Gene SpurPTP-sf1-13 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP090_AA protein Get Run
SpurP090_AA_575-850 phosphatase_domain Get Run
SpurP090_AA_862-1025 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 574-1088 0.0 1188.3 In-house 1-515 (515) alignment 
Range on Protein: 574-1088
Range on HMM: 1-515/515.0
PLPLAQFPTFVNKNRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMD
||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKE
||||.|.||||||||||||||||||||||||||.|||||||||.|.|||||||||||||||..|.|||||.|||||||||||||||||||||.|||.|||
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGD
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

GHGRSKMTKEFQTLKSLCPDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIV
|.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstiv

MLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNRVILDSPDHDYINASNMKGVHCTFMTTQMPLPTTVSDFWSMVLNNK
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
mlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskrnrvildspdhdyinasnmkgvhctfmttqmplpttvsdfwsmvlnnk

PSTIVMLNDKSQNDK
|||||||||||||||
pstivmlndksqndk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 573-887 5.6e-184 605.1 In-house 1-315 (315) alignment 
Range on Protein: 573-887
Range on HMM: 1-315/315.0
QPLPLAQFPTFVNKNRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASM
||.|.||||.||||||||.||||||||||.|.||.|.||.|.|||||||||||||.|| |||||||.|.|.|||.|||||.|.|.||||||||||.|||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIK
|||||||.||.||||.||||..||||||| .|||.. .|||.|| |.|||.||||.|.|..| ... |... ||||||.|||||||||.|.||.|||.||
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSG
|||||.|.....|..||||||||||||||||.|||..| ||.|||||||.|.|.||||.|||.|.|||||.|||||||||||||.||||||||||||.|.
evkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsv

DGHGRSKMTKEFQTL
||.|||||||||.||
dgsgrskmtkefetl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 572-889 4e-171 563.7 In-house 1-276 (392) alignment 
Range on Protein: 572-889
Range on HMM: 1-276/392.0
RQPLPLAQFPTFVNKNRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKAS
|||.| ||||.||.||||..||.|||||||||.||||||||.||| ||||||||||||| |||||||.| |.|||.||||||||||.|||||||||| ||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVTTIAMVTKLKEGDkikcgkywpnkpgdsvkfgyirvelvsleactggikrtmtmlKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFI
.|||||||.|||||||||||||||||                                          ||||.|||.||||||||||.||||||.|||||
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

KEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSS
||||||.||||||||||||||||||||||||||||||||.||||||||||||||.||||||||.|||||||||||||||||||||||.|||||||||..|
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

GDGHGRSKMTKEFQTLKS
.||..|||..|||..||.
sdGdvrskqlkefrslka
subfamily_PTPRD_pd Subfamily PTPRD 572-927 2e-123 408.0 In-house 2-358 (564) alignment 
Range on Protein: 572-927
Range on HMM: 2-358/564.0
RQPLPLAQFPTFVNKNR--HTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNK
..|.| |.....|.| .  . . |.||....  ..  . ..|....| .||||.||..||. ||.|. .. .. ||| |||.| .....|||||.||| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpGdSVKFGYIRVELVSLEACTGGIKRTMTMLK--GDDCRTVTQFHFTEWPDKGVPKHTSAL
 ...|||||||..|..|| |.|||.| .| || ||||.| | . ..|.. |.|.. |  .  . ||... |   .. |.|.|||||.|||.|||... .|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQD
|..|..|.| . . ..|...||||||||||. | ||...  .|. ..||....|...|..|..||||.|||.||. |.|| |   || ... ....||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LHSSGDGHGRSKMTKEFQTLKSLCPDPpASQTRSGRTRDNHPKNRYGNNLPLQRNRVILD
|..  .... ... .||| |..  ... ...  ..    |. |||. | |.|...||.|.
LaeveedtemtgleleFqrLatakeie.leefavatkpknkkknrfsnilalescrvvls
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 571-862 2.3e-122 402.8 In-house 6-297 (297) alignment 
Range on Protein: 571-862
Range on HMM: 6-297/297.0
TRQPLPLAQFPTFVNKNRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNdkAYIASQGPNKA
 |.|.||..|.|.|.|||||..|||||..||  ||.|||||.. .||.|.|||||||||| ||||...||.| |||.|||..... .   .|..| |.||
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

SMDDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPNKPgdSVKFGYIRVELVSLEACTGGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPK--HTSA
...|||.||..|.|.||.|.....|.|| || .||..|   ...||.. |.| |.. ..|.|||.... ||.    | | |..|.||||| |..  ..|.
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LLKFIKEVKADHGQYTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFT
|||.|.||. |..| .. ||..||.||||||||...||||||.|| .  ||.|..|. .||.|||.|||.|||.|.| |||| ||  .| |.. .|.
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 589-887 2e-91 301.4 In-house 18-318 (318) alignment 
Range on Protein: 589-887
Range on HMM: 18-318/318.0
HTTLFSEEFHDL-PGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTI
 ..|.|||.. | . ..   .. . |..| .|||| |||.||. ||||. ..... ||| ||.||. . ..|||||.|.|    ..|||||||. | ..|
GelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

AMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADH-GQYTHP
 |.|...|  |.|. .|||.|  .| ..| ..||| .   ..  . |....   . .. |.| |.|.|.|||.|||.... ||.....|.. .  . ..|
vmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGDGHGRSKMTKEF
...||||||||||| | .|... ..|   .||||..|...|..|. ||||..|| ||| ..|| |   .| .   ........|. .    |...|  ||
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaef

QTL
| |
qrl
0051299 (Phosphotyrosine protein) phosphatases II 587-847 1.6e-90 298.7 In-house 19-284 (288) alignment 
Range on Protein: 587-847
Range on HMM: 19-284/288.0
NRHTTLFSEEFHDLPGPNI-YPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVT
 ...|.. |||..|.  .. .....|. . |..||||..|||||. |||| |......||| |||||. .......|| ||| . ...|||||||..||.
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

TIAMVTKLKEGDKIKCGKYWPNkpGDSVKFGYIRVELVSLEACTGGIKRTMTML------KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHG
.| |.||| | ...|| .|||.  |.|...| |.|.|.| | . . ..||...       ... .||||.||.| ||| ||| ....||.|...|.  . 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

QYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.  .| ..||||||||||..| .| .. . .....|||...|  .|..||.|||| ||| |.| |.||
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 573-853 2.1e-90 298.5 In-house 24-303 (308) alignment 
Range on Protein: 573-853
Range on HMM: 24-303/308.0
QPLPLAQFPTFVNKNRHTTLFSEEFHDLPGPNIYPQ-TVAQEEINFKKNRYKNILPYDSVRVKLevindNPHSDYFNASYIPSF--DNDKAYIASQGPNK
 .|.. ..  ...|   ..|..|||..|.   .... .||. . |..|||||.|||||. ||||     ...||| ||||.. .  ......|| ||| .
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlp

ASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPG-DSVKFGYIRVELVSLEACTGGIKRTMTMLK--GDDCRTVTQFHFTEWPDKGVPKHTSA
 ...|||||||..||..| |.||| | ...|| .|||...| .|...|...|.|.| | . . ..||... .  ... ||||.||.| ||| ||| ....
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

LLKFIKEVKADHGQytHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
||.|...|.  ...  .| ..||||||||||..| .| .. . .....||||. |  .|..||.|||| ||| |.| |.|| |... 
lldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 574-883 1e-89 295.7 In-house 13-329 (330) alignment 
Range on Protein: 574-883
Range on HMM: 13-329/330.0
PLPLAQFPTFVNKN--RHTTLFSEEFHDLPGPNIYP-QTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKA
|||. ..   ...     . || |||  ||  .|     .|..| | .|||. ||||||  || | |.. ...||| |||.|  . . . .||.||| . 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

SMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTML-KGDDC-----RTVTQFHFTEWPDKGVPKHT
...|||||.|. . .|| |.|.||| .. || .|||..   .| .| ||||.   . .     | . .  ..| .     | |.||||| ||| ||| ..
tvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

SALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDH
  .||..|.||. . |.. |...||||||||||  | .|.|..  |. |.||||.|| ..|..|| ||||.||| ||| ..||  |. .| . |. .  |
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

LQDLHSSGDGHGRSKMTKE
|| |...  |  .  . .|
lqklynkitgtdkigleee
subfamily_PTPRB_pd Subfamily PTPRB 573-847 1.2e-89 295.2 In-house 5-283 (293) alignment 
Range on Protein: 573-847
Range on HMM: 5-283/293.0
QPLPLAQFPTFVNKN--RHTTLFSEEFHDLPGP-NIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNK
.|. | .| ..|.|.  .  . ||||...|    .   ...|....| .||||.||||||  ||||. ..|...||| ||.||| .   . .||.|||  
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPgDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLK
 ..||||||||......| |.|.| |. |.|| .|||..  ..| .| |.|.||. |  .  . |.... |....|.|.|.||| ||| |||..|..||.
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlld

FIKEVKADH--GQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|...|.  .   . ..|...||||||||||. |..| .. . ... .||.| .|...|..| ..|||..|| ||. .||.
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 572-866 1.4e-88 291.9 In-house 3-296 (315) alignment 
Range on Protein: 572-866
Range on HMM: 3-296/315.0
RQPLPLAQFPTFVNKNRHTT--LFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNK
.||.|| |. |.| ... .|   | ...  .|| ...|  ||..  | .|||| ||..||  ||.| ... .||||| ||..|. ..  . |||.|||| 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpgdSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLK
||..||||.|..|....| |.|.| ||.| |. ||||.|    | .| | | ..| |  |    ||...  ||. |.| |.|.| ||| ||||.| .|..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmn

FIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQ
.|. ||  | .   ....||||||||||  |..|.|. .|.. ...||.||.|..||.|  |||. ||| ||| |.|| ..  .| |    . .. .
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
0040438 (Phosphotyrosine protein) phosphatases II 578-886 1.4e-88 292.6 In-house 6-313 (317) alignment 
Range on Protein: 578-886
Range on HMM: 6-313/317.0
AQFPTFVNKNRHtTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWR
 ..  ...|. . |...|||.||.  .... .||. . | .||||..|||||. |||| ...  ..||| ||||.. ..  ...|| ||| . ...||||
llalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MVWQENVTTIAMVTKLKEGDKIKCGKYWPNkpGDSVKFGYIRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVK
|||...||.| |.|.|.| ...|| .|||.  |.....| ..|.|.| | . | . ||...   .....||||.||.| ||| |||.... ||.|...|.
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

ADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGDGH
.   .  .|...||||||||||..| .. .. . .... |||.. |  .|..||..||| ||| |.| |.|| |....||.|. ..  .|. |.    ..
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

GRSKMTKEFQT
. . ..||...
dvklkekelkl
0046845 (Phosphotyrosine protein) phosphatases II 594-855 4.3e-88 290.6 In-house 3-280 (284) alignment 
Range on Protein: 594-855
Range on HMM: 3-280/284.0
SEEFHDLPGPNIY---PQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDN-PHSDYFNASYIPSF-----DNDKAYIASQGPNKASMDDFWRMVWQENV
 |||. |.  ...   . .||. . |..|||||.|||||. |||| ..... ..|||.||||.. .     .. |..|| ||| . ...|||||||..||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TTIAMVTKLKEGDKIKCGKYWPNKpGDSVKFGYIRVELVSLEACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHG--
..| |.|.| | ...|| .|||.. |.....| ..|.|.| | . . ..||... .   ..  ||||.||.|.||| ||| ... ||.|...|.  .   
rvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

QYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTR---MVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
 . .| ..||||||||||..| .| .  . ....   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 584-854 9.3e-86 282.7 In-house 20-295 (298) alignment 
Range on Protein: 584-854
Range on HMM: 20-295/298.0
VNKNRHTTLFSEEFHDLPGPNI----YPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMV
|.|. . | ...||. |   .       ..||... | ||||| .|...|| || || .... .||| |||.. .... .|.||.|.| .... ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVTTIAMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKAD
..|...|| |.|.|.| ||.|. ||||..   . ..| |.|.| | |  .  |.|.... | .  . |.| |.|||.|||||||......|.....|.| 
teedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

HGQYT-HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
. |   .|.|..|||||||.|  | ||||. ..|. ..||||. |  .|.||| .|||.|||.||| |||| |   |.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 588-885 1.5e-85 282.1 In-house 20-319 (319) alignment 
Range on Protein: 588-885
Range on HMM: 20-319/319.0
RHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTI
  .||. .||..| ...    . |..|.| |||||.|||.||  ||.|  ... . ||| |||.| .... ...|| |.| .  ..|||||||.|.. ..
tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessiv

AMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTML-KGDDC--RTVTQFHFTEWPDKGVPKHTSALLKFIKEVKAD-HGQYTH
 |.|||.|  |.|. ||||..  . ...| . |.| . |   . |.| ...  | ..   |.|..|..|||||..||... .||...|...   ...   
vmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGDGHGRSKMTKE
|...||||||||||  | .| .. . |   ..|||..| ..| .|. |||..||| ||| |.|| .   .| | | .. | |..| .   . | ... .|
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglere

FQ
||
fq
0036941 (Phosphotyrosine protein) phosphatases II 586-860 2.5e-85 281.7 In-house 9-288 (297) alignment 
Range on Protein: 586-860
Range on HMM: 9-288/297.0
KNRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLevinDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVT
..  . | .|  . ||  .... .||. . | .|||||.|||||. ||||    |...|||.||||.. .| ....|| ||| . ...|||||||..|||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEA--CTGGIKRTMTMLK--GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ-
.| |.|.| | ...|| .|||.. |.|...| ..|.|.| |   ... . ||.....  ... ||||.||.| ||| ||| ... ||.||..|.  . . 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-YTHPLIIHCSAGVGRTGVVISIDSVVAHAK---TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIH
   .| ..||||||||.|..| .| ..   .   ... ||....|  .|..|| .||| ||| |.| |.|| |....| .|.. 
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 582-847 2.9e-85 281.3 In-house 3-270 (273) alignment 
Range on Protein: 582-847
Range on HMM: 3-270/273.0
TFVNKNRHTTLFSEEFHDLPGPN-IYPQTVAQEEINFKKNRYKNILPYDSVRVKLevinDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVW
 ...|  ..||. |||..|.    ... .||. . |..|||||.|||||. ||||    ....||| ||||.. ..  ...|| ||| . ...|||||||
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvw

QENVTTIAMVTKLKEGDKIKCGKYWPNKPGD-SVKFGYIRVELVSLEACTGGIKRTMTMLK--GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKAD
..||..| |.|.| | ...|| .|||.. |. |...| ..|.|.| | . . ..||... .   ...||||.||.|.||| ||| ... ||.||..|.  
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

HGQ--YTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. .    .| ..||||||||||..| .| .. . .....|||.. |  .|..||.|||| ||| |.| |.||
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 586-846 4e-85 280.4 In-house 16-276 (288) alignment 
Range on Protein: 586-846
Range on HMM: 16-276/288.0
KNRHTTLFSEEFHDLPG-PNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENV
. |  | ||||.. |.   .   .|....  | |||||.||||||  ||||.  .... .|| ||||| . ...|.|||.|||. ....|||..|.....
sarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

TTIAMVTKLKEGDKIKCGKYWPNKpGDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHP
.||.|.|.| ||.| ||..|||.. .. ...| . |.||. .  .  ..|.. . |  . ...||.... |||.|||. .  ||.... ||  . . | |
stivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgp

LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.|.||||||||||. |..| .. . ... ..||...|...|..|. .|||..|| ||| ..|
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
DSPc_SM00195 607-847 1e-83 276.0 In-house 17-260 (263) alignment 
Range on Protein: 607-847
Range on HMM: 17-260/263.0
PQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. | |... | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .  ..|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

NKPGDSVKFGYIRVELVSLEACT-GGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISID
.. |.. .||.|.|.||. | .    |.||... | .  . |.|||.....|||.|||..|. .|.....|| .. . ..|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 607-847 1e-83 276.0 In-house 17-260 (263) alignment 
Range on Protein: 607-847
Range on HMM: 17-260/263.0
PQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. | |... | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .  ..|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

NKPGDSVKFGYIRVELVSLEACT-GGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISID
.. |.. .||.|.|.||. | .    |.||... | .  . |.|||.....|||.|||..|. .|.....|| .. . ..|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Ptp69D_pd Subfamily Ptp69D 584-868 1.6e-83 275.4 In-house 14-305 (307) alignment 
Range on Protein: 584-868
Range on HMM: 14-305/307.0
VNKNRHT-TLFSEEFHDLPGPNIYPQT-VAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQ
....|.|  .. .|.. |.  .|  .| |.... |  ||||..| ..|. ||||..|| . .||| |||.| .... | .||.|.|  | ..|||||...
ksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae

ENVTTIAMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTMLKGD-------DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEV
 .||.| |...|.| .. || ||||.   | |..| | |.||| | ..  |.|.. . | .       | | |.|.|.|.|.|  ||... .|||.|..|
qevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

KADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDL
.  . .   |...||||||||.|.....||.. . |.   ||.|..| ..|..|. .||  ||| |.| |.|.   . .| . | .. |... |
relyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_PTPRK_pd Subfamily PTPRK 593-886 3.1e-83 274.2 In-house 24-314 (314) alignment 
Range on Protein: 593-886
Range on HMM: 24-314/314.0
FSEEFHDLPGPniypQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTK
| ||.  |.        .|... | .|||...||.||  ||.| .|...|.||| ||..| |. . .|.|. ||| .  . ||||.|..|| ..| |.|.
fkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte

LKEGDKIKCGKYWPNkpgDSVKFGYIRVELVSLEACTGGIKRTMTMLK----GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIH
|.|  ..|| ||||.   |. ..| |.||||. |. .  ..|.... |     .. |.| ||.|. ||| .||..  .|||....||. . .   ....|
lvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGDGHGRSKMTKEFQT
|||| ||||. | ||.|.  ... ..||||| | ..|.... ||.|.||| ||| ..||  |  .| ||| .|     .          |.. .||||
CsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt
subfamily_PTPN12_pd Subfamily PTPN12 604-847 3.7e-83 273.7 In-house 28-275 (290) alignment 
Range on Protein: 604-847
Range on HMM: 28-275/290.0
NIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGK
..|.......| | ||||||.|||||  ||.|. |.....||| ||..|   .....|||.|||  . .||||||.|. ||. . |. .. | .|.|| .
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPNKPGDSVKFGYIRVELVSLEACT-GGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISI
|||.. .....|| ..|.| . .|.. . . ||... . ...|.|.|||.|.|||.|||. .. ||..|..|.  . .  .||..||||||||||..|.|
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| |    |. ..   .|||. |...|..|. .|||.||| ..| ||.|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 575-869 9.6e-83 272.8 In-house 4-303 (305) alignment 
Range on Protein: 575-869
Range on HMM: 4-303/305.0
LPLAQFPTFVNKNRHT--TLFSEEFHDLPGPnIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASM
. |... ......| .  . . .... |.     .  | ..| | .|||.|.| ..|  |..|   .....||| ||||. .... |.||..||| |  .
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKGVPKHTSALLK
.||||....| |.|| |.|||.||.| || .|||.. .....|| . ||| | .. .. |.| ... .    .. |||.|...|.|||.|||. ...||.
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FIKEVKADHGQYTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDL
.||.|. |. .    ||..||||||||||| |..|  . ..|.  .||||. . ..|.||..||||..|| |.. |. | .   .| | .  .. ... |
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

H
.
k
0043336 (Phosphotyrosine protein) phosphatases II 588-847 4.1e-82 271.1 In-house 17-275 (278) alignment 
Range on Protein: 588-847
Range on HMM: 17-275/278.0
RHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTI
   ||...||..|.  .......|. . |..|||||.|||||. ||||....  ..||| ||||.. ..  ...||.|||.. ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLKEGDKIKCGKYWPnkpGDSVKFGYIRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPL
 |.|.|.| ...|| .|||   |.|...| ..|.|.. | . . . ||...   . . .||||..|.. ||| ||| ..| ||.|.|.|.       .|.
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..||||||||||..| .. .. ...... ||... |  .|..|| .|||..|| |.| |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 582-854 4.2e-82 271.2 In-house 23-294 (297) alignment 
Range on Protein: 582-854
Range on HMM: 23-294/297.0
TFVNKNRHTTLFSEEFHDLPGPNIyPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDN-PHSDYFNASYIPSFDN-DKAYIASQGPNKASMDDFWRMV
 ...|   .||. .|| .|.  .. ....|. . | .|||||.|||||. |||| ....  ..||| ||||.. .|  ....||.|||.. ...||||||
lllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WQENVTTIAMVTKLKEGDKiKCGKYWPNKPGdsvKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHG
|...||.| |.|||.| .. || .|||.. |   ..| ..|.|.. | . | . ||... ...  ||||.|..| ||| ||| ... ||.|...|.  . 
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

Q--YTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
.    .| ..||||||||||..| .. .. . .... |||.. |  .|..||..||| .|| |.| |.|| |....|
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 591-849 1.9e-81 268.3 In-house 15-276 (281) alignment 
Range on Protein: 591-849
Range on HMM: 15-276/281.0
TLFSEEFHDLPG-PNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAM
. | ||...|    .  . | .... | .||||.||  ||  |||..  ..| ..|| ||...|.....|.|||.|||  ||...||.|||...|..|.|
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

VTKLKEGDKIKCGKYWPnKPGDSVKFGYIRVELVSLEACTGGIKRTMTM-LKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYT-HPLII
||.  |..|.|| .|||  .  ..|.| ..|. .. |. .  |.|....  .. . |.|.|...| |||.|||. |..||.| |||.  . . | .||.|
vtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||||||||. |..| .| .. ......|| . |...|..| .||||  ||.|.| |||. |
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045450 (Phosphotyrosine protein) phosphatases II 583-847 5e-81 268.1 In-house 19-302 (307) alignment 
Range on Protein: 583-847
Range on HMM: 19-302/307.0
FVNKNRHTTLFSEEFHDLPGPNI---YPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDN-PHSDYFNASYI--------PSFDNDKAYIASQGPNKA
....  . |.. .||..|.  ..   .. ..|. . | .|||||.|||||. |||| ..... ..|||.||||.        ...|.....|| ||| . 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

SMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpGDSVKFGYIRVELVSLEACTGGIKRTMTML---KGDDCRTVTQFHFTEWPDKGVPKHTSAL
...|||||.|...||.| |.|.|.| ...|| .|||.. |... .| ..|.|.| | . | . ||...    . .  ||||.||.|.||| |||.... |
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|.||.||.. ...    .| ..||||||||||..| .. .  . ... .   ||... |  .|..|| .||..||| |.| |.||
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 616-847 5e-80 263.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 616-847
Range on HMM: 1-235/235.0
NFKKNRYKNILPYDSVRVKLeviNDNPH-SDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVK
|.||||||.|||||. ||||   ..... ||| ||.|. .....|..||.||| | ...|||||||||.|..|.|.|.|.| .. || .|||.. ..|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGYIRVELV-SLE-ACTGGIKRTMTMLKGDDC---RTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHA
.| |.|||. . . .... . |.... | ..    |.|.|.|.|.|||.|||.....||..|..|. .. . ..|...||||||||||.....| .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 616-847 5e-80 263.7 In-house 1-235 (235) alignment 
Range on Protein: 616-847
Range on HMM: 1-235/235.0
NFKKNRYKNILPYDSVRVKLeviNDNPH-SDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVK
|.||||||.|||||. ||||   ..... ||| ||.|. .....|..||.||| | ...|||||||||.|..|.|.|.|.| .. || .|||.. ..|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGYIRVELV-SLE-ACTGGIKRTMTMLKGDDC---RTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHA
.| |.|||. . . .... . |.... | ..    |.|.|.|.|.|||.|||.....||..|..|. .. . ..|...||||||||||.....| .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 609-849 8e-80 262.6 In-house 2-242 (250) alignment 
Range on Protein: 609-849
Range on HMM: 2-242/250.0
TVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIkCGKYWPNK
.||..  | .|||| .|...|| || ||  . . .||| |||.. ..|. ||.||.||| .|.. ||||||..|...|| |.|.||| .|  . .||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

pgDSVKFGYIRVELVSLEACTGGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVISIDSV
   . |.| ..|.| | |  .  .||.. . |    | |.| |.||. |||||||... | |...|.|.| . |  . |.|..|||||||.|  | ||.|
..kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
. ..|. ..||||...  .|..|| .|...||| |.| ..|. |
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 587-884 4.7e-76 251.0 In-house 19-323 (325) alignment 
Range on Protein: 587-884
Range on HMM: 19-323/325.0
NRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMV--WQenv
 .    |. ||  ||  .   ..||    | .|||.||....|  || ||  .|.|.|||.||||. .. . . ..|.| |. |...|.||.|  |.   
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

TTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTM--LKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYT
... .|.   ...| .| .|||.. |.|..|| ..|.|...|  .  ..| . .   |. . |.| ||..  |.| ||.|. ..|. ... ||| . . |
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

H------PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGDGHG
       |...||||||||||| ||. |..|.  .   ||.|.|| ..|..|| ||.| .|| .|| |. | ..  || .||  |  .|  |.       
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltq

RSKMTKEF
. .. |||
klniekef
0040439 (Phosphotyrosine protein) phosphatases II 607-847 5.4e-75 247.5 In-house 2-244 (249) alignment 
Range on Protein: 607-847
Range on HMM: 2-244/249.0
PQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
. .||. . | .||||..|||||. ||||..... ..||| |||||. ..  ...|| ||| . ...|||||.|....|.| |.|.|.| ...|| .|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NkpGDSVKFGYIRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVISI
.  |.|...| ..|.|.| | . . . ||...   . .. |||.....| ||| |||.... ||.||..|.  . .    .|...||||||||||..| .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. .. . .... ||... |  .|..||..||..||| |.| |.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 592-853 7.6e-75 247.2 In-house 20-291 (563) alignment 
Range on Protein: 592-853
Range on HMM: 20-291/563.0
LFSEEFHDLPG---PNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHS-DYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTI
 |||||..|     ..  . . .|.. | .|||| ||..||. ||||. . .. .. || ||.||  .   ||.||.||| |  .||||||.|..||..|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTKLKEGDKIKCGKYWPNkpGDSVKFGYIRVELVSLEACTGGIKRTMTMLK-----GD---DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHG
 |.|.|.|  . ||  |||.   .|...| ..| |.. |  .   .||... .     ..   . ..|.|.|.|.|||.|||.|.   |.|.|  .| . 
vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

QYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
. . |...||||||||||. | .|...   ..  .|.||.|.  || .|...|||.||| |.. |.|| .. ..
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_PTPN6_pd Subfamily PTPN6 589-846 1.2e-73 242.8 In-house 24-294 (306) alignment 
Range on Protein: 589-846
Range on HMM: 24-294/306.0
HTTLFSEEFHDLP---GPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEvINDNPHSDYFNASYIP--SFDNDKAYIASQGPNKASMDDFWRMVWQEN
. . |.|||..|      . . .. ..   | .|||||||||.|  ||.|.  .. | ||| ||.||   . ..||.|||.||  .. . ||||||||||
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

VTTIAMVTKLKEGDKIKCGKYWPNKPGDSVkFGYIRVELVSLEACTGGIKRTMTML---KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ
 . | |.||  |  | || .|||..  ..  .| |.|. || .. .  | |....    |....|.| |.||..|||.||||...|.|.|...|.. . .
srvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

YT----HPLIIHCSAGVGRTGVVISIDSVVAHAKT---TRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
 .     |...|||||.|||| .| || ..   ..      .|. ..|  .|. |  .|||..|| |.| |. 
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0042113 (Phosphotyrosine protein) phosphatases II 610-847 1.7e-72 239.1 In-house 3-241 (245) alignment 
Range on Protein: 610-847
Range on HMM: 3-241/245.0
VAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNkp
||. . | .||||..|||||. |||| ... ...||| ||||.. ..  . .||.||| . . .|||||.|....||| |.|.. | ...|| .|||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GDSVKFGYIRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHG-QYTHPLIIHCSAGVGRTGVVISIDSVV
|.|...| ..|.|.| | . . . ||...   . |  |.|...|.. ||| ||| ... ||.|...|.        .|...||||||||||..| .. ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

AHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 ...... |.... |  .|..|| .|||..|| |.| |.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 593-870 4.2e-72 238.1 In-house 36-312 (319) alignment 
Range on Protein: 593-870
Range on HMM: 36-312/319.0
FSEEFHDLP--GPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMV
.  ||. ..  |.|   || |  . |  |||. |||..|  .|||| ..    ||| |||..  . . . |||.||| . ...|||||.|. |..|| ..
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TklkegdKIKCGKYWPNKPGDSVKFGYIRVELVSleACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ--YTHPL
|      | || .|||.|     . . ..|..|    .   . | . . .     | | .|||||  |||.|||...| |....| |.  . .    ...
t......kdkcsqywplkivikeerfkvkvdsve..etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhrani

IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHS
..||||||||||| | .| ..   |  ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| .
vvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
subfamily_PTPN9_pd Subfamily PTPN9 582-847 8.2e-72 236.7 In-house 8-288 (297) alignment 
Range on Protein: 582-847
Range on HMM: 8-288/297.0
TFVNKNRHTTLfSEEFHDLPGPNIYP-QTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVW
..|.....  | |.|. ..   ..    ....   | .||||...| ||. ||.|. ......||| ||...  . . ||.|| ||| |  ..|||||||
ayvkekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

QENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADH
...| .| |.|.. |  ..|||.|||.. ..| .|| ..|. |. |      .|....   | .. |.|| | |. ||| |||. ...||.....|.   
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

GQYT-------------HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.. .              |...|||||.||||  |..|  ... ... .|||.. |  .|..| ...||.|||.| | ||||
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0045098 (Phosphotyrosine protein) phosphatases II 592-851 1.2e-71 236.6 In-house 9-274 (278) alignment 
Range on Protein: 592-851
Range on HMM: 9-274/278.0
LFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKlevindnphsDYFNASYIPSFdnDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVT
|..| .. |. ....  |.|. . |..|||||.|||||. |||          || |||||...  .|..|| ||| .  ..|||||.|....|.| |.|
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

KLKEGDKIKCGKYWPNkpGDSVKFGYIRVELVSLEACTGGIKRTMTML------KGDDCRTVTQFHFTEWPDKGVPKHT--SALLKFIKEVKADHGQ---
.|.|....|| .|||.  |.|. .| ..|.|.| | .   ..||...       ... .|.||..|.. ||| ||| ..  . .|........ . .   
elvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

----------YTHPLIIHCSAGVGRTGVVISIDSVVAHAktTRMVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLEDLLW
            .| ..||||||||||... .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 602-870 6e-71 234.2 In-house 11-276 (284) alignment 
Range on Protein: 602-870
Range on HMM: 11-276/284.0
GPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTklkegdKIKC
|.|   || |  . |  |||. .||..|  .|||| .  .  ||| |||.|  . . . |||.||| . ...|||||.|. |..|| ..|      | ||
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

GKYWPNKPGDSVKFGYIRVELVSleACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ--YTHPLIIHCSAGVGRT
 .|||.|     . . ..|..|.   .   . | . . .     | |...||||  |||.|||...| |....| |.  . .    .....|||||||||
sqywplkivikeerfkvkvdsve..eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHS
|| | .| ..   |  ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| .
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 611-847 1.6e-70 232.0 In-house 2-238 (239) alignment 
Range on Protein: 611-847
Range on HMM: 2-238/239.0
AQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDN-DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKp
|.. .|  |||| ||. ||  || || ....||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | || .|||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

gdSVKFGYIRVELVSLEACTGGIKRTMTMLK--GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVA
  . |.  .|| |   |  .  | ||. | .    . | | |.||| |||||||....|.| . ...  |    ..| .||||||||||| .. ||... 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||  . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 611-847 2e-70 231.7 In-house 3-239 (239) alignment 
Range on Protein: 611-847
Range on HMM: 3-239/239.0
AQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDN-DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKp
|.. .|  |||| ||. ||  || || ....||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | || .|||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

gdSVKFGYIRVELVSLEACTGGIKRTMTMLK--GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVA
  . |.  .|| |   |  .  | ||. | .    . | | |.||| |||||||....|.| . ...  |    ..| .||||||||||| .. ||... 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||  . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 610-847 1.9e-69 228.7 In-house 14-262 (270) alignment 
Range on Protein: 610-847
Range on HMM: 14-262/270.0
VAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFD-NDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNK
. .   . | |||..|||    ||.|| ....... |.|| |.. || ..|.|||..|| .... .||||.|.|.||.|.|.|.|.|  . || .|||..
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

PGD--SVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTS------ALLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGV
|..  ....| |.|  .| |  .| |.. ... .  . | .. |....|||.|||...        ||| ...|.. . .    .||..||||||||||.
pkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

VISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.| .| .|   ..|. ||| . ....|..|. .||. |||.|.| ||.|
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 591-846 5.5e-68 224.0 In-house 5-265 (274) alignment 
Range on Protein: 591-846
Range on HMM: 5-265/274.0
TLFSEEFHDLPGpNIyPQTVAQEEINFKKNRYKNILPYDSVRVKLEV-INDNPHSDYFNASYIPSFDN-DKAYIASQGPNKASMDDFWRMVWQENVTTIA
. . .|| .||  |  .|   .   . .|||||.||| .  || ||   .... |.| || ||  .|. .|||.| |||    ..|||||..||.|. | 
kdlekeflelPl.nf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTKLKEGDKIKCGKYWPNKPGD--SVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTH---
|.||||| .. || .|.|.. .   | ..| . .. ..   . .   |......  ..|.|. . .|.|||. .|.....||....||. .. . ..   
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakla

PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
| ..|||||.||||. |.|.  | . . . .|||.. |.|.|..|  ||||.||| .|. |. 
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 617-847 4.1e-67 220.9 In-house 4-237 (237) alignment 
Range on Protein: 617-847
Range on HMM: 4-237/237.0
FKKNRYKNILPYDSVRVKLEVINDNphSDYFNASYIPSFDN-DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpGDSVKF
  |||| ||  ||  || |.    .  ||| ||.|. .||   | |||.||| ..| ||||.|||||. . | |.| | ||...|| ||||.   .   .
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaay

GYIRVELVSLEACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEV--KADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAK
| . | |   |. .    |.... |     . | . |..|| |||.|||..|.|||.| |..  .. | . . | ||||||||||||... ||... .||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
  ..||..|.| .| . |||..||..|| ||. ..||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0037934 (Phosphotyrosine protein) phosphatases II 609-847 8.4e-67 220.5 In-house 3-240 (243) alignment 
Range on Protein: 609-847
Range on HMM: 3-240/243.0
TVAQEEINFKKNRYKNILPYDSVRVKLevinDNphSDYFNASYIPSFDNdkaYIASQGPNKASMDD----FWRMVWQENVTTIAMVTKLKEGDKIKCGKY
..|. . | .||||..|||||  ||||    ..  |||.||..|. ...   .||.||| . . .|    ||||.|....|.| |.|.|.| ...|| .|
siallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPnkpgDSVKFGYIRVELVSLEACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKAD----------HGQytHPLIIHCSA
||    ..| .| ..|.|.| | . . . ||...     .| .|.|...|.. ||| ||| ... ||.|..||..           ...  .|...||||
wp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsa

GVGRTGVVISIDSVVAHAkttRmVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLE
||||||..| .. .  .    . ||... |  .|..||. .|||..|| |.| |.||
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN13_pd Subfamily PTPN13 595-849 1e-66 220.0 In-house 15-269 (273) alignment 
Range on Protein: 595-849
Range on HMM: 15-269/273.0
EEFHDLPGPNIY-PQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDnphsdYFNASYIP--SFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVT
|||..|         .|.... | .||||.|.||||  ||||.         | |||.|     ..   |||.|||   ...|||.|||. ... |||||
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLKEGDKIKCGKYWPNKPGDSVKFGY-IRVELVSLEACTGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGqYTHPLIIH
. ||..|.|| .|||.. ....|    ..|||. ..   |   |....   .  . | |....|..||| |||...  ||.|..||.  .   . |...|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||.||.|..|.|| |.   .  . .|| . | ..|..|  .|||..|| |.| |.|| |
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN3_pd Subfamily PTPN3 609-847 3.3e-66 218.1 In-house 34-273 (280) alignment 
Range on Protein: 609-847
Range on HMM: 34-273/280.0
TVAQEEINFKKNRYKNILPYDSVRVKLEvinDNPHsDYFNASY----IPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKY
..|.   | .||||..|||||. ||||.   ...  || ||.|    ||| .  . |||.||| . .. |||.|||......| |.| | |  ..|| .|
saarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPNkPGDSVKFGYIRVELVSLEACTGGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISI
||. ..|....| ..|.. . .. .  . | ... . .  . |...|. ...|||.|||.... .|.|...|.. .   ..|...|||||.|||||.| .
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.  .|   ... | . . | ..|..|  .|||..|| |.  |.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 892-1028 2e-65 215.7 In-house 29-173 (315) alignment 
Range on Protein: 892-1028
Range on HMM: 29-173/315.0
PDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-S
|||.....|..|...|..||||.|.|||...||.|    ||||.||||||..|....  .....|.||...|.|||.|||..|..||||...|...|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPD--ANSVQFGSYSVSTLSTSSDGDMTIRQLqVTRNSKRNR
|.|||||  |.||.|||..|..||...|.|...|.| |||.|.  |
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 576-848 2.5e-65 215.2 In-house 3-282 (290) alignment 
Range on Protein: 576-848
Range on HMM: 3-282/290.0
PLAQFPTFVNKN--RHTTLFSEEFHDLP-GPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPH--SDYFNASYIPSFDNDKAYIASQGPNKA
|. .|  || ..  . .. | ..|. |  | . .  ||.  . | ..||..||..||  |. |  |....    .| ||.||  . ..|.||| ||| . 
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

SMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDD---CRTVTQFHFTEWPDKG-VPKHTSA
 . |||...|||.|| | |.|. .| .| || .|||..  |. ..|.....|.. |.... |.|.. . . .    ...|||...| |...| |..... 
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
|| . . .|  . .  .....|||..|||..| ....  . ..||.  .|||. . . |...| .|||..|| .|.  ||. 
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 578-850 3.5e-64 211.5 In-house 5-279 (287) alignment 
Range on Protein: 578-850
Range on HMM: 5-279/287.0
AQFPTFVNKNRH--TTLFSEEFHDLPGPNIYP--QTVAQEEINFKKNRYKNILPYDSVRVKLEvindNPHSDYFNASYIPSFDNDKAYIASQGPNKASMD
 .|  ||.|...   . |.. |  |   .  .   |..  . | .|||...||..|  || |.    . | || ||..| .. ..||.|....|    . 
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntar

DFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTMLK---GDDCRTVTQFHFTEWPDKG-VPKHTSALLK
.||......|||.| |....|| |. .| .|||..  .|| .|  ..||.. |  .| |.|.. . .    .| ..|.|...|.|...| |... . || 
nfWkliddrnvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

FIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
. . .|... .   ....|||..|||... ....  . ..||   .|||. . . |...| .||| ||| ||. .||| | 
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPN23_pd Subfamily PTPN23 610-848 1.9e-63 209.0 In-house 37-279 (288) alignment 
Range on Protein: 610-848
Range on HMM: 37-279/288.0
VAQEEINFKKNRYKNILPYDSVRVKLEvindNPHSDYFNASYIPSFDND-KAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNK
.|  ... .|||...|||||. ||||.    . . || |||.. .       .||.|.| . .. |||.||... . .| |... .| .| |. .|||..
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

PGDSVKFGYIRVELVSLEACTGGIKRTM--TMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKA----DHGQYTHPLIIHCSAGVGRTGVVISI
 |..|||| ..| | | .     ..|..  ..|. |  ..|.  ..|.||. |||.  . ||.|..||..     . .   ||..|||||||||||.  .
kgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 ..|.   |   ..|. . |  .|..| .|||..||. | | |||| 
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 587-858 4.8e-59 194.6 In-house 5-275 (283) alignment 
Range on Protein: 587-858
Range on HMM: 5-275/283.0
NRHTTLFSEEFHDLPGPNIyPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDnphsDYFNASYIP---SFDNDKAYIASQGPNKASMDDFWRMVWQEN
.    || | .. |  |.  . ..|  . | .|||...|.|.|  ||.|.  .     || ||..||   | ..|| ||..|.| .  . |||.||..|.
vnnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

VTTIAMVTKLKEGDKIKCGKYWPNKpgDSVKFGYIRVELVSLEACTGGIKRTMTMLKG---DDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ
.|.| |.|||.|. .||| .|||..   |...|   | |    .    |.. ... .     .   .. . . .| . |      .|.|| | .     .
itaivmltklqedlrikCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

YTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPV
   |...|||.|.|||.| |.. . | .|.|  .||||. |...|..|. .|||..|| ... .|||. |  .| |  
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_PTPRN_pd Subfamily PTPRN 608-848 8.4e-59 193.7 In-house 48-291 (297) alignment 
Range on Protein: 608-848
Range on HMM: 48-291/297.0
QTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDN-DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
..||..| | ||||.|..||||  ||||.  ... .||| ||| |   |    ||||.|||  ... |||.|||.. |. | ..|.|.| .  .| .|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

NKpGDSVkFGYIRVELVSLEA-CTGGIKRTM--TMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISID
.. | .| ..   |.|||    |   . |..    |. .. ||||||||  ||..|||  . .||.| . |   .   . |...|||.|.||||| | ||
de.Gsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SVVAH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 |... .|  . .|.   .  .|..|| .|.|..|. |...|| |.
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN14_pd Subfamily PTPN14 609-847 1.5e-58 193.1 In-house 42-294 (300) alignment 
Range on Protein: 609-847
Range on HMM: 42-294/300.0
TVAQEEINFKKNRYKNILPYDSVRVKLEVINDNpHSDYFNASYIPS--FDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWP
..|. . | .|||.|..|||. .||.|   ..| ...| ||| |      ... ||..||| .  . |||.|||...|. |.|.|. .|. | |. ||.|
staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

NK--PGDSVKFGYIRVE--LVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKA--DHGQY-------THPLIIHCSAGV
..    ..|.||  .|   ...   ..  .. ..  |   . |||  . .|.|||.|||.  .  |....||..   . .          |...||||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

GRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|||||.|  | ..|  .. . .|. . .. .|..| ..|||  || |.| ....
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 585-862 2.6e-58 192.5 In-house 15-292 (439) alignment 
Range on Protein: 585-862
Range on HMM: 15-292/439.0
NKNRHtTLFSEEFHDLPG--PN-IYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQ
.||..  .|.|.|. .    |.     ..| .| .  |||||.. ..|  || |. |   ||| |.|| ||  . .|| |||.|||.| . |||||.|..
dknkq.eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

ENVTTIAMVTKLKEGDKikcgkYWPNKpgDSVKFGYIRVELV---SL-EACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVK-A
....|| |.|.| |  |     ||| .  . | .| | |       | . .  |.|      ...  ||| |||.. |||| || ..| .|.|.. .. |
kktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa

DHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFT
.  . . |...|||||||||| .|..|  . . |.   ||.   |. .|..|  |||.  || ||| |||||. . .. . . .| 
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
subfamily_CG7180_pd Subfamily CG7180 587-850 7.2e-58 190.5 In-house 13-291 (296) alignment 
Range on Protein: 587-850
Range on HMM: 13-291/296.0
NRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTT
...  ..  |..  |  .|     . .. | .|||. ...|||  || || .. . .||| ||.|. ||  .|.||  ..| | ..|.|||.|..|.. .
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

IAMVTKLKEGDKiKCGKYWPNKPgdSVKFGYIRVELVSLEACTGGIKRTMTMLKG------------DDCRTVTQFHFTEWPD-KGVPKHTSALLKFIKE
. ..||  .  | .. .|||||     ..| | ||.|. .  .   .||. . |              . |.|..|..|||.  . ||  |.||..... 
vvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VKADHGQY-----THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
|.   ..      . |.....| |..|.|| ..||  .  .. .  ||||..|  .|..|| .|.. |.| .||  .|| .|
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 587-848 4.7e-56 184.7 In-house 11-292 (301) alignment 
Range on Protein: 587-848
Range on HMM: 11-292/301.0
NRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVIN--DNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENV
. |.. |.|....|   .  . ||  .| | . ||.||| .||  |. |.  .  |  . .| ||||| .. . |..||.||| |  . ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLE-----------------ACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSAL
..| |||.|||| | || .||||   .| .|| . |.||.                   .  | |.|.. . .  . ..|.|.. |.||. || .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFIKEV-KADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
|. | .| .. .     |...|||..|.|.|| .|..  .  .|    ||||. .  .|...| .|.| ||| .|| .. . 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_PTPN1_pd Subfamily PTPN1 605-848 1.4e-55 183.1 In-house 21-270 (290) alignment 
Range on Protein: 605-848
Range on HMM: 21-270/290.0
IYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDnphsDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKY
 .|...|... | ..|||... |||  |.|||  .     || ||| .   . .. || .|||    .| ||.|||...  .. |. |. | ..||| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPNKPG-DSVKFG--YIRVELVSLEACTGGIKRTMTM--LKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADH--GQYTHPLIIHCSAGVGRTG
||..   .....    ..|.|.| |     . |.. .  || ...|....||.| ||| |||.  .|.|||. .|.      .   | .||||||.||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 .. .|..... . .     ||. . . ..|. |  ..||..|  | | |.|| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 610-846 3.9e-52 171.8 In-house 32-274 (287) alignment 
Range on Protein: 610-846
Range on HMM: 32-274/287.0
VAQEEINFKKNRYKNILPYDSVRVKLeVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKp
 |.|  . ||||| ..||.|  || | . . .  ||| || |..|. .|.|.||.|||  |.. ||||.|...........|.  |  . || ||||.. 
aaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.

GDSVKFGYIRVELVSLEACTG-GIKRTMTM--LKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEV-----KADHGQYTHPLIIHCSAGVGRTGVVIS
   .. |   | |.. .        |.. .  |.. ..| | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|....
evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.  .|   . .  ||| . |  .|..|  .||.  |. ..| |. 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0051429 (Phosphotyrosine protein) phosphatases II 642-848 8.8e-48 158.6 In-house 2-224 (272) alignment 
Range on Protein: 642-848
Range on HMM: 2-224/272.0
PHSDYFNASYIPSFDN---DKAYIASQGPNKASMDDFWRMvWQENVTTIAMVTKLKEGDKIKCGKYWP----------NKPGDSVKFGYIRVELVSLEAC
| |.|.||.... . .   ......|.|| ... .||||. ......|| ..... | .. || .|||          .    .. .|..|| |.| | .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TGGIKRTMTML---KGDDCRTVTQFHFTEWPDKGVPKHTsaLLKFIKEVKAdhgqyTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVD--------V
.  | |....    . .. |.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ...    . .||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
...|  .|..||..|||.|||.|.| |.|| 
eeaveelraqrpgavqteeqylflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 616-857 5.7e-45 148.5 In-house 1-179 (182) alignment 
Range on Protein: 616-857
Range on HMM: 1-179/182.0
NFKKNRYKNILPYDSVRvklevindnpHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTklkegdkikCGKYWPNKPgdsvkf
|..||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|         .  |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gyirvelvsleactggikrtmtmlkgddCRTVTQFHFTEWPDKGVPKhTSALLKFIKEVKAdhgqYTHPLIIHCSAGVGRTGVVISIDSVVAHakttrMV
                             |...|.... ||| |||  .. ||.||.||..      .| ..||||||||||... .. .  .      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIP
.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 593-846 1.3e-44 147.0 In-house 13-266 (281) alignment 
Range on Protein: 593-846
Range on HMM: 13-266/281.0
FSEEFHDLPG-PNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEV-INDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMV
| .|| .||| |     || .. .| ||||| ||   |  ||.|.| . ..  .||  | || |    . || .|||.| .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADhgqyTHPLIIHCS
 .. | .. || .|.| .    ..|  . |.          .   . .    . | .|.. . ||||  ||. .  .|| .....|     . | .||||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRTGVVISIDSVVAHAKT-TRMVDVFNFVTNIRQ-KRPYMVQTQEQYAFIYGAVL
|||||.| .....  .   ..   . |. . |. .|   |   ||| .|| .|.  .|
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
0036282 (Phosphotyrosine protein) phosphatases II 644-842 8.3e-44 144.7 In-house 2-163 (174) alignment 
Range on Protein: 644-842
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNDKAYIASQGPNKasmddFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNkpgdsvkfgyirvelvsleactggikrtmtmLKGDD
|||.|||..  .   . .||.||| .     ||.|......||. |....|| .. ||  |||                                |. | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

CRTVTQFHFTEWPDKGVPKHTSaLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVISIDSVVAHAKtTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 |.. |.... ||| |||  .  ||.|.|.|.  . .   .|...||||||||||... .. .  . . ...||....|  .|..||.||||..|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 880-1030 1e-43 144.6 In-house 23-179 (297) alignment 
Range on Protein: 880-1030
Range on HMM: 23-179/297.0
MTKEFQTLKSLCPdpPASQTRSGRTRD---NHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTI
.  .. . . ||.  |....... . .   | .|.|| | || ...||.|    |.|| ||.||| .||..  ..||||| ..|| ||| |||....|||
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNS-KRNRVI
|||||....||.||.||.|  ...||. || .||.|.   .  |.|.||... | .||.
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 595-850 1.4e-43 144.1 In-house 20-278 (307) alignment 
Range on Protein: 595-850
Range on HMM: 20-278/307.0
EEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVinDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLK
.||. |   .    ||   . | .||||...   |  |. ...  |   |||  | |.    . | .|..||| .... .|| |. ||.| .. |. |. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EGDKIKCGKYWPNKPGDSVKFGYI----RVELVSLEAC---TGGIKR-TMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADhgqyTHPLI
|  |||| .||| . |.   ||       |. .  .        |.  |. .  ....||.... ...|||.|||.   . . ... |. |    | |..
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvv

IHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
.||||||||.| ...|  |     .     |. ..| ..|..|.| .||. || ...  .|| .|
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0050432 (Phosphotyrosine protein) phosphatases II 844-1022 7.4e-42 139.1 In-house 7-190 (308) alignment 
Range on Protein: 844-1022
Range on HMM: 7-190/308.0
AVLEDLLWRNTLIPVIHFTDHLQDLHS-SGDGHGRSKMTKEFQTLKSLCPdppASQTRSGRTRDNHPKNRYGNNLPLQRNRVILdSPDHDYINASQMKGI
|.|| ||.|.| |.|.... ...||.    . ...... .||..| |..|     ......  .|..|||| . ||. ..||.| ....|||||| ..| 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgy

----HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND-KSCAQYWPDA---NSVQFGSYSVSTLSTSSDGDMTIRQLQVTR
     ..|  || |||.|| ||| || ... ..||||..  .|. . ||||||.    .|...| ..| .||. ...|.|.|.|..| 
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltn
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 609-846 1e-41 137.5 In-house 49-280 (290) alignment 
Range on Protein: 609-846
Range on HMM: 49-280/290.0
TVAQEEINFKKNRYKNILPYDSVRVkleVINDNPHSDYFNASYIPSFdnDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNK
 . ... .|||||||..   |  ||   ...|  . ||  | |.     .  .| .||. |... |.|||| ||.|..| |. .| |  | || .|.|.|
kifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

PGDSVKFGYIRVELVSL-EACTGGIKRTMTMLKGDDCRT--VTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGqythPLIIHCSAGVGRTGVVISIDSV
 |. . || | |      .  .  ||.|... . |. .   .  ..   |||| |.. | |||. .. ..   |    |...|||||.||||  ..|.  
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievg

VAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.      . .|. . |  .|. |   || . ||  .  ..|
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
0051299 (Phosphotyrosine protein) phosphatases II 853-1023 1.8e-40 134.6 In-house 2-172 (288) alignment 
Range on Protein: 853-1023
Range on HMM: 2-172/288.0
NTLIPVIHFTDHLQDLHssgdGHGRSKMTKEFQTLKSLCPDppaSQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--IHCTF
.| |.| ....... |.     .| ... .||..| ||.||    ......   |..|||| . ||. ..||.| .    ...|||||| ..|  . ..|
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

MTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND-KSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
. || |||.||.||| || ... ..||||..   .. . ||||||. .|...| ..| .||. ...|.|.|.|.||..
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 615-847 2.2e-39 130.0 In-house 47-285 (305) alignment 
Range on Protein: 615-847
Range on HMM: 47-285/305.0
INFKKNRYKNILPYDSVRVKLEviNDNPHsDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVK
 . .|||||..   |  |||||  .  || .|  | |. .  | | .| .| | . .  ||| | .|..| .| |. .|.|    || .|.. | .| ..
qeagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FGY----IRVELVSL------EACTGGIKRTMTMLKGD--DCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGqythPLIIHCSAGVGRTGVVISI
|      | | . |       . .   ...|. ...|   . | ||..|. .|||.|||    |.|..... .. .|    |...|||||.|||| |. .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvml

DSVVAHAKTTRMVDV-FNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
. ..    . ....     .  ||..|   .||..|| |..  .|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0043147 (Phosphotyrosine protein) phosphatases II 642-842 1.3e-38 127.7 In-house 3-154 (172) alignment 
Range on Protein: 642-842
Range on HMM: 3-154/172.0
PHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLkegdkikcgkywpnkpgdsvkfgyirvelvsleactggikrtmTMLKG
..||| ||||..     . .|| |||    ..|||||......|.| ..|.|                                           . .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

DDCRTVTQFHFTEWPDKGVPkHTSALLKFIKEVKA-DHGQYTHPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPYMVQTQEQYAF
. .|.. |.... ||| ||| ... ||.|.. ..   . .  .| ..||||||||||... .. .       . ..... |  .|.|||..||...|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IY
.|
ly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 613-850 1.4e-38 127.3 In-house 52-290 (305) alignment 
Range on Protein: 613-850
Range on HMM: 52-290/305.0
EEINFKKNRYKNILPYDSVRVKLEvinDNPHSDYFNASYIPS-FDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGD
 .|.  ||||...   |   |||.   . . |||  | |.   .  .| .|..|||   ..|.|| || |..|  | |. |  |  |.|| .|||   |.
adiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

SVKF-GYIRVELVSLEAC---TGGIKRTMTML--KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHgqytHPLIIHCSAGVGRTGVVISIDSV
 ... . | || ||          |. |.  |   ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyi

VAH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
. . |.  .   . ..|  .|..| . .|.. || ||.  .|. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
0047943 (Phosphotyrosine protein) phosphatases II 874-1022 3.2e-38 127.1 In-house 8-159 (273) alignment 
Range on Protein: 874-1022
Range on HMM: 8-159/273.0
GHGRSKMTKEFQTLKSLCPdppASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPST
  |.... .||..|.||.|      .. ..  .|. |||| . ||. ..||.|.....|||||| ..|  .  .|. ||.||| || ||| || ... ..
llgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLNDKSQNDK-SCAQYWPDAN---SVQFGSYSVSTLSTSSDGDMTIRQLQVTR
||||..  ....  ||||||. .   |...| ..| .||. ...|.|.|.|..|.
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltn
0049772 (Phosphotyrosine protein) phosphatases II 608-851 1.5e-37 125.4 In-house 38-282 (314) alignment 
Range on Protein: 608-851
Range on HMM: 38-282/314.0
QTVAQEEINFKKNRYKNILPYDsVRVKLEVINDNPhSDYFNASYIPSFdndKAYIASQGPNKASMDDF----------WRMV--WQENVTTIAM------
 .||. . | .||||..|||.|  ||.|   . .  |||.||||. .|   ...||.|||..  ..||          ||||  .. || .| |      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------VTKLKEGDkikcgkywpNKPgDSVKFGYIRvelvsleactggikrtM-TMLKGDDCRTVTQFHFTEWPDKGVP--KHTSALLKFI
                ..| ..          | | .   . ...                  .  . .  |.. ... . .|| ..|  ..  ..|.||
adelsrLdaAlgKtpllildgng.........nep.taadlellk................eelydpelferlgikylripvpDgsaplledfdeflefi

KEVkadhgQYTHPLIIHCSAGVGRTG--VVISIdsVVAHAkttRMvDVFNFVTNIRQKRP-----YMVQTQEQYAFIYGAVLEDLLW
.|.     .  .|...||.||.||||  ||. .  .. .    .. ..   .  .|.|||      .....||| ||. |.|| | .
eea.....dkggpvlvHCkaGkgRtgtfvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
0039614 (Phosphotyrosine protein) phosphatases II 875-1025 1.9e-37 124.8 In-house 29-181 (297) alignment 
Range on Protein: 875-1025
Range on HMM: 29-181/297.0
HGRSKMTKEFQTLKSLCPDppasqTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSMVLN
 ..... .||..|.|| ||     .. ..   | .|||| . ||. ..||.| .     .|.|||||| ..| ..   .|  || ||| || ||| || .
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

NKPSTIVMLNDKSQNDKSCAQYWPDANSvQFGSYSVSTLSTSSDGDMTIRQLQVTRNSK
.. ..||||..   ... ||||||.  . ..| ..| .|..  ....|.|.| ||.|..
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnge
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 616-844 2e-37 123.7 In-house 33-254 (267) alignment 
Range on Protein: 616-844
Range on HMM: 33-254/267.0
NFKKNRYKNILPYDSVRVKLEVINDNphsdYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEgDKIKcgKYWPNKPGDSVKF
| ..||. . ||||  || |   ...    | ||||. ..   .|.|. |.| | .. ||. .. ...|..| ..||  . |.|.  ..|| | |.. |.
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dnir..lfwPPkmgqakky

GYIRVELvSLEACTGG--IKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSA-LLKFIkeVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT
  . ||  |||       |      .| . .. || ... .|  .   |     |.  .   | .  .  .||...||.||||.|  . ||| .  ||| 
qdltveh.slekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
 ..|.|.|. .||..|. .|.|.|.| .|.  
gvsdifdflrkirsqriglvdtkeryiyihel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 856-1028 2.3e-37 123.8 In-house 5-184 (298) alignment 
Range on Protein: 856-1028
Range on HMM: 5-184/298.0
IPVIHFTDHLQDLHSSGDGHGRSKMTKEFQTLKSLCPDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIHC--TFMTT
| . ... .|| | .    .. .....|||.|.|   . .. ... .|...|. |||| . ..|.  ||.| .     . |||||| ... .   .|..|
ieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiat

QMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNR
| ||..||.||| || ... .|||||..  . ||  . .|||| .. ..|. .|| ||. . .|...|.|.|........
qaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeeke
0046845 (Phosphotyrosine protein) phosphatases II 880-1023 2.5e-37 124.2 In-house 2-158 (284) alignment 
Range on Protein: 880-1023
Range on HMM: 2-158/284.0
MTKEFQTLKSLCPDPPaSQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGI-------HCTFMTTQMPLPTTVSDFWSMVLNN
. .||..| || ...   ... ..   |. |||| . ||. ..||.|.|     .|.|||||| ..|        ...|. ||.|||.|| ||| ||...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTIVMLNDKSQNDK-SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
. ..||||..  .|..  ||||||. . ....| ..| .||.  ..|.|.| |..|..
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl
0049260 (Phosphotyrosine protein) phosphatases II 652-842 3.6e-37 122.7 In-house 2-143 (152) alignment 
Range on Protein: 652-842
Range on HMM: 2-143/152.0
IPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWpnkpgdsvkfgyirvelvsleactggikrtmtmlkgddcrtvtQFH
|. . . ...|| |||   ...|||||... ..||| |.|.| | .|.|| .|.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.. ||| |||...  || ... ..    .  .| ..||||||||||... .. .       . |.....|  .|.|||..|....|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0046846 (Phosphotyrosine protein) phosphatases II 637-845 5.3e-37 122.6 In-house 5-169 (176) alignment 
Range on Protein: 637-845
Range on HMM: 5-169/176.0
VINDNPHSDYFNASYIPSFdndkAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNkpgdSVKFGYirvelvsleactggikrtm
.. .....|| ||..| .     ..|| |||   .. ||..|......|.. ..|...| ...||  |||       |.|.                   
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...................

tmlkgddcrtvtQFHFTEWPDKGVPKHtSALLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVISIDsvvaHAKTTRMVDVFNFVTNIRQKRP-YMVQTQ
            |.... ||| ||| . ..||.......    .  .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..|||.
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYAFIYGAV
||| |.| ..
eQyrflyefe
0036941 (Phosphotyrosine protein) phosphatases II 876-1022 6.2e-37 122.9 In-house 11-161 (297) alignment 
Range on Protein: 876-1022
Range on HMM: 11-161/297.0
GRSKMTKEFQTLkslCPDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIV
..... |||..|   .|  .   .. ..  .| .|||| . ||. ..||.||....|||||| ..| .   .|. || |||.|| ||| ||.... ..||
flalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSS--DGDMTIRQLQVTR
||..  ....  ||||||.   .|...| ..| .||...  ..|.|.|.|.|| 
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 612-772 8.9e-37 121.5 In-house 29-191 (297) alignment 
Range on Protein: 612-772
Range on HMM: 29-191/297.0
QEEINFKKNRYKNILPYDSVRVKLEviNDNPHSDYFNASYI--PSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKP
. .  ..||||..|| .|. ||||   .  . .|| || |.  |  ..|  || .||| .|..||||..|....| .|.||.||.|. . ||  |||.  
krnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

GDSVKFGYIRVELVSLEACT--GGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIK
..  | | . || .|  .      |   ....  .. | |.   |  |||.|||     | .|  
qerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
DSPc_SM00195 880-1025 2e-36 121.0 In-house 2-154 (263) alignment 
Range on Protein: 880-1025
Range on HMM: 2-154/263.0
MTKEFQTLKSLCPDPpasQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIV
. .||..|..  ..    .|....   |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| ||...| ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLQVTRNSK
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|.|..| . |
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk
PTPc_SM00194 880-1025 2e-36 121.0 In-house 2-154 (263) alignment 
Range on Protein: 880-1025
Range on HMM: 2-154/263.0
MTKEFQTLKSLCPDPpasQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIV
. .||..|..  ..    .|....   |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| ||...| ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLQVTRNSK
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|.|..| . |
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk
0040438 (Phosphotyrosine protein) phosphatases II 860-1023 5.7e-36 119.8 In-house 4-166 (317) alignment 
Range on Protein: 860-1023
Range on HMM: 4-166/317.0
HFTDHLQDLHSSGDghgrSKMTKEFQTLKSLCPDppasQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGI--HCTFMTTQMPL
.. ..|.||. |.      .. .||..| || .|     .. ..  .|..|||| . ||. ..||.| ..    |.|||||| ..|     .|  || ||
dlllalldllksdf....talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl

PTTVSDFWSMVLNNKPSTIVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
| || ||| || ... ..||||..  .. .. ||||||. .....| ..| .||.  ....|.|.|.|. .
pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 603-852 6.6e-36 118.8 In-house 29-274 (288) alignment 
Range on Protein: 603-852
Range on HMM: 29-274/288.0
PNIYPQTVAQEEI-NFKKNRYKNILPYDSVRVKLEvinDNPHSdYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKC
||  .. .... | |  ..||.|.   |  ||||.   |.|.  | .|  ..|  ...  | .| | .. .. .|.|. ...|  | |...| |  | | 
pneasidiidsfianptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks

GKYWPNKPGDSVKFGYIrVELVSLEActGGIKRTMTM--L----KGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVkadhGQYTHPLIIHCSAGVGR
 .|.| | |.....| .    |  .    .|......  |    .|..   | . |. ||.|.|||.   . |.... .     ....|...|.||||||
aeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGr

TGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWR
|| .| |  ..  .. .  . . ..... |..|   .||. || ...  |||.|| .
tgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_ptpA1_pd Subfamily ptpA1 613-801 1.2e-35 118.1 In-house 44-248 (418) alignment 
Range on Protein: 613-801
Range on HMM: 44-248/418.0
EEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSfDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDS
.. |  |||| |||| .  ||.|. |.|.  ||| || ||      | .|..|||   .. |||||||.. .  | |...  |  .||| .|||.. |  
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

---------VKFGYIRVELVSL--EACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQY------THPLIIHCSAGVGR
           ||   |||| .  .     | | . .    . | .||...  |||. .| ||  . .... .   . |         |.|.||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGVVIS
|| . .
tgtfct
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 738-885 4.8e-35 115.7 In-house 82-230 (440) alignment 
Range on Protein: 738-885
Range on HMM: 82-230/440.0
MLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQE
...| ..||. |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||.|..||.. .|| .  .|.|.|. ..|..|| |||| |
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHSSGDGHGRSKMTKEFQ
||||.. |||| ||  .|||     |.......       .| . .||.
qyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 610-849 1e-34 114.8 In-house 29-270 (285) alignment 
Range on Protein: 610-849
Range on HMM: 29-270/285.0
VAQEEINFKKNRYKNILPYDSVRVKLEvindNPHSDYFNASYIPSFDND-KAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNK
 .  | |   ||| ..   .  || |.    |   ||  ||..    .|  .||..|||   .. |||.|..||... . |.  | ||   ||  |.|.|
ytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

PGDSVKFGYIRVELVS--LEACTGGIKRTMTMLKGDDCRTV----TQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQyTHPLIIHCSAGVGRTGVVISI
 |. ||||   . |     || .| |  ..|... .|. .      . .   |||.  |. .  .... | ||    .  .|. .|||||||||  .. |
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgi

DSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
|    .      ..... | ..|  |   ||.. |. |.|  ..| .
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0045450 (Phosphotyrosine protein) phosphatases II 876-1023 1.5e-34 115.5 In-house 25-188 (307) alignment 
Range on Protein: 876-1023
Range on HMM: 25-188/307.0
GRSKMTKEFQTLKSLCPDPpASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKG----------IHCTFMTTQMPLPTTVSDF
..... |||..|.|.....    .....   |..|||| . ||. ..||.| |     .|.|||||| ..           .  .|. || ||| || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSMVLNNKPSTIVMLNDKSQNDKS-CAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLQVTRN
| |. ... ..||||..   ...  ||||||| ... ..| . | .||.. ....|.|.| ||..
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl
0043336 (Phosphotyrosine protein) phosphatases II 874-1024 2.3e-34 114.6 In-house 16-168 (278) alignment 
Range on Protein: 874-1024
Range on HMM: 16-168/278.0
GHGRSKMTKEFQTLKSLCPdppaSQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSMVLNN
  ..... .||..| |  .      .. ..  .|..|||| . ||. ..||.|.. .    .|||||| ..|     .|  || ||| || ||| || ..
lnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

KPSTIVMLNDKSQND-KSCAQYWPdANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNS
. .|||||..   .. . ||||||  .|...| ..| .|.. ...|.|.|.| ||.. 
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlg
0051082 (Phosphotyrosine protein) phosphatases II 642-845 2.5e-34 113.4 In-house 1-149 (151) alignment 
Range on Protein: 642-845
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdndkaYIASQGPnkasMDDFWRMVWQENVTTIAMVTKLKEGDkiKCGKYWPNKPgdsvkfgyirvelvsleactggikrtmtmlkg
|.|||.|.||. ..     ...|.||    ..||..........|| ......| .  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ddcRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKAdhgQYTHPLIIHCSAGVGRTGVVISIDSVVAHakttrmVDVFNFVTNIRQKRPYMVQTQEQYAFI
   ..|...... ||| |.| .. |.|.|.... .   .  .|...|||||.||||... .. .  .      |...  .  .|.|||..||. .|. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YGAV
. |.
lfal
0044763 (Phosphotyrosine protein) phosphatases II 627-844 4.9e-34 112.9 In-house 1-166 (178) alignment 
Range on Protein: 627-844
Range on HMM: 1-166/178.0
PYDSVRVKLEVINDNPHSDYFNASYIPSFdndkAYIASQGPnkasmDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGdsvkfgyirvelvsle
|.|  ||.|. . . . |||.|||.|  .     |..|..|      |..........|.| ..|. .|. ..|| .||| . |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

actggikrtmtmlkgddcrtvTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHakttRMvDVFNFVTNIRQ
                      |.... .|| |||  .. .|.|.. ... . .  .| ..||||||||.|... .. .  .    .. .... .  .|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

KRPyMVQTQEQYAFIYGA
.|| .|....|. ..|  
rRp.ivpnpgqlrqLyef
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 892-995 4.9e-34 112.4 In-house 30-148 (392) alignment 
Range on Protein: 892-995
Range on HMM: 30-148/392.0
PDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND-----KSQ
|.|.......... .| .||||.|.||....||.|    |.||.||.|||.......  .....|.| .....|||.||......||.|...     | .
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

NDKSCAQY----WPDANSV
.....||.    |||..  
dartvaqfhftewPdkdvp
PTPc_DSPc_SM00012 746-847 3.2e-33 109.4 In-house 1-105 (105) alignment 
Range on Protein: 746-847
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
||...|.|.|||.|||......|.....||  . . .  .|...||||||||||... .| .. . ... . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 873-1028 7.2e-33 108.9 In-house 16-176 (288) alignment 
Range on Protein: 873-1028
Range on HMM: 16-176/288.0
DGHGRSKMTKEFQTLKSLCPdppASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLN
. ..|. ...|...| .|      ...  ||   |..|||| | ||.  .|| |.     .. |||||| ..| .   ....|| ||. || ||| .| .
sarnrtgfseeynsLaalek...tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

NKPSTIVMLNDK-SQNDKSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNR
|| ||||||..   .... | .|||||.  ...||  |  ...   .|.. |.| . .. .. .
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkktele
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 618-844 6e-32 105.6 In-house 52-277 (301) alignment 
Range on Protein: 618-844
Range on HMM: 52-277/301.0
KKNRYKNIlPYDSvRVKLEVINDNPHSdYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGY
.|.||... | .     .|||.|        | .||.  . . .||.||| |....||| |. | .| .|.|...  |  . || .| | |...... | 
dkhryptv.PckP.stavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

IRVELVSLEACTGG--IKRTMTMLKG---DDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADhgqyTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT
 ...... |       .|||. .       . |||| . ..||.|.||||    | .... ||       .|...|||||.||.   |. . .  . .. 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarevead

RMVDVFNFVTNIRQKRPYMVQTQEQYAFI-YGA
. ... . . ..|..|   |||..|  ..  |.
ptieltealkhlrehrwngvqtnsqlywmtlGt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 902-1030 6.7e-32 105.6 In-house 4-138 (250) alignment 
Range on Protein: 902-1030
Range on HMM: 4-138/250.0
GRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDKSCAQYWPDANSV
..  .|. |||| . ..|.  ||.| . .     |||||| ..| .   .|..|| ||..|. ||| |||..| .|||||.. ....| . ||||  .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

QFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNRVI
..|.  || ||.   .|.|.|.|......| ...|
kyGdvtvsllskeefadytkrklklskakkaderi
subfamily_PTPRD_pd Subfamily PTPRD 895-1026 8.5e-32 105.5 In-house 36-173 (564) alignment 
Range on Protein: 895-1026
Range on HMM: 36-173/564.0
PASQTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQ
. ..... .   | .|||| | ..  ..||.|      .. |||||| ..| .   ... || ||..|..||| || ... ||||||.  . ..|  |..
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVtRNSKR
|||. .. ..|.. |.  ..    |..||.... ...|.
YWPekgtetygeltVtleeeeeladyeirtfkl.kkkks
0045098 (Phosphotyrosine protein) phosphatases II 892-1022 1.1e-31 105.7 In-house 18-143 (278) alignment 
Range on Protein: 892-1022
Range on HMM: 18-143/278.0
PDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVIldspdhDYINASQMKGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN-DKSCAQYWP
. .. |.   .  ..| .|||| . ||. ..||.      |||||| ..| . .|  || |||.||.||| |. ... ..||||..  ..  . ||||||
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

DANSVQFGSYSVSTLSTSSDGDMTIRQLQVTR
. .|...| ..| .||..  .|.|.| | || 
eggsltygdftvtllseevlddytlrtllvtn
Y_phosphatase Protein-tyrosine phosphatase 907-1025 1.6e-31 104.9 Pfam-A 1-128 (235) alignment 
Range on Protein: 907-1025
Range on HMM: 1-128/235.0
NHPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWP--DANSVQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||...| ..||||..  . ... ||||||  . .|...|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSTL-STS-SDGDMTIRQLQVTRNSK
..| .  ...  . ..|.|.|... . .
ikvelkekekedekeytlrklelkkkke
Y_phosphatase Protein-tyrosine phosphatase 907-1025 1.6e-31 104.9 In-house 1-128 (235) alignment 
Range on Protein: 907-1025
Range on HMM: 1-128/235.0
NHPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWP--DANSVQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||...| ..||||..  . ... ||||||  . .|...|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSTL-STS-SDGDMTIRQLQVTRNSK
..| .  ...  . ..|.|.|... . .
ikvelkekekedekeytlrklelkkkke
subfamily_PTPRB_pd Subfamily PTPRB 856-1029 1.9e-31 104.2 In-house 7-181 (293) alignment 
Range on Protein: 856-1029
Range on HMM: 7-181/293.0
IPVIHFTDHLQDLHSSGDghgrSKMTKEFQTLKSLCPDPPASqtrSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTT
| . .|..|......  |     ....|...||..  |   .   . ..  |. |||| | || . .|| |    |... |||||. ..| ..   |..|
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqavk...aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNRV
| |||.|| ||| ||...| |.|||| .   . |  | .|||.  ..|..|. .|. .....  | .||.|..........|
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 856-1026 2.5e-31 103.9 In-house 2-172 (318) alignment 
Range on Protein: 856-1026
Range on HMM: 2-172/318.0
IPVIHFTDHLQDLHSsgdgHGRSKMTKEFQTLKSlCPDPpASQTRSgRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGIH--CTFMTT
|.| .. .|.. |..    .|. ....|.. |.  ...  .....|  .  |. |||| | |. .. || |.    ... |||||. . | .   ... .
isvedleshvrrlre....sGelllseeyerlsr.seet.vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKR
| ||| |..||| || . . ..|||| ....   . ...|||. .| ..|.  |   .. . .|...|...|||. . 
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee
subfamily_PTPN6_pd Subfamily PTPN6 862-1028 4.4e-31 103.0 In-house 10-186 (306) alignment 
Range on Protein: 862-1028
Range on HMM: 10-186/306.0
TDHLQDLHSSGDGHGRSKMTKEFQTLKSLCPDPPASQtRSGRTRDNHPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMK----GIHCTFMTTQMPLP
 .. ..|. ...  ... ...||..|.        |. . |.  .|. |||| | ||   .||||   . |..|||||...|    | ......||  |.
eqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

TTVSDFWSMVLNNKPSTIVMLNDKSQN-DKSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLQVTRN--SKRNR
|||||||.||....   |||.  .     . ||.||||...  ..|..||...| .|  | ..|.|.|...  .|..|
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeer
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 616-842 1.4e-30 101.0 In-house 52-283 (310) alignment 
Range on Protein: 616-842
Range on HMM: 52-283/310.0
NFKKNRYKNILPYDSVRVKLEvINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpGDSVKF
...|||| ...  |. ||||. |.   . ||  | |. .    ...| |||| . .. |||||..||   .| .. |  |  . ||  |||   | .  .
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtety

GYIRVELVS-----LEACTGGIKRTMTMLKGDDC------RTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGqythPLIIHCSAGVGRTGVVISIDS
| |||  .|     .| |   .      .  |.         |.  .. .|||.|||      .      .  ||    | ..|||||..|..||.... 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalkl

VVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 . ...    ||. . .|.....|   .||. || .| 
kidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 853-1024 2.2e-30 100.8 In-house 2-172 (319) alignment 
Range on Protein: 853-1024
Range on HMM: 2-172/319.0
NTLIPVIHFTDHLQDLHSsgdgHGRSKMTKEFQTLKSLCPDppasQTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTF
.| |.| .. ..|. |.|     |  .. |||..||   .|    ...|  . .|..|||| | |. .| ||.|    .... |||||| . | .    |
dteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekf

MTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNS
. || || .|..||| || ... |..|||.. ... |  . .|||..| ...| . |  ..     |. ||.|.. ..|
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkks
subfamily_PTPN23_pd Subfamily PTPN23 875-1024 2.7e-30 100.2 In-house 12-166 (288) alignment 
Range on Protein: 875-1024
Range on HMM: 12-166/288.0
HGRSKMTKEFQTLKSLCPDPpASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSMVLNNKPST
.|.... |.|. |..      | ..     . .  |||. . ||  .||| |..   |||||| .|..     .|..|| ||..|..|||.|| ..| |.
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNS
|||| .|.. .| ....||| .  ..|.|| .||.  |. . . .  |.|... ..
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld
subfamily_egg_pd Subfamily egg 608-846 4.1e-30 99.5 In-house 32-267 (307) alignment 
Range on Protein: 608-846
Range on HMM: 32-267/307.0
QTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDkiKCGKYWPN
 | | .. | .| | | .   || |||||. .     |.  | ..        .| .| | | ..|||||||.||.|  | |.|  || .  .|  |||.
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpk

KPGDSVKF--GYIRVELVSLEACTGGIKRtMTMLK--GDDcrtVTQFHFTEWpdKGVPKHTSALLKFIKeVKADHGQYTHPLIIHCSAGVGRTGVVISID
 . ||...  | .|.| . ..  .  . | .| ||  | |     . .   |  .|  ...| .   .. |     . ..| ....  || .......|.
aesdslvtvpGslrienlkvdskadplfr.vtklklvGgd...deerflehw..qgdvnnssdvysplr.vlrklrnlskpvvvqdilGvskaatlvaie

SVVAHAK--TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  . .     .    | . |  .|..|.. |..  .| |.|  ||
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0040439 (Phosphotyrosine protein) phosphatases II 903-1023 4.3e-30 100.5 In-house 7-134 (249) alignment 
Range on Protein: 903-1023
Range on HMM: 7-134/249.0
RTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN-DKSCAQYWPDANSV
.   |..|||| . ||. ..||.| .    ...|||||| ..|  |  .|  || ||| ||.||| |. ... ..||||..  ..  . ||||||. .|.
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

QFGSYSVSTLSTSSDGDMTIRQLQVTRN
..| ..| .||. . .|.|.|.|..|..
eygdftvtllsvevkddytvrtleltnl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 864-1025 3.8e-29 96.6 In-house 6-168 (287) alignment 
Range on Protein: 864-1025
Range on HMM: 6-168/287.0
HLQDLHSSGDGHGRSKMTKEFQTLKSLCPDPpASQTrSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFW
.. ..  .|  .|.   .. |..|...  ..  . |  . . .|..|||. . |. . .||.|   ..|||||. ..| .    |. .. |.  |. .||
kfgefvakghakgnegfknqftvleqvtqre.devt.hniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

SMVLNNKPSTIVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSK
 .. ......|||| .. .| .. | ||||. .|| .| |... |.     ....|.|.|....|
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknk
0042113 (Phosphotyrosine protein) phosphatases II 903-1023 4.5e-29 97.0 In-house 5-132 (245) alignment 
Range on Protein: 903-1023
Range on HMM: 5-132/245.0
RTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDANSV
.   |..|||| . ||. ..||.| ...    .|||||| ..|     .|  || ||| || ||| |. ... .|||||..   ...  ||||||. .|.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

QFGSYSVSTLSTSSDGDMTIRQLQVTRN
..| ..| .||. ...|.|.|.|.||..
tygdftvtllseehlddytvrtlevtnl
subfamily_PTPRG_pd Subfamily PTPRG 856-1023 4.9e-29 96.0 In-house 1-171 (563) alignment 
Range on Protein: 856-1023
Range on HMM: 1-171/563.0
IPVIHFTDHLQDLHSSGDghgrSKMTKEFQTLKSLCPDPpASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS-PD----HDYINASQMKGIH--CTFMT
.|| .|. |. .||..||     ....||. |.| . .    .. . . ..|. |||| | .. .| || | . |.    .|||||. ..| .    |..
vpvkefakhvaslhadgd....igfseefealqsetisk.dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQMPLPTTVSDFWSMVLNNKPSTIVMLND-KSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
|| ||..|. ||| |. ... ..|||. . . .. . | .|||  .|...|. .|   ..      |.|.|..   
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknl
subfamily_Ptp69D_pd Subfamily Ptp69D 879-1026 4.9e-29 96.4 In-house 23-174 (307) alignment 
Range on Protein: 879-1026
Range on HMM: 23-174/307.0
KMTKEFQTLKSLcpdPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTI
 ..||...|..        .|. .   .|  |||| .  .  ..||.|       | |||||| .||   . .|.. | |. .|. ||| |. . .  .|
glakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLNDKSQNDK-SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKR
||| . .. ..  ||.|||. . ||.|.  | . |... .| .||.|.|... . 
vmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkee
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 855-1026 7.3e-29 95.5 In-house 1-174 (290) alignment 
Range on Protein: 855-1026
Range on HMM: 1-174/290.0
LIPVIHFTDHLQdlhsSGDGHGRSKMTKEFQTLKSlcpDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPD--HDYINASQMKGI--HCTF
|||| .|.....     |  .|.... ..|..|.|        ..  | | .|...||. | .. . ||..|      .|  ..||||. .||   .  .
lipvdkfgefva....nghakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy

MTTQMPLPTTVSDFWSMVLNNKPSTIVMLND-KSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKR
. || |.. |. |||... ..| . |||| . .... . | |||||... ..| .|.  |. ..  ....|.|.|. ... 
iatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa
0037934 (Phosphotyrosine protein) phosphatases II 905-1022 3.6e-28 94.2 In-house 8-125 (243) alignment 
Range on Protein: 905-1022
Range on HMM: 8-125/243.0
RDNHPKNRYGNNLPLQRNRVILdsPDHDYINASQMKGIHcTFMTTQMPLPTTVSD----FWSMVLNNKPSTIVMLNDKS-QNDKSCAQYWPdaNSVQFGS
  |..|||| . ||. ..||.|  ...|||||. ...   ..  ||.||| || |    || |. ... ..||||..    . . ||||||  ..|..| 
penlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygd

YSVSTLSTSSDGDMTIRQLQVTR
..| .||... .|.|.| |....
ftvtllseehlddytvrtlllen
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 891-1025 3.8e-28 93.5 In-house 33-174 (325) alignment 
Range on Protein: 891-1025
Range on HMM: 33-174/325.0
CPDPPASQTRSGrTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDKS
 .| . ... ..   .|  |||. | ..|...||.|    |.|. |||||| ..      .|...|.||..|. |.| .||. . | .|.||   .....
psddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdr

CAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSK
||.|||.   .|..||.  |.  .     |   |.|.| . .|
cavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1025-1088 4.1e-28 93.1 In-house 57-126 (315) alignment 
Range on Protein: 1025-1088
Range on HMM: 57-126/315.0
KRNRVIL----DSPDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK
...||.|    ||||.|||||| .|.|..  .....|.||...|.|||.|||..|..||||...|...||
dsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 887-1028 9.5e-28 92.2 In-house 28-178 (305) alignment 
Range on Protein: 887-1028
Range on HMM: 28-178/305.0
LKSLCPDppASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN-DKS
 |||. .   ...  |..  |. |||. .. .|. .|.||      .|.|||||| ..| .   .....| ||..||.||| .... |.||||||   . 
ykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

QNDKSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLQVTR--NSKRNR
.... | ||||.. .   .||..||   |...  | ..|.|...   ..| .|
ggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesr
subfamily_PTPN12_pd Subfamily PTPN12 875-1028 4.5e-27 89.7 In-house 5-171 (290) alignment 
Range on Protein: 875-1028
Range on HMM: 5-171/290.0
HGRSKMTKEFQTLKSLCPDPPASQ---TRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGI--HCTFMTTQMPLPTTVSDFWSMVL
.|. ...||||.||.|     |..   | .|..  |  |||| . || . .|| |     ... |||||. .||   ..... .| |||.|..||| |. 
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

NNKPSTIVMLNDKSQNDK-SCAQYWPDA--NSVQFGSYSVSTLSTSS-DGDMTIRQLQVTRNSKRNR
. . . .||.  .  ..|  |..|||.   ....||...|.. .    | |..||.|.|........
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 619-856 5.4e-27 89.7 In-house 22-257 (290) alignment 
Range on Protein: 619-856
Range on HMM: 22-257/290.0
KNRYKNILPYDsVRVKLEVINDNPHSDYFNASYIpSFDNDKAYIASQGPNKAS-------MDDFWRMVWQENVTTIAMVTKLKEGDKI----KCGKYWPN
..|... |  .  || |..      .||. |... .. |. . |..| | ..        . .|| |. ||.|. . |. . .| ..      | || |.
dqRlevpLvea.trvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KPGDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDD-CRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKadhgQYTHPLIIHCSAGVGRTGVVISIDSVV
. |...||. . |.  | |.  . ..|....  .|.   |||   . .| .  |...|  ||. |. ||    ... | |.||  |. |  .. .|.   
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

AH-AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLedllwrntlI
   |.|.  | . . . ..|..|  ........||.  ...         .
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........l
subfamily_CG42327_pd Subfamily CG42327 594-777 8.7e-27 88.6 In-house 8-193 (319) alignment 
Range on Protein: 594-777
Range on HMM: 8-193/319.0
SEEFHDLPgpNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSFDND-KAYIASQGPNKASMDDFWRMVWQENVTTIAMVTK
 |||.|||  ..  .. .      .|.|. |..|    || |. | |.... |..|||.  .|.    |||.| . . |  ||||.||. .  .|  .|.
aeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LKEGDKIKCGKYWPNKPGD--SVKFGYIRVELVSLEACTGGIKRTMTM--LKGDDCRTVTQFHFtEWPDKGVPKHTSALLKFIKEVKAD
| |    .| .|.| | .      .| |.| |   |.    .  |. .  .... .| .| . . .|.. .|| . .||.  . ||.. 
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_PTPRK_pd Subfamily PTPRK 903-1026 9.5e-27 88.6 In-house 39-168 (314) alignment 
Range on Protein: 903-1026
Range on HMM: 39-168/314.0
RTRDNHPKNRYGNNLPLQRNRVILDSPDHD----YINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND-KSCAQYWPDANSV
.  .|. |||.|. |.  | ||.| . | |    ||||. . . .    |. || ||. || ||| .|.... ..||||..  ..    | .|||.  .|
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

qFGSYSVSTLSTSSDGDMTIRQLQVTRNSKR
 .|   |  ..|. . .. .| ..|.. .. 
.ygdikvelvetellaelvvrifrveklarg
subfamily_PTPRA_pd Subfamily PTPRA 897-1025 4.4e-26 86.5 In-house 48-183 (330) alignment 
Range on Protein: 897-1025
Range on HMM: 48-183/330.0
SQTRSGRTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND-KSQNDKSCAQYW
.        .|. |||. | || . .||||      .. |||||| ..| .   .|...| |.  || ||| |. . | .||||| . | .... |||||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSK
||  .| .|   |.   .    |.|.|.. |.. ..
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 895-1029 1.2e-25 84.9 In-house 21-162 (283) alignment 
Range on Protein: 895-1029
Range on HMM: 21-162/283.0
PASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK-----GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKS-QNDKSCAQY
|  ..    ...|..|||. . .| ...|| |.|  .|||||. .           .. .| ||  || ||| || ..| ..||||     .... |.||
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN-SKRNRV
||   |...| . |.     .   ..|..| .  | | .. .
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstl
subfamily_PTPN9_pd Subfamily PTPN9 866-1025 1.5e-25 84.9 In-house 4-169 (297) alignment 
Range on Protein: 866-1025
Range on HMM: 4-169/297.0
QDLHSSGDGHGRSKMTKEFQTLKSlcpDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGI--HCTFMTTQMPLPTTVSD
..| .    .|.. ..||.. ...    |.. .    ..| |  |||| . | ... || | .       |||||. . |   . .|..|| ||. ||||
eelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWP--DANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSK
|| || ...  .|||     .. .  |.||||  . .| .||..|||.... .  | ..|.|....  .
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt
subfamily_PTPN3_pd Subfamily PTPN3 895-1029 2.5e-25 84.0 In-house 29-172 (280) alignment 
Range on Protein: 895-1029
Range on HMM: 29-172/280.0
PASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK------GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQ
|  ..   |  .| .|||| . ||    ||.|.. . |||||. ..      |.   ...|| ||..|..||| || ..| |.|||| .  .. .  | |
pglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNS-KRNRV
|||.  .....|..||   .....  . .|.| ..... |..| 
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 900-1028 2.6e-25 84.0 In-house 42-176 (315) alignment 
Range on Protein: 900-1028
Range on HMM: 42-176/315.0
RSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDKSCAQ-YWPDA
.  .   |. |||| | ..  . || |      |. ||.||. ..|      ....| |....| ||| .| ... ..||||..  ...|. |. |||| 
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

nSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNR
  | .| ..|.  |     ..|.| | |. ... . 
.kviyGkitvtrkseevnteytvrtlsvvfgdnire
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 616-846 6.9e-25 82.1 In-house 51-282 (302) alignment 
Range on Protein: 616-846
Range on HMM: 51-282/302.0
NFKKNRYKNILPYDSVRVKLEVINDnphsDYFNASYI--PSFDndKAYIASQGPNKASM---DDFWRMVWQENVTTIAMVTKLKEGDKiKCGKYWPNKPG
| |||. ...  .|| .||||  .|    .| ||| .  |..   .  | .| |.. |    ..|||||.||..... .. . .| .|    ...|.| |
nlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRT---VTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVA
| ...| ..|     |   .  .| .  .  ..|     ..  ..| |..| ||.. ..| | ...| | . . .....|    |.|| |....   .| 
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
. ..   . . . |..||..|| .|.. .||...| |.|
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 879-1030 1.9e-24 81.2 In-house 16-172 (281) alignment 
Range on Protein: 879-1030
Range on HMM: 16-172/281.0
KMTKEFQTLKSLCPDPPASQTrsgRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTI
 ...|...|...  | .|. .   .. .|  |||| |       || .    .. . |||||. ..|..    ...|| |.|... .|| ||...| |.|
Gfieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLNDKSQNDK-SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNRVI
||.  . ...|  | .|||| | ....| . |.......   .  |.....|.|  .| .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetrev
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 604-850 2.2e-24 80.7 In-house 30-277 (312) alignment 
Range on Protein: 604-850
Range on HMM: 30-277/312.0
NIYPQTVAQEEINFKK-NRYKNILPYDSVRVKLEviNDNphSDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCG
||....     ..||  ||| ||  .|  |  |    |.    |  | ..    . . ....||| . .   ||...     |.| ... . |    || 
nivsdsectaflkfkdlnrypniqcwdrgrftla..gde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekca

KYWpnkpGDSVKFGYIRVELVSLEACT----GGI---KRTMTMLK------GDDCrTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHgqytHPLIIHC
||      | | |  .    |  | ||    ||    | |  .||      |..   . .. .. |||.|.|    . |...  || |.    .|.| ||
kyi....sdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahc

SAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
|||||||| .. |.|..|  .  |  .| .    .|. |   |..  || .   .||| | 
sagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 878-1026 1.4e-23 78.7 In-house 34-181 (319) alignment 
Range on Protein: 878-1026
Range on HMM: 34-181/319.0
SKMTKEFQTLKSLCPdPPASQTRSgRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPST
.|.  ||. .  | . . | || .    .|  |||..| |.  .|.| |.  .     |||||| ..|      ....| ||. |. ||| |. . . ||
tklevefrracklgv.nladqtfa.nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLNdksqnDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKR
||.|       . |.||||    .. . . |.  |     . ..|........| 
ivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgke
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 665-847 2e-23 77.3 In-house 97-286 (302) alignment 
Range on Protein: 665-847
Range on HMM: 97-286/302.0
QGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTGG--IKRTMTM---------LKGDDCRTVTQFHFT
  | | ... .| .. | ||. .. .....|... || .|. .| |. .|||   |. ||..        |.....          | .  .||  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

EWPDKGVPKHTSALLKFIKEVKAdhgqYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 |||.| ||.. . |. .|  ..    | . ...|||||||||| ...|   .   .. .. |. . |. .|| |   ||...|  ..   |  
awpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_PTPN1_pd Subfamily PTPN1 898-1022 2.4e-23 77.3 In-house 23-155 (290) alignment 
Range on Protein: 898-1022
Range on HMM: 23-155/290.0
QTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINAS--QMKGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWPDA--
.||. ..  |...||| .  | .  |..|.. | ||||||  ... ..  .. || ||| ||. || || ..|  ..||||   . .   ||||||    
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-NSVQFG--SYSVSTLSTSSDGDMTIRQLQVTR
 .....   ...|  .|. .    |.|.|... 
ekellledtklkvkliseerksyytvrllelen
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 658-842 5.8e-23 76.1 In-house 4-197 (199) alignment 
Range on Protein: 658-842
Range on HMM: 4-197/199.0
DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTG----GIKRTMTMLKGDDCRTVTQFHFT
.. |||.| | . .| |||.|||.     | ||   .   .     |||     . |.| . |   .. .        .  |         | .... ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsALLKFI---KEVKADHGQY-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 | .|  |. .  .. |.   .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0048076 (Phosphotyrosine protein) phosphatases II 704-845 6e-23 76.5 In-house 2-139 (145) alignment 
Range on Protein: 704-845
Range on HMM: 2-139/145.0
YWPNKPGDSVKFGYIRVELVSLEACTGGIKR--TMTMLKGDDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVIS
|||..  ... .| . . |   . .  ||..  ..|. . .  |...|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||... 
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDSVVAhakttRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAV
.. .       . |.... .  .|..||..|....|. |.| ..
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 902-1026 6.5e-23 76.6 In-house 20-145 (284) alignment 
Range on Protein: 902-1026
Range on HMM: 20-145/284.0
GRTRDNHPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNdksqnDKSCAQYWPDANSV
    .|  |||.|. |.  .|.| |.  .     |||||| ..|      ...|| ||. |. ||| |. . . ||||.|      .. |.||||    .
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivi

QFGSYSVSTLSTSSDGDMTIRQLQVTRNSKR
. . . |.  | .   ....|........| 
keerfkvkvdsveeseeyvvrdielsedgke
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 658-842 9.8e-23 75.4 In-house 3-196 (198) alignment 
Range on Protein: 658-842
Range on HMM: 3-196/198.0
DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSLEACTG----GIKRTMTMLKGDDCRTVTQFHFT
.. |||.| | . .. |||.|||.     | ||   .   .     |||     . |.| . |   .. .        .  |         | .... ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsALLKFI---KEVKADHGQY-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 | .|  |. .  .. |.   .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 906-1028 1.1e-22 75.5 In-house 27-162 (274) alignment 
Range on Protein: 906-1028
Range on HMM: 27-162/274.0
DNHPKNRYGNNLPLQRNRVIL-----DSPDHDYINASQMKGIH---CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND-KSQNDKSCAQYWPDANSV-
 .. |||| . || .. ||.|     ...| .||||  .|| .    ... || |||.||.||| |. ... . |||| . | .| . ||.|.|||... 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---QFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNR
   ..|  .. . .. .  | ..|.| .   .....
iserygdveikvekiverndysvrklvlkylerers
subfamily_eak_pd Subfamily eak 610-855 2.5e-22 73.7 In-house 46-311 (332) alignment 
Range on Protein: 610-855
Range on HMM: 46-311/332.0
VAQEEINFKKNrYKNILPYDSVRVKLEVINDNPHsDYFNASYIPSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKP
...   . ..|   .|.|||   |.|     |.   | ||| .   .  . || .  ...  .  ||.|| ...  .| .. .  | .  |  ||.|.| 
etarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

GDSVKFGYIRVELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKHTS--ALLKFIKEVKAD-------------HGQYTH-----PLIIHC
 . .|||.. ||  .         | . . ||..   |  ...  | .  .||     || | .||| .                .| |       || .
reelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqs

SAGVGRTGVVISIDSVVA--HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
. |  |.|| . || ..    .| . .  | ...  ...|| . | .. |..||| .||. || ||  
arGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
subfamily_PTPN13_pd Subfamily PTPN13 881-1024 2.6e-22 74.4 In-house 14-161 (273) alignment 
Range on Protein: 881-1024
Range on HMM: 14-161/273.0
TKEFQTLKSLCpdpPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHdYINASQMKGI----HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
..||..|. |    |  ....|....|. |||| | || .. ||.|..    ||||| .|      . ... .| |||.||.||| || . | . |.|. 
aeefkelrelk...pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

-DKSQNDKSCAQYWPDANSVQFGS---YSVSTLSTSSDGDMTIRQLQVTRNS
 .| ..   | .|||. .. .      . |. | .    ....|.|.|. . 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse
subfamily_CG7180_pd Subfamily CG7180 877-1023 4e-22 73.2 In-house 12-164 (296) alignment 
Range on Protein: 877-1023
Range on HMM: 12-164/296.0
RSKMTKEFQTLKSLCPDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPS
| |.  |.. .  | |     . . |   .|  |||. . .|   |||.|..     . |||||. . .      .. |..|   || .||..| ... |
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIVMLNDKSQNDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
..|.| .. .  | . .|||     |.|   | .... .  ...||....|..
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 880-1030 1.2e-21 71.7 In-house 12-170 (287) alignment 
Range on Protein: 880-1030
Range on HMM: 12-170/287.0
MTKEFQTLKSLCpDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILD-SPDH--DYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVM
. ||...||    .  .   ..     .  ||||.. ||.  .||.|   ...  |||||  . . .   .|...| |...|| ||| .||... .....
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

L-NDKSQNDKSCAQYWPDAN-SVQFGSYSVSTLST-SSDGDMTIRQLQVTRNSKRN-RVI
.  .  .  . | .|||. .  .. | |||  |.    . . ..| |..     |. ||.
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 616-712 1.5e-21 71.5 In-house 47-157 (350) alignment 
Range on Protein: 616-712
Range on HMM: 47-157/350.0
NFKKNRYKNILPYDSVRVKLE-------VIN-DNPHSDYFNASYIP------SFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKC
 | ||||||||||.  ||||.        ..     .|| ||.|.       . . |  ||| |.| .  .|||.... . .|. | ..|.. | .  ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

GKYWPNKPGDS
 .||..   | 
yrYWqegsydd
0048179 (Phosphotyrosine protein) phosphatases II 742-842 2.4e-21 71.4 In-house 44-138 (144) alignment 
Range on Protein: 742-842
Range on HMM: 44-138/144.0
DDCRTVTQFHFTEWPDKGVPKHTSALLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVISIDSVVahakTTRmVDVFNFVTNIRQKRPYMVQTQEQYAFI
.  |...|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||... .. ..    . . ..... .  .|..||..|....|. |.
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

Y
.
l
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 880-1024 3.3e-21 70.3 In-house 17-168 (301) alignment 
Range on Protein: 880-1024
Range on HMM: 17-168/301.0
MTKEFQTLKSLCPDppasQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP------DHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPST
. .....||.  ..    ..  | . .|.. ||. |. ... ||.||          ..||||| ..|.     |. .| |.  |. ||| .....||..
feeqykelkegedk....sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLNDKSQN-DKSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLQVTRNS
|||. .. ..  ..| ||||...    .||  .|   ..    |..||||.|. . 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 906-1028 5.2e-21 69.9 In-house 2-131 (237) alignment 
Range on Protein: 906-1028
Range on HMM: 2-131/237.0
DNHPKNRYGNNLPLQRNRVILDSP--DHDYINASQMKGIHC---TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK-SQNDKSCAQYWPDANS-VQFG
.|. ||||||    . .||.|  .  . |||||. .||.     .....| || ..  ||| || ..| | ||||     .|.. | .|||...    .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVSTLSTSSDGDMTIRQLQVTRNSKRNR
 ..||        | |.| | .... . . 
vltvslkkkeefsdytvrslllskrltlke
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 652-883 2e-20 68.0 In-house 26-248 (255) alignment 
Range on Protein: 652-883
Range on HMM: 26-248/255.0
IPSFDNDKAYIASQgpnkaSMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVELVSleACTGGIKRTMTMLK----GDDCRTV
 |. |...  . |      ..| |.... | . ....|.. ..| .. || .|.| .  .  |.  . |      . .  . ||....         .||
kPekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtv

TQFHFTEWPDKGVPKHTSALLKFIKEVKADhgqytHPLIIHCSAGVGRTGVVISIDSVVA------HAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFI
. .... |..|  |. .  .|. .| |.       .....|||.|.||.   . ...|        .   |  .|  ......|.||.  ..|  | || 
khysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs

YGAVLEDLlwrntlIPVIHFTDHLQDLHSSgDGHGRSKMTKE
   ||. .       |  .. ...|... |   | |  | |.
ilmvldlv......fpkgeleakyqeirks.ylharqmmhkd
subfamily_PTPN14_pd Subfamily PTPN14 896-1028 2.6e-20 67.6 In-house 38-183 (300) alignment 
Range on Protein: 896-1028
Range on HMM: 38-183/300.0
ASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSP---DHDYINASQMK----GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQ
 ... ...  .| .|||. . || . ||| | .    ...|||||..|    | . .....| ||..|| ||| || ... . |||| .. .. |  . .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPDA----NSVQFGSYSVSTLSTSSDGDMTIRQLQVTR-NSKRNR
|.|.     ..|.|| . |.|  ... . .. ..|..    ||..|
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 880-1022 3.9e-20 66.7 In-house 29-176 (290) alignment 
Range on Protein: 880-1022
Range on HMM: 29-176/290.0
MTKEFqtLKSLCPDPP-ASQTRSGRTRDN-HPKNRYGNNLPLQRNRVIL-DSPDHDYINASQMKGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
..||.  |. | |  |     |.   ..    |||| .    .. |||| |  | ||. |  .||.. .|. || .|  || |.| |||..| ..|||| 
lakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlc

DKSQNDKS-CAQYWPDAN--SVQFGSYSVS-TLSTSSDGDMTIRQLQVTR
.  .. |. |.||.|. .   . ||...|  ..... | ..  . | |  
eliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrd
subfamily_ptpA1_pd Subfamily ptpA1 879-1000 1.4e-19 65.1 In-house 22-147 (418) alignment 
Range on Protein: 879-1000
Range on HMM: 22-147/418.0
KMTKEFQTLKSLCpdpPASQTRSGRTRDNHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC-TFMTTQMPLPTTVSDFWSMVLNNKPSTIV
|. .||. |.        |.|  |  . |  |||| | ||... || |    |    |||||  . | .   |. || ||| |..||| || .|.   ||
kikeefrlleesv...gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriiv

MLNDKSQNDK-SCAQYWPDAN-SVQFGSY
||. .|.| .  | .|||.     ||  |
mlsresencrikcdrywpeqiggeqfsiy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1026-1088 4.9e-19 63.6 In-house 65-131 (297) alignment 
Range on Protein: 1026-1088
Range on HMM: 65-131/297.0
RNRVIL----DSPDHDYINASNMKGVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK
..||.|    |.|| ||.||| .||..  ..||||| ..|| ||| |||....||||||||....||
ssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk
0050432 (Phosphotyrosine protein) phosphatases II 1026-1087 8.3e-19 63.5 In-house 82-146 (308) alignment 
Range on Protein: 1026-1087
Range on HMM: 82-146/308.0
RNRVILdSPDHDYINASNMKGV----HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.| ....|||||| ..|      ..|  || |||.|| ||| || ... ..||||..  .|.
hsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklveng
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 907-1029 1e-18 62.3 In-house 20-154 (270) alignment 
Range on Protein: 907-1029
Range on HMM: 20-154/270.0
NHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG---IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND-KSQNDKSCAQYWPDANSV---
..  ||| . ||  . ||.|..    .   ||||  ..|    ........ |||||...|| |....| ..|||. . . .. | |..|||  .     
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-QFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNRV
 ..|  .| .||.. .    ...|.........|.
ledgkikvlalseekeegyiltrlrleekgeerrl
subfamily_PTPRN_pd Subfamily PTPRN 877-1006 1.1e-18 62.0 In-house 28-163 (297) alignment 
Range on Protein: 877-1006
Range on HMM: 28-163/297.0
RSKMTKEFQTLKSLCPDPPASQTrsGRTRDNHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSMVLNNKP
.... ||...|..   .| ....  ... .|  |||. . || . .|| |..     ..||||||..      . ....|| ||..||.||| || ..  
kdrlekewealcayeaepstkev..akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

STIVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLS
  ||.|   ...  | |..||||  |  .. | |  .|
vvivnltrleeegvkqckrywpdeGsevyhiyevhlvs
0047943 (Phosphotyrosine protein) phosphatases II 1026-1087 4.1e-18 61.3 In-house 52-115 (273) alignment 
Range on Protein: 1026-1087
Range on HMM: 52-115/273.0
RNRVILDSPDHDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.|.....|||||| ..|  .  .|. ||.||| || ||| || ... ..||||..  ...
hsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelg
0036941 (Phosphotyrosine protein) phosphatases II 1026-1086 5.2e-18 60.8 In-house 53-115 (297) alignment 
Range on Protein: 1026-1086
Range on HMM: 53-115/297.0
RNRVILDSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..||.||....|||||| ..| .   .|. || |||.|| ||| ||.... ..||||..  ..
htRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1026-1088 5.3e-18 59.6 In-house 59-127 (392) alignment 
Range on Protein: 1026-1088
Range on HMM: 59-127/392.0
RNRVIL----DSPDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK
..||.|    |.||.||.||| ......  .....|.| .....|||.||......||.|...  . ||
sarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 615-850 6.4e-18 59.4 In-house 46-280 (303) alignment 
Range on Protein: 615-850
Range on HMM: 46-280/303.0
INFKKNRYKNILPYDSVRVKLEvindnpHSDYFNASYIpSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKpGDSVK
 |..|||. ...  |  .|||        | |  |||.  .| .|  | .| |   .  |||.|. ...|  . ..    | ||.     .|..  | .|
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflk

FG--YIRV-ELVSLEACTGGIKRTMTMLKGDDCRTVTQFHFTEWPDKGVPKH-TSALLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVVISIDSV--V
|   .||| |.  .|   |   . ... .||    .   |. .|| . .| . .. ..| | ....   .|.  .| .    .|.||.|    ...    
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

AHAkTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
 |.     .|. . . |.|. | . ||   |....|  . | .|
lhs.eqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
0046845 (Phosphotyrosine protein) phosphatases II 1026-1087 9.4e-18 60.0 In-house 42-115 (284) alignment 
Range on Protein: 1026-1087
Range on HMM: 42-115/284.0
RNRVILDS-----PDHDYINASNMKGV-------HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.|.|     .|.|||||| ..|        ...|. ||.|||.|| ||| ||.... ..||||..  .|.
hsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 771-849 1.1e-17 58.8 In-house 218-295 (297) alignment 
Range on Protein: 771-849
Range on HMM: 218-295/297.0
IKEVKADHGQyTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
.. ..|.. .   .|..||||||||.|||.  | ..|  .  |. ||  ... .|..|. .||| ||. ..| |||. |
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
DSPc_SM00195 1026-1087 2.5e-17 58.4 In-house 40-107 (263) alignment 
Range on Protein: 1026-1087
Range on HMM: 40-107/263.0
RNRVILDSPD----HDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.|....    .|||||. .||     ..  ||.|||.||.||| ||...| ..||||.. ..|.
htrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng
PTPc_SM00194 1026-1087 2.5e-17 58.4 In-house 40-107 (263) alignment 
Range on Protein: 1026-1087
Range on HMM: 40-107/263.0
RNRVILDSPD----HDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.|....    .|||||. .||     ..  ||.|||.||.||| ||...| ..||||.. ..|.
htrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng
0051299 (Phosphotyrosine protein) phosphatases II 1026-1087 3e-17 58.5 In-house 63-130 (288) alignment 
Range on Protein: 1026-1087
Range on HMM: 63-130/288.0
RNRVILDS----PDHDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.| .    ...|||||| ..|    ..|. || |||.||.||| || ... ..||||..   ..
hsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelg
subfamily_hpo-7_pd Subfamily hpo-7 670-847 6.4e-17 56.3 In-house 45-225 (263) alignment 
Range on Protein: 670-847
Range on HMM: 45-225/263.0
ASMDDFWRMVWQENVTTIAMVTKLKEGDKIKCGKYWPNKPGDSVKFGYIRVelVSLEACTGGIKRTMTMLK--G--DDCRTVTQFHFTEWPDKGVPKHTS
  .| |.... | . ....|..  .| .. || .|.| .  .  |.  . |  .. ..    ...|  .|.  |     .||... .. |..|  |. . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

ALLKFIKEVKADhgqytHPLIIHCSAGVGRTGVVISIDSVVA----H--AKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
  |. .| ..       ..|..|||.|.||.     ...|            |  .|  ......|..|.  ..|  | ||    ||.
eilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_CG42327_pd Subfamily CG42327 778-844 1.5e-16 54.9 In-house 243-310 (319) alignment 
Range on Protein: 778-844
Range on HMM: 243-310/319.0
HGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
. .   ||..||| ||||||.||. |  . . ... | ||. . |  .|. |   |.|.|||.|||  
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_PTPN23_pd Subfamily PTPN23 1026-1086 1.7e-16 54.9 In-house 57-120 (288) alignment 
Range on Protein: 1026-1086
Range on HMM: 57-120/288.0
RNRVILDSPDHDYINASNMKGVHC---TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
.||| |..   |||||| .|..     .|..|| ||..|..|||.|| ..| |.|||| .|.. 
hnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeel
0039614 (Phosphotyrosine protein) phosphatases II 1026-1087 1.8e-16 55.9 In-house 70-139 (297) alignment 
Range on Protein: 1026-1087
Range on HMM: 70-139/297.0
RNRVILDS-----PDHDYINASNMKGVHC---TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.| .     .|.|||||| ..| ..   .|  || ||| || ||| || ... ..||||..   ..
hsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 878-992 3.9e-16 53.9 In-house 6-118 (267) alignment 
Range on Protein: 878-992
Range on HMM: 6-118/267.0
SKMTKEFQTLKSLCPDppASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVML
 .. |||. .| . ..   |.     . .|. .||. .||| . .||||   ...||||| ..| .   .|. || ||  |..||. .. ..| ..||.|
ceiekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDKSqNDKsCAQYWPDA
      |.   ..||  
tkvf.tdn.irlfwPPk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 908-1030 4.9e-16 53.4 In-house 48-192 (350) alignment 
Range on Protein: 908-1030
Range on HMM: 48-192/350.0
HPKNRYGNNLPLQRNRVILD----S--------PDHDYINASQMK------GIHCTF--MTTQMPLPTTVSDFWSMVLNNKPSTIVMLND-KSQNDKSCA
  |||| | ||  ..||.|     |           |||||. .|       |   |  . || ||| || ||. ..|.||   |..|..   .| . | 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPDANSVQFGSYSVS-TLSTSSDGDMTIRQLQVTRNSKRNRVI
.||.. .  ..     |   .. .  |....  .| ...  |  |
rYWqegsydditvklaskwenimgindsslysadvkkeasdndni
Y_phosphatase Protein-tyrosine phosphatase 1026-1086 5.1e-16 54.2 Pfam-A 15-79 (235) alignment 
Range on Protein: 1026-1086
Range on HMM: 15-79/235.0
RNRVIL-DSPD-HDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||...| ..||||..  ..
ktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek
Y_phosphatase Protein-tyrosine phosphatase 1026-1086 5.1e-16 54.2 In-house 15-79 (235) alignment 
Range on Protein: 1026-1086
Range on HMM: 15-79/235.0
RNRVIL-DSPD-HDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||...| ..||||..  ..
ktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 786-849 6.9e-16 52.4 In-house 2-65 (69) alignment 
Range on Protein: 786-849
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
0040438 (Phosphotyrosine protein) phosphatases II 1026-1087 7.6e-16 53.7 In-house 57-124 (317) alignment 
Range on Protein: 1026-1087
Range on HMM: 57-124/317.0
RNRVILDS----PDHDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.| .    .|.|||||| ..|     .|  || ||| || ||| || ... ..||||..  ...
hsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelg
0045098 (Phosphotyrosine protein) phosphatases II 1026-1086 1.2e-15 53.1 In-house 47-101 (278) alignment 
Range on Protein: 1026-1086
Range on HMM: 47-101/278.0
RNRVIldspdhDYINASNMKGVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..||.      |||||| ..| . .|  || |||.||.||| |. ... ..||||..  ..
hsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 877-1026 1.7e-15 51.4 In-house 19-172 (439) alignment 
Range on Protein: 877-1026
Range on HMM: 19-172/439.0
RSKMTKEFQTLKSLCPDPPASQTRSGRTRDnHPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPS
.  ....|....|  ||  .  .   .  | ..|||| .  ...  ||.|      |   ||||  .|| .    ...||.|   |. ||| .|...| .
qeifkeifekinstspdyaciaslaaqeyd.qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

TIVMLNDKSQNDKscaqYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRNS---KR
||||| .  .  |    |||  . | .|  .| .       . .|| ..|  .    ..
tivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttek
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 786-849 1.8e-15 51.1 In-house 1-64 (69) alignment 
Range on Protein: 786-849
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
0045450 (Phosphotyrosine protein) phosphatases II 1026-1087 1.8e-15 52.9 In-house 69-145 (307) alignment 
Range on Protein: 1026-1087
Range on HMM: 69-145/307.0
RNRVILDS-----PDHDYINASNMKG----------VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.| |     .|.|||||| ..           .  .|. || ||| || ||| |. ... ..||||..   ..
htRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 907-1003 4.4e-15 50.4 In-house 35-137 (285) alignment 
Range on Protein: 907-1003
Range on HMM: 35-137/285.0
NHPKNRYGNNLPLQRNRVILDSPDHDYINASQMK--G-IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN-DKSCAQYWPDA--NSVQFGSY
|   ||| .   ..  ||.|   |.||| || |.  |  . |..||| ||| |.|||| |. ..| . ..||    .   . || |.|.   . |.|| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVS
 ..
eit
subfamily_egg_pd Subfamily egg 927-1044 4.5e-15 50.1 In-house 68-187 (307) alignment 
Range on Protein: 927-1044
Range on HMM: 68-187/307.0
DspdhDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNdKSCAQYWPDAN--SVQF--GSYSVSTLSTSSDGD--MTIRQL
|    |.| | ..||  .  .|. .| ||  || ||| || ...   ||||. . .. . |  ||| |.  |...  ||. . .|   |  |  ... .|
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

QVTRNSkRNRVILDSPDHDYINASNM
..     ..   |.    |. |.|..
klvGgd.deerflehwqgdvnnssdv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 905-1024 4.7e-15 50.2 In-house 31-161 (297) alignment 
Range on Protein: 905-1024
Range on HMM: 31-161/297.0
RDNHPKNRYGNNLPLQRNRVILD--SPDHDYINASQMK----GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND-KSCAQYWPDAN--SV
     |||| . |  . .|| |    ...|||||  .          .. .| || .|| ||| .| ..   .|||.    ..  . || |||...    
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

QFGSYSVSTLSTSSDG--DMTIRQLQVTRNS
. |.. |  ||. ||    . . .||.   |
kagdvvveflsstsdefdrviltelqliyrs
0043336 (Phosphotyrosine protein) phosphatases II 1026-1087 6e-15 50.9 In-house 59-126 (278) alignment 
Range on Protein: 1026-1087
Range on HMM: 59-126/278.0
RNRVILDSPD----HDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.|.. .    .|||||| ..|     .|  || ||| || ||| || ... .|||||..   ..
hsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 945-1016 1.4e-14 48.3 In-house 237-307 (440) alignment 
Range on Protein: 945-1016
Range on HMM: 237-307/440.0
TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDksQNDKSCAQYWP-DANSVQFGSYSVSTLSTSSDGDMTIR
.|..||||| .|| ||| .| . . |||.|||.   |||.|. ||| .. || || ..|    .     . .|
afiatqmpldstvldfwrlvhdyristiimlnq..lndktcsiywpvntrsvtfgpftvghkgsenmnrvkvr
subfamily_CG42327_pd Subfamily CG42327 907-1002 1.6e-14 48.3 In-house 28-135 (319) alignment 
Range on Protein: 907-1002
Range on HMM: 28-135/319.0
NHPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND-KSCAQYWPDANSV---
 ..|.|. | .||   ||.|..    .   |..|| ..|    .. ....|..|  . |||| .| ...  .|| | | |..  | ||.|.|  ..    
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

-QFGSYSV
  .| . |
slyGdilv
0041856 (Phosphotyrosine protein) phosphatases II 907-993 1.9e-14 49.1 In-house 1-75 (182) alignment 
Range on Protein: 907-993
Range on HMM: 1-75/182.0
NHPKNRYGNNLPLQRNRvildspDHDYINASQMKGIHCT--FMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNdksqndksCAQYWPDAN
|..|||| . ||  ..|      | |||||. . | . .  |  || ||. || ||. |. ... .|||.|.        . .|||.  
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell
subfamily_PTPRB_pd Subfamily PTPRB 1032-1082 6.1e-14 46.7 In-house 75-127 (293) alignment 
Range on Protein: 1032-1082
Range on HMM: 75-127/293.0
DSPDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
|... |||||. ..| ..   |..|| |||.|| ||| ||...| |.|||| .
desgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 903-1019 8.1e-14 46.4 In-house 4-127 (239) alignment 
Range on Protein: 903-1019
Range on HMM: 4-127/239.0
RTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWPDANS
. | |. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| |. ...   ||||    .   | | |||||. |
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

vQFGSYSVSTLSTSSDGDMTIRQLQ
 ..    |.   |    |  || . 
.kycnlrvtlrktevfadyiirtfv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1027-1087 8.5e-14 46.5 In-house 71-137 (298) alignment 
Range on Protein: 1027-1087
Range on HMM: 71-137/298.0
NRVILDS----PDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
 ||.| .     . |||||| ... .   .|..|| ||..||.||| || ... .|||||..  . |
sRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeld
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 903-1020 8.9e-14 46.2 In-house 3-127 (239) alignment 
Range on Protein: 903-1020
Range on HMM: 3-127/239.0
RTRDNHPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWPDANS
. | |. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| |. ...   ||||    .   | | |||||. |
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

vQFGSYSVSTLSTSSDGDMTIRQLQV
 ..    |.   |    |  || . .
.kycnlrvtlrktevfadyiirtfvm
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 746-846 1.1e-13 45.7 In-house 216-341 (350) alignment 
Range on Protein: 746-846
Range on HMM: 216-341/350.0
TVTQFHFTEWPDKGVPKHTSALLKFIK-------EVKA-DH--GQYTHPLIIHCSAGVGRTGVVISIDSVVA-------------HAK-TTRMVD-VFNF
 | |...  |.| ..  .   .|. ..       .  |  |   . . |...||||||||||.....||..              . . .... | ..  
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VTNIRQKRPYMVQTQEQYAFIYGAVL
| ..|..|  |||. .|. ||| |.|
vnelrkqrismvqnldqfifiYeall
fn3 Fibronectin type III domain 418-504 1.5e-13 43.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 418-504
Range on HMM: 2-85/85.0
SPTGLQVSAINHKELEVTWEHLPsksaECRSGVTNYMIYYAPTGSTS-SNSILVRNDTSSYTLGGLDTYLNYTIQLTASNKDEESDRS
.|..|.||.... .|...|.. .    . .. .|.| . |...|... .... | ..|.|.|| ||  . .|.....| |.. |. .|
aPenlsvsevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 616-708 2.4e-13 44.1 In-house 48-156 (349) alignment 
Range on Protein: 616-708
Range on HMM: 48-156/349.0
NFKKNRYKNILPYDSVRVKLEVINDNP--------------HSDYFNASYI--PSFDNDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKEGDKI
 | |||||.||||.  ||||.    ..                || || |.  . .. .| ||| | |  ...|||....  ..|  .  ... || .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCGKYWPNK
|| .|| . 
kcdiywqel
0049772 (Phosphotyrosine protein) phosphatases II 903-982 2.7e-13 45.8 In-house 42-155 (314) alignment 
Range on Protein: 903-982
Range on HMM: 42-155/314.0
RTRDNHPKNRYGNNLPLQrNRVILDS---PDHDYINASQMKGIhCTFMTTQMPLPTTVSDF----------WSMVL--NNKPSTIVM-------------
.   |. |||| . ||   |||||..    ..|||||| ..|. ..|. || ||. || ||          |.|||   ... .|||             
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LNDKSQND
        |.. . | 
daAlgKtpllildgng
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 572-655 3.1e-13 43.8 In-house 3-86 (440) alignment 
Range on Protein: 572-655
Range on HMM: 3-86/440.0
RQPLPLAQFPTFVNKNRHTTLFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNASYIPSF
..|. .|.|  .|..|| .  | .|.  ||     |  .|    |  ||||.||| ||  || || ..  |.||| ||||| . 
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
0040439 (Phosphotyrosine protein) phosphatases II 1026-1086 3.2e-13 45.3 In-house 25-91 (249) alignment 
Range on Protein: 1026-1086
Range on HMM: 25-91/249.0
RNRVILDS----PDHDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..||.| .    ...|||||| ..|     .|  || ||| ||.||| |. ... ..||||..  ..
hsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 906-1021 4.3e-13 43.5 In-house 51-172 (310) alignment 
Range on Protein: 906-1021
Range on HMM: 51-172/310.0
DNHPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDANS-VQFG
..  |||| . . |.  || |    |  .||| |  .|   .  ||. .| ||  |. ||| |.....  .|..|   ... .  |  |||       .|
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

SYSVSTLSTSSDgDMTIRQLQVT
   |. || ||. .. | .| ||
cirvtnlsesse.efeicnlavt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1033-1083 5.5e-13 43.6 In-house 72-124 (288) alignment 
Range on Protein: 1033-1083
Range on HMM: 72-124/288.0
SPDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
 .. |||||| ..| .   ....|| ||. || ||| .| .|| ||||||.. 
eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltel
0037934 (Phosphotyrosine protein) phosphatases II 1026-1084 7.6e-13 44.0 In-house 24-83 (243) alignment 
Range on Protein: 1026-1084
Range on HMM: 24-83/243.0
RNRVILdsPDHDYINASNMKGVHcTFMTTQMPLPTTVSD----FWSMVLNNKPSTIVMLNDKS
..||.|  ...|||||. ....  ..  ||.||| || |    || |. ... ..||||..  
hsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelv
subfamily_PTPRD_pd Subfamily PTPRD 1028-1085 1e-12 42.5 In-house 64-127 (564) alignment 
Range on Protein: 1028-1085
Range on HMM: 64-127/564.0
RVIL----DSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ
||.|      .. |||||| ..| .   ... || ||..|..||| || ... ||||||.  . 
RVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleE
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1033-1086 1.1e-12 42.8 In-house 71-126 (305) alignment 
Range on Protein: 1033-1086
Range on HMM: 71-126/305.0
SPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
 .|.|||||| ..| .   .....| ||..||.||| .... |.|||||| .  ..
lddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 901-992 1.9e-12 41.5 In-house 42-137 (305) alignment 
Range on Protein: 901-992
Range on HMM: 42-137/305.0
SGRTRDNHPKNRYGNNLPLQRNRVILDSP-DHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVML-NDKSQNDKSCAQYWPDA
. .  ... |||| .   |..||| |..|  |.|| |  .        |. || ||  | .||| | |..|  .| || | . .  | |..|..  
afkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask
0042113 (Phosphotyrosine protein) phosphatases II 1026-1087 1.9e-12 42.6 In-house 23-90 (245) alignment 
Range on Protein: 1026-1087
Range on HMM: 23-90/245.0
RNRVILDSPD----HDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
..||.| ...    .|||||| ..|     .|  || ||| || ||| |. ... .|||||..   ..
htrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 844-1003 2.2e-12 41.1 In-house 34-192 (244) alignment 
Range on Protein: 844-1003
Range on HMM: 34-192/244.0
AVLEDLLWRNTLIPVIHFTDHlQDLHSSGDGHGRSKMTKEF-QTLKS-LCPDPpaSQTRSGRTRDNHPKNRYGNNLPLQRNRVILD--SPDHDYINASQM
|||     .|  | .. | .  . . ||   .|   .  .. |  .. . |||  |  .     .|  ||| |  ||.. ||| |   |    ||||| .
avlsanatknryinilpfdet.rvilssskkegsdyinanyiqgsqniirpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv

K--GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDkscaQYWPDANSVQFGSYSVS
   |  . .. || ||  |  ||| |.|. .   .|.|    ..|    .||||.. ...    ..
gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeedit
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 878-994 2.5e-12 41.0 In-house 24-147 (305) alignment 
Range on Protein: 878-994
Range on HMM: 24-147/305.0
SKMTKEFQTL-KSLCPDPPASQTRSGRTRD-NHPKNRYGNNLPLQRNRVILDSPD-HDYINASQMKGI---HCTFMTTQMPLPTTVSDFWSMVLNNKPST
 |. .||. | |   ||       . .. | .  |||| .    ... | || |   ||| |  .      .  |. .| ||  |. .|| ||..||   
dklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveq

IVMLNDKSQNDK-SCAQYWPDANS
||||    .  |  |||||| |. 
ivmlcktvelgklkcaqywpaaqg
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1028-1087 5.4e-12 40.4 In-house 25-90 (250) alignment 
Range on Protein: 1028-1087
Range on HMM: 25-90/250.0
RVILDSP----DHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
||.| .     . |||||| ..| .   .|..|| ||..|. ||| |||..| .|||||.. ....
rvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkese
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 592-666 6.8e-12 39.4 In-house 24-95 (95) alignment 
Range on Protein: 592-666
Range on HMM: 24-95/95.0
LFSEEFHDLPGPNIYPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDnphSDYFNASYIPSFDNDKAYIASQG
 | .||. ..     | ||   | |  |||. ||.|||. || |    |   ||| || ..  .   ..|||.||
efdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 876-994 7.7e-12 39.8 In-house 14-133 (307) alignment 
Range on Protein: 876-994
Range on HMM: 14-133/307.0
GRSKMTKEFQTLKSLCPDPPASQTrsgrTRDNHPKNRYGNNLPLQRNRVILDSP--DHDYINASQMkGIH---CTFMTTQMPLPTTVSDFWSMVLNNKPS
| .... ||. |    |.  . ..     . |  |||| .    ...|...  .    ||| |  . ||      |. .| || .|. .||.|....|  
gvqalvdefrvlakktpegvtvea....fsantdknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekve

TIVMLNDKSQNDK-SCAQYWPDANS
...|| .  .  |  | ||||  . 
svimlckvielakikceqywpleeg
subfamily_PTPRK_pd Subfamily PTPRK 1029-1083 1e-11 39.2 In-house 64-120 (314) alignment 
Range on Protein: 1029-1083
Range on HMM: 64-120/314.0
VILDSPDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
.| . |. |||||. . . .    |. || ||. || ||| .|.... ..||||.. 
tidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1029-1086 1.3e-11 39.1 In-house 65-128 (319) alignment 
Range on Protein: 1029-1086
Range on HMM: 65-128/319.0
VIL----DSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
|.|    .... |||||| . | .    |. || || .|..||| || ... |..|||.. ...
vvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklvek
subfamily_PTPN1_pd Subfamily PTPN1 1026-1082 1.4e-11 38.6 In-house 46-104 (290) alignment 
Range on Protein: 1026-1082
Range on HMM: 46-104/290.0
RNRVILDSPDHDYINAS--NMKGVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
  |..|.. | ||||||  ... ..  .. || ||| ||. || || ..|  ..|||| 
hsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 945-1024 1.5e-11 38.9 In-house 5-87 (198) alignment 
Range on Protein: 945-1024
Range on HMM: 5-87/198.0
TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLQVTRNS
 ...|| ||  |..||| || .     |||.||  .| .   . ||| ..|   ..|| ||.| . ..  |.||  | .| |.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 945-1024 1.6e-11 38.8 In-house 6-88 (199) alignment 
Range on Protein: 945-1024
Range on HMM: 6-88/199.0
TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLQVTRNS
 ...|| ||  |..||| || .     |||.||  .| .   . ||| ..|   ..|| ||.| . ..  |.||  | .| |.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1032-1088 2.6e-11 38.0 In-house 73-131 (315) alignment 
Range on Protein: 1032-1088
Range on HMM: 73-131/315.0
DSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK
  |. ||.||. ..|      ....| |....| ||| .| ... ..||||..  ...|
ndphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegek
0051429 (Phosphotyrosine protein) phosphatases II 931-1024 3e-11 39.0 In-house 4-114 (272) alignment 
Range on Protein: 931-1024
Range on HMM: 4-114/272.0
HDYINASQMKGIhCT------FMTTQMPLPTTVSDFWSMvLNNKPSTIVMLNDKSQND-KSCAQYWP------------DANSVQFGSYSVSTLSTSSDG
 .||||. ..|  .       .  ...||| |. ||| .  ... .|||.| . .  .   | .|||            .| .. .| ..| .||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DMTIRQLQVTRNS
|...| |..|. .
dyilrellltlll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1026-1082 3e-11 37.5 In-house 70-127 (290) alignment 
Range on Protein: 1026-1082
Range on HMM: 70-127/290.0
RNRVIL-DSPDHDYINASNMKGVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
. |||| |  | ||. |  .||.. .|. || .|  || |.| |||..| ..|||| .
ktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlce
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1032-1084 3.1e-11 37.9 In-house 70-124 (318) alignment 
Range on Protein: 1032-1084
Range on HMM: 70-124/318.0
DSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKS
.... |||||. . | .   ... .| ||| |..||| || . . ..|||| ...
geegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1026-1087 5.2e-11 37.1 In-house 61-124 (287) alignment 
Range on Protein: 1026-1087
Range on HMM: 61-124/287.0
RNRVILDSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
 .||.|   ..|||||. ..| .    |. .. |.  |. .|| .. ......|||| .. .||
nyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekend
subfamily_ptpA1_pd Subfamily ptpA1 1022-1086 5.3e-11 36.9 In-house 61-126 (418) alignment 
Range on Protein: 1022-1086
Range on HMM: 61-126/418.0
RNSKRNRVILDSPDHDYINASNMKGVHC-TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
.   . . | |    |||||  . | .   |. || ||| |..||| || .|.   ||||. .|.|
htrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresen
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1028-1082 6.1e-11 36.9 In-house 44-106 (274) alignment 
Range on Protein: 1028-1082
Range on HMM: 44-106/274.0
RVIL-----DSPDHDYINASNMKGVH---CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
||.|     ...| .||||  .|| .    ... || |||.||.||| |. ... . |||| .
rvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk
subfamily_PTPRG_pd Subfamily PTPRG 1035-1086 6.8e-11 36.1 In-house 75-128 (563) alignment 
Range on Protein: 1035-1086
Range on HMM: 75-128/563.0
DHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..|||||. ..| .    |..|| ||..|. ||| |. ... ..|||. .  ..
klDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlver
subfamily_Ptp69D_pd Subfamily Ptp69D 1033-1086 7.6e-11 36.7 In-house 73-128 (307) alignment 
Range on Protein: 1033-1086
Range on HMM: 73-128/307.0
SPDHDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
. | |||||| .||   . .|.. | |. .|. ||| |. . .  .|||| . .. 
kedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltek
subfamily_PTPN12_pd Subfamily PTPN12 1032-1086 8e-11 36.3 In-house 64-120 (290) alignment 
Range on Protein: 1032-1086
Range on HMM: 64-120/290.0
DSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
.... |||||. .|||.  .... .| |||.|..||| |. . . . .||.  .  .
eeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevel
subfamily_PTPN6_pd Subfamily PTPN6 1027-1083 9.2e-11 36.3 In-house 69-132 (306) alignment 
Range on Protein: 1027-1083
Range on HMM: 69-132/306.0
NRVIL---DSPDHDYINASNMK----GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
.||||   . |..|||||. .|    | ......||  |.|||||||.||....   |||.  .
trvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttke
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1020-1080 1e-10 36.0 In-house 43-106 (285) alignment 
Range on Protein: 1020-1080
Range on HMM: 43-106/285.0
VTRNSKRNRVILDSPDHDYINASNMKG---VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVML
  |  .  ||.|   |.||| || |.     . |..||| ||| |.|||| |. ..| . ..||
dvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlml
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 885-1012 1.1e-10 35.7 In-house 15-152 (281) alignment 
Range on Protein: 885-1012
Range on HMM: 15-152/281.0
QTLKSLCPDPPASQTRSGRTRDNHPKNRYGNNLPLQRNRVILDS--P---DHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
| .  |  |||.          |  |||| |   |.  || |    |     ||| |  ..   ..  .. || |   | .||| |. ... ..|||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

K-SQNDKSCAQYWPDAN--SVQFGSYSVSTLSTSSDGD
    | . ||.|.|      .||  .|||   .. .  
fletnrekcaeyfprnahcclqfdklsvsyedstvnks
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1030-1087 1.7e-10 35.5 In-house 66-129 (325) alignment 
Range on Protein: 1030-1087
Range on HMM: 66-129/325.0
IL----DSPDHDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
.|    |.|. |||||| ..      .|...|.||..|. |.| .||. . | .|.||   ...
vletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk
subfamily_PTPRA_pd Subfamily PTPRA 1030-1082 4.2e-10 34.0 In-house 76-134 (330) alignment 
Range on Protein: 1030-1082
Range on HMM: 76-134/330.0
ILD----SPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
||      .. |||||| ..| .   .|...| |.  || ||| |. . | .||||| .
ilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte
subfamily_eak_pd Subfamily eak 895-1029 4.5e-10 33.4 In-house 40-181 (332) alignment 
Range on Protein: 895-1029
Range on HMM: 40-181/332.0
PASQTRSGRTRDNHPKNRYGnNLPLQRNRVILDSPD---HDYINASQMK--GIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND-KSCAQY
..   . ..  ..  .| ..  .| .|. | | |       ||||| ..   .   .. | ..  . |  || |||..|  .||.| .. ... .   .|
rllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPDAN--SVQFGSYSVSTLSTSSDGDMTIRQLQVTRNSKRNRV
.||     ..|| . | . .    . .  |.|....  .  ||
fpdktreelkfGildverkefvkrniletrllelskGnethrv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1028-1087 5.5e-10 33.6 In-house 62-129 (290) alignment 
Range on Protein: 1028-1087
Range on HMM: 62-129/290.0
RVILD----SPD--HDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQND
|..|      .|  ..||||. .||   .  .. || |.. |. |||... ..| . |||| .  ...
ritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieeg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1033-1083 5.9e-10 33.7 In-house 66-118 (281) alignment 
Range on Protein: 1033-1083
Range on HMM: 66-118/281.0
SPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
. . |||||. ..|..    ...|| |.|... .|| ||...| |.|||.  .
nkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtre
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1031-1086 6.2e-10 33.2 In-house 65-122 (301) alignment 
Range on Protein: 1031-1086
Range on HMM: 65-122/301.0
LDSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
||.  ..||||| ..|.     |. .| |.  |. ||| .....||..|||. .. ..
ldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkeg
subfamily_PTPN3_pd Subfamily PTPN3 1027-1083 7.1e-10 33.3 In-house 56-118 (280) alignment 
Range on Protein: 1027-1083
Range on HMM: 56-118/280.0
NRVILDSPDHDYINAS--NMK----GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
 ||.|.. . |||||.  ||.    |.   ...|| ||..|..||| || ..| |.|||| . 
trvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 931-993 7.3e-10 32.7 In-house 90-157 (349) alignment 
Range on Protein: 931-993
Range on HMM: 90-157/349.0
HDYINASQMKG----IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN-DKSQNDKSCAQYWPDAN
.|||||  .|     ..  ...||.|||.|| ||. ..|.|.   .. || || .. . | .|| . .
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 940-1022 7.4e-10 33.0 In-house 86-173 (301) alignment 
Range on Protein: 940-1022
Range on HMM: 86-173/301.0
KGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWPDA--NSVQFGSYSVSTLSTSS--DGDMTIRQLQVTR
.|    |..|| ||. |  ||| |.   .  .||||  | . . . |..| |    .... | ... . .. .  . ... |.|.|. 
sGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleved
fn3 Fibronectin type III domain 322-398 9.1e-10 31.7 Pfam-A 8-82 (85) alignment 
Range on Protein: 322-398
Range on HMM: 8-82/85.0
IVSTTSTTVGLRWDAWSeeddIGDPPLVGYDVFVM-E-DGD-WVMDQRANQLTtSAIVSNLTPDTDYRFGVAAVREGTGG
. ..|||.. |.|.. .     |. |..||.| .  . .|. |.  .. .. | |.....|.|.|.|.| |.|| ....|
vsevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngageg
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1026-1082 1e-09 32.7 In-house 47-108 (283) alignment 
Range on Protein: 1026-1082
Range on HMM: 47-108/283.0
RNRVILDSPDHDYINASNMK-----GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
..|| |.|  .|||||. .           .. .| ||  || ||| || ..| ..||||  
qwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk
0046846 (Phosphotyrosine protein) phosphatases II 922-996 1.1e-09 33.9 In-house 3-76 (176) alignment 
Range on Protein: 922-996
Range on HMM: 3-76/176.0
NRVILDSPDHDYINASQMKGihCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKS-QNDKSCAQYWPDANSVQ
 |.. . .| |||||. . |  . . .|| ||| |. ||. |..... ...|.|..    .  .|..|||.  ...
lrllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1036-1082 1.4e-09 32.8 In-house 53-102 (284) alignment 
Range on Protein: 1036-1082
Range on HMM: 53-102/284.0
HDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN-D
 |||||| ..|      ...|| ||. |. ||| |. . . ||||.|  |
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1036-1082 1.8e-09 32.3 In-house 89-138 (319) alignment 
Range on Protein: 1036-1082
Range on HMM: 89-138/319.0
HDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN-D
 |||||| ..|      ....| ||. |. ||| |. . . ||||.|  |
sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkd
0049772 (Phosphotyrosine protein) phosphatases II 1012-1079 2e-09 33.1 In-house 35-126 (314) alignment 
Range on Protein: 1012-1079
Range on HMM: 35-126/314.0
DMTIRQLQVTRNSKRNRVI-------------LDSPDHDYINASNMKGVhCTFMTTQMPLPTTVSDF----------WSMVL--NNKPSTIVM
..|| . .  .| ..|| .             |.  ..|||||| ..|. ..|. || ||. || ||          |.|||   ... .|||
eltilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm
subfamily_PTPN9_pd Subfamily PTPN9 1032-1081 3.4e-09 31.1 In-house 66-117 (297) alignment 
Range on Protein: 1032-1081
Range on HMM: 66-117/297.0
DSPDHDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
. .  |||||. . |   . .|..|| ||. |||||| || ...  .|||  
edeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1024-1082 3.5e-09 31.1 In-house 45-105 (267) alignment 
Range on Protein: 1024-1082
Range on HMM: 45-105/267.0
SKRNRVILDSPDHDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
 . .||||   ...||||| ..| .   .|. || ||  |..||. .. ..| ..||.|  
yddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 608-692 7.7e-09 29.5 In-house 29-118 (347) alignment 
Range on Protein: 608-692
Range on HMM: 29-118/347.0
QTVAQEEINFKKNRYKNILPYDSVRVKLEV-----INDNPHSDYFNASYIpSFDN-DKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTK
 |... | . .||| |.    |. || |        . ..   | |||.|  ||| .| || .| |   .. |||.||   .|| .  . .
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_PTPDC1_pd Subfamily PTPDC1 749-840 8.4e-09 30.1 In-house 84-167 (182) alignment 
Range on Protein: 749-840
Range on HMM: 84-167/182.0
QFHFTEWPDKGVPKHTSaLLKFIKEVKADHGQYthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRmvdvfNFVTNIRQKRPYMVQTQEQYAF
 ..   |.| ||.  .. .|  .| |.    .    . .|| || |||||.|.   | |.  |.      . .. .|.|||  .||.||  .
yvynfgwkDygvasler.iLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvel
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 665-847 1.4e-08 27.8 In-house 124-307 (346) alignment 
Range on Protein: 665-847
Range on HMM: 124-307/346.0
QGPNKASMDDFWRMVWQENVTTIAMvtkLKEGDKIKC--GKYWPNKPGDSVKFGYIRVELVSLEACTGGIKRTMTMLK-GDDCRTVTQ-FHFTEWPDKGV
|  |.. ..||| |..||..  . .   .   ||.|      . .. |     | . ..    .      . |. .|  |.    . |  | . |     
qmenesfvedfwymiyqeqihlvyl...mvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqq

PKHTSALLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| .|  ..|.|.. ....   .  . .    | ||.   |     .         .... . ||.|.||  |..  ||| ||  |..
ppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1033-1082 1.4e-08 29.1 In-house 45-97 (270) alignment 
Range on Protein: 1033-1082
Range on HMM: 45-97/270.0
SPDHDYINASNMK---GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
 .   ||||  ..   | ........ |||||...|| |....| ..|||. .
dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 781-847 1.6e-08 28.3 In-house 264-342 (349) alignment 
Range on Protein: 781-847
Range on HMM: 264-342/349.0
YTHPLIIHCSAGVGRTGVVISIDSVVA----HAK-------TTRMVDVFNFVTNI-RQKRPYMVQTQEQYAFIYGAVLE
 . .|..||||| |||||.. .|....      .        . . |.  .. |. |..|  |||   |. .|| |.|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_egg_pd Subfamily egg 1036-1086 2.6e-08 27.9 In-house 68-120 (307) alignment 
Range on Protein: 1036-1086
Range on HMM: 68-120/307.0
HDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
 |.| |  .||  .  .|. .| ||  || ||| || ...   ||||. . ..
ddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes
subfamily_PTPN14_pd Subfamily PTPN14 1035-1086 3.6e-08 27.7 In-house 75-130 (300) alignment 
Range on Protein: 1035-1086
Range on HMM: 75-130/300.0
DHDYINASNMK----GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
...|||||..|    | . .....| ||..|| ||| || ... . |||| .. ..
stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1036-1086 4.4e-08 27.2 In-house 83-141 (350) alignment 
Range on Protein: 1036-1086
Range on HMM: 83-141/350.0
HDYINASNMKGV------HCTF--MTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
 |||||. .|           |  . || ||| || ||. ..|.||   |..|...  .
nDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel
0051082 (Phosphotyrosine protein) phosphatases II 930-1021 5.2e-08 28.1 In-house 2-66 (151) alignment 
Range on Protein: 930-1021
Range on HMM: 2-66/151.0
DHDYINASQMKGIhctFMTTQMPLPttvsDFWSMVLNNKPSTIVMLNDKSQNDkSCAQYWPDANsvqfgsysvstlstssdgdMTIRQLQVT
  ||||.|.. |    .  ...||.    ||. .. ... .|||.|...  ..  |..|.|...                   .........
lsdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................ievlhipil
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1028-1081 5.2e-08 27.4 In-house 19-77 (237) alignment 
Range on Protein: 1028-1081
Range on HMM: 19-77/237.0
RVILDSP--DHDYINASNMKGVHC---TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
||.|  .  . |||||. .||.     .....| || ..  ||| || ..| | |||| 
rvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmlt
subfamily_CG7180_pd Subfamily CG7180 1034-1084 5.4e-08 26.8 In-house 68-120 (296) alignment 
Range on Protein: 1034-1084
Range on HMM: 68-120/296.0
PDHDYINASNMKGV--HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKS
 . |||||. . .   .  .. |..|   || .||..| ... |..|.| .. 
eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1036-1086 6.3e-08 26.3 In-house 90-144 (349) alignment 
Range on Protein: 1036-1086
Range on HMM: 90-144/349.0
HDYINASNMK----GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
.|||||  .|     |.  ...||.|||.|| ||. ..|.|.   .. |||  ..
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 931-1023 7.2e-08 26.9 In-house 46-153 (290) alignment 
Range on Protein: 931-1023
Range on HMM: 46-153/290.0
HDYINASQMKGI-HCTFMTTQMPLPT-------TVSDFWSMVLNNKPSTIVMLNDKSQNDK-----SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTI
 ||| |....      .. || |.         |. .|| |. . |   .||| . .....     .||.| |..    ..|.  .|.  |   . |. .
ddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RQLQVTRN
|.| |. .
Relvvkfd
subfamily_PTPN13_pd Subfamily PTPN13 1026-1085 7.3e-08 27.0 In-house 51-113 (273) alignment 
Range on Protein: 1026-1085
Range on HMM: 51-113/273.0
RNRVILDSPDHdYINASNMKGV----HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQ
. ||.|..    ||||| .|      . ... .| |||.||.||| || . | . |.|.  . .
etrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 918-1021 8.5e-08 26.6 In-house 4-101 (130) alignment 
Range on Protein: 918-1021
Range on HMM: 4-101/130.0
PLQRNRVIldspDHDYINASQM--KGIHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDkscaQYWPDANSVQFGSYSVSTLSTSSDGDMTI
. . .|.     ...||||| .   |    .. || ||  |  ||| |.|.     .|.|    ..|    .||||.. ...    .   .|  |.   |
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefkni

RQLQVT
.  .. 
kasnle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 657-720 8.9e-08 25.9 In-house 234-293 (440) alignment 
Range on Protein: 657-720
Range on HMM: 234-293/440.0
NDKAYIASQGPNKASMDDFWRMVWQENVTTIAMVTKLKegDKiKCGKYWPNKpGDSVKFGYIRV
. .|.||.| |  ... ||||.| . ...|| |. .|.  ||  |  ||| .   || || . |
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywpvn.trsvtfgpftv
0043147 (Phosphotyrosine protein) phosphatases II 929-978 9.5e-08 27.4 In-house 3-54 (172) alignment 
Range on Protein: 929-978
Range on HMM: 3-54/172.0
PDHDYINASQMKGIHCT--FMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
...|||||| ... ...  |  || ||. |..||| |. ... ..||.|.. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 605-700 1.3e-07 25.4 In-house 23-117 (332) alignment 
Range on Protein: 605-700
Range on HMM: 23-117/332.0
IYPQTVAQEEINFKKNRYKNILPYDSVRVKLevINDNPHSDYFNASYIPSFDNDKAYIASQGPNKA-SMDDFWRMVWQENVTTIAMVTKLKEGDKIK
 ||.|  .   |.  ||   .  .|  ||.|    .. . |..|||..  . .  ||| .| | .  .   ||||| . . . | ..  . | .| |
typntydkflnnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 929-989 1.3e-07 25.4 In-house 68-129 (347) alignment 
Range on Protein: 929-989
Range on HMM: 68-129/347.0
PDHDYINASQMKG--IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDkSQNDKSCAQYW
. . |||||..|    .  .. || ||| || ||| ||   | . .| . .  ..|..  .. 
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife.pikdeaieefa
0038934 (Phosphotyrosine protein) phosphatases II 749-841 1.4e-07 26.9 In-house 81-169 (194) alignment 
Range on Protein: 749-841
Range on HMM: 81-169/194.0
QFHFTEWPDKGVPKHTSALLKFIKEVKADHGQY-THPLIIHCSAGVGRTGVVIsidsvVAHAKTTRMVDVFNFVTNIRQKRPYMVQTQEQYAFI
...   .||.|..  .. ||.|.. |.  . .   .   .|| ||.||||...     .|.   ..  ..   .  .|.||| ....|...  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdyleal
0041856 (Phosphotyrosine protein) phosphatases II 1032-1082 1.5e-07 26.7 In-house 15-67 (182) alignment 
Range on Protein: 1032-1082
Range on HMM: 15-67/182.0
DSPDHDYINASNMKGVHCT--FMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
 |.| |||||. . | . .  |  || ||. || ||. |. ... .|||.|..
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlte
0043147 (Phosphotyrosine protein) phosphatases II 1034-1082 1.6e-07 26.7 In-house 3-53 (172) alignment 
Range on Protein: 1034-1082
Range on HMM: 3-53/172.0
PDHDYINASNMKGVHCT--FMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
...||||||........  |  || ||. |..||| |. ... ..||.|..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnlte
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 905-983 2e-07 24.9 In-house 45-122 (303) alignment 
Range on Protein: 905-983
Range on HMM: 45-122/303.0
RDNHPKNRYGNNLPLQRNRVILDspDHDYINASQMKG-IHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK
 .|  |||. . . |.  .| |   |  || || ..   .   . ||.||. | .||| |....|   ...|   |. ||
vknmdknrfvdvicldhskvkls..dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1050-1083 2.2e-07 24.6 In-house 237-270 (440) alignment 
Range on Protein: 1050-1083
Range on HMM: 237-270/440.0
TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
.|..||||| .|| ||| .| . . |||.|||. 
afiatqmpldstvldfwrlvhdyristiimlnql
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1036-1081 2.4e-07 24.8 In-house 65-112 (287) alignment 
Range on Protein: 1036-1081
Range on HMM: 65-112/287.0
HDYINASNMKGVH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
 |||||  . . .   .|...| |...|| ||| .||... ...... 
sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1031-1082 2.5e-07 24.5 In-house 66-118 (347) alignment 
Range on Protein: 1031-1082
Range on HMM: 66-118/347.0
LDSPDhDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
 | ..  ||||| .|    .  .. || ||| || ||| ||   | . .| . .
addve.tyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1022-1082 3.1e-07 24.6 In-house 45-109 (297) alignment 
Range on Protein: 1022-1082
Range on HMM: 45-109/297.0
RNSKRNRVILDSPDHDYINASNMK----GVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
 ...| ..    ...|||||  .          .. .| || .|| ||| .| ..   .|||.  
tddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak
0036282 (Phosphotyrosine protein) phosphatases II 931-998 3.3e-07 25.6 In-house 2-61 (174) alignment 
Range on Protein: 931-998
Range on HMM: 2-61/174.0
HDYINASQMKGIHCT--FMTTQMPLPttvsdFWSMVLNNKPSTIVMLNDKSQND-KSCAQYWPDansvqfG
.|||||| ... ..|  .  .| ||.     || |. ... .|.|||..  ...   | .|||.       
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe......l
0046846 (Phosphotyrosine protein) phosphatases II 1027-1083 3.6e-07 25.6 In-house 3-57 (176) alignment 
Range on Protein: 1027-1083
Range on HMM: 3-57/176.0
NRVILDSPDHDYINASNMKGvhCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
 |.. . .| |||||. . |  . . .|| ||| |. ||. |..... ...|.|.. 
lrllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnltee
0049260 (Phosphotyrosine protein) phosphatases II 944-1019 3.8e-07 25.4 In-house 9-56 (152) alignment 
Range on Protein: 944-1019
Range on HMM: 9-56/152.0
CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWpdansvqfgsysvstlstssdgdmtirqlQ
  |. || |.| |..||| |. ... .|||||.. . ..|  |.||.                             |
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................q
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 607-764 4.5e-07 22.9 In-house 18-158 (169) alignment 
Range on Protein: 607-764
Range on HMM: 18-158/169.0
PQTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNAsyipsfdndkayiasqgpnkasmddfwRMVWQENVTTIAMVtklkeGDKIKCGKYWP
 . .|.  .|  |||    |    .||||. . ..  ||| ||                           ||.|. | . | ..     ||      .||
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwp

NKPGD----SVKFG-------YIRVELVSLEAC--TGGIKRTMTMLKGDDCRT--VTQFHFTEWPDKGVPKHT
.|       .| .|       |.| . |   .    | .. .| . . ||  |  .. .|.. ||..|||.  
ekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqsp
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1033-1082 4.8e-07 23.6 In-house 73-124 (439) alignment 
Range on Protein: 1033-1082
Range on HMM: 73-124/439.0
SPDHDYINASNMKGVHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
 |   ||||  .|| .    ...||.|   |. ||| .|...| .||||| .
vphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltn
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 907-998 6.4e-07 23.7 In-house 43-139 (288) alignment 
Range on Protein: 907-998
Range on HMM: 43-139/288.0
NHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC--TFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQNDK-SCAQYWPDA--NSVQFG
|  ..|| |       || |.   . ||.|  .   .    .. .| || .|.  .| |.|..    ||||..  .  |   |.|.|    .....|
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1021-1083 6.5e-07 23.2 In-house 63-128 (310) alignment 
Range on Protein: 1021-1083
Range on HMM: 63-128/310.0
TRNSKRNRVILD-SPDHDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDK
 ... | .. .| |  .||| |  .|   .  ||. .| ||  |. ||| |.....  .|..|   
cldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 956-1023 6.8e-07 23.6 In-house 40-108 (255) alignment 
Range on Protein: 956-1023
Range on HMM: 40-108/255.0
TVSDFWSMVLNNKPSTIVMLNDKSQ-NDKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
||  |. ..  .|....||| |  . . . | .|.|     .     |.  .| |  |. .| |..| .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitst
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 608-764 7.9e-07 22.0 In-house 18-157 (169) alignment 
Range on Protein: 608-764
Range on HMM: 18-157/169.0
QTVAQEEINFKKNRYKNILPYDSVRVKLEVINDNPHSDYFNAsyipsfdndkayiasqgpnkasmddfwRMVWQENVTTIAMVtklkeGDKIKCGKYWPN
. .|.  .|  |||    |    .||||. . ..  ||| ||                           ||.|. | . | ..     ||      .||.
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpe

KPGDSVK----FG-------YIRVELVSLEacTGGIK--RTMTMLKGDDCRTVTQ----FHFTEWPDKGVPKHT
|    ..    .|       |.| . |  .  | |..    .......  ..||.    .|.. ||..|||.  
kedyqlhpavilGewytdslyvrtdkvhpn..tsgveglfevslvihsydddvteqlsllhystwpqngvpqsp
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1043-1086 8.3e-07 23.0 In-house 84-127 (301) alignment 
Range on Protein: 1043-1086
Range on HMM: 84-127/301.0
NMKGVHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
. .|    |..|| ||. |  ||| |.   .  .||||  | ..
ptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvek
subfamily_CG42327_pd Subfamily CG42327 1013-1086 8.4e-07 22.9 In-house 33-109 (319) alignment 
Range on Protein: 1013-1086
Range on HMM: 33-109/319.0
MTIRQLQVTRNSKRNRVILDSPDHDYINASNMKGV---HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
  |. . .   .   . | | .   |..|| ..|    .. ....|..|  . |||| .| ...  .|| | | |..
rvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlsel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 905-992 1e-06 22.4 In-house 49-141 (302) alignment 
Range on Protein: 905-992
Range on HMM: 49-141/302.0
RDNHPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIHC--TFMTTQMPLPTTV---SDFWSMVLNNKPSTIVMLNDKSQNDKSCAQYWPDA
..|  ||.  .   |. |.|.|.    .|.|||...  ..  . . .|.|  ...    .|| || ..|  ..|.|  . . .|.  ...|  
kknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1026-1081 1.1e-06 22.7 In-house 62-120 (305) alignment 
Range on Protein: 1026-1081
Range on HMM: 62-120/305.0
RNRVILDSP-DHDYINASNMKG--VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
.||| |..|  |.|| |  .        |. || ||  | .||| | |..|  .| || 
nnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc
subfamily_PTPRN_pd Subfamily PTPRN 1035-1086 1.1e-06 22.7 In-house 83-137 (297) alignment 
Range on Protein: 1035-1086
Range on HMM: 83-137/297.0
DHDYINASNMKG---VHCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLNDKSQN
..|||||| .      . ....|| ||..||.||| || ..    ||.|   ...
ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleee
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 880-992 5e-06 20.4 In-house 21-131 (312) alignment 
Range on Protein: 880-992
Range on HMM: 21-131/312.0
MTKEFQTLKSLCPDPPAsqTRSGRTRDnhpKNRYGNNLPLQRNRVILDSPDHDYINASQMKGIH--CTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLND
.|||....  . .|     |   . .|    ||| |    .| |  |   .  || |  .|       |..|| ||  |.. || ..|.   ..|..|  
ltkeykavgnivsdsec..taflkfkd...lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

KSQ-NDKSCAQYWPDA
  .   . ||.|  | 
fvedgsekcakyisdi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1017-1081 5.7e-06 20.2 In-house 60-128 (305) alignment 
Range on Protein: 1017-1081
Range on HMM: 60-128/305.0
QLQVTRNSKRNRVILDSPD-HDYINASNMkGV----HCTFMTTQMPLPTTVSDFWSMVLNNKPSTIVMLN
. |      .. | || |   ||| |  . |.    .  |. .| ||  |. .|| ||..||   |||| 
ryqdvpcqdqsavkldkpspsdyihanyv.gcpmipekrficaqgpldqtidefwwmviqnkveqivmlc
0051429 (Phosphotyrosine protein) phosphatases II 1036-1084 5.8e-06 21.7 In-house 4-56 (272) alignment 
Range on Protein: 1036-1084
Range on HMM: 4-56/272.0
HDYINASNMKGVhCT------FMTTQMPLPTTVSDFWSMvLNNKPSTIVMLNDKS
 .||||. ..|  .       .  ...||| |. ||| .  ... .|||.| . .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrsee
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 606-655 5.9e-06 20.1 In-house 29-77 (244) alignment 
Range on Protein: 606-655
Range on HMM: 29-77/244.0
YPQTVAQEEINFKKNRYKNILPYDSVRVKLEVINdNPHSDYFNASYIPSF
. || |    |  |||| ||||.| .|| |   . .  ||| ||.|| . 
flqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
subfamily_hpo-7_pd Subfamily hpo-7 954-1023 7.8e-06 20.0 In-house 44-114 (263) alignment 
Range on Protein: 954-1023
Range on HMM: 44-114/263.0
PTTVSDFWSMVLNNKPSTIVMLNDKSQN-DKSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLQVTRN
  |.  |....  .|....||| |   .  . | .|.|     .     |.  .| .  |. .. |... .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellst
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 858-941 8.5e-06 19.9 In-house 7-83 (95) alignment 
Range on Protein: 858-941
Range on HMM: 7-83/95.0
VIHFTDHLQDLHSSGDghgrSKMTKEFQTLkslCPDPPASQTrSGRTRDNHPKNRYGNNLPLQRNRVILDS-PDHDYINASQMKG
|  |  |. ..||  |     .. .||...        |. |  | .  | ||||. | .| .  ||.| .  | |||||  . |
vsvfhshvlemhsnsd....qefdnefksi...smtsgapyt.vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdg
subfamily_DSP10_pd Subfamily DSP10 762-825 8.6e-06 19.7 In-house 76-133 (159) alignment 
Range on Protein: 762-825
Range on HMM: 76-133/159.0
KHTSALLKFIKEVKadhgQYTHPLIIHCSAGVGRTgVVISIDSVVAHAKtTRMVDVFNFVTNIR
..  . |.||.|..    .  . ...|| ||. |  . . |  ...| .   . | ..|| . |
qyfeealefieear....kkgsrvLvhCqaGisrs.atvviaYlmkhln.lslndaykfvkekr