Gene SpurPTP-sf1-14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP091_AA protein Get Run
SpurP091_AA_0-180 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 2-179 9.8e-48 158.4 In-house 116-299 (308) alignment 
Range on Protein: 2-179
Range on HMM: 116-299/308.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA---NPNIKQPFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDF
||..|| || |.........||||..|   .      || .    .. .  .|. ..|.. . ...| |||||..   ...|...||....|.. .  . 
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

YQTLLDFMNNVTSQQgGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
 . ||||.. | ... ...|..||| .||||||.|... ..|.||| |  ||||..|| ||.   .|.|..| |...||.| ...
peilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_PTPRD_pd Subfamily PTPRD 2-185 3.6e-47 156.2 In-house 99-287 (564) alignment 
Range on Protein: 2-185
Range on HMM: 99-287/564.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLEL--KHRKNTRIIQHFQFLSWKEVDSVDFYQT
||..|. || |.......||||||. |. ..    . || | ..   . .  .. ...| .. . ||..|  |.....| ...|.| || . .  .. ..
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesats

LLDFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQEN
|||....|.. .  .  |..||| .||||||.|.|....|.... |. ||..|.|||||..   |.|. | |  ....... .|. ...
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0051299 (Phosphotyrosine protein) phosphatases II 2-178 3.5e-46 153.3 In-house 100-285 (288) alignment 
Range on Protein: 2-178
Range on HMM: 100-285/288.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK------HRKNTRIIQHFQFLSWKEVDSVD
||..|| || |.........||||..|   .   .  || . .. .  ... . |.... ...| ||||..        ...|...||....| . .  |
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

FYQTLLDFMNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
  . ||||.. | .. . |..||.||| .||||||.|... ..|.||| |  |||...|| ||.  ..|.|..| |...|..| ..
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-180 3.2e-45 149.7 In-house 107-291 (298) alignment 
Range on Protein: 2-180
Range on HMM: 107-291/298.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQT
|| .||.|| |.. .. |.|||||..|   |    . || . . .    .....| . |    . |.|.....|  ..| .....| || . .    ...
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenats

LLDFMNNVT--SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
.||....|    || |..||.|.| .||||.| |....  |.... |  |||||.||.||..  ...|. |.|. .| .  . ..
vldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0046845 (Phosphotyrosine protein) phosphatases II 2-179 4.9e-45 149.5 In-house 85-274 (284) alignment 
Range on Protein: 2-179
Range on HMM: 85-274/284.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEAN-PNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFY
||..|| || |.........||||..|   .    . || . . . .  .|. ..|.. . ...| |||||..    ...|...||...|| . .  .  
PlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppsp

QTLLDFMNNVTSQQGG---DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVED---AVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
. ||.|.. | ...     ..|..||| .||||||.|... ..|.||| |.    |||...|| ||   ..|.|.|| |...|..| ...
edlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-186 5e-45 149.0 In-house 97-290 (305) alignment 
Range on Protein: 2-186
Range on HMM: 97-290/305.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPN--IKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDF
|| .||.|| |||.....|||||| .| ...      || |.  .    ..||... .. . . ..|| |..      |..| . ..|. .| .   ..|
PlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf

YQTLLDFMNNVTSQQGGD--SPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQENT
  .||.....|. .|  |   |.|||| .||||||||..|.. |..|. |. ||||...|.||.   .|.|.|. |  .. .|. |.   . . 
atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsi
Y_phosphatase Protein-tyrosine phosphatase 2-175 1.2e-44 147.9 Pfam-A 50-233 (235) alignment 
Range on Protein: 2-175
Range on HMM: 50-233/235.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWD--EANPNIKQPFSMNVL-DTV-ESEHWTERTLELKHRKNT---RIIQHFQFLSWKEVDSV
||..|. || |.........||||..| ..   . . ||.  | ...  . .....  ..  .....| |.||||..|.    |....... .|.. .  
PlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp

DFYQTLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
. .. |||....| ...   ..||.||| .||||||.|......|.||| |. |||.|||| ||.  ..|.|||| |. .|...
espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 2-175 1.2e-44 147.9 In-house 50-233 (235) alignment 
Range on Protein: 2-175
Range on HMM: 50-233/235.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWD--EANPNIKQPFSMNVL-DTV-ESEHWTERTLELKHRKNT---RIIQHFQFLSWKEVDSV
||..|. || |.........||||..| ..   . . ||.  | ...  . .....  ..  .....| |.||||..|.    |....... .|.. .  
PlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp

DFYQTLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
. .. |||....| ...   ..||.||| .||||||.|......|.||| |. |||.|||| ||.  ..|.|||| |. .|...
espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0047943 (Phosphotyrosine protein) phosphatases II 2-177 2.1e-44 147.4 In-house 85-270 (273) alignment 
Range on Protein: 2-177
Range on HMM: 85-270/273.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEAN---PNIKQPFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDF
||..|| ||.|.........||||..|   .      || . .   . .  .|. ..|.. . ...| |||||..   ...|...||....| . .  . 
PlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpps

YQTLLDFMNNVTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
.. ||.|.. | ...    ...||.||| .||||||.|... ..||||| |  |||...|| ||   . |.|..| |...|..| .
lesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 2-178 3.7e-44 146.6 In-house 86-276 (297) alignment 
Range on Protein: 2-178
Range on HMM: 86-276/297.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA--NPNIKQPFSMNVLDTVE--SEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVD
||..|| || |.........||||..|   .      || .   ..    .|....|.. .  ....| ||||...   ...|...||....| . .  .
PlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe

FYQTLLDFMNNVTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLE---VEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
 ...||||.. | ...    ...|||||| .||||.|.|... ..|.|||    |  ||....|| ||.  ....|.|| |. .|..| .|
spaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-185 1e-43 144.6 In-house 99-289 (297) alignment 
Range on Protein: 1-185
Range on HMM: 99-289/297.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS-SIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWK--EVDSVDFY
||  .|| || ....|...||||||||....| .   || .   .     |. .| . | |   .|.||... |  ..|... .||..|   .|.  |  
mPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

QTLLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMaMSQEN
..||.....|  . .   ..|.|||||.|||||||.. .. .. . . |..||.|..|| ||..  ...|  |.||. | ...  . .|.. 
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal.lsedt
0039614 (Phosphotyrosine protein) phosphatases II 2-178 1.1e-43 145.2 In-house 109-288 (297) alignment 
Range on Protein: 2-178
Range on HMM: 109-288/297.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA-SSIYWDEANPnIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLD
||..|| ||.|.........||||..|   .     || |       .|. ..|.. . ...| ||||... . .|...|||...| . .  .  ..||.
PlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellle

FMNNVTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
|.. | ...    .. |||||| .||||||.|..  ..|.||| |  |||...|| ||    ...|... |. .|..| .|
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0040438 (Phosphotyrosine protein) phosphatases II 2-179 5.2e-43 142.9 In-house 94-276 (317) alignment 
Range on Protein: 2-179
Range on HMM: 94-276/317.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQT
||..|| ||.|.........||||..|   .   .  || . ..    .|....|...| ...| ||||...   ...|...||....| . .  .  ..
PlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdl

LLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
||||.. | ... . ..|||||| .||||||.|... ..|.||| |  |||...|| ||.   ...|..| |. .|..|....
lldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
DSPc_SM00195 1-179 2.6e-42 140.3 In-house 76-262 (263) alignment 
Range on Protein: 1-179
Range on HMM: 76-262/263.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEA--NPNIKQPFSMNVLDTVESE-HWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVD
.||..|| || |.... ....||||.. ...     . || |   ...  . .| .. .. . . ... |||||.. .  .|| ....|. .|.. .  |
gPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

FYQTLLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
  . .|.... |....   ..|..||| .||||||.|......|..|| |. ||.|.|||.||.  ..|.|.|| |. .|... ...
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-179 2.6e-42 140.3 In-house 76-262 (263) alignment 
Range on Protein: 1-179
Range on HMM: 76-262/263.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEA--NPNIKQPFSMNVLDTVESE-HWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVD
.||..|| || |.... ....||||.. ...     . || |   ...  . .| .. .. . . ... |||||.. .  .|| ....|. .|.. .  |
gPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

FYQTLLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
  . .|.... |....   ..|..||| .||||||.|......|..|| |. ||.|.|||.||.  ..|.|.|| |. .|... ...
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-181 4.6e-42 139.0 In-house 98-281 (288) alignment 
Range on Protein: 2-181
Range on HMM: 98-281/288.0
PLSQTVTDFLRLIYDYRISTIVMLNDL--SKEDASSIYWDEA-NPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTL
|| .|| || .|.|....||||||..|    .     || .| .|.    . . .... | |....|.|.|...|. . |...|.|.| . .  .  . |
PladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapl

LDFMNNVTSQQGGD-SPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAM
|.....|  ..  |  |..||| .||||||.| .... .|..| || .||. .|. ||.  ....| |. |  .|..| .|.  
lellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_PTPRK_pd Subfamily PTPRK 2-175 9e-42 138.0 In-house 94-273 (314) alignment 
Range on Protein: 2-175
Range on HMM: 94-273/314.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNiKQPFSMNVLDTVESEHWTERTLELKH----RKNTRIIQHFQFLSWKEVDSVDFY
|| .||.|| ||.||.. ..||||..| ..     . || |      ... .....|   .    |.. ...     ...|....||||.| . |     
PlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsa

QTLLDFMNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
..||... .| .. . .. ...|||..| ||||.|..... || .| |. ||||..||.||     |..  | ||..| ..
tgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0043336 (Phosphotyrosine protein) phosphatases II 2-177 9.4e-42 138.8 In-house 96-275 (278) alignment 
Range on Protein: 2-177
Range on HMM: 96-275/278.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDeANPNIKQPFSMNVLDTVESEHWTERTLELK--HRKNTRIIQHFQFLSWKEVDSVDFYQT
||..|| || |........|||||..|   .   .  ||   ..    .|. ..|.. . ...| ||||..    ...|...|...|.| . .  .  ..
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

LLDFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
||||.. | ...   ..|||||| .||||||.|... ..|.||| |  ||....|| ||.  ....|... |. .|..| .
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-187 3.4e-41 136.4 In-house 99-292 (319) alignment 
Range on Protein: 2-187
Range on HMM: 99-292/319.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKN---TRIIQHFQFLSWKEVDSVDFYQ
||..|. || |.......|..|||..|. .     . ||.|.|..    . .....  | |..  | |.|.....   || ..|||...| . |  .  .
PlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

TLLDFMNNVTS-QQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ-ENTL
.|||.....   ...  . |. ||| .|||||| |.|... |.... | ..|||..|. ||     |.|  | ||..| .| . . . . |  .
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteiev
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-182 3.4e-41 136.1 In-house 60-245 (250) alignment 
Range on Protein: 2-182
Range on HMM: 60-245/250.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA-SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKNT--RIIQHFQFLSWKEVDSVDFYQTL
||..|. || |..... ..|||||..|. ..   . ||   ....     ...|.. |   .| |.| | ..|..  ||.....|..| .    . ... 
PlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatav

LDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMS
|.....| .  || |..||.|.| .||||.| |....  |..|. |  ||||...|.||.|  ....||| |  .|.|. . .  .
LellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0040439 (Phosphotyrosine protein) phosphatases II 2-178 1.1e-40 135.2 In-house 62-245 (249) alignment 
Range on Protein: 2-178
Range on HMM: 62-245/249.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK--HRKNTRIIQHFQFLSWKEVDSVDFYQT
||..|| ||.|......|..||||..|          ||.. ..     |. ..|.. .....| |||||.    ...| ..|.|...| . .  .. ..
PlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfed

LLDFMNNVTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
||||.. | . .     ..|||||| .||||||.|..  ..|.||| |  ||....|| ||.  ....|..| |. .|..| .|
lldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 2-178 1.2e-40 135.5 In-house 115-303 (307) alignment 
Range on Protein: 2-178
Range on HMM: 115-303/307.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA-NPNIKQPFSMNVLDTVESEHWTERTLELK---HRKNTRIIQHFQFLSWKEVDSVDFY
||..|| ||.|.........||||..|   .      || .   .    .| ...|.. . ...| ||||..     ...|...||....| . .  .. 
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

QTLLDFMNNVTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA---VDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
..||||.. | . ..   ...||||||  ||||||.|..  ..|.||| |     ||....|| ||    ...|..| |. .|..| .|
eelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-184 6.1e-40 132.2 In-house 97-285 (318) alignment 
Range on Protein: 2-184
Range on HMM: 97-285/318.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQT
||..|..|| |....   ..|||| ... .       || . ...  .   ... ..||..... |........  ..|... ... || . .. .   .
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgas

LLDFMNNVTSQQ--GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQE
|||.. .|.. |   | .|..|||  ||||||||..|.. |.... |  |||||.|| ||.    |.|  . |...| .|   .|  . 
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
0042113 (Phosphotyrosine protein) phosphatases II 2-177 7.5e-39 129.0 In-house 60-241 (245) alignment 
Range on Protein: 2-177
Range on HMM: 60-241/245.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK--HRKNTRIIQHFQFLSWKEVDSVDFYQT
||..|| ||.|......|.|||||...   .   .  || . ..     |....|..   ...| ||||..    . .| ..|...|.| . .  |  ..
PlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllel

LLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
||||.. | ...   .. ||||||  ||||||.|... ..|.||| |  |.....|| ||    ...|... |. .|..| .
lldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 2-184 3.9e-38 126.2 In-house 102-290 (293) alignment 
Range on Protein: 2-184
Range on HMM: 102-290/293.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA-NPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTL
|| .|| || |.... . |.|||| .|  .       || .  .| .    ..... . | |.|. |.|.....|..| .....|.|| . .  .  .||
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

LDFMNNVTSQQ---GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQE
|||...| ...     ..|..|||  ||||||.|  ... |...| || ||.| || .||.. ....|. ..|   .. . .|.  ..|
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-177 6.3e-38 125.3 In-house 99-281 (290) alignment 
Range on Protein: 2-177
Range on HMM: 99-281/290.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKN---TRIIQHFQFLSWKEVDSVDFYQ
|.|.|. || .||.. ... |||| .  .|.      || ... .  ..||...|.  . .. .||.||.|....   .......|. .|.. ..|  .|
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq

TLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
| |  .....    . |. ...||| ..|||..|||.... ... . |  .||||..| .|    ...|. . |.. ..|. .
tillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-179 1.3e-37 124.3 In-house 94-277 (315) alignment 
Range on Protein: 1-179
Range on HMM: 94-277/315.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIK--QPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQ
.||  .| || |........||||.......|      || . . .      .....|..      . | | ... ...| .  |||  | .  .     
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts

TLLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
.|| .. .| ...|  . ..||||. |||||||.. .. ...|.. ...||||..|| || .  ...|. |.| . | ..   .
sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
0045098 (Phosphotyrosine protein) phosphatases II 2-178 6.8e-37 122.8 In-house 72-271 (278) alignment 
Range on Protein: 2-178
Range on HMM: 72-271/278.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR----KNT--RIIQHFQFLSWKEVDSVD
|| .|| ||.|......|..||||..|   .      || | .. .  .|. ..|.. . ...| |||.. .     ..   | ..|...|.| . .. .
Plpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvps

FY--QTLLDFMNNVTSQQG--------------GDSPVLVHCLNGVGRTGVFCVVKMCLDQLevEDAVDVFQIVKALRHDNFQ-MIQSLEDYKLCYRILN
.   . .|.... . . .               .. ||||||  ||||||..... ..|..|  |. ||....|| ||    . ..|.|| |. .|. | 
lpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefll

HL
.|
el
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-178 9.3e-37 121.6 In-house 100-278 (315) alignment 
Range on Protein: 2-178
Range on HMM: 100-278/315.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDASS--IYWDEAnPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLL
|. ..| || ||.... |..||||..| ... .    || .    |  ....   .    ...| |||    ..| | .  ... || ...   .  .|.
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplm

DFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
... .|   .    ....||| .|||||| |. ..  |||.|.|.|.||..... .|.   .|.|..| |.. | .|   
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-175 1.3e-36 120.9 In-house 83-262 (283) alignment 
Range on Protein: 2-175
Range on HMM: 83-262/283.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSK--EDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR---KNTRIIQHFQFLSWKEVDSVDFYQ
|| .|| || ....| .|..||||  |    . . | || .       .| . . . . |. .. . | |..    |.| .. |.|.  | |..      
PldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiin

TLLDFmNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
.|. | | | |.|    ..|..||| .|.|||.||. .   ....  |  ||||..|| .| .   ..|.|. ||| . . 
slvkf.nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPRA_pd Subfamily PTPRA 2-178 3.1e-36 119.9 In-house 109-294 (330) alignment 
Range on Protein: 2-178
Range on HMM: 109-294/330.0
PLSQTVTDFLRLIYDYRISTIVMLNDLS--KEDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK------HRKNTRIIQHFQFLSWKEVDSVD
|...|| || |.|.... .||||| .|   ||.    || .          ..| |.......| | . ..      ..|..|... | | || .|    
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

FYQTLLDFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
  . .|.....| ...    .|. |||  |||||| |.|..  |.... |  ||||..|| ||    ||.|..| |...|..| . 
epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Ptp69D_pd Subfamily Ptp69D 2-182 3.6e-36 119.9 In-house 99-289 (307) alignment 
Range on Protein: 2-182
Range on HMM: 99-289/307.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEAnpNIKQPFSMNV--LDTVESEHWTERTLELKHRK-------NTRIIQHFQFLSWKEVD
|. .|. || |.| .  . .|||| .|.  .    . || .   ...|  ...|   .. . .....|.|.. . |       ..| .  .....||.. 
PveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDsk

SVDFYQTLLDFMNNV-TSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMS
  .  ..||.....|   ..   ||..||| .||||.|.|  ... |.||. || ||.|..|| ||..   ..|||| |. .|| |   . ..
vPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
0037934 (Phosphotyrosine protein) phosphatases II 1-178 4.3e-36 120.1 In-house 51-241 (243) alignment 
Range on Protein: 1-178
Range on HMM: 51-241/243.0
MPLSQTVTD----FLRLIYDYRISTIVMLNDLS--KEDASSIYWDeaNPNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDS
.||..|| |    |.|......|..||||..|   .      ||   ..    .|. ..|.. . ...| |||.|..    . || ..|...|.| . . 
gPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgv

VDFYQTLLDFMNNVTS---------QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLeveDaVDVFQIVKALRHDNFQ-MIQSLEDYKLCYRILNHL
 |  . ||||.. |..         .  ...||||||  ||||||....  ..|..|   . ||....|| ||   .. ..|... |. .|..| .|
PdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-182 4.9e-36 119.6 In-house 112-296 (319) alignment 
Range on Protein: 2-182
Range on HMM: 112-296/319.0
PLSQTVTDFLRLIYDYRISTIVMLNdlskEDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTL
||  |. || |.|..|..||||.|     .|  | ||       .. | ..|    |.. .. | .|| .    |. | |. | || | .|   |.   |
PldntladfWrmiweyncstivllt....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl

LDFMNN---VTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILN--HLMAMS
. ....   .||.. .  ...|||  |||||||. |... ||... |. |||...|. || .  ...|.| .||..|  |   ||.. |
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-182 7.8e-36 119.0 In-house 76-260 (284) alignment 
Range on Protein: 2-182
Range on HMM: 76-260/284.0
PLSQTVTDFLRLIYDYRISTIVMLNdlskEDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTL
||  |. || |.|..|..||||.|     .|  | ||       .. | ..|    ||| .. | .|| .    |. | |. | || | .|   |.   |
PldntladfWrmiweyncstivllt....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdl

LDFMNN---VTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILN--HLMAMS
. ....   .||.. . ....|||  |||||||. |... ||... |. |||...|. || .  ...|.| .||..|  |   ||.. |
mrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-177 9.4e-36 117.9 In-house 93-274 (515) alignment 
Range on Protein: 1-177
Range on HMM: 93-274/515.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS--SIYWDEANPNIK--QPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQ
.|.  .| || ||.......||.|...|...| .  . || .   .      ...... .      . |.|.. . ...| .  |.|  | .  .    .
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhts

TLLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
.|| .. .| ...|    |...||. |||||||.. .. .. . .  ..||||..|. .| .  ...|  |.| . | ..  
sllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-182 5.3e-35 116.1 In-house 98-291 (325) alignment 
Range on Protein: 1-182
Range on HMM: 98-291/325.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKED-ASSIYWDEANPNIKQPFSMNV-LDTV-ESEHWTERTLELKHRKN--TRIIQHFQFLSWKEVDSVDFY
.||..|. |. ||..|.| | .|.|| | ...   ..|| .   . |.  ...| | |. |   .  | |..|  |.  || .. ||. ||...    . 
aPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrp

QTLLDF-------MNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMS
 ||. .        . ||..  . .|.|||| .||||||||  .   |...  |  ||.|. || ||.|  .|... . | |.|  |   .  .
atlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-179 6.6e-35 115.5 In-house 94-278 (287) alignment 
Range on Protein: 2-179
Range on HMM: 94-278/287.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS--SIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK---NTRIIQHFQFLSWKEVDSVDFYQ
|...|. .| .|| | ....|||| ..  .| .    || | .  .  ......|.   .....||.||.|...   ... .. .|. .|..   |  .|
PmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq

TLLDFMNNV--TSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
| |  ...   | .. |.....||| ..|||...|| . . ... . | ..||||..|  |    ...|  | ||  . |. . .
tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-178 9.2e-35 115.0 In-house 81-267 (274) alignment 
Range on Protein: 2-178
Range on HMM: 81-267/274.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPN-I---KQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFY
||..||.|| |.||  ... |||| .|. ..    . |. .|.   |    . ....| ..|| .... |.| ||. ...| ..|. . .| . .| |  
PlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPdda

QTLLDFMNNVTSQQ---GGD-SPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
.||||....| ...       .||.|||  |.||||.|  ..... ||. |  |||..||  || |   |.|. | |.| .|.| . 
ntlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-178 3.5e-34 112.9 In-house 243-437 (440) alignment 
Range on Protein: 1-178
Range on HMM: 243-437/440.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSkEDASSIYWDEANPNI-KQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWK---EVDSV----
|||  || || ||..|||||||.|||.|  . . ||||      .   ||..    . . .    ||||||....   |. |.  .|    . | |    
mpldstvldfwrlvhdyristiimlnqln.dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwiqsdgvqsqe

---DFYQTLLDFMNNVT-------SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
   |    |.|.....        |. |   |.||||| |.  .|||| |  ||.||. . |.|||| .. ||    ... .| || |||..| | 
qcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykllthh
subfamily_CG7180_pd Subfamily CG7180 2-180 7.7e-34 111.7 In-house 93-291 (296) alignment 
Range on Protein: 2-180
Range on HMM: 93-291/296.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA-SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR------------KNTRIIQHFQFLSWKE
|  .|| .| ||.||  ||..|.| .          || .   .  ... .... . .  . . ||. |...             .|||...||.  |. 
pkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWel

VDSVDFY-QTLLDFMNNVTSQQGGD------SPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
 |.| .  ..|..... | . ..        .||.|.. .|..|.||.. . ..|...| |. ||||. || ||..  |.... |.|| .| .|.. . 
edkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-183 3.2e-32 106.4 In-house 93-297 (301) alignment 
Range on Protein: 2-183
Range on HMM: 93-297/301.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIK--QPFSMNVLDTV-----------------ESEHWTERTLELKHRKNTRIIQH
|. .|..|| |||.... ..|||. .| ..  . .  || ... . .   ||.. . ..                   ..  .||... |..|... .  
pmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlq

FQFLSWKEVDSVDFYQTLLDFMNNVT--SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
.|  .| .   |  ..| |  ...|    |. | .||.||| ..|.|.||.| | . |.|   |  |||||..||.|.    ... || |   | ...  
lqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

MAMSQ
... .
lqlns
subfamily_PTPN12_pd Subfamily PTPN12 2-182 1e-31 104.9 In-house 91-280 (290) alignment 
Range on Protein: 2-182
Range on HMM: 91-280/290.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNI--KQPFSMNVLDT-VESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQ
||..|..|| |.|...... .||.  .   .      || | . .    ..|.... .    .. .. |||.....|..|... |.. .| . .     .
PLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssak

TLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEV---EDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMS
.||.....| . |   |.|..|||  ||||||. ... .  ..|.    .. .|||..|  ||..   ..|. | |.| |. . .|.  .
sllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPRG_pd Subfamily PTPRG 2-189 1e-31 104.8 In-house 99-296 (563) alignment 
Range on Protein: 2-189
Range on HMM: 99-296/563.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH--------RKNTRIIQHFQFLSWKEVDS
|| .|. || |.|.. . ..|||. .| ..      .|| . ..   . ....  ..      |.||| .|.        ... . ...... .| ....
plkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv

VDFYQTLLDFMNNVTS-QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQENtLQS
 ..    | |..     ..    |..||| .||||||...|..  | |.. |.||.||...| .|     ..|. |.|   . .|  ..|  ... |..
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete.lla
subfamily_PTPN23_pd Subfamily PTPN23 2-175 8.3e-31 101.9 In-house 91-276 (288) alignment 
Range on Protein: 2-175
Range on HMM: 91-276/288.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS--SIYWDE--ANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFY
|| .|. || ...|. . |.|||| . .. .    . || |   ...  ...|. . .. |.|.. ||.|.|....  ... ..| |. || |.   .  
PlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasP

QTLLDFMNNVTS-----QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA-VDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
.|||.|...| |     |.  . |..|||. ||||||||..|   . .||...  .|. |.|. ||..   |.|  | .| .| . 
etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPN3_pd Subfamily PTPN3 2-176 4.2e-30 99.6 In-house 92-273 (280) alignment 
Range on Protein: 2-176
Range on HMM: 92-273/280.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIK-QPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQ
||..|.||| ..... ..|.|||| .|  .       || | . ...   ||...  . |.. .  | | ||...  . | | ..|.|.| . .  |  .
PlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsa

TLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKL-CYRILN
 .|.|...| ... | ..||.|||  |.|||||. .....|  .| ...| . .||. .|     ..|. . ||. |  ||.
dflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2-179 1.4e-29 98.0 In-house 72-264 (270) alignment 
Range on Protein: 2-179
Range on HMM: 72-264/270.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPN-IKQPF-SMNVLDTV--ESEHWTERTLELKHRKNTRIIQHFQFLSWKE------V
||  |...|.|.|.. . ..|||. .|  .  .  . || . . . .|  .  ..|| .    .| .  . |.|... ..| . ||.. .| .       
PlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpree

DSVDFYQTLLDFMNNV--TSQQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
||.   . ||  ...|  ....    .|.|||| .||||||.. .. ...  || .  ||| .|...||.|  ...|  | |.. |. . . .
dsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPN9_pd Subfamily PTPN9 2-175 2.8e-29 97.1 In-house 93-286 (297) alignment 
Range on Protein: 2-175
Range on HMM: 93-286/297.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQ--PFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFY
|| .||.|| |.... .. .|||   .  .     . ||.. . . ..   .|.......|.|....|.||.|.   ...| . ||||||| .    .  
plkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssa

QTLLDFMNNVTSQQG--------------GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
..|||....| ..|.               . |..|||  |.|||| |. . .||..|| .. |||.. || ||     .||  | |..||  .
aslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-180 4.9e-28 93.0 In-house 92-277 (281) alignment 
Range on Protein: 2-180
Range on HMM: 92-277/281.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIK-QPFSMNVLDTVESEHWTERTLEL-KHRKNTRIIQHFQFLSWKEVDSVDFYQT
|. .....| ........|.|||.    ...      || . | ..|   . .. . . |.... ||...| ..  .|| ........| .    .  . 
PvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattke

LLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE-DAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
||.| ..|.. .    . |...||  ||||||..  .   ....| |   .|| ..|. ||..   |.|..  |.  |... . . 
llefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN6_pd Subfamily PTPN6 3-184 1.4e-27 91.5 In-house 107-302 (306) alignment 
Range on Protein: 3-184
Range on HMM: 107-302/306.0
LSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQ-PFSMNVLDTVESEHWTERTLELK---HRKNTRIIQHFQFLSWKEVDSVDFYQ
|..||.|| |....     |||.        .  . || ... . .    |.. ..  . .... |.| ..   . |..| . ...| || . .     .
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg

TLLDFMNNVTSQQGGDS-----PVLVHCLNGVGRTGVFCVVKMCLDQLEV---EDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQE
..|||...|...|   .     |..||| .|.|||| | |. . |...|    .  .|. ..|| .|.   ...|  . ||. |..... .  ...
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_PTPN13_pd Subfamily PTPN13 2-180 3.7e-27 90.3 In-house 85-270 (273) alignment 
Range on Protein: 2-180
Range on HMM: 85-270/273.0
PLSQTVTDFLRLIYDYRISTIVMLN-DLSKED-ASSIYWDEANP---NIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDF
|| .||.|| ..... . . |.|.  .  |.      || | .     ... . ...|.... . .. |.|..|. .  ..| ..|..| .| . .    
PlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss

YQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
 . || |. .| . |   .|..|||  |.||.|.. .... |. .| .  .|| .||. ||.    ..|. . | ..|... ... 
aaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0051429 (Phosphotyrosine protein) phosphatases II 2-179 5.6e-27 90.5 In-house 30-225 (272) alignment 
Range on Protein: 2-179
Range on HMM: 30-225/272.0
PLSQTVTDFLRLiYDYRISTIVMLNDLS--KEDASSIYWD------------EANPNIKQPFSMNVLDTVESEHWTERTLELK---HRKNTRIIQHFQFL
||  |. || || ....|.|||.| ...  . .  . ||             .| .     ... .| ..  .... |.|.|.   . ...| . |....
plpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhyt

SWKEVDSV-DFYQTLLDFMNNvtsqqggDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVD--------VFQIVKALRHDNFQMIQSLEDYKLCYRIL
.|       . . .||.....       . ||||||  |..|||..... ..| ... |. ||        ....|. ||    ...|. | |. .|..|
dwpdhgvpqeallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

NHLM
 .|.
lell
0041856 (Phosphotyrosine protein) phosphatases II 2-179 1.5e-26 88.5 In-house 42-171 (182) alignment 
Range on Protein: 2-179
Range on HMM: 42-171/182.0
PLSQTVTDFLRLIYDYRISTIVMLNdlskedaSSIYWDEANpnikqpfsmnvldtvesehwtertlelkhrknTRIIQHFQFLSWKEVDSVDfYQTLLDF
|| .|| ||||......|.|||.|.       .  || |                                  .| . ....|.|   .  |  ..||||
pllstvadflrmlkelgittivnlt.......eelywpell................................erlgiqylylpwpDhgvpd.ldelldf

MNNVTSqqgGDSPVLVHCLNGVGRTGVFCVVKMCLDQlevedAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
.. | .    . ||||||  ||||||....  ... .      |.....|| .|   ..|..... | .....| .|.
ieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPRN_pd Subfamily PTPRN 2-174 1.9e-26 87.4 In-house 108-287 (297) alignment 
Range on Protein: 2-174
Range on HMM: 108-287/297.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDASSI--YWDEANPNIKQPFSMNVL-DTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQ
||..||.|| .....  .  ||.|  |..|. .    || .   .. . . .... . . .. .  |.. ||    ..|| .  | ||||.| .     .
plastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasak

TLLDFMNNVT-SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEV-EDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRI
.||.|   |  | .|  .|..||| .|.|||||.... . |..|      .|.   .. || .  ..... .......  
sllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
0036282 (Phosphotyrosine protein) phosphatases II 4-173 2.9e-26 87.6 In-house 27-164 (174) alignment 
Range on Protein: 4-173
Range on HMM: 27-164/174.0
SqtvtdFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEanpnikqpfsmnvldtvesehwtertlelKHRKNTRIIQHFQFLSWKEVDSVDFYQtLLDF
.     |........|.|.|||...   .      || |                             ..   .| . ....| |      |. . ||.|
a.....fwemlkelgittvvmlleekelglykcinywpe.............................lredlerlgiqylylpwpDhgvpdlsi.llef

MNNVTSQQGG--DSPVLVHCLNGVGRTGVFCVVKMCLDQLEvEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYR
.. | . .    . ||||||  ||||||....  ..| .|. |..||....|..||  . .|.|. . |. .| 
vkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
PTPc_DSPc_SM00012 78-176 8e-26 85.7 In-house 2-104 (105) alignment 
Range on Protein: 78-176
Range on HMM: 2-104/105.0
IQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGD---SPVLVHCLNGVGRTGVFCVVKMCLDQLEVE-DAVDVFQIVKALRHDNFQMIQSLEDYKLCYR
..|.....|..    .  . .|.....| ...      .||.||| .||||||.|... ..|.||| | . ||.|||||.||.   .|.|..|.|  .||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ILN
.|.
all
subfamily_PTPN14_pd Subfamily PTPN14 2-179 1.6e-24 81.4 In-house 101-296 (300) alignment 
Range on Protein: 2-179
Range on HMM: 101-296/300.0
PLSQTVTDFLRLIYDYRISTIVMLNDLS--KEDASSIYWDEANPNIK----QPFSMNVLDTVESEHWTERTLELKHR--KNTRIIQHFQFLSWKEVDSVD
|| .||.|| .....  .. |||| .      . |  |. . . . |    . | .    . .|.  . ..|.|||   |. | . |.|.  | . .  .
PleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPe

FYQTLLDFMNNVTSQ----------QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
  .. |.....| |           .  . ||||||..|||||||  .. . .  || .. .|. .... ||.    ..|.|  ||  |..| . .
DvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2-203 1.7e-24 81.1 In-house 99-301 (439) alignment 
Range on Protein: 2-203
Range on HMM: 99-301/439.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAssiYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR----KNTRIIQHFQFLSWKEVDSVDFYQT
|  .|. || ||... . .||||| .| .      ||   .  .    .. |   .|  ... | . .  .    .. | . .|....| . .       
pkkettddfwrlviekktvtivmltnlvesyk...ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

LLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSqeNTLQSGQEFDM
.|||.  . | .      ||.|||  ||||||    . ..|.|| .|. ||.  ||| ||..  ||.|.| .| . |  .   .     ..  . .||  
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyG..diavtidefkk

EKDDGLSE
| . |.| 
efnagfst
0043147 (Phosphotyrosine protein) phosphatases II 2-172 6.3e-24 80.0 In-house 28-154 (172) alignment 
Range on Protein: 2-172
Range on HMM: 28-154/172.0
PLSQTVTDFLRLIYDYRISTIVMLNDLskedassiywdeanpnikqpfsmnvldtvesehwtertlELKHRKNTRIIQHFQFLSWKEVDSVdFYQTLLDF
||. |. ||.|..... |..||.|..|                                       ..   . .| . ....|.|   .     . ||.|
plrntladfwrmlkelgithivnltel.......................................lydpellerlgiqylylpwpDhgvp.llelllef

MNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLdqleveDAVDVFQIVKALRHDNFQMIQSLEDYKLCY
.. . .  ..  . ||||||  ||||||....  ..|        ......|. .|.  ....|. . |...|
lefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
0049772 (Phosphotyrosine protein) phosphatases II 2-180 1.2e-23 79.8 In-house 92-281 (314) alignment 
Range on Protein: 2-180
Range on HMM: 92-281/314.0
PLSQTVTDF----------LRLI--YDYRISTIVM---------------------LNDLSKEDassiywdeanpnikqpfsmN------VLDTVesehw
||. || ||          .|..  .|... .|||                     |..|.                      |      . .       
pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...................neptaadlellk.....

tERTLELKHRKNT-RIIQHFQFLSwKEVDSVDFYQTLLDFMNNVtsqqGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVeDAVDVFQIVKALRH--DNF
 |.. . .. ...     .. .    .... .... .|.|....      ..||||||  |.||||.|.|. ... .| | .. .... |.. |.   |.
.eelydpelferlgikylripvpD.gsaplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp

QMIQSLEDYKLCYRILNHLMA
 .|..||.|  ....|.... 
gfieqleqyefilealleylk
0051082 (Phosphotyrosine protein) phosphatases II 7-174 3.9e-23 77.1 In-house 22-148 (151) alignment 
Range on Protein: 7-174
Range on HMM: 22-148/151.0
VTDFLRLIYDYRISTIVMLNDLSKEDASSIYWDEANpnikqpfsmnvldtvesehwtertlelkhrkntRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVT
  |||.|.... |.|||.|...   .    |. |..                                 . . |...|.|.. .  ......|.|.. . 
ladflellkelgiktivnlrseeergycpeylpelg.................................ievlhipildwpdpglplsfdavleflelll

SqqGGDSPVLVHCLNGVGRTGVFCVVKMCLDQlevedaVDVFQIVKALRHDNFQMIQSLEDYKLCYRI
.   .. ||||||  |.||||..... ..| .      |....... .|  .. ..|. . . .... 
d..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 2-173 8.1e-23 76.2 In-house 17-144 (152) alignment 
Range on Protein: 2-173
Range on HMM: 17-144/152.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWdeanpnikqpfsmnvldtvesehwtertlelkhrkntriiqHFQFLSWKEVDSVDFYQTLL
|...|. ||.|..... |.|||||..|.  .      |.                                         ....| |      |. | ||
pgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwpDhgvpdlsqlll

DFMNNVTS-QQGGDSPVLVHCLNGVGRTGVFCVVKMCLdqleveDAVDVFQIVKALRHDNFQMIQSLEDYKLCYR
...  .   ..  . ||||||  ||||||....  ..|        |.....|. .|  . ..... . ....| 
flllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 2-177 1e-22 76.2 In-house 31-171 (176) alignment 
Range on Protein: 2-177
Range on HMM: 31-171/176.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS--SIYWDE-ANPNIkqpfsmnvldtvesehwtertlelkhrkntriiqHFQFLSWKEVDSVDFyQTL
|| .|. |||.......|...|.|...   .      ||.|  ...|                                  ....| | . .  |. . |
plprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................................qylhlpwpDhgvpdl.ell

LDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVvkmcLDQLEVEDAVDVFQIVKALRHDNF-QMIQSLEDYKLCYRILNH
|.... . ...  . ||||||  |.||||....    .. || |  ..|..... .|   . ...|. | |. .|. . .
lellefirealkeggpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2-177 1.3e-22 75.1 In-house 80-257 (267) alignment 
Range on Protein: 2-177
Range on HMM: 80-257/267.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDaSSIYWDEANPNIKQPFSMNVLDTVESE--HWTERTLELKHRKNT-RIIQHFQFLSWKEV-DSVDFYQT
||..|.|||| .| |.....||.|    ...    .|     . |.   . |  ..| |   .   ||||| .... . .  . .  |.   .   . . 
plkntitdfltvihdqkvpvivlltkvftdn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkp

LLDFMNNVtSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
|.  . .    . |. |..|.| .||||.| | |..  |...  |. .|.|. .. .|.    .....| |  ....| .
lfgilakn.qlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN1_pd Subfamily PTPN1 2-185 2.5e-22 73.9 In-house 79-278 (290) alignment 
Range on Protein: 2-185
Range on HMM: 79-278/290.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANP--NIKQP---FSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSV
||..||. | ..... .  ..|||| .  ..      || . .   ...     ...... . .....| |.|||.    ..|| | || ...| .    
PlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvp

DFYQTLLDFMNNVT---SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA---VDVFQIVKALRHDNFQMIQSLEDYKLCYR-ILNHLMAMSQEN
.  ...|.|. .|    | .    |...||  |.||.| ||.|  || ..| .|    ||. . . .||.  . .||  .  .. |  ||.    . ...
espaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgds
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-176 6.1e-22 72.7 In-house 88-274 (287) alignment 
Range on Protein: 2-176
Range on HMM: 88-274/287.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSkEDASS---IYWDEAN-PNIKQPFSMNVLD-TVESEHWTERTLELKHR--KNTRIIQHFQFLSWKEVD----
|.. || || |.... | ......     |.|      || | . |     .|. .|| .. . ... |.| | .   ...|... ...||| .      
Piaatvrdfwravletrsasvitmtrev.eearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt

SVDFYQTLLDFMNNVTSQQGG--DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILN
.| . .  ||  ...  .. .    |..||.  |.||.|..  . .....||    ||| ..|  ||     ..|.   ..| |  | 
avglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-172 9e-21 69.2 In-house 53-232 (237) alignment 
Range on Protein: 2-172
Range on HMM: 53-232/237.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEAN-PNIKQPFSMNVLDTVESEHWTERTLELKHR---KNTRIIQHFQFLSWKEVDSVDFY
||  .  || ..... . | ||||  | .        || ... |.    ... .    |   .| |.| | .|   |. |.|. .|| || .    .  
plesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqt

QTLLDFMNNVTSQQGG---DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCY
 .|| |  |.  .       .| ..||  ||||||.| |.   | | . .  ||... |...  |   .||. ..| . .
aallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2-173 7.6e-20 65.9 In-house 12-197 (198) alignment 
Range on Protein: 2-173
Range on HMM: 12-197/198.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDT-VE-SEHWTERTLELK----HRKNTRIIQHFQFLSWKEVD--S
|| .|..|| .....     |||.||  |.     ..||  ..    .  |..|    .     .|  .| |         || | |.|| ||||     
plretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpn

VDFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE--DAVDVFQIVKALRHDNFQMIQSLEDYKLCYR
| ..  ..    .|.   .|  |.||.||| .| | ||||  . . .   |      ||.|.. | ||     .| ||. |.. |.
valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2-173 8.3e-20 65.8 In-house 13-198 (199) alignment 
Range on Protein: 2-173
Range on HMM: 13-198/199.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDT-VE-SEHWTERTLELK----HRKNTRIIQHFQFLSWKEVD--S
|| .|..|| .....     |||.||  |.     ..||  ..    .  |..|    .     .|  .| |         || | |.|| ||||     
plretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpn

VDFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE--DAVDVFQIVKALRHDNFQMIQSLEDYKLCYR
| ..  ..    .|.   .|  |.||.||| .| | ||||  . . .   |      ||.|.. | ||     .| ||. |.. |.
valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0044763 (Phosphotyrosine protein) phosphatases II 5-181 9.9e-20 66.4 In-house 35-173 (178) alignment 
Range on Protein: 5-181
Range on HMM: 35-173/178.0
QTVTDFLRLIYDYRISTIVMLNDLSK---EDASSIYWDEANpnikqpfsmnvldtvesehwtertlelkhrkntRIIQHFQFLSWKEVDSVDFYQTLLDF
.   |.|.|.... |..||.|..      ..    ...||.                                    .|. .  ... |. .. . ...|
lppaddlellkelgithivnlteelelgflkcdpywpeeag.................................iqylhipipDhgvpdllehflefvef

MNNVTSQQGgdSPVLVHCLNGVGRTGVFCVVKMCLDQlevedAVDVFQIVKALRHDNFqMIQSLEDYKLCYRILNHLMAM
.... ...|  .||||||  ||||.|....  ... .      ........ .|   . .... .... .|..  .|...
ieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 115-177 5.6e-19 62.8 In-house 321-383 (392) alignment 
Range on Protein: 115-177
Range on HMM: 321-383/392.0
VLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
.||||| | |||||||    |. |.   |.||.|| || || | .|..|. |.| . | . . 
ilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvire
0048076 (Phosphotyrosine protein) phosphatases II 51-178 9.4e-19 63.0 In-house 36-142 (145) alignment 
Range on Protein: 51-178
Range on HMM: 36-142/145.0
MnvldtvesehwtertlELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDqlevEDaVDVFQI
.                    .  .| . ....|.|   .  |....||.|.. . . .  . ||||||  ||||||....  ..|     .. |.....
l................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

VKALRHDNFQMIQSLEDYKLCYRILNHL
.. .|   ...... . .. .|. . .|
lelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 66-173 3.7e-18 61.1 In-house 22-139 (144) alignment 
Range on Protein: 66-173
Range on HMM: 22-139/144.0
TLELKHRKNTRI---------------IQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLdqleVEDaVDVFQI
  .||. . | .               . ....|.|   .  |... ||.|.. . . .  . ||||||  ||||||....  ...    ... ......
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleea

VKALRHDNFQMIQSLEDYKLCYR
.. .|  ....... . .. ...
lalvrsrrpgavpnpgqlrfLle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 6-171 6.9e-18 59.7 In-house 63-232 (239) alignment 
Range on Protein: 6-171
Range on HMM: 63-232/239.0
TVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQpFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDF
.  || |.... |   ||||  | .        || ..  .  . . . .  |     .  ||. . .  . . | . ...|  | .    ..  ..| .
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn.lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl

MNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLC
  ..| .   |  | ..||  |||||| | |.   | | . . .||.|. |||.| |  .|.|. |.| . 
rrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2-181 7.2e-18 59.6 In-house 90-273 (288) alignment 
Range on Protein: 2-181
Range on HMM: 90-273/288.0
PLSQTVTDFLRLIYDYRISTIVMLNDLS-KEDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQ------FLSWKEVDSVDF
||  |.  . ... .  .  ||||..|  |    |  .   .   |  .  .  .. ..    ......   .... ... .      .| |..    . 
PlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen

YQTLLDFMNNVtsqQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAM
|.. | ... .   .  . |..||. .|||||| . .. . |..| ..| . . .... || . |. ||.   |   .|.. . ...
ylsplrllevl...kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 6-170 7.6e-18 59.5 In-house 64-232 (239) alignment 
Range on Protein: 6-170
Range on HMM: 64-232/239.0
TVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQpFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDF
.  || |.... |   ||||  | .        || ..  .  . . . .  |     .  ||. . .  . . | . ...|  | .    ..  ..| .
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn.lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl

MNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKL
  ..| .   |  | ..||  |||||| | |.   | | . . .||.|. |||.| |  .|.|. |.| .
rrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-172 1.1e-16 55.3 In-house 102-276 (290) alignment 
Range on Protein: 2-172
Range on HMM: 102-276/290.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVE---SEHWTERTLELKHRKNT--RIIQHFQFLSWKEVDSVDF
.| .|| |. |.. . ....|||| .| ..     . |. | . ..    .. || . |    ..   .|| ......    ...|..  || .      
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals

YQTLLDFMNNVTSQQGgdsPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCY
  .||  .  .    |   || |||  |.|||| |  ....|. |    ..|. ..|.|||.   . .|   .| .  
tlallrtlrilrkasG...pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2-167 1.5e-16 55.0 In-house 98-269 (301) alignment 
Range on Protein: 2-167
Range on HMM: 98-269/301.0
PLSQTVTDFLRLIYDYRISTIVMLNDLS--KEDASSIYWDEANPNIKQ--PFSMNV--LDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSV
||..|  ||  ..  | . .||||      .|.  . |     ..  .   |....   ... ... ..||||..    . .|| . |.|. .| . .  
PlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvP

DFYQTLLDFMNNVTSqqgGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLED
  .  | |.|. |      . |..||| .|.||.  |   ..   ..| .  ... . .| ||.. .. .|  . 
kshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4-177 2.4e-14 47.7 In-house 91-267 (281) alignment 
Range on Protein: 4-177
Range on HMM: 91-267/281.0
SQTVTDFLRLIYDYRISTIVMLNDLS---KEDASSIYWDEANPNIK-QPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLL
 .| .|| |.|..   ..|||| ..    .| ..  .  .|   .. . .|..  |.   .      |.| .  .||.| |. .  | . .  .  . .|
ketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevml

DFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA-VDVFQIVKALRHD-NFQMIQSLEDYKLCYRILNH
  . .. ..    .| ..||  ||||.| .  |...|. .    .  |. |||  ||       .|.|..| | ...|  
kilrkirars...tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 65-177 3e-14 47.7 In-house 165-275 (307) alignment 
Range on Protein: 65-177
Range on HMM: 165-275/307.0
RTLELKHRKNTRIIQHFQFLSWKEVDSvdfYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQL-EVEDAVDVFQIVKALRHDNFQMIQ
 ||...  ...| |||.|.  | .       |. |  .| . . ..   ||.|||  ||||.|    . .  |.. . ..  |. ..|. || .    ||
ttlkvdwaqksrtiqhlqwenwpdrgv...pqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq

SLEDYKLCYRILNH
.   |   .|.| .
teaqylylhrvlle
subfamily_CG42327_pd Subfamily CG42327 107-177 3e-14 47.4 In-house 242-313 (319) alignment 
Range on Protein: 107-177
Range on HMM: 242-313/319.0
SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE-DAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
...    |. ||| .||||||.     . . .||    .||. |.|  .|.|  . ... | |.. |..|  
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 6-183 4.4e-14 47.3 In-house 79-261 (290) alignment 
Range on Protein: 6-183
Range on HMM: 79-261/290.0
TVTDFLRLIYDYRISTIVMLNDLSKEDAS------SIYWDEA-NPNIK-QPFSMNVLDTVESEHWTERTLELKHRKNTR-IIQHFQFLSWKEVDSVDFYQ
|. .|. .. . ..  .||| . ....|       . |  |. . ..| . ....  . .. .   .|.|..|. ..    ..| .. .|...   .  .
tiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtk

TLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMCLDQLE-VEDAVDVFQIVKALRHDNFQMIQSLEDYKLC-YRILnhlMAMSQ
|||. ...|  ..   .||.||| .|. |  ..  ...    .   ...| . ...||||.   ..|.| ...    . |.   . . .
tllsliqkvkask...tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...llaie
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 75-179 1.1e-12 42.0 In-house 180-285 (302) alignment 
Range on Protein: 75-179
Range on HMM: 180-285/302.0
TRIIQHFQFLSWKEVDSVDFYQTLLDFMNNV-TSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYR
. ...   .  ||.    . | .|   . .| .... .|.....   ||.|| |.| .. . ...|. .... . .|||..| .  ....||. |   |.
svlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyi

ILNHLM
.|. ..
alllyi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2-177 1.4e-12 41.9 In-house 104-288 (305) alignment 
Range on Protein: 2-177
Range on HMM: 104-288/305.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK-------H-RKNTRIIQHFQFLSWKEVDS
|| ||. .|  .. . ..  ||||    .      . ||  |. . ..  |  |.. |   .  ||  |..       .  ...  ..|.|.  | .   
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv

VDFYQTLLDFMNNVtsqQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQL-EVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL-NH
     | |...  .   .|   |..|||  |.||||    ..  |... |  ..  . ..||||| .    ||.  .|   .|.. |.
ppckltslellsai...rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 5-156 3.8e-12 40.8 In-house 39-198 (255) alignment 
Range on Protein: 5-156
Range on HMM: 39-198/255.0
QTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLEL----KHRKNTRIIQHFQFLSWKEVDSVDFYQTL
 ||  |.. |   . ...||| |.  |.    | |.     . ..   .||  |  | .   ||||.     ..|.|. ..|...  | |  . .  . .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFMNNVTSQqggdSPVLVHCLNGVGRTGVFCVVKMCLD----QLEVEDAV--DVFQIVKALRH
|  .  |.       .|.||| .|.||.  | .. .       .|.  ..|  |  .... ||.
lnilkvvrds....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 103-174 2e-11 38.3 In-house 219-290 (297) alignment 
Range on Protein: 103-174
Range on HMM: 219-290/297.0
NNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRI
. . ...  . ..||||  ||||.||    .. |..|  .   ||  |.. ||.   ...|.|| ..|.| .
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_hpo-7_pd Subfamily hpo-7 3-140 7.6e-11 36.4 In-house 43-186 (263) alignment 
Range on Protein: 3-140
Range on HMM: 43-186/263.0
LSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH----RKNTRIIQHFQFLSWKEVDSVDFYQ
| ||.  |.. |   . ...||| |   |  .  | |.     . ..   .||  |   .    .||||      .|.|. ..|...  | |.  .   .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

TLLDFMNNVTSQqggdSPVLVHCLNGVGRTGVFCVVKMCLD----QLE
  |  .. ..       .. ||| .|.||.  | |. .       .|.
eilnilkvarns....kslvvhcstGiGrsaafsvaElvyqkmirsld
subfamily_ptpA1_pd Subfamily ptpA1 2-139 7.9e-11 36.3 In-house 97-256 (418) alignment 
Range on Protein: 2-139
Range on HMM: 97-256/418.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEAN--------PNIK---QPFSMNVLDTVESE--HWTERTLELKHRKNTRIIQHFQFLSW
|| .|..|| |.... |   ||||.  |..       || |           | .     .|..... ..        | . |    .|| | ..|.  |
plpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegw

KEVDSVDFYQTLLDFMNNVTSQQG-------GDSPVLVHCLNGVGRTGVFCVVKMCLDQL
 . .  |. | . ... ..| .|         . |..|||  |||||| ||   . . .|
pdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2-176 1.6e-10 35.4 In-house 83-267 (285) alignment 
Range on Protein: 2-176
Range on HMM: 83-267/285.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQPFSMNV-LDTVESEH-----WTERTLELKH--RKNTRIIQHFQFLSWKEVDS
|| .|..|| ..||. .|. ..||  | .   .  ..|. |   .. .    .. |  .. |      .   |.        .   ..| |   | .  .
plpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla

VDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILN
 .  . .... . |   .  . |. |||  |||||  |  .  .  ..  .  .....||. .|   || .||  .. . | .| 
pedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
0038934 (Phosphotyrosine protein) phosphatases II 66-153 2.4e-10 35.9 In-house 69-157 (194) alignment 
Range on Protein: 66-153
Range on HMM: 69-157/194.0
TLELKHRKN-TRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQqGGDSPVLVHCLNGVGRTGVFCVVKMCL-DQLEVEDAVDVFQIVKA
. . .. ..    . ...| .  .| | . ... ||... ....   .  |.|||  |.||||....  .    .. .|.|.. |.... 
yYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRp
subfamily_egg_pd Subfamily egg 2-205 7e-10 33.1 In-house 91-292 (307) alignment 
Range on Protein: 2-205
Range on HMM: 91-292/307.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKEDASSIYWDEANPN--IKQP--FSMNVLDTVESEHWTERTLELKHR---KNTRIIQHFQflsWKEVDSVDF
||  || || |...  ..  ||||.   . .    ||  |. .  .  |  . .. |.  .      |  .||     .. | ..|.|   .    | | 
plkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnnssdv

YQTLldfmNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEdAVDV---FQIVKALRHDNFQMIQSLEDYKLCYRilnhLMAMSQENTLQSGQ
|  |    . .   .    ||.|.. .|| .....  ... | .|     .      . |. ||      ..|   | . ||    |...   . . | .
yspl....rvlrklrnlskpvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyr....lvlfffrdvigsak

EFDMEKDDGLSESV
|.|.. .  | | .
eldvdyerwleers
PTPc_motif_SM00404 59-168 8.1e-10 33.7 In-house 37-137 (140) alignment 
Range on Protein: 59-168
Range on HMM: 37-137/140.0
SEHWTertlelKHRKNTRIIQHFqFLSWKEVDSVDFYQTLLDFMNNVTSQQGgdsPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHD
.  .|      |. .. .|.|       .. . ... . .|||..|.....|    |||||  || |.. ....  |. .||....|.....  .     
evslt......kensgfqilqip.lddnekdklskyldkvldfienaekkgg...kvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiisp

NFQMIQSLEDY
|.. ...| .|
nlnfvrqLiey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2-89 1.2e-09 32.5 In-house 84-177 (297) alignment 
Range on Protein: 2-89
Range on HMM: 84-177/297.0
PLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSM------NVLDTVESEHWTErtLELKHRKNTRIIQHFQFLSWKEV
|||.|| || .|...  . .|||.  | ..       || ... . ..  ..      .. |  .  . ||  |.| .|...| ..| ||||| . 
plsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvilte..lqliyrsesrvvrhvqflswpdh
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 98-183 2e-09 31.7 In-house 247-348 (350) alignment 
Range on Protein: 98-183
Range on HMM: 247-348/350.0
LLDF-MNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEV-------------E-DAVD-VFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAM
|.|  . .  ...   ||.||||  ||||||... . . | ..|.                  | ...||. ||.   .|.|.|. .  .|  | .. |.
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaL

SQ
..
rk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 72-175 2.3e-09 31.1 In-house 184-282 (302) alignment 
Range on Protein: 72-175
Range on HMM: 184-282/302.0
RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSleDYKLC
.|  . .. ..| .| .  . .  .| || ..   | .     ||||| .|||||| .  .|  ..    ..  |. .||. .|.  .  .|.  . .| 
kkvkktvdilafsawpdhGapkeaytaldilkfcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd..eqqli

YRIL
| .|
ylll
DSPc Dual specificity phosphatase, catalytic domain 74-168 2.3e-09 32.2 Pfam-A 36-130 (133) alignment 
Range on Protein: 74-168
Range on HMM: 36-130/133.0
NTRIIQHFQFL--SWKEVDSVDFYQTLLDFMNNVtsqQGGDSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDY
..  |....      .| . ... . . .|....   .     |||||  |. |.. ....  |. ..|....|.....  .     |.. ...| .|
kkseieylripvedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 74-168 2.3e-09 32.2 In-house 36-130 (133) alignment 
Range on Protein: 74-168
Range on HMM: 36-130/133.0
NTRIIQHFQFL--SWKEVDSVDFYQTLLDFMNNVtsqQGGDSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDY
..  |....      .| . ... . . .|....   .     |||||  |. |.. ....  |. ..|....|.....  .     |.. ...| .|
kkseieylripvedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 76-179 2.9e-09 31.1 In-house 176-276 (312) alignment 
Range on Protein: 76-179
Range on HMM: 176-276/312.0
RIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
  ..|.|. || .    |  .| | ..  |  ..    ||. ||  |||||| .....  .  |      .| ..   ||.|  . .. . .|  . |..
sklnhyqwaswpdhgmpdscdtalrllsavkkdk...kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv

NHLM
 ...
lefl
subfamily_DSP1_pd Subfamily DSP1 90-169 6.5e-09 30.1 In-house 76-153 (163) alignment 
Range on Protein: 90-169
Range on HMM: 76-153/163.0
DSVDFYQTLLDFMNNVTSQQGgdsPVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYK
|    ... ..|...|....|    ||.||  |. |   .|..  |  .....|.| |  . .... . |.  ...| .|.
dislvfeeviefidevkkknG...kvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 73-176 1.5e-08 28.7 In-house 183-285 (305) alignment 
Range on Protein: 73-176
Range on HMM: 183-285/305.0
KNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGgdsPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVD-VFQIVKALRHDNFQMIQSLEDYKLC
...| ..|. .  | .       ...|.....  . .|   |. |||  |.||||   ...  ||||   . ..   .|.. .| .  . ||. ..| . 
ekarkvthyhwidwpdrgvpaadlailellekarpskg...pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv

YRIL-N
.... |
hqviln
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-110 1.7e-08 28.3 In-house 95-166 (392) alignment 
Range on Protein: 1-110
Range on HMM: 95-166/392.0
MPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDassiywdeanpnikqpfsmnvldtvesehwtertlelkHRKNTRIIQHFQFLSWKEVDSVDFYQTLLD
.| . .. || |.... ...||.|...| . |                                      . ...| .  |.|  | . |   .  .|| 
gpnaaslddfwrmvfqenvttiamvtklkegd......................................kgddartvaqfhftewPdkdvpkhtssllk

FMNNVTSQQG
|...| .. |
fikevkadfG
subfamily_DSP15_pd Subfamily DSP15 73-169 1.7e-08 28.7 In-house 37-136 (151) alignment 
Range on Protein: 73-169
Range on HMM: 37-136/151.0
KNTRIIQH--FQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYK
 . .....  ..... ..  |... . . . .. . . .  .  |||||| || |    .|.  |   .|. .||..| .  ... . ||   . |..|.
nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 98-180 2.4e-08 27.7 In-house 250-345 (349) alignment 
Range on Protein: 98-180
Range on HMM: 250-345/349.0
LLDFMNN-VTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLE--VEDAV----------DVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
|.| ..     ..   |..||||  | |||||.. . . |. ||   .. .           .. ||  ||   ..|.| | ..  .|  | . .|
liddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_DSP12_pd Subfamily DSP12 52-169 2.5e-08 28.5 In-house 29-140 (155) alignment 
Range on Protein: 52-169
Range on HMM: 29-140/155.0
NVLDTVESEHWtertLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQqggDSPVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQI
. . .| .|.      | |..|..   .. | |   |.| ...... .||...  ..   .  |||||  || |   ...   |  ..|..|.|... . 
thvlsvikeel....pehklkkgkvstkfiqilDepeediLshldeavdFieealee...egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvke

VKALRHDNFQMIQSLEDYK
.|   . |   .. |  ..
kkpeiepNegFleQLklfe
subfamily_DSP6_pd Subfamily DSP6 88-169 5.3e-08 26.5 In-house 69-151 (158) alignment 
Range on Protein: 88-169
Range on HMM: 69-151/158.0
EVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYK
.. | .. . . . .. .   .  .| |||||| |. |.   ..   |   .| ..|| |. .  |.    ||.... | |. 
dhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 112-174 5.6e-08 26.7 In-house 223-285 (310) alignment 
Range on Protein: 112-174
Range on HMM: 223-285/310.0
DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRI
  |..|||  |..|..| . .|. .|.|.  . ||. ...  |...... ||.  .| .  |.
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_DSP19_pd Subfamily DSP19 82-168 2.9e-07 24.9 In-house 62-146 (152) alignment 
Range on Protein: 82-168
Range on HMM: 62-146/152.0
QFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKM-CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDY
. |  .| | ...... |||.... |..     |||||  || |.  . .  .    .|..|.|... . ..   . |   |. |..|
eilDlpetdllsylkealdFieearskd...gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkey
subfamily_DSP11_pd Subfamily DSP11 63-162 6.3e-07 23.5 In-house 66-167 (178) alignment 
Range on Protein: 63-162
Range on HMM: 66-167/178.0
TERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTS-QQGGDSPVLVHCLNGVGRTGV-FCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQ
|.|  . |. ... .  .  . . .||.. . .... ..... .  ..  |. . ||| .|| |||   |   .  ...| |||...|. ..    .  .
tdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsleren

MI
 .
yl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 117-170 7.9e-07 23.3 In-house 2-55 (69) alignment 
Range on Protein: 117-170
Range on HMM: 2-55/69.0
VHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKL
|||  | |||| |  . . . ..  |  ||.|  |. .|     |.   ..| .
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 116-168 9.3e-07 23.2 In-house 2-54 (69) alignment 
Range on Protein: 116-168
Range on HMM: 2-54/69.0
LVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDY
.|||  | |||| |  . . . ..  |  ||.|  |. .|     |.    .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneiey
subfamily_PRL_pd Subfamily PRL 108-170 2.4e-06 21.7 In-house 86-147 (151) alignment 
Range on Protein: 108-170
Range on HMM: 86-147/151.0
QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVfqiVKALRHD--NFQMIQSLEDYKL
.. ..| | |||. |.||. |. .. .  . .. ||||..   ..  |..  | . .. ||.|| 
keepkstvavhcvaGlGraPvlvalalieaGmkyedavef...irekrrgainskqlkflekyka
PTEN_1 100-168 3.6e-06 21.9 In-house 119-188 (196) alignment 
Range on Protein: 100-168
Range on HMM: 119-188/196.0
DFMNNVTSQQGgDSPVLVHCLNGVGRTGV-FCVVKMCLDQLEVEDAVDVFQIVK-ALRHDNFQMIQSLEDY
.|.. . |..     |||||  |.||.|.  .   | . .| ...|.. ...   . .  .... . || .
sfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyf
subfamily_DSP14_pd Subfamily DSP14 89-168 6.2e-06 20.2 In-house 63-140 (157) alignment 
Range on Protein: 89-168
Range on HMM: 63-140/157.0
VDSVDFYQTLLDFMNNVTSQQGGdspVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDY
.. ......  | ...|. ..|    .|||| .|| |   .|..  |   .|  ..|  . . .. . . |    . | ||
aklakhfdevadkieevkkkggk...tlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidy
Y_phosphatase3 Tyrosine phosphatase family 50-134 8.7e-06 20.8 Pfam-A 70-146 (164) alignment 
Range on Protein: 50-134
Range on HMM: 70-146/164.0
SMNVLDTVES-EHWTERTLELKHRKNTRIIQHFQFLSWKEvdsVDFYQTLLDFMNNvtsQQgGdsPVLVHCLNGVGRTGVFCVVKM
...||.. .. .. ... |. ........ .... .  .|    . |...|. . .   .. |  |||.||  |  ||||.... .
nlpvlkeeaespeelaerlkeaeeaeeamaeayreilede...kkayrkvlealae...ee.g..pvlfHCtaGKDRTGvvaalll