Gene SpurPTP-sf2-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP096_AA protein Get Run
SpurP096_AA_325-514 phosphatase_domain Get Run
SpurP096_AA_531-758 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 320-759 0.0 1056.4 In-house 1-440 (440) alignment 
Range on Protein: 320-759
Range on HMM: 1-440/440.0
HSQRPIIVADFADYVQNNRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIESRTLKQYHYQGWP
|||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hsqrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesrtlkqyhyqgwp

DKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCGDTL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
dkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdtl

ILEDDITERVEQIQWPNPHTDKSPLQQEFEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKTCSIYWPVNTRSVTFGPFTVGHKGSEN
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
iledditerveqiqwpnphtdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsen

MNRVKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVLQLMDYLHKCEIQRSTEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNN
||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
mnrvkvrtlelkykeevheirqfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnn

DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTL
||||||||||||||||||||||||||||||||||||||||
dgaidvfqnlrllrlsrpnfvptltdyllcykllthhhtl
0040438 (Phosphotyrosine protein) phosphatases II 337-548 9.1e-57 188.1 In-house 16-311 (317) alignment 
Range on Protein: 337-548
Range on HMM: 16-311/317.0
NRrsRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGI-------------------------------
.   .|...|.  |.|    . ..|.||.|| ||||..|| |||||| |  ..|..|||||||||..|                                
df..talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

--------------------------------------------------------ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkAGNGPL
                                                        ||||....|| |||| |||.   ..|.... |.|..|  ..||.
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpv

LVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEF
||||||| ||||..||.. .|.  ..  ..|... .. .|. ||..||||||| |...|.|| |....||.   .   .. ... | ...| .. ..|.
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekel
0050432 (Phosphotyrosine protein) phosphatases II 319-516 6.8e-56 185.2 In-house 20-302 (308) alignment 
Range on Protein: 319-516
Range on HMM: 20-302/308.0
SHSQRPIIVADFADYVQNNRRSRAFEDEWSLLPSGLSQPS-QIASLPNNKVKNRYRNILAYDHSRVMLeevkGvPDSDYINASYINGI------------
..|  .. | |.. ....   .  .| |.  |.|    ..  .|.||.|| ||||..||.|||||| |    . ..||||||||..|             
lvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatq

--------------------------------------------------------------------------------ESRTLKQYHYQGWPDKGVPK
                                                                                ||||....|| .||| ||| 
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

FAGPVLKMIQDVNESQekaGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCG
 . ..|.... |..|.   ..|| .|||||| ||||..||.| .|.  ..   .|.|. .. .|  ||.|||||||| |...|.|| |.. 
speilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0051299 (Phosphotyrosine protein) phosphatases II 341-513 1.1e-54 181.2 In-house 23-286 (288) alignment 
Range on Protein: 341-513
Range on HMM: 23-286/288.0
RAFEDEWSLLPSGLSQPS-QIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING-----------------------------------
  ...|.  |.| | ...  .|.||.|. ||||..||.|||||| |  ..||..|||||||||.|                                   
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

--------------------------------------------------------IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkAGNGP
                                                         |||| ...|| .||| |||  . ..|.....|..... .|.||
ltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggp

LLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGL
 .|||||| ||||..||.| .|.  ..   .|...... .|. ||.|||||||| ||.||.|| |
vvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 344-517 4.2e-54 179.2 In-house 3-278 (284) alignment 
Range on Protein: 344-517
Range on HMM: 3-278/284.0
EDEWSLLPSGLSQ---PSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGV-PDSDYINASYINGI----------------------------------
|.|.  |.|       .  .| ||.|. ||||..||.|||||| |  ..|  .|||||||||..|                                   
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

------------------------------------------------------------ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEK-A
                                                            ||||....|| .||| |||  . ..|.....|.|..|.  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNGPLLVHCSAGAGRTGVIIAVDSILREAKRSD---QIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCGD
|.|| .|||||| ||||..||.| .|.  .. .    .|... .. .|. ||.||||.||| ||.||.|| |... 
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 333-517 9.2e-53 175.0 In-house 24-293 (297) alignment 
Range on Protein: 333-517
Range on HMM: 24-293/297.0
YVQNNRRSRAFEDEWSLLPSGLSQpSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGV-PDSDYINASYINGIES------------------------
 . .   .  .. |.  |.|       || ||.|| ||||..||.|||||| |  ..|| .|||||||||..| .                         
llekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

------------------------------------------------------------RTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKA-GN
                                                            ||.....| |||| |||  .  .|.... |.| .... ..
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

GPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCGD
|| ||||||| ||||..|| . .|.  ..  ..|... .. .|. ||..||||.|| |...|.|| |....
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 334-512 5e-52 172.9 In-house 20-303 (307) alignment 
Range on Protein: 334-512
Range on HMM: 20-303/307.0
VQNNRRSRAFEDEWSLLPSGLS---QPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGV-PDSDYINASYI---------------------------
..       .. |.  |.|       .  ||.||.|| ||||..||.|||.|| |  ..|  .|||||||||.                           
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

----------------------------------------------------------------------NGIESRTLKQYHYQGWPDKGVPKFAGPVLK
                                                                         ||||....|| |||| |||..  ..|.
vedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

MIQDVNESQEKA-GNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQ---IDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEG
.|. |.. .|.  ..|| ||||||| ||||..|| . .||  ..      .|... .. .|. ||..||.|||| |..||.|| 
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0036941 (Phosphotyrosine protein) phosphatases II 349-520 6.9e-52 172.0 In-house 22-284 (297) alignment 
Range on Protein: 349-520
Range on HMM: 22-284/297.0
LLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLeevkGVPDSDYINASYINGIE------------------------------------------
|||  |. .  .|.||.|. ||||..||.|||.|| |    . ..||||||||..| .                                          
llpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

-------------------------------------------------SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKA-GNGPLLVHCSAG
                                                 |||....|| |||| |||  . ..|..|. |.. .... ..|| |||||||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

AGRTGVIIAVDSILREAK---RSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCGDTLI
 ||.|..||.| .|.  .   .  ..||.......|. ||..|||.||| |..||.|| |....| .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0043336 (Phosphotyrosine protein) phosphatases II 340-511 1.4e-51 170.9 In-house 19-275 (278) alignment 
Range on Protein: 340-511
Range on HMM: 19-275/278.0
SRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGI----------------------------------
 .... |.  |.|    .  || ||.|| ||||..||.|||||| |. ..|..|||||||||..|                                   
ktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivm

----------------------------------------------------ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkAGNGPLLVHC
                                                    ||||  .||| |||| |||    ..|.....|.| .|   |||.||||
LtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHC

SAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLE
||| ||||..||.. .|. ...   .|... .. .|. ||..||||.|| |..||.||
saGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0047943 (Phosphotyrosine protein) phosphatases II 340-512 6.1e-51 168.8 In-house 11-271 (273) alignment 
Range on Protein: 340-512
Range on HMM: 11-271/273.0
SRAFEDEWSLLPSGL-SQPSQIASLPNNKVKNRYRNILAYDHSRVMLeevkGVPDSDYINASYING----------------------------------
.. .. |. ||.|   . . ..|.||.|| ||||..||.|||||| |    | ..||||||||..|                                  
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

--------------------------------------------------------IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKA-GNG
                                                         |||| ...|| |||| |||    ..|..|..|.. .|.. .||
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

PLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEG
| .|||||| ||||..||.| .|.  ..  ..|... .. .|. || |||||||| |..||.|| 
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPRD_pd Subfamily PTPRD 406-549 1.6e-50 167.3 In-house 175-317 (564) alignment 
Range on Protein: 406-549
Range on HMM: 175-317/564.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQeKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|||. .|.|.  |||.|||..| ..|..|..|.... . ..||..|||||| ||||. |..|..|. .| ....||..... .|..|. ||||.|||.|.
esreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFi

HEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
|||.|| | ||.| .  ...........  ...|. . |..||.
heailealacgntevesenlkqhlqkLaeveedtemtgleleFq
0040439 (Phosphotyrosine protein) phosphatases II 359-513 1.9e-48 160.6 In-house 4-246 (249) alignment 
Range on Protein: 359-513
Range on HMM: 4-246/249.0
QIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING------------------------------------------------------
 .|.||.|| ||||..||.|||||| |. ..|...|||||||||.|                                                      
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

---------------------------------IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKA-GNGPLLVHCSAGAGRTGVIIAVDSIL
                                  |||| ....| .||| |||..  ..|..|. |.. .|..  .||.||||||| ||||..|| . .|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

REAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGL
.  ..  ..|... .. .|. ||..||.|||| |..||.|| |
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 360-511 2.6e-48 160.0 In-house 3-241 (245) alignment 
Range on Protein: 360-511
Range on HMM: 3-241/245.0
IASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYI---------------------------------------------------------
.|.||.|| ||||..||.|||.|| | ...| .|||||||||.                                                         
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

------------------------------NGIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILRE
                                 |||.  .||| .||| |||     .|.... |.. ... .|||.||||||| ||||..||.. .|. 
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

AKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLE
...   ..... .  .|. ||..||||.|| |..||.||
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 547-755 1.7e-47 157.7 In-house 28-284 (288) alignment 
Range on Protein: 547-755
Range on HMM: 28-284/288.0
EF--------------------------------------------------------EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN
||                                                        .|| .|..||||| ||..|| ||||.|.......|.||..| 
efeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklv

DK---TCSIYWPVnTRSVTFGPFTVGHKGSENMNRVKVRTLELK------YKEEVHEIRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLHkceiqr
..   .|  |||    |.|.|..||  .  | .. ..|||||..      ...|......| . .||     .|| .  |...| . .....|       
elgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp....dhgvpdspellldflrlvrkala......

steqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
        .|.|..|||  |.  .|.|...  .||||.. | .||.. .. ||  ||. |.|.  |...|..| .
.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 550-757 2.3e-47 157.2 In-house 101-299 (308) alignment 
Range on Protein: 550-757
Range on HMM: 101-299/308.0
GY--SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVN--TRSVTFGPFTVGHKGSENMNRVKVRTLELKY--KEEVHEIR
||   ....||||| ||..|| ||||.|.......|.||..| .   ..|  ||| .    |...|.||| ..  |... ..||||||..  ..|.....
gyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvt

QFEVQTWPtwiqSDGVQSQeqcMDAVLQLMDYLHKCEiqrsteqsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFV
.|   .||     .|| ..   ....|.......|.            .|.||.|||  |.  .|.|...  .||||. .| .|||. .. ||  ||. |
hfhytnWp....dhgvPps...peilldflelvrksl...........pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmv

PTLTDYLLCYKLLTHHH
.|.  ||..|..| .. 
qtpeqylflyralleyl
subfamily_PTPRD_pd Subfamily PTPRD 549-756 1e-46 154.8 In-house 85-280 (564) alignment 
Range on Protein: 549-756
Range on HMM: 85-280/564.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELK--YKEEVHEIRQFE
.|| |..|.|||| || .|. ||||.| ....|||.||..|..|    |. ||| .. . |.| .||  . .|... . .||..||   ..|..|.||| 
dgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFh

VQTWPtwiqSDGVQSQEqcmDAVLQLMDYLHKCEiQrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
   ||    . ||  .     ..|.|..  .... .         |  ||.||| .|.. .|.|...  .||...... .|..| ...||  |.  | | 
FtsWP....dhgvpesa...tslLdlirkvraln.e........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte

TDYLLCYKLLTHH
. |  ... . . 
eQYiFiheailea
0046845 (Phosphotyrosine protein) phosphatases II 550-757 1.1e-46 154.9 In-house 67-274 (284) alignment 
Range on Protein: 550-757
Range on HMM: 67-274/284.0
GY-----SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEEVHE
||      .|..|||||.||..|| ||||.|.......|.||..| ..    |. ||| .  ..|.|.|||  .  |... ..||||||..   ..|...
gydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrt

IRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLHKceiqrsteqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDG---AIDVFQNLRLLRL
...| . .||     .|| .  |. .. . .. ..| .            ..|.||.|||  |.  .|.|.... .||||...|    .||.. .. || 
vthfhytswp....dhgvppspedlleflrlvrellen...........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre

SRPNFVPTLTDYLLCYKLLTHHH
 ||..| ||  |...|..| .. 
qRpgmvqtleqyrfvyealleyl
0045098 (Phosphotyrosine protein) phosphatases II 345-517 2.5e-46 153.7 In-house 12-276 (278) alignment 
Range on Protein: 345-517
Range on HMM: 12-276/278.0
DEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMleevkgvpdsDYINASYI------------------------------------------
. . ||. |  .    | ...|. ||||..||.||||||           ||||||||                                          
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-----------------------------------------------NGIESRTLKQYHYQGWPDKGVPKFA--GPVLKMIQDVNESQE-----------
                                               ...|||.....|| .||| ||| .    ..|.... ..| ..           
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

-KAGNGPLLVHCSAGAGRTGVIIAVDSILREAkrSDQIDIFSFINSMRNNRPQ-MVQTPEQYAFVHEAVLEGLLCGD
   ..|| ||||||| ||||...|.. .|.     ...|... .. .|. ||. .||..||| |..|..|| ||.|.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0036941 (Phosphotyrosine protein) phosphatases II 548-756 6.7e-46 152.3 In-house 19-276 (297) alignment 
Range on Protein: 548-756
Range on HMM: 19-276/297.0
F----------------------------------------------------EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---K
|                                                    .||. |..||||| ||..|| ||||.|.......|.||..| .   .
feellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

TCSIYWPVN-TRSVTFGPFTVGHKGSEN--MNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLHKCeiqrsteqsr
.|  ||| .   |.|.|.|||  .. |    . ...||||...  ..|......| . .||     .|| .  ....| . .. ..|..           
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp....dhgvpespaslldfielvrkvlkll..........

pGDGPPILVHCLSGIEESGVFCTVMNCLEQLN---NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
  .|.|.||||  |.  ||.|...  .|.||.     | .|... .. ||  ||. |.||  |. .| .| ..
.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 549-754 4.2e-45 149.3 Pfam-A 36-234 (235) alignment 
Range on Protein: 549-754
Range on HMM: 36-234/235.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWP-VNTRSVTFGPFTVGHK-GSE-NMNRVKVRTLELKYKEEV---HEI
.||..|..|||||.||.||. ||||.| ......|.||..|..|   .|. |||  . .|.|.| ..|  |  .. ..... .|.|||| |.|    .|.
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

RQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLHKCEiqrsteqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNF
.|. ...|| .          .. ...|.|.. ..| .           .  |..|||  |.. .|.|.... .||||.... .||.| .. || .||. 
kqlhytnWpdhg.......vpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm

VPTLTDYLLCYKLLT
| .|. |  .||...
vqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 549-754 4.2e-45 149.3 In-house 36-234 (235) alignment 
Range on Protein: 549-754
Range on HMM: 36-234/235.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWP-VNTRSVTFGPFTVGHK-GSE-NMNRVKVRTLELKYKEEV---HEI
.||..|..|||||.||.||. ||||.| ......|.||..|..|   .|. |||  . .|.|.| ..|  |  .. ..... .|.|||| |.|    .|.
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

RQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLHKCEiqrsteqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNF
.|. ...|| .          .. ...|.|.. ..| .           .  |..|||  |.. .|.|.... .||||.... .||.| .. || .||. 
kqlhytnWpdhg.......vpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm

VPTLTDYLLCYKLLT
| .|. |  .||...
vqsleqYiflykail
0047943 (Phosphotyrosine protein) phosphatases II 549-755 9.9e-45 148.5 In-house 71-270 (273) alignment 
Range on Protein: 549-755
Range on HMM: 71-270/273.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTR--SVTFGPFTVGHKGSENMNRVKVRTLELKY--KEEVHEIRQ
.|| .|..|||||.||..|| ||||.|.......|.||..| ..   .|  ||| .    |.|.|.||| ... |. . ..||||||..   .|......
dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvth

FEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLHKC--EiqrsteqsrpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPN
| . .||     .||  | |.... . .....|...  .             .|..|||  |.  .|.|...  .|.||.  | .||.. ..|||  ||.
fhytgwp....dhgvppslesllefielvrkalealpsn.............gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg

FVPTLTDYLLCYKLLTH
 |.|.  |...|..| .
mvqtpeqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 549-755 1.5e-44 147.4 In-house 93-288 (298) alignment 
Range on Protein: 549-755
Range on HMM: 93-288/298.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE--EVHEIRQFE
..|...||||||| || .|| ||||.| ...|.||.||..|...   ... ||| . .. |.| .||  . .|..  . ||.|... |.  . .|.||..
haykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlh

VQTWPtwiqSdgvQSQEQCMDAVLQLMDylhkcEIQRSTEQSrpGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
. .||    .   ..  . . .||.|..     ....|..|.  |.  |..|.| .|.. || |. .   ||.....  .|||| .. || .||. | | 
ftsWp....d...kgvpenatsvldllr.....kvrasqqqa..gnk.pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

TDYLLCYKLLTH
..|  .|..  .
eqYvfiyeavle
0040438 (Phosphotyrosine protein) phosphatases II 549-757 2.3e-44 147.3 In-house 80-276 (317) alignment 
Range on Protein: 549-757
Range on HMM: 80-276/317.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVnTRSVTFGPFTVGHKGSENMNRVKVRTLELK--YKEEVHEIRQFE
.|...|..||||| ||..|| ||||.|.......|.||..| ..   .|  |||    ..|.|.||| ... | .. ...||||..  ...|......| 
dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLhkceiqrsteqSrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
  .||     .||  | ... | . .. ..|           .  ..| |.||||  |.  .|.|...  .||||.  | .||.. .. ||  ||. |.|
ytgWp....dhgvppspdllldfleavreal...........e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqt

LTDYLLCYKLLTHHH
.  |  .|..| ...
peqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 532-756 3.8e-44 146.7 In-house 22-288 (297) alignment 
Range on Protein: 532-756
Range on HMM: 22-288/297.0
IQWPNPHTDKSPLQQEFEGYSK--------------------------------------------------------KNAFIATQMPLDSTVLDFWRLV
... .. ..|. |..||| . .                                                        ...||||| ||..|| ||||.|
llllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

HDYHISTIIMLNQLNDKT--CSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDY
.......|.||..|...   |  ||| ..   |.|.|||  .. |  . ..|||||.....|......| .  ||     .||  | |...... .....
weqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp....dhgvppslellleflelvrea

LHKCeiqrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
| ..           ..| |.||||  |.  .|.|..   .||||.  | .||.. .. ||  ||. |.|.  |  .|..| ..
lael...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 406-549 5.2e-44 145.6 In-house 173-316 (318) alignment 
Range on Protein: 406-549
Range on HMM: 173-316/318.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|||. .||||  |||.|||. .. .|.....|.. |.|.|.||..|||||| ||||| ||||..|. .|    .|.| ... .|..|. |||| .|| |.
esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefi

HEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
....|| | .||| .  .|...|..... ..|.. ..... ||.
ydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
0045450 (Phosphotyrosine protein) phosphatases II 541-755 1.1e-43 145.5 In-house 26-302 (307) alignment 
Range on Protein: 541-755
Range on HMM: 26-302/307.0
KSPLQQEF-------------------------------------------------------------------EGYSKKNAFIATQMPLDSTVLDFWR
.. |..||                                                                   .|| .|..||||| ||..|| ||||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LVHDYHISTIIMLNQLN---DKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELK---YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAV
.........|.||..|    .. |  ||| .  ..|.|.|||  .. | .. ..|||||..   ...|......|   .||     .||  | |.. | .
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp....dhgvppsfeelldfi

LQLMDYLHKceiqrsteqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGA---IDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
 .....|..            ..| |.||||  |.  .|.|..   .|.||...|    .|... ..|||  ||. |...  |  .|..| .
eevrkalee...........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 404-548 2.8e-43 143.2 In-house 174-318 (319) alignment 
Range on Protein: 404-548
Range on HMM: 174-318/319.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYA
 .|.|..|...|. |||..||. |  .|........|.||  .||. ||||||.||||  |..| .|   |.   .|.||... .|  |. |||.|||| 
evetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYk

FVHEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEF
|..||.|| . .||| |  .|. .|. |..  .. | .. |..||
fiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 552-755 3.8e-43 142.8 In-house 88-286 (325) alignment 
Range on Protein: 552-755
Range on HMM: 88-286/325.0
SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN--DKTCSIYWPVN-TRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE--EVHEIRQFEVQT
 ||. |.|.|.|| .|. |.|||| |.. | ...||.|.  .. |..||| .   |.|||.. |  .  |..     | |..|  .  |   ..||..|.
kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqs

WPTWiqsdGVQSQEQCMDAVLQLMDYLHKCeIQRSTEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDY
|.      ||| .  .. ..|||.. .... ..  |. |      |||||| .|.  .||| ..   |... ..  .|.|. .. ||  ||. | |   |
wddm....Gvqkrpatlisilqlvkavser.vtantkast.....pilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqy

LLCYKLLTH
 |.|. |. 
iliyealve
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 404-549 5.7e-43 141.9 In-house 169-313 (315) alignment 
Range on Protein: 404-549
Range on HMM: 169-313/315.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESqEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYA
. ||||. |.....||||||.| .. .||.|..|  . ..  . .||||||||.|||||.|..|... ..||.. .|.| |.. .|..||..||| |.||
seesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

FVHEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
|...|||| ||  .||||   .|.......     . .| . .|||
fiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefe
0043336 (Phosphotyrosine protein) phosphatases II 549-755 1.5e-42 141.4 In-house 82-275 (278) alignment 
Range on Protein: 549-755
Range on HMM: 82-275/278.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPvnTRSVTFGPFTVGHKGSENMNRVKVRTLELK--YKEEVHEIRQFE
.||.....||||| ||..|| ||||.|......||.||..| ..   .|  |||    |.|.|.|||  .. | .. ..|||||..  .. |....... 
dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyh

VQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLhkceiqrsteqsRpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
   ||     .||  | .. .| . .....|            .  .. |.||||  |.  .|.|...  .||||.. | .|... .. ||  ||. |.|
ylgwp....dhgvpeslsllldflkavreal............e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqt

LTDYLLCYKLLTH
.  |  .|..| .
psqyrflyealle
DSPc_SM00195 549-754 1.6e-42 141.0 In-house 63-259 (263) alignment 
Range on Protein: 549-754
Range on HMM: 63-259/263.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSENMN-RVKVRTLELKYKE--EVHEIRQ
.|..||...||||.||.||| ||||.| . ....|.||.. ..   ..|. ||| .  .. ||| ..|  .  |...  ...|||||....  | ....|
kgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtq

FEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLHKCEIQRsteqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVP
.....||      ||.....    ||.|. ...|.. .           .||.|||  |.. .|.|.|.  .|..|...  .|.|. .. || .||. | 
yqyknWpdh....gvpdstk...svlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvq

TLTDYLLCYKLLT
||. || .|. . 
tleqYlfiyeail
PTPc_SM00194 549-754 1.6e-42 141.0 In-house 63-259 (263) alignment 
Range on Protein: 549-754
Range on HMM: 63-259/263.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSENMN-RVKVRTLELKYKE--EVHEIRQ
.|..||...||||.||.||| ||||.| . ....|.||.. ..   ..|. ||| .  .. ||| ..|  .  |...  ...|||||....  | ....|
kgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtq

FEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLHKCEIQRsteqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVP
.....||      ||.....    ||.|. ...|.. .           .||.|||  |.. .|.|.|.  .|..|...  .|.|. .. || .||. | 
yqyknWpdh....gvpdstk...svlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvq

TLTDYLLCYKLLT
||. || .|. . 
tleqYlfiyeail
0037934 (Phosphotyrosine protein) phosphatases II 359-511 2e-42 140.8 In-house 3-240 (243) alignment 
Range on Protein: 359-511
Range on HMM: 3-240/243.0
QIASLPNNKVKNRYRNILAYDHSRVMLeevkgvPDSDYINASYI--------------------------------------------------------
 ||.||.|. ||||..||.|||||| |      ..||||||..|                                                        
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpg

-------------------------------NGIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEK-------AGNGPLLVHCSAGAGRTGVII
                                . ..|.  .||| .||| |||    ..|.....|.| .|.        ..||.||||||| ||||..|
evtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

AVDSILREAkrsdQIDIFSFINSMRNNRPQ-MVQTPEQYAFVHEAVLE
| . .|.      ..|... .. .|. ||. .||||.|| |..||.||
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 406-532 2e-42 140.4 In-house 176-302 (305) alignment 
Range on Protein: 406-532
Range on HMM: 176-302/305.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
||||. ||.   |||.|||.||. .|..|..|...|.|  . ||||||||| ||||| ||||  |  .|. ...|.|  .. .|..|..|||| .|| |.
esrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl

HEAVLEGLLCGDTLILEDDITERVEQI
|.|. | . |||| |. .... ||...
hdaldelitcgdtsiigsnlrarvnkl
0040439 (Phosphotyrosine protein) phosphatases II 549-755 2e-42 140.9 In-house 48-244 (249) alignment 
Range on Protein: 549-755
Range on HMM: 48-244/249.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENMNRVKVRTLELK--YKEEVHEIRQFE
.||  |..||||| ||..|| ||||......|..|.||..|     ..|  |||    |...| |||  .  | .. ..||||||.  |. |....... 
dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLHKCeiqrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
.  ||     .||  | |...| . .....|...           ..| |.||||  |.  .|.|..   .||||.  . .|... ..|||  ||. |..
ytdwp....dhgvppsfedlldfieavrkaleel...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

LTDYLLCYKLLTH
.  |  .|..| .
peqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 404-549 2.1e-42 139.9 In-house 168-312 (515) alignment 
Range on Protein: 404-549
Range on HMM: 168-312/515.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGnGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYA
| .|||. |.|...|||||||| .  .||.|..|  ....    ||..|||||.|||||.|..||.. .|| .. .|.| |.. .|..||..||| ||||
gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqya

FVHEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
|...|||| ||  .|||    .|. .....       .| . .||.
fiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 549-756 6.9e-42 138.6 In-house 83-282 (305) alignment 
Range on Protein: 549-756
Range on HMM: 83-282/305.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQ---LNDKTCSIYWPVNTRS-VTFGPFTVGHKGSENMNRVKVRTLELKY---KEEVHEIRQ
.||..|...|..| ||..|| |||||. ....|||.|| .    ... |  ||| ...  . ||.|.|  | .....    | |..     ..| . . |
dgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlq

FEVQTWPtwiqSDGVQSQeqcMDAVLQLMDylhkceiqRSTEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVP
... .||     .||  .     ..|.|..        | ... . . | |.||||  |.  .|||..|   ||.|.... .|||. |. || .|.. | 
yqltdWP....dhGvpqf...atsllslik........rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvq

TLTDYLLCYKLLTHH
||  |  ..  |   
tldqYvflhdaldel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 549-756 9.1e-42 138.0 In-house 46-241 (250) alignment 
Range on Protein: 549-756
Range on HMM: 46-241/250.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN--DKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHE--IRQFEV
.||....|||||| || .|. ||||.| .....||.||..|.  .||.. ||||.. . ..|  ||  . .|..  ...|.| |  ... .|  .||.. 
hgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek.aekyGdvtvsllskeefadytkrklklskakkaderivrqlhf

QTWPtwiqsDgvQSQEQCMDAVLQLMDylhkcEIQRSTEQSrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLT
 .||     |  ..  . . |||.|..     ..|.| .|.   .  |..|.| .|.  || |...   ||.|...  .|||. .. ||  ||. | .|.
vvWP.....d..kgvPevatavLellk.....kvqasqqqa...gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesle

DYLLCYKLLTHH
 |  .|... . 
qyvfvyeiilka
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 406-520 3.9e-41 136.2 In-house 183-297 (298) alignment 
Range on Protein: 406-520
Range on HMM: 183-297/298.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
..|...| |.  |||||||. |  ||.....|. ||..||| |..|.|||| ||.|  ||.||.|  .|..  .|.|  .. .|..||..||| |||.|.
kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

HEAVLEGLLCGDTLI
.||||| | .... |
yeavlealdsfndei
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 549-754 1.9e-40 133.7 In-house 86-276 (315) alignment 
Range on Protein: 549-754
Range on HMM: 86-276/315.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNtrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQ
.||.||. .||.| |. ..| ||||||....|..|.||..| .   . .  ||| .   |..|..|| .|  |  ... ||||   ......|. |... 
dGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhyt

TWPTwiqsDGVqsqeqCmDAVLQLMDYLHKCEiQRSTEQSrpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTD
.||.     ||     .    . ||..  .   |  |..       .|.||| .|.  .| |.|.   |.|.. . ||||.. .. .|  | . | ..  
swpd....mgv.....p.kytiplmnlirtvk.qhhtnsv.....gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq

YLLCYKLLT
| . |. | 
yqfiydall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 548-754 2.9e-40 133.1 In-house 83-276 (288) alignment 
Range on Protein: 548-754
Range on HMM: 83-276/288.0
FEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL---NDKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEV
..|. ||...|||| || .|| |||.||.....|||.||..|   ....|  ||| . . . .| .||  ..|.... . .|.|.|. |..  || |.. 
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqy

QTWPtwiqSDGVQSQEQCMDAVLQLMDYLHKCEiqrsteqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLT
..||     .||  ... . ..|. ..  .. .              ||.|||  |.  .|.| .. . .......  |||.  .  || .|...| ||.
laWp....dhgvPeskapllellrqvkvanqad............tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk

DYLLCYKLLT
 |  .|. | 
qYefiyevll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 407-516 1.1e-39 131.1 In-house 136-245 (250) alignment 
Range on Protein: 407-516
Range on HMM: 136-245/250.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
.|...|.|.  |||||||. |  ||.....|. ||..|||.|..|.|||| ||.|  ||.|..|  .|.. ..|.| .|. .|..||..|.. ||| ||.
erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvy

EAVLEGLLCG
|..|. | . 
eiilkaldsv
subfamily_PTPRK_pd Subfamily PTPRK 406-549 1.8e-39 130.4 In-house 171-313 (314) alignment 
Range on Protein: 406-549
Range on HMM: 171-313/314.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKaGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
| |...|... |||| .||. |  .||... |..|||. ..|...|||||||||||. ||.|..|  ..| . .|.|  . ..|.... ||.| ||| |.
eirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

HEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
....||  |||.| |   ..     ...  .|.|. | |..||.
ydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
0042113 (Phosphotyrosine protein) phosphatases II 549-753 6e-39 129.3 In-house 46-239 (245) alignment 
Range on Protein: 549-753
Range on HMM: 46-239/245.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENMNRVKVRTLELK--YKEEVHEIRQFE
 ||  .. ||||| ||..|| ||||......|.||.||... .   ..|  |||    |.|.| |||  .. |... ..|||||..  .. |..|.... 
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VQTWPtwiqSDGVQSQEQCMDAVLQLMDYLHKCeiqrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
   ||     .|| .  . .. .|....   .            ... |.||||  |.  .|.|...  .||||.  . ..... .. ||  ||. |.|.
ylpwp....dhgvpdllellldflefvrkalae...........dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp

TDYLLCYKLL
  |  .|..|
sqyrflyeal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 408-520 6.9e-39 128.7 In-house 177-291 (297) alignment 
Range on Protein: 408-520
Range on HMM: 177-291/297.0
RTLKQYHYQGWPDKGVPK--FAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
| .|||..  |||| |..   |  .||.|..|... ..  .|||||||.|| |||||....||.. |||| ...||| ... .|..||..||| |||.||
rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

HEAVLEGLLCGDTLI
..|||| ||. || |
yvavleallsedtri
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 549-764 1.7e-38 127.5 In-house 85-290 (319) alignment 
Range on Protein: 549-764
Range on HMM: 85-290/319.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEE-V--HEIRQF
.|| ....||||| ||. |. ||||.| ....|...||..|..|    .. ||| .   ...| ..|  .  |... . .| |.|. | . |   |. .|
dgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhf

EVQTWPtwiqSDGVQSQeqcmdaVLQLMDYLHkcEIQRSTEQSrpGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
  . ||     ..|  .       ..|.| |.  .|..|.|..   .| || |||  |.   | |...   ||.....|..|||.  . ||. |.  | .
qyteWp....dhdvPek......atslldllk..rirksrekt..qsg.PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqr

LTDYLLCYKLLTHHHTLCRSEE
   | ..|. | .  .   .| 
peqYkfiyealleaveagdtei
subfamily_PTPRK_pd Subfamily PTPRK 549-753 2e-38 127.0 In-house 80-273 (314) alignment 
Range on Protein: 549-753
Range on HMM: 80-273/314.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKT---CSIYWPVNTRSvtFGPFTVGHKGSENMNRVKVRTLELKY----KEEVHEIRQ
..| . .|||.|| ||..|| ||||||.|.. ..|.||..| ...   |. ||| .|.   .|.. |    .|  . . ||.. ..     .||..|.||
dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrq

FEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLHKCEIQrsteqsrpGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVP
|.  .||..    .|  ...   ..|.|.  ..| . .        ..| .|.|||..|   .|.|...   |. ....| .|||.  . || ...|.| 
fqflgWpdh....dvPvsat...gllklvrrvkksqee........eaG.rivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmve

TLTDYLLCYKLL
|   | ..|  .
teeqykfiydvi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 553-754 2.1e-38 127.1 In-house 90-281 (297) alignment 
Range on Protein: 553-754
Range on HMM: 90-281/297.0
KKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN--DKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKE--EVHEIRQFEVQTWP
 |. .|.|||| ..|| |||..| |...|||.|||..|  || |  ||. .. ..|||  .|  .  .. .    |.||..  .    . ..|..   ||
nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg.vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWP

TwiqsdGVQSQEQCMDAVLQLMDylhkcEIQRSTEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLL
.      .  ... . ..|.|..     |.. . .|   |   |.|||||.|.   ||..|. ... . ... ..|.|. .. || .||..| |  .| .
d.....kaverkdsassllklis.....evrkdfsqnaeg...PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykf

CYKLLT
 |... 
vyvavl
0045098 (Phosphotyrosine protein) phosphatases II 550-756 2.2e-38 127.7 In-house 61-271 (278) alignment 
Range on Protein: 550-756
Range on HMM: 61-271/278.0
GYskKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPvNTRSVTFGPFTVGHKGSENMNRVKVRTLELK------YKEEVHEIR
||  ...||||| ||.||| ||||......|..|.||..| ..    |  ||| .  |.|.|.|||  .  |... . .|||..       .  | ....
gy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvt

QFEVQTWPTWIQSDGV--QSQEQCMDAVLQLMDYLHKCeiqRSTEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLnnDGAIDVFQNLRLLRLSRPN
..   .||     .    .|  .... ... ...|..     ... .  ..| |.||||  |.  .|... .. .||.|  .| .|... .. ||  ||.
hlhylpwpdhgvpslpilksflellefirealkllasl...llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpg

-FVPTLTDYLLCYKLLTHH
  |..|  |  .|..| ..
lavqnleqyrflyefllel
subfamily_PTPRA_pd Subfamily PTPRA 407-548 6.1e-38 125.5 In-house 190-330 (330) alignment 
Range on Protein: 407-548
Range on HMM: 190-330/330.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNgPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
|| ..|.|...||| |||  .  .||... |.. ... .. |. ||||||.||||  |..|..|   |   ..|.| |....|..||||||| ||| |..
srlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiy

EAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEF
...||  | ||| .    . .......   ..|||  |..||
kvlleyylygdteldvsslekhlqklynkitgtdkigleeef
subfamily_PTPN12_pd Subfamily PTPN12 406-511 7.4e-38 125.1 In-house 168-275 (290) alignment 
Range on Protein: 406-511
Range on HMM: 168-275/290.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkAGNGPLLVHCSAGAGRTGVIIAVDSI---LREAKRSDQIDIFSFINSMRNNRPQMVQTPEQY
|||...|.||. |||.|||. | ..|..|..|.| || . . ||.|||||| ||||.|||.| .   |.. | ....|.|. . ..|..|. .||| |||
esrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

AFVHEAVLE
 .|..||.|
elvykavae
subfamily_PTPN9_pd Subfamily PTPN9 548-754 2.4e-37 123.6 In-house 78-287 (297) alignment 
Range on Protein: 548-754
Range on HMM: 78-287/297.0
FEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELK--YKEEVHEIRQ
 .|| .|.|||||| ||. || ||||.| . .. .|.|  .. ..    |. |||  .  |  || ..| .   |...  |||.||.|   .||  ..  
vdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth

FEVQTWPTWiqsdGVQSQEQCMDAVLQLMDYLHKCEIQRSTEQS-RPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFV
| . .|| .    || |. . .  ||. .     . ..  ....  . .||||.||| .||  .| |.|.  ||..|.. | .||.. ..|||  |   .
fqflsWPdy....GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi

PTLTDYLLCYKLLT
 |   | .||. . 
qtpeqyefcylavl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 548-753 3.9e-37 122.8 In-house 80-273 (315) alignment 
Range on Protein: 548-753
Range on HMM: 80-273/315.0
FEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL--NDK-TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFE
.... . .|.||.|.||...| ||||.| .....||.|....  .||  |  |||  .. || || . |     |      .| | ..  || . . ||.
iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfq

VQTWPTwiqsDGVQSQEQcmdAVLQLMDylhkcEIQRSTEQsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
 . ||      ||. |     ..|.|.      |.. . ..    .  ..||||..|.  .||.........|...  ..|||. .. ||  || .| | 
ftewPd....kGvdkqts...sllklik.....evkadngk....kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte

TDYLLCYKLL
 .| . |  .
eeyafiydav
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 549-756 6.4e-37 122.3 In-house 83-279 (318) alignment 
Range on Protein: 549-756
Range on HMM: 83-279/318.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPvNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE--EVHEIRQFE
.|| .|.|.||.| ||  |. ||||.| . . ..|.|| |....    .  ||| .  | ..|  .|  | . ...   .|..... .|  |. ..||..
dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyh

VQTWPtwiqSDGVQSQEqcmdavLQLMDYLHKCEIQrsteQSRPgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
. .||      || ..        .|.| . . .      | .. .  ||.||| .|.   |||..|   ||...... .||||  . ||  |.  | | 
ytsWp....degvpesg......aslldlvrqvska....qqks.gagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

TDYLLCYKLLTHH
  | ..|. |.  
dqyefiydvllea
subfamily_PTPRA_pd Subfamily PTPRA 549-763 9.1e-37 121.6 In-house 95-301 (330) alignment 
Range on Protein: 549-763
Range on HMM: 95-301/330.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELK------YKEEVHEI
.|| .|. |||.| |.. || ||||.. ... .||.|| .|..   . |  ||| .  .||.|  .|  . .. .. . || . ..       ....  .
dGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlv

RQFEVQTWPTWiqsdGVQSQEQCMdavLQLMDYLHKCEIQRsteqsrpGDgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNF
|||  ..||      || .. . |   |.|.  ..|.. |        ..  || ||| .|.  .| |... . ||... .. .|||. .. ||| ||. 
rqfhftswPdv....GvPfepiGm...lkllkkvkklnqqs.......ag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqm

VPTLTDYLLCYKLLTHHHTLCRSE
| |.  | ..|| | ...    .|
vqtdeqyefiykvlleyylygdte
subfamily_PTPRB_pd Subfamily PTPRB 406-511 1.1e-36 121.4 In-house 177-283 (293) alignment 
Range on Protein: 406-511
Range on HMM: 177-283/293.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQ-EKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAF
|.|...|||.. ||| |||. . ..|.... |.|.. ..| ..|..|||||| ||||. ||.| .|.. ...| .|||... ..|..| ..||| .|| |
eerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYif

VHEAVLE
.|..||.
ihqcvld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 408-549 2.2e-36 120.4 In-house 175-315 (315) alignment 
Range on Protein: 408-549
Range on HMM: 175-315/315.0
RTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGnGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHE
|.. |.||  ||| ||||.. |....|. |.  ....  |...|||||| ||||  |..|..| .|.  . ||.. ||. .|.|| .|||. ||| |...
revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyd

AVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
|.|| ..|||| | .|   .| . .  |.| |  . ||..||
alletfvcgdtsiaqdlylqrydsllapspdtgstllqeqfe
DSPc_SM00195 406-511 3.6e-36 120.2 In-house 156-260 (263) alignment 
Range on Protein: 406-511
Range on HMM: 156-260/263.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAgNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|.|...||.|..|||.|||. . .||.... |..|...  .||..|||||| ||||.....|.||.. .. ...|||. ....|..||.|||| |||.|.
etrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

HEAVLE
.||.||
yeaile
PTPc_SM00194 406-511 3.6e-36 120.2 In-house 156-260 (263) alignment 
Range on Protein: 406-511
Range on HMM: 156-260/263.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAgNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|.|...||.|..|||.|||. . .||.... |..|...  .||..|||||| ||||.....|.||.. .. ...|||. ....|..||.|||| |||.|.
etrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

HEAVLE
.||.||
yeaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 536-753 3.7e-36 119.3 In-house 68-272 (515) alignment 
Range on Protein: 536-753
Range on HMM: 68-272/515.0
NPHTDKSPLqQEFEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL--NDKT-CSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELK
||| |        ...   .|.||.|.|....| |||||| .....||.|...|  .||  |. |||   . || || . |     |       |.|.. 
nPhsdyfna.syipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl

YKEEVHEIRQFEVQTWPtwiqSDGVQSQeqcMDAVLQLMdylHkcEIQRSTEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRL
  .... . ||. . ||      ||. .     ..|.|.   .  |.. ...|       |...||..|.   ||........ . ..  ..|||. .. 
kgddsrtvtqfhfteWP....dkGvpkh...tssllkli...k..evkadhgqyt....hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtn

LRLSRPNFVPTLTDYLLCYKLL
.|  || .| |  .| . |  .
irqkrpylvqtqeqyafiygav
0037934 (Phosphotyrosine protein) phosphatases II 555-754 6.1e-36 119.6 In-house 45-239 (243) alignment 
Range on Protein: 555-754
Range on HMM: 45-239/243.0
NaFIATQMPLDSTVLD----FWRLVHDYHISTIIMLNQLN---DKTCSIYWPvntRSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEEVHEIRQFEV
. .||||.||..|| |    |||......|..|.||..|     . |  |||    .||.|.|||  ...|... ..||||.|..   ..........  
r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

QTWPTWIQSDGVQSQEQCMDAVLQLMDYLHkceiqrstEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLnndGaIDVFQNLRLLRLSRPN-FVPTL
  ||     | ...  . .|.| . .. |.              .| |.||||  |.  .|....   .|..|   | .|... ..|||  ||.  |.|.
lpwpdhgvPdspedlldfldevrefieell........sllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtp

TDYLLCYKLLT
  |  .|..| 
sqyrflyeall
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 549-754 7.7e-36 118.4 In-house 85-280 (290) alignment 
Range on Protein: 549-754
Range on HMM: 85-280/290.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN---DKTCSIYWPVNTRSVtFGPFTVGHKGSENMNRVKVRTLELKYKEE---VHEIRQF
.||..|...|||| |. .|. |||.|. . ... |.|| . .    ..|  ||| .  .  .|.|..     |..|.   |.||.| |..    ... |.
kgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqy

EVQTWPtwiqSDGVQSQEQCMDAVLQLMdylhkCEiqrstEQSRPGdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
....|.    |.|   ..| .  |.. |      .      | ..|   .|.|||  ..  |.|||.... ... . .| ||||| |. .|  .|. | |
qitnwd....stgkvtnpqtillvieem.....yk.....tqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqt

LTDYLLCYKLLT
   | . .... 
vqqyqgifqivl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 404-532 1.2e-35 117.7 In-house 128-255 (392) alignment 
Range on Protein: 404-532
Range on HMM: 128-255/392.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKaGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYA
| . ||  |.|.  ||||.|||..  .||.|..|.    .    ||..||||| |||||.|..||..  ||..  .|.| |.  .|..|| |||| ||||
gddartvaqfhftewPdkdvpkhtssllkfikevkadfGq.ythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqya

FVHEAVLEGLLCGDTLILEDDITERVEQI
|.. |||| ||  .|||    .|......
fiygavledllwrntlipvvhftdhlqdl
subfamily_CG7180_pd Subfamily CG7180 548-760 3.2e-35 116.2 In-house 78-292 (296) alignment 
Range on Protein: 548-760
Range on HMM: 78-292/296.0
FEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK--TCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYK----EEVHEIRQ
 ... ||...| |..| ..|| .|||||.| .||....| .  |    .  ||| ..    .|.. |    ....  .| ||. |. |     | ..  .
vdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvk

FEVQTWpTWIQSDGVQSQEQCMDAVLQLMDYLHKCEIQRSTEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVP
 |. .  . .|    ......      |.. ... .. |   . .|  | |..|..  |   |||....  .||...... .|||. .. || |||. | 
aetRiv.klfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg.PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLve

TLTDYLLCYKLLTHHhTLC
. ..|  .| .| ..  ||
nveeYkyiYdvllea.vlc
PTPc_DSPc_SM00012 409-511 4.7e-35 115.3 In-house 1-105 (105) alignment 
Range on Protein: 409-511
Range on HMM: 1-105/105.0
TLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAG-NGPLLVHCSAGAGRTGVIIAVDSILREAKRS-DQIDIFSFINSMRNNRPQMVQTPEQYAFVH
|.|.||| ||||.|||. . ..|.....|.....|.. ..|..||||||.||||...|.| .|.  ... ...||| .....|. ||.|||| ||| |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAVLE
.|.||
ralle
Y_phosphatase Protein-tyrosine phosphatase 406-511 5e-35 116.4 Pfam-A 131-235 (235) alignment 
Range on Protein: 406-511
Range on HMM: 131-235/235.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQeKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|.|..||.||..|||.|||. . ..|..|..|..|. .| .||..||||||.||||...|.| .|..... ...|........|..||.|||. |||.|.
ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

HEAVLE
..|.||
ykaile
Y_phosphatase Protein-tyrosine phosphatase 406-511 5e-35 116.4 In-house 131-235 (235) alignment 
Range on Protein: 406-511
Range on HMM: 131-235/235.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQeKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|.|..||.||..|||.|||. . ..|..|..|..|. .| .||..||||||.||||...|.| .|..... ...|........|..||.|||. |||.|.
ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

HEAVLE
..|.||
ykaile
subfamily_PTPRG_pd Subfamily PTPRG 549-755 5.4e-35 115.6 In-house 85-285 (563) alignment 
Range on Protein: 549-755
Range on HMM: 85-285/563.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENMNRVKVRTLELKY-----K---EEVH
.|| |..|||||| || .|. ||||.. . . ..|.|. .|..   . | .|||    |.|.| ..|  . .| .    |||| .|      |   ....
dGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdtek

EIRQFEVQTWPTWIQSDgvqSQEQCMDAVLQLmdylhkceiqrstEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRP
..||..  .||     .   ..   .  | .              ..... .  ||.||| .|. ..|... .   |.|.... |..||. |. .|. |.
lvrqyhytkWPdhgvPe...hslpvLifvkks.............saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRn

NFVPTLTDYLLCYKLLTH
. | |  .|.  .. |  
flvqteEqYiflhdalle
subfamily_PTPRB_pd Subfamily PTPRB 549-754 7.4e-35 115.4 In-house 88-282 (293) alignment 
Range on Protein: 549-754
Range on HMM: 88-282/293.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQ
.||. .. ||||| || .|| ||||.|.. . |.|.|| || .|    |  ||| ....|..|  .|  . .|...   .|.|... ..| ...||.. .
pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhft

TWPTWiqsdGVQSQEQCMdavLQLMDYLHKcEIQRSTEQsRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTD
.|| .    || .. . .   |...  ... .|...... |     ||.||| .|.  .|.| .. . |......  .|.|  .  || .| ..| | ..
sWpdh....gvPektktl...ldfvrtvre.aiektask.r.....PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YLLCYKLLT
|.  .. . 
Yifihqcvl
subfamily_Ptp69D_pd Subfamily Ptp69D 549-766 1e-34 115.1 In-house 85-295 (307) alignment 
Range on Protein: 549-766
Range on HMM: 85-295/307.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE-------EVHE
.|| .|. ||| | |...|. ||||.. . .. .|.|| .|..   | |. |||..   | .|   |    .|...    |.|..  |.       . ..
kgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrk

IRQFEVQTWPtwiqsDGVqsQEQCMDAVLQLMDYLHKCEIQRsteqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPN
. |.. ..|.     |      ..  ..|.|.. ... . .            ||.|||  | ..||.| ..   |.||...  .|.|.  . ||  |. 
vvqyhytgWk.....Dsk..vPevargllklieqvrelykln.........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnl

FVPTLTDYLLCYKLLTHHHTLCRSEEEL
.|  |  |  .|. |  ...   ..|..
lvqsleqYvflyralldyssygdtdedv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 406-549 1.6e-34 114.5 In-house 176-324 (325) alignment 
Range on Protein: 406-549
Range on HMM: 176-324/325.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEK-----AGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPE
|.|..||...|.|.| ||.|.   .. ..| |.. .|.      . .|.||||||| ||||| |.. |.| .     ..||| |.. .|..||.||.| .
etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

QYAFVHEAVLEGLLCGDTLILEDDITERVEQIQWPNPHTDKSPLQQEFE
|| ...||. | ...|.| .    .  ..  .|  || |.|  ...|||
qyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 406-510 1.6e-34 114.3 In-house 173-276 (288) alignment 
Range on Protein: 406-510
Range on HMM: 173-276/288.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAgNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
. ....||.|..|||.|||. . |.|.... |. ....   ||..|||||| ||||. ||.| .. . ...|.||...... .|..|...||| .|| |.
teleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

HEAVL
.|..|
yevll
subfamily_PTPRG_pd Subfamily PTPRG 407-527 6.3e-34 112.1 In-house 182-301 (563) alignment 
Range on Protein: 407-527
Range on HMM: 182-301/563.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVnESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
 .. .||||  |||.|||... |||....   .  .||  ||..||||||.||||. |..|..|.. .. .....| |.  .| .|. .||| ||| |.|
eklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflh

EAVLEGLLCGDTLILEDDITE
.|.|| .. ..| .|.... |
dalleaiasketellaeqvee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 549-763 6.7e-34 112.6 In-house 98-297 (319) alignment 
Range on Protein: 549-763
Range on HMM: 98-297/319.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNqlnDKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEEVHEIRQFEVQ
.|| .|. .||.| ||| |. ||||.. .|..|||..|     . || ||| ..  .. . | |  .  |. .   || .||     .... .|.||  .
tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhfl

TWPTWIQSDgvqsqeqcmdAVLQLMDYLHKCEIQRSTEQSRPgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTD
 ||   . |             .||  ..| .  .| |. |     .|.||| .|.  .||. ..   |......  .||.. .| ||  |...|  |..
GwpdvGvpd..........ypsdlmrlvkkvrhltskenhra....nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvq

YLLCYKLLTHHHTLCRSE
| ..|  |  .| . .|.
ykfiysalleehlfghsd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 549-763 7.2e-34 112.6 In-house 62-261 (284) alignment 
Range on Protein: 549-763
Range on HMM: 62-261/284.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNqlnDKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEEVHEIRQFEVQ
.|| .|. .|||| ||| |. ||||.. .|..|||..|    .. || ||| ..  .. . | |  .  |. .   || .||     .... .||||  .
tGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhfl

TWPTWIQSDgvqsqeqcmdAVLQLMDYLHKCEIQRSTEQSRPgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTD
 ||   . |             .||  ..| .  .| |. |     .|.||| .|.  .||. ..   |......  .||.. .| ||  |...|  |..
gwpdvgvpd..........ypsdlmrlvkkvrhltskenhra....nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvq

YLLCYKLLTHHHTLCRSE
| ..|  |  .| . .|.
ykfiysalleehlfghsd
0041856 (Phosphotyrosine protein) phosphatases II 366-518 1.1e-33 111.7 In-house 1-176 (182) alignment 
Range on Protein: 366-518
Range on HMM: 1-176/182.0
NKVKNRYRNILAYDHSRvmleevkgvpDSDYINASYINGIESR--------------------------------------------TLKQYHYQGWPDK
|. ||||..|| |||||          |.|||||... |                                                .  ||.| .||| 
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDh

GVPKfAGPVLKMIQDVNEsqekaGNGPLLVHCSAGAGRTGVIIAVDSILREakrsdQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCGDT
|||     .|..|..|.|      .|| ||||||| ||||...| . ...      ...... .. .|. ||.||.||.|| |.. |.|| ||...|
gvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 549-755 2.5e-33 110.0 In-house 79-291 (301) alignment 
Range on Protein: 549-755
Range on HMM: 79-291/301.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVR-----------------T
.|||.|..|||.| |...|. |||||. ... ..|.|. .|...    |  |||  ...| .||||||  . . ..    .|                 .
dgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierk

LELKYKEEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdAVLQLMDYLhkceIQRsteQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
.. | . . ... |..|  ||.    |||  . .    ||| .|      |.|   | ..| | |..|||  ..  |||.|.|   |||   .| .||||
fkvksdksswdvlqlqvtdWpq....dGvvrepr...tvLqviddv....ihr...qqkiggg.pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfq

NLRLLRLSRPNFVPTLTDYLLCYKLLTH
  . .| |.|  | ||  |   |. .. 
vtkavrrskpgaVtTLeqytsiydvidm
subfamily_Ptp69D_pd Subfamily Ptp69D 407-531 5e-33 109.5 In-house 181-304 (307) alignment 
Range on Protein: 407-531
Range on HMM: 181-304/307.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAgNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
|| . ||||.||.|  ||. |  .||.|. |.| ...  ..|..||||||.||.|...|.||.| . |  |..||| ..  .|..|. .||  ||| |..
srkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfly

EAVLEGLLCGDTLILEDDITERVEQ
 |.|.    ||| .  ||. ...|.
ralldyssygdtdedvddledaier
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 551-760 7.3e-33 108.7 In-house 71-268 (283) alignment 
Range on Protein: 551-760
Range on HMM: 71-268/283.0
YSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELKYK---EEVHEIRQFEV
| ... .|..| ||| || |||..|.| .|..|.|| .| .   . || ||| .  |. .|.|||  .     |   .. | |...   ..   .  . |
ykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqv

QTWptwiqsdgvqsQEQCMDAVLQLMDYLHKCeiqRsTEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLT
. |            |   .|..  .  . |    . . | .  .| ||.||| .||  ..||....  ....  .  .|||. .. .|  |.  | || 
idW...........leygeqaiinslvkfnkv...i.slqteskkg.PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtld

DYLLCYKLLThHHTLC
 | | ..|    ..||
qyklvhelvl.eqalc
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 549-752 8.3e-33 108.6 In-house 80-273 (287) alignment 
Range on Protein: 549-752
Range on HMM: 80-273/287.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPvNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE---EVHEIRQF
.||..|.|||... |. .|. .||.|..| ....|.|| |...   . |  ||| ...||..|....     | .. . .|.||.| |.   . ....|.
dgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp.eeksvvlGeyniellneevnagyierklevknknkagdkqqvkqy

EVQTWPtwiqSDGVQSQEQcmdAVLQLMDylhkceiQRSTEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
.. .|.    | |  .. |   ..| ...       ..  .| ..|.. .|.|||  ..  |..|| .   ... ...|.||||| |.  |  .|. | |
qitnWd....stgkvtepq...tillvie.......emyktqrkrgnt.sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqt

LTDYLLCYKL
 . |   ...
veqykfindi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 550-757 9.7e-33 108.4 In-house 67-268 (274) alignment 
Range on Protein: 550-757
Range on HMM: 67-268/274.0
GYS-KKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNTRS---VTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQF
||. ...|..||| || .|| ||||...  ... |.|| .|..   . |. |.| ..      ..| . .  ..  . |  .||.| ||| |. ...  .
GydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhy

EVQTWPTWIQSDGVQSQEQCMDAVlqlmdylhkceiqRSTEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
    ||   . | ...  . .. |             .......     |..||| .||   |.| .. ... ||.... .||..    ||| |   | |
wytdWPdhksPddantlldlvlev.............eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt

LTDYLLCYKLLTHHH
   | | .. |....
seqyelihralclyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 407-526 1.3e-32 108.4 In-house 184-304 (319) alignment 
Range on Protein: 407-526
Range on HMM: 184-304/319.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQE-KAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
 | ..|.|..||||.|||... ....... |.  .. . .. ...||||||.||||| |..| .|   |. .|.|.. |.. .|..|...||   || |.
irkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

HEAVLEGLLCGDTLILEDDIT
. |.||  | | . .   |. 
ysalleehlfghsdvampdfp
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 407-527 4.1e-32 106.8 In-house 148-269 (284) alignment 
Range on Protein: 407-527
Range on HMM: 148-269/284.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQE-KAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
 |...|.|..||||.|||... ....... |.  .. . .. ...||||||.||||| |..| .|   |. .|.|.. |.. .|..|...||   || |.
irkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

HEAVLEGLLCGDTLILEDDITE
. |.||  | | . .   |.  
ysalleehlfghsdvalpdfpa
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 405-511 7e-32 105.5 In-house 133-238 (239) alignment 
Range on Protein: 405-511
Range on HMM: 133-238/239.0
IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNEsQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAF
 | | . |||.  |||||||..|  || . . . . .   |  | ..||||| |||| .. .|..||.||.   .||| .....|..||.|||| ||| |
teeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvf

VHEAVLE
.| ||||
ihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 405-511 1.1e-31 104.8 In-house 134-239 (239) alignment 
Range on Protein: 405-511
Range on HMM: 134-239/239.0
IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNEsQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAF
 | | . |||.  |||||||..|  || . . . . .   |  | ..||||| |||| .. .|..||.||.   .||| .....|..||.|||| ||| |
teeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvf

VHEAVLE
.| ||||
ihlavle
subfamily_PTPN12_pd Subfamily PTPN12 549-754 1.8e-31 104.1 In-house 77-274 (290) alignment 
Range on Protein: 549-754
Range on HMM: 77-274/290.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQ---LNDKTCSIYWPVN-TRSVTFGPFTVGHKGSENMN-RVKVRTLELKYKEEVHEIRQFE
.| ..| ..||.| ||  |. ||||.. ..... ..|. .   |. | |  ||| .  ....||.|.|  .  ....    .|||... ..| ....||.
kgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfh

VQTWPtwiqSDGVQSQeqcMDAVLQLMDYLHKCEIqrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNND---GAIDVFQNLRLLRLSRPNFV
 . ||      || |.   .. .|.|.. ... .           .  |..||| .|.   |. ...    |.|...     .|||. .. ||  |.  |
YtaWP....DhgvPss...aksllelielvrelqe.........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalv

PTLTDYLLCYKLLT
 |   | | || ..
qtkeqyelvykava
subfamily_PTPN6_pd Subfamily PTPN6 406-510 4.3e-31 103.0 In-house 184-294 (306) alignment 
Range on Protein: 406-510
Range on HMM: 184-294/306.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAG---NGPLLVHCSAGAGRTGVIIAVDSILREAKRS---DQIDIFSFINSMRNNRPQMVQTP
|.|.. |||.. |||.||||  | ||....|||. ||.     .||..|||||| |||| .| .| .|.  ...    .||| ....|.|. | ..||| 
eerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte

EQYAFVHEAVL
.|| ||..|. 
qqykfvykaik
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 407-525 1.7e-30 100.8 In-house 173-291 (439) alignment 
Range on Protein: 407-525
Range on HMM: 173-291/439.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
 ||. |.||  |||| ||  |  ||.... .| ...|   ||..|||||| |||| |||.|  | . |  ...||   .. .|..| ||||.  || |..
ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiy

EAVLEGLLCGDTLILEDDI
.|||| .  ||. .. |..
navledivyGdiavtidef
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 553-756 4.3e-30 99.6 In-house 62-263 (270) alignment 
Range on Protein: 553-756
Range on HMM: 62-263/270.0
KKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRS---VTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQT
.|...||.. ||..|. .|||.. . . ..|.|. .|..|    |. ||| .. .   ...|  .|    .|...   .. |.|..| | ...  |  .|
ekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwynt

WPtwiqSDGVQSQEQCMDAVLQLMDYLHKceIQRSTEQSRPGDgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDY
||     .|| ..|.      ||.  |..  ..||... . ..  |.||||  |.. .|.. ..  ... |.... .|| . .. ||  |...| .   |
Wp....dhgvpreedsslstdqllkmlra..vrrsekeldkae..PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

LLCYKLLTHH
 . || ....
eflykavvey
subfamily_PTPN6_pd Subfamily PTPN6 546-758 5.5e-30 99.4 In-house 91-298 (306) alignment 
Range on Protein: 546-758
Range on HMM: 91-298/306.0
QEFEGYSkkNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLEL---KYKEEVHEI
.|..| .  ...||||  |..|| ||||.| . .   |.|. . ...    |. ||| .... ..|  .| .  ...... ..|.| .   | |.| .|.
kevkgsd..ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerev

RQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDylhkcEIQRSTEQSRPGDGPPILVHCLSGIEESGVFCTV---MNCLEQLNNDGAIDVFQNLRLLRLSR
.|.. ..||      ||... .   |||....     ...| .|...  .  ||.||| .||   | |  .   .. .|.  .|  ||. .  ...|  |
fqyhfksWP....dhgvpkdpg...avLdfle.....dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqr

PNFVPTLTDYLLCYKLLTHHHT
  .| | . | . || ....  
sglvqteqqykfvykaikkyie
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 407-510 7.8e-30 98.8 In-house 151-261 (270) alignment 
Range on Protein: 407-510
Range on HMM: 151-261/270.0
SRTLKQYHYQGWPDKGVPKFAG------PVLKMIQDVNESQEKAGNG-PLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTP
.| |  ..|. |||.|||. ..       .|||...| .|...  .. ||||||||| ||||..||.| ..|  ... ..|. . |. .|..|...||.|
errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhp

EQYAFVHEAVL
|||.|...||.
eqyeflykavv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 405-512 8.2e-30 98.9 In-house 167-275 (281) alignment 
Range on Protein: 405-512
Range on HMM: 167-275/281.0
IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRS-DQIDIFSFINSMRNNRPQMVQTPEQYA
 |.|...| .|. |||.|||. .  .|.  ..|.. .||  . ||..||||| ||||. ||.| ........  ..|.   ....|..|  ||||  ||.
getreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqye

FVHEAVLEG
||. |||. 
fvykavlda
0036282 (Phosphotyrosine protein) phosphatases II 394-507 2.3e-29 97.7 In-house 2-164 (174) alignment 
Range on Protein: 394-507
Range on HMM: 2-164/174.0
SDYINASYING---------------------------------------------------IESRTLKQYHYQGWPDKGVPKFAGpVLKMIQDVNESQE
|||||||....                                                    ..|.  ||.| .||| ||| ..  .|.... |.| ..
sdyinaspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveeals

KAGNGPLLVHCSAGAGRTGVIIAVDSILREAKrSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHE
. ..||.||||||| ||||...| . .||  . .. .|..... ..|. ||.|||||.|| |...
edpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 408-518 2.7e-29 97.0 In-house 173-283 (287) alignment 
Range on Protein: 408-518
Range on HMM: 173-283/287.0
RTLKQYHYQGWPDKG-VPKFAGpVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
...|||..  |...| |....  .| .|.. . .| | ||....||||.. ||... .|..  ....|.   ||.|. ..|.|  .|..||| ||| |. 
qqvkqyqitnWdstgkvtepqt.illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfin

EAVLEGLLCGDT
..||| | ...|
divleyldsfet
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 406-510 6.6e-29 95.8 In-house 159-265 (274) alignment 
Range on Protein: 406-510
Range on HMM: 159-265/274.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAG--NGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYA
..|..| | |  |||. .|. | ..|.....|.||.|..    .| .|||||| ||||. ||..  .|. ...  .|... .  .| .|  |||| ||| 
rersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqye

FVHEAVL
..|.|. 
lihralc
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 549-757 1.7e-28 94.4 In-house 66-259 (267) alignment 
Range on Protein: 549-757
Range on HMM: 66-259/267.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKTCSIYWPVN-TRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEE-VHEIRQFEVQT
||| .|||||.|| ||. |. ||. ..||.....|..| .        .|| .  ..  .  .|| |   .. |  .. |||||.|.|  |..  .  . 
egyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykk

WPtwiqsdgVQSQEQCmdAVLQLMDYLHKCEIQRsteqsrpGdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDY
|        ......    .  |.  | | ...        | ..|..|.|  |.  || | ..   ||.. ..|  |.|. || .|  |. .| |.  |
wn.......intnnkp..ylkplfgilaknqlen.......g.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery

LLCYKLLTHHH
. ...||... 
iyihellaeya
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 407-511 2.6e-28 93.9 In-house 132-237 (237) alignment 
Range on Protein: 407-511
Range on HMM: 132-237/237.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQD-VNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
 | ..||..  |||.|||. .  .|.. .. .|.|.  .  || ..||||| ||||... .|..||.||    .||. .. |. ..|| ..|| .|| |.
vrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfi

HEAVLE
|...||
hqtile
subfamily_PTPN14_pd Subfamily PTPN14 552-755 4e-28 93.3 In-house 90-294 (300) alignment 
Range on Protein: 552-755
Range on HMM: 90-294/300.0
SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL--ND-KTCSIYWPVN---TRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQ
.|.  .|..| ||. || |||..| . ... |.|| .   .  . .  |.| .    ..|.|| | |  | ||. ..|  ..|.||.    .|   . .|
gkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlq

tWPTWiqsdgvqSQEQCMDAVLQLMDYLHKCE-IQRSTEQSRP--GDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
 .  |       ..... . | . ..||.. . ..| |.....     ||.||||. |.  .||  ..   .. |...  ||. . |. ||  |  .|.|
.ytDW.......pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt

LTDYLLCYKLLTH
|. |   ||.| .
laqYkfvYkvlik
0051429 (Phosphotyrosine protein) phosphatases II 401-513 5.3e-28 93.8 In-house 11-225 (272) alignment 
Range on Protein: 401-513
Range on HMM: 11-225/272.0
YI--------------------------------------------------------------------------------------------------
..                                                                                                  
dvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrelll

----NGIESRTLKQYHYQGWPDKGVPKFAgpVLKMIQDVNEsqekagNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQID--------IFSFINSMRN
    .  |.|.. ..||..||| |||. |  .|.... ...      .||.||||||| .|||...|.. .|.   ... .|        .. ... .| 
tlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelra

NRPQMVQTPEQYAFVHEAVLEGL
 ||..|||.|||.|..||.|| |
qrpgavqteeqylflyeallell
0043147 (Phosphotyrosine protein) phosphatases II 392-507 7.8e-28 92.7 In-house 3-155 (172) alignment 
Range on Protein: 392-507
Range on HMM: 3-155/172.0
PDSDYINASYIN--------------------------------------------GIESRTLKQYHYQGWPDKGVPkFAGPVLKMIQDVNESQEKAGNG
..||||||||..                                              ..|.  ||.| .||| |||  .  .|.... ..| . .  .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspgg

PLLVHCSAGAGRTGVIIAVDSILreakrsDQIDIFSFINSMRNNRPQMVQTPEQYAFVHE
| ||||||| ||||...| . .|       .....  .. .|. ||..||.|.|| |...
pvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyy
subfamily_PTPN23_pd Subfamily PTPN23 556-754 2.4e-27 90.5 In-house 84-277 (288) alignment 
Range on Protein: 556-754
Range on HMM: 84-277/288.0
AFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL---NDKTCSIYWPVNT-RSVTFGPFTVGHKGSENMNRVKVRTLELKYKE--EVHEIRQFEVQTWPT
 ||||| ||.||. |||..|.. . |.|.|| .    ... .. ||| .. ..|.||...|  |  .... .  |.|.|. ..  .|....  ....|| 
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

WiqsdGVQSQEqcmDAVLQLMDYLHKC-E-IQRSTEQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNN-DGAIDVFQNLRLLRLSRPNFVPTLTDY
     || .     . .||..|  ... |  || ...       |..|||..|.. .|||. |.  ...|.. .| .|. | .. ||  | . | . . .
l....GvPasP...etllqfldevesayeavqrkskt.......PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql

LLCYKLLT
  .|.   
kfsyeavl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 408-513 3.3e-27 90.1 In-house 178-283 (290) alignment 
Range on Protein: 408-513
Range on HMM: 178-283/290.0
RTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHE
....||. . |...|  .    .| .|. ... | | ||....||||.. ||..| .|..  .  .|   .||.|. ..|.|  .|..||| .|| ....
qsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifq

AVLEGL
 ||. |
ivltyl
subfamily_PTPN13_pd Subfamily PTPN13 406-513 5.9e-27 89.6 In-house 164-269 (273) alignment 
Range on Protein: 406-513
Range on HMM: 164-269/273.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkaGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
||| . . ..  ||| |||. | ..|.... |.. |.   .||..|||||| ||.|..|..| .|   .|  ..|.   ....|. |  .||| .|| ||
esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv

HEAVLEGL
..|.|| |
ykailevl
0051429 (Phosphotyrosine protein) phosphatases II 551-755 8.8e-27 89.8 In-house 18-223 (272) alignment 
Range on Protein: 551-755
Range on HMM: 18-223/272.0
YSKKNAFIATQMPLDSTVLDFWRLvHDYHISTIIMLNQLN---DKTCSIYWP-----------VNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV
. |.........||. |. ||||| ....|.||..| ...      |. |||             . ....| ..| .   |... . .|.|.|...   
vvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

HEIRQFEVQTWPTWIQSDGVQsqeqcmDAVLQLMDYLHKceiqrsteqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAID--------VFQN
.|.|.. . ..  |.     |      .|.|.|...|..              | |.|||| .|.  .|... .  .|.... .  .|        ... 
gearevmhlhytdwpdhgvpq......eallellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

LRLLRLSRPNFVPTLTDYLLCYKLLTH
.. ||  ||..|.| . || .|. | .
veelraqrpgavqteeqylflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 412-523 1.2e-26 88.2 In-house 166-276 (283) alignment 
Range on Protein: 412-523
Range on HMM: 166-276/283.0
QYHYQGWPDKGVPKFAGPVLKmIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLE
 | ...| . |       ..| .  |   | .  .||..||||.| |||.| ||. . . .|. .  .|.|. .. ||..|. .||| .|| .|||.|||
hyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

GLLCGDTLILED
  ||||| |   
qalcgdtqiaav
subfamily_PTPN3_pd Subfamily PTPN3 545-749 2.7e-26 87.1 In-house 74-268 (280) alignment 
Range on Protein: 545-749
Range on HMM: 74-268/280.0
QQEFEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE--EVHEI
. | .. .  | .|||| ||..|. |||..|.. ..|.|.|| .| ..    |  ||| .. ....| |.|  . ... . . .| | || ||  | ..|
nmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerki

RQFEVQTWPTwiqsDGVQSQEQcmdAVLQLMDYLHKCEiqrsteqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNF
 |.    ||      || ....    .|.... ..|.           |.  |..||| .||. .||. ..  .|  ...  .. . . .| .|  | ..
lqlqylaWpd....hgvPddsa...dflefvervrklr.........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqraml

VPTLTDYLL-C
|.| . | . |
vqtasqykfvC
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 549-754 3.9e-26 86.8 In-house 78-273 (281) alignment 
Range on Protein: 549-754
Range on HMM: 78-273/281.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN---DKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLEL-KYKEEVHEIRQFEV
.||......|||| |. ... .||..| ....|.|.|. .        |  ||| .. ....| .|| .. .|. ..   |...| . . |  |..|.. 
pgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlay

QTWPtwiqSDGVQSQEQcmdavlQLMDYlhKCEIQRSTEQSRPgdgPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQNLRLLRLSRPNFVPTL
..||      || .. .      .|...  . |... ||...     |...|| .|.  .|.. ..   .......   .|| . .. || .|  .| |.
taWP....dhGvPattk......ellef..rkevlkltekktk...aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

TDYLLCYKLLT
. |   || . 
vqyefvykavl
subfamily_PTPN3_pd Subfamily PTPN3 406-511 6.1e-26 86.0 In-house 169-273 (280) alignment 
Range on Protein: 406-511
Range on HMM: 169-273/280.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
|.|.. |  |  |||.|||. .  .|.... |.. .. . . |..|||||| |||||.|...  |    ..... .   .  ||. |  .|||..|| ||
eerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv

HEAVLE
 ||.|.
Ceailk
0049772 (Phosphotyrosine protein) phosphatases II 359-512 1e-25 86.6 In-house 39-279 (314) alignment 
Range on Protein: 359-512
Range on HMM: 39-279/314.0
QIASLPNNKVKNRYRNILAYDhSRVMLeEVKGVPDSDYINASYINGIeSRTL------------------------------------------------
 .|.|. |. |||| .|| .| .||.|    .| .||||||||..|.  . .                                                
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

---------------------------------------------KQYHYQGWPDKGVPkFAGPVLKMIQDVNESqekAGNGPLLVHCSAGAGRTGVIIA
                                              .|..  .|| ..|     ...... ..|      .||.||||.|| ||||. ..
lsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvv

VDSILREAkrsdQIDIFSFINSMRNNRP-----QMVQTPEQYAFVHEAVLEG
.. ...      ....   .. .|. ||      .....||| |..||.|| 
aaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_PTPRD_pd Subfamily PTPRD 322-406 5.8e-25 82.9 In-house 2-88 (564) alignment 
Range on Protein: 322-406
Range on HMM: 2-88/564.0
QRPIIVADFADYVQNNR--RSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
..|| ||.....|.. .  ..  || |.  . .| . . . |. | || |||| ||.|||||||.|..|.|...|||||||.|.| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 406-517 7.1e-25 82.3 In-house 186-297 (301) alignment 
Range on Protein: 406-517
Range on HMM: 186-297/301.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
.|... |..   ||. || .    ||. |.||   | | | ||..||||.. .|.|| ..|.  |  .|.   .|.|  ....| ..| .|.| ||| ..
sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsi

HEAVLEGLLCGD
.... . | . .
ydvidmylqlns
subfamily_PTPN13_pd Subfamily PTPN13 555-753 7.2e-25 82.8 In-house 77-265 (273) alignment 
Range on Protein: 555-753
Range on HMM: 77-265/273.0
NAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSV-TF-GPFTVGHKGSENMNRVKVRTLELKYK--EEVHEIRQFEVQTW
  .||.| ||  || |||..| . . . |.|. .  .|    |  |||.....  .  . ..|   . ....  .||.|..| .  .|..|. ...  .|
yeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkw

PTwiqsDGVQSQEQCMdavLQLMDYLHKceIQRSTEqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYL
|      || |. . .   ||.. .. .  .|...         ||.||| .||  ||.. |.   |. ...|  .|| . .| ||  |   | |   |.
Pd....hgvPssaael...lqfvaevrr..lqtdag........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyi

LCYKLL
..|| .
fvykai
0041856 (Phosphotyrosine protein) phosphatases II 549-755 8.4e-25 82.8 In-house 28-169 (182) alignment 
Range on Protein: 549-755
Range on HMM: 28-169/182.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNqlndktCSIYWPvntrsvtfgpftvghkgsenmnrvkvrtlelkyKEEVHEIRQFEVQTWP
 |. . . ||||| ||.||| ||.|......|.||..|.      .  |||                                 ... ... |.    ||
lgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp.................................ellerlgiqylylpwp

TWIQSDgvqsqeqcMDAVLQLMDYLHKceiqrsteqsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQlnndGaIDVFQNLRLLRLSRPNFVPTLTDYLL
 .   |        .| .|....  ..             .| |.||||  |.  .|...    ....    | ..... ..|.|  ||. | |.  | .
Dhgvpd........ldelldfieevle.............eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyff

CYKLLTH
.. .| .
lqlalle
0048076 (Phosphotyrosine protein) phosphatases II 396-510 1e-24 82.2 In-house 33-140 (145) alignment 
Range on Protein: 396-510
Range on HMM: 33-140/145.0
YINASYINGIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKagNGPLLVHCSAGAGRTGVIIAVDSILReakrsDQIDIFSFINSMRNNRPQM
 .| ..    ..|.  ||.| .||| ||| ..  .|.... ..| ...  .|| ||||||| ||||...| . .|.      ...... .. .|. ||..
vlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga

VQTPEQYAFVHEAVL
|..|.|. |..|..|
vpnpgqlrflyefel
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 550-754 1.3e-24 81.5 In-house 75-274 (287) alignment 
Range on Protein: 550-754
Range on HMM: 75-274/287.0
GYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIML-NQLND--KTCSIYWPVNTRSVTFGPFTVGHKGSENMN-RVKVRTLELKYKE--EVHEIRQFE
.| ...||||.| |. .|| ||||.| . . ...|..  ....  . |  ||| . . .  | ..|     ....    ||.| |   |  | . ..|..
sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqld

VQTWPtwiqsDGVQSQEqCMDAVLQLMDYLHKCEIQRSTEQSrpgdGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
. .||     |.| .   ..  .   .|  .. |..|....     || ..||.  ||  ||.. ... ....|.. | .|| . .  ||  |  .| . 
llswP.....dkvlaPt.avglirfvldvkqhielardasev....GP.lvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

TDYLLCYKLLT
  . | |. |.
vqlrllyealv
0049260 (Phosphotyrosine protein) phosphatases II 398-507 1.4e-24 81.9 In-house 55-144 (152) alignment 
Range on Protein: 398-507
Range on HMM: 55-144/152.0
NasyingiesrtlkQYHYQGWPDKGVPKFAGPVLKMIQDVNESqEKAGNGPLLVHCSAGAGRTGVIIAVDSILreakrsDQIDIFSFINSMRNNRPQMVQ
              ||..  ||| |||...  .| ... ...   .  .|| ||||||| ||||...| . .|       ..... ... .|. ||..|.
i.............qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavp

TPEQYAFVHE
.|.|. |..|
npgqlrflye
subfamily_PTPN1_pd Subfamily PTPN1 406-515 3.1e-24 80.2 In-house 160-273 (290) alignment 
Range on Protein: 406-515
Range on HMM: 160-273/290.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQE-KAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQ---IDIFSFINSMRNNRPQMVQTPEQ
|.|.. ..||  ||| |||.  .  ||....| ||   .   || ..||||| ||.| .. ||..| . ...|.   .||   .  .|. |  ..||..|
etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadq

YAFVHEAVLEGLLC
  | . |.|||  .
lrfsylaileGakv
subfamily_PTPRN_pd Subfamily PTPRN 405-511 3.8e-24 79.9 In-house 184-290 (297) alignment 
Range on Protein: 405-511
Range on HMM: 184-290/297.0
IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKaGNGPLLVHCSAGAGRTGVIIAVDSILRE-AKRSDQIDIFSFINSMRNNRPQMVQTPEQYA
 |.||. |.|.  ||..|||  | ..|.. . || |       |..||||.||||||| |..| .|   .|   .||| . .. .|..||..|.| .|. 
setrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe

FVHEAVLE
|.  || |
faltavae
0046846 (Phosphotyrosine protein) phosphatases II 391-511 4.3e-24 80.6 In-house 9-171 (176) alignment 
Range on Protein: 391-511
Range on HMM: 9-171/176.0
VPDSDYINASYINGIES------------------------------------------------RTLKQYHYQGWPDKGVPKFaGPVLKMIQDVNESQE
 .|.|||||..| |                                                   .   ||.. .||| ||| .   .|.... ..| ..
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

KAgnGPLLVHCSAGAGRTGVIIAVDSILReakrSDQIDIFSFINSMRNNRP-QMVQTPEQYAFVHEAVLE
.   || ||||||| ||||...| . . .    . .....  .  .|. || ..||||||| |..|..|.
eg..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefell
0044763 (Phosphotyrosine protein) phosphatases II 378-512 9.9e-24 79.4 In-house 2-170 (178) alignment 
Range on Protein: 378-512
Range on HMM: 2-170/178.0
YDHSRVMLEEVKGVPDSDYINASYING--------------------------------------IESRTL---KQYHYQGWPDKGVPKFAGPVLKMIQD
.|..|| |... |.. |||||||.| .                                      ..        ||.. ..|| |||     .|.... 
ldrtrvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvef

VNESQEkAGNGPLLVHCSAGAGRTGVIIAVDSILREakrsdQIDIFSFINSMRNNRPqMVQTPEQYAFVHEAVLEG
..| ..   .|| ||||||| ||.|...| . ...      ...... |. .|. || .|..|.|. ...|  |. 
ieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 546-751 1.1e-23 78.7 In-house 38-233 (237) alignment 
Range on Protein: 546-751
Range on HMM: 38-233/237.0
QEFEGYSKKnaFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL---NDKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQF
..|.|  ||  .||.| ||.|.  |||..| . . | |.||  |   |.. |  |||   .  ..| .||  |  |..    ||.| | .. ...|.|  
kgfdgtpkk..yiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrli

EVQTWPTWIqSDGVQsqeQCMDAVLQLmdylHKCEIQRSTEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPT
    . .|    ||    |   |.|..     |  |.||   |. |   | ..|| .|.  .|.|  .   | | ..   .|... .  .   ||  . |
hqyqftswp.drgvp...qqtaallrf....rkniinrsphvsesg...pwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt

LTDYLLCYK
  .|.. ..
kdqyvfihq
subfamily_CG7180_pd Subfamily CG7180 405-517 1.8e-23 77.6 In-house 177-294 (296) alignment 
Range on Protein: 405-517
Range on HMM: 177-294/296.0
IESRTLKQYHYQGWPD-KGVPKFAGPVLKMIQDVNESQEKA----GNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTP
.| |..|..... |.  . ||  .  ...... |.  .||.     .||..|..| ||.|.|| .|.|  |  ... ...|.| ..  .|..|||.|.. 
aetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv

EQYAFVHEAVLEGLLCGD
|.| .. . .|| .||. 
eeYkyiYdvlleavlcnk
subfamily_PTPN9_pd Subfamily PTPN9 406-511 2.3e-23 77.7 In-house 171-288 (297) alignment 
Range on Protein: 406-511
Range on HMM: 171-288/297.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKA------------GNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRP
|||..  . . .||| |||. |  .|.... | | | .|             . |..|||||| ||||  |..|  | . .. ...|..  .. .|. | 
esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqra

QMVQTPEQYAFVHEAVLE
 ..||||||.| . ||||
fsiqtpeqyefcylavle
0048179 (Phosphotyrosine protein) phosphatases II 405-507 4.7e-23 76.9 In-house 44-139 (144) alignment 
Range on Protein: 405-507
Range on HMM: 44-139/144.0
IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkaGNGPLLVHCSAGAGRTGVIIAVDSILreakrSDQIDIFSFINSMRNNRPQMVQTPEQYAF
 . |.  ||.. .||| ||| ..  .|.... ..| .|   .|| ||||||| ||||...| . ..       ...... .. .|. ||..|..|.|. |
fleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrf

VHE
..|
Lle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 555-752 1.9e-22 74.5 In-house 76-290 (297) alignment 
Range on Protein: 555-752
Range on HMM: 76-290/297.0
NAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGH--KGSENMNRVKVRTLELKYKEEVHEIRQFEVQTWP
  .| .| ||..|| |||.|| .  . .|.|. .|..     |  |||  .    . | . | .  . |.. .||..  |.| |..|   .|  .  .||
lkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswp

TWIQS----DGVQSQEQCM------DAVLQLMD-YLHKCEIQRSTEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRP
         | |. | |          .| |.. .     .|  . ..      ..|||| .|.  |||    .  |..| ..   ||   |. ||  |.
dhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqra

NFVPTLTDYLLCYKL
  | ||  . |.|..
rlvqtleqfellyda
0036282 (Phosphotyrosine protein) phosphatases II 551-751 1.4e-21 72.4 In-house 13-164 (174) alignment 
Range on Protein: 551-751
Range on HMM: 13-164/174.0
YSKKNAFIATQMPLDstvldFWRLVHDYHISTIIMLNQLNDKT---CSIYWPVntrsvtfgpftvghkgsenmnrvkvrtlelKYKEEVHEIRQFEVQTW
.   . .||.| ||.     ||.......|.|..||.... .    |  |||                               ... ..... |.    |
syitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredlerlgiqylylpw

PTWIQSDGVQsQEQCMDAVLQLMdylhkceiqrsteqSRpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNnDGAIDVFQNLRLLRLSRPNFVPTLTDYL
|     |  .  ......| . .              |. ..| |.||||  |.  .|...  . .| .|   ...|... .| ||| ||. |.|   | 
pDhgvpdlsi.llefvkfveeal..............se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

LCYK
 .|.
flyy
subfamily_PTPN14_pd Subfamily PTPN14 404-511 3.4e-21 70.5 In-house 179-294 (300) alignment 
Range on Protein: 404-511
Range on HMM: 179-294/300.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKM---IQDVNESQE-----KAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQM
  | ||.    |. |||.|||.   . |.    .| | .  .     |  . |.|||||||.|||||.| .| ..   .  ..||| . .. .|. |  .
skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmll

VQTPEQYAFVHEAVLE
|||  || ||......
vqtlaqYkfvYkvlik
0049772 (Phosphotyrosine protein) phosphatases II 550-758 3.8e-21 71.6 In-house 82-281 (314) alignment 
Range on Protein: 550-758
Range on HMM: 82-281/314.0
GYskkNAFIATQMPLDSTVLDF----------WRLV--HDYHISTIIM---------------------LNQLNDKTcsiywpvntrsvtfgpftvGHKG
|.   ..||||| ||. || ||          ||.|   |... .| |                     |..|  ..                   ..  
gf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...................nept

SENMNRVKvrtlelkykeevheirqfEVQTWPTWIQSDGVQS--------QEQCMDAVLQLMDYLHKCeiQrsteqsrpgDGPPILVHCLSGIEESGVFC
 ...   |                  |....| . .  |..         ..   . ...........  .         .| |.|||| .|.  .|.|.
aadlellk..................eelydpelferlgikylripvpDgsaplledfdeflefieea..d.........kggpvlvHCkaGkgRtgtfv

TVMNCLEQLNndgaIDVFQNLRLLRLSRP-----NFVPTLTDYLLCYKLLTHHHT
... .. .|.    ... . |. .|| ||     .|...| .|. ... | ..  
vaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0051082 (Phosphotyrosine protein) phosphatases II 394-510 6.4e-21 70.0 In-house 3-150 (151) alignment 
Range on Protein: 394-510
Range on HMM: 3-150/151.0
SDYINASYINGI-----------------------------------------ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNEsqekAGNGPLLVH
|||||.||. |                                          .......... .||| |.| .   ||.... ...     .|||.|||
sdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld....kkngpvlvH

CSAGAGRTGVIIAVDSILREakrsdqIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVL
|||| ||||...|.. .|.       ..... .. .|  || .||...|. |.. |.|
CsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfall
0049260 (Phosphotyrosine protein) phosphatases II 549-751 7.8e-21 69.8 In-house 3-144 (152) alignment 
Range on Protein: 549-751
Range on HMM: 3-144/152.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevQ
.|| ....||||| |.. |. ||||......|.||.||..| ..    |  |.                                              |
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................q

TWPTWIQSDGVQSQEQCMDAVLQLMDYLhkceiqR----SteqsrpgdgpPILVHCLSGIEESGVFCTVMNCLeqlnndGAIDVFQNLRLLRLSRPNFVP
   ...  .||.. .|... .|.... |      .               |.||||  |.  .|...    .|        ..... ..|.|  ||. ||
ylhlpwpDhgvpdlsqlllflllfiekl......aldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavp

TLTDYLLCYK
.   . ..|.
npgqlrflye
subfamily_PTPN1_pd Subfamily PTPN1 554-743 1.3e-20 68.3 In-house 70-257 (290) alignment 
Range on Protein: 554-743
Range on HMM: 70-257/290.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTR--SVTFG--PFTVGHKGSENMNRVKVRTLELKY--KEEVHEIRQFEV
|  .| || || .||  ||..| . .  ...|||.. .|    |  ||| . .  ....    ..|     |. .  .||.|||.    .| .|| .|  
krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhy

QTWPTWiqsdGVQSQEQcmdavlQLMDYLHKCeiqRSTEQSRPGDGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGA---IDVFQNLRLLRLSRPNFVP
 ||| .    || .  .      .....|.|.   |..    .  ||  ..|| .||  || || |  || .... .    .|. . |  ||  |  .. 
ttwpdf....gvpespa......aflkflfkv...resGslssdvGp.avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

TL
| 
ta
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 321-408 2.1e-20 68.0 In-house 6-93 (297) alignment 
Range on Protein: 321-408
Range on HMM: 6-93/297.0
SQRPIIVADFADYVQNNRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIESR
 .||| ..||| .||.||..  |..|   ||.   ||.  |    |  |.||.||| || |||.|. |   |||||.|||...|.. |
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhr
0043147 (Phosphotyrosine protein) phosphatases II 550-751 2.3e-20 68.5 In-house 15-155 (172) alignment 
Range on Protein: 550-751
Range on HMM: 15-155/172.0
GYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyK----EEVHEIRQFEVQ
.| . . ||||| ||..|. ||||......|..|..|..|                                                 ..... |.   
lyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpellerlgiqylyl

TWPtwiqSDGVQsQEQCMDAVLQLMDY-LHK-CeiqrsteqsrpgdGPPILVHCLSGIEESGVFCTVMNCLeqlnndGAIDVFQNLRLLRLSRPNFVPTL
 ||      ||.   . .. .|...|  |..               | |.||||  |.  .|...    .|        ..... ..|.|  ||. |.. 
pwp....Dhgvp.llellleflefidellalsp.............ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

TDYLLCYK
  | ..|.
sqyrflyy
subfamily_PTPRB_pd Subfamily PTPRB 321-408 6.4e-20 66.4 In-house 3-93 (293) alignment 
Range on Protein: 321-408
Range on HMM: 3-93/293.0
SQRPIIVADFADYVQNNRR--SRAFEDEWSLLPS-GLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIESR
...|| . .|...|.....     | .|.. | . | .|  ..|.|. |. ||||.|||.|||||| |...|. ..||||||.||.| .|.
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp
subfamily_PTPN23_pd Subfamily PTPN23 408-511 8.4e-20 65.7 In-house 171-278 (288) alignment 
Range on Protein: 408-511
Range on HMM: 171-278/288.0
RTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNE---SQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQI-DIFSFINSMRNNRPQMVQTPEQYA
....  ... ||. |||.  . .|.... |..   ....  . ||.|||||| |||||.  | ...|| .. . . ||   .. .|..|  |||. ||. 
ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

FVHEAVLE
|. |||||
fsyeavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 323-407 9.5e-20 65.3 In-house 2-86 (392) alignment 
Range on Protein: 323-407
Range on HMM: 2-86/392.0
RPIIVADFADYVQNNRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
.|| ||.|  .|..||.|  | .|.  ||.    | ..|  . |. ||||.||| || .||.|| .  .|||||.|||||.....
qpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 554-752 1.2e-19 65.1 In-house 93-278 (290) alignment 
Range on Protein: 554-752
Range on HMM: 93-278/290.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGS-ENMNRVKVRTLELKYKEE--VHEIRQFEVQT
|  || || .| .||.|.||.| . ....|.|| .| .     |. |.| .  . .||| .||    . .. .... .|| .. |..   | .. .....
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WPtwiqsDgvQSQEQCMDAVLQLMDYLHKCeiqrsteqsrPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDY
||     |  .|  .   |.|...  | |           .|   |. ||| .||  .| | ..  .|. | .  ..|. .  | || || | |   ..|
wp.....d..ksvalstlallrtlrilrka..........sG...pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqy

LLCYKL
|.  ..
lalvei
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 404-512 1.3e-19 65.0 In-house 182-286 (305) alignment 
Range on Protein: 404-512
Range on HMM: 182-286/305.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESqekagNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIF-SFINSMRNNRPQMVQTPEQY
| ..|  ..||.  |||.|||     .|.....   |      ||. |||||| |||| .. .. || .    ..|.     .. .|..| . .|| .||
gekarkvthyhwidwpdrgvpaadlailellekarps.....kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqy

AFVHEAVLEG
 |||. .|. 
lfvhqvilny
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 413-510 1.3e-19 65.3 In-house 161-256 (267) alignment 
Range on Protein: 413-510
Range on HMM: 161-256/267.0
YHYQGWPDKGVPKfagPVLKMIQD-VNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVL
|.|. |  .   |   | || .   . . | . || ||.|.||.| ||.|  . .|| |. ||. .  ||| |.  .|. |. .|.| |.| ..|| . 
yyykkwnintnnk...pylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 324-406 2.1e-19 64.5 In-house 2-84 (315) alignment 
Range on Protein: 324-406
Range on HMM: 2-84/315.0
PIIVADFADYVQNNRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
|| ||.|  .|..||..  | .|.  ||     . ..|  ..|  ||||.||| .|..||.|| .   |||||||||||....
pipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 323-404 6.8e-19 63.1 In-house 3-86 (319) alignment 
Range on Protein: 323-404
Range on HMM: 3-86/319.0
RPIIVADFADYVQNNRR--SRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
..| |......... .   .. .| |. ||  . ..  . || ..|| ||||.||||||..||.| |..||..|||||||.|.|
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 404-510 8.1e-19 62.5 In-house 164-274 (287) alignment 
Range on Protein: 404-510
Range on HMM: 164-274/287.0
GIESRTLKQYHYQGWPDKGVPKF----AGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTP
. |.| .||...  ||||...      .  ||.. | .. ... .. |||.||...|.||.|...|.  ...  .   ..|.   .  .|. |  .||..
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

EQYAFVHEAVL
 |. .. ||. 
vqlrllyealv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 548-751 9.3e-19 62.2 In-house 84-273 (439) alignment 
Range on Protein: 548-751
Range on HMM: 84-273/439.0
FEGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKTCsiYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV----HEIRQFE
 .|| ... .||||.| . |. |||||| . . .||.|| .| .     ||| ..  | .|  .|      .. .  .| . .  . .     . . || 
ikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfh

VQTWPTwiqsDGVQSQEQcmdavlQLMDYLHKceIQRSTEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTL
  .||       | .|         ..|.|.   |. . ..   |   |..||| .|.  .|   ..  .||||. .  .|.   ...||  | ..| .|
yiawpd....knvpaqas......hvldflra..insandkeeyg...pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal

TDYLLCYK
 .|.. |.
cqyvfiyn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 406-513 1.1e-18 62.3 In-house 174-277 (307) alignment 
Range on Protein: 406-513
Range on HMM: 174-277/307.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkagngPLLVHCSAGAGRTGVIIAVDSILREAK-RSDQIDIFSFINSMRNNRPQMVQTPEQYAF
.|||.... .. |||.|||.     . ... |.  ..     |..|||||| ||.| |.|.  .        .  |.  ... .|..|.  .||  || .
ksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyly

VHEAVLEGL
.|  .|| .
lhrvlleyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 407-515 1.3e-18 62.1 In-house 169-273 (288) alignment 
Range on Protein: 407-515
Range on HMM: 169-273/288.0
SR-TLKQYHYQGWPDKGVPKFAGPVLKMIQDVnESQEKagngPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFV
 .  .|. |.. |.|.|||.   . |.... . .| .|    |..||.|||.|||| .| .  .|. .. .|.. | |.....|..| . .||  || .|
ekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyv

HEAVLEGLLC
|  ||| || 
hrcvleelll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 334-408 5.3e-18 60.3 In-house 20-98 (298) alignment 
Range on Protein: 334-408
Range on HMM: 20-98/298.0
VQNNRRSRAFEDEWSLLPSGLS----QPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIESR
|... .   ...|.  | |. |    . ...|. |.|| |||| .|.|.|.|||.||....  .|||||||.... . |
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgr
0046846 (Phosphotyrosine protein) phosphatases II 555-752 8.5e-18 60.2 In-house 23-168 (176) alignment 
Range on Protein: 555-752
Range on HMM: 23-168/176.0
NAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN---DKTCSIYWPVnT-RSVTfgpftvghkgsenmnrvkvrtlelkykeevheirqfevQTWPTW
...|||| || .|. ||........|.....|...       |  |||.   .                                         | . . 
srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi......................................qylhlp

IQSDGVQSQEQCMDAVLQLMDYLhkceiqrsteqsrpGDGPPILVHCLSGIEESGVFCTVMncleQLNNDGAIDVFQNLRLLRLSRP-NFVPTLTDYLLC
.   || . |...... .. ..|               .| |.||||  ||  .|...        |  .  ..|.. |.|.|  || . |.|   |  .
wpDhgvpdlelllellefireal..............keggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfl

YKL
|. 
yef
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 324-406 9.2e-18 58.6 In-house 1-83 (515) alignment 
Range on Protein: 324-406
Range on HMM: 1-83/515.0
PIIVADFADYVQNNRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
|. .|.|  .|. ||.   | .|.  ||     |  .|    |  ||||.||| || .|| || ..  |.|||.|||||....
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfd
subfamily_PTPRA_pd Subfamily PTPRA 338-406 1e-17 59.0 In-house 29-98 (330) alignment 
Range on Protein: 338-406
Range on HMM: 29-98/330.0
RRSRAFEDEWSLLPSGL-SQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
  .. | .|.  ||.|      ..||  .|| |||. ||| ||.|||.| ...||..|||||||.|.| .
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk
0051082 (Phosphotyrosine protein) phosphatases II 557-752 1.7e-17 58.9 In-house 15-148 (151) alignment 
Range on Protein: 557-752
Range on HMM: 15-148/151.0
FIATQMPLDstvlDFWRLVHDYHISTIIMLNQLN-DKTCSIYWPVNTrsvtfgpftvghkgsenmnrvkvrtlelkykeevHEIRQFEVQTWPTWIqsdg
......||.    ||..|.....|.||..|...   ..|  |.| .                                   .|.... .  ||.      
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................ievlhipildwpdpg....

vqsQEQCMDAVLQLMDYLHKceiqrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQlnndgaIDVFQNLRLLRLSRPNFVPTLTDYLLCYKL
    ... ||||.....| .             .. |.|||| .|.  .|... .. .|..      ..... |. .||.||..| . . .|.... 
...lplsfdavleflellld............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 327-405 1.8e-17 58.4 In-house 4-85 (318) alignment 
Range on Protein: 327-405
Range on HMM: 4-85/318.0
VADFADYVQNNRRS--RAFEDEWSLLPSGLSQPSQI-ASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGI
| |... |.. |.|    .. |.  |    ...... .  | || |||| |||||||.|| |....|...||||||.||.| 
vedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 334-404 5.5e-17 56.9 In-house 14-86 (325) alignment 
Range on Protein: 334-404
Range on HMM: 14-86/325.0
VQNN--RRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
|...  .   .|  |. ||||  ..  ..| .|.|| |||..|..|.|.|||.||  |  |.||||||||.. 
vekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 335-406 7.2e-17 56.4 In-house 14-87 (288) alignment 
Range on Protein: 335-406
Range on HMM: 14-87/288.0
QNNRRSR-AFEDEWSLL-PSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
. ..|.|  |..|.  | . . .. .....|..|. ||||||||.||. || |.... ....||||||||.| .
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek
PTPc_DSPc_SM00012 639-753 8.9e-17 56.6 In-house 2-103 (105) alignment 
Range on Protein: 639-753
Range on HMM: 2-103/105.0
IRQFEVQTWPTWiqsdGVQSQEqcmDAVLQLMDYLHKCEIQRSTeqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQNLRLLRLSRP
...... .||      || ..    |..|.|.....|.. ....       ..|..|||  |.  .|.|...  .|.||..  . .|.|| .. || .||
vkhyhytgwpdh....gvPees...dsilellravkknknkses.......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp

NFVPTLTDYLLCYKLL
. | |...|| .|. |
gmvqteeqylflyral
subfamily_CG42327_pd Subfamily CG42327 440-508 1.3e-16 55.2 In-house 241-310 (319) alignment 
Range on Protein: 440-508
Range on HMM: 241-310/319.0
SQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRS-DQIDIFSFINSMRNNRPQMVQTPEQYAFVHEA
| ..  .||| |||| |.||||..|| |  .|. . |   .||   . |.|..| . |.| |||.|..  
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 338-407 1.6e-16 55.3 In-house 12-82 (281) alignment 
Range on Protein: 338-407
Range on HMM: 12-82/281.0
RRSRAFEDEWSLLPS-GLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
  .. |  |.. | . |...... .  ..|..||||.|| |||..|| ... .   ..|||||....|...
ndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg
subfamily_PTPRN_pd Subfamily PTPRN 553-751 2.5e-16 54.2 In-house 98-286 (297) alignment 
Range on Protein: 553-751
Range on HMM: 98-286/297.0
KKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNTrSVTFGPFTVgHKGSENM--NRVKVRTLELKY--KEEVHEIRQFEVQ
.. |.|||| || ||| |||..| .  .  |..| .|..   | |. ||| .  | ... . | |  || .  .   ||.. ||   ..|   . ||   
rapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyev.hlvsehiwcddylvrsfylknlqtsetrtvtqfhfl

TWPTwiqsDGVQSQEQcmdAvlqLMDYlhkceiQRSTEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQNLRLLRLSRPNFVPTLT
.||      || .. .   .   |...      .|  ..|  |   ||.||| .|   .||.. .   |..|..    ||.   |  ||  ||..| |  
swpe....egvPasak...s...llef......rrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd

DYLLCYK
.. ....
qfefalt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 631-754 3.1e-16 53.8 In-house 272-382 (392) alignment 
Range on Protein: 631-754
Range on HMM: 272-382/392.0
KYKEEVHEIRQFEVQTWPTWiQSDgvqsQEQCMDAVLQLMDylhkcEIQRSTEQSRpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
.     | . |..   ||    ||    |..   ..|.|.       .. ||.. .      ||||||||   .||||| |.|. |. .  ..|.|| ..
rslkashtvtqyqfhgwpkh.gsd....qqsgarsllklir.....avkgstnskk...efsilvhclsgagrtgvfctameciaqiaegdsvdifqtvk

LLRLSRPNFVPTLTDYLLCYKLLT
.||  | .|| |  .| . |..  
ilradrmqfvqteeeyafvydvir
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 407-513 5.5e-16 53.3 In-house 163-295 (297) alignment 
Range on Protein: 407-513
Range on HMM: 163-295/297.0
SRTLKQYHYQGWPDKGVP-------KF---------AGPV-LKMIQ--------DVNE-SQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQID
|| ..   . .|||.|||       .|         | |. | ...         ..    |.  | .|||||||| ||.||..  | ||   ..    |
srvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripd

IFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGL
. .... .|..|...||| ||. ....|||. |
vaailsilreqrarlvqtleqfellydavlkkl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 359-407 1.1e-15 52.7 In-house 54-102 (319) alignment 
Range on Protein: 359-407
Range on HMM: 54-102/319.0
QIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
. | |..|| |||. ||||.|...| || . |.  |||||||...|  .
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 407-511 1.3e-15 51.8 In-house 182-281 (290) alignment 
Range on Protein: 407-511
Range on HMM: 182-281/290.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESqekagNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
.  || .. . |||| |.. .  .|.... . .      .||. |||||| |||| ..|..  |.      ..|.   . ..|| | . ||   ||  . 
ehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalv

EAVLE
|..|.
eilld
subfamily_PTPRG_pd Subfamily PTPRG 342-405 3e-15 50.5 In-house 20-87 (563) alignment 
Range on Protein: 342-405
Range on HMM: 20-87/563.0
AFEDEWS-LLPSGLSQ--PSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDS-DYINASYINGI
 |. |.  |     |.  . . .. |.|| |||| ||.|||.||| |... |. .. |||||.||.| 
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy
subfamily_Ptp69D_pd Subfamily Ptp69D 325-407 3.1e-15 51.1 In-house 4-89 (307) alignment 
Range on Protein: 325-407
Range on HMM: 4-89/307.0
IIVADFADYVQNNRRSR--AFEDEWSLLP-SGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
| . | .. .....|     .. |.  |. .  .. ....   .|..|||| .| |.|. ||.|....|  ||||||||.|.| . 
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 360-407 3.5e-15 51.2 In-house 19-66 (284) alignment 
Range on Protein: 360-407
Range on HMM: 19-66/284.0
IASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
 | |..|| |||. .|||.|...| || . |.  |||||||.|.|  .
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 409-512 3.9e-15 50.3 In-house 189-288 (305) alignment 
Range on Protein: 409-512
Range on HMM: 189-288/305.0
TLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQekagnGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQI-DIFSFINSMRNNRPQMVQTPEQYAFVHE
.... ..  |||.|||      |...  .  |.      |..|||||| |||| |.|.. || .     .   .  .....|..|   .|.  || |.| 
svrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihr

AVLEG
 .|. 
vmlny
0044763 (Phosphotyrosine protein) phosphatases II 557-755 4.9e-15 51.1 In-house 31-169 (178) alignment 
Range on Protein: 557-755
Range on HMM: 31-169/178.0
FIATQMPldstvLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNTRsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqFEVQTWptWIQS
..... |      |...|.....|..|..|..        |  ||| ..                                       .... .   |  
ylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhi..pipD

DGVQSQEQCMDAVLQLMDYLHkceiqrsteqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQlnndgAIDVFQNLRLLRLSRPnFVPTLTDYLLCYKLL
.||..  . ......... ..            . .| |.||||  |.  ||...    ....      ..... ..|.|  || .||.  ..  .|.. 
hgvpdllehflefvefieeal............dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefe

TH
 .
lr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 546-749 5.4e-15 50.2 In-house 44-232 (239) alignment 
Range on Protein: 546-749
Range on HMM: 44-232/239.0
QEFEGYSKknAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN---DKTCSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKEEV--HEIR
....|  |  |.||||  .  .  ||||.. . .   |.||  |     | |  ||| .|    .  . |  . .| .    .||. .    .   . . 
rdydgspk..ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvy

QFEVQTWPtwiqSDGVQsqeQCMDAVLQLMdylhkceiQRSTEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFV
|. .  ||      ||    |   ||| |         .. |..| ||   | ..|| .|.  .| |  .   | | ... ..|.|. .. .|  || .|
qyhftvwp....dkgvp...qyatavlglr........rkitkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

PTLTDYLLC
 |  .|.. 
qtseqyvfi
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 546-749 5.5e-15 50.2 In-house 45-233 (239) alignment 
Range on Protein: 546-749
Range on HMM: 45-233/239.0
QEFEGYSKknAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLN---DKTCSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKEEV--HEIR
....|  |  |.||||  .  .  ||||.. . .   |.||  |     | |  ||| .|    .  . |  . .| .    .||. .    .   . . 
rdydgspk..ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvy

QFEVQTWPtwiqSDGVQsqeQCMDAVLQLMdylhkceiQRSTEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFV
|. .  ||      ||    |   ||| |         .. |..| ||   | ..|| .|.  .| |  .   | | ... ..|.|. .. .|  || .|
qyhftvwp....dkgvp...qyatavlglr........rkitkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

PTLTDYLLC
 |  .|.. 
qtseqyvfi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 360-408 6.4e-15 50.0 In-house 3-51 (250) alignment 
Range on Protein: 360-408
Range on HMM: 3-51/250.0
IASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIESR
.|  |.|| |||| .|.|.|.|||.||..||  .|||||||...| . |
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 405-505 6.4e-15 49.7 In-house 178-273 (301) alignment 
Range on Protein: 405-505
Range on HMM: 178-273/301.0
IESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkagngPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAF
...||.  | |. |.|.||||    . .... | .|..     |..|||||| ||.   |. . . || .   .|..   .. .|..| . ||| .|  .
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

V
.
m
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 450-516 1.1e-14 48.6 In-house 2-68 (69) alignment 
Range on Protein: 450-516
Range on HMM: 2-68/69.0
LVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCG
.||||.|.|||| .||.   .   |    .|||  .. ||  || ||    .| |.|.|. | |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 554-740 1.1e-14 48.9 In-house 89-264 (301) alignment 
Range on Protein: 554-740
Range on HMM: 89-264/301.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNTR-SVTFGPFTVGHKGSENMNR--VKVRTLELKYKEEVHEIRQFEVQTW
 . ||||| ||..|  ||| ..  |.. .|.|| |  .   . |. | ||... ..  | |..  | .| . .  .. ||||..   .  . |      .
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

PTWIQSDGVQSQEQCMDavlqLMDYLHKCEiqrsteQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFV
 .| . .  .|  ...|    ||. . | |      .       ||.||| .||  |  | .      ....|  |.. . |. ||  | | |
sewtdrgvPkshaelfd....lmelvkkse......k.......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-406 1.2e-14 48.9 In-house 4-89 (315) alignment 
Range on Protein: 323-406
Range on HMM: 4-89/315.0
RPIIVADFADYVQNNRRS--RAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
.|| . ..  || ... |    |....  .| |  .| ..|   .|| |||| ||.|||.||| |  ..  |.|||.||..|.| .
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 412-510 1.4e-14 48.6 In-house 219-341 (350) alignment 
Range on Protein: 412-510
Range on HMM: 219-341/350.0
QYHYQGWPDKGVPKFAGPVLKMIQ------DVNESQ---EKAGNGPLLVHCSAGAGRTGVIIAVDSILR-------EAKRSDQID--------IFSFINS
| ... |.| ..      .|....      | . ..   ..|   |.||||||| ||||.....||.|          |.| ..|        |.  .| 
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

MRNNRPQMVQTPEQYAFVHEAVL
.|. | .|||. .|. |..||.|
lrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 451-516 2e-14 47.7 In-house 2-67 (69) alignment 
Range on Protein: 451-516
Range on HMM: 2-67/69.0
VHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLLCG
||||.|.||||  ||.   .   |    .|||  .. ||  || ||   ..| |.|.|. | |  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 554-755 4.5e-14 46.8 In-house 80-267 (281) alignment 
Range on Protein: 554-755
Range on HMM: 80-267/281.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL---NDKTCSIYWPVNTRS-VTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQTWPT
|  .| || |   |  ||||.. .   ..|.|| |.   | . |. |.| |..  . |  ..| .. |   . .    |.| |. | . | ..  . || 
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpd

WIQSDgvqSQEqCMdavLQLmdyLHKCEiQRSTeqsrpgdgPPIlVHCLSGIEESGVFCTVMNCLEQLNNDGAI-DVFQNLRLLRL-SRPNFVPTLTDYL
|   .   | |  |   |..   |.|    |||        ||. .|| .|.  || . .|  .|. . .  .. |. | .  ||.  |   | || .|.
wqvpe...sse.vm...lki...lrkir.arst........ppv.ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqym

LCYKLLTH
| .|.|  
liwkvlld
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 407-514 1e-13 45.4 In-house 187-289 (302) alignment 
Range on Protein: 407-514
Range on HMM: 187-289/302.0
SRTLKQYHYQGWPDKGVPKFAGPVLKMIQdVNESQEKAgngpLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
 .|..  .. .|||.| || | . |....   ||  |.    .||||||| |||| ..|.   .   .. .  |. | .  .|. |   ||. .|  .. 
kktvdilafsawpdhGapkeaytaldilk.fcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

EAVLEGLL
  |  ||.
lcvtkglm
subfamily_PTPN12_pd Subfamily PTPN12 357-407 1.6e-13 45.2 In-house 31-81 (290) alignment 
Range on Protein: 357-407
Range on HMM: 31-81/290.0
PSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
... .. ..|. ||||..|| ||.|||.|.. .....||||||..|.| |.
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 406-511 1.8e-13 45.2 In-house 114-219 (255) alignment 
Range on Protein: 406-511
Range on HMM: 114-219/255.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQekagngPLLVHCSAGAGRTGVIIAVDSILR------EAKRSDQIDIFSFINSMRNNRPQMVQTP
. .|.| |.|.||..|  |. |  .|.... | .|.      ...||||.| ||.   . .... .      .     ..|  |... .|..|.. ..||
kthtvkhysykGWieknaPelareilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP

EQYAFVHEAVLE
 | ||    ||.
lqlafsilmvld
subfamily_egg_pd Subfamily egg 552-769 2.5e-13 44.4 In-house 80-285 (307) alignment 
Range on Protein: 552-769
Range on HMM: 80-285/307.0
SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND-KTCSIYWPVNT-RSVTF--GPFTVGHKGSENMNRVKVRTLELKYKEEVheirqfevqtw
   | || .| ||  || ||||.|.  ..  |.||.   . . |  |||     |. .  | . .   . ..      |  .||                
pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd...........

ptwiqsDGVQSQEQCMDAVLQLMDYLHKCEIQRSTEQSrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGA--IDVFQNLRLLRLSRPNFVPTLTD
      |  .  |     | .. |     .. |   .       |..|..  |.  .... ..   | .|         | .   .||| |.  | .   
......deerflehwqgdvnnssdvysplrvlrklrnl....skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvll

YLLCYKLLT-HHHTLCRSEEELDY--E
||. |.|.    . .  | .|||   |
ylfvyrlvlfffrdvigsakeldvdye
DSPc_SM00195 357-404 4e-13 44.7 In-house 17-64 (263) alignment 
Range on Protein: 357-404
Range on HMM: 17-64/263.0
PSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
... |  ..|| ||||.||| |||.|| |.. .. ..||||||.||.|
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikg
PTPc_SM00194 357-404 4e-13 44.7 In-house 17-64 (263) alignment 
Range on Protein: 357-404
Range on HMM: 17-64/263.0
PSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
... |  ..|| ||||.||| |||.|| |.. .. ..||||||.||.|
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikg
subfamily_PTPN6_pd Subfamily PTPN6 359-404 4.3e-13 43.9 In-house 47-91 (306) alignment 
Range on Protein: 359-404
Range on HMM: 47-91/306.0
QIASLPNNKVKNRYRNILAYDHSRVMLEeVKGVPDSDYINASYING
. .. |.|| ||||.||| .||.||.|.  ..||.||||||.||..
kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 404-514 4.6e-13 43.5 In-house 173-277 (312) alignment 
Range on Protein: 404-514
Range on HMM: 173-277/312.0
GIESRtLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkagngPLLVHCSAGAGRTGVIIAVDSIL---REAKRSDQIDIFSFinsMRNNRPQMVQTPE
| ||. |..| .  |||.|.|      |...  |.  .      |.. ||||| |||| .. ..|..   |  .. .  |.| .   .|..| . |..  
gqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfp

QYAFVHEAVLEGLL
|| ..  .||| | 
qyvyalrcvlefly
subfamily_ptpA1_pd Subfamily ptpA1 555-717 5.2e-13 43.5 In-house 89-256 (418) alignment 
Range on Protein: 555-717
Range on HMM: 89-256/418.0
NAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHK--GSENM----------NRVKVRTLELKYKEEVHEI
. ||.|| ||  |. ||||.| . .   |.||.. ...    |  ||| .     |  .  | .  |. ..            .  | . | .. | ..|
kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrdi

RQFEVQTWPTWIQSDGVQSQEQCMDAVLQlmdylHKCEIQRSTEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQL
 |.. . ||     |  |   | . .. .     .. .|  |...       ||.||| .|.  .| ||| .  ...|
tqyqyegwpdhnipdhtqpfrqllhsitn.....rqnqiipssdrnv.....piivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 413-509 1e-12 42.1 In-house 186-281 (302) alignment 
Range on Protein: 413-509
Range on HMM: 186-281/302.0
YHYQGWPDKGVPKFAGPVLKMIQDVNESQeKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAV
|. . |..| ||.  . . | ...| ...   .. ....    |||| |.....   . . .....  |   ..|.|..||..|.. .||.... |.
yvltnWkqkkvpvkyaeliktaakvfakk.ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_PTPN9_pd Subfamily PTPN9 328-405 1.9e-12 41.8 In-house 4-81 (297) alignment 
Range on Protein: 328-405
Range on HMM: 4-81/297.0
ADFADYVQNNRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGI
 .. .||......   ..   .     .   . . |. |  |||| ..| ||..||.|..|.. . ||||||....| 
eelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy
subfamily_PTPRK_pd Subfamily PTPRK 327-404 2.6e-12 41.2 In-house 6-81 (314) alignment 
Range on Protein: 327-404
Range on HMM: 6-81/314.0
VADFADYVQNNRR--SRAFEDEWSLLPSGlsqpSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
|||  . ..  .|  .  | .|.  |. |     . |   .|. |||. .|||||.|||.|  ..| |.||||||..|..
vadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalids
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 324-407 2.7e-12 41.5 In-house 3-87 (305) alignment 
Range on Protein: 324-407
Range on HMM: 3-87/305.0
PIIVADFADYVQNNRR--SRAFEDEWSLLPSGlSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIES
.| ..|.| |....|   ....| .. .|..  ... .. .  .|| |||...|  .|..|..| | . ..|||||||||..| ..
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 365-403 5.2e-12 40.4 In-house 7-45 (239) alignment 
Range on Protein: 365-403
Range on HMM: 7-45/239.0
NNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYIN
 || |||| ||..||||||.||..   | ||||||||. 
vnkaknryanivtydhsrvvleklsndphsdyinasylr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 366-403 5.2e-12 40.4 In-house 7-44 (239) alignment 
Range on Protein: 366-403
Range on HMM: 7-44/239.0
NKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYIN
|| |||| ||..||||||.||..   | ||||||||. 
nkaknryanivtydhsrvvleklsndphsdyinasylr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 326-406 5.4e-12 40.2 In-house 3-88 (290) alignment 
Range on Protein: 326-406
Range on HMM: 3-88/290.0
IVADFADYVQNNR--RSRAFEDEWSLLPSGLSQPSQ-IASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPD--SDYINASYINGIE
 | .|...|.|..    . |....  | || |. .  ..  ..|| .||..||. ||  |..| .. | .|   .||||.||.| .
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 414-509 1.5e-11 38.4 In-house 196-286 (310) alignment 
Range on Protein: 414-509
Range on HMM: 196-286/310.0
HYQGWPDKGVPKFAGPVlkMIQDVnESQekAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAV
..  |||.|||        . | .  .|     || .|||||| .|..|..|..  .  ..| ...|.   .  ....| . .||. || ...   
kwpnwpdrgvpdekcht..vpqrl.laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
PTEN_1 399-506 1.7e-11 39.3 In-house 83-186 (196) alignment 
Range on Protein: 399-506
Range on HMM: 83-186/196.0
ASYINGIESRTLKQYHYQGWPDKGVPKFAgPVLKMIQDVNESQEKAG-NGPLLVHCSAGAGRTGVIIAvdSILREAKRSDQIDIFSFINSMR-NNRPQmv
.|| . .. .   .|.  ...| |.| ..  ..... .. |.  ..  ..  |||| || ||.|...|  . | ......  . .......| ...|.  
rsydleeffksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva..ayLmykgkltadeAlelvrekRppgapn..

qTPEQYAFVH
 .|.| ....
.spsqerlle
subfamily_CG42327_pd Subfamily CG42327 552-675 1.8e-11 38.2 In-house 69-196 (319) alignment 
Range on Protein: 552-675
Range on HMM: 69-196/319.0
SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKT---CSIYWPVNT---RSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEvHEIRQFEvQ
. .| .||.|..|...  ||||.| .    .|. | .| ..    |. |.| .       ..| . |  || |  .|  . || ||  .. .| |.    
dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdk.eesrelt.h

TWPTWIQSDgVQSQEQC-MDAVLQLMDYLHK
 |  |.... | ..|.  .  .|.  . |. 
ywykwleae.vPaeeaaliamllevrsslks
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 416-514 2e-11 38.4 In-house 175-271 (285) alignment 
Range on Protein: 416-514
Range on HMM: 175-271/285.0
QGWPDKGVPKFAGPVLKMIQDVNESQEKagNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVHEAVLEGLL
  |||.  |. | |.... . |.. . |  . |. |||||| |||  .. .|          .|...  .  ||  | | ||.  |. |..  ..| ..
pwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 343-404 2.6e-11 37.6 In-house 22-86 (439) alignment 
Range on Protein: 343-404
Range on HMM: 22-86/439.0
FEDEWSLLPSGLSQPSQIASL---PNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
|....  . |   . . ||||     .. ||||... |.||.||.|.|. ||| | |||| ||.|
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 441-510 3.3e-11 37.1 In-house 260-341 (349) alignment 
Range on Protein: 441-510
Range on HMM: 260-341/349.0
QEKAGNGPLLVHCSAGAGRTGVIIAVDSILR----EAKRSDQID--------IFSFINSMRNNRPQMVQTPEQYAFVHEAVL
 ...   .|||||||| |||||.. .|..|       . | .|.        |.  .|..|  | .|||   |. ...||.|
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_hpo-7_pd Subfamily hpo-7 404-511 7.4e-11 36.4 In-house 118-225 (263) alignment 
Range on Protein: 404-511
Range on HMM: 118-225/263.0
GIESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEkagngpLLVHCSAGAGRTGVIIAVDSILR------EAKRSDQIDIFSFINSMRNNRPQMVQ
 .. .|.|.| |.||..|  |. |  .|.... . .|..      | ||||.| ||.     .... .      .     ..|  |... .|..|.. ..
KkkthtvkhysykgWiekndpelareilnilkvarnsks......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraih

TPEQYAFVHEAVLE
|| | ||    ||.
tPmqLafsilmvLd
0048076 (Phosphotyrosine protein) phosphatases II 608-754 7.8e-11 37.3 In-house 36-140 (145) alignment 
Range on Protein: 608-754
Range on HMM: 36-140/145.0
GpftvghkgsenmnrvkvrtlelKYKEEVHEirQFEVQTWPTWIQSDGVQSQEQCMDAVLQLMDYLHKCeiqrsteqsrpgdGPPILVHCLSGIEESGVF
                        . .| .|  .. .| . . .   ||..  . ....|.... ..|              | |.||||  |.  .|..
l......................tselelle..rlgiqylylpwpDhgvpdllellleflefieealke.............ggpvlVHCsaGvgRtgtl

CTVMNCLEqlnnDGaIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
.  . .|.     | ..... |.|.|  ||..||.   .  .|....
vaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 365-406 1.6e-10 35.6 In-house 2-41 (237) alignment 
Range on Protein: 365-406
Range on HMM: 2-41/237.0
NNKVKNRYRNILAYDHSRVMLEEVKGVpdSDYINASYINGIE
.||.|||| || |||||||.|.   .   ||||||.|..|..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 407-506 1.9e-10 35.3 In-house 94-197 (199) alignment 
Range on Protein: 407-506
Range on HMM: 94-197/199.0
SRTLKQYHYQGWPDKGVPKFAGPVLK--MIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAK--RSDQIDIFSFINSMRNNRPQMVQTPEQY
.| . .| .  | .|  |. |  |      ..|    |.  . |..|||| | | |||..|.|  .|  .  ..  .|.|   . .|. |  .. . ..|
treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

AFVH
 |..
nfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 407-506 1.9e-10 35.3 In-house 93-196 (198) alignment 
Range on Protein: 407-506
Range on HMM: 93-196/198.0
SRTLKQYHYQGWPDKGVPKFAGPVLK--MIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAK--RSDQIDIFSFINSMRNNRPQMVQTPEQY
.| . .| .  | .|  |. |  |      ..|    |.  . |..|||| | | |||..|.|  .|  .  ..  .|.|   . .|. |  .. . ..|
treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

AFVH
 |..
nfiy
subfamily_PTPDC1_pd Subfamily PTPDC1 413-507 1.9e-10 35.5 In-house 85-170 (182) alignment 
Range on Protein: 413-507
Range on HMM: 85-170/182.0
YHYQGWPDKGVPKFAgPVLKMIQDVNESQEkagNGPLLVHCSAGAGRTGVIIAVDSILREAKRSDQIdifsfINSMRNNRPQMVQTPEQYAFVHE
..  ||.| ||.     .| ... |. . .   .| . ||| || |||||.||.  .  .   ...      |. .|..||. .|| ||  .|.|
vynfgwkDygvasle.riLdivkvvafalq...egkvavhChaGlGrtGvliacylvyakrltaeka.....iklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 553-755 1.9e-10 35.2 In-house 80-275 (307) alignment 
Range on Protein: 553-755
Range on HMM: 80-275/307.0
KKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVN-TRSVTFGP----FTVGHKGSENM----NRVKVRTLELKYKEEVHEIR
| . ||..| ||..|. .|| .. . .. ..||| .. .     |  |||..  .  .||      .|   |....    . ..| ||.... ..   |.
kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiq

QFEVQTWPtwiqSDGVQSQEqcMDAVlQLMDylhkceIQRsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN-NDGAIDVFQNLRLLRLSRPNF
... . ||      ||   .  . |.  |..        |       .|  |..||| .|.  ||   ..    ...       |. . .. ||  |.  
hlqwenwp....drgvpqin..ltai.nlle......avr.......ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhya

VPTLTDYLLCYKLLTH
. |   ||  ...| .
iqteaqylylhrvlle
subfamily_PTPN3_pd Subfamily PTPN3 359-403 2e-10 35.1 In-house 34-74 (280) alignment 
Range on Protein: 359-403
Range on HMM: 34-74/280.0
QIASLPNNKVKNRYRNILAYDHSRVMLEEVKgvpdSDYINASYIN
..| .|.| .|||||.||.||. ||.|.| .    .|||||.|.|
saarkpenlsknryrdilpydatrvklkese....tdyinanyvn
subfamily_ptpA1_pd Subfamily ptpA1 406-465 3.5e-10 34.2 In-house 184-248 (418) alignment 
Range on Protein: 406-465
Range on HMM: 184-248/418.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQEK-----AGNGPLLVHCSAGAGRTGVIIA
|.| . ||.|.||||. .| .. |. .... . . |..       | |..|||||| |||| . .
etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 555-750 3.8e-10 33.9 In-house 96-282 (305) alignment 
Range on Protein: 555-750
Range on HMM: 96-282/305.0
NAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQ---LNDKTCSIYWPVNT---RSVTFGPFTVGHKGSENMNR---VKVRTLELKY-KEEVHEIRQFEV
. ||..| ||| |. .|| .| . ..  |.|| .   |    |. |||.     ...  |       ||  |.|   ... .|.| |  ..   .|... 
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqw

QTWPtwiqSDGVQsqeQCMDAVLQLMDYLhkceiQrsteqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQN-LRLLRLSRPNFVPTL
  ||      ||     |  . |.|.  .     .        |   ||.||| .||  .|   ..   ||.. ..     . . .. ||  |   . . 
tewp....drgvp...pckltslellsai.....r........gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqnd

TDYLLCY
 .||  .
vqylfih
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 554-754 4.3e-10 33.8 In-house 87-284 (305) alignment 
Range on Protein: 554-754
Range on HMM: 87-284/305.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTfgPFtvGHKGSEnMnRVKVR-TLELKYKEEvheiRQFEVQTWPT
 . || || ||. |  ||| .  . .. .|.|| .| .|    |. |.. . . |    |    ||   .  ||.  . .||....     . .|.    
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl..ef..eekgqk.i.svkfessvtlkfrkd....akakvtetvl

WIQSDGVQSQEQCMDAVLQLMDYL---HKCEIQRSTEQSRPGDGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ-NLRLLRLSRPNFVPTLTD
 |.  | ...        .  |         |    |..||  || | ||| .||  .|    .   |.|| .   |.  .  |. .|  | | . | ..
viegpgekarkvthyhwidwpdrgvpaadlailellekarpskgp.ivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq

YLLCYKLLT
||. .... 
ylfvhqvil
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 554-725 5.5e-10 33.3 In-house 93-258 (310) alignment 
Range on Protein: 554-725
Range on HMM: 93-258/310.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKgSENMNRVKVRTLELKY-------KEEVHEIRQFE
...|| .| ||. |..||||.. .    .|..| .  ..    |  |||    . |.|   |    ||  .  ..  | . .        |.  ..... 
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelr

VQ--TWPTWIQSdGVqSQEQCmdavlqlmdylhKCEIQRSTEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
|.   || | .  ||  .|.|            .   ||   | | |   | .||| .|..  .| ...   ...|..   .|.
vslikwpnwpdr.gv.pdekc............htvpqrllaqvrhg...pcvvhcsagkdrlyvvvalklkidkldrglkvda
subfamily_CG7180_pd Subfamily CG7180 359-404 6.2e-10 33.2 In-house 35-80 (296) alignment 
Range on Protein: 359-404
Range on HMM: 35-80/296.0
QIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYING
. .   .|. |||. ... ||. ||.||...|  .||||||.|...
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvds
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 553-755 8e-10 33.2 In-house 80-269 (288) alignment 
Range on Protein: 553-755
Range on HMM: 80-269/288.0
KKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKT---CSIYWPVNT-RSVTFGPF-TVGHKGSENMNRVKVRTLeLKYKEEVHEIRQFEVQTW
 |. .| .| ||..|.  .|... .  .  |.||..| .|       |.|..  ... .| . ||  |  ...... . .| |. ..|..|     .  .
ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsl.lriskegeekvivkilhl

PTWIQsDGVQSqeqcmdavlQLMDYLHKCEIQRSTEQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYL
  | . |||           . . .|. .|. .|...       ||.||.  |.  .| .  ..  ||.|  |  . . . |  || .| . . |   ||
leWdd.dgvPe.........nylsplrllevlkslqk.......PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqyl

LCYKLLTH
  .... .
yvhrcvle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 351-409 9.3e-10 32.9 In-house 5-63 (270) alignment 
Range on Protein: 351-409
Range on HMM: 5-63/270.0
PSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIESRT
. . ...|.. .  ..|. |||..||   ..||.|||..  . . |||| |..|.....
dkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgek
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 549-648 1.1e-09 32.3 In-house 82-143 (392) alignment 
Range on Protein: 549-648
Range on HMM: 82-143/392.0
EGYSKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKTcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkYKEEVHEIRQFEVQTWP
...  ..|.||.|.|  ... ||||.|.. ...||.|...|..                                          .... . || .  ||
psfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......................................kgddartvaqfhftewP
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 406-511 1.2e-09 32.3 In-house 165-267 (281) alignment 
Range on Protein: 406-511
Range on HMM: 165-267/281.0
ESRTLKQYHYQGWPDKGVPKFAGPVLKMIQDVnesqeKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRSD-QIDIFSFINSMR-NNRPQMVQTPEQYA
|.| . .. .. |||  ||. .  .||... .     .|   | ..||||| ||.| ..||.  |.  .      ||   .  .|   |   ||| .|| 
etrlithwlwkewpdwqvpessevmlkilrki.....rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqym

FVHEAVLE
.. . .|.
liwkvlld
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 340-407 1.6e-09 32.2 In-house 4-70 (274) alignment 
Range on Protein: 340-407
Range on HMM: 4-70/274.0
SRAFEDEWSLLPSGLsQPsQIASLPNNKVKNRYRNILAYDHSRVMLEEVKG-VPDSDYINASYINGIES
.. .|.|.  ||.   .. .  ... .. ||||..||  ..|||.||. ..  .||.|||| || | . 
fkdlekeflelPlnf.dq.eeldvfgsqtknryktilPnensrvllesessededssyinanyikGyde
subfamily_PTPN1_pd Subfamily PTPN1 357-403 1.6e-09 31.9 In-house 23-65 (290) alignment 
Range on Protein: 357-403
Range on HMM: 23-65/290.0
PSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGvpdsDYINASYIN
| . | ||.|. .||||..  |||||..||. .     |||||| ..
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslve
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 327-407 2.2e-09 31.7 In-house 4-84 (287) alignment 
Range on Protein: 327-407
Range on HMM: 4-84/287.0
VADFADYVQNNR--RSRAFEDEWSLLPSGLSQPSQIA--SLPNNKVKNRYRNILAYDHSRVMLEevkgVPDSDYINASYINGIES
|  |...|....   .  |.. . .| .   .. ..     ..|| |||...|| .|  ||.|.      . |||||..|.| ..
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyke
0048179 (Phosphotyrosine protein) phosphatases II 649-751 2.3e-09 32.7 In-house 55-139 (144) alignment 
Range on Protein: 649-751
Range on HMM: 55-139/144.0
TWIQSDGVQSQEQCMDAVLQLMDYLhkceiqrsteqsRPgDGPPILVHCLSGIEESGVFCTVMNCLeqlnNDGaIDVFQNLRLLRLSRPNFVPTLTDYLL
. .   || .  . ....|.... .            .. .| |.||||  |.  .|....   ..      | ..... |.|.|  ||. ||.   .  
lpwpDhgvpdllellleflefieea............le.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf

CYK
...
Lle
Y_phosphatase Protein-tyrosine phosphatase 366-404 2.4e-09 32.3 Pfam-A 1-37 (235) alignment 
Range on Protein: 366-404
Range on HMM: 1-37/235.0
NKVKNRYRNILAYDHSRVMLeevKGVPD-SDYINASYING
|| ||||..||.||..|| |   || .. ||||||.|..|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkg
Y_phosphatase Protein-tyrosine phosphatase 366-404 2.4e-09 32.3 In-house 1-37 (235) alignment 
Range on Protein: 366-404
Range on HMM: 1-37/235.0
NKVKNRYRNILAYDHSRVMLeevKGVPD-SDYINASYING
|| ||||..||.||..|| |   || .. ||||||.|..|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkg
subfamily_PTPRN_pd Subfamily PTPRN 326-406 2.6e-09 31.2 In-house 17-96 (297) alignment 
Range on Protein: 326-406
Range on HMM: 17-96/297.0
IVADFADYVQNNRRsraFEDEWSLLPSGLSQPSQ--IASLPNNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGIE
... . |...|. |   .| ||  | .  ..||   .|. ..|  |||....|.|||||| |.|     .||||||| |   .
vlsyledhlknkdr...lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd
subfamily_PTPN23_pd Subfamily PTPN23 345-407 3.3e-09 31.0 In-house 19-80 (288) alignment 
Range on Protein: 345-407
Range on HMM: 19-80/288.0
DEWSLLPSGLSQPS---QIASLPNNKVKNRYRNILAYDHSRVMLEevkgVPDSDYINASYINGIES
 .. .| .   . .    ||    .  |||.|.|| |||.||.|.        ||||||..... .
kkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlsp
0038934 (Phosphotyrosine protein) phosphatases II 412-503 3.3e-09 32.1 In-house 81-167 (194) alignment 
Range on Protein: 412-503
Range on HMM: 81-167/194.0
QYHYQGWPDKGVPKFAGPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILReakrsDQIDIFSFINSMRNNRPQMVQTPEQYA
.|.   .||.|..     .|. .. |.|  ..  .|  .||| || ||||...|   | |      ...    |. .|  || ........ 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 337-408 3.9e-09 30.6 In-house 11-84 (301) alignment 
Range on Protein: 337-408
Range on HMM: 11-84/301.0
NRRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKG--VPDSDYINASYINGIESR
. .|  ||.... | .| ......    .||. ||..||  ||. |..|.. .   .   .|||||||.|. ..
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 364-402 1.2e-08 29.1 In-house 31-67 (297) alignment 
Range on Protein: 364-402
Range on HMM: 31-67/297.0
PNNKVKNRYRNILAYDHSRVMLEevKGVPDSDYINASYI
..   |||||.|||.| .|| |   ......||||| |.
nsslrknryrdilatddtrvkll..rviterdyinadyv
subfamily_eak_pd Subfamily eak 556-648 1.2e-08 28.8 In-house 94-190 (332) alignment 
Range on Protein: 556-648
Range on HMM: 94-190/332.0
AFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQ-LNDK--TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQTWP
 .| | .. .. |  ||..| . .  .|..| . .. |      |.| .||  . || . |  |   . | ...| |||.  .| |..  ..|  | 
kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 324-406 1.7e-08 28.5 In-house 4-85 (95) alignment 
Range on Protein: 324-406
Range on HMM: 4-85/95.0
PIIVADFADYVQNN--RRSRAFEDEWSLLPSGLSQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKgvpDSDYINASYINGIE
|| |. |  .| .      . |..|.  ..     |  . |   |  |||. ||. || .||.|   .   ||||||| ...|  
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgya
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 556-738 1.7e-08 29.0 In-house 61-240 (290) alignment 
Range on Protein: 556-738
Range on HMM: 61-240/290.0
AFIATQMPL-------DSTVLDFWRLVHDYHISTIIMLNQLNDK-------TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV-HEI
..|.|| |.       .||. .|| .... ..  ..|| . ..|       .|. | | .   ...|. .||  |  |. . |..|.|..|. .|. . .
rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftv

RQFEVQTWptwIQSdGVQSQEQCMdavLQLMDYLHkCeiqrS-TeqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLN-NDGAIDVFQNLRLLRLSRP
    .. |    ..  || ... .   |.|..... .    | |         |..|||  ||  | .. ..      .    |.. . . |  ||  | 
tHsllkgW...nkl.nvqedtktl...lsliqkvk.a....skt.........pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

N
.
l
subfamily_PTEN_pd Subfamily PTEN 395-506 1.8e-08 29.6 In-house 63-173 (184) alignment 
Range on Protein: 395-506
Range on HMM: 63-173/184.0
DYINASYINGIESRTLK-QYHYQGWPDKGVPKFAgPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVdSILREAKRSDQIDIFSFINSMRNNRP
  .|    .  .|.... . .  .  |.  |..   . ....|...  |.  .    ||| || |||||.|.   .| . . ... .. .. ...| .  
kiynlrserkydskkfdgrvavypfdDhnppple.lleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknk

QMVQTPEQYAFVH
. |. | |  .|.
kgvtiPsqrRYve
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 408-510 1.8e-08 28.9 In-house 158-256 (290) alignment 
Range on Protein: 408-510
Range on HMM: 158-256/290.0
RTLKQYHYQGWPDKGVPKFAGPVLKMIQDVNESQekagnGPLLVHCSAGAGRTGVIIAVDSILRE-AKRSDQIDIFSFINSMRNNRPQMVQTPEQYAFVH
 |.. . ..|| .  |..    .|..|| |. |.      | .|||  |  |  .. |..      |. |... . . ....|..| .........||| 
ftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

EAVL
 ...
agiv
subfamily_PTPN14_pd Subfamily PTPN14 358-403 2.1e-08 28.5 In-house 41-85 (300) alignment 
Range on Protein: 358-403
Range on HMM: 41-85/300.0
SQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGVpDSDYINASYIN
 . |.||.|. |||....| |...|| |   |   ...||||| |.
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassik
fn3 Fibronectin type III domain 89-159 2.2e-08 27.3 Pfam-A 20-82 (85) alignment 
Range on Protein: 89-159
Range on HMM: 20-82/85.0
WKAENssldAGEGPIVGYIVYYHVDGSVQ-MAEFVSSDEsgmmgRYEYTVINLSPGITYSFSVAAVREGEGG
|.. .     |.|||.|| | |  .|. .   ||  .        ...|. .| || .|.|.|.|| .. .|
Wsppk....dgggpitgYeveyrekgggeewkeftvprt.....ttsvtltgLkpgteYefrVqavngageg
TMEM154 TMEM154 protein family 171-239 4.3e-08 24.6 Pfam-A 21-94 (146) alignment 
Range on Protein: 171-239
Range on HMM: 21-94/146.0
TL-PALMTTVPTSEA--STTTASGVTLALPTNDQ--VLLYIIIPVVIVICIIIIILIMVTIgvQRRKRRKM--YHN
|  .. ...|  .|.   ..  . . |   ..||  ..| |||| |. | ..... |.|..  ..|||||   . .
tvtastlasvtdpetlsanvnleegelseksadqaelvlmiiiPsvvLillllvvvilvik..kkrkrrKqeetse
subfamily_ptpA1_pd Subfamily ptpA1 365-405 4.6e-08 27.2 In-house 46-86 (418) alignment 
Range on Protein: 365-405
Range on HMM: 46-86/418.0
NNKVKNRYRNILAYDHSRVMLEEVKGVPDSDYINASYINGI
 |  |||| |||  .|.|| |....    |||||| ||.| 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 554-751 4.9e-08 27.4 In-house 4-198 (199) alignment 
Range on Protein: 554-751
Range on HMM: 4-198/199.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL--NDK-TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEE----VHEIRQFEVQ
.  .|||| ||  |. |||..| .     |.|.|.   | .   ..|||.    .  .| ..|  |         . .| |  .        || ...  
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWptwiqsdgvqsQEQCMDAVLQLMDY-LHKCEIQRSTEQSRpgDgPPILVHCLSGIEESGVFCTVMNCLEQLN--NDGAIDVFQNLRLLRLSRPNFVPT
.|           .|.    |  .. . .   |. .  || .  |  |..|||  |   .||| ..   .   .  .   .|.|.  . || .|   . .
sw...........kekttpnvalfvgfvvasrevskkyeqek..d.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

LTDYLLCYK
|  | . |.
lqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 555-751 5.4e-08 27.2 In-house 4-197 (198) alignment 
Range on Protein: 555-751
Range on HMM: 4-197/198.0
NAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL--NDK-TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEE----VHEIRQFEVQT
  .|||| ||  |. |||..| .     |.|.|.   | .   ..|||.    .  .| ..|  |         . .| |  .        || ...  .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WptwiqsdgvqsQEQCMDAVLQLMDY-LHKCEIQRSTEQSRpgDgPPILVHCLSGIEESGVFCTVMNCLEQLN--NDGAIDVFQNLRLLRLSRPNFVPTL
|           .|.    |  .. . .   |. .  || .  |  |..|||  |   .||| ..   .   .  .   .|.|.  . || .|   . .|
w...........kekttpnvalfvgfvvasrevskkyeqek..d.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl

TDYLLCYK
  | . |.
qhynfiyq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 556-601 8.8e-08 26.2 In-house 105-153 (350) alignment 
Range on Protein: 556-601
Range on HMM: 105-153/350.0
AFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQL---NDKTCSIYWPVN
 .|||| || ||| ||....   ..  |..|...   | . | .||.  
kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
subfamily_PTPN13_pd Subfamily PTPN13 360-403 1.2e-07 26.3 In-house 31-69 (273) alignment 
Range on Protein: 360-403
Range on HMM: 31-69/273.0
IASLPNNKVKNRYRNILAYDHSRVMLEEVKGvpdsdYINASYIN
..   .|| ||||||.| ||..|| |..  |     |||||.|.
vgkkkenkdknryrnvlPydetrvklgdegg.....yinaslik
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 554-754 1.3e-07 25.9 In-house 74-267 (285) alignment 
Range on Protein: 554-754
Range on HMM: 74-267/285.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWPVNT-RSVTFGPFTVG--HKGSENMNRVKVRTLELKYKEEVHEIRQFEVQT-
....|.|| ||  |. |||..... .|. ..||  | .   . |..|.| .    | || . .       | .    . .| .   |.      .  .  
qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvq

WPTWIqsDGVQSqEQcMDAVLQLMDYLHKCEiqrsteqsrPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDY
 | |   | .   |.    ...|  ...| .         | .  || ||| .|.  .  |  .  .  .. ..  |.... .| .|  | . | .  ..
vpwwp..dqlap.ed.arpmielykwvkkvn.........pkek.picvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqf

LLCYKLLT
|. | .| 
lflyvvlm
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 365-403 2.1e-07 25.0 In-house 46-92 (350) alignment 
Range on Protein: 365-403
Range on HMM: 46-92/350.0
NNKVKNRYRNILAYDHSRVMLEE--------VKGVPDSDYINASYIN
.   ||||.||| |.|||| |..         . .  .|||||.|..
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 361-406 2.4e-07 24.6 In-house 34-78 (244) alignment 
Range on Protein: 361-406
Range on HMM: 34-78/244.0
ASLPNNKVKNRYRNILAYDHSRVMLEEVKGvPDSDYINASYINGIE
| |  | .|||| ||| .|..||.|   |    ||||||.||.| .
avlsanatknryinilpfdetrvilssskk.egsdyinanyiqgsq
subfamily_CDKN3_pd Subfamily CDKN3 411-507 3.4e-07 24.0 In-house 101-190 (202) alignment 
Range on Protein: 411-507
Range on HMM: 101-190/202.0
KQYHYqGWPDKGVPKFAGpVLKMIQDVNESQeKAGNGpLLVHCSAGAGRTGVIIAVDSILreakRSDQIDIFSFINSMRNNRP-QMVQTPEQYAFVHE
  .||   .| .||. |   ||...... .  ||...  ||||  | ||. ..||   ..     .|.|.    |...|. .  . .||  || ...|
ivhhy.piadglvpdias.clkileelrinl.kayrk.tlvhcygglgrsslviacllly....lddtiepkdaidklrdlkgsraiqtvkqynylse
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 557-754 4.1e-07 23.7 In-house 92-282 (302) alignment 
Range on Protein: 557-754
Range on HMM: 92-282/302.0
FIATQMPLDSTV---LDFWRLVHDYHISTIIMLNQLNDK--TCSIYWPVNT-RSVTFGPFTVGHKGSENMNRVK-VRTLELKyKEEVHEIRQFEVQTWPT
 | .|.|  ...    .|||.|.. .| .. .| . ..   | | ..| ..   ...| . |  .  |...  |   ..|.   |.. .    .|.    
iilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvl.Pegcsnsvlanvyvltn

WIQSDGVQSQEQCMDAVLQLmdylhkceiqrsTEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLC
| |. . ... . . .. ..             ... ..|  ....    |.   |.| |..  .|.|... .  . . .. .|  ||. | .|. |   
Wkqkkvpvkyaeliktaakv............fakkikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsl

YKLLT
|  | 
yiall
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 366-404 9.5e-07 22.9 In-house 38-75 (287) alignment 
Range on Protein: 366-404
Range on HMM: 38-75/287.0
NKVKNRYRNILAYDHSRVMLEEvKGVPDSDYINASYING
.  |||| ..| .|..||.| . .|   |||||| |. .
avkknryadvlPiddtrvllsa.egelGsdyinanyvas
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 694-752 1.4e-06 22.6 In-house 2-60 (69) alignment 
Range on Protein: 694-752
Range on HMM: 2-60/69.0
LVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKL
.||| ||   .| | ..|  . ..  .  .|.| |.. .|  ||  |    .|.. .  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 355-404 1.5e-06 22.3 In-house 22-67 (283) alignment 
Range on Protein: 355-404
Range on HMM: 22-67/283.0
SQPSQIASLPNNKVKNRYRNILAYDHSRVMLEEVKGvpdsDYINASYING
.....|||  .|| |||...|...|  || |.        |||||..|  
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 540-648 1.5e-06 22.6 In-house 12-122 (130) alignment 
Range on Protein: 540-648
Range on HMM: 12-122/130.0
DKSPLQQEFEGYSKKN-AFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKtcSIYWPVNTRSV-TFGPFTVGHKGSENMNRVKVRTLELKYK--EE
..  ....| | . .   .. || ||  | .|||... . ..  ...|  ....    |||            .|     .... .|   || . .  | 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..deywpdsePlewyeediivtltdrdefknikasnleiesdlnes

VHEIRQFEVQTWP
 . .  |..  ||
hqaltmfqisnwp
TMEM51 Transmembrane protein 51 206-289 2.3e-06 14.8 Pfam-A 58-143 (233) alignment 
Range on Protein: 206-289
Range on HMM: 58-143/233.0
IIIPVVIVICIIIIILIMVTIGVQRRKRRKMYHN---RRERIVLETQAMNDYNDEQQAENHNEAYEEKTYLTAAGDETdSKMNKEKK
  . .|.| . ....|. . ..| ...||.  ..   ...  .|...  .. ..|..||.....|.  .|  . | .. |.......
ssvAyVLvgaGvalLlLsicLsvRnkrrrrqgeervqeeaaaellaseekeqeeeeaaeeaasrysvPsyeevvgsge.sevrqsel
DUF4448 Protein of unknown function (DUF4448) 154-230 2.4e-06 15.8 Pfam-A 112-186 (189) alignment 
Range on Protein: 154-230
Range on HMM: 112-186/189.0
RE--------GeggegpKGPTSQPVTLPALMTTVPTSEASTTTAS--GVTlalptnDQVLLYIIIPVVIVICIIIIILIMVTIGVQR
..               |||| . .. . |  . ....||   ..  | .      . . |.|..|||.|.......|....   .|
pdneefaedsl......kGptVsltskkdlkkkeksekasnnkseeegsd......ekyalaialPvvvvvaalgvllfllinrkkr
subfamily_VSP_pd Subfamily VSP 420-506 2.5e-06 21.6 In-house 103-192 (212) alignment 
Range on Protein: 420-506
Range on HMM: 103-192/212.0
DKGVPKFAgPVLKMIQDVNESQEKAGNGPLLVHCSAGAGRTGVIIAVDSILREAKRS--DQIDIFS--FINSMRNNRPQMVQTPEQYAFVH
|. |||.   .|.. ..|.|  ||  .  | .||  | |||| |.    .  |. ..  . .| |.    .  .... | |||| |. .|.
dhnvpkle.ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvg
Shisa Wnt and FGF inhibitory regulator 194-312 2.6e-06 16.6 Pfam-A 65-178 (179) alignment 
Range on Protein: 194-312
Range on HMM: 65-178/179.0
LALPTNDQVlLY-IIIPVVIVICIIIIILIMVTIGV-QRRKRRKMYHNRRERIVL-ETQAMNDYNDEQQAENhNEAYEEKTYltAAGDETDSKMNkekkG
.. |..| .  .  .  .| .|.|...|. .. | .     . |.  ..|.  .   .. ..     |. .. .. | ....  .. .   ....     
frkpvedpt.kdlkvvlivsiilivvfivvliviftcskcvlekavrrqrpvvtsassttvqatplpqeesk.apsypqpqs..qgyetpppqga....q

KAPSHPLSAPPEVPGSCEAPPP
 |   .| .|.. ..  ..||.
aaapyslalpepyllqpsgppa
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 695-753 2.9e-06 21.5 In-house 2-60 (69) alignment 
Range on Protein: 695-753
Range on HMM: 2-60/69.0
VHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
||| ||   .| | ..|  . ..  .  .|.| |.. .|  ||  |    .|.. .  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
DAG1 Dystroglycan (Dystrophin-associated glycoprotein 1) 177-237 3.9e-06 13.5 Pfam-A 120-179 (290) alignment 
Range on Protein: 177-237
Range on HMM: 120-179/290.0
TTVPTSEASTTTASGVTlALPTNDQVLLYIIIPVVIVICIIIIILIMVTIGVQRRKRRKMY
 ..|.. |||...   .    ..|.| |. .|| |.|. |..|  |.. |  ..... |. 
eeiPsevasteapeeda.eksseddvylhtvipavvvaailliagiiamicyrkkrkGklt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 554-649 3.9e-06 20.6 In-house 136-232 (244) alignment 
Range on Protein: 554-649
Range on HMM: 136-232/244.0
KNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLNDKtcSIYWPVNTRSVTF-GPFTVGHKGSENMNRVKVRTLELKYK-EEVH-EIRQFEVQTWPT
   .| || ||  | .|||... . |.  ...|  ....    |||       .    ||     ...  .|   ||..   .| |  .  |..  ||.
taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee..deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps
subfamily_DSP23_pd Subfamily DSP23 429-507 4.9e-06 21.3 In-house 69-140 (148) alignment 
Range on Protein: 429-507
Range on HMM: 69-140/148.0
PVLKMIQDVNESQEKagNGPLLVHCSAGAGRTGVIIAVDSIlREAKrsdqIDIFSFINSMRNNRPQMVQTPEQYAFVHE
 | .... |.|..||  |  . |||  | |||| ..|   . .| |    .     |  .|. ||  |.| ||   |..
qvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylv.kerk....laaaeaiaevrrlrpgsvetveqeklvrd
SID-1_RNA_chan dsRNA-gated channel SID-1 203-278 7.6e-06 11.5 Pfam-A 116-191 (570) alignment 
Range on Protein: 203-278
Range on HMM: 116-191/570.0
LLYIIIPVVIVICIIIIILIMVTIGVQRRKRrKMYHNRRERIVLETQAMNDYNDEQ--QAENHNEAYEEKTyLTAAGD
   . ...|||............| . ..|. ..    .| |  | .. .  ...   . ...... ||.  ...| .
ykkatlaivivllsllllfvvlviaiikekk.elkavskeiissepsgseqramdlqekeseedssleeed.ilkaeq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 552-599 8.6e-06 19.3 In-house 104-154 (349) alignment 
Range on Protein: 552-599
Range on HMM: 104-154/349.0
SKKNAFIATQMPLDSTVLDFWRLVHDYHISTIIMLNQLND---KTCSIYWP
| .. .||||.|| ||| ||....    .  .. ||. ..   . | ||| 
svekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq