |.  .    |   |... .           .    .. .  ..|||| .| |||||..|    ..  .  . .|.          
avekPyellqlqvknwldlsl..llnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

-IFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 |. .| .||  |.. ||   .. ..|. . .|.
lisiivnelrkqrismvqnlaqfiaiyealLkyf

fn3 Fibronectin type III domain 169-226 5.4e-07 22.8 Pfam-A 25-85 (85) alignment
Range on Protein: 169-226
Range on HMM: 25-85/85.0
DCRSGVTHYMIYYAAS-TS--SNSLTVPNDTSFYTIRELDTYLDYTIQLTASNKDEESDRS
| .. .|.| . |. . ..  ... |||..|. .|...|  . .|.....| |.. |. .|
dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

ODV-E18 Occlusion-derived virus envelope protein ODV-E18 355-393 8.5e-07 17.2 Pfam-A 29-67 (85) alignment
Range on Protein: 355-393
Range on HMM: 29-67/85.0
AILIILIIIIVVIIVFKRRRNDSNPSKKENIEDQFQAPL
 ||| |.||| .|..|.   |... |.... . .|. ||
tiLivlViiiLlilLfqsSSngnssssaattraaftnpl

subfamily_PTPDC1_pd Subfamily PTPDC1 929-1011 9.4e-07 23.4 In-house 93-170 (182) alignment
Range on Protein: 929-1011
Range on HMM: 93-170/182.0
LGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDsvdifQTVKILRADRMQFVQTEEEYAFVYD
 |..|| ...  ||  .  ..|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .| .
ygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvke

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 811-870 9.5e-07 22.6 In-house 68-128 (347) alignment
Range on Protein: 811-870
Range on HMM: 68-128/347.0
PDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDkSQNDKSCAQY
. . |||||..|    .  .. || ||| || ||| .|   | . || . .  ..|..  ..
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife.pikdeaieef

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 488-537 1e-06 22.6 In-house 29-77 (244) alignment
Range on Protein: 488-537
Range on HMM: 29-77/244.0
YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDnNPHSDYFNASYIPSF
. || |    | ||||| ||||.| .|| |     .  ||| ||.|| . 
flqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 863-1013 1.5e-06 21.9 In-house 146-298 (332) alignment
Range on Protein: 863-1013
Range on HMM: 146-298/332.0
NDKSCAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSDPQ--LGARSLMKLIRAVKSSTNKMNEFSILVHCLS
. | | ..||. .|  .| . |. .    |.  |   .| || . |  |     .|. |      |.  |  |. .||     |    .    |.. | .
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtek.kqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
|  .  ...|    ...|.|   | . .|.  .. .|.  ..|   |.   ...
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystaceml

0038934 (Phosphotyrosine protein) phosphatases II 919-969 3e-06 22.5 In-house 84-134 (194) alignment
Range on Protein: 919-969
Range on HMM: 84-134/194.0
G--WPKHGSDPQLgaRSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCT
   .| .|. |.|    |.. ...|.  .|. ..  ..|||  | ||||... 
klpfpddgtvPsl..eillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 489-645 3.1e-06 20.1 In-house 17-156 (169) alignment
Range on Protein: 489-645
Range on HMM: 17-156/169.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNAsyipsfdndkayiasqgpnnastddfwRMVWQENVTTIAMVTKLKEGdkikcGKYWP
 . .|.  .| ||||    |    .||||. . ..  ||| ||                           ||.|. | . | ..    .        .||
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwp

KIPGDS----VKFGN-----IKVELVSLEACTGGIKR--KMTMIKGDDYRTVTQ----FHFTEWPDKGVPKH
.         | .|.     . |    ..  | |..   ........  ..||.    .|.. ||..|||. 
ekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 488-645 4.6e-06 19.7 In-house 17-157 (169) alignment
Range on Protein: 488-645
Range on HMM: 17-157/169.0
YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNAsyipsfdndkayiasqgpnnastddfwRMVWQENVTTIAMVTKLKEGdkikcGKYW
| . .|.  .| ||||    |    .||||. . ..  ||| ||                           ||.|. | . | ..    .        .|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfw

PKIPGD----SVKFGN-----IKVELVSLEACTGG----IKRKMTMIKGDDYRT--VTQFHFTEWPDKGVPKH
|.        .| .|.     . |    ..| | |    ..  | . . ||  |  .. .|.. ||..|||. 
pekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 740-823 5.5e-06 20.5 In-house 7-83 (95) alignment
Range on Protein: 740-823
Range on HMM: 7-83/95.0
VVHFTDHLQDLHSSGDgrgrSKMTKEFqtlKSLCPDPPASHTrSGRTRDNHPKNRYGNNLPLQRNRVILDS-PDHDYINASQMKG
|  |  |. ..||  |     .. .||   ||.     |..|  | .  | ||||. | .| .  ||.| .  | |||||  . |
vsvfhshvlemhsnsd....qefdnef...ksismtsgapyt.vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdg

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 508-641 5.6e-06 20.7 In-house 3-125 (130) alignment
Range on Protein: 508-641
Range on HMM: 3-125/130.0
LPYDSARVKlevidnnpHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDkikcgKYWPKIPGDSVKFGNIKVELVSL
|... .|..          .| |||..   .. . |. .| |  ... |||.|. .  |  . ..  ..| |     .|||          .| | |   
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

EACtGGIKRKMTMIKGDDYR---TVTQFHFTEWPDKG
.     || .   |. |  .   ..| |. ..||  |
def.knikasnleiesdlneshqaltmfqisnwpsdg

EphA2_TM Ephrin type-A receptor 2 transmembrane domain 349-385 8.3e-06 17.2 Pfam-A 3-39 (75) alignment
Range on Protein: 349-385
Range on HMM: 3-39/75.0
AGGAVGAILIILIIIIVVIIVFKRRRNDSNPSKKENI
...........|...||||..|.|...... ...|. 
iasvavgvvlllvvvivvivlfrrskyskakkdseel

TMEM154 TMEM154 protein family 356-394 9.5e-06 17.0 Pfam-A 68-106 (146) alignment
Range on Protein: 356-394
Range on HMM: 68-106/146.0
ILIILIIIIVVIIVFKRRRNDSNPSKKENIEDQFQAPLD
. ..|.......|..||.|.  ....... ||. .  ||
LillllvvvilvikkkrkrrKqeetsedekedlqldeld