Gene SpurPTP-sf1-16 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP093_AA protein Get Run
SpurP093_AA_33-241 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 106-247 1.5e-93 308.3 In-house 251-392 (392) alignment 
Range on Protein: 106-247
Range on HMM: 251-392/392.0
SVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS
 ...||||||||.. .|||..|..|.|||||||||||||||||| |.|||||.|||||||.|||.  |||||||||||||||||||||||||||||||||
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegds

VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
||||||||||||||||||||||||||||||||||||||.|||
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 86-245 3.3e-79 261.0 In-house 124-282 (315) alignment 
Range on Protein: 86-245
Range on HMM: 124-282/315.0
NAR-SCAQYWPD--ANSVQFGSYSVSTLSTSSDGDMTIRQLkVTRNSKTSHTVTQYQFHGWPKHGSDPQLGarSLMKLIRAVKSStNKMNEFSILVHCLS
. . .|.|||||  |.||.|||..|..||...|.|...|.| |||.|..|.||||.||..||..|.| |..  ||.|||..||.. |...|||.||||..
gdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
|.|||||.....|..|||....|||.|..||.|||.|...|||||||||.||...|.|.  | 
GvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 132-244 2.2e-56 186.0 In-house 171-280 (515) alignment 
Range on Protein: 132-244
Range on HMM: 171-280/515.0
SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNeFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAF
|.||||..|..||..|....  ..||.|||..||....... .....||..|.|||||........|.......||.|..|...|..|...|||.|.|||
srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

VYDVIREYLHTEN
.|....|.|.  |
iygavledllwrn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 83-246 5.9e-55 181.5 In-house 126-290 (297) alignment 
Range on Protein: 83-246
Range on HMM: 126-290/297.0
DHKNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILVHCL
|... ..||.||.|  ...||. || .||.|.   .  |.|.||... |. . | ||||  ||..  . .  |.||.|||  |. . .. .|  .|||||
dnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl

SGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.||| .. |.| .|...
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_PTPRD_pd Subfamily PTPRD 85-246 5.1e-46 152.5 In-house 128-287 (564) alignment 
Range on Protein: 85-246
Range on HMM: 128-287/564.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKV-TRNSKTSHTVTQYQFHGWPKHGSdPQLGaRSLMKLIRAVKSSTnKMNEFSILVHCLSG
|.   |..|||. .. ..|.. |.  ..    |..||..|. . .|. |..|.|..|  || ||  |. . .||..||| |.... . ..  |.||| .|
kgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv.pesa.tslLdlirkvraln.epdagPivVhCSaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
 ||||.|..   .. .| | . |||.|.|| ||..|   ||||| |.|....| |.|.  | |
VGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0050432 (Phosphotyrosine protein) phosphatases II 34-242 9.1e-45 148.7 In-house 22-301 (308) alignment 
Range on Protein: 34-242
Range on HMM: 22-301/308.0
TQSTTAVHDWSSILQQRNQADIIFLEFKEACDRVPhlLLSTKLQYYGISDHKNA----------------------------------------------
.  .. |.|.  .|.. ..  ... ||.| ..  |  ||...  .     .||                                               
sslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpn

----------------------------RSCAQYWPDA---NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgAR
                              ||||||.    .|...| ..| .||. ...|.|.|.|..|  ... |.|||......|| ||  |.  ..
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..pe

SLMKLIRAVKSSTnkmNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.|......|..|    ..  |.|||  | ||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | |.|... |||..
illdflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 86-244 5e-43 142.4 In-house 127-287 (305) alignment 
Range on Protein: 86-244
Range on HMM: 127-287/305.0
NARSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCL
.   | ||||.. .   .||..||   |...  | ..|.||..   ..| |.||.|||.  || ||  ||  | ||..||. |. . .| .. ..|||| 
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGv.pqf.atsllslikrvqkdqkkdkgvpllVhCs

SGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 | ||||||..    . .. . ..||.|. .| ||  ||. ||| ..| |..|.. |.... .
agvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0051299 (Phosphotyrosine protein) phosphatases II 51-240 6.6e-43 142.6 In-house 20-286 (288) alignment 
Range on Protein: 51-240
Range on HMM: 20-286/288.0
NQADIIFLEFKEACDRVPHLLLSTKLQYY--------------------------GISD-----------------------------------------
|.  ... ||.| ..  |.| ||. |                             . ||                                         
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

--------HKNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-----NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNk
         .. . ||||||. .|...| ..| .||. ...|.|.|.|.||.      ...|.|||......|| ||  .   ...|....|.|... . 
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd..spellldflrlvrkala.

MNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 ..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.. |||.| | |||... |||
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 85-242 1.8e-42 141.0 In-house 114-276 (284) alignment 
Range on Protein: 85-242
Range on HMM: 114-276/284.0
KNARSCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNK-MNEFSILVHC
..   ||||||. . ....| ..| .||.  ..|.|.| |..|..  .. |.|||......|| ||  |.  ...|....|.|... ..  ..  |.|||
ngrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHC

LSGAGRTGVFCTAMECIAQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
  | ||||.|.... .. |. ...    ||....|| ||  |...|||.| | |||... ||| .
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 43-240 2.8e-42 140.2 In-house 86-262 (263) alignment 
Range on Protein: 43-240
Range on HMM: 86-262/263.0
WSSILQQRNQADIIFLEFKEAcdrvphlllstklqyygisdhkNARSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLKVTRNS-KTSHTVTQY
|  ..... .  ... |..|                       . . |..|||.   .. .||..|| . .. ..  ....|.|..| .  .....||||
Wrmvweekvkiivmlteeeen......................gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

QFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMnEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|...||.|| .    ..|...|.||||.|...  .  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| |
qyknWpdhgvp..dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

YL
|.
yi
PTPc_SM00194 43-240 2.8e-42 140.2 In-house 86-262 (263) alignment 
Range on Protein: 43-240
Range on HMM: 86-262/263.0
WSSILQQRNQADIIFLEFKEAcdrvphlllstklqyygisdhkNARSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTIRQLKVTRNS-KTSHTVTQY
|  ..... .  ... |..|                       . . |..|||.   .. .||..|| . .. ..  ....|.|..| .  .....||||
Wrmvweekvkiivmlteeeen......................gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

QFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMnEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|...||.|| .    ..|...|.||||.|...  .  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| |
qyknWpdhgvp..dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

YL
|.
yi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 88-246 7.4e-42 138.5 In-house 129-286 (318) alignment 
Range on Protein: 88-246
Range on HMM: 129-286/318.0
RSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNKMNEFSILVHCLSGAGR
. ...|||. .| ..|.  |   .. . .|...|..||||. .. | .| ||..  || .|.  .    ||..|.| |..  .| ..  |.||| .| ||
akvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGr

TGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
||||..    . .|..   ||.||||| ||  |   ||||. | |.|||. |.|.. . |
tGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
0047943 (Phosphotyrosine protein) phosphatases II 48-240 9e-41 135.5 In-house 6-272 (273) alignment 
Range on Protein: 48-240
Range on HMM: 6-272/273.0
QQRNQADIIFLEFKEACDRVPhllLSTKLQYYGIS-----------------------------------------------------------------
..... .....||.. ..  |   | |.  .. .                                                                  
ekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

---------DHKNARSCAQYWPDAN---SVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTN
         . .. . ||||||. .   |...| ..| .||. ...|.|.|.|..|. ... |.|||.....||| ||  |     ||...|..|..  .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkale

KM-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.  ..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.  |||.| | |.|... |||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 86-244 1.5e-40 134.3 In-house 137-294 (298) alignment 
Range on Protein: 86-244
Range on HMM: 137-294/298.0
NARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNEFSILVHCLSGA
.   . .|||| .. ..|. .|| ||. . .|...|.|||.... .....| | .|  || .|   .  |.|...|.| |. |...  . ...|.| .| 
dktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen..atsvldllrkvrasqqqagnkpvivqCsaGv

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||.| |.     . .. .  .||.||.||.||..|.. |||||.|.|.|... |.|.. |
gRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0036941 (Phosphotyrosine protein) phosphatases II 84-245 2.7e-40 133.9 In-house 114-282 (297) alignment 
Range on Protein: 84-245
Range on HMM: 114-282/297.0
HKNARSCAQYWPDA--NSVQFGSYSVSTLSTSS--DGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNKM-NEFSIL
 ..   ||||||.   .|...| ..| .||...  ..|.|.|.|.||  ... |.|||.....||| ||  .   ..||...|..|..  ... ..  .|
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllpsggpvl

VHCLSGAGRTGVFCTAMECIAQIA---EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
|||  | ||.|.|..|  .. |.    .   |||...|| ||  |.. |||.| | |.|... |.| . ..
VHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
Y_phosphatase Protein-tyrosine phosphatase 83-236 5.5e-40 132.6 Pfam-A 77-233 (235) alignment 
Range on Protein: 83-236
Range on HMM: 77-233/235.0
DHKNARSCAQYWP--DANSVQFGSYSVSTL-STS-SDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTnKMNEFSI
. |. . ||||||  . .|...|...| .  ...  . ..|.|.|... . .   ...|.|.....||.||   .  ..||..|||.|..|. . .. ..
eekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpv

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
.|||  |.||||.|.... .. |. ....||..|.|| ||. |.. ||..|.|.|.|..|
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 83-236 5.5e-40 132.6 In-house 77-233 (235) alignment 
Range on Protein: 83-236
Range on HMM: 77-233/235.0
DHKNARSCAQYWP--DANSVQFGSYSVSTL-STS-SDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTnKMNEFSI
. |. . ||||||  . .|...|...| .  ...  . ..|.|.|... . .   ...|.|.....||.||   .  ..||..|||.|..|. . .. ..
eekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpv

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
.|||  |.||||.|.... .. |. ....||..|.|| ||. |.. ||..|.|.|.|..|
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRK_pd Subfamily PTPRK 87-238 1.1e-39 131.1 In-house 125-275 (314) alignment 
Range on Protein: 87-238
Range on HMM: 125-275/314.0
ARSCAQYWPDANSVqFGSYSVSTLSTSSDGDMTIRQLKVTR---NSKTSHTVTQYQFHGWPKHgSDPQlGARSLMKLIRAVKSSTNKmNEFSILVHCLSG
.  | .|||.  .| .|   |  ..|. . .. .| ..|..   . .  ..| |.|| |||.|   |.  |..|.||.| ||.|... ..  |.|||..|
rvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPv.satgllklvrrvkksqee.eaGrivvhCsaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|||||.|..    .  | . . ||.|..|| ||. .. .|.||| | |.|||| |
aGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 86-242 1.3e-39 130.9 In-house 89-244 (250) alignment 
Range on Protein: 86-242
Range on HMM: 89-244/250.0
NARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGA
. . . ||||  .. ..|.  || ||.   .|.|.|.||.....|... .| |..|  ||  |  |.  |.. ..|.. |..| .. ..  ..|.| .| 
sektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv.Pev.atavLellkkvqasqqqagnaPvivqCsaGv

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
||.| |..    . .. .   ||.|. .|.||.||.. |...| | ||| .| ..| .
grsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0040438 (Phosphotyrosine protein) phosphatases II 85-242 1.7e-39 131.3 In-house 123-278 (317) alignment 
Range on Protein: 85-242
Range on HMM: 123-278/317.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNkMNEFSILVHCLSG
.. . ||||||. .....| ..| .||.  ....|.|.|.|.  ....|.|||.....||| ||  |    ..| ....||... .  ..  .||||  |
lgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllldfleavreale.dpggpvlVHCsaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ||||.|..|  .. |. ..  ||....|| ||. |.. |||.| | |.||...||| .
vgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0039614 (Phosphotyrosine protein) phosphatases II 41-240 2e-39 131.3 In-house 19-289 (297) alignment 
Range on Protein: 41-240
Range on HMM: 19-289/297.0
HDWSSILQQRNQADIIFLEFKEACDRVPhlllSTKLQYYGISDHKNAR----------------------------------------------------
 |.   | ..|.  ...|||.| .. .|    ...  .   . .||                                                      
ldlllllekansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

--------------------------SCAQYWPDANSvQFGSYSVSTLSTSSDGDMTIRQLKVTRnSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIR
                           ||||||.  . ..| ..| .|..  ....|.|.|.||. .. |.|||..|..||| ||  |   ...|.....
edFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvpp..slelllefle

AVKSSTNKM-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|..  ..  ..  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | |.||...|.|
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0043336 (Phosphotyrosine protein) phosphatases II 85-240 9.4e-38 125.7 In-house 125-277 (278) alignment 
Range on Protein: 85-240
Range on HMM: 125-277/278.0
KNARSCAQYWPdANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNkMNEFSILVHCLSG
..   ||||||  .|...| ..| .|.. ...|.|.|.|.||.  .. |.|||.|...||| ||  .     .|.....||..  .  ..  .||||  |
lgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavreale.dsngpvlVHCsaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | |.|....|||
vgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 85-239 1e-37 124.8 In-house 127-278 (288) alignment 
Range on Protein: 85-239
Range on HMM: 127-278/288.0
KNARSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVTrNSKTSHTVTQYQFHGWPKHGsDPQlGARSLMKLIRAVKSsTNKMNEFSILVHCLSG
.. . | .|||||.  ...||  |  ...   .|.. |.| .   .||  ..||||. .|| ||  |.  .. |..|.| ||  .|. .   |.|||  |
ggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhg.vPe.skapllellrqvkv.anqadtgpiivhCsaG

AGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
 ||||.| ..   | .. | | .|.. ||. ||  |...|||.. | |.|.|. . 
vGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPRA_pd Subfamily PTPRA 85-241 1.2e-37 124.5 In-house 138-297 (330) alignment 
Range on Protein: 85-241
Range on HMM: 138-297/330.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVT-----RNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEfSILVH
..   |||||||  .| .|   |.   .    |.|.|.. |.     .. |.|  |.|. |..||. |  |   .. ..||...||.  ... . .| ||
rkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv.Pf.epiGmlkllkkvkklnqqsag.pivvh

CLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY-LH
| .|.|||| |..    ....     ||.|..|| ||. | | |||.| | |.| |..|| |.
csaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
0045450 (Phosphotyrosine protein) phosphatases II 50-240 5.6e-37 123.5 In-house 23-304 (307) alignment 
Range on Protein: 50-240
Range on HMM: 23-304/307.0
RNQADIIFLEFKEACDRVPHLLLSTKLQYYGISDHK----------------------------------------------------------------
..   ... ||.. ..  ..|| ...  ..  . .|                                                                
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

----------------------NARSCAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKL
                      . . ||||||| ... ..| . | .||.. ....|.|.|.||.   .. |.|||.....||| ||  |     .| ..
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldf

IRAVKSSTNKM-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|..|..  ..  ..  .||||  | ||||.|..|  .. |. ..     ||....|| ||. |.. ||..| | |.|....|.|
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 88-244 9e-37 121.7 In-house 134-289 (293) alignment 
Range on Protein: 88-244
Range on HMM: 134-289/293.0
RSCAQYWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRnSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSST-NKMNEFSILVHCLSGAG
  | .|||.  ..|..|. .|. .....  | .||.||... .|....|.||.|  || ||  |.  ...|....|.|.... .....  |.||| .| |
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgv.Pe.ktktlldfvrtvreaiektaskrPivvhCsaGvG

RTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
|||.| .  . . .| | | |||| .|  || .|...||||..| |..... ..|....
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 85-242 1.5e-36 120.8 In-house 128-285 (290) alignment 
Range on Protein: 85-242
Range on HMM: 128-285/290.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAVKsSTNKMNEFSILVHCLS
..   | |||||... ..| .|.  |. ..  ....|.|.|. ...  ....|||||.  |...|. ..  . .|. . . .|    |  . ||.|||  
egkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp.qtillvieemyk.tqrkrgntsivvHCSd

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
. ||..|||.|.  | .      .|.|| .| .|  ... |||...| ...... .||..
tvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0040439 (Phosphotyrosine protein) phosphatases II 85-240 2.2e-36 121.1 In-house 91-246 (249) alignment 
Range on Protein: 85-240
Range on HMM: 91-246/249.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKM-NEFSILVHCLS
..   ||||||. .|...| ..| .||. . .|.|.|.|..|.   ..|.||...|...|| ||  |     .|...|.||..  ..  ..  .||||  
lgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvpps..fedlldfieavrkaleelpkggpvlVHCsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
| ||||.|..|  .. |. .   ||....|| ||  |.. ||..| | |.|....|.|
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 85-240 2.6e-36 120.7 In-house 89-243 (245) alignment 
Range on Protein: 85-240
Range on HMM: 89-243/245.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSStnkMNEFSILVHCLS
..   ||||||. .|...| ..| .||. ...|.|.|.|.||.  .. |..|..|....|| ||  .      ......| . ..    ..  .||||  
lgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsa

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
| ||||.|..|  .. |. .   |.....|| ||  |.. |||.. | |.|....|.|
GvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 86-241 2.4e-35 117.7 In-house 102-273 (278) alignment 
Range on Protein: 86-241
Range on HMM: 102-273/278.0
NARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-----NSKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVKSSTN---KM------
.   ||||||. .|...| ..| .||..  .|.|.| |.||      .. .|..||......|| ||. ..   .|. .|.. ...  .   ..      
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---NEFSILVHCLSGAGRTGVFCTAMECIAQIaeGDSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYLH
   ..  .||||  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | |.|....|.|.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 89-244 2.9e-35 116.9 In-house 132-287 (319) alignment 
Range on Protein: 89-244
Range on HMM: 132-287/319.0
SCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTS--HTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGR
 . .|||..| ...| . |  ..     |. ||.||. ..|      .|...|.  || |.  |.  |.||..|.. .. |..| ..  | |||  |.||
klkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv.Pek.atslldllkrirksrektqsgPivvhCsaGvGR

TGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
|| |..    . .. |   .|.|.||. ||. |   ||..| | |.|....|.... .
tGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 85-244 5.4e-35 115.8 In-house 123-282 (287) alignment 
Range on Protein: 85-244
Range on HMM: 123-282/287.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAVKSStNKMNEFSILVHCLS
.. . | ||||. .|| .| |... |.     ....|.|.|....|.   ..|.|||.  |...|  ..  . .|. . . .|.   |  . ||.|||  
ndeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieemyktq.rkrgntsivvhCsd

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
. ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| |..|.. |||.. .
tvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Ptp69D_pd Subfamily Ptp69D 84-245 6.6e-35 115.7 In-house 127-291 (307) alignment 
Range on Protein: 84-245
Range on HMM: 127-291/307.0
HKNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSK------TSHTVTQYQFHGWPkHGSDPQLgARSLMKLIRAVKSsTNKMNEFSIL
 || . ||.|||. . ||.|.  | . |... .| .||.|.|... .       |. |.||.. ||.     |.  ||.|.|||. |..  .|.|.  |.
eknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPev.argllklieqvre.lyklnrsPiv

VHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
|||  |.||.|.| .    . |. . |.||||.||| || .|  .||  | | |.|  . .| .  . 
vhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt
0037934 (Phosphotyrosine protein) phosphatases II 86-240 2.6e-34 114.2 In-house 86-242 (243) alignment 
Range on Protein: 86-240
Range on HMM: 86-242/243.0
NARSCAQYWPdaNSVQFGSYSVSTLSTSSDGDMTIRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSST----NKMNEFSILV
..  ||||||  ..|..| ..| .||... .|.|.| |....   .. ...|..|....|| ||  .      .... .|.. ...    .  ..  .||
grekcaqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV

HCLSGAGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYL
||  | ||||....|  .. ..    .||....|| ||. |..  |||.. | |.|....|.|
HCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 88-242 1.4e-33 111.0 In-house 123-279 (290) alignment 
Range on Protein: 88-242
Range on HMM: 123-279/290.0
RSCAQYWPDA--NSVQFGSYSVSTLSTSS-DGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNkMNEFSILVHCLSGA
  |..|||.   ....||...|.. .    | |..||.|||... |.|..|.|.... || ||  |. .| ||..||..|..  .  ..  ..||| .| 
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgv.Ps.saksllelielvrelqe.sedaPlvvhCsaGv

GRTGVFCTA---MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
||||. ..     | . .    ...|.|. |  || .|   |||.| | .||  . |....
GrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPRG_pd Subfamily PTPRG 84-247 2.6e-33 110.0 In-house 127-294 (563) alignment 
Range on Protein: 84-247
Range on HMM: 127-294/563.0
HKNARSCAQYWPDANSVQFGSYSVS-----TLSTSSDGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPKHGSdPQlgaRSLMKLIRAVKSSTNKMNE-FS
....| | .|||  .|...|. .|      .|....   ..|..||. ....  | ..|.||..  || ||. |.    ||..|| ..|||. ...|   
ergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv.Pe...hslpvLifvkkssaankaeaGP

ILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
|.||| .|.||||...     . || . ..|..|...| .|| |   |||||.| |..|.. | . ... | 
ivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel
subfamily_PTPN6_pd Subfamily PTPN6 85-244 7.2e-33 108.9 In-house 135-301 (306) alignment 
Range on Protein: 85-244
Range on HMM: 135-301/306.0
KNARSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVT--RNSKTSHTVTQYQFHGWPKHGSDPQLGAR-SLMKLIRAVKSSTNKMNEFSILVHC
..   ||.||||...  ..|..||...| .|  | ..|.|.|.  ...|....| ||.|. || ||   . ||  .... ... ......... .|.|||
rgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC

LSGAGRTGVFCTAMECIAQI---AEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 .| |||| |      . .|        .|| ..||..|. | ..||||. | ||| .|..|..|..
saGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 88-238 1.2e-32 107.9 In-house 115-264 (283) alignment 
Range on Protein: 88-238
Range on HMM: 115-264/283.0
RSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLiRAVKSSTNKMNEFSILVHCLSGAG
  |.||||   |...| . |.     .   ..|..| .  |  .|..  .. ||. .| . | .. .   ||.|.   |.|  .. ..  |.||| .| |
ikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaii..nslvkf.nkvislqteskkgPivvhCstgiG

RTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
||.||..|.  . ..     ||.|..|||.| .||  ||| . | .|.... |
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 86-244 1.3e-32 108.2 In-house 128-292 (325) alignment 
Range on Protein: 86-244
Range on HMM: 128-292/325.0
NARSCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT-SHTVTQYQFHGWPKHGSDPQLG-ARSLMKLIRAVKSS--TNKMNEFSILVH
.  .||.|||.   .|..||.  |.  .     |   |.|.| . .|  . .| |.|. .|.  | . .     |...|. ||.    .|      ||||
gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvh

CLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
| .| |||||| .    .|.. |  .||||. || ||.|| . |.| ..| ..|. . |.. . |
csaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 89-242 1.2e-31 104.8 In-house 125-278 (281) alignment 
Range on Protein: 89-242
Range on HMM: 125-278/281.0
SCAQYWPDAN-SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRT
 | .|||| | ....| . |.......   .  |..|..|.|  . .|.| ..  || ||  |.  .. |..  ..|.. |.| .. ....|| .| |||
kChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGv.Pa.ttkellefrkevlkltekktkaplvihCsaGvGrt

GVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
|.. .    . ... |  ..|. ..|. || .|. .|||   |.||| .. ..|. 
GtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 88-241 2.8e-31 104.0 In-house 138-293 (319) alignment 
Range on Protein: 88-241
Range on HMM: 138-293/319.0
RSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNKMNE-FSILVHCLSGA
  |.||||    .. . . |.  |     . ..|.......   |    .||. | |||..|  |. ..  ||.|.. |.  |.|.|.  .|.||| .|.
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGv.pdyps.dlmrlvkkvrhltskenhranivvhcsaGv

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
|||||. .    . .. | . ||....|. || .| ..||   .| |.|  . | .| 
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 88-241 5.8e-31 103.0 In-house 102-257 (284) alignment 
Range on Protein: 88-241
Range on HMM: 102-257/284.0
RSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNKMNE-FSILVHCLSGA
  |.||||    .. . . |.  | .   ....|.......   |   ...|. | |||..|  |. ..  ||.|.. |.  |.|.|.  .|.||| .|.
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgv.pdyps.dlmrlvkkvrhltskenhranivvhcsagv

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
|||||. .    . .. | . ||....|. || .| ..||   .| |.|  . | .| 
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 85-239 7.3e-31 102.3 In-house 129-278 (315) alignment 
Range on Protein: 85-239
Range on HMM: 129-278/315.0
KNARSCAQYWPDAnSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSdpQLGARSLMKLIRAVKSStNKMNEFSILVHCLSGA
.. | . .||||   | .| ..|.  |     ..|.| | |. ...  ..| |...  ||. |      . .||.||| ||   .. .  .|.||| .| 
gekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqh.htnsvgaivvhcsaGv

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
|||| |.|    . |.   . .|... .. .|. |.. ||. |.| |.||.. | 
GrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_CG7180_pd Subfamily CG7180 86-241 7.7e-31 101.8 In-house 122-291 (296) alignment 
Range on Protein: 86-241
Range on HMM: 122-291/296.0
NARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-----------SKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAVKSSTNKM---
 |. . .|||     |.|   | .... .  ...||..|.|..           .    .|...|.  |. . . |   . .|..|.| |..  .|.   
fakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPls.tnalielrrrvrlwrekvded

-NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
 .|  ..|..  ||.|.||....  .. .. . . ||.|. || || .| | |.. ||| ..|||. |.. 
peegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN9_pd Subfamily PTPN9 87-240 8.7e-31 102.0 In-house 124-290 (297) alignment 
Range on Protein: 87-240
Range on HMM: 124-290/297.0
ARSCAQYWP--DANSVQFGSYSVSTLSTSSDGDMTIRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKS------------STNKM
 . |.||||  . .| .||..|||.... .  | ..|.|...  . . | .|| .|| .|| .|  |.  | ||......|..            .. ..
rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGv.Ps.saaslldvlekvrekqalavkelgdewkghp

NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
..  |.||| .| |||| |.|   |.... | . ||...||| ||. |   .||.| |.| |  . || 
sgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 84-243 1.3e-30 101.3 In-house 100-267 (270) alignment 
Range on Protein: 84-243
Range on HMM: 100-267/270.0
HKNARSCAQYWPDANSV----QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSDPQLG----ARSLMKLIRAVKSSTNKMNEF-
 |. . |..|||  .      ..|  .| .||.. .    ...|........ . .. .... || ||  .. .    ...|.|..|||. |......  
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

SILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 .||||  | ||||.. .   ..  . |  .||. . .. || |||..||. |.|.|.| ...|| .. 
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 84-242 3.6e-30 100.0 In-house 109-270 (274) alignment 
Range on Protein: 84-242
Range on HMM: 109-270/274.0
HKNARSCAQYWPDANSV----QFGSYSVSTLSTSSDGDMTIRQLKVTRNSKtSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNEF--SIL
 .| . ||.|.|||...    ..|  .. . .. .  | ..|.| .   .. ...|. | .  || | |  .  |..|..|.. |..| .. |.   ...
eaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvv

VHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
||| .| ||||.| ..  .. |. |   ||....|  || ||   |||.| | ... .. .||. 
vhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
PTPc_DSPc_SM00012 134-237 1.9e-28 94.1 In-house 1-104 (105) alignment 
Range on Protein: 134-237
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNKMN-EFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||   .    |...|.||||...|| . . ...|||  |.||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

VYDVIR
.|... 
lyrall
subfamily_PTPN3_pd Subfamily PTPN3 89-237 6.6e-28 92.4 In-house 125-272 (280) alignment 
Range on Protein: 89-237
Range on HMM: 125-272/280.0
SCAQYWPDA-NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKMNEfSILVHCLSGAGR
 | ||||.  .....|..||   .....  . .|.| ..... | .....| |.  || ||  |.  . ....... |..  . ..|  ..||| .| ||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgv.Pd.dsadflefvervrklrsgkee.PvvvhCsaGigr

TGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
|||. .   ..| | . ..| . . |. .|  |. .|||.. | || . | 
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0051429 (Phosphotyrosine protein) phosphatases II 86-242 3.6e-27 91.1 In-house 59-227 (272) alignment 
Range on Protein: 86-242
Range on HMM: 59-227/272.0
NARSCAQYWP------------DANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAvksstnkm
..  | .|||            .| .. .| ..| .||..   |...| | .|.    .....|.......|| ||  ..   ..|..|...        
grlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld........

nEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVD--------IFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 .  .|||| .| .|||... .  ..... . . ||        ....|. ||| |...||||| |.|.|....|.| .
.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_PTPN14_pd Subfamily PTPN14 88-241 1.6e-26 88.0 In-house 133-297 (300) alignment 
Range on Protein: 88-241
Range on HMM: 133-297/300.0
RSCAQYWPDA----NSVQFGSYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQL-GARSLMKLIRAVKSSTNKMNE-----FSI
  . .|.|.     ..|.|| . |.|  ... . .. ..||.    ||   ||   |.  ||.||  . . |  | .. ...|.  ||...|       .
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
||||. |.|||||  ..   || .  ....|| .....||  || .|||   | |||.|. .||.
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN23_pd Subfamily PTPN23 85-242 3e-26 86.9 In-house 120-282 (288) alignment 
Range on Protein: 85-242
Range on HMM: 120-282/288.0
KNARSCAQYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN-SKTSHTVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKS---STNKMNEFSILV
..  ....||| .  ..|.|| .||.  |. . . .  |.||.. . ... ..|.  |.. ||..|  |.    .|.... .|.|   ....  .  ..|
lgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGv.Pa.sPetllqfldevesayeavqrksktPlvv

HCLSGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
||..| ||||||.  .  .... .|. . || | |. ||..|   ||..|.. |.|... |. . 
hCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 87-244 4.2e-26 86.4 In-house 124-297 (301) alignment 
Range on Protein: 87-244
Range on HMM: 124-297/301.0
ARSCAQYWPDANSV--QFGSYSVSTLSTSSDGDMTIRQLKVT----------------RNSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSST
  .| ||||...    .||  .|   ..    |..||||.|.                ...|.|..|.|.|   ||..|  ..   |  .. |  |   .
kskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre..prtvLqviddvihrq

NKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.|..   ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | ..|||| .||. ..
qkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_PTPN13_pd Subfamily PTPN13 89-241 3.5e-25 83.8 In-house 118-270 (273) alignment 
Range on Protein: 89-241
Range on HMM: 118-270/273.0
SCAQYWPDANSVQFGS---YSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmNEFSILVHCLSGA
 | .|||. .. .      . |. | .    ....|.|.|.  .|. |. |.. .|  || ||   .  | .|..... |..  .  ..  |.||| .| 
kchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPivvhcsaGi

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
||.|.. |    .  |.   ..|. ..|. ||  |   |||.. | ||| .| | |.
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 85-237 8.5e-24 79.1 In-house 82-236 (237) alignment 
Range on Protein: 85-237
Range on HMM: 82-236/237.0
KNARSCAQYWPDANS-VQFGSYSVSTLSTSSDGDMTIRQLKVTRNS--KTSHTVTQYQFHGWPKHGSdPQLGARSLMKLIRAVKSSTNKMNEFSILVHCL
.|   | .|||...    .| ..||        | |.| | ....   |    . ||||  ||..|  ||  |  |    . .. |    .    ..|| 
gnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgv.pqqtaallrfrkniinrsphvsesgpwiihcs

SGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
.| ||||.|      . |  |   |||.. |. .  ||   .||...| |....| 
agvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPRN_pd Subfamily PTPRN 85-238 3.4e-23 76.8 In-house 137-290 (297) alignment 
Range on Protein: 85-238
Range on HMM: 137-290/297.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSD-GDMTIRQ--LKVTRNSKTsHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKmNEFSILVHCL
.. . |..||||  |  .. | |  .|      |  .|   ||  ..|.|  ||||. |  ||..|  ..  |.||... | |  |       .|.||| 
egvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPas..aksllefrrkvnksyrG.rscpivvhcs

SGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
.|||||||..     ..... |   .||  |.. || .| ..|.|.... |.. .. |
dGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 84-131 1.2e-22 74.7 In-house 406-453 (515) alignment 
Range on Protein: 84-131
Range on HMM: 406-453/515.0
HKNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT
 .| .|||||||||||||||||||||||||||||||||||.|||||| 
sqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskr
0041856 (Phosphotyrosine protein) phosphatases II 85-245 1.3e-22 75.7 In-house 63-176 (182) alignment 
Range on Protein: 85-245
Range on HMM: 63-176/182.0
KNARsCAQYWPdansvqfgsysvstlstssdgdmtirqlkvtrnSKTSHTVTQYQFHGWPKHGSDPqlgARSLMKLIRAVKSstnkmNEFSILVHCLSGA
 |.. . .|||                                 ..  ....||....|| ||  .    ..| ..|..|..     ..  .||||  | 
vnlt.eelywp.................................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGv

GRTGVFCTAMECIAQiaegdSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
||||... |  .. .     .|.....|| .|  |.. |.|.. | |......|.|.  ..
gRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0036282 (Phosphotyrosine protein) phosphatases II 84-234 9.8e-22 72.9 In-house 48-164 (174) alignment 
Range on Protein: 84-234
Range on HMM: 48-164/174.0
HKNARSCAQYWPDansvqfgsysvstlstssdgdmtirqlkvtRNSKTSHTVTQYQFHGWPKHGSDPQLGarsLMKLIRAVKSSTNKMNEFSILVHCLSG
...   | .|||.                              . .  .... ||.. .|| ||  .      | .....|..  .. ..  .||||  |
elglykcinywpe..............................lredlerlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaG

AGRTGVFCTAMECIAQIAeGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
 ||||... |. .. ..   . ||....|. ||  |.. |||.. | |.|.
vgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 83-235 2.2e-21 71.1 In-house 88-235 (239) alignment 
Range on Protein: 83-235
Range on HMM: 88-235/239.0
DHKnaRSCAQYWPDANSvQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLGArSLMKLIRAV-KSSTNKMNefSILVHC
 ||  . | |||||. | ..    |.   |    |  || . ...  .|    | ||.|  || .|  ||  . ... | | . | |         ..||
ghk..kkchqywpdsts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgv.pqyat.avlglrrkitkdslpgar..pwvihc

LSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .| |||| |      . |  .  .||||. || .| || ..||| |.| |..  
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 83-234 2.5e-21 71.0 In-house 89-235 (239) alignment 
Range on Protein: 83-234
Range on HMM: 89-235/239.0
DHKnaRSCAQYWPDANSvQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSH-TVTQYQFHGWPKHGSdPQLGArSLMKLIRAV-KSSTNKMNefSILVHC
 ||  . | |||||. | ..    |.   |    |  || . ...  .|    | ||.|  || .|  ||  . ... | | . | |         ..||
ghk..kkchqywpdsts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgv.pqyat.avlglrrkitkdslpgar..pwvihc

LSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
 .| |||| |      . |  .  .||||. || .| || ..||| |.| |.. 
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 87-236 3.4e-21 70.1 In-house 272-434 (440) alignment 
Range on Protein: 87-236
Range on HMM: 272-434/440.0
ARSCAQYWP-DANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKH----GSDPQLG----ARSLMKLIRA--VKSSTNKM---N
 ..|. ||| .. || || ..|    .     . .| |..  . .  | . |..   ||      | . |         ||  .|   .. ||..    .
dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk.eevheirqfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgd

EFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
   ||||||||   .||||| |.|. |. .  ..|.|| ...||  | .|| |  .| ..| ..
gppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 88-243 6.5e-21 69.3 In-house 119-280 (287) alignment 
Range on Protein: 88-243
Range on HMM: 119-280/287.0
R-SCAQYWPDAN-SVQFGSYSVSTLST-SSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQ-LG-ARSLMKLIRAVKSSTNKMNEFSILVHCL
|  | .|||. .  .. | |||  |.    . . ..| |..     . .. | |...  ||...  |  .| .|  ..  . .. . .  .   ..||. 
rlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhdd

SGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 |.||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|. .  | .|.
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 84-240 1.5e-20 68.1 In-house 122-279 (439) alignment 
Range on Protein: 84-240
Range on HMM: 122-279/439.0
HKNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNS---KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNKMNEFSILVHC
  |     .|||  . | .|  .| .       . .|| .||  .    .  .|| |...  ||..    |  |  .....||..|. .| .   ..|||
ltnlvesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeeygpvvvhc

LSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 .| ||||   .   .. |.   . |||   ||.|| .| |.||.  .| |.|. . | .
sagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_PTPN1_pd Subfamily PTPN1 85-238 4.5e-20 66.5 In-house 108-269 (290) alignment 
Range on Protein: 85-238
Range on HMM: 108-269/290.0
KNARSCAQYWPDA---NSVQFG--SYSVSTLSTSSDGDMTIRQLKVTR-NSKTSHTVTQYQFHGWPKHGSdPQLGARSLMKLIRAVKSSTNKMNEFSILV
|.   ||||||     .....   ...|  .|. .    |.|.|...  ... ....... .  ||  |  |.  |  |  | .  .| . . .    ..
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgv.pespaaflkflfkvresGslssdvGpavi

HCLSGAGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|| .| ||.| || .  |...| . |    ||| ...  ||  |. ..|| .   | |  | |
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 89-245 2.4e-19 64.1 In-house 135-288 (290) alignment 
Range on Protein: 89-245
Range on HMM: 135-288/290.0
SCAQYWPDAN--SVQFGSYSV-STLSTSSDGDMTIRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdpqlgARSLMKLIRAVKSsTNKMNEfSILVHCLSGA
 |.||.|. .   . ||...|  ..... | ..  . | |  ..|  .| .  ..   || .       | | . |.| ...   |..   . ||| .| 
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtlri.lrkasG.pvvvhcsaGi

GRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
|||| | .   ..  . .| ..|. ..|. ||  |.. || . .|  . ... ..    .|
GrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
0046846 (Phosphotyrosine protein) phosphatases II 84-240 2.9e-19 64.9 In-house 59-173 (176) alignment 
Range on Protein: 84-240
Range on HMM: 59-173/176.0
HKNARSCAQYWPDANSVQFgsysvstlstssdgdmtirqlkvtrnsktshtvtQYQFHGWPKHGSDPQlgaRSLMKLIRAVKSSTNKMneFSILVHCLSG
...  .|..|||.  ....                                  ||....|| ||  .    . |..|......  ..     .||||  |
elgrlkcpnywpeleklgi..................................qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaG

AGRTGVFCTAMeciaQIAEGDSVDIFQTVKILRADRM-QFVQTEEEYAFVYDVIREYL
 ||||... |      .  .  ........ .|. |. . |||.| | |.|......|
igRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 85-237 5.1e-19 63.5 In-house 108-256 (290) alignment 
Range on Protein: 85-237
Range on HMM: 108-256/290.0
KNARSCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmnefSILVHCLS
..  .||.| |..    ..|.  .|.  |   . |. .|.| |. . .  .||| ....|| |    ..   ..|..||. || |.       ..|||  
tslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqed..tktllsliqkvkaskt.....pvivHcvd

GAGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
|  |  .. .       ||   .|| . . .| ||  | . .....|.|||  .| 
GiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
0043147 (Phosphotyrosine protein) phosphatases II 125-234 1.6e-17 59.2 In-house 55-155 (172) alignment 
Range on Protein: 125-234
Range on HMM: 55-155/172.0
VTRNSKTSHTVTQYQFHGWPKHGSDpqlGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQ
..  .. .... ||....|| ||      .. |..... ...  .. ..  .||||  | ||||... |  ..       .......|. .|. |.. ||
lydpellerlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TEEEYAFVYD
... | |.|.
npsqyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 89-236 1.9e-17 58.7 In-house 48-149 (151) alignment 
Range on Protein: 89-236
Range on HMM: 48-149/151.0
SCAQYWPDANsvqfgsysvstlstssdgdmtirqlkvtrnsktsHTVTQYQFHGWPKHGsdPQLGARSLMKLIRAVKSstnkMNEFSILVHCLSGAGRTG
 |..|.|...                                  ..|.......|| .|   .|   ......... .    ...  .|||| .| ||||
ycpeylpelg..................................ievlhipildwpdpg..lplsfdavleflellld....kkngpvlvHCsaGkgRTG

VFCTAMECIAQiaegdsVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
... .. .. .      |....... .|. |. .||..... |.. ..
tlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 90-248 5.9e-17 56.6 In-house 124-288 (307) alignment 
Range on Protein: 90-248
Range on HMM: 124-288/307.0
CAQYWP-----------DANSVQFGSYSVSTLSTSsDGDMTIRQLKVTRNSKtSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNkmnefSILV
| ||||            .|..      . .|.   .  . . .|||   .| | |....|.. || .|  ||.   . . |. ||.  ||      ..|
ceqywpleegqklvfgeapntisvanlgakklapd.edlinvttlkvdwaqk.srtiqhlqwenwpdrgv.pqinl.tainlleavrydtn.....pvvv

HCLSGAGRTGVFCTAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY---LHTENYEQL
|| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| ... |. ||   |. | ||.|
hcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
0048076 (Phosphotyrosine protein) phosphatases II 128-239 9.9e-17 56.4 In-house 40-142 (145) alignment 
Range on Protein: 128-239
Range on HMM: 40-142/145.0
NSKTSHTVTQYQFHGWPKHGSDPQ-LGARSLMKLIRAVKSStnkmnEFSILVHCLSGAGRTGVFCTAMECIAqiaegDSVDIFQTVKILRADRMQFVQTE
 .  .....||.. .|| ||  .     ......|... ..     .  .||||  | ||||... |. ..       .|....... .|. |...|...
lellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnp

EEYAFVYDVIREY
. . |.|....|.
gqlrflyefelel
0049260 (Phosphotyrosine protein) phosphatases II 87-234 3.5e-16 54.7 In-house 48-144 (152) alignment 
Range on Protein: 87-234
Range on HMM: 48-144/152.0
ARSCAQYWpdansvqfgsysvstlstssdgdmtirqlkvtrnsktshtvtQYQFHGWPKHGSDPQLGARSLMKLIRAVKsstNKMNEFSILVHCLSGAGR
   |.||.                                          ||... || ||  .       . |.       .. ..  .||||  | ||
klkceqyi..........................................qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgR

TGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
||... |  ..        |.....|. .|. |.. |.... . |.|.
tgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 122-234 8.3e-16 53.5 In-house 48-139 (144) alignment 
Range on Protein: 122-234
Range on HMM: 48-139/144.0
QlkvtrnsktshtVTQYQFHGWPKHGSDPQ-LGARSLMKLIRAVKSstnkmNEFSILVHCLSGAGRTGVFCTAMECIaqiAEGdsVDIFQTVKILRADRM
.            ..||.. .|| ||  .     ......|... .     ..  .||||  | ||||....|  ..    .|  ........ .|. |.
e............giqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrp

QFVQTEEEYAFVYD
. |.... . |...
gavpnpgqlrfLle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 89-245 3.8e-15 50.3 In-house 137-293 (305) alignment 
Range on Protein: 89-245
Range on HMM: 137-293/305.0
SCAQYWPDANSVQF---GSYSVSTLST----SSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQlGARSlMKLIRAVKSStnkmnEFSILVHCL
 |||||| |.  .    .   |  .|       | .. |  |..| . . . .| . |.  ||  |  |     | ..|. |.. |     .  |.||| 
kcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc.klts.lellsairgs.....kvpivvhcs

SGAGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHtENY
.| ||||   .    . .|||  ..  . . || || .|   .|.. .| |.. |. .|.  |.|
agigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky
0044763 (Phosphotyrosine protein) phosphatases II 85-241 8.8e-15 50.3 In-house 61-172 (178) alignment 
Range on Protein: 85-241
Range on HMM: 61-172/178.0
KNARSCAQYWPDANSvqfgsysvstlstssdgdmtirqlkvtrnsktshtvTQYQFHGWPKHGSDP-QLGARSLMKLIRAVKSSTNkmneFSILVHCLSG
 .  .| .|||. ..                                     ||.. ..| ||  .     . ....|... .. .      .||||  |
lgflkcdpywpeeag....................................iqylhipipDhgvpdllehflefvefieealdekg....gpvlVHCsaG

AGRTGVFCTAMECIAQiaegdSVDIFQTVKILRADRMqFVQTEEEYAFVYDVIREYLH
 ||.|... |  .. .     ...... .. .|. |. .|.... . ..|.. ...| 
vgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 92-240 8.8e-15 49.4 In-house 113-259 (267) alignment 
Range on Protein: 92-240
Range on HMM: 113-259/267.0
QYWPDA--NSVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDpQLGARSLMKLIrAvKSSTnKMNEFSILVHCLSGAGRTGV
..||    .. ..   .|       . |  |  |..  . ...| || | .. |     . .   . |. .. | |    .  .  ..|.|  | ||.| 
lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnn.kpylkplfgil.a.knql.engnrPlvvacsdGvGrsGt

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
| ..   . .. . . .|||. .. .|  |. .|.| |.| ...... || 
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
0049772 (Phosphotyrosine protein) phosphatases II 129-241 1.9e-14 49.6 In-house 174-281 (314) alignment 
Range on Protein: 129-241
Range on HMM: 174-281/314.0
SKTSHTVTQYQFHGWPKHGSDPQLGARSLMKLIRAVksstnkMNEFSILVHCLSGAGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRM-----QFV
.. .... .|  . .| .. ..    ......|...       ..  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |.
elferlgikylripvpDgsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfi

QTEEEYAFVYDVIREYLH
.. |.| |......||| 
eqleqyefilealleylk
subfamily_CG42327_pd Subfamily CG42327 162-239 2.4e-14 47.8 In-house 235-314 (319) alignment 
Range on Protein: 162-239
Range on HMM: 235-314/319.0
RAVKS-STNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
  . | | .. .   . |||  |.||||.  ..   | .. |   |||| |.|  .| || . |.| | |.|.| |. ||
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 88-243 3.3e-14 47.5 In-house 115-273 (285) alignment 
Range on Protein: 88-243
Range on HMM: 115-273/285.0
RSCAQYWPDA--NSVQFGSYSVSTLSTSSDG-DMTI-RQLKVTRNSKTS-H--TVTQYQFHGWPKHGSdPQlGARSLMKLIRAVKSSTNKmnEFSILVHC
  || |.|.   . |.|| | ..      .    ||   | |.    .|     . . |   || . . |.  || ...| . ||    |  |  | |||
ekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla.pe.darpmielykwvkkvnpk..ekpicvhc

LSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 .| |||  |     .  .| |   ..... |. .|| |.| ||.  .. |.| |. ||.  |
sagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 102-247 4.2e-14 47.3 In-house 138-278 (288) alignment 
Range on Protein: 102-247
Range on HMM: 138-278/288.0
FGSYSVSTLSTSSDGDMT--IRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLgaRSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQ
.| .   .    .| | .  .  |..... ...  | .  .. |...|   .    | ..|.  .|| ..      |.||.  |.|||| .   .  . .
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPeny..lsplrllevlkslqk.....PivvhssaGvGrtgtlililiales

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
.   | . | . .. ||..|.. .|||  | .|. .. |.|    |..
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 84-238 5.2e-14 46.7 In-house 126-284 (301) alignment 
Range on Protein: 84-238
Range on HMM: 126-284/301.0
HKNARSCAQYWPD--ANSVQFGSYSVSTLSTSS--DGDMTIRQLKVTRNSK--TSHTVTQYQFHGWPKHGSdPQLGArSLMKLIRAVKSSTNkmnefSIL
 |. . |..| |   ..... | ... . .. .  . ... |.|.|.  ..  ...||| ||.. |...|  |.  |  |..|.  || | .      |.
ekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgv.Pksha.elfdlmelvkksek.....Piv

VHCLSGAGRTGVFCtAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAF-----VYDVIRE
||| .| ||.  |  . |..|.  | |  ... ...| || .| . |||..   .     || .|.|
vhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 178-240 5.9e-14 46.2 In-house 2-64 (69) alignment 
Range on Protein: 178-240
Range on HMM: 2-64/69.0
VHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| |..| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 177-240 7.6e-14 45.9 In-house 2-65 (69) alignment 
Range on Protein: 177-240
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || |..| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 83-235 1.1e-13 45.8 In-house 39-199 (199) alignment 
Range on Protein: 83-235
Range on HMM: 39-199/199.0
DHKNAR-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT---SHTVTQYQFHGWPKHgSDPQLG-ARSLMKLIRAVKSSTNKMNEFS
| ||     . ||| ..|   ..|| ||.| . ..  |.||  | .| |. .   .  ...|||  | .. . |..     ..   | |    .. ..  
dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkek.ttpnvalfvgfvvasrevskkyeqekdap

ILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
vivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 83-235 1.1e-13 45.8 In-house 38-198 (198) alignment 
Range on Protein: 83-235
Range on HMM: 38-198/198.0
DHKNAR-SCAQYWPDANS--VQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKT---SHTVTQYQFHGWPKHgSDPQLG-ARSLMKLIRAVKSSTNKMNEFS
| ||     . ||| ..|   ..|| ||.| . ..  |.||  | .| |. .   .  ...|||  | .. . |..     ..   | |    .. ..  
dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkek.ttpnvalfvgfvvasrevskkyeqekdap

ILVHCLSGAGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
vivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 62-240 1.6e-13 45.4 In-house 64-221 (255) alignment 
Range on Protein: 62-240
Range on HMM: 64-221/255.0
EacdrvphlllstklqyygisdhKNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTRN---SKTSHTVTQYQFHGWPKHGSdPQLgARSLM
|                      ..   | .|.|     .     |.  .| |  |. .| |..| .    |  |||. |...||... . |.| || ..
e......................egvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna.Pel.areil

KLIRAVKSStnKmnefSILVHCLSGAGRTGVFCTAmECIAQ-----IAE--GDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.....|. |  |    |..||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|  . ||   .. ...
nilkvvrds..k....svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 99-242 6.7e-13 43.0 In-house 152-289 (305) alignment 
Range on Protein: 99-242
Range on HMM: 152-289/305.0
SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPqlGARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIA
||.| | .   . .... ..|  .| .    .... ||.| .  ||  |  .     ....|.   ..|        | ||| .| ||||        . 
svkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarpskg.....pivvhcsagigrtgsvvmleyild

QIAEGDSVDIFQ-TVKILRADRMQFVQTEEEYAFVYDVIREYLHT
|. .|. ..  .  .. .| .| . .||...| ||..|| .|.. 
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_ptpA1_pd Subfamily ptpA1 98-196 8.3e-13 42.8 In-house 151-252 (418) alignment 
Range on Protein: 98-196
Range on HMM: 151-252/418.0
NSVqFGSYSVSTLSTSSDGD--MTIRQLKVTRNSKTsHTVTQYQFHGWPKHGS-DPQLGARSLMKLIRAVKSS--TNKMNEFSILVHCLSGAGRTGVFCT
| | ||.|||  .    | .  .  |....| . .| . .||||. ||| |   |     | |.. |   .     .   .  |.||| .| |||| |||
nev.fgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct

AMEC
|.  
avim
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 86-232 3e-12 40.6 In-house 129-280 (302) alignment 
Range on Protein: 86-232
Range on HMM: 129-280/302.0
NARSCAQYWPDA--NSVQFGSYSVSTLSTSSDGD-------MTIRQLKVTR---NSKTSHTVTQYQFHGWPKHGSdPQLgARSLMKLIRAVKSStnKMne
. . ||.|. |   . ..|| |.| |.|   | .       ... .....    ..|. .||   .| .||.||. |.  | . .....  .|   |   
eekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGa.pke.aytaldilkfcesy..kk..

fSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFV
 ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   ..
.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 85-232 3.3e-12 40.9 In-house 71-219 (263) alignment 
Range on Protein: 85-232
Range on HMM: 71-219/263.0
KNARSCAQYWPDANSVQFGSYSVSTLSTSSDGDMTIRQLKVTR---NSKTSHTVTQYQFHGWPKHgSDPQLgARSLMKLIRAVKSStnKmnefSILVHCL
..   | .|.|     .     |.  .| .  |. .. |...    . |. |||..|.. ||...  ||.| ||. ........ |  |    |. ||| 
egvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek.ndpel.areilnilkvarns..k....slvvhcs

SGAGRTGVFCTAmECIAQ-----IAEGD--SVDIFQTVKILRADRMQFVQTEEEYAFV
.| ||.  |  | | . |     . . .   .|  . .. ||  | . ..|    || 
tGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 112-244 7.8e-12 39.5 In-house 154-280 (312) alignment 
Range on Protein: 112-244
Range on HMM: 154-280/312.0
TSSDGDMTIRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDPQlgARSLMKLIRAVKSSTNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQ
  |   .| | |||  ..      . .||.  || ||        . ..|. |||   .      .. || .| |||| ..     || .      .. .
gkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds..cdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkd

TVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.  .|| || . |..  .| ..  .. |.|... 
sfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 138-241 2.1e-11 37.8 In-house 186-286 (302) alignment 
Range on Protein: 138-241
Range on HMM: 186-286/302.0
YQFHGWPKHGSDpqLGARSLMKLIRAVKSSTNKMNEFSiLVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
| .. |...         .|.| .  |  .. | .| . ..    |||| |.| |..  . .. .|. . | ..|| .|..| . |.. . |...| .. 
yvltnWkqkkvp..vkyaeliktaakvfakkikadent.vivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

EYLH
 |. 
lyik
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 172-236 6.6e-11 36.6 In-house 227-291 (297) alignment 
Range on Protein: 172-236
Range on HMM: 227-291/297.0
NEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 .  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. ..||..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 134-240 2.7e-10 34.5 In-house 216-344 (350) alignment 
Range on Protein: 134-240
Range on HMM: 216-344/350.0
TVTQYQFHGWPKHG--SDPQLGARSLM---KLIRAVKSS--TNKMNEFSILVHCLSGAGRTGVFCTAMECIA------QIAEG---------DSVDIFQT
 | | |.. |.  .   .|.   ..|    .||    .    .. .  .||||| .| ||||...|    .       .. .              |...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKILRADRMQFVQTEEEYAFVYDVIREYL
|..||  |.. ||. . . |.|. .. | 
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 133-250 3.5e-09 30.7 In-house 171-289 (303) alignment 
Range on Protein: 133-250
Range on HMM: 171-289/303.0
HTVTQYQFHGWPkHGSDPQLGARSLMKLIRAVKSSTNKMNEFSILV-HCLSGAGRTGVFCTAM-ECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
  .  .... || |.| |  |.  ..| |  ..|   |  . .  |   ||| ||.| |.      ..  .|  |.|. . .. .|  |.. ||   ...
sflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfs

FVYDVIREYLHTENYEQLPY
.|| .. |..  . . .|  
vvytllaehvldngicklai
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 104-240 5.9e-09 29.0 In-house 175-309 (346) alignment 
Range on Protein: 104-240
Range on HMM: 175-309/346.0
SYSVSTLSTSSDGDMTIRQLKVTRNSKTSHTVTQYQFHGWPKHGSDPQLgARSLMKLIRAVKSStNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEG
   .    .   ||     ..|  . ..   . | . |   ||  .|   .  ..|.|   .|  .....  . |  | |.||.  |  |.  | |. .|
kmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppk.tlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnng

DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
   .|.. .| .. .|   |..  .|| .| .. .|.
iepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_eak_pd Subfamily eak 91-244 2.8e-08 27.5 In-house 136-309 (332) alignment 
Range on Protein: 91-244
Range on HMM: 136-309/332.0
AQYWPDAN--SVQFGSYSVSTLSTSSDGDMTIRQLKVTRNSKTsHTVTQYQFHGWPKHGSD------------PQLGARSLMKLIRAVKSSTNKM-----
 .|.||     ..|| . | . .    . .  |.|....  .| | |  |...|| .                 . |.  |.    |. ||| |      
dkyfpdktreelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtp

NEFSILVHCLSGAGRTGVFCTAMECIaQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
  |. .. .  |. |.|||      | .. ..    .  . . .   .  |.  | .. ...|.|... .|| . |
psfapiiqsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_egg_pd Subfamily egg 75-238 3.7e-08 27.4 In-house 107-268 (307) alignment 
Range on Protein: 75-238
Range on HMM: 107-268/307.0
KLQYYG-ISDHKNARSCAQYWPDAN--SVQF--GSYSVSTLSTSSDGD--MTIRQLKVTRNSKTSHTVTQYQFHgWpKHGSDpqlgARSLMKLIRAVKSS
. ||   ..  |..  |  ||| |.  |...  ||. . .|   |  |  ... .||.    .    .  .|   . .. ||      | ....| ..  
evqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.v.nnssd....vysplrvlrklrnl

TNkmnefSILVHCLSGAGRTGVFCTAMECIAQIAEGDS--VDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
..      ..|..  |  ..... ..   . ..  |      . ..|. ||  |   |..   | ||| ..  
sk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 127-240 5.7e-08 26.4 In-house 212-344 (349) alignment 
Range on Protein: 127-240
Range on HMM: 212-344/349.0
RNSKTSHTVTQYQFHGWPKHGSdpQLGARSLMKLIR-------AVKS--STNKMNEFSILVHCLSGAGRTGVFCTAMECIA--QIAEGDSVD--------
 ...  . . | |.  |.  .    |   |... .           .    .. .  ..|||| .| |||||..|    ..  .  . .|.         
lavekPyellqlqvknwldlsl..llnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk

--IFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |. .| .||  |.. ||   .. ..|. . .|.
DlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_PTPDC1_pd Subfamily PTPDC1 152-235 1.3e-07 26.2 In-house 93-171 (182) alignment 
Range on Protein: 152-235
Range on HMM: 93-171/182.0
LGARSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCTAMECIAQIAEGDsvdifQTVKILRADRMQFVQTEEEYAFVYDV
 |..|| ...  ||  .  ..|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .| . 
ygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvkef
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 86-237 1.4e-07 25.3 In-house 146-299 (332) alignment 
Range on Protein: 86-237
Range on HMM: 146-299/332.0
NARSCAQYWPDANSV-QFGSYSVSTLSTSSDGDMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSDPQ--LGARSLMKLIRAVKSSTNKMNEFSILVHCLS
.|. | ..||. .|  .| . |. .    |.  |   .| || . |  |     .|. |      |.  |  |. .||     |    .    |.. | .
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtek.kqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GAGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
|  .  ...|    ...|.|   | . .|.  .. .|.  ..|   |.   ... 
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlm
0038934 (Phosphotyrosine protein) phosphatases II 141-192 6.5e-07 24.7 In-house 83-134 (194) alignment 
Range on Protein: 141-192
Range on HMM: 83-134/194.0
HG--WPKHGSDPQLgaRSLMKLIRAVKSSTNKMNEFSILVHCLSGAGRTGVFCT
.   .| .|. |.|    |.. ...|.  .|. ..  ..|||  | ||||... 
lklpfpddgtvPsl..eillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 88-149 2.1e-06 21.8 In-house 116-180 (297) alignment 
Range on Protein: 88-149
Range on HMM: 116-180/297.0
RSCAQYWPDAN--SVQFGSYSVSTLSTSSDG--DMTIRQLKVTRNsKTSHTVTQYQFHGWPKHGSD
  || |||...    . |.. |  ||. ||    . . .|..    . |  |.  || .|| ||  
dkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvp