Gene SpurPTP-sf1-12 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP089_AA protein Get Run
SpurP089_AA_457-732 phosphatase_domain Get Run
SpurP089_AA_744-1018 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 456-908 0.0 1028.7 In-house 1-453 (515) alignment 
Range on Protein: 456-908
Range on HMM: 1-453/515.0
PIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTD
|.|||||||||||||||.||||||||||||||||||||||||||.||||||||||||.|||||||..||||||||||||||||||||||||||||.||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKE
||||.|.||||||||||||||||||||||||||..||||||||.||||||||||||||||||.|..||||.|||||||||||||||||||||||||.|||
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGD
|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.||||||||||||||
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

GRGRSKMTKEFQTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||| ||||.|
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstiv

MLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT
|||||||||||||||||||||||||||||||||||||||||||||.|||||| 
mlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 455-769 2.4e-186 612.9 In-house 1-315 (315) alignment 
Range on Protein: 455-769
Range on HMM: 1-315/315.0
KPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNAST
.|||.||||||||||||||||||||||||.|.||.|.||.|.|||.|||||||||.|||||||||||..|.|||.|||||.|.|.||||||||||..|| 
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
|||||||.||.||||.||||..||||||| .|||.  .|||.||.|||||.||||.|.|..||... |....||||||.|||||||||.|.||||||.||
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSG
|||||.|. ...|..||||||||||||||||.|||..| ||.|||||||.|.|.||||.|||.|.|||||.|||||||||||||.|.||||||||||.|.
evkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsv

DGRGRSKMTKEFQTL
||.|||||||||.||
dgsgrskmtkefetl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 455-771 1e-170 562.4 In-house 2-276 (392) alignment 
Range on Protein: 455-771
Range on HMM: 2-276/392.0
KPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNAST
.||| |||||||.||||.|||.|||||||||.||||||||.|||  |||||||||||||||||||||. |.|||.||||||||||.|||||||||| || 
qpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

DDFWRMVWQENVTTIAMVTKLKEGDkikcgkywpkipgdsvkfgnikvelvsleactggikrkmtmiKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
|||||||.|||||||||||||||||                                          ||||.|||.||||||||||.|||||||||||||
ddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfik

EVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSG
|||||.||.|||||||||||||||||||||||||||||.||||||||||||||.||||||||.|||||||||||||||||||||||||||||||||..|.
evkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstss

DGRGRSKMTKEFQTLKS
||..|||..|||..||.
dGdvrskqlkefrslka
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 774-1022 1.2e-127 420.2 In-house 29-282 (315) alignment 
Range on Protein: 774-1022
Range on HMM: 29-282/315.0
PDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-S
|||.....|..|...|..||||.|.|||...||.|    ||||.||||||..|....  .....|.||...|.|||..||..|..|.||...|...|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPD--ANSVQFGSYSVSTLSTSSDGDMTIRQLkVTRNSKTSHTVTQYQFHGWPKHGSDPQLGarSLMKLIRAVKSStNKMNEFSILVHCLSGAGRT
|.|||||  |.||.|||..|..||...|.|...|.| |||.|..|.||||.||..||..|.| |..  ||.|||..||.. |...|||.||||..|.|||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
||.....|..|||....|||.|..||.|||.|...|||||||||.||...|.|.  | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_PTPRD_pd Subfamily PTPRD 454-809 4.3e-123 406.9 In-house 2-358 (564) alignment 
Range on Protein: 454-809
Range on HMM: 2-358/564.0
NKPIPLAQFPAFVNKNR--HTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNN
.|||| |.....|.| .  . . |.||....  ..  . ..|....|  ||||.||..||. ||.|. ..... ||| |||.| .....|||||.||| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGdSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSL
 ...|||||||..|..|| |.|||.| .| || ||||.  | . ..|...|.|.. |  .  . |.... |   .. |.|.|||||.|||.|||... ||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQD
|..|..|.| . . ..|...||||||||||. | ||...  .|. ..||....|...|..|..||||.|||.||. |.|| |   || ... ....||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LHSSGDGRGRSKMTKEFQTLKSLCPDPpASHTRSGRTRDNHPKNRYGNNLPLQRNRVILD
|..  .. . ... .||| |..  ... ...  ..    |. |||. | |.|...||.|.
LaeveedtemtgleleFqrLatakeie.leefavatkpknkkknrfsnilalescrvvls
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 454-744 1.2e-119 393.9 In-house 7-297 (297) alignment 
Range on Protein: 454-744
Range on HMM: 7-297/297.0
NKPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNdkAYIASQGPNNAS
 .||||..|...|.||||| .|||||..||  ||.|||||.. .|| |.|||||||||| ||||......| |||.|||..... .   .|..| |..|.
rrpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

TDDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPK--HTSSL
 .|||.||..|.|.||.|.....|.|| || .||..    ...||.. |.| |.. ..|.|||.... ||.    | | |..|.||||| |..  ..|||
vadfWamvldeqvstivmlnddnerdk.kcaryWsdk..gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl

LKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFT
||.|.||. |..| .. ||..||.||||||||...||||||.|| .  ||.|..|. .||.|||.|||.|||.|.| |||| ||  .| |.. .|.
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 883-1024 1.5e-92 305.1 In-house 251-392 (392) alignment 
Range on Protein: 883-1024
Range on HMM: 251-392/392.0
SVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS
 ...||||||||.. .|||..|..|.|||||||||||||||||| |.|||||.|||||||.|||.  |||||||||||||||||||||||||||||||||
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegds

VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
||||||||||||||||||||||||||||||||||||||.|||
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq
subfamily_PTPRB_pd Subfamily PTPRB 453-729 1.1e-90 298.7 In-house 3-283 (293) alignment 
Range on Protein: 453-729
Range on HMM: 3-283/293.0
SNKPIPLAQFPAFVNKNR--HTALFSEEFHDLPGP-NIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGP
..||| | .| ..|.|..    . ||||...|    .   ...|....| .||||.|||||| .||||. ......||| ||.||| .   . .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

NNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSL
   ..||||||||......| |.|.| |. |.|| .|||.   ..| .|.|||.||. |  .  . |.... |... |.|.|.||| ||| |||..|..|
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

LKFIKEVKADH--GQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|.|...|.  .   . ..|...||||||||||. |..| .. . ... .||.| .|...|..| ..|||..|| ||. .||.
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 472-769 1.3e-90 298.7 In-house 19-318 (318) alignment 
Range on Protein: 472-769
Range on HMM: 19-318/318.0
TALFSEEFHDL-PGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIA
. |.|||.. | . ..   .. . |..| .|||| |||.||..||||. ..... ||| ||.||. . ..|||||.|.|     .|||||||. | ..| 
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTM--IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH-GQFTHPL
|.|...|  |.|. .|||.   .| ..|...||| .   ..  . |....   . .. |.| |.|.|.|||.|||....|||.....|.. .  . ..|.
mltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
..||||||||||| | .|... ..|   .||||..|...|..|. ||||..|| ||| ..|| |   .| .   ........|. .    |...|  |||
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq

TL
 |
rl
0051299 (Phosphotyrosine protein) phosphatases II 456-729 2.4e-90 298.2 In-house 4-284 (288) alignment 
Range on Protein: 456-729
Range on HMM: 4-284/288.0
PIPLAQFPAFVNK--NRHTALFSEEFHDLPGPNI-YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNA
.|.. ..  .|.|   ...... |||..|.  .. .....|. . |..||||..|||||. |||| |.|....||| |||||. .......|| ||| . 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI------KGDDYRTVTQFHFTEWPDKGVPKHT
...|||||||..||..| |.||| | ...|| .|||   |.|...|.|.|.|.| | . . ..|....       ... .||||.||.| ||| ||| ..
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

SSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..||.|...|.  . .  .| ..||||||||||..| .| .. . .....|||...|  .|..||.|||| ||| |.| |.||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 452-735 4.9e-90 297.3 In-house 21-303 (308) alignment 
Range on Protein: 452-735
Range on HMM: 21-303/308.0
SSNKPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQ-TVAQEEINFTKNRYKNILPYDSARVKLevidnNPHSDYFNASYIPSF--DNDKAYIASQG
 |...... ..  ...|   . |..|||..|.   .... .||. . |..|||||.|||||. ||||     ...||| ||||.. .  ......|| ||
vsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPG-DSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKH
| . ...|||||||..||..| |.||| | ...|| .|||  .| .|...|...|.|.| | . . ..|.... .  ....||||.||.| ||| ||| .
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

TSSLLKFIKEVKADHGQftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
...||.|...|.  ...  .| ..||||||||||..| .| .. . .....||||. |  .|..||.|||| ||| |.| |.|| |... 
peilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 455-765 2.9e-89 294.2 In-house 12-329 (330) alignment 
Range on Protein: 455-765
Range on HMM: 12-329/330.0
KPIPLAQFPAFVNKN--RHTALFSEEFHDLPGPNIYP-QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNN
 |.|. ..   ...     . || |||  ||  .|     .|..| |  |||. |||||| .|| | |.. ...||| |||.|  . . . .||.||| .
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI------KGDDYRTVTQFHFTEWPDKGVPKH
 . .|||||.|. . .|| |.|.||| .. || .|||.    .| .|||.||.   . .     ||. .       . .. | |.||||| ||| ||| .
etvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

TSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTD
.  .||..|.||. . | . |...||||||||||  | .|.|..  |. |.||||.|| ..|..|| ||||.||| ||| ..||  |. .| . |. .  
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

HLQDLHSSGDGRGRSKMTKE
||| |...  |  .  . .|
hlqklynkitgtdkigleee
0040438 (Phosphotyrosine protein) phosphatases II 459-768 7.6e-89 293.4 In-house 5-313 (317) alignment 
Range on Protein: 459-768
Range on HMM: 5-313/317.0
LAQFPAFVNKNRHtALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFW
| ..  ...|. .  ...|||.||.  .... .||. . |  ||||..|||||. |||| .... ..||| ||||.. ..  ...|| ||| . ...|||
lllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV
||||...||.| |.|.|.| ...|| .|||   |.....|...|.|.| | . | . |....   .... ||||.||.| ||| |||.....||.|...|
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDG
..   .  .|...||||||||||..| .. .. . .... |||.. |  .|..||..||| ||| |.| |.|| |....||.|. ..  .|. |.    .
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

RGRSKMTKEFQT
 . . ..||...
ddvklkekelkl
0046845 (Phosphotyrosine protein) phosphatases II 476-737 1e-87 289.4 In-house 3-280 (284) alignment 
Range on Protein: 476-737
Range on HMM: 3-280/284.0
SEEFHDLPGPNIY---PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNN-PHSDYFNASYIPSF-----DNDKAYIASQGPNNASTDDFWRMVWQENV
 |||. |.  ...   . .||. . |..|||||.|||||. |||| ..|.. ..|||.||||.. .     .. |..|| ||| . ...|||||||..||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TTIAMVTKLKEGDKIKCGKYWPKIpGDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG--
..| |.|.| | ...|| .||| . |.....|...|.|.| | . . ..|.... .   .. .||||.||.|.||| ||| ....||.|...|.  .   
rvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

QFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTR---MVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
   .| ..||||||||||..| .| .  . ....   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 762-1023 1.3e-87 288.7 In-house 23-290 (297) alignment 
Range on Protein: 762-1023
Range on HMM: 23-290/297.0
MTKEFQTLKSLCPdpPASHTRSGRTRDNH---PKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTV
.  .. . . ||.  |.. .... . ...   .|.|| | || ...||.|    |.|| ||.||| .||..  ..||||| ..|| ||| .||....||.
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTNKMNEFSI
|||||....||.||.||.|  ...||. || .||.|.   .  |.|.||... |. . | ||||  ||..  . .  |.||.|||  |. . .. .|  .
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
|||||.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.||| .. |.| .|...
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 454-750 6.6e-87 286.4 In-house 3-298 (315) alignment 
Range on Protein: 454-750
Range on HMM: 3-298/315.0
NKPIPLAQFPAFVNKNRHT--ALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNN
 .|||| |. ..| ... .    | ...  .|| ...|  ||..  |  |||| ||..|| .||.| ...|.||||| ||..|. ..  . |||.|||| 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpgdSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLK
|| .||||.|..|....| |.|.| ||.| |. ||||      | .|.| | ..| |  |    | .... ||. |.| |.|.| ||| ||||.| .|..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmn

FIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDL
.|. ||  | .   ....||||||||||  |..|.|. .|.. ...||.||.|..||.|  |||. ||| ||| |.|| ..  .| |    . .. . |
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 471-767 7e-86 283.2 In-house 21-319 (319) alignment 
Range on Protein: 471-767
Range on HMM: 21-319/319.0
HTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIA
 . |. .||..| ...    . |..|.| .||||.|||.|| .||.|  .|. . ||| |||.| .... ...|| |.| .  ..|||||||.|.. .. 
getllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTM-IKGDDY--RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD-HGQFTHP
|.|||.|  |.|. ||||.   . ...|.. |.| . |   . |.||... .| ..   |.|..|..|||||..||... |||...|...   ...   |
mltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEF
...||||||||||  | .| .. . |   ..|||..| ..| .|. |||..||| ||| |.|| .   .| | | .. | |..| .   . | ... .||
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref

Q
|
q
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 469-728 1.9e-85 281.4 In-house 17-276 (288) alignment 
Range on Protein: 469-728
Range on HMM: 17-276/288.0
NRHTALFSEEFHDLPG-PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVT
 |  . ||||.. |.   .   .|....  | .||||.||||||  ||||.  .... .|| ||||| . ...|.|||.|||. .. .|||..|......
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIAMVTKLKEGDKIKCGKYWPKiPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPL
||.|.|.| ||.| ||..|||.  .. ...|...|.||. .  .  ..||. . |  . ...||.... |||.|||. .  ||.... ||  . . | |.
tivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
|.||||||||||. |..| .. . ... ..||...|...|..|. .|||..|| ||| ..|
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 466-736 4.6e-85 280.5 In-house 20-295 (298) alignment 
Range on Protein: 466-736
Range on HMM: 20-295/298.0
VNKNRHTALFSEEFHDLPGPNI----YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMV
|.|. . . ...||. |   .       ..||... |  |||| .|...||.|| || .|.. .||| |||.. .... .|.||.|.| .... ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVTTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD
..|...|| |.|.|.| ||.|. ||||.    . ..|.|.|.| | |  .  |.||... | .  . |.| |.|||.|||||||....|.|.....|.| 
teedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

HGQFT-HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
. |   .|.|..|||||||.|  | ||||. ..|. ..||||. |  .|.||| .|||.|||.||| |||| |   |.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
0036941 (Phosphotyrosine protein) phosphatases II 468-742 6.4e-85 280.3 In-house 9-288 (297) alignment 
Range on Protein: 468-742
Range on HMM: 9-288/297.0
KNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLevidNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVT
..  . | .|  . ||  .... .||. . | .|||||.|||||. ||||    ....|||.||||.. .| ....|| ||| . ...|||||||..|||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEA--CTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-
.| |.|.| | ...|| .|||   |.|...|...|.|.| |   ... . |.... .  ... ||||.||.| ||| ||| ...|||.||..|.  . . 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-FTHPLIIHCSAGVGRTGVVISIDSVVAHAK---TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVH
   .| ..||||||||.|..| .| ..   .   ... ||....|  .|..|| .||| ||| |.| |.|| |....| .|.. 
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 465-729 2.5e-84 278.3 In-house 4-270 (273) alignment 
Range on Protein: 465-729
Range on HMM: 4-270/273.0
FVNKNRHTALFSEEFHDLPGPN-IYPQTVAQEEINFTKNRYKNILPYDSARVKLevidNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQ
...|  ...|. |||..|.    ... .||. . |..|||||.|||||. ||||    ....||| ||||.. ..  ...|| ||| . ...|||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

ENVTTIAMVTKLKEGDKIKCGKYWPKIPGD-SVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH
.||..| |.|.| | ...|| .|||   |. |...|...|.|.| | . . ..|.... .   ...||||.||.|.||| ||| ...|||.||..|.  .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GQ--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 .    .| ..||||||||||..| .| .. . .....|||.. |  .|..||.|||| ||| |.| |.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 464-750 5.8e-84 276.8 In-house 12-305 (307) alignment 
Range on Protein: 464-750
Range on HMM: 12-305/307.0
AFVNKNRHT-ALFSEEFHDLPGPNIYPQT-VAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMV
|.....|.|  .. .|.. |.  .|  .| |.... |  ||||..| ..|. ||||..|  . .||| |||.| .... | .||.|.| .|  .|||||.
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

WQENVTTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKG-------DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
.. .||.| |...|.| .. || ||||.   | |..|.| |.||| | ..  |.|.. . |        .| | |.|.|.|.|.|  ||... .|||.|.
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDL
.|.  . .   |...||||||||.|.....||.. . |.   ||.|..| ..|..|. .||  ||| |.| |.|.   . .| . | .. |... |
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_PTPRK_pd Subfamily PTPRK 476-768 2.4e-83 274.6 In-house 25-314 (314) alignment 
Range on Protein: 476-768
Range on HMM: 25-314/314.0
SEEFHDLPGPniypQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKL
 ||.  |.        .|... | .|||...||.|| .||.| .||..|.||| ||..| |. . .|.|. ||| .  . ||||.|..|| ..| |.|.|
keeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel

KEGDKIKCGKYWPKipgDSVKFGNIKVELVSLEACTGGIKRKMTMIK----GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHC
.|  ..|| ||||.   |. ..|.||||||. |. .  ..| ... |     ...|.| ||.|. ||| .||..  .|||....||. . .   ....||
vevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

SAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQT
||| ||||. | ||.|.  ... ..||||| | ..|.... ||.|.||| ||| ..||  |  .| ||| .|     .          |.. .||||
saGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 455-751 3.2e-83 274.4 In-house 2-303 (305) alignment 
Range on Protein: 455-751
Range on HMM: 2-303/305.0
KPIPLAQFPAFVNKNRHTA--LFSEEFHDLPGPnIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNA
|.| |... |.....| .    . .... |.     .  | ..| | .|||.|.| ..|  |..|   .....||| ||||. .... |.||..||| . 
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSL
  .||||....| |.|| |.|||.||.| || .|||.  .....||...||| | .. .. |.||... .    .. |||.|...|.|||.|||. ..||
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

LKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQ
|..||.|. |. .    ||..||||||||||| |..|  . ..|.  .||||. . ..|.||..||||..|| |.. |. | .   .| | .  .. ...
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

DLH
 |.
klk
0043336 (Phosphotyrosine protein) phosphatases II 470-729 1.2e-82 272.8 In-house 17-275 (278) alignment 
Range on Protein: 470-729
Range on HMM: 17-275/278.0
RHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTI
   .|...||..|.  .......|. . |..|||||.|||||. ||||..... ..||| ||||.. ..  ...||.|||.. ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLKEGDKIKCGKYWPkipGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPL
 |.|.|.| ...|| .|||   |.|...|...|.|.. | . . . |....   . . .||||..|.. ||| ||| ..|.||.|.|.|.       .|.
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..||||||||||..| .. .. ...... ||... |  .|..|| .|||..|| |.| |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
DSPc_SM00195 489-729 1.5e-82 272.2 In-house 17-260 (263) alignment 
Range on Protein: 489-729
Range on HMM: 17-260/263.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. | |... | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .   .|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

KIPGDSVKFGNIKVELVSLEACT-GGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISID
.  |.. .||.|.|.||. | .    |.|.... | .  . |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 489-729 1.5e-82 272.2 In-house 17-260 (263) alignment 
Range on Protein: 489-729
Range on HMM: 17-260/263.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. | |... | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .   .|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

KIPGDSVKFGNIKVELVSLEACT-GGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISID
.  |.. .||.|.|.||. | .    |.|.... | .  . |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPN12_pd Subfamily PTPN12 486-729 5.9e-82 269.8 In-house 28-275 (290) alignment 
Range on Protein: 486-729
Range on HMM: 28-275/290.0
NIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGK
..|.......| | .|||||.||||| .||.|. |.....||| ||..|   .....|||.|||  .  ||||||.|. ||. . |. .. | .|.|| .
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPKIPGDSVKFGNIKVELVSLEACT-GGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISI
|||.  .....||...|.| . .|.. . . | ... . .. |.|.|||.|.|||.|||. ..|||..|..|.  . .  .||..||||||||||..|.|
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| |    |. ..   .|||. |...|..|. .|||.||| ..| ||.|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0039614 (Phosphotyrosine protein) phosphatases II 457-736 3.3e-81 268.3 In-house 16-294 (297) alignment 
Range on Protein: 457-736
Range on HMM: 16-294/297.0
IPLAQFPAFVNKNRHTALFSEEFHDLPGPNIyPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNN-PHSDYFNASYIPSFDN-DKAYIASQGPNNAST
.    .  ...|   . |. .|| .|.  .. ....|. . | .|||||.|||||. |||| ..|.  ..||| ||||.. .|  ....||.|||.. ..
lsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

DDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPKIPGdsvKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIK
.|||||||...||.| |.|||.| .. || .|||   |   ..|...|.|.. | . | . |.... ...  ||||.|..| ||| ||| ....||.|..
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefle

EVKADHGQ--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
.|.  . .    .| ..||||||||||..| .. .. . .... |||.. |  .|..||..||| .|| |.| |.|| |....|
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 473-731 5e-81 266.9 In-house 15-276 (281) alignment 
Range on Protein: 473-731
Range on HMM: 15-276/281.0
ALFSEEFHDLPG-PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAM
| | ||...|    .  . | .... | .||||.||  || .|||..  ..| ..|| ||...|.....|.|||.|||  || ..||.|||...|..|.|
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

VTKLKEGDKIKCGKYWPkIPGDSVKFGNIKVELVSLEACTGGIKRKMTM-IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLII
||.  |..|.|| .|||  .  ..|.|...|. .. |. .  |.||...  .. . |.|.|...| |||.|||. |. ||.| |||.  .  .  .||.|
vtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||||||||. |..| .| .. ......|| . |...|..| .||||  ||.|.| |||. |
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045450 (Phosphotyrosine protein) phosphatases II 467-729 6.3e-81 267.8 In-house 21-302 (307) alignment 
Range on Protein: 467-729
Range on HMM: 21-302/307.0
NKNRHTALFSEEFHDLPGPN---IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNN-PHSDYFNASYI--------PSFDNDKAYIASQGPNNAST
..  . ... .||..|.  .   ... ..|. . | .|||||.|||||. |||| ..|.. ..|||.||||.        ...|.....|| ||| . . 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

DDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGDSVKFGNIKVELVSLEACTGGIKRKMTMI---KGDDYRTVTQFHFTEWPDKGVPKHTSSLLK
.|||||.|...||.| |.|.|.| ...|| .|||   |... .||..|.|.| | . | . |....    . .  ||||.||.|.||| |||.....||.
edFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

FIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
||.||.. ...    .| ..||||||||||..| .. .  . ... .   ||... |  .|..|| .||..||| |.| |.||
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 498-729 8.6e-80 262.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 498-729
Range on HMM: 1-235/235.0
NFTKNRYKNILPYDSARVKLeviDNNP-HSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVK
|..|||||.|||||. ||||   .... .||| ||.|. .....|..||.||| . . .|||||||||.|..|.|.|.|.| .. || .|||.  ..|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGNIKVELV-SLE-ACTGGIKRKMTMIKGDDY---RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA
.|.|||||. . . .... . ||... | ..    |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 498-729 8.6e-80 262.9 In-house 1-235 (235) alignment 
Range on Protein: 498-729
Range on HMM: 1-235/235.0
NFTKNRYKNILPYDSARVKLeviDNNP-HSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVK
|..|||||.|||||. ||||   .... .||| ||.|. .....|..||.||| . . .|||||||||.|..|.|.|.|.| .. || .|||.  ..|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGNIKVELV-SLE-ACTGGIKRKMTMIKGDDY---RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA
.|.|||||. . . .... . ||... | ..    |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 491-731 1.1e-79 262.2 In-house 2-242 (250) alignment 
Range on Protein: 491-731
Range on HMM: 2-242/250.0
TVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIkCGKYWPKi
.||..  |  |||| .|...||.|| ||  . . .||| |||.. ..|. ||.||.||| .|.. ||||||..|...|| |.|.||| .|  . .|||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.

pGDSVKFGNIKVELVSLEACTGGIKRKMTMIKG--DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSV
   . |.|...|.| | |  .  .|||. . |    | |.| |.||. |||||||... . |...|.|.| . |  . |.|..|||||||.|  | ||.|
.ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
. ..|. ..||||...  .|..|| .|...||| |.| ..|. |
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 469-766 1.1e-76 253.0 In-house 19-323 (325) alignment 
Range on Protein: 469-766
Range on HMM: 19-323/325.0
NRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMV--WQenv
 .    |. ||  ||  .   ..||    |  |||.||....| .|| ||  ...|.|||.||||. .. . . ..|.| |. |...|.||.|  |.   
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

TTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTM--IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT
... .|.   ...| .| .||||  |.|..|| ..|.|...|  .  ..|.. .  .|. . |.| ||..  |.| ||.|. ..|. ... ||| . . |
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

H------PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRG
       |...||||||||||| ||. |..|.  .   ||.|.|| ..|..|| ||.| .|| .|| |. | ..  || .||  |  .|  |.       
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltq

RSKMTKEF
. .. |||
klniekef
0050432 (Phosphotyrosine protein) phosphatases II 726-1019 5.7e-76 251.1 In-house 7-301 (308) alignment 
Range on Protein: 726-1019
Range on HMM: 7-301/308.0
AVLEDLLWRNTLIPVVHFTDHLQDLHS-SGDGRGRSKMTKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILdSPDHDYINASQMKGI
|.|| ||.|.| |.|.... ...||.    .  ..... .||..| |..|      .....  .|..|||| . ||. ..||.| ....|||||| ..| 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgy

----HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDA---NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQY
     ..|  || |||.|| ||| .| ... ...|||..  .|. . ||||||.    .|...| ..| .||. ...|.|.|.|..|  ... |.|||..
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthf

QFHGWPKHGSDPQlgARSLMKLIRAVKSSTnkmNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
....|| ||  |.  ...|......|..|    ..  |.|||  | ||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | |.|... |
hytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

YLHT
||..
ylkl
0040439 (Phosphotyrosine protein) phosphatases II 489-729 9.7e-76 249.9 In-house 2-244 (249) alignment 
Range on Protein: 489-729
Range on HMM: 2-244/249.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. .||. . |  ||||..|||||. ||||..... ..||| |||||. ..  ...|| ||| . ...|||||.|....|.| |.|.|.| ...|| .|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

KipGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVISI
   |.|...|...|.|.| | . . . |....   . .. |||.....| ||| |||.....||.||..|.  . .    .|...||||||||||..| .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. .. . .... ||... |  .|..||..||..||| |.| |.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 474-735 8.2e-75 247.1 In-house 20-291 (563) alignment 
Range on Protein: 474-735
Range on HMM: 20-291/563.0
LFSEEFHDLPG---PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHS-DYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTI
 |||||..|     ..  . . .|.. |  |||| ||..||..||||. . .. .. || ||.||  .   ||.||.||| .  .||||||.|..||..|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMIK-----G---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG
 |.|.|.|  . ||  ||||   .|...|...| |.. |  .   .|.... .     .   |. ..|.|.|.|.|||.|||.|.   |.|.|  .| . 
vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

QFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
. . |...||||||||||. | .|...   ..  .|.||.|.  || .|...|||.||| |.. |.|| .. ..
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_PTPN6_pd Subfamily PTPN6 472-728 1.4e-73 242.5 In-house 25-294 (306) alignment 
Range on Protein: 472-728
Range on HMM: 25-294/306.0
TALFSEEFHDLP---GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEvIDNNPHSDYFNASYIP--SFDNDKAYIASQGPNNASTDDFWRMVWQENV
 | |.|||..|      . . .. ..   | .|||||||||.| .||.|.  .. | ||| ||.||   . ..||.|||.||  ..   |||||||||| 
kagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

TTIAMVTKLKEGDKIKCGKYWPKIPGDSVkFGNIKVELVSLEACTGGIKRKMTMI---KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF
. | |.||  |  | || .|||.   ..  .|.|.|. || .. .  | |....    |... |.| |.||..|||.||||... .|.|...|.. . ..
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

T----HPLIIHCSAGVGRTGVVISIDSVVAHAKT---TRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.     |...|||||.|||| .| || ..   ..      .|. ..|  .|. |  .|||..|| |.| |. 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0051299 (Phosphotyrosine protein) phosphatases II 735-1017 3.5e-73 241.9 In-house 2-286 (288) alignment 
Range on Protein: 735-1017
Range on HMM: 2-286/288.0
NTLIPVVHFTDHLQDLHssgdGRGRSKMTKEFQTLKSLCPDppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--IHCTF
.| |.| ....... |.     .| ... .||..| ||.||    ......   |..|||| . ||. ..||.| .    ...|||||| ..|  . ..|
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

MTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-----NSKTSHTVTQYQFHGWPK
. || |||.||.||| .| ... ...|||..   .. . ||||||. .|...| ..| .||. ...|.|.|.|.||.      ...|.|||......|| 
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

HGSDPqlGARSLMKLIRAVKSSTNkMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||  .   ...|....|.|... .  ..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.. |||.| | |||... |||
hgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0042113 (Phosphotyrosine protein) phosphatases II 492-729 1.1e-72 239.7 In-house 3-241 (245) alignment 
Range on Protein: 492-729
Range on HMM: 3-241/245.0
VAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKip
||. . | .||||..|||||. |||| .......||| ||||.. ..  . .||.||| . ...|||||.|....||| |.|.. | ...|| .|||   
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLIIHCSAGVGRTGVVISIDSVV
|.|...|...|.|.| | . . . |....   . | .|.|...|.. ||| ||| ....||.|...|.        .|...||||||||||..| .. ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

AHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 ...... |.... |  .|..|| .|||..|| |.| |.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 461-729 3.7e-72 237.9 In-house 5-288 (297) alignment 
Range on Protein: 461-729
Range on HMM: 5-288/297.0
QFPAFVNKNRHTALfSEEFHDLPGPNIYP-QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWR
.. |.|.....  | |.|. ..   ..    ....   | .||||...| ||..||.|. .|....||| ||...  . . ||.|| ||| .  ..||||
elvayvkekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK
|||...| .| |.|.. |  ..|||.|||.  ..| .||...|. |. |      .|....   | .. |.|| | |. ||| |||. ..|||.....|.
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

ADHGQFT-------------HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
   ....              |...|||||.||||  |..|  ... ... .|||.. |  .|..| ...||.|||.| | ||||
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 484-752 8.3e-72 237.2 In-house 47-312 (319) alignment 
Range on Protein: 484-752
Range on HMM: 47-312/319.0
GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTklkegdKIKC
|.|   || |  . |  |||. |||..| ..|||| ..    ||| |||..  . . . |||.||| . . .|||||.|. |..|| ..|      | ||
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkc

GKYWPKIPGDSVKFGNIKVELVslEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRT
 .|||.      . ...||..|  | .   . |.. . .     | | .|||||  |||.|||...| |....| |.  . .    .....|||||||||
sqywplkivikeerfkvkvdsv..eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHS
|| | .| ..   |  ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| .
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
0045098 (Phosphotyrosine protein) phosphatases II 475-733 1.8e-71 236.1 In-house 10-274 (278) alignment 
Range on Protein: 475-733
Range on HMM: 10-274/278.0
FSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKlevidnnphsDYFNASYIPSFdnDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTK
..| .. |. ....  |.|. . |. |||||.|||||. |||          || |||||...  .|..|| ||| .  ..|||||.|....|.| |.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMI------KGDDYRTVTQFHFTEWPDKGVPKHT--SSLLKFIKEVKADHGQ----
|.|....|| .|||   |.|. .|...|.|.| | .   ..|.....      ...  |.||..|.. ||| ||| ..  .|.|........ . .    
lvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------FTHPLIIHCSAGVGRTGVVISIDSVVAHAktTRMVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLEDLLW
           .| ..||||||||||... .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0046845 (Phosphotyrosine protein) phosphatases II 762-1019 2.4e-71 235.8 In-house 2-276 (284) alignment 
Range on Protein: 762-1019
Range on HMM: 2-276/284.0
MTKEFQTLKSLCPDPPaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGI-------HCTFMTTQMPLPTTVSDFWSLVLNY
. .||..| || ...   ... ..   |. |||| . ||. ..||.|.|     .|.|||||| ..|        ...|. ||.|||.|| ||| .|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTVVMLNDKSQNDK-SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSST
. ...|||..  .|..  ||||||. . ....| ..| .||.  ..|.|.| |..|..  .. |.|||......|| ||  |.  ...|....|.|... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrell

NK-MNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
..  ..  |.|||  | ||||.|.... .. |. ...    ||....|| ||  |...|||.| | |||... ||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 493-729 5.7e-71 233.4 In-house 2-238 (239) alignment 
Range on Protein: 493-729
Range on HMM: 2-238/239.0
AQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKip
|.. .| .|||| ||. || .|| || . |.||||| ||||.  .|   |||||.||  ..|. |||||.|||    | |.| | || | || .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..

gDSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVA
  . |. |..| |   |  .  | | . | .    . | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... 
.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||  . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 493-729 7.1e-71 233.1 In-house 3-239 (239) alignment 
Range on Protein: 493-729
Range on HMM: 3-239/239.0
AQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKip
|.. .| .|||| ||. || .|| || . |.||||| ||||.  .|   |||||.||  ..|. |||||.|||    | |.| | || | || .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..

gDSVKFGNIKVELVSLEACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVA
  . |. |..| |   |  .  | | . | .    . | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... 
.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||  . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 484-751 7.7e-71 233.9 In-house 11-275 (284) alignment 
Range on Protein: 484-751
Range on HMM: 11-275/284.0
GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTklkegdKIKC
|.|   || |  . |  |||. .||..| ..|||| .. .  ||| |||.|  . . . |||.||| . . .|||||.|. |..|| ..|      | ||
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

GKYWPKIPGDSVKFGNIKVELVslEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRT
 .|||.      . ...||..|  | .   . |.. . .     | |...||||  |||.|||...| |....| |.  . .    .....|||||||||
sqywplkivikeerfkvkvdsv..eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLH
|| | .| ..   |  ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| 
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 736-1021 1e-69 230.1 In-house 3-294 (298) alignment 
Range on Protein: 736-1021
Range on HMM: 3-294/298.0
TLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIHC--TFM
| | . ... .|| | .     . .....|||.|.|   . .. ... .|...|. |||| . ..|.  ||.| .     . |||||| ... .   .|.
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafi

TTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDP
.|| ||..||.||| .| ... .|.|||..  . ||  . .|||| .. ..|. .|| ||. . .|...|.|||.... .....| | .|  || .|   
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe

QlgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.  |.|...|.| |. |...  . ...|.| .| ||.| |.     . .. .  .||.||.||.||..|.. |||||.|.|.|... |.|.. |
n..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
DSPc_SM00195 762-1017 1.3e-69 229.8 In-house 2-262 (263) alignment 
Range on Protein: 762-1017
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
. .||..|..  ..    .|....   |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| .|.. | ...|
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMnE
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|.|..| .  .....|||||...||.|| .    ..|...|.||||.|...  .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.s

FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 762-1017 1.3e-69 229.8 In-house 2-262 (263) alignment 
Range on Protein: 762-1017
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
. .||..|..  ..    .|....   |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| .|.. | ...|
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMnE
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|.|..| .  .....|||||...||.|| .    ..|...|.||||.|...  .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.s

FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 496-729 1.7e-69 228.8 In-house 18-262 (270) alignment 
Range on Protein: 496-729
Range on HMM: 18-262/270.0
EINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFD-NDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGD-
  . . |||..|||   .||.|| ....... |.|| |.. || ..|.|||..|| .... .||||.|.|.||.|.|.|.|.|  . || .|||. |.. 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-SVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTS------SLLKFIKEVKADHGQFTH--PLIIHCSAGVGRTGVVISI
 ....|.|||  .| |  .| |...... .  . | .. |....|||.|||...       .||| ...|.. . .. .  ||..||||||||||..| .
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| .|   ..|. ||| . ....|..|. .||. |||.|.| ||.|
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0047943 (Phosphotyrosine protein) phosphatases II 757-1017 2e-69 229.4 In-house 9-272 (273) alignment 
Range on Protein: 757-1017
Range on HMM: 9-272/273.0
RGRSKMTKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTV
 |.... .||..|.||.|      .. ..  .|. |||| . ||. ..||.|.....|||||| ..|  .  .|. ||.||| || ||| .| ... ...
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLNDKSQNDK-SCAQYWPDAN---SVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM-
|||..  ....  ||||||. .   |...| ..| .||. ...|.|.|.|..|. ... |.|||.....||| ||  |     ||...|..|..  ..  
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkalealp

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.  |||.| | |.|... |||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 758-1021 3.8e-69 228.6 In-house 11-281 (297) alignment 
Range on Protein: 758-1021
Range on HMM: 11-281/297.0
GRSKMTKEFQTLKSLCPDPPashTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
..... |||..| .| ....   .. ..  .| .|||| . ||. ..||.||....|||||| ..| .   .|. || |||.|| ||| .|.... ...|
flalllkefeellpllllgs...lsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSS--DGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM-
||..  ....  ||||||.   .|...| ..| .||...  ..|.|.|.|.||  ... |.|||.....||| ||  .   ..||...|..|..  ... 
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllp

NEFSILVHCLSGAGRTGVFCTAMECIAQIA---EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
..  .||||  | ||.|.|..|  .. |.    .   |||...|| ||  |.. |||.| | |.|... |.| . .
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
subfamily_PTPRD_pd Subfamily PTPRD 777-1023 9.8e-69 227.4 In-house 36-287 (564) alignment 
Range on Protein: 777-1023
Range on HMM: 36-287/564.0
PASHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQ
. ..... .   | .|||| | ..  ..||.|      .. |||||| ..| .   ... || ||..|..||| .| ... ||.|||.  . ..|  |..
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKV-TRNSKTSHTVTQYQFHGWPKHGSdPQLGaRSLMKLIRAVKSSTnKMNEFSILVHCLSGAGRTGVFC
|||. .. ..|.. |.  ..    |..||..|. . .|. |..|.|..|  || ||  |. . .||..||| |.... . ..  |.||| .| ||||.|.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv.pesa.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
.   .. .| | . |||.|.|| ||..|   ||||| |.|....| |.|.  | |
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0037934 (Phosphotyrosine protein) phosphatases II 491-729 8.3e-68 223.8 In-house 3-240 (243) alignment 
Range on Protein: 491-729
Range on HMM: 3-240/243.0
TVAQEEINFTKNRYKNILPYDSARVKLevidnNPhSDYFNASYIPSFDNdkaYIASQGPNNASTDD----FWRMVWQENVTTIAMVTKLKEGDKIKCGKY
..|. . | .||||..|||||  ||||     .. |||.||..|. ...   .||.||| . ...|    ||||.|....|.| |.|.|.| ...|| .|
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPkipgDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD----------HGQftHPLIIHCSA
||    ..| .|...|.|.| | . . . |....     .| .|.|...|.. ||| ||| ....||.|..||..           ...  .|...||||
wp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsa

GVGRTGVVISIDSVVAHAkttRmVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLE
||||||..| .. .  .    . ||... |  .|..||. .|||..|| |.| |.||
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 757-1017 8.7e-68 224.3 In-house 29-289 (297) alignment 
Range on Protein: 757-1017
Range on HMM: 29-289/297.0
RGRSKMTKEFQTLKSLCPDppashTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSLVLN
 ..... .||..|.|| ||     .. ..   | .|||| . ||. ..||.| .     .|.|||||| ..| ..   .|  || ||| || ||| .| .
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKPSTVVMLNDKSQNDKSCAQYWPDANSvQFGSYSVSTLSTSSDGDMTIRQLKVTRnSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM
.. ...|||..   ... ||||||.  . ..| ..| .|..  ....|.|.|.||. .. |.|||..|..||| ||  |   ...|......|..  .. 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvpp..slellleflelvrealael

-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 ..  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | |.||...|.|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPN13_pd Subfamily PTPN13 477-731 1.1e-67 223.2 In-house 15-269 (273) alignment 
Range on Protein: 477-731
Range on HMM: 15-269/273.0
EEFHDLPGPNIY-PQTVAQEEINFTKNRYKNILPYDSARVKLEviDNNPhsdYFNASYIP--SFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVT
|||..|         .|.... | .||||.|.|||| .||||.  |. .   | |||.|     ..   |||.|||   ...|||.|||. ... |||||
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg..degg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLKEGDKIKCGKYWPKIPGDSVKFGN-IKVELVSLEACTGGIKRKMTMI--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqFTHPLIIH
. ||..|.|| .|||.. ....|  | ..|||. ..   |   |.....  .  . | |....|..||| |||... .||.|..||.  .   . |...|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||.||.|..|.|| |.   .  . .|| . | ..|..|  .|||..|| |.| |.|| |
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 473-728 1.4e-67 222.7 In-house 5-265 (274) alignment 
Range on Protein: 473-728
Range on HMM: 5-265/274.0
ALFSEEFHDLPGpNIyPQTVAQEEINFTKNRYKNILPYDSARVKLEVID-NNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIA
  . .|| .||  |  .|   .   . ||||||.||| . .|| ||  . ... |.| || ||  .|. .|||.| |||     .|||||..||.|. | 
kdlekeflelPl.nf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTKLKEGDKIKCGKYWPKIPGD--SVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHP--
|.||||| .. || .|.|.  .   | ..|..... ..   . .   ||... .  . |.|. . .|.|||. .|.....||....||. .. . ...  
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakla

-LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  ..|||||.||||. |.|.  | . . . .|||.. |.|.|..|  ||||.||| .|. |. 
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_PTPN3_pd Subfamily PTPN3 491-729 1.6e-67 222.4 In-house 34-273 (280) alignment 
Range on Protein: 491-729
Range on HMM: 34-273/280.0
TVAQEEINFTKNRYKNILPYDSARVKLEvidNNPHsDYFNASYI----PSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKY
..|.   | .||||..|||||..||||.   ...  || ||.|.    || .  . |||.||| . .. |||.|||......| |.| | |  ..|| .|
saarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPKiPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISI
||. ..|....|...|.. . .. .  . |.... . .  . |...|. ...|||.|||......|.|...|.. .   ..|...|||||.|||||.| .
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.  .|   ... | . . | ..|..|  .|||..|| |.  |.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 498-729 2.1e-66 218.6 In-house 3-237 (237) alignment 
Range on Protein: 498-729
Range on HMM: 3-237/237.0
NFTKNRYKNILPYDSARVKLEVIDNNphSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPgDSVK
|  |||| ||  || .|| |.   ..  ||| ||.|. .||   | |||.||| ..| ||||.|||||. . | |.| | ||...|| ||||.   .   
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

FGNIKVELVSLEACTGGIKRKMTMIKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV--KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA
.| . | |   |. .    | ... |     . | . |..|| |||.|||..|..||.| |..  .. | . . | ||||||||||||... ||... .|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|  ..||..|.| .| . |||..||..|| ||. ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0040438 (Phosphotyrosine protein) phosphatases II 741-1018 3.2e-66 219.1 In-house 3-277 (317) alignment 
Range on Protein: 741-1018
Range on HMM: 3-277/317.0
VHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDppasHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGI--HCTFMTTQMP
... ..|.||. |.      .. .||..| || .|    ... ..  .|..|||| . ||. ..||.| ..    |.|||||| ..|     .|  || |
ldlllalldllksdf....talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgP

LPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGAR
|| || ||| .| ... ...|||..  .. .. ||||||. .....| ..| .||.  ....|.|.|.|.  ....|.|||.....||| ||  |    .
lpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spd

SLMKLIRAVKSSTNkMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
.| ....||... .  ..  .||||  | ||||.|..|  .. |. ..  ||....|| ||. |.. |||.| | |.||...||| 
llldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 738-1023 5.2e-65 214.6 In-house 2-286 (318) alignment 
Range on Protein: 738-1023
Range on HMM: 2-286/318.0
IPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSlCPDPPASHtRSgRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGIH--CTFMTT
|.| .. .|.. |..     |. ....|.. |.  ... ..|. .|  .  |. |||| | |. .. || |.    ... |||||. . | .   ... .
isvedleshvrrlre....sGelllseeyerlsr.seetvtsl.ks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFHGWPKHGSDPQL
| ||| |..||| .| . . ...||| ....   . ...|||. .| ..|.  |   .. . .|...|..||||. .. | .| ||..  || .|.  . 
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

gaRSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
   ||..|.| |..  .| ..  |.||| .| ||||||..    . .|..   ||.||||| ||  |   ||||. | |.|||. |.|.. . |
..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 457-732 5.3e-65 214.2 In-house 2-279 (287) alignment 
Range on Protein: 457-732
Range on HMM: 2-279/287.0
IPLAQFPAFVNKNRHT--ALFSEEFHDLPGPNIYP--QTVAQEEINFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYIPSFDNDKAYIASQGPNNA
||. .|  ||.|....    |.. |  |   .  .   |..  . |  |||...||..|  || |.    . | || ||..| .. ..||.|....|   
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipGDSVKFGNIKVELVSLEACTGGIKRKMTMIK---GDDYRTVTQFHFTEWPDKG-VPKHTSS
   .||......|||.| |....|| |. .| .|||.  ..|| .|. ..||.. |  .| |.||. ...    .| ..|.|...|.|...| |... ..
tarnfWkliddrnvtaivmlcqekendeevcyqyWpe..eksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
|| . . .|... .   ....|||..|||... ....  . ..||   .|||. . . |...| .||| ||| ||. .||| | 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 457-730 2.6e-64 211.9 In-house 2-282 (290) alignment 
Range on Protein: 457-730
Range on HMM: 2-282/290.0
IPLAQFPAFVNKNR--HTALFSEEFHDLP-GPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPH--SDYFNASYIPSFDNDKAYIASQGPNN
||. .|  || ...   .  | ..|. |  | . .  ||.  . | ..||..||..||  |. |  | ...    .| ||.||  . ..|.||| ||| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDD---YRTVTQFHFTEWPDKG-VPKHTS
    |||...|||.|| | |.|. .| .| || .|||.   |. ..|.....|.. |.... |.||. . . .     ..|||...| |...| |.....
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

SLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
.|| . . .|  . .  .....|||..|||..| ....  . ..||.  .|||. . . |...| .|||..|| .|.  ||. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 770-1020 6.9e-64 210.9 In-house 29-286 (305) alignment 
Range on Protein: 770-1020
Range on HMM: 29-286/305.0
KSLCPDppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLN-DKSQ
|||. .   . .  |..  |. |||. .. .|. .|.||      .|.|||||| ..| .   .....| ||..||.||| |....|.||.|||   . .
kslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveg

NDKSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCL
... | ||||.. .   .||..||   |...  | ..|.||..   ..| |.||.|||.  || ||  ||  | ||..||. |. . .| .. ..|||| 
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGv.pqf.atsllslikrvqkdqkkdkgvpllVhCs

SGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 | ||||||..    . .. . ..||.|. .| ||  ||. ||| ..| |..|.. |.... 
agvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
0045450 (Phosphotyrosine protein) phosphatases II 758-1017 9.7e-64 211.3 In-house 25-304 (307) alignment 
Range on Protein: 758-1017
Range on HMM: 25-304/307.0
GRSKMTKEFQTLKSLCPDPpASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKG----------IHCTFMTTQMPLPTTVSDF
..... |||..|.|.....   ......   |..|||| . ||. ..||.| |     .|.|||||| ..           .  .|. || ||| || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSLVLNYKPSTVVMLNDKSQNDKS-CAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLI
| .. ... ...|||..   ...  ||||||| ... ..| . | .||.. ....|.|.|.||.   .. |.|||.....||| ||  |     .| ..|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldfi

RAVKSSTNKM-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
..|..  ..  ..  .||||  | ||||.|..|  .. |. ..     ||....|| ||. |.. ||..| | |.|....|.|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 740-1017 1.3e-63 210.4 In-house 4-277 (278) alignment 
Range on Protein: 740-1017
Range on HMM: 4-277/278.0
VVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPdppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGI--HCTFMTTQM
| .. ..|..|. ..  .    . .||..| |  .     ... ..  .|..|||| . ||. ..||.|.. .    .|||||| ..|     .|  || 
vkdllkallelllnlktl....lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqg

PLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPdANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGA
||| || ||| .| ... .|.|||..   .. . ||||||  .|...| ..| .|.. ...|.|.|.|.||.  .. |.|||.|...||| ||  .    
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..sl

RSLMKLIRAVKSSTNkMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 .|.....||..  .  ..  .||||  | ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | |.|....|||
sllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 789-1013 2.4e-63 209.0 Pfam-A 1-233 (235) alignment 
Range on Protein: 789-1013
Range on HMM: 1-233/235.0
NHPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWP--DANSVQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| .|...| ...|||..  . ... ||||||  . .|...|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSTL-STS-SDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTnKMNEFSILVHCLSGAGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||   .  ..||..|||.|..|. . .. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 ....||..|.|| ||. |.. ||..|.|.|.|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 789-1013 2.4e-63 209.0 In-house 1-233 (235) alignment 
Range on Protein: 789-1013
Range on HMM: 1-233/235.0
NHPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWP--DANSVQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| .|...| ...|||..  . ... ||||||  . .|...|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSTL-STS-SDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTnKMNEFSILVHCLSGAGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||   .  ..||..|||.|..|. . .. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 ....||..|.|| ||. |.. ||..|.|.|.|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPN23_pd Subfamily PTPN23 492-730 3.8e-63 208.0 In-house 37-279 (288) alignment 
Range on Protein: 492-730
Range on HMM: 37-279/288.0
VAQEEINFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYIPSFDND-KAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKI
.|  ... .|||...|||||..||||.    . . || |||.. .       .||.|.| . .  |||.||... . .| |... .| .| |. .|||. 
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

PGDSVKFGNIKVELVSLEACTGGIKRKM--TMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA----DHGQFTHPLIIHCSAGVGRTGVVISI
 |..||||...| | | .     ..|..  .. . |  ..|.  ..|.||. |||.  ..||.|..||..     . .   ||..|||||||||||.  .
kgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 ..|.   |   ..|. . |  .|..| .|||..||. | | |||| 
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 755-1015 8.1e-63 207.2 In-house 16-277 (288) alignment 
Range on Protein: 755-1015
Range on HMM: 16-277/288.0
DGRGRSKMTKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLN
. |.|. ...|...| .|      . .  ||   |..|||| | ||.  .|| |.     .. |||||| ..| .   ....|| ||. || ||| || .
sarnrtgfseeynsLaalek...tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YKPSTVVMLNDK-SQNDKSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVTrNSKTSHTVTQYQFHGWPKHGsDPQlGARSLMKLIRAVKSsTN
.| ||.|||..   .... | .|||||.  ...||  |  ...   .|.. |.| .   .||  ..||||. .|| ||  |.  .. |..|.| ||  .|
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhg.vPe.skapllellrqvkv.an

KMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
. .   |.|||  | ||||.| ..   | .. | | .|.. ||. ||  |...|||.. | |.|.|. .
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 735-1021 4e-62 205.1 In-house 2-287 (319) alignment 
Range on Protein: 735-1021
Range on HMM: 2-287/319.0
NTLIPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSLCPDppasHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTF
.| |.| .. ..|. |.|     |  .. |||..||   .|    ...|  . .|..|||| | |. .| ||.|    .... |||||| . | .    |
dteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekf

MTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTS--HTVTQYQFHGWPKHGS
. || || .|..||| .| ... |.||||.. ... |  . .|||..| ...| . |  ..     |. ||.||. ..|      .|...|.  || |. 
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv

dPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 |.  |.||..|.. .. |..| ..  | |||  |.|||| |..    . .. |   .|.|.||. ||. |   ||..| | |.|....|.... .
.Pek.atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 784-1019 8.2e-62 203.6 In-house 4-244 (250) alignment 
Range on Protein: 784-1019
Range on HMM: 4-244/250.0
GRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDKSCAQYWPDANSV
..  .|. |||| . ..|.  ||.| . .     |||||| ..| .   .|..|| ||..|. ||| .||..| .|.|||.. ....| . ||||  .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQ
..|.  || ||.   .|.|.|.||.....|... .| |..|  ||  |  |.  |.. ..|.. |..| .. ..  ..|.| .| ||.| |..    . .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv.Pev.atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
. .   ||.|. .|.||.||.. |...| | ||| .| ..| .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPRB_pd Subfamily PTPRB 738-1021 2e-60 199.3 In-house 7-289 (293) alignment 
Range on Protein: 738-1021
Range on HMM: 7-289/293.0
IPVVHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDPPAShtrSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTT
| . .|..|......  |     ....|...||..  |   .   . ..  |. |||| | || . .|| |    |... |||||. ..| ..   |..|
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqavk...aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRnSKTSHTVTQYQFHGWPKHGSdPQl
| |||.|| ||| .|.. | |..||| .   . |  | .|||.  ..|..|. .|. .....  | .||.||... .|....|.||.|  || ||  |. 
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgv.Pe.

GARSLMKLIRAVKSST-NKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 ...|....|.|.... .....  |.||| .| ||||.| .  . . .| | | |||| .|  || .|...||||..| |..... ..|....
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_PTPRK_pd Subfamily PTPRK 785-1015 2.5e-60 198.9 In-house 39-275 (314) alignment 
Range on Protein: 785-1015
Range on HMM: 39-275/314.0
RTRDNHPKNRYGNNLPLQRNRVILDSPDHD----YINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDANSV
.  .|. |||.|. |.  | ||.| . | |    ||||. . . .    |. || ||. || ||| ||.... ...|||..  ..    | .|||.  .|
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

qFGSYSVSTLSTSSDGDMTIRQLKVTR---NSKTSHTVTQYQFHGWPKHgSDPQlGARSLMKLIRAVKSSTNKmNEFSILVHCLSGAGRTGVFCTAMECI
 .|   |  ..|. . .. .| ..|..   . .  ..| |.|| |||.|   |.  |..|.||.| ||.|... ..  |.|||..||||||.|..    .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPv.satgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  | . . ||.|..|| ||. .. .|.||| | |.|||| |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0045098 (Phosphotyrosine protein) phosphatases II 776-1018 7.7e-60 198.0 In-house 20-273 (278) alignment 
Range on Protein: 776-1018
Range on HMM: 20-273/278.0
PPASHTRSGRTRDNHPKNRYGNNLPLQRNRVIldspdhDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDA
.. |    .  ..| .|||| . ||. ..||.      |||||| ..| . .|  || |||.||.||| .. ... ...|||..  ..  . ||||||. 
gipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-----NSKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTN---KM---------NEFSILVHC
.|...| ..| .||..  .|.|.| |.||      .. .|..||......|| ||. ..   .|. .|.. ...  .   ..         ..  .||||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

LSGAGRTGVFCTAMECIAQIaeGDSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYLH
  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | |.|....|.|.
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 470-742 1.3e-59 196.4 In-house 6-277 (283) alignment 
Range on Protein: 470-742
Range on HMM: 6-277/283.0
RHTALFSEEFHDLPGPNIyPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNnphsDYFNASYIP---SFDNDKAYIASQGPNNASTDDFWRMVWQENV
    || | .. |  |.  . ..|  . | .|||...|.|.|  ||.|.   .    || ||..||   | ..|| ||..|.| .    |||.||..|..
nnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

TTIAMVTKLKEGDKIKCGKYWPKIpgDSVKFGNIKVELVSLEACTGGIKRKMTMIKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF
|.| |.|||.|. .||| .||||    |...|.  | |    .    |...... .     .   .. . . .| . |      ||.|| | .     . 
taivmltklqedlrikCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVH
  |...|||.|.|||.| |.. . | .|.|  .||||. |...|..|. .|||..|| ... .|||. |  .| |  | 
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 467-745 2e-59 196.2 In-house 15-293 (439) alignment 
Range on Protein: 467-745
Range on HMM: 15-293/439.0
NKNRHtALFSEEFHDLPG--PN-IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQ
.||..  .|.|.|. .    |.     ..| .| . ||||||.. ..| .|| |. |   ||| |.|| ||  . .|| |||.|||.. .||||||.|..
dknkq.eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

ENVTTIAMVTKLKEGDKikcgkYWPKipGDSVKFGNIKVELV---SL-EACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-A
....|| |.|.| |  |     |||    . | .|.| |       | . .  |.|      ...  ||| |||.. |||| || ..| .|.|.. .. |
kktvtivmltnlvesyk.....ywps..daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa

DHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTD
.  . . |...|||||||||| .|..|  . . |.   ||.   |. .|..|  |||.  || ||| |||||. . .. . . .|  
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
0040439 (Phosphotyrosine protein) phosphatases II 784-1017 3.1e-58 192.7 In-house 6-246 (249) alignment 
Range on Protein: 784-1017
Range on HMM: 6-246/249.0
GRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANS
..   |..|||| . ||. ..||.| .    ...|||||| ..|  |  .|  || ||| ||.||| .. ... ...|||..  ..  . ||||||. .|
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

VQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKM-NEFSILVHCLSGAGRTGVFCTAMECI
...| ..| .||. . .|.|.|.|..|.   ..|.||...|...|| ||  |     .|...|.||..  ..  ..  .||||  | ||||.|..|  ..
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvpps..fedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 |. .   ||....|| ||  |.. ||..| | |.|....|.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN14_pd Subfamily PTPN14 491-729 3.4e-58 192.0 In-house 42-294 (300) alignment 
Range on Protein: 491-729
Range on HMM: 42-294/300.0
TVAQEEINFTKNRYKNILPYDSARVKLEVIDNNpHSDYFNASYIPS--FDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
..|. . |  |||.|..|||. .||.|    .| ...| ||| |      ... ||..||| .    |||.|||...|. |.|.|. .|. | |. ||.|
staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

KI--PGDSVKFGNIKVE--LVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF---------THPLIIHCSAGV
|     ..|.||. ||   ...   ..  .. |.  .   ..|||  . .|.|||.|||.  .. |....||..   ..           |...||||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

GRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|||||.|  | ..|  .. . .|. . .. .|..| ..|||  || |.| ....
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPRN_pd Subfamily PTPRN 490-730 2e-57 189.2 In-house 48-291 (297) alignment 
Range on Protein: 490-730
Range on HMM: 48-291/297.0
QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
..||..| | .|||.|..|||| .||||.   .. .||| ||| |   |    ||||.||| ...  |||.|||.. |. | ..|.|.| .  .| .|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

KIpGDSVkFGNIKVELVSLEA-CTGGIKRKM--TMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISID
.  | .| ..  .|.|||    |   . | .    .. .. ||||||||  ||..|||  . |||.| . |   .   . |...|||.|.||||| | ||
de.Gsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SVVAH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 |... .|  . .|.   .  .|..|| .|.|..|. |...|| |.
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0042113 (Phosphotyrosine protein) phosphatases II 785-1017 5.3e-57 188.4 In-house 5-243 (245) alignment 
Range on Protein: 785-1017
Range on HMM: 5-243/245.0
RTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANSV
.   |..|||| . ||. ..||.| ...    .|||||| ..|     .|  || ||| || ||| .. ... .|.|||..   ...  ||||||. .|.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

QFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSStnkMNEFSILVHCLSGAGRTGVFCTAMECIA
..| ..| .||. ...|.|.|.|.||.  .. |..|..|....|| ||  .      ......| . ..    ..  .||||  | ||||.|..|  .. 
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmle

QIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|. .   |.....|| ||  |.. |||.. | |.|....|.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRG_pd Subfamily PTPRG 738-1023 7.9e-57 187.7 In-house 1-293 (563) alignment 
Range on Protein: 738-1023
Range on HMM: 1-293/563.0
IPVVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPDPPAsHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-PD----HDYINASQMKGIH--CTFMT
.|| .|. |. .||..|| .    ...||. |.| . .    .. . . ..|. |||| | .. .| || | . |.    .|||||. ..| .    |..
vpvkefakhvaslhadgdig....fseefealqsetiskdl.daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDANSVQFGSYSVS-----TLSTSSDGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPK
|| ||..|. ||| .. . . ...||. . . .. . | .|||  .|...|. .|      .|....   ..|..||. ....  | ..|.||..  || 
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGSdPQlgaRSLMKLIRAVKSSTNKMNE-FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||. |.    ||..|| ..|||. ...|   |.||| .|.||||...     . || . ..|..|...| .|| |   |||||.| |..|.. | . ...
hgv.Pe...hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

YE
 |
te
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 737-1019 1.1e-56 186.9 In-house 1-285 (290) alignment 
Range on Protein: 737-1019
Range on HMM: 1-285/290.0
LIPVVHFTDHLQdlhsSGDGRGRSKMTKEFQTLKSLCPDppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPD--HDYINASQMKGI--HCTF
|||| .|.....     |  .|.... ..|..|.|   .     .  | | .|...||. | .. . ||..|      .|  ..||||. .||   .  .
lipvdkfgefva....nghakgnegfrnqfkmldsgese...htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy

MTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPKHGS
. || |.. |. |||.|. . | . .||| . .... . | |||||... ..| .|.  |. ..  ....|.|.|. ...  ....|||||.  |...|.
iatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgk

DPQLgARSLMKLIRAVKsSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ..  . .|. . . .|    |  . ||.|||  . ||..|||.|.  | .      .|.|| .| .|  ... |||...| ...... .||..
vtnp.qtillvieemyk.tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_CG7180_pd Subfamily CG7180 468-732 1.9e-56 185.9 In-house 12-291 (296) alignment 
Range on Protein: 468-732
Range on HMM: 12-291/296.0
KNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVT
.... ...  |..  |  .|     . .. |  |||. ...||| .|| || .| . .||| ||.|. ||  .|.||  ..| . . |.|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIAMVTKLKEGDKiKCGKYWPKIPgdSVKFGNIKVELVSLEACTGGIKRKMTMIKG------------DDYRTVTQFHFTEWPD-KGVPKHTSSLLKFIK
.. ..||  .  | .. .|||.      ..|.| ||.|. .  .   .|.. . |              . |.|..|..|||.  . ||  |..|.....
avvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

EVKADHGQF-----THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
 |.   ..      . |.....| |..|.|| ..||  .  .. .  ||||..|  .|..|| .|.. |.| .||  .|| .|
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPRA_pd Subfamily PTPRA 779-1018 4e-56 185.3 In-house 48-297 (330) alignment 
Range on Protein: 779-1018
Range on HMM: 48-297/330.0
SHTRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYW
.        .|. |||. | || . .||||      .. |||||| ..| .   .|...| |.  || ||| .. ..| .|.||| . | .... |||||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PDANSVQFGSYSVSTLSTSSDGDMTIRQLKVT-----RNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEfSILVHCLSGAGRTGV
||  .| .|   |.   .    |.|.|.. |.     .. |.|  |.|. |..||. |  |   .. ..||...||.  ... . .| ||| .|.|||| 
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv.Pf.epiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGt

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY-LH
|..    ....     ||.|..|| ||. | | |||.| | |.| |..|| |.
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_PTPN6_pd Subfamily PTPN6 743-1021 1.2e-55 183.7 In-house 9-301 (306) alignment 
Range on Protein: 743-1021
Range on HMM: 9-301/306.0
FTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPAShTRSGRTRDNHPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMK----GIHCTFMTTQMPL
  .. ..|. ...  ... ...||..|.        |  . |.  .|. |||| | ||   .||||   . |..|||||...|    | ......||  |
ieqrvselekeeeslekagfeeefeelqqeeakklls.rkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl

PTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVT--RNSKTSHTVTQYQFHGWPKHGSDPQLGA
.|||||||..|.. .   .||.  .     . ||.||||...  ..|..||...| .|  | ..|.|.|.  ...|....| ||.|. || ||   . ||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpga

R-SLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQI---AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
  .... ... ......... .|.||| .| |||| |      . .|        .|| ..||..|. | ..||||. | ||| .|..|..|..
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPN1_pd Subfamily PTPN1 487-730 1.3e-55 183.1 In-house 21-270 (290) alignment 
Range on Protein: 487-730
Range on HMM: 21-270/290.0
IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNnphsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKY
 .|...|... | ..|||... ||| .|.|||  ||    || ||| .   . .. || .|||    .| ||.|||...  .. |. |. | ..||| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPKIPG-DSVKFG--NIKVELVSLEACTGGIKRKMTM--IKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhGQF---THPLIIHCSAGVGRT
||.    .....   ..||.|.| |     . |.. .  .| .. |....||.| ||| |||.  ...|||. .|.   | .     | .||||||.||.
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGpavihcsaGiGrs

GVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
| .. .|..... . .     ||. . . ..|. |  ..||..|  | | |.|| 
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 746-1021 1.6e-55 183.1 In-house 6-282 (287) alignment 
Range on Protein: 746-1021
Range on HMM: 6-282/287.0
HLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPpASHTRsGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFW
.. ..  .|  .|.   .. |..|...  ..  . |  . . .|..|||. . |. . .||.|   ..|||||. ..| .    |. .. |.  |. .||
kfgefvakghakgnegfknqftvleqvtqre.devth.niasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

SLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQLgARSLMKLIRA
 |. . .....||| .. .| .. | ||||. .|| .| |... |.     ....|.|.|....|.   ..|.|||.  |...|  ..  . .|. . . 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieem

VKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.|.   |  . ||.|||  . ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| |..|.. |||.. .
yktq.rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 909-1021 1.7e-55 183.1 In-house 171-280 (515) alignment 
Range on Protein: 909-1021
Range on HMM: 171-280/515.0
SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.||||..|..||..|....  ..||.|||..||....... .....||..|.|||||........|.......||.|..|...|..|...|||.|.|||
srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

VYDVIREYLHTEN
.|....|.|.  |
iygavledllwrn
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 469-730 3.1e-55 182.0 In-house 11-292 (301) alignment 
Range on Protein: 469-730
Range on HMM: 11-292/301.0
NRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDN--NPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENV
. |.  |.|....|   .  . ||  .| | . ||.||| .||  |. |.   |    . .| ||||| .. . |..||.||| .    ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLE-----------------ACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSL
..| |||.|||| | || .|||.   .| .||...|.||.                   .  | |.||. . .  . ..|.|.. |.||. || .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFIKEVK-ADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
|. | .|  . .     |...|||..|.|.|| .|..  .  .|    ||||. .  .|...| .|.| ||| .|| .. . 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 772-1021 3.3e-55 182.5 In-house 32-292 (325) alignment 
Range on Protein: 772-1021
Range on HMM: 32-292/325.0
LCPDPPASHTRSGrTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK
| .| . ... ..   .|  |||. | ..|...||.|    |.|. |||||| ..      .|...|.||..|. |.| |||... | ||.||   ....
lpsddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkd

SCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT-SHTVTQYQFHGWPKHGSDPQLG-ARSLMKLIRAVKSS--TNKMNEFSILVHCLS
.||.|||.   .|..||.  |.  .     |   |.|.| . .|  . .| |.|. .|.  | . .     |...|. ||.    .|      ||||| .
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
| |||||| .    .|.. |  .||||. || ||.|| . |.| ..| ..|. . |.. . |
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
0037934 (Phosphotyrosine protein) phosphatases II 787-1017 7.5e-55 181.5 In-house 8-242 (243) alignment 
Range on Protein: 787-1017
Range on HMM: 8-242/243.0
RDNHPKNRYGNNLPLQRNRVILdsPDHDYINASQMKGIHcTFMTTQMPLPTTVSD----FWSLVLNYKPSTVVMLNDKS-QNDKSCAQYWPdaNSVQFGS
  |..|||| . ||. ..||.|  ...|||||. ...   ..  ||.||| || |    || .. ... ...|||..    . . ||||||  ..|..| 
penlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygd

YSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSST----NKMNEFSILVHCLSGAGRTGVFCTAMECI
..| .||... .|.|.| |....   .. ...|..|....|| ||  .      .... .|.. ...    .  ..  .||||  | ||||....|  ..
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

AQIaegdSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYL
 ..    .||....|| ||. |..  |||.. | |.|....|.|
lll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 758-1019 1.2e-54 180.2 In-house 6-279 (290) alignment 
Range on Protein: 758-1019
Range on HMM: 6-279/290.0
GRSKMTKEFQTLKSLCPDPPASH---TRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLN
|. ...||||.||.|     |..   | .|..  |  |||| . || . .|| |     ... |||||. .||   ..... .| |||.|..||| .. .
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

YKPSTVVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSS-DGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSS
.. . |||.  .  ..|  |..|||.   ....||...|.. .    | |..||.|||... |.|..|.|.... || ||  |. .| ||..||..|.. 
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgv.Ps.saksllelielvrel

TNkMNEFSILVHCLSGAGRTGVFCTA---MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 .  ..  ..||| .| ||||. ..     | . .    ...|.|. |  || .|   |||.| | .||  . |....
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Ptp69D_pd Subfamily Ptp69D 762-1021 2.3e-54 179.6 In-house 24-290 (307) alignment 
Range on Protein: 762-1021
Range on HMM: 24-290/307.0
MTKEFQTLKSLcpdPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVV
..||...|..         |. .   .|  |||| .  .  ..||.|       | |||||| .||   . .|.. | |. .|. ||| .. . .  ..|
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSK------TSHTVTQYQFHGWPkHGSDPQLgARSLMKLIRAVKSsTNKM
|| . .. ..  ||.|||. . ||.|.  | . |... .| .||.|.|... .       |. |.||.. ||.     |.  ||.|.|||. |..  .|.
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPev.argllklieqvre.lykl

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
|.  |.|||  |.||.|.| .    . |. . |.||||.||| || .|  .||  | | |.|  . .| .  .
nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_PTPN23_pd Subfamily PTPN23 757-1019 7.5e-51 167.6 In-house 12-282 (288) alignment 
Range on Protein: 757-1019
Range on HMM: 12-282/288.0
RGRSKMTKEFQTLKSLCPDPpASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSLVLNYKPST
 |.... |.|. |..      | ..     . .  |||. . ||  .||| |..   |||||| .|..     .|..|| ||..|..|||..| . | |.
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

VVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKS---STN
.||| .|.. .| ....||| .  ..|.|| .||.  |. . . .  |.||.. . ... ..|.  |.. ||..|  |.    .|.... .|.|   ...
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGv.Pa.sPetllqfldevesayeavq

KMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.  .  ..|||..| ||||||.  .  .... .|. . || | |. ||..|   ||..|.. |.|... |. . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 783-1015 8.6e-51 167.7 In-house 43-277 (315) alignment 
Range on Protein: 783-1015
Range on HMM: 43-277/315.0
SGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDKSCAQ-YWPDAn
  .   |. |||| | ..  . || |      |. ||.||. ..|      ....| |....| ||| || ... ...|||..  ...|. |. ||||  
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSdpQLGARSLMKLIRAVKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIA
 | .| ..|.  |     ..|.| | |. ...  ..| |...  ||. |      . .||.||| ||   .. .  .|.||| .| |||| |.|    . 
kviyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqh.htnsvgaivvhcsaGvGrtGtfitldavld

QIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|.   . .|... .. .|. |.. ||. |.| |.||.. |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 493-728 1.5e-50 166.6 In-house 33-274 (287) alignment 
Range on Protein: 493-728
Range on HMM: 33-274/287.0
AQEEINFTKNRYKNILPYDSARVKLeVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpG
|.|  .  |||| ..||.| .|| | . . .  ||| || |..|. .|.|.||.|||  |.  ||||.|...........|.  |  . || ||||.   
aeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.e

DSVKFGNIKVELVSLEACTGG-IKRKMT--MIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV-----KADHGQFTHPLIIHCSAGVGRTGVVISI
  .. |   | |.. .        | .    ... . | | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|.....
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  .|   . .  ||| . |  .|..|  .||.  |. ..| |. 
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 777-1015 1.6e-49 163.3 In-house 21-264 (283) alignment 
Range on Protein: 777-1015
Range on HMM: 21-264/283.0
PASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK-----GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKS-QNDKSCAQY
|  ..    ...|..|||. . .| ...|| |.|  .|||||. .           .. .| ||  || ||| .| . | ...|||     .... |.||
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLiRAVKSSTNKMNEFSILVHCLSGAGRTGVFC
||   |...| . |.     .   ..|..| .  |  .|..  .. ||. .| . | .. .   ||.|.   |.|  .. ..  |.||| .| |||.||.
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaii..nslvkf.nkvislqteskkgPivvhCstgiGrtavfi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
.|.  . ..     ||.|..|||.| .||  ||| . | .|.... |
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 761-1018 2.1e-49 163.5 In-house 35-293 (319) alignment 
Range on Protein: 761-1018
Range on HMM: 35-293/319.0
KMTKEFQTLKSLCPdpPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTV
|.  ||. .  | .  . .        .|  |||..| |.  .|.| |.  .     |||||| ..|      ....| ||. |. ||| .. .|. ||.
klevefrracklgv..nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLNdksqnDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNKMNE-F
|.|       . |.||||    .. . . |.  |     . ..|.......   |    .||. | |||..|  |. ..  ||.|.. |.  |.|.|.  
vllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGv.pdyps.dlmrlvkkvrhltskenhra

SILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
.|.||| .|.|||||. .    . .. | . ||....|. || .| ..||   .| |.|  . | .| 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 761-1019 4.5e-49 162.1 In-house 16-278 (281) alignment 
Range on Protein: 761-1019
Range on HMM: 16-278/281.0
KMTKEFQTLKSLCPDPPASHTrsgRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTV
 ...|...|...  | .|. .   .. .|  |||| |       || .    .. . |||||. ..|..    ...|| |.|... .|| .|...| |..
Gfieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLNDKSQNDK-SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEFS
||.  . ...|  | .|||| | ....| . |.......   .  |..|..|.|  . .|.| ..  || ||  |.  .. |..  ..|.. |.| .. .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGv.Pa.ttkellefrkevlkltekktkap

ILVHCLSGAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
...|| .| ||||.. .    . ... |  ..|. ..|. || .|. .|||   |.||| .. ..|. 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN9_pd Subfamily PTPN9 748-1017 1.1e-48 160.8 In-house 4-290 (297) alignment 
Range on Protein: 748-1017
Range on HMM: 4-290/297.0
QDLHSSGDGRGRSKMTKEFQTLKSlcpDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGI--HCTFMTTQMPLPTTVSD
..| .    .|.. ..||.. ...    |..      ..| |  |||| . | ... || | .       |||||. . |   . .|..|| ||. ||||
eelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWSLVLNYKPSTVVMLNDKSQND-KSCAQYWP--DANSVQFGSYSVSTLSTSSDGDMTIRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKL
|| .| . .  ..||     ..    |.||||  . .| .||..|||.... .  | ..|.|...  . . | .|| .|| .|| .|  |.  | ||...
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGv.Ps.saaslldv

IRAVKS------------STNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
...|..            .. ....  |.||| .| |||| |.|   |.... | . ||...||| ||. |   .||.| |.| |  . || 
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 785-1018 1.3e-48 160.9 In-house 21-257 (284) alignment 
Range on Protein: 785-1018
Range on HMM: 21-257/284.0
RTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNdksqnDKSCAQYWPDANSVQ
   .|  |||.|. |.  .|.| |.  .     |||||| ..|      ...|| ||. |. ||| .. .|. ||.|.|      .. |.||||    ..
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivik

FGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNKMNE-FSILVHCLSGAGRTGVFCTAMECIA
 . . |.  | .   ....|.......   |   ...|. | |||..|  |. ..  ||.|.. |.  |.|.|.  .|.||| .|.|||||. .    . 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgv.pdyps.dlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

QIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
.. | . ||....|. || .| ..||   .| |.|  . | .| 
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_CG7180_pd Subfamily CG7180 759-1018 4.8e-48 158.3 In-house 12-291 (296) alignment 
Range on Protein: 759-1018
Range on HMM: 12-291/296.0
RSKMTKEFQTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPS
| |.  |.. .  | |     . . |   .|  |||. . .|   |||.|..     . |||||. . .      .. |..|   || .||.|| . . |
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TVVMLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-----------SKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAV
.||.| .. .  | . .|||     |.|   | .... .  ...||..|.|..           .    .|...|.  |. . . |   . .|..|.| |
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPls.tnalielrrrv

KSSTNKM----NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
..  .|.    .|  ..|..  ||.|.||....  .. .. . . ||.|. || || .| | |.. ||| ..|||. |.. 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
0051429 (Phosphotyrosine protein) phosphatases II 524-730 2e-47 157.4 In-house 2-224 (272) alignment 
Range on Protein: 524-730
Range on HMM: 2-224/272.0
PHSDYFNASYIPSFDN---DKAYIASQGPNNASTDDFWRMvWQENVTTIAMVTKLKEGDKIKCGKYWP----------KIPGDSVKFGNIKVELVSLEAC
| |.|.||.... . .   ......|.|| ... .||||. ......|| ..... | .. || .|||               .. .|.. | |.| | .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TGGIKRKMTMI---KGDDYRTVTQFHFTEWPDKGVPKHTssLLKFIKEVKAdhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVD--------V
.  | |.....   . ...|.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ...    . .||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
...|  .|..||..|||.|||.|.| |.|| 
eeaveelraqrpgavqteeqylflyeallel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 777-1018 2.4e-47 156.3 In-house 15-269 (274) alignment 
Range on Protein: 777-1018
Range on HMM: 15-269/274.0
PASH-TRSGRTRDNHPKNRYGNNLPLQRNRVIL-----DSPDHDYINASQMKGIH---CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKS
|. . ..  .   .. |||| . || .. ||.|     ...| .||||  .|| .    ... || |||.||.||| .. . . . .||| . | .| . 
PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk

CAQYWPDANSV----QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKtSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNEF--SILVHCLSG
||.|.|||...    ..|  .. . .. .  | ..|.| .   .. ...|. | .  || | |  .  |..|..|.. |..| .. |.   ...||| .|
CavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
 ||||.| ..  .. |. |   ||....|  || ||   |||.| | ... .. .||.
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 777-1014 1.1e-45 150.7 In-house 29-272 (280) alignment 
Range on Protein: 777-1014
Range on HMM: 29-272/280.0
PASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK------GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQ
|  ..   |  .| .|||| . ||    ||.|.. . |||||. ..      |.   ...|| ||..|..||| .| . | |..||| .  .. .  | |
pglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEfSILVHCLSGAGRTGVF
|||.  .....|..||   .....  . .|.| ..... | .....| |.  || ||  |.  . ....... |..  . ..|  ..||| .| |||||.
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgv.Pd.dsadflefvervrklrsgkee.PvvvhCsaGigrtGvl

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
 .   ..| | . ..| . . |. .|  |. .|||.. | || . | 
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0041856 (Phosphotyrosine protein) phosphatases II 498-739 1.7e-45 150.2 In-house 1-179 (182) alignment 
Range on Protein: 498-739
Range on HMM: 1-179/182.0
NFTKNRYKNILPYDSARvklevidnnpHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTklkegdkikCGKYWPKIPgdsvkf
|..||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|         .  |||.        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gnikvelvsleactggikrkmtmikgddYRTVTQFHFTEWPDKGVPKhTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrMV
                            .|...|.... ||| |||  ...||.||.||..      .| ..||||||||||... .. .  .      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIP
.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_PTPN13_pd Subfamily PTPN13 763-1018 5.2e-45 148.8 In-house 14-270 (273) alignment 
Range on Protein: 763-1018
Range on HMM: 14-270/273.0
TKEFQTLKSLCPdppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHdYINASQMKGI----HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLN
..||..|. | |     ....|....|. |||| | || .. ||.|..    ||||| .|      . ... .| |||.||.||| .| . | . ..|. 
aeefkelrelkp...ldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

-DKSQNDKSCAQYWPDANSVQFGS---YSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmNEFSI
 .| ..   | .|||. .. .      . |. | .    ....|.|.|.  .|. |. |.. .|  || ||   .  | .|..... |..  .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPi

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
.||| .| ||.|.. |    .  |.   ..|. ..|. ||  |   |||.. | ||| .| | |.
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 475-728 4.5e-44 145.2 In-house 13-266 (281) alignment 
Range on Protein: 475-728
Range on HMM: 13-266/281.0
FSEEFHDLPG-PNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEV-IDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMV
| .|| .||| |     || .. .|  |||| ||   | .||.|.| . |.  .||  | || |    . || .|||.. .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCS
 .. | .. || .|.|.     ..| .. |.          .  .. .    . | .|.. . ||||  ||. .  .|| .....|     . | .||||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRTGVVISIDSVVAHAKT-TRMVDVFNFVTNIRQ-KRPYMVQTQEQYAFIYGAVL
|||||.| .....  .   ..   . |. . |. .|   |   ||| .|| .|.  .|
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 789-1020 5.1e-44 145.3 In-house 20-267 (270) alignment 
Range on Protein: 789-1020
Range on HMM: 20-267/270.0
NHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG---IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDANSV---
..  ||| . ||  . ||.|..    .   ||||  ..|    ........ |||||...|| .... | ...||. . . .. | |..|||  .     
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSDPQLG----ARSLMKLIRAVKSSTNKMNEF-SILVHCLSGAGRTGVFCTAM
 ..|  .| .||.. .    ...|........ . .. .... || ||  .. .    ...|.|..|||. |......   .||||  | ||||.. .  
ledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 ..  . |  .||. . .. || |||..||. |.|.|.| ...|| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0036282 (Phosphotyrosine protein) phosphatases II 526-724 1.1e-43 144.3 In-house 2-163 (174) alignment 
Range on Protein: 526-724
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNDKAYIASQGPNNastddFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKipgdsvkfgnikvelvsleactggikrkmtmIKGDD
|||.|||..  .   . .||.||| .     ||.|......||. |....|| .. ||  |||                                 . | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

YRTVTQFHFTEWPDKGVPKHTSsLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKtTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.|.. |.... ||| |||  .  ||.|.|.|.  . .   .|...||||||||||... .. .  . . ...||....|  .|..||.||||..|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 477-732 2.1e-43 143.5 In-house 20-278 (307) alignment 
Range on Protein: 477-732
Range on HMM: 20-278/307.0
EEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVidNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLK
.||. |   .    ||   . |  ||||...   | .|. ...  .   |||  | |.    . | .|..||| ...  .|| |. ||.| .. |. |. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EGDKIKCGKYWPKIPGDSVKFGNIKV--ELVSLEACTGG-----IK-RKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLI
|  |||| .|||   |.   ||.      .  | | .       |.  .. .  ... ||.... ...|||.|||.   . . ... |. |    | |..
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvv

IHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
.||||||||.| ...|  |     .     |. ..| ..|..|.| .||. || ...  .|| .|
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_PTPN14_pd Subfamily PTPN14 779-1018 7e-43 141.7 In-house 39-297 (300) alignment 
Range on Protein: 779-1018
Range on HMM: 39-297/300.0
SHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP---DHDYINASQMK----GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQY
... ...  .| .|||. . || . ||| | .    ...|||||..|    | . .....| ||..|| ||| .| . . . .||| .. .. |  . .|
allstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDA----NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQL-GARSLMKLIRAVKSSTNKMNE-----FSILVHCLS
.|.     ..|.|| . |.|  ... . .. ..||.    ||   ||   |.  ||.||  . . |  | .. ...|.  ||...|       .||||. 
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
|.|||||  ..   || .  ....|| .....||  || .|||   | |||.|. .||.
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 762-1021 1.1e-42 140.7 In-house 17-297 (301) alignment 
Range on Protein: 762-1021
Range on HMM: 17-297/301.0
MTKEFQTLKSLCPDPpashTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP------DHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPST
. .....||.  ...    .  | . .|.. ||. |. ... ||.||          ..||||| ..|.     |. .| |.  |. ||| |....||..
feeqykelkegedks....ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

VVMLNDKSQN-DKSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLKVT----------------RNSKTSHTVTQYQFHGWPKHGSDPQlgARSL
.||. .. ..  ..| ||||...    .||  .|   ..    |..||||.|.                ...|.|..|.|.|   ||..|  ..   |  
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre..prtv

MKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.. |  |   ..|..   ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | ..|||| .||. ..
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 495-732 1.8e-39 130.2 In-house 52-290 (305) alignment 
Range on Protein: 495-732
Range on HMM: 52-290/305.0
EEINFTKNRYKNILPYDSARVKLeviDNNPHSDYFNASYIPS-FDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGD
 .|. |||||...   | . |||   |. . |||  | |.   .  .| .|..||| . . |.|| || |..|  | |. |  |  |.|| .|||   |.
adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

SVKF-GNIKVELVSLEAC-TGGIKRKMTMI----KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSV
 ... . | || ||         . ..|..     ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyi

VAH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
. . |.  .   . ..|  .|..| . .|.. || ||.  .|. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 491-728 2.2e-39 129.9 In-house 49-280 (290) alignment 
Range on Protein: 491-728
Range on HMM: 49-280/290.0
TVAQEEINFTKNRYKNILPYDSARVKLEvidNNPHSDYFNASYIPSFdnDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKI
 . ... .|.|||||..   | .|| |.   .  . ||  | |.     .  .| .||. .... |.|||| ||.|..| |. .| |  | || .|.|. 
kifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

PGDSVKFGNIKVELVSLEACTGGIKRKMTMIK-GDD--YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSV
 |. . ||.| |     .     |..|.  ..  |.     .  ..   |||| |.. | .||. .. ..   |    |...|||||.||||  ..|.  
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievg

VAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.      . .|. . |  .|. |   || . ||  .  ..|
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
0043147 (Phosphotyrosine protein) phosphatases II 523-724 6.1e-39 128.8 In-house 2-154 (172) alignment 
Range on Protein: 523-724
Range on HMM: 2-154/172.0
NPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLkegdkikcgkywpkipgdsvkfgnikvelvsleactggikrkmTMIK
...||| ||||..     . .|| ||| .  ..|||||......|.| ..|.|                                           . ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

GDDYRTVTQFHFTEWPDKGVPkHTSSLLKFIKEVKA-DHGQFTHPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPYMVQTQEQYA
 . .|.. |.... ||| ||| ... ||.|.. ..   . .  .| ..||||||||||... .. .       . ..... |  .|.|||..||...|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIY
|.|
fly
subfamily_PTPN1_pd Subfamily PTPN1 780-1015 6.1e-39 128.5 In-house 23-269 (290) alignment 
Range on Protein: 780-1015
Range on HMM: 23-269/290.0
HTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINAS--QMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDA--
.||. ..  |...||| .  | .  |..|.. | ||||||  ... ..  .. || ||| ||. || .| . |  .|||||   . .   ||||||    
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-NSVQFG--SYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSdPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTA
 .....   ...|  .|. .    |.|.|...  ... ....... .  ||  |  |.  |  |  | .  .| . . .    ..|| .| ||.| || .
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgv.pespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

MECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  |...| . |    ||| ...  ||  |. ..|| .   | |  | |
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 497-729 6.7e-39 128.4 In-house 47-285 (305) alignment 
Range on Protein: 497-729
Range on HMM: 47-285/305.0
INFTKNRYKNILPYDSARVKLEviDNNPHsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVK
 .  |||||..   |  |||||     || .|  | |. .  | | .| .| | . .  ||| | .|..| .| |. .|.|    || .|..   .| ..
qeagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FGN----IKVELVS-----LE-ACTGGIKRKMTMIK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISI
| .    | | . |     ..  .   ... . .|.  | . | ||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |. .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvml

DSVVAHAKTTRMVDV-FNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. ..    . ....     .  ||..|   .||..|| |..  .|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_PTPRN_pd Subfamily PTPRN 758-1015 1.8e-38 126.9 In-house 27-290 (297) alignment 
Range on Protein: 758-1015
Range on HMM: 27-290/297.0
GRSKMTKEFQTLKSLCPDPPASHtrSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSLVLNYK
 .... ||...|..   .| ...   ... .|  |||. . || . .|| |..     ..||||||..      . ....|| ||..||.||| .| .  
nkdrlekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

PSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSD-GDMTIRQ--LKVTRNSKTsHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTN
   .|.|   ...  | |..||||  |  .. | |  .|      |  .|   ||  ..|.|  ||||. |  ||..|  ..  |.||... | |  |  
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPas..aksllefrrkvnksyr

KmNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
     .|.||| .|||||||..     ..... |   .||  |.. || .| ..|.|.... |.. .. |
G.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 760-1020 6.5e-38 125.1 In-house 10-280 (287) alignment 
Range on Protein: 760-1020
Range on HMM: 10-280/287.0
SKMTKEFQTLKSLCPDPPASHtRSGRTRDNHPKNRYGNNLPLQRNRVILD-SPDH--DYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTV
 .. ||...||      .|   ..     .  ||||.. ||.  .||.|   ...  |||||  . . .   .|...| |...|| ||| .||. . ..|
ddvdkevdalkedsesstatf.kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv

VML-NDKSQNDKSCAQYWPDAN-SVQFGSYSVSTLST-SSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQ-LG-ARSLMKLIRAVKSSTNKM
...  .  .  . | .|||. .  .. | |||  |.    . . ..| |..     . .. | |...  ||...  |  .| .|  ..  . .. . .  
itmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
.   ..||.  |.||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|. .  | .|.
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 788-1014 8.3e-38 124.9 In-house 2-236 (237) alignment 
Range on Protein: 788-1014
Range on HMM: 2-236/237.0
DNHPKNRYGNNLPLQRNRVILDSP--DHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDK-SQNDKSCAQYWPDANS-VQFG
.|. ||||||    . .||.|  .  . |||||. .||.     .....| || ..  ||| .| . | | .|||     .|.. | .|||...    .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVSTLSTSSDGDMTIRQLKVTRNS--KTSHTVTQYQFHGWPKHGSdPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIA
 ..||        | |.| | ....   |    . ||||  ||..|  ||  |  |    . .. |    .    ..|| .| ||||.|      . |  
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgv.pqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
|   |||.. |. .  ||   .||...| |....| 
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 496-655 9.9e-38 124.7 In-house 31-192 (297) alignment 
Range on Protein: 496-655
Range on HMM: 31-192/297.0
EINFTKNRYKNILPYDSARVKLEviDNNPHSDYFNASYI--PSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGD
.  . ||||..|| .|..||||      . .|| || |.  |  ..|  || .||| .|. ||||..|....| .|.||.||.|. . ||  |||.. ..
nsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

SVKFGNIKVELVSLEAC--TGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKE
  | |.. || .|  .      |  ....|  .. | |.   |  |||.|||     | .|  .
rlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
0049772 (Phosphotyrosine protein) phosphatases II 490-733 2.8e-37 124.5 In-house 38-282 (314) alignment 
Range on Protein: 490-733
Range on HMM: 38-282/314.0
QTVAQEEINFTKNRYKNILPYDsARVKLEVIDNNPhSDYFNASYIPSFdndKAYIASQGPNNASTDDF----------WRMV--WQENVTTIAM------
 .||. . | .||||..|||.|  ||.|   ...  |||.||||. .|   ...||.|||..   .||          ||||  .. || .| |      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------VTKLKEGDkikcgkywpKIPgDSV-----KfgnikvelvsleactggikrK-------MtmikgddYRTVTQFHFTEWPDKGVP-
                ..| ..           .| .       |                    .                |.. ... . .|| ..| 
adelsrLdaAlgKtpllildgng.........nep.taadlellk....................eelydpelf.......erlgikylripvpDgsapl

-KHTSSLLKFIKEVkadhgQFTHPLIIHCSAGVGRTG--VVISIdsVVAHAkttRMvDVFNFVTNIRQKRP-----YMVQTQEQYAFIYGAVLEDLLW
 ..  ..|.||.|.     .  .|...||.||.||||  ||. .  .. .    .. ..   .  .|.|||      .....||| ||. |.|| | .
ledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
0051429 (Phosphotyrosine protein) phosphatases II 813-1019 4.5e-37 123.5 In-house 4-227 (272) alignment 
Range on Protein: 813-1019
Range on HMM: 4-227/272.0
HDYINASQMKGIhCT------FMTTQMPLPTTVSDFWSLvLNYKPSTVVMLNDKSQND-KSCAQYWP------------DANSVQFGSYSVSTLSTSSDG
 .||||. ..|  .       .  ...||| |. ||| |  ... .|.|.| . .  .   | .|||            .| .. .| ..| .||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAvksstnkmnEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVD-------
|...| | .|.    .....|.......|| ||  ..   ..|..|...         .  .|||| .| .|||... .  ..... . . ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ....|. ||| |...||||| |.|.|....|.| .
yleeaveelraqrpgavqteeqylflyeallellrs
0049260 (Phosphotyrosine protein) phosphatases II 534-724 4.9e-37 122.3 In-house 2-143 (152) alignment 
Range on Protein: 534-724
Range on HMM: 2-143/152.0
IPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWpkipgdsvkfgnikvelvsleactggikrkmtmikgddyrtvtQFH
|. . . ...|| ||| . ...|||||... ..||| |.|.| | .|.|| .|.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.. ||| |||...  || ... ..    .  .| ..||||||||||... .. .       . |.....|  .|.|||..|....|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0041856 (Phosphotyrosine protein) phosphatases II 789-1022 5.2e-37 122.6 In-house 1-176 (182) alignment 
Range on Protein: 789-1022
Range on HMM: 1-176/182.0
NHPKNRYGNNLPLQRNRvildspDHDYINASQMKGIHCT--FMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNdksqndksCAQYWPdansvqfgsysvst
|..|||| . ||  ..|      | |||||. . | . .  |  || ||. || ||. .. ... .|.|.|.        . .|||              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..............

lstssdgdmtirqlkvtrnSKTSHTVTQYQFHGWPKHGSDPqlgARSLMKLIRAVKSstnkmNEFSILVHCLSGAGRTGVFCTAMECIAQiaegdSVDIF
                   ..  ....||....|| ||  .    ..| ..|..|..     ..  .||||  | ||||... |  .. .     .|...
...................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

QTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
..|| .|  |.. |.|.. | |......|.|.  ..
eavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 485-734 1.8e-36 120.6 In-house 29-274 (288) alignment 
Range on Protein: 485-734
Range on HMM: 29-274/288.0
PNIYPQTVAQEEI-NFTKNRYKNILPYDSARVKLEvidNNPHSdYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKC
||  .. .... | | |..||.|.   | .||||.   ..|.  | .|  ..|  ...  | .| | |.  . .|.|. ...|  | |...| |  | | 
pneasidiidsfianptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks

GKYWPKIPGDSVKFGNIkVELVSLEActGGIKR--KMTMIK----GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVkadhGQFTHPLIIHCSAGVGR
 .|.|   |.....| .    |  .    .|..  |.....    |..   | . |. ||.|.|||.   | |.... .     ....|...|.||||||
aeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGr

TGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWR
|| .| |  ..  .. .  . . ..... |..|   .||. || ...  |||.|| .
tgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
0046846 (Phosphotyrosine protein) phosphatases II 519-727 2.6e-36 120.4 In-house 5-169 (176) alignment 
Range on Protein: 519-727
Range on HMM: 5-169/176.0
VIDNNPHSDYFNASYIPSFdndkAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVkfgnikvelvsleactggikrkm
..  ....|| ||..| .     ..|| ||| . .. ||..|......|.. ..|...| ...||  ||| . . ..                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tmikgddyrtvtQFHFTEWPDKGVPKHtSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDsvvaHAKTTRMVDVFNFVTNIRQKRP-YMVQTQ
            |.... ||| ||| . . ||.......    .  .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..|||.
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYAFIYGAV
||| |.| ..
eQyrflyefe
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 498-726 3.2e-36 119.7 In-house 33-254 (267) alignment 
Range on Protein: 498-726
Range on HMM: 33-254/267.0
NFTKNRYKNILPYDSARVKLEVIDNNphsdYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEgDKIKcgKYWPKIPGDSVKF
|  .||. . |||| .|| |   ...    | ||||. ..   .|.|. |.| . .  ||. .. ...|..| ..||  . |.|.  ..||   |.. |.
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dnir..lfwPPkmgqakky

GNIKVELvSLEACTG--GIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSS-LLKFIkeVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT
 .. ||  |||       |      .| .  . || ... .|  .   |     |.  .   | .  .  .||...||.||||.|  . ||| .  ||| 
qdltveh.slekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
 ..|.|.|. .||..|. .|.|.|.| .|.  
gvsdifdflrkirsqriglvdtkeryiyihel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 761-1022 2.8e-35 116.4 In-house 28-288 (290) alignment 
Range on Protein: 761-1022
Range on HMM: 28-288/290.0
KMTKEFqtLKSLCPD-PPASHTRSGRTRDN-HPKNRYGNNLPLQRNRVIL-DSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVML
...||.  |. | |  |     |.   ..    |||| .    .. |||| |  | ||. |  .||.. .|. || .|  || |.| .||. | ...|||
elakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivml

NDKSQNDKS-CAQYWPDAN--SVQFGSYSV-STLSTSSDGDMTIRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdpqlgARSLMKLIRAVKSsTNKMNEfS
 .  .. |. |.||.|. .   . ||...|  ..... | ..  . | |  ..|  .| .  ..   || .       | | . |.| ...   |..   
celiedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtlri.lrkasG.p

ILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
. ||| .| |||| | .   ..  . .| ..|. ..|. ||  |.. || . .|  . ... ..    .|
vvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_ptpA1_pd Subfamily ptpA1 495-683 3.9e-35 116.4 In-house 44-248 (418) alignment 
Range on Protein: 495-683
Range on HMM: 44-248/418.0
EEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSfDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPK-IPGD
.. | .|||| |||| . .||.|. |...  ||| || ||      | .|..|||   .  |||||||.. .  | |...  |  .||| .|||. | |.
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

SV--------KFGNIKVELVSL--EACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF------THPLIIHCSAGVGR
 .         ||   |||| .  .     | |.. .    . | .||...  |||. .| ||  . .... .   . |         |.|.||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGVVIS
|| . .
tgtfct
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 620-767 4.8e-35 115.7 In-house 82-230 (440) alignment 
Range on Protein: 620-767
Range on HMM: 82-230/440.0
MIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQE
.|.| . ||. |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||.|..||.. .|| .  .|.|.|. ..|..|| |||| |
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
||||.. |||| ||  .|||     |.......       .| . .||.
qyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
0051082 (Phosphotyrosine protein) phosphatases II 524-727 4.9e-34 112.4 In-house 1-149 (151) alignment 
Range on Protein: 524-727
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdndkaYIASQGPnnasTDDFWRMVWQENVTTIAMVTKLKEGDkiKCGKYWPKIPgdsvkfgnikvelvsleactggikrkmtmikg
|.|||.|.||. ..     ...|.||    ..||..........|| ......| .  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ddyRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdhgQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrmVDVFNFVTNIRQKRPYMVQTQEQYAFI
   ..|...... ||| |.| .. ..|.|.... .   .  .|...|||||.||||... .. .  .      |...  .  .|.|||..||. .|. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YGAV
. |.
lfal
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 760-1017 5.2e-34 112.4 In-house 20-279 (439) alignment 
Range on Protein: 760-1017
Range on HMM: 20-279/439.0
SKMTKEFQTLKSLCPDPPASHTRSGRTRDnHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPST
  ....|....|  ||  .  .   .  | ..|||| .  ...  ||.|      |   ||||  .|| .    ...||.|   |. ||| ||.. | .|
eifkeifekinstspdyaciaslaaqeyd.qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

VVMLNDKSQNDKscaqYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS---KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNE
.||| .  .  |    |||  . | .|  .| .       . .|| .||  .    .  .|| |...  ||..    |  |  .....||..|. .| . 
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeey

FSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  ..||| .| ||||   .   .. |.   . |||   ||.|| .| |.||.  .| |.|. . | .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 492-731 1.6e-33 110.9 In-house 29-270 (285) alignment 
Range on Protein: 492-731
Range on HMM: 29-270/285.0
VAQEEINFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYIPSFDND-KAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKI
 .  | |   ||| ..   . .|| |.    |   ||  ||..    .|  .||..|||   .  |||.|..||... . |.  | ||   ||  |.|. 
ytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

PGDSVKFGNIKVELVS--LEACTGGIKRKMTMIKGDDYRTV----TQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQfTHPLIIHCSAGVGRTGVVISI
 |. ||||. .. |     || .| |   .|.|. .|  .      . .   |||.  |. .  .... | ||    .  .|. .|||||||||  .. |
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgi

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
|    .      ..... | ..|  |   ||.. |. |.|  ..| .
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
PTPc_DSPc_SM00012 628-729 2.3e-33 109.9 In-house 1-105 (105) alignment 
Range on Protein: 628-729
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
||...|.|.|||.|||....|.|.....||  . .   ..|...||||||||||... .| .. . ... . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle
0044763 (Phosphotyrosine protein) phosphatases II 509-726 5.6e-33 109.4 In-house 1-166 (178) alignment 
Range on Protein: 509-726
Range on HMM: 1-166/178.0
PYDSARVKLEVIDNNPHSDYFNASYIPSFdndkAYIASQGPnnastDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGdsvkfgnikvelvsle
|.|  ||.|. . . . |||.|||.|  .     |..|..|      |..........|.| ..|. .|. ..|| .|||.  |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

actggikrkmtmikgddyrtvTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttRMvDVFNFVTNIRQ
                      |.... .|| |||  .. .|.|.. ... . .  .| ..||||||||.|... .. .  .    .. .... .  .|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

KRPyMVQTQEQYAFIYGA
.|| .|....|. ..|  
rRp.ivpnpgqlrqLyef
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 760-1017 1.3e-32 107.9 In-house 6-259 (267) alignment 
Range on Protein: 760-1017
Range on HMM: 6-259/267.0
SKMTKEFQTLKSLCPDppASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVML
 .. |||. .| . ..   |      . .|. .||. .||| . .||||   ...||||| ..| .   .|. || ||  |..||. .. ..| ...|.|
ceiekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDkSQNDKsCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDpQLGARSLMKLIrAvKSSTnKMNEFSILV
   .  |.   ..||    .. ..   .|       . |  |  |..  . ...| || | .. |     . .   . |. .. | |    .  .  ..|
tk.vftdn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnn.kpylkplfgil.a.knql.engnrPlvv

HCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|  | ||.| | ..   . .. . . .|||. .. .|  |. .|.| |.| ...... || 
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 774-876 2e-32 107.1 In-house 30-147 (392) alignment 
Range on Protein: 774-876
Range on HMM: 30-147/392.0
PDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-----KSQ
|.|.......... .| .||||.|.||....||.|    |.||.||.|||.......  .....|.| .....|||..|.. ...|..|...     | .
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

NDKSCAQY----WPDANS
.....||.    |||.. 
dartvaqfhftewPdkdv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 500-726 4.8e-32 105.9 In-house 52-277 (301) alignment 
Range on Protein: 500-726
Range on HMM: 52-277/301.0
TKNRYKNIlPYDSaRVKLEVIDNNPHSdYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGN
 |.||... | .     .|||..        | .||.  . . .||.||| .....||| |. | .| .|.|...  |  . || .| |  ...... | 
dkhryptv.PckP.stavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

IKVELVSLEACTGG--IKRKMTMIKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAHAKTT
 |..... |       .||.. .       . |||| . ..||.|.||||    | .... ||  .    .|...|||||.||.   |. . .  . .. 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylarevead

RMVDVFNFVTNIRQKRPYMVQTQEQYAFI-YGA
. ... . . ..|..|   |||..|  ..  |.
ptieltealkhlrehrwngvqtnsqlywmtlGt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 785-1011 2.1e-31 103.9 In-house 4-235 (239) alignment 
Range on Protein: 785-1011
Range on HMM: 4-235/239.0
RTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANS
. | |. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| .. . .   .|||    .   | | |||||. |
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

vQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLGArSLMKLIRAV-KSSTNKMNefSILVHCLSGAGRTGVFCTAMECI
 ..    |.   |    |  || . ...  .|    | ||.|  || .|  ||  . ... | | . | |         ..|| .| |||| |      .
.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgv.pqyat.avlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
 |  .  .||||. || .| || ..||| |.| |.. 
rqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 785-1012 2.1e-31 103.9 In-house 3-235 (239) alignment 
Range on Protein: 785-1012
Range on HMM: 3-235/239.0
RTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANS
. | |. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| .. . .   .|||    .   | | |||||. |
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

vQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLGArSLMKLIRAV-KSSTNKMNefSILVHCLSGAGRTGVFCTAMECI
 ..    |.   |    |  || . ...  .|    | ||.|  || .|  ||  . ... | | . | |         ..|| .| |||| |      .
.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgv.pqyat.avlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 |  .  .||||. || .| || ..||| |.| |..  
rqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 498-724 9.5e-31 101.5 In-house 52-283 (310) alignment 
Range on Protein: 498-724
Range on HMM: 52-283/310.0
NFTKNRYKNILPYDSARVKLEvIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGDSVKF
.. |||| ...  |..||||. ||.  . ||  | |. .    ...| |||| . .  |||||..||   .| .. |  |  . ||  ||| . | .  .
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtety

GNIKVELVS-----LEACTGGIKRKMTMIKGDDYR------TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDS
| |.|  .|     .| |   .      .  |.         |.  .. .|||.|||      .      .  ||    | ..|||||..|..||.... 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalkl

VVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 . ...    ||. . .|.....|   .||. || .| 
kidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_egg_pd Subfamily egg 490-728 4.1e-30 99.5 In-house 32-267 (307) alignment 
Range on Protein: 490-728
Range on HMM: 32-267/307.0
QTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDkiKCGKYWPK
 | | .. | .| | | .   ||.|||||.       |.  | ..        .| .| |   . |||||||.||.|  | |.|  || .  .|  ||||
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpk

IPGDSVKF--GNIKVELVSLEACTGGIKR--KMTMIKGDdyrtVTQFHFTEWpdKGVPKHTSSLLKFIkEVKADHGQFTHPLIIHCSAGVGRTGVVISID
 . ||...  |....| . ..  .  . |  |. .. ||      . .   |  .|  ...| .   . .|     . ..| ....  || .......|.
aesdslvtvpGslrienlkvdskadplfrvtklklvGgd....deerflehw..qgdvnnssdvyspl.rvlrklrnlskpvvvqdilGvskaatlvaie

SVVAHAK--TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  . .     .    | . |  .|..|.. |..  .| |.|  ||
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_ptpA1_pd Subfamily ptpA1 761-973 4.4e-30 99.7 In-house 22-252 (418) alignment 
Range on Protein: 761-973
Range on HMM: 22-252/418.0
KMTKEFQTLKSLC-PdppaSHTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC-TFMTTQMPLPTTVSDFWSLVLNYKPSTV
|. .||. |.    |    | |  |  . |  |||| | ||... || |    |    |||||  . | .   |. || ||| |..||| .| . .   .
kikeefrlleesvgp....setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcrii

VMLNDKSQNDK-SCAQYWPDAN-----------SVQFGSYSVSTLSTSSDGD--MTIRQLKVTRNSKTsHTVTQYQFHGWPKHGS-DPQLGARSLMKLIR
|||. .|.| .  | .|||.                ||.|||  .    | .  .  |....| . .| . .||||. ||| |   |     | |.. | 
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsit

AVKSS--TNKMNEFSILVHCLSGAGRTGVFCTAMEC
  .     .   .  |.||| .| |||| ||||.  
nrqnqiipssdrnvpiivhcsagvgrtgtfctavim
0046846 (Phosphotyrosine protein) phosphatases II 804-1017 5.1e-29 96.7 In-house 3-173 (176) alignment 
Range on Protein: 804-1017
Range on HMM: 3-173/176.0
NRVILDSPDHDYINASQMKGihCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKS-QNDKSCAQYWPDANSVQFgsysvstlstssdgdmtirqlkv
 |.. . .| |||||. . |  . . .|| ||| |. ||. ...... ..||.|..    .  .|..|||.  ....                       
lrllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

trnsktshtvtQYQFHGWPKHGSDPQlgaRSLMKLIRAVKSSTNKMneFSILVHCLSGAGRTGVFCTAMeciaQIAEGDSVDIFQTVKILRADRM-QFVQ
           ||....|| ||  .    . |..|......  ..     .||||  | ||||... |      .  .  ........ .|. |. . ||
...........qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TEEEYAFVYDVIREYL
|.| | |.|......|
tpeQyrflyefellll
0049772 (Phosphotyrosine protein) phosphatases II 782-1018 5.3e-29 97.3 In-house 39-281 (314) alignment 
Range on Protein: 782-1018
Range on HMM: 39-281/314.0
RSGRTRDNHPKNRYGNNLPLQrNRVILDS---PDHDYINASQMKGIhCTFMTTQMPLPTTVSDF----------WSLVL--NYKPSTVVM----------
  ..   |. |||| . ||   |||||..    ..|||||| ..|. ..|. || ||. || ||          |..||   ... ..||          
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LNDKSQNDkscaQYWPDANSVQFGsysvstlstssdgdmtirqlkvTRN---SKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVk
           |.. . |      ... |.  ..                       ..    .. .... .|  . .| .. ..    ......|... 
srLdaAlgKtpllildgng....neptaadlellk......................eelydpelferlgikylripvpDgsaplledfdeflefieea.

sstnkMNEFSILVHCLSGAGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRM-----QFVQTEEEYAFVYDVIREYLH
      ..  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... |.| |......||| 
.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0036282 (Phosphotyrosine protein) phosphatases II 813-1011 5.3e-29 96.5 In-house 2-164 (174) alignment 
Range on Protein: 813-1011
Range on HMM: 2-164/174.0
HDYINASQMKGIHCT--FMTTQMPLPttvsdFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDansvqfgsysvstlstssdgdmtirqlkvtRNSKTS
.|||||| ... ..|  .  .| ||.     || .. ... .|||||..  ...   | .|||.                              . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HTVTQYQFHGWPKHGSDPQLGarsLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAeGDSVDIFQTVKILRADRMQFVQTEEEYAFV
... ||.. .|| ||  .      | .....|..  .. ..  .||||  | ||||... |. .. ..   . ||....|. ||  |.. |||.. | |.
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YD
|.
yy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 789-1020 1.1e-28 95.0 In-house 35-273 (285) alignment 
Range on Protein: 789-1020
Range on HMM: 35-273/285.0
NHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK--G-IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDA--NSVQFGSY
|   ||| .   ..  ||.|   |.||| || |.  |  . |..||| ||| |.|||| .. . | . |.||    .   . || |.|.   . |.|| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVSTLSTSSDG-DMTI-RQLKVTRNSKTS-H--TVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKmnEFSILVHCLSGAGRTGVFCTAMECIAQI
 ..      .    ||   | |.    .|     . . |   || . . |.  || ...| . ||    |  |  | ||| .| |||  |     .  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla.pe.darpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatiri

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 |   ..... |. .|| |.| ||.  .. |.| |. ||.  |
menpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 501-738 9.6e-28 92.1 In-house 22-257 (290) alignment 
Range on Protein: 501-738
Range on HMM: 22-257/290.0
KNRYKNILpYDSARVKLEVIDNNPHSDYFNASYIpSFDNDKAYIASQGPNNAS-------TDDFWRMVWQENVTTIAMVTKLKEGDKI----KCGKYWPK
..|... |    .|| |..  .   .||. |... .. |. . |..| | ..          .|| |. ||.|. . |. . .| ..      | || |.
dqRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

IPGDSVKFGNIKVELVSLEACTGGIKRKMTMIKGDD-YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVV
  |...||....|.  | |.  . ..|....  .|.   |||   . .| .  |...| .||. |. |||     . | |.||  |. |  .. .|.   
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgy

AH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLedllwrntlI
   |.|.  | . . . ..|..|  ........||.  ...         .
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........l
PTPc_DSPc_SM00012 911-1014 1.4e-27 91.3 In-house 1-104 (105) alignment 
Range on Protein: 911-1014
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNKMN-EFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||   .    |...|.||||...|| . . ...|||  |.||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

VYDVIR
.|... 
lyrall
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 757-1025 4.6e-27 89.8 In-house 13-288 (307) alignment 
Range on Protein: 757-1025
Range on HMM: 13-288/307.0
RGRSKMTKEFQTLKSLCPDPPASHTrsgrTRDNHPKNRYGNNLPLQRNRVILDSP--DHDYINASQMkGIH---CTFMTTQMPLPTTVSDFWSLVLNYKP
.| .... ||. |    |.  . ..     . |  |||| .    ...|...  .    ||| |  . ||      |. .| || .|. .||..... | 
kgvqalvdefrvlakktpegvtvea....fsantdknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekv

STVVMLNDKSQNDK-SCAQYWPDAN--SVQFGSY----SVSTLST---SSDGD-MTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRA
 .|.|| .  .  |  | ||||  .     ||.     ||. | .   . | | . . .|||    . | |....|.. || .|  ||.   . . |. |
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgv.pqinl.tainllea

VKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY---LHTENYEQL
|.  ||      ..||| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| ... |. ||   |. | ||.|
vrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
0043147 (Phosphotyrosine protein) phosphatases II 811-1011 1.7e-26 88.4 In-house 3-155 (172) alignment 
Range on Protein: 811-1011
Range on HMM: 3-155/172.0
PDHDYINASQMKGIHCT--FMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKsqndkscaqywpdansvqfgsysvstlstssdgdmtirqlkVTRNSKT
...|||||| ... ...  |  || ||. |..||| .. ... ...|.|..                                          ..  .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

SHTVTQYQFHGWPKHGSDpqlGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAF
.... ||....|| ||      .. |..... ...  .. ..  .||||  | ||||... |  ..       .......|. .|. |.. ||... | |
erlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

VYD
.|.
lyy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 501-732 6.8e-26 85.7 In-house 46-277 (312) alignment 
Range on Protein: 501-732
Range on HMM: 46-277/312.0
KNRYKNILPYDSARVKLEViDNNphsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWpkipGDSVKFGNI
 ||| ||  .|  |  |   |.|    |  | ..    . . ....||| . ..  ||...     |.| ... . |    || ||      | | | ..
lnrypniqcwdrgrftlag.den...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi....sdivgfvdl

KVELVSLEACT-----GGIKRKMTM------IKG-DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVV
.   |  | ||     |  | |.|       .|   .   . .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.|..
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmi

AHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
|  .  |  .| .    .|. |   |..  || .   .||| | 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0051082 (Phosphotyrosine protein) phosphatases II 812-1013 1.2e-25 85.2 In-house 2-149 (151) alignment 
Range on Protein: 812-1013
Range on HMM: 2-149/151.0
DHDYINASQMKGIhctFMTTQMPLPttvsDFWSLVLNYKPSTVVMLNDKSQNDkSCAQYWPDANsvqfgsysvstlstssdgdmtirqlkvtrnsktsHT
  ||||.|.. |    .  ...||.    ||. |. ... .|.|.|...  ..  |..|.|...                                  ..
lsdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................ie

VTQYQFHGWPKHGsdPQLGARSLMKLIRAVKSstnkMNEFSILVHCLSGAGRTGVFCTAMECIAQiaegdsVDIFQTVKILRADRMQFVQTEEEYAFVYD
|.......|| .|   .|   ......... .    ...  .|||| .| ||||... .. .. .      |....... .|. |. .||..... |.. 
vlhipildwpdpg..lplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

VI
..
al
subfamily_CG42327_pd Subfamily CG42327 476-658 2.7e-25 83.7 In-house 8-192 (319) alignment 
Range on Protein: 476-658
Range on HMM: 8-192/319.0
SEEFHDLPgpNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSFDND-KAYIASQGPNNASTDDFWRMVWQENVTTIAMVTK
 |||.|||  ..  .. .       |.|. |..|   .|| |. | ..... |..|||.  .|.    |||.| . . |. ||||.||. .  .|  .|.
aeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LKEGDKIKCGKYWPKIPG-D-SVKFGNIKVELVSLEACTGGIKRKM--TMIKGDDYRTVTQFHFtEWPDKGVPKHTSSLLKFIKEVKA
| |    .| .|.|   . |    .|.|.| |   |.    .   .    ....  | .| . . .|.. .|| . ..|.  . ||..
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 761-1022 1e-24 81.8 In-house 25-293 (305) alignment 
Range on Protein: 761-1022
Range on HMM: 25-293/305.0
KMTKEFQTL-KSLCPDPPASHTRSGRTRD-NHPKNRYGNNLPLQRNRVILDSPD-HDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSLVLNYKPSTV
|. .||. | |   ||       . .. | .  |||| .    ... | || |   ||| |  .      .  |. .| ||  |. .|| .|.. |   .
klreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqi

VMLNDKSQNDK-SCAQYWPDANSVQF---GSYSVSTLST----SSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQlGARSlMKLIRAVKSStn
|||    .  |  |||||| |.  .    .   |  .|       | .. |  |..| . . . .| . |.  ||  |  |     | ..|. |.. |  
vmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc.klts.lellsairgs..

kmnEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHtENY
   .  |.||| .| ||||   .    . .|||  ..  . . || || .|   .|.. .| |.. |. .|.  |.|
...kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 822-1015 2.2e-24 80.7 In-house 86-284 (301) alignment 
Range on Protein: 822-1015
Range on HMM: 86-284/301.0
KGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPD--ANSVQFGSYSVSTLSTSS--DGDMTIRQLKVTRNSK--TSHTVTQ
.|    |..|| ||. |  ||| ..  |.  ..|||  | . . . |..| |   ..... | ... . .. .  . ... |.|.|.  ..  ...||| 
sGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvth

YQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCtAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAF-----
||.. |...|  |.  |  |..|.  || | .      |.||| .| ||.  |  . |..|.  | |  ... ...| || .| . |||..   .     
yqysewtdrgv.Pksha.elfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsqlywmtlGt

VYDVIRE
|| .|.|
vyrlike
0049260 (Phosphotyrosine protein) phosphatases II 826-1011 3.2e-24 80.8 In-house 9-144 (152) alignment 
Range on Protein: 826-1011
Range on HMM: 9-144/152.0
CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWpdansvqfgsysvstlstssdgdmtirqlkvtrnsktshtvtQYQFHGWPKHG
  |. || |.| |..||| .. ... .|.|||.. . ..|  |.||.                                          ||... || ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhg

SDPQLGARSLMKLIRAVKsstNKMNEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
  .       . |.       .. ..  .||||  | ||||... |  ..        |.....|. .|. |.. |.... . |.|.
vpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 498-728 9.3e-23 75.1 In-house 51-282 (302) alignment 
Range on Protein: 498-728
Range on HMM: 51-282/302.0
NFTKNRYKNILPYDSARVKLEvidnNPHSDYFNASYI--PSFDndKAYIASQGPNNAST---DDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPKIPG
|  ||. ...  .|| .||||    .   .| ||| .  |..   .  | .| |.  |.   ..|||||.||..... .. . .| .|    ...||  |
nlkknqsedvpildsnlvkle....aepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRT---VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVA
| ...|.. |     |   .  .| .  .  ...     ..  ..| |..| ||.. ..| | ...| | . . .....|    |.|| |....   .| 
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
. ..   . . . |..||..|| .|.. .||...| |.|
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
0048076 (Phosphotyrosine protein) phosphatases II 586-727 1.1e-22 75.6 In-house 2-139 (145) alignment 
Range on Protein: 586-727
Range on HMM: 2-139/145.0
YWPKIPGDSVKFGNIKVELVSLEACTGGIKR--KMTMIKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVIS
|||    ... .|.. . |   . .  ||..   .|. . . .|...|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||... 
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDSVVAhakttRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAV
.. .       . |.... .  .|..||..|....|. |.| ..
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 783-1019 1.2e-22 75.0 In-house 42-289 (305) alignment 
Range on Protein: 783-1019
Range on HMM: 42-289/305.0
SGRTRDNHPKNRYGNNLPLQRNRVILDSP-DHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVML-NDKSQNDKSCAQYWPDA--NS
. .  ... |||| .   |..||| |..|  |.|| |  .        |. || ||  | .||| . |. |  .. || | . .  | |..|..    . 
afkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

-----------VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTG
           |.| | .   . .... ..|  .| .    .... ||.| .  ||  |  .     ....|.   ..|        | ||| .| ||||
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarpskg.....pivvhcsagigrtg

VFCTAMECIAQIAEGDSVDIFQ-TVKILRADRMQFVQTEEEYAFVYDVIREYLHT
        . |. .|. ..  .  .. .| .| . .||...| ||..|| .|.. 
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 813-1014 2.5e-22 74.4 In-house 46-256 (290) alignment 
Range on Protein: 813-1014
Range on HMM: 46-256/290.0
HDYINASQMKGI-HCTFMTTQMPLPT-------TVSDFWSLVLNYKPSTVVMLNDKSQNDK-----SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTI
 ||| |....      .. || |.         |. .|| .. . |   |||| . .....     .||.| |..    ..|.  .|.  |   . |. .
ddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADR
|.| |. . .  .||| ....|| |    ..   ..|..||. || |.       ..|||  |  |  .. .       ||   .|| . . .| ||  |
RelvvkfddeeeftvtHsllkgWnklnvqed..tktllsliqkvkaskt.....pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

MQFVQTEEEYAFVYDVIR
 . .....|.|||  .| 
alaitsalelafvdagiv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 548-730 2.7e-22 73.6 In-house 98-287 (302) alignment 
Range on Protein: 548-730
Range on HMM: 98-287/302.0
GPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTGG----IKRKMTMI-------KGDDYRTVTQFHFTE
 | . ... .| .. | ||. .. .....|... || .|. .  |. .|||.  |. ||..          . |.  .       | .  .||  ..|. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKGVPKHTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
|||.| ||.. . |. .|  ..    . . ...|||||||||| ...|   .   .. .. |. . |. .|| |   ||...|  ..   |   
wpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 498-611 7.3e-22 72.5 In-house 47-169 (350) alignment 
Range on Protein: 498-611
Range on HMM: 47-169/350.0
NFTKNRYKNILPYDSARVKLE----VID----NNPHSDYFNASYIP------SFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKC
 |.||||||||||. .||||.      |        .|| ||.|.       . . |  ||| |.|     |||.... . .|. | ..|.. | .  ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

GKYWPKIpgdsvKFGNIKVELVSLEACT
 .||..      .. .|.| | |    .
yrYWqeg.....sydditvklaskweni
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 789-1024 1.7e-21 71.6 In-house 43-278 (288) alignment 
Range on Protein: 789-1024
Range on HMM: 43-278/288.0
NHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYS
|  ..|| |       || |.   . ||.|  .   .    .. .| || .|.  .| ..|.     .|||..  .  |   |.|.|    .....| . 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VSTLSTSSDGDMTIR--QLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGD
  .    .| | ...   |..... ...  | .  .. |...|   .    | ..|.  .|| ..      |.||.  |.|||| .   .  . ..   |
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPeny..lsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrldd

SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
 . | . .. ||..|.. .|||  | .|. .. |.|    |..
flgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 827-1012 3.3e-21 70.4 In-house 5-198 (198) alignment 
Range on Protein: 827-1012
Range on HMM: 5-198/198.0
TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT---SHTVTQYQFHGW
 ...|| ||  |..||| .| .     .||.||  .| .   . ||| ..|   ..|| ||.| . ..  |.||  | .| |. .   .  ...|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHgSDPQLG-ARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .. . |..     ..   | |    .. ..  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
kek.ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 827-1012 3.5e-21 70.3 In-house 6-199 (199) alignment 
Range on Protein: 827-1012
Range on HMM: 6-199/199.0
TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT---SHTVTQYQFHGW
 ...|| ||  |..||| .| .     .||.||  .| .   . ||| ..|   ..|| ||.| . ..  |.||  | .| |. .   .  ...|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHgSDPQLG-ARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .. . |..     ..   | |    .. ..  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
kek.ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 540-724 5.2e-21 69.7 In-house 4-197 (199) alignment 
Range on Protein: 540-724
Range on HMM: 4-197/199.0
DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTG-----GIKRKMTmIKGDDYRTVTQFHF
.. |||.| |   .  |||.|||.     | ||   .   .     |||     . |.|.. |   .. .         |  . |       | .... |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.tappstreishyqf

TEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
| | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..| |||
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 540-724 5.3e-21 69.7 In-house 3-196 (198) alignment 
Range on Protein: 540-724
Range on HMM: 3-196/198.0
DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEACTG-----GIKRKMTmIKGDDYRTVTQFHF
.. |||.| |   .  |||.|||.     | ||   .   .     |||     . |.|.. |   .. .         |  . |       | .... |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.tappstreishyqf

TEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
| | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..| |||
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0048179 (Phosphotyrosine protein) phosphatases II 613-724 5.4e-21 70.3 In-house 29-138 (144) alignment 
Range on Protein: 613-724
Range on HMM: 29-138/144.0
GIKRKMTMIKG----DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDSVVahakTTRmVDVFNFVTNIRQ
||.   ... .    .  |...|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||... .. ..    . . ..... .  .|.
gittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrs

KRPYMVQTQEQYAFIY
.||..|....|. |..
rrpgavpnpgqlrfLl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 907-1019 3.7e-20 66.7 In-house 86-196 (440) alignment 
Range on Protein: 907-1019
Range on HMM: 86-196/440.0
KTSHTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEY
  |.|. ||...||| .|  |.. |  ..|.|. |. | .|  .  .|||| .|||||||  .    . .    | .|||  .. .| .| |.||| |.|
iesrtlkqyhyqgwpdkgv.pkf.agpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

AFVYDVIREYLHT
|||.... | | .
afvheavlegllc
0044763 (Phosphotyrosine protein) phosphatases II 802-1018 7.1e-20 66.8 In-house 3-172 (178) alignment 
Range on Protein: 802-1018
Range on HMM: 3-172/178.0
QRNRVILDSPDH----DYINASQMKGIhcTFMTTQMPlpttvSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDANSvqfgsysvstlstssdgdmt
 |.||.|... .    ||||||.. .    ..... |     .|.. |. ... ...|.|..   .   .| .|||. ..                    
drtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag....................

irqlkvtrnsktshtvTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSSTNkmneFSILVHCLSGAGRTGVFCTAMECIAQiaegdSVDIFQTVKILRAD
                 ||.. ..| ||  .     . ....|... .. .      .||||  | ||.|... |  .. .     ...... .. .|. 
................iqylhipipDhgvpdllehflefvefieealdekg....gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RMqFVQTEEEYAFVYDVIREYLH
|. .|.... . ..|.. ...| 
Rp.ivpnpgqlrqLyefelrllk
subfamily_eak_pd Subfamily eak 493-737 1.1e-19 65.0 In-house 47-311 (332) alignment 
Range on Protein: 493-737
Range on HMM: 47-311/332.0
AQEEINFTKNrYKNILPYDSARVKLEVIDNNPHsDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPG
..   .  .|   .|.|||   |.|     |.   | ||| .   .  . || .  ...     ||.|| ...  .| .. .  | .  |  ||.|.   
tarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

DSVKFGNIKVELVSLEACTGGIKRKMTMIKGDDYRTVTQFHFTEWPDKGVPKHTS--SLLKFIKEVKA------------------DHGQFTHPLIIHCS
. .||| ..||  .         |.. . ||..   |  ...  | .  .||     .| | .||| .                   |   ..  || ..
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsa

AGVGRTGVVISIDSVVA--HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
 |  |.|| . || ..    .| . .  | ...  ...|| . | .. |..||| .||. || ||  
rGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 535-731 4.9e-19 63.4 In-house 27-221 (255) alignment 
Range on Protein: 535-731
Range on HMM: 27-221/255.0
PSFDNDKAYIASQgpnnaSTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSleACTGGIK--RKMTMIKG--DDYRTVT
|. |...  . |      . | |.... | . ....|.. ..| .. || .|.|    .  |. ...|      . .  .   ...|   |     .||.
Pekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA------HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 .... |..|  |. .  .|. .| |.       .....|||.|.||.   . ...|        .   |  .|  ......|.||.  ..|  | ||  
hysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

GAVLEDL
  ||. .
lmvldlv
subfamily_egg_pd Subfamily egg 809-1015 1.1e-18 61.9 In-house 68-268 (307) alignment 
Range on Protein: 809-1015
Range on HMM: 68-268/307.0
DspdhDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNdKSCAQYWPDAN--SVQF--GSYSVSTLSTSSDGD--MTIRQL
|    |.| | ..||  .  .|. .| ||  || ||| .| . .   .|||. . .. . |  ||| |.  |...  ||. . .|   |  |  ... .|
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

KVTRNSKTSHTVTQYQFHgWpKHGSDpqlgARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGDS--VDIFQTVKILRADRMQ
|.    .    .  .|   . .. ||      | ....| ..  ..      ..|..  |  ..... ..   . ..  |      . ..|. ||  |  
klvGgddeerflehwqgd.v.nnssd....vysplrvlrklrnlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

FVQTEEEYAFVYDVIRE
 |..   | ||| ..  
svesvllylfvyrlvlf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 838-1017 1.8e-18 61.6 In-house 40-221 (255) alignment 
Range on Protein: 838-1017
Range on HMM: 40-221/255.0
TVSDFWSLVLNYKPSTVVMLNDKSQ-NDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN---SKTSHTVTQYQFHGWPKHGSdPQLgARS
||  |.  .   |...|||| |  . . . | .|.|     .     |.  .| |  |. .| |..| .    |  |||. |...||... . |.| || 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna.Pel.are

LMKLIRAVKSStnKmnefSILVHCLSGAGRTGVFCTAmECIAQ-----IAE--GDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.......|. |  |    |..||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|  . ||   .. ...
ilnilkvvrds..k....svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 787-926 2.1e-18 61.2 In-house 31-180 (297) alignment 
Range on Protein: 787-926
Range on HMM: 31-180/297.0
RDNHPKNRYGNNLPLQRNRVILD--SPDHDYINASQMK----GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDAN--SV
     |||| . |  . .|| |    ...|||||  .          .. .| || .|| ||| || .    ..||.    ..  . || |||...    
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

QFGSYSVSTLSTSSDG--DMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSD
. |.. |  ||. ||    . . .|..    . |  |.  || .|| ||  
kagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvp
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 762-1021 3.2e-18 60.5 In-house 21-280 (312) alignment 
Range on Protein: 762-1021
Range on HMM: 21-280/312.0
MTKEFQTLKSLCPDPPAshTRSGRTRDnhpKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND
.|||....  . .|     |   . .|    ||| |    .| |  |   .  || |  .|       |..|| ||  |.. || |.|.   .....|  
ltkeykavgnivsdsec..taflkfkd...lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

KSQ-NDKSCAQYWPDAN-SVQFGSYSVSTL-------STSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmn
  .   . ||.|  |    |..  . | |           |   .| | |||  ..      . .||.  || ||        . ..|. |||   .   
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds..cdtalrllsavkkdkk...

efSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
   .. || .| |||| ..     || .      .. ..  .|| || . |..  .| ..  .. |.|... 
..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 497-732 7.9e-18 59.1 In-house 46-280 (303) alignment 
Range on Protein: 497-732
Range on HMM: 46-280/303.0
INFTKNRYKNILPYDSARVKLEvidnnpHSDYFNASYIpSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIpGDSVK
 |. |||. ...  | ..|||        | |  |||.  .| .|  | .| | . .. |||.|. ...|  . ..    | ||.     .|.   | .|
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflk

FGN--IKV-ELVSLEACTgGIKRKMTMIKGDDYRTVT-QFHFTEWPDKGVPKH-TSSLLKFIKEVKADHGQFT--HPLIIHCSAGVGRTGVVISIDSV--
| .  |.| |.  .|    | . |.  .   ||..     |. .|| . .| . .. ..| | ....   ...  .| .    .|.||.|    ...   
feersirvgefkrvelgd.gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

VAHAkTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
  |.     .|. . . |.|. | . ||   |....|  . | .|
slhs.eqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 767-1016 1.1e-17 58.7 In-house 15-268 (281) alignment 
Range on Protein: 767-1016
Range on HMM: 15-268/281.0
QTLKSLCPDPPASHTRSGRTRDNHPKNRYGNNLPLQRNRVILDS--P---DHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND
| .  |  |||.          |  |||| |   |.  || |    |     ||| |  ..   ..  .. || |   | .||| .. . . ...||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

K-SQNDKSCAQYWPDAN--SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNkmnefSILVH
    | . ||.|.|      .||  .|||   .. .  .   .|... . .| . .|.. .. ||     |.  .  ..|..| ... .        ..|
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqv.pe.ssevmlkilrkirarst.....ppvih

CLSGAGRTGVFCTAMECIAQIAE-GDSVDIFQTVKILRA-DRMQFVQTEEEYAFVYDVIREY
| .| ||.| . .   ..  |       || | |  ||   |   ||| ..| ... |. ..
csagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 787-1018 1.4e-17 58.1 In-house 49-286 (302) alignment 
Range on Protein: 787-1018
Range on HMM: 49-286/302.0
RDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC--TFMTTQMPLPTTV---SDFWSLVLNYKPSTVVMLNDKSQNDKSCAQYWP--DANSVQF
..|  ||.  .   |. |.|.|.    .|.|||...  ..  . . .|.|  ...    .|| .| . |  .||.|  . . .|.  ...|    . ...
kknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykey

GSYSVSTLSTSSDGDMTiR--QLKVT-RNSKTSHTVTQYQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMNEFSIlVHCLSGAGRTGVFCTAMECIAQ
|.  | .   ..  ...     . |   .   |  .. | .. |...         .|.| .  |  .. | .| .. .    |||| |.| |..  . .
gkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp..vkyaeliktaakvfakkikadentv.ivSknGaGRagafltlavavek

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
. .|. . | ..|| .|..| . |.. . |...| ..  |. 
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 655-731 1.7e-17 58.3 In-house 220-295 (297) alignment 
Range on Protein: 655-731
Range on HMM: 220-295/297.0
EVKADHGQfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
 ..|.. .   .|..||||||||.|||.  | ..|  .  |. ||  ... .|..|. .||| ||. ..| |||. |
slraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 786-1026 3.9e-17 56.8 In-house 44-288 (303) alignment 
Range on Protein: 786-1026
Range on HMM: 44-288/303.0
TRDNHPKNRYGNNLPLQRNRVILDspDHDYINASQMKG-IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDKSCAQ-YWPDA-NSVQFGSY
  .|  |||. . . |.  .| |   |  || || ..   .   . ||.||. | .||| .... |   |..|   |. ||   .  .|   . ..|   
fvknmdknrfvdvicldhskvkls..dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeer

SVSTLSTSSDGDMTIRQLKVTRNSKTS--HTVTQYQFHGWPkHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILV-HCLSGAGRTGVFCTAM-ECIAQIA
|.          .   .|||   |. .    .  .... || |.| |  |.  ..| |  ..|   |  . .  |   ||| ||.| |.      ..  .
sirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhs

EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQLP
|  |.|. . .. .|  |.. ||   ....|| .. |..  . . .| 
eqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla
subfamily_hpo-7_pd Subfamily hpo-7 836-1008 1.1e-16 55.6 In-house 44-218 (263) alignment 
Range on Protein: 836-1008
Range on HMM: 44-218/263.0
PTTVSDFWSLVLNYKPSTVVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR---NSKTSHTVTQYQFHGWPKHgSDPQLgA
  |.  |.. .   |...|||| |   .  . | .|.|     .     |.  .| .  |. .. |...    . |. |||..|.. ||...  ||.| |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek.ndpel.a

RSLMKLIRAVKSStnKmnefSILVHCLSGAGRTGVFCTAmECIAQ-----IAEGD--SVDIFQTVKILRADRMQFVQTEEEYAF
|. ........ |  |    |. ||| .| ||.  |  | | . |     . . .   .|  . .. ||  | . ..|    ||
reilnilkvarns..k....slvvhcstGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_CG42327_pd Subfamily CG42327 662-726 2.1e-16 54.5 In-house 245-310 (319) alignment 
Range on Protein: 662-726
Range on HMM: 245-310/319.0
QFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
.   ||..||| ||||||.||. |  . . ... | ||. . |  .|. |   |.|.|||.|||  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_eak_pd Subfamily eak 781-1021 3.5e-16 53.5 In-house 44-309 (332) alignment 
Range on Protein: 781-1021
Range on HMM: 44-309/332.0
TRSGRTRDNHPKNRYGnNLPLQRNRVILDSPD---HDYINASQMK--GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDA
 . ..  ..  .| ..  .| .|. | | |       ||||| ..   .   .. | ..  . |  || .||. |  ..|.| .. ... .   .|.|| 
isetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

N--SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSD------------PQLGARSLMKLIRAVKSSTNKM-----NEFSILV
    ..|| . | . .    . .  |.|....  .| | |  |...|| .                 . |.  |.    |. ||| |        |. ..
treelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii

HCLSGAGRTGVFCTAMECIaQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 .  |. |.|||      | .. ..    .  . . .   .  |.  | .. ...|.|... .|| . |
qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_CG42327_pd Subfamily CG42327 789-944 4.8e-16 53.3 In-house 28-193 (319) alignment 
Range on Protein: 789-944
Range on HMM: 28-193/319.0
NHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQND-KSCAQYWPDAN----S
 ..|.|. | .||   ||.|..    .   |..|| ..|    .. ....|..|  . |||| .| . .  ..| | | |..  | ||.|.|  .     
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

VQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFhGWPKHGSDPQlgARSLMKLIRAVKSS
  .| . |.     ..    |  | . |   . |  .| | .  |.. .   .   ..|. ..  |.||
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPae..eaaliamllevrss
subfamily_hpo-7_pd Subfamily hpo-7 553-729 6.1e-16 53.1 In-house 46-225 (263) alignment 
Range on Protein: 553-729
Range on HMM: 46-225/263.0
STDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPKIPGDSVKFGNIKVELVSLEActGGIKRKMTMIK--G--DDYRTVTQFHFTEWPDKGVPKHTSS
  | |.... | . ....|..  .| .. || .|.|    .  |. |..|           ...   ...  |     .||... .. |..|  |. . .
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA----H--AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 |. .| ..       ..|..|||.|.||.     ...|            |  .|  ......|..|.  ..|  | ||    ||.
ilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 668-731 6.9e-16 52.4 In-house 2-65 (69) alignment 
Range on Protein: 668-731
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 827-891 6.9e-16 52.6 In-house 237-300 (440) alignment 
Range on Protein: 827-891
Range on HMM: 237-300/440.0
TFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDksQNDKSCAQYWP-DANSVQFGSYSVSTLSTSS
.|..||||| .|| ||| || .|. ||..|||.   |||.|. ||| .. || || ..|    .  
afiatqmpldstvldfwrlvhdyristiimlnq..lndktcsiywpvntrsvtfgpftvghkgsen
0048076 (Phosphotyrosine protein) phosphatases II 906-1016 9.5e-16 53.2 In-house 41-142 (145) alignment 
Range on Protein: 906-1016
Range on HMM: 41-142/145.0
SKTSHTVTQYQFHGWPKHGSDPQ-LGARSLMKLIRAVKSStnkmnEFSILVHCLSGAGRTGVFCTAMECIAqiaegDSVDIFQTVKILRADRMQFVQTEE
.  .....||.. .|| ||  .     ......|... ..     .  .||||  | ||||... |. ..       .|....... .|. |...|....
ellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpg

EYAFVYDVIREY
 . |.|....|.
qlrflyefelel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 833-1009 1.2e-15 51.8 In-house 98-280 (302) alignment 
Range on Protein: 833-1009
Range on HMM: 98-280/302.0
MPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDGD-------MTIRQLKVTR---NSKTSHTVTQYQFHG
.|   |.  .|.|. .|. . || | . . ...| ||.|. |   . ..|| |.| |.|   | .       ... .....    ..|. .||   .| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPKHGSdPQLgARSLMKLIRAVKSStnKMnefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
||.||. |.  | . .....  .|   |    ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   ..
wpdhGa.pke.aytaldilkfcesy..kk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 788-1013 1.5e-15 51.6 In-house 51-286 (310) alignment 
Range on Protein: 788-1013
Range on HMM: 51-286/310.0
DNHPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDK-SCAQYWPDANS-VQFG
..  |||| . . |.  || |    |  .||| |  .|   .  ||. .| ||  |. ||| .... .  ....|   ... .  |  |||       .|
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

SYSVSTLSTSSDgDMTIRQLKVTRNSKT-----------SHTVTQYQFHGWPKHGSDPQLGARSLMKLIRavksstnKMNEFSILVHCLSGAGRTGVFCT
   |. || ||. .. | .| ||                   |.  ..  ||  |   .       .|.        ..     .||| .| .|..| ..
cirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla.......qvrhgpcvvhcsagkdrlyvvva

AMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
    | .. .|. ||. . .  |. .|.. .||| .| ..  | 
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 668-731 1.8e-15 51.0 In-house 1-64 (69) alignment 
Range on Protein: 668-731
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
0048179 (Phosphotyrosine protein) phosphatases II 899-1011 8.3e-15 50.3 In-house 48-139 (144) alignment 
Range on Protein: 899-1011
Range on HMM: 48-139/144.0
QlkvtrnsktshtVTQYQFHGWPKHGSDPQ-LGARSLMKLIRAVKSstnkmNEFSILVHCLSGAGRTGVFCTAMECIaqiAEGdsVDIFQTVKILRADRM
.            ..||.. .|| ||  .     ......|... .     ..  .||||  | ||||....|  ..    .|  ........ .|. |.
e............giqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrp

QFVQTEEEYAFVYD
. |.... . |...
gavpnpgqlrfLle
fn3 Fibronectin type III domain 240-329 1e-14 47.6 Pfam-A 2-85 (85) alignment 
Range on Protein: 240-329
Range on HMM: 2-85/85.0
SPINVAIPRSTTSSFTVSWSTPLpsNINGDIQKYIIRFKQTDPVVdgdyKSEEVLNSAFEEEHTVVDLTAKTSYSVQVQTVNGAGSSNWS
.| |. .   |..|.|.||| |   . .|.|..| .......       .. |. ... ....|. .|.. |.|...||.||||| . .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 618-728 1.8e-14 48.2 In-house 207-341 (350) alignment 
Range on Protein: 618-728
Range on HMM: 207-341/350.0
MTMIKGDDYRtVTQFHFTEWPDKGVPKHTSSLLKFIK-------EVK-ADHG--QFTHPLIIHCSAGVGRTGVVISIDSVVA-------------HAK-T
.|.   | |  | |...  |.| ..  .  |.|. ..       .     |   . . |...||||||||||.....||..              . . .
itlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

TRMVD-VFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
... | ..  | ..|..|  |||. .|. ||| |.|
aktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 453-537 2.4e-14 47.5 In-house 2-86 (440) alignment 
Range on Protein: 453-537
Range on HMM: 2-86/440.0
SNKPIPLAQFPAFVNKNRHTALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNASYIPSF
|..|| .|.|  .|..|| .  | .|.  ||     |  .|    |  ||||.||| || .|| || .   |.||| ||||| . 
sqrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 726-927 7.1e-14 46.0 In-house 34-237 (244) alignment 
Range on Protein: 726-927
Range on HMM: 34-237/244.0
AVLEDLLWRNTLIPVVHFTDHlQDLHSSGDGRGRSKMTKEF-QTLKS-LCPDPpaSHTRSGRTRDNHPKNRYGNNLPLQRNRVILD--SPDHDYINASQM
|||     .|  | .. | .  . . ||    |   .  .. |  .. . |||  |  .     .|  ||| |  ||.. ||| |   |    ||||| .
avlsanatknryinilpfdet.rvilssskkegsdyinanyiqgsqniirpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv

K--GIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDkscaQYWPDANSVQFGSYSVSTLSTSSDGDMTIR--QLKVTRNSKTSH-TVTQYQ
   |  . .. || ||  |  ||| ..|. .   .|.|    ..|    .||||.. ...    ..   |  |    |.  .|..  . . || ..| .|
gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfq

FHGWPKHGSDP
   ||  |. |
isnwpsdgttp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 790-877 9.3e-14 45.9 In-house 48-156 (350) alignment 
Range on Protein: 790-877
Range on HMM: 48-156/350.0
HPKNRYGNNLPLQRNRVILD----S--------PDHDYINASQMK------GIHCTF--MTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCA
  |||| | ||  ..||.|     |           |||||. .|       |   |  . || ||| || ||. ..|. |   ...|..   .| . | 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPDANSV
.||.. .  
rYWqegsyd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 498-605 9.5e-14 45.5 In-house 48-173 (349) alignment 
Range on Protein: 498-605
Range on HMM: 48-173/349.0
NFTKNRYKNILPYDSARVKLEVIDNNP--------------HSDYFNASYI--PSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDKI
 |.|||||.||||. .||||.   ...                || || |.  . .. .| ||| | |  .. |||....  ..|  .  ... || .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCGKYWPKIP--GDSVKFGNIKVELV
|| .|| .    .  ||. |     .
kcdiywqelsysnitvklqnsslyia
subfamily_CG42327_pd Subfamily CG42327 942-1016 1.6e-13 45.0 In-house 238-314 (319) alignment 
Range on Protein: 942-1016
Range on HMM: 238-314/319.0
KS-STNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
 | | .. .   . |||  |.||||.  ..   | .. |   |||| |.|  .| || . |.| | |.|.| |. ||
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 955-1017 3.5e-13 43.7 In-house 2-64 (69) alignment 
Range on Protein: 955-1017
Range on HMM: 2-64/69.0
VHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| |..| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 954-1017 4.3e-13 43.5 In-house 2-65 (69) alignment 
Range on Protein: 954-1017
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || |..| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 472-548 4.9e-12 39.9 In-house 22-95 (95) alignment 
Range on Protein: 472-548
Range on HMM: 22-95/95.0
TALFSEEFHDLPGPNIYPQTVAQEEINFTKNRYKNILPYDSARVKLEVidnNPHSDYFNASYIPSFDNDKAYIASQG
   | .||. ..     | ||   | |  |||. ||.|||..|| |     .  ||| || ..  .   ..|||.||
dqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 75-151 1.5e-10 34.2 Pfam-A 9-81 (85) alignment 
Range on Protein: 75-151
Range on HMM: 9-81/85.0
VSTTSTTVGLQWNAWSekddIGDPPLVGYDVFVKEDGDW--VTDQRVDPLPTSAIVSNLTADTEYMFRVAAVREGRggT
 ..|||.. |.|.. .     |. |..||.| ..|.|.    . ..|..  ||.....|...||| |||.|| ..   .
sevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag..e
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 949-1013 3.8e-10 34.1 In-house 227-291 (297) alignment 
Range on Protein: 949-1013
Range on HMM: 227-291/297.0
NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 .  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. ..||..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 800-927 7.3e-10 33.3 In-house 4-128 (130) alignment 
Range on Protein: 800-927
Range on HMM: 4-128/130.0
PLQRNRVIldspDHDYINASQM--KGIHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDKSQNDkscaQYWPDANSVQFGSYSVSTLSTSSDGDMTI
. . .|.     ...||||| .   |    .. || ||  |  ||| ..|.     .|.|    ..|    .||||.. ...    .   .|  |.   |
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefkni

R--QLKVTRNSKTSH-TVTQYQFHGWPKHGSDP
.  .|.. .. . || ..| .|   ||  |. |
kasnleiesdlneshqaltmfqisnwpsdgttp
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 831-1017 1.1e-09 31.4 In-house 123-309 (346) alignment 
Range on Protein: 831-1017
Range on HMM: 123-309/346.0
TQMPLPTTVSDFWSLVLNYKPSTVVM-LNDKSQNDKSCAQYWPDANSVQF-GSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQ
 ||   . | ||| .. . .   | . . |   .. . . .  .    |. |   .    .   ||     ..|  . ..   . | . |   ||  .| 
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqpp

LgARSLMKLIRAVKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  .  ..|.|   .|  .....  . |  | |.||.  |  |.  | |. .|   .|.. .| .. .|   |..  .|| .| .. .|.
k.tlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 911-1017 1.8e-09 31.8 In-house 216-344 (350) alignment 
Range on Protein: 911-1017
Range on HMM: 216-344/350.0
TVTQYQFHGWPKHG--SDPQLGARSLM---KLIRAVKSS--TNKMNEFSILVHCLSGAGRTGVFCTAMECIA------QIAEG---------DSVDIFQT
 | | |.. |.  .   .|.   ..|    .||    .    .. .  .||||| .| ||||...|    .       .. .              |...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKILRADRMQFVQTEEEYAFVYDVIREYL
|..||  |.. ||. . . |.|. .. | 
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 487-582 2.6e-09 31.0 In-house 23-117 (332) alignment 
Range on Protein: 487-582
Range on HMM: 23-117/332.0
IYPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNnpHSDYFNASYIPSFDNDKAYIASQGPNNASTDD-FWRMVWQENVTTIAMVTKLKEGDKIK
 ||.|  .   |.  ||   .  .| .||.|   |   . |..|||..  . .  ||| .| | |  |.  ||||| . . . | ..  . | .| |
typntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 629-728 8.2e-09 29.2 In-house 220-341 (349) alignment 
Range on Protein: 629-728
Range on HMM: 220-341/349.0
VTQFHFTEWPDKGVPKHTSSLLKFIKeVKADH-----------GQFTHPLIIHCSAGVGRTGVVISIDSVVA----HAK-------TTRMVDVFNFVTNI
. |. . .|.| ..     |.|. .. || |             . . .|..||||| |||||.. .|....      .        . . |.  .. |.
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

-RQKRPYMVQTQEQYAFIYGAVL
 |..|  |||   |. .|| |.|
lrkqrismvqnlaqfiaiyealL
subfamily_PTPDC1_pd Subfamily PTPDC1 631-722 1.1e-08 29.7 In-house 84-167 (182) alignment 
Range on Protein: 631-722
Range on HMM: 84-167/182.0
QFHFTEWPDKGVPKHTsSLLKFIKEVKADHGQFthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRmvdvfNFVTNIRQKRPYMVQTQEQYAF
 ..   |.| ||.  . ..|  .| |.    .    . .|| || |||||.|.   | |.  |.      . .. .|.|||  .||.||  .
yvynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 813-875 1.4e-08 28.5 In-house 90-157 (349) alignment 
Range on Protein: 813-875
Range on HMM: 90-157/349.0
HDYINASQMKG----IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLND-KSQNDKSCAQYWPDAN
.|||||  .|     ..  ...||.|||.|| ||. ..|. .   |. ||| | .. . | .|| . .
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 491-574 1.6e-08 28.5 In-house 30-118 (347) alignment 
Range on Protein: 491-574
Range on HMM: 30-118/347.0
TVAQEEINFTKNRYKNILPYDSARVKLE-----VIDNNPHSDYFNASYIpSFDN-DKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTK
|... | . .||| |.    |..|| |          ..   | |||.|  ||| .| || .| |   .  |||.||   .|| .  . .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 539-602 6.8e-08 26.2 In-house 234-293 (440) alignment 
Range on Protein: 539-602
Range on HMM: 234-293/440.0
NDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKegDKiKCGKYWPkIPGDSVKFGNIKV
. .|.||.| | ...  ||||.| . ...|| |. .|.  ||  |  ||| .   || || . |
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywp.vntrsvtfgpftv
0038934 (Phosphotyrosine protein) phosphatases II 631-723 1.5e-07 26.7 In-house 81-169 (194) alignment 
Range on Protein: 631-723
Range on HMM: 81-169/194.0
QFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF-THPLIIHCSAGVGRTGVVIsidsvVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFI
...   .||.|..  .. ||.|.. |.  . .   .   .|| ||.||||...     .|.   ..  ..   .  .|.||| ....|...  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdyleal
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 547-729 2.5e-07 23.6 In-house 124-307 (346) alignment 
Range on Protein: 547-729
Range on HMM: 124-307/346.0
QGPNNASTDDFWRMVWQENVTTIAMvtkLKEGDKIKC--GKYWPKIPGDSVKFGNIKVELVSleACTGGIKRKMT---MIKGDDYRTVTQF-HFTEWPDK
|  |..  .||| |..||..  . .   .   ||.|      .    |     |.. ..     |   |  .. |   . .|.    . |  | . |   
qmenesfvedfwymiyqeqihlvyl...mvpddklkntttslfndenggyqytgkmfinnrr..advsgdpkeytievlpegnsdsvicqvhhhapwkhl

GVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
  | .|  ..|.|.. ....   .  . .    | ||.   |     .         .... . ||.|.||  |..  ||| ||  |..
qqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 905-1017 3.8e-07 23.7 In-house 213-344 (349) alignment 
Range on Protein: 905-1017
Range on HMM: 213-344/349.0
NSKTSHTVTQYQFHGWPKHGSdpQLGARSLMKLI-------RAVKS--STNKMNEFSILVHCLSGAGRTGVFCTAMECIA--QIAEGDSVD---------
...  . . | |.  |.  .    |   |... .           .    .. .  ..|||| .| |||||..|    ..  .  . .|.          
avekPyellqlqvknwldlsl..llnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

-IFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 |. .| .||  |.. ||   .. ..|. . .|.
lisiivnelrkqrismvqnlaqfiaiyealLkyf
fn3 Fibronectin type III domain 169-226 5.4e-07 22.8 Pfam-A 25-85 (85) alignment 
Range on Protein: 169-226
Range on HMM: 25-85/85.0
DCRSGVTHYMIYYAAS-TS--SNSLTVPNDTSFYTIRELDTYLDYTIQLTASNKDEESDRS
| .. .|.| . |. . ..  ... |||..|. .|...|  . .|.....| |.. |. .|
dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
ODV-E18 Occlusion-derived virus envelope protein ODV-E18 355-393 8.5e-07 17.2 Pfam-A 29-67 (85) alignment 
Range on Protein: 355-393
Range on HMM: 29-67/85.0
AILIILIIIIVVIIVFKRRRNDSNPSKKENIEDQFQAPL
 ||| |.||| .|..|.   |... |.... . .|. ||
tiLivlViiiLlilLfqsSSngnssssaattraaftnpl
subfamily_PTPDC1_pd Subfamily PTPDC1 929-1011 9.4e-07 23.4 In-house 93-170 (182) alignment 
Range on Protein: 929-1011
Range on HMM: 93-170/182.0
LGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDsvdifQTVKILRADRMQFVQTEEEYAFVYD
 |..|| ...  ||  .  ..|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .| .
ygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 811-870 9.5e-07 22.6 In-house 68-128 (347) alignment 
Range on Protein: 811-870
Range on HMM: 68-128/347.0
PDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSLVLNYKPSTVVMLNDkSQNDKSCAQY
. . |||||..|    .  .. || ||| || ||| .|   | . || . .  ..|..  ..
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife.pikdeaieef
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 488-537 1e-06 22.6 In-house 29-77 (244) alignment 
Range on Protein: 488-537
Range on HMM: 29-77/244.0
YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDnNPHSDYFNASYIPSF
. || |    | ||||| ||||.| .|| |     .  ||| ||.|| . 
flqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 863-1013 1.5e-06 21.9 In-house 146-298 (332) alignment 
Range on Protein: 863-1013
Range on HMM: 146-298/332.0
NDKSCAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSDPQ--LGARSLMKLIRAVKSSTNKMNEFSILVHCLS
. | | ..||. .|  .| . |. .    |.  |   .| || . |  |     .|. |      |.  |  |. .||     |    .    |.. | .
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtek.kqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
|  .  ...|    ...|.|   | . .|.  .. .|.  ..|   |.   ...
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystaceml
0038934 (Phosphotyrosine protein) phosphatases II 919-969 3e-06 22.5 In-house 84-134 (194) alignment 
Range on Protein: 919-969
Range on HMM: 84-134/194.0
G--WPKHGSDPQLgaRSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCT
   .| .|. |.|    |.. ...|.  .|. ..  ..|||  | ||||... 
klpfpddgtvPsl..eillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 489-645 3.1e-06 20.1 In-house 17-156 (169) alignment 
Range on Protein: 489-645
Range on HMM: 17-156/169.0
PQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNAsyipsfdndkayiasqgpnnastddfwRMVWQENVTTIAMVTKLKEGdkikcGKYWP
 . .|.  .| ||||    |    .||||. . ..  ||| ||                           ||.|. | . | ..    .        .||
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwp

KIPGDS----VKFGN-----IKVELVSLEACTGGIKR--KMTMIKGDDYRTVTQ----FHFTEWPDKGVPKH
.         | .|.     . |    ..  | |..   ........  ..||.    .|.. ||..|||. 
ekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 488-645 4.6e-06 19.7 In-house 17-157 (169) alignment 
Range on Protein: 488-645
Range on HMM: 17-157/169.0
YPQTVAQEEINFTKNRYKNILPYDSARVKLEVIDNNPHSDYFNAsyipsfdndkayiasqgpnnastddfwRMVWQENVTTIAMVTKLKEGdkikcGKYW
| . .|.  .| ||||    |    .||||. . ..  ||| ||                           ||.|. | . | ..    .        .|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfw

PKIPGD----SVKFGN-----IKVELVSLEACTGG----IKRKMTMIKGDDYRT--VTQFHFTEWPDKGVPKH
|.        .| .|.     . |    ..| | |    ..  | . . ||  |  .. .|.. ||..|||. 
pekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 740-823 5.5e-06 20.5 In-house 7-83 (95) alignment 
Range on Protein: 740-823
Range on HMM: 7-83/95.0
VVHFTDHLQDLHSSGDgrgrSKMTKEFqtlKSLCPDPPASHTrSGRTRDNHPKNRYGNNLPLQRNRVILDS-PDHDYINASQMKG
|  |  |. ..||  |     .. .||   ||.     |..|  | .  | ||||. | .| .  ||.| .  | |||||  . |
vsvfhshvlemhsnsd....qefdnef...ksismtsgapyt.vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 508-641 5.6e-06 20.7 In-house 3-125 (130) alignment 
Range on Protein: 508-641
Range on HMM: 3-125/130.0
LPYDSARVKlevidnnpHSDYFNASYIPSFDNDKAYIASQGPNNASTDDFWRMVWQENVTTIAMVTKLKEGDkikcgKYWPKIPGDSVKFGNIKVELVSL
|... .|..          .| |||..   .. . |. .| |  ... |||.|. .  |  . ..  ..| |     .|||          .| | |   
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

EACtGGIKRKMTMIKGDDYR---TVTQFHFTEWPDKG
.     || .   |. |  .   ..| |. ..||  |
def.knikasnleiesdlneshqaltmfqisnwpsdg
EphA2_TM Ephrin type-A receptor 2 transmembrane domain 349-385 8.3e-06 17.2 Pfam-A 3-39 (75) alignment 
Range on Protein: 349-385
Range on HMM: 3-39/75.0
AGGAVGAILIILIIIIVVIIVFKRRRNDSNPSKKENI
...........|...||||..|.|...... ...|. 
iasvavgvvlllvvvivvivlfrrskyskakkdseel
TMEM154 TMEM154 protein family 356-394 9.5e-06 17.0 Pfam-A 68-106 (146) alignment 
Range on Protein: 356-394
Range on HMM: 68-106/146.0
ILIILIIIIVVIIVFKRRRNDSNPSKKENIEDQFQAPLD
. ..|.......|..||.|.  ....... ||. .  ||
LillllvvvilvikkkrkrrKqeetsedekedlqldeld