Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 34-245 | 1.7e-165 | 545.6 | In-house | 229-440 (440) | alignment | ||
Range on Protein: 34-245
Range on HMM: 229-440/440.0
MSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQTW
. ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw
PTWIQSDGVQSQEQCMDAVLQLMDYLRKCEIQRSSEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYL
||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyl
LCYKLLTHHHTL
||||||||||||
lcykllthhhtl
|
|||||||||
| 0046845 | (Phosphotyrosine protein) phosphatases II | 10-243 | 1.3e-57 | 190.7 | In-house | 41-274 (284) | alignment | ||
Range on Protein: 10-243
Range on HMM: 41-274/284.0
DRSRPYLMTPGDRAGSNNYINASFMSGY-----SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHK
|.|| .| ..... ....|||||...|| .|..|||||.||..|| ||||.|.......|.||..| .. |. ||| . ..|.|.||| .
dhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtll
GSENMNRVKVRTLELKY---KEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKceiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVM
|... ..||||||.. ..|......| . .|| .|| | |. .. . .. ..|.. ..|.||.||| |. .|.|....
seevkddytvrtleltnlgytgesrtvthfhytswp....dhgvppspedlleflrlvrellen...........lpgggpivVHCsaGvgRtGtfiald
NCLEQLNNDG---AIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
.||||...| .||.. .. || ||..| || |...|..| ..
llleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
|
|||||||||
| 0051299 | (Phosphotyrosine protein) phosphatases II | 10-241 | 2.4e-57 | 190.0 | In-house | 62-284 (288) | alignment | ||
Range on Protein: 10-241
Range on HMM: 62-284/288.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVnTRSVTFGPFTVGHKGSENM
|.|| .| .... ....|||||...|| .|..||||| ||..|| ||||.|.......|.||..| .. .| ||| |.|.|..|| . | .
dhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevl
NRVKVRTLELK------YKEEVHEIRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLRkceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNC
. ..|||||.. ...|......| . .|| .|| . |...| . .....|. .|.|..||| |. .|.|... .
ddytvrtlevtnldlldgdgesrtvthfhytnwp....dhgvpdspellldflrlvrkala.............sgggpvvVHCsaGvgRtgtfialdll
LEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
||||.. | .||.. .. || ||. |.|. |...|..| .
leqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
|
|||||||||
| 0050432 | (Phosphotyrosine protein) phosphatases II | 10-243 | 2.6e-57 | 189.9 | In-house | 81-299 (308) | alignment | ||
Range on Protein: 10-243
Range on HMM: 81-299/308.0
DRSRPYLmtpgdrAGSNNYINASFMSGY--SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN--TRSVTFGPFTVGHKG
|.|| .| ....|||||...|| ....||||| ||..|| ||||.|.......|.||..| . ..| ||| . |...|.||| ..
dhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtlls
SENMNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQSQeqcMDAVLQLMDYLRKCEiqrsseqsrpgDGPPILVHCLSGIEESGVFCTVMNCL
|... ..||||||.. ..|......| .|| .|| .. ....|......||. .|.||.||| |. .|.|... .|
eevlddytvrtleltnlgdgesrtvthfhytnWp....dhgvPps...peilldflelvrksl...........pggpivVHCsaGvGRtGtfialdlll
EQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
|||. .| .|||. .. || ||. |.|. ||..|..| ..
eqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
|
|||||||||
| subfamily_PTPRD_pd | Subfamily PTPRD | 10-243 | 2.8e-55 | 183.0 | In-house | 61-281 (564) | alignment | ||
Range on Protein: 10-243
Range on HMM: 61-281/564.0
DRSRPYLMTPGDRaGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTrSVTFGPFTVGHKGSENM
|.|| | . . .||||||. || |..|.|||| || .|. ||||.| ....|||.||..|..| |. ||| .. . |.| .|| . .|..
dhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel
NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQSQEqcmDAVLQLMDYLRKCEiQrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
. . .||..|| ..|..|.||| || . || . ..|.|.. |... . | ||.||| .|.. .|.|... .||...
adyeirtfklkkkkssesreVrqFhFtsWP....dhgvpesa...tslLdlirkvraln.e........pdagPivVhCSaGVGRTGtfividamlerik
NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
... .|..| ...|| |. | | . | ... . .
eektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
|
|||||||||
| 0036941 | (Phosphotyrosine protein) phosphatases II | 10-243 | 4.5e-55 | 182.4 | In-house | 52-277 (297) | alignment | ||
Range on Protein: 10-243
Range on HMM: 52-277/297.0
DRSRPYLmtpgdRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSEN
|..| .| ....|||||...||. |..||||| ||..|| ||||.|.......|.||..| . ..| ||| . |.|.|.||| .. |
dhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvev
--MNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCL
. ...||||... ..|......| . .|| .|| . ....| . .. ..|.. .|.|.|||| |. ||.|... .|
vllddytlrtlevtdtgngesrtvthfhytgwp....dhgvpespaslldfielvrkvlkll...........psggpvlVHCsaGvgRsgtfiaadlml
EQLN---NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
.||. | .|... .. || ||. |.|| |. .| .| ..
qqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 10-243 | 1.8e-54 | 180.5 | In-house | 56-276 (317) | alignment | ||
Range on Protein: 10-243
Range on HMM: 56-276/317.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVnTRSVTFGPFTVGHKGSENM
|.|| .| .| ...|||||...|...|..||||| ||..|| ||||.|.......|.||..| .. .| ||| ..|.|.||| ... | .
dhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeel
NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQSqeqCMDAVLQLMDYLRKCEiqrsseqSrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
. ...||||.. ...|......| .|| .|| . .| .|......|.. . ..| |.|||| |. .|.|... .||||.
agitlrtlevedlgdsesrtvthfhytgWp....dhgvpp...spdllldfleavreal.......e..dpggpvlVHCsaGvgRtGtfiaaylmleqle
NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
| .||.. .. || ||. |.|. | .|..| ...
keggvdveeavkelreqRpgavqtpeqyrflydalleyl
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 10-242 | 5.5e-54 | 179.0 | In-house | 69-288 (297) | alignment | ||
Range on Protein: 10-242
Range on HMM: 69-288/297.0
DRSRPYLMTPGDRAGSNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT--CSIYWPVNTRsvTFGPFTVGHKGSENM
|.|| .| ..... ...|||||...||.. ...||||| ||..|| ||||.|.......|.||..|... | ||| .. |.|.||| .. |
dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehl
NRVKVRTLELKYKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNN
. ..|||||.....|......| . || .|| | |...... .....|... ..| |.|||| |. .|.|.. .||||.
dgytvrtlevtnngesrtvthfqytgwp....dhgvppslellleflelvrealael...........pkggpvlVHCsaGvgRtGtfiaaylmleqlek
DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
| .||.. .. || ||. |.|. | .|..| ..
eggvdvleavkelreqRpgavqtpsqyrflydallel
|
|||||||||
| 0047943 | (Phosphotyrosine protein) phosphatases II | 10-241 | 6.1e-54 | 178.7 | In-house | 51-270 (273) | alignment | ||
Range on Protein: 10-241
Range on HMM: 51-270/273.0
DRSRPYLmtpgdRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTR--SVTFGPFTVGHKGSE
|.|| .| |...|||||...|| .|..|||||.||..|| ||||.|.......|.||..| .. .| ||| . |.|.|.||| ... |
dhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllsee
NMNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKCEIQrsseqsrpgdgPPILVHCLSGIEESGVFCTVMNCLE
. . ..||||||.. .|......| . .|| .|| | |.... . .....|... . .|..||| |. .|.|... .|.
tkddytvrtleltnlgtgesrtvthfhytgwp....dhgvppslesllefielvrkalealpsn...........gpvvVHCsaGvgRtgtfialdllld
QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
||. | .||.. ..||| ||. |.|. |...|..| .
qlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
|
|||||||||
| 0045450 | (Phosphotyrosine protein) phosphatases II | 10-241 | 2.9e-53 | 177.0 | In-house | 68-302 (307) | alignment | ||
Range on Protein: 10-241
Range on HMM: 68-302/307.0
DRSRPYLMTPGDRAGSNNYINASFM--------SGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRSVTFGPFTV
|..| .|...... ....|||||.. .|| .|..||||| ||..|| ||||.........|.||..| .. | ||| . ..|.|.|||
dhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftv
GHKGSENMNRVKVRTLELK---YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKceiqrsseqsrPGDGPPILVHCLSGIEESGVFC
.. | .. ..|||||.. ...|......| .|| .|| | |.. | . .....|.. ..| |.|||| |. .|.|.
tllseehldgytvrtlevtdldgtgesrtvthfhytgwp....dhgvppsfeelldfieevrkalee...........lpkggpvlVHCsaGvgRtGtfi
TVMNCLEQLNNDGA---IDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. .|.||...| .|... ..||| ||. |... | .|..| .
aaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 10-240 | 3.4e-53 | 175.8 | Pfam-A | 14-234 (235) | alignment | ||
Range on Protein: 10-240
Range on HMM: 14-234/235.0
DRSRPYLmtpGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWP-VNTRSVTFGPFTVGHK-GSE
|..| | .. |...||||....||..|..|||||.||.||. ||||.| ......|.||..|..| .|. ||| . .|.|.| ..| | ..
dktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekek
-NMNRVKVRTLELKYKEEV---HEIRQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLRKCEiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCL
..... .|.|||| |.| .|..|. ...|| . .. ...|.|.. ..| . . |..||| |.. .|.|.... .|
edekeytlrklelkkkkeesekrevkqlhytnWpdhg.......vpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldill
EQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|||.... .||.| .. || .||. | .|. | .||...
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 10-240 | 3.4e-53 | 175.8 | In-house | 14-234 (235) | alignment | ||
Range on Protein: 10-240
Range on HMM: 14-234/235.0
DRSRPYLmtpGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWP-VNTRSVTFGPFTVGHK-GSE
|..| | .. |...||||....||..|..|||||.||.||. ||||.| ......|.||..|..| .|. ||| . .|.|.| ..| | ..
dktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekek
-NMNRVKVRTLELKYKEEV---HEIRQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLRKCEiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCL
..... .|.|||| |.| .|..|. ...|| . .. ...|.|.. ..| . . |..||| |.. .|.|.... .|
edekeytlrklelkkkkeesekrevkqlhytnWpdhg.......vpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldill
EQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|||.... .||.| .. || .||. | .|. | .||...
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 11-241 | 1.9e-52 | 173.4 | In-house | 70-288 (298) | alignment | ||
Range on Protein: 11-241
Range on HMM: 70-288/298.0
RSRPYLMTPGdRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNtRSVTFGPFTVGHKGSENMN
|| | . .||||||...|...||||||| || .|| ||||.| .. |.||.||..|... ... ||| . .. |.| .|| . .|..
ssRvvLeked.adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefa
RVKVRTLELKYKE--EVHEIRQFEVQTWPtwiqSdgvQSQEQCMDAVLQLMDylrkcEIQRssEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNN
. ||.|... |. . .|.||... .|| . .. . . .||.|.. .... |.. |. |..|.| .|.. || |. . ||....
dlivrklkvskkkeekerevrqlhftsWp....d...kgvpenatsvldllr.....kvra..sqqqagnk.pvivqCsaGvgRsGtfiaidsvlervkk
DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. .|||| .. || .||. | | ..| .|.. .
eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
|
|||||||||
| subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 10-241 | 1.3e-51 | 170.7 | In-house | 61-286 (325) | alignment | ||
Range on Protein: 10-241
Range on HMM: 61-286/325.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN--DKTCSIYWPVN-TRSVTFGPFTVGHKGSENM
|.||. | | .| ..| .|||||.. . ||. |.|.|.|| .|. |.|||| |.| | ...||.|. .. |..||| . |.|||.. | . |..
dksrvvletkkd.dpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei
NRVKVRTLELKYKE--EVHEIRQFEVQTWPTWiqsdGVQSQEQCMDAVLQLMDYLRKCeIQRSSEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLN
| |..| . | ..||..|.|. ||| . .. ..|||.. . .. .. .. | |||||| .|. .||| .. |...
sdyvhrvldvkqvkkGetrsvkqfqlqswddm....Gvqkrpatlisilqlvkavser.vtantkast.....pilvhcsaGvGrtGvfislysalakvi
NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.. .|.|. .. || ||. | | | |.|. |.
eesrvdifgfvkklrkdrpsmvetvdqyiliyealve
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 10-241 | 3.2e-51 | 169.8 | In-house | 58-275 (278) | alignment | ||
Range on Protein: 10-241
Range on HMM: 58-275/278.0
DRSRPYLMTPgDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPvnTRSVTFGPFTVGHKGSENM
|.|| .| . ...|||||...||.....||||| ||..|| ||||.|......||.||..| .. .| ||| |.|.|.||| .. | .
dhsrvklsll.ggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehl
NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLrkceiqrsseqsRpGDGPPILVHCLSGIEESGVFCTVMNCLEQL
. ..|||||.. .. |....... || .|| | .. .| . .....| . .. |.|||| |. .|.|... .||||
ddytvrtlevtnlgdgesrtvthyhylgwp....dhgvpeslsllldflkavreal............e.dsngpvlVHCsaGvgRTGtfialyllleql
NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.. | .|... .. || ||. |.|. | .|..| .
ekeggvdleeavkelreqRpgavqtpsqyrflyealle
|
|||||||||
| DSPc_SM00195 | 10-240 | 3.3e-51 | 169.5 | In-house | 39-259 (263) | alignment | |||
Range on Protein: 10-240
Range on HMM: 39-259/263.0
DRSRPYLMTPGDRaGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSEN
|..| | .. .. ...||||....|..||...||||.||.||| ||||.| . ....|.||.. .. ..|. ||| . .. ||| ..| . |.
dhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevek
MN-RVKVRTLELKYKE--EVHEIRQFEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLRKCEIQRsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQ
.. ...|||||.... | ....|.....|| ||..... ||.|. ...|.. . .||.||| |.. .|.|.|. .|..
kkdeiilrtleltkegkeetrkvtqyqyknWpdh....gvpdstk...svlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiilsk
LNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|... .|.|. .. || .||. | ||. || .|. .
leeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
|
|||||||||
| PTPc_SM00194 | 10-240 | 3.3e-51 | 169.5 | In-house | 39-259 (263) | alignment | |||
Range on Protein: 10-240
Range on HMM: 39-259/263.0
DRSRPYLMTPGDRaGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSEN
|..| | .. .. ...||||....|..||...||||.||.||| ||||.| . ....|.||.. .. ..|. ||| . .. ||| ..| . |.
dhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevek
MN-RVKVRTLELKYKE--EVHEIRQFEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLRKCEIQRsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQ
.. ...|||||.... | ....|.....|| ||..... ||.|. ...|.. . .||.||| |.. .|.|.|. .|..
kkdeiilrtleltkegkeetrkvtqyqyknWpdh....gvpdstk...svlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiilsk
LNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|... .|.|. .. || .||. | ||. || .|. .
leeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
|
|||||||||
| subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 9-242 | 1.3e-50 | 167.3 | In-house | 58-282 (305) | alignment | ||
Range on Protein: 9-242
Range on HMM: 58-282/305.0
EDRSRPYlMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ---LNDKTCSIYWPVNTRS-VTFGPFTVGHKGSE
| .| .|. . . ..|||||.. ||..|...|..| ||..|| |||||. ....|||.|| . ... | ||| ... . ||.|.| | ..
ldddrii.ltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek
NMNRVKVRTLELKY---KEEVHEIRQFEVQTWPtwiqSDGVQSQeqcMDAVLQLMDYLRKceiqrsseQSRPGDGPPILVHCLSGIEESGVFCTVMNCLE
... | |.. ..| . . |... .|| .|| . ..|.|.. ..| . . . | |.|||| |. .|||..| ||
tasdyieRklkisiededkesrtvlqyqltdWP....dhGvpqf...atsllslikrvqk........dqkkdkgvpllVhCsagvgRtGvfiavdiale
QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
.|.... .|||. |. || .|.. | || | .. |
rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 10-241 | 3.8e-50 | 166.2 | In-house | 24-244 (249) | alignment | ||
Range on Protein: 10-241
Range on HMM: 24-244/249.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENM
|.||..| .. ..|||||...|| |..||||| ||..|| ||||......|..|.||..| ..| ||| |...| ||| . | .
dhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevk
NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQL
. ..||||||. |. |....... . || .|| | |...| . .....|... ..| |.|||| |. .|.|.. .||||
ddytvrtleltnlydgesrtvlhiqytdwp....dhgvppsfedlldfieavrkaleel...........pkggpvlVHCsaGvgRtGtfiaaylmleql
NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. . .|... ..||| ||. |... | .|..| .
ekelgvdleeavkllrsqRpgavqnpeqyrflyealle
|
|||||||||
| subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 8-240 | 6.2e-50 | 164.9 | In-house | 60-276 (315) | alignment | ||
Range on Protein: 8-240
Range on HMM: 60-276/315.0
KEDRSRPYL-MTPGDRagSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNtrSVTFGPFTVGHKGS
|.||..| .. | .|.||.|. ||.||. .||.| |. ..| ||||||... |..|.||..| . . . ||| . |..|..|| .|
aydksrvqlpllendp..hsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkse
ENMNRVKVRTLELKYKEEVHEIRQFEVQTWPTwiqsDGVqsqeqCmDAVLQLMDYLRKCEIQRSSEQsrpgdgPPILVHCLSGIEESGVFCTVMNCLEQL
| ... |||| ......|. |... .||. || . . ||.. |. . .. .|.||| .|. .| |.|. |.|.
evnteytvrtlsvvfgdnirevvqlhytswpd....mgv.....p.kytiplmnlirtvkqhhtnsv......gaivvhcsaGvGrtGtfitldavldqa
NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
. . ||||.. .. .| | . | .. | . |. |
eaenaidvynfitgvrqnrikmvqvaeqyqfiydall
|
|||||||||
| subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 25-242 | 8.6e-49 | 161.0 | In-house | 36-241 (250) | alignment | ||
Range on Protein: 25-242
Range on HMM: 36-241/250.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN--DKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV
.||||||. ||....|||||| || .|. ||||.| .. ..||.||..|. .||.. ||||.. . ..| || . .|.. ...|.| | ...
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek.aekyGdvtvsllskeefadytkrklklskakka
HE--IRQFEVQTWPtwiqsDgvQSQEQCMDAVLQLMDylrkcEIQRSSEQSrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
.| .||.. .|| | .. . . |||.|.. ..|.| .|. . |..|.| .|. || |... ||.|... .|||. .. ||
derivrqlhfvvWP.....d..kgvPevatavLellk.....kvqasqqqa...gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrk
SRPNFVPTLTDYLLCYKLLTHH
||. | .|. | .|... .
drphavesleqyvfvyeiilka
|
|||||||||
| subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 16-240 | 2.1e-48 | 159.9 | In-house | 65-276 (288) | alignment | ||
Range on Protein: 16-240
Range on HMM: 65-276/288.0
LMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVR
.. .. ...|||||.. |. ||...|||| || .|| |||.||.....|||.||..| ....| ||| . . . .| .|| ..|.... . .|
klkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlr
TLELKYKEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdavlQLMDYLRKCEIQRSSEqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVF
.|.|. |.. || |.. ..|| .|| ... .|...||. ... ... ||.||| |. .|.| .. . ....... |||.
klllekkkteleitqyqylaWp....dhgvPeska......pllellrqvkvanqad......tgpiivhCsaGvGrtgtFialdalidaveeedyiDva
QNLRLLRLSRPNFVPTLTDYLLCYKLLT
. || .|...| ||. | .|. |
gtvaklRkqRallvqtlkqYefiyevll
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 10-242 | 4.6e-47 | 156.1 | In-house | 37-271 (278) | alignment | ||
Range on Protein: 10-242
Range on HMM: 37-271/278.0
DR---------SRPYlmtpgdragsnNYINASFMSGYskKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPvNTRSVTFGPFT
.| || . .|||||...|| ...||||| ||.||| ||||......|..|.||..| .. | ||| . |.|.|.||
nRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggsltygdft
VGHKGSENMNRVKVRTLELK------YKEEVHEIRQFEVQTWPtwiqSDGVQSQE--QCM-DAVLQLMDYLRKCEIQRSSEQSRPGDGPPILVHCLSGIE
| . |... . .|||.. . | ...... .|| || |.. . . ... .. ..|.. . .|. . ..| |.|||| |.
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwp....dhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg
ESGVFCTVMNCLEQLnnDGAIDVFQNLRLLRLSRPN-FVPTLTDYLLCYKLLTHH
.|... .. .||.| .| .|... .. || ||. |..| | .|..| ..
RtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
|
|||||||||
| subfamily_PTPRK_pd | Subfamily PTPRK | 9-239 | 5.6e-47 | 155.1 | In-house | 55-273 (314) | alignment | ||
Range on Protein: 9-239
Range on HMM: 55-273/314.0
EDRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVNTRSvtFGPFTVGHKGSEN
||||. |.| . |..||||... .| . .|||.|| ||..|| ||||||.|.. ..|.||..| ... |. ||| .|. .|.. | .|
ydrsrvflitidg.dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetel
MNRVKVRTLELKY----KEEVHEIRQFEVQTWPTWiqsdGVQSQEQcmdAVLQLmdyLRKCEIQRSSeqsrpGDGpPILVHCLSGIEESGVFCTVMNCLE
. . ||.. .. .||..|.|||. .||.. .| ... ..|.| .|. . .. ..| .|.|||..| .|.|... |.
laelvvrifrveklargqeeirevrqfqflgWpdh....dvPvsat...gllkl...vrrvkksqee.....eaG.rivvhCsaGaGrtGtfiaidivld
QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
....| .|||. . || ...|.| | | ..| .
mieregvvdvfnavktlrsrkvnmveteeqykfiydvi
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 10-239 | 1.4e-46 | 154.2 | In-house | 22-239 (245) | alignment | ||
Range on Protein: 10-239
Range on HMM: 22-239/245.0
DRSRPYLMTPGDRAGsNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENM
|..| .|. .| . . ..|||||...|| .. ||||| ||..|| ||||......|.||.||... . ..| ||| |.|.| ||| .. |..
dhtrvklspdggdld.sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehl
NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQSQEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
. ..|||||.. .. |..|.... || .|| . . .. .|.... .. ... |.|||| |. .|.|... .||||.
ddytvrtlevtnlgddesrevihyhylpwp....dhgvpdllellldflefvrkalae...........dsngpvlVHCsaGvgRtGtfiaaylmleqle
NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
. ..... .. || ||. |.|. | .|..|
kelgvsleeavkelrsqRpgavqtpsqyrflyeal
|
|||||||||
| subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 10-251 | 2e-46 | 153.5 | In-house | 61-291 (319) | alignment | ||
Range on Protein: 10-251
Range on HMM: 61-291/319.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNtRSVTFGPFTVGHKGSENM
||.| |.. . . .||||||. || ....||||| ||. |. ||||.| ....|...||..|..| .. ||| . ...| ..| . |..
drtrvvlseldg.vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeel
NRVKVRTLELKYKEE-V--HEIRQFEVQTWPtwiqSDGVQSQeqcmdaVLQLMDYLRKceIQRSSEQsrPGDGpPILVHCLSGIEESGVFCTVMNCLEQL
. . .| |.|. | . | |. .| . || ..| . ..|.| |.. |..| |. . .| || ||| |. | |... ||..
edyiirklklnkkssevetRevkhfqyteWp....dhdvPek......atslldllkr..irksrek..tqsg.PivvhCsaGvGRtGtfivldamlerv
NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTLCRSEEE
...|..|||. . ||. |. | . | ..|. | . . .| |
keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie
|
|||||||||
| subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 10-242 | 1.9e-44 | 147.0 | In-house | 59-279 (318) | alignment | ||
Range on Protein: 10-242
Range on HMM: 59-279/318.0
DRSRPYLMTPGDRAGSnNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPvNTRSVTFGPFTVGHKGSENM
|..| | . . || .||||... || .|.|.||.| || |. ||||.| . ..|.|| |.... . ||| . | ..| .| | . ..
dhtrvkLqmlegeegs.DyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevel
NRVKVRTLELKYKE--EVHEIRQFEVQTWPtwiqSDGVQSQEqcmdavLQLMDYLRKCEiqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLN
. .|..... .| |. ..||... .|| || .. .|.| .|. . . | ..| | ||.||| .|. |||..| ||...
sdyvlrefkvtrteeeesrqvrqyhytsWp....degvpesg......aslldlvrqvs....kaqqksgag.pivvhCsaGvGrtGvfiavdillerik
NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
... .|||| . || |. | | | ..|. |.
aealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
|
|||||||||
| subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 10-240 | 2.8e-44 | 146.4 | In-house | 64-281 (297) | alignment | ||
Range on Protein: 10-240
Range on HMM: 64-281/297.0
DRSRPYLMTPGDRAGSnNYINASFMSGYSKknAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN--DKTCSIYWPVNTrSVTFGPFTVGHKGSENMN
|.|| | .| | .|.||||. |. . .|.|||| ..|| |||..| |...|||.|||..| || | ||. .. ..||| .| . .. .
dssRvkLaivnddpds.Dyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg.vttfGdvsvvllsvsere
RVKVRTLELKYKE--EVHEIRQFEVQTWPTwiqsdGVQSQEQCMDAVLQLMDylrkcEIQRSSEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNN
|.||.. . . ..|.. ||. . ... . ..|.|.. |.. . .| | |.|||||.|. ||..|. ... . ..
GfikrelevtkgkakarrvvkqyqfveWPd.....kaverkdsassllklis.....evrkdfsqnaeg...PllvhclaGvGrtgvlltidsvvaeakr
DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
. ..|.|. .. || .||..| | .| . |...
ekevdifglvkklrqerpylvqtkeqykfvyvavl
|
|||||||||
| subfamily_PTPRA_pd | Subfamily PTPRA | 21-250 | 4.4e-44 | 145.7 | In-house | 81-302 (330) | alignment | ||
Range on Protein: 21-250
Range on HMM: 81-302/330.0
DRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELK
. . .||||||. || .|. |||.| |.. || ||||.. ... .||.|| .|.. . | ||| . .||.| .| . .. .. . || . ..
eGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvq
------YKEEVHEIRQFEVQTWPTWiqsdGVQSQEQCMdavLQLMDYLRKCEIQRsseqsrpGDgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
.... .||| ..|| || .. . | |.|. ..|.. | .. || ||| .|. .| |... . ||... .. .||
qlpdatrekksrlvrqfhftswPdv....GvPfepiGm...lkllkkvkklnqqs.......ag..pivvhcsaGvGrtGtfivldavlervkaerkvdv
FQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTLCRSEE
|. .. ||| ||. | |. | ..|| | ... .|
fefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
|
|||||||||
| subfamily_PTPRG_pd | Subfamily PTPRG | 10-241 | 4.7e-44 | 145.5 | In-house | 60-285 (563) | alignment | ||
Range on Protein: 10-241
Range on HMM: 60-285/563.0
DRSRPYLMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENM
|||| | . .. .||||... || |..|||||| || .|. ||||.. . . ..|.|. .|.. . | .||| |.|.| ..| . .| .
drsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevl
NRVKVRTLELKY-----K---EEVHEIRQFEVQTWPTWIQSDgvqSQeqcmdaVLQLmDYLRKCeiqrssEQSRPGDGPPILVHCLSGIEESGVFCTVMN
|||| .| | ......||.. .|| . .. . .| . .| ..... . ||.||| .|. ..|... .
alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe...hs......lpvL.ifvkks......saankaeaGPivvHcsaGvgrtGtyivldt
CLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
|.|.... |..||. |. .|. |.. | | .|. .. |
llkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
|
|||||||||
| subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 18-240 | 6.6e-44 | 144.9 | In-house | 68-280 (290) | alignment | ||
Range on Protein: 18-240
Range on HMM: 68-280/290.0
TPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRSVtFGPFTVGHKGSENMNRVKVRTL
.|.. .|.||||... ||..|...|||| |. .|. |||.|. . ... |.|| . . ..| ||| . . .|.|.. |..|. |.|
isghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierkl
ELKYKEE---VHEIRQFEVQTWPtwiqSDGVQSQEQCMDAVLQlmdylRKCEIQRsseqsRPGdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
|.| |.. ... |.....|. |.| ..| . |.. . ..|| ..| .|.||| .. |.|||.... ... . .| |||
evknknsagakqsvtqyqitnwd....stgkvtnpqtillvie.....emyktqr.....krg.ntsivvHCSdtvgrsavfcaaattinkcktegvidv
FQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|| |. .| .|. | | | . ....
fqvlksqRiqkpgsvqtvqqyqgifqivl
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 12-240 | 1.3e-43 | 144.2 | In-house | 57-287 (297) | alignment | ||
Range on Protein: 12-240
Range on HMM: 57-287/297.0
SRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGHKGSENMN
.| | . . .||||.|. || .|.|||||| ||. || ||||.| . .. .|.| .. .. |. ||| . | || ..| . |...
trvvlakvde.deasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeee
RVKVRTLELK--YKEEVHEIRQFEVQTWPTWiqsdGVQSQEQCMDAVLQLMDYLRKCEIQRSSEQ-SRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
|||.||.| .|| .. | . .|| . || |. . . ||. . . . .. ... . .||||.||| .|| .| |.|. ||..|.
dykvrvleiknvkteesrkvthfqflsWPdy....GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle
NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
. | .||.. ..||| | . | | .||. .
evgtvdvvetvkllrtqrafsiqtpeqyefcylavl
|
|||||||||
| subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 23-239 | 1.3e-43 | 144.1 | In-house | 69-273 (315) | alignment | ||
Range on Protein: 23-239
Range on HMM: 69-273/315.0
AGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDK-TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELKY
..|||||.. .. . .|.||.|.||...| ||||.| .....||.|.... .|| | ||| .. || || . | | .| | ..
sPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk
KEEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdavlQLMDYLRKCEiqRSSEQsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
|| . . ||. . || ||. | |. .... . .. . ..||||..|. .||.........|... ..|||. .. |
seesrtvtqfqftewPd....kGvdkqts......sllklikevk..adngk....kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknl
RLSRPNFVPTLTDYLLCYKLL
| || .| | .| . | .
rakrpylvqteeeyafiydav
|
|||||||||
| subfamily_CG7180_pd | Subfamily CG7180 | 10-246 | 2.1e-43 | 143.0 | In-house | 55-292 (296) | alignment | ||
Range on Protein: 10-246
Range on HMM: 55-292/296.0
DRSRPYLMTPGDRAGSNnYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK--TCSIYWPVNTrSVTFGPFTVGHKGSENMN
| |..| . . . |. ||||... .. ||...| |..| ..|| .|||||.| ||....| . | . ||| .. .|.. | ....
DynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqygeifveiveekqya
RVKVRTLELKYK----EEVHEIRQFEVQTWpTWIQSDGVQSQEQCMDAVLQLMDYLRKCEIQRSSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQL
.| ||. |. | | .. . |. . . .| ...... |.. .|. .. | . .| | |..|.. | |||.... .||..
nlkirtfkltkkivalteqekqvkaetRiv.klfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg.PvvvvssdGasRsGvylaidanlelv
NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHhTLC
.... .|||. .. || |||. | . ..| .| .| .. ||
ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea.vlc
|
|||||||||
| subfamily_PTPRB_pd | Subfamily PTPRB | 10-240 | 5.7e-43 | 142.0 | In-house | 64-282 (293) | alignment | ||
Range on Protein: 10-240
Range on HMM: 64-282/293.0
DRSRPYLMTPGDRAGsNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENM
| || |.. |..| ..||||....||. .. ||||| || .|| ||||.|.. . |.|.|| || .| | ||| ....|..| .| . .|..
dhsrvkLaalkdesg.sDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel
NRVKVRTLELKYKEEVHEIRQFEVQTWPTWiqsdGVQSQEQCMdavLQLMDYLRKCeIQRSSEQSrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNND
. .|.|... ..| ...||.. ..|| . || .. . . |... .|. |....... ||.||| .|. .|.| .. . |......
edwvirelkiekekeerkvrqyhftsWpdh....gvPektktl...ldfvrtvrea.iektaskr......PivvhCsaGvGRtGtfialdrllqaieee
GAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
.|.| . || .| ..| | ..|. .. .
dyvdifgivaelReeRnllvqtekqYifihqcvl
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 10-241 | 1.5e-42 | 141.2 | In-house | 23-240 (243) | alignment | ||
Range on Protein: 10-241
Range on HMM: 23-240/243.0
DRSRPYLmtpgdrAGsNNYINASFMSGYSKknaFIATQMPLDSTVLD----FWRLVHDYRISTIIMLNQLN---DKTCSIYWPvntRSVTFGPFTVGHKG
|.|| .| | ..||||... .. . .||||.||..|| | |||......|..|.||..| . | ||| .||.|.||| ..
dhsrvkl......eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtlls
SENMNRVKVRTLELKY---KEEVHEIRQFEVQTWPtwiQSDGVQSQEQCMDAVLQLMDYLRKCEiqrssEQSRPGDGPPILVHCLSGIEESGVFCTVMNC
.|... ..||||.|.. .......... || . .| |...| . .. ...... .| |.|||| |. .|.... .
eehlddytvrtlllenldlddltrlvihyhylpwp...dhgvPdspedlldfldevrefieell.....sllaldsggpvlVHCsaGvgRtGtliaaylm
LEQLnndGaIDVFQNLRLLRLSRPN-FVPTLTDYLLCYKLLTH
|..| | .|... ..||| ||. |.|. | .|..| .
llll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
|
|||||||||
| subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 25-239 | 8.7e-42 | 137.9 | In-house | 70-272 (515) | alignment | ||
Range on Protein: 25-239
Range on HMM: 70-272/515.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDKT-CSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE
..|.|||.. .. .|.||.|.|....| |||||| .....||.|...| .|| |. ||| . || || . | | |.|.. .
hsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgd
EVHEIRQFEVQTWPtwiqSDGVQSQeqcmdaVLQLMDYLRkcEIQRSSEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
... . ||. . || ||. . |. ... |.. . .| |...||..|. ||........ . .. ..|||. .. .|
dsrtvtqfhfteWP....dkGvpkh......tssllklik..evkadhgqyt....hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirq
SRPNFVPTLTDYLLCYKLL
|| .| | .| . | .
krpylvqtqeqyafiygav
|
|||||||||
| subfamily_Ptp69D_pd | Subfamily Ptp69D | 24-252 | 1.8e-41 | 137.3 | In-house | 74-295 (307) | alignment | ||
Range on Protein: 24-252
Range on HMM: 74-295/307.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE
. .||||||. || .|. ||| | |...|. ||||.. . . .|.|| .|.. | |. |||.. | .| | .|... |.|.. |.
edsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkk
-------EVHEIRQFEVQTWPtwiqsDGVqsQEQCMDAVLQLMDYLRKCEIQRsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
. ... |.. ..|. | .. ..|.|.. .|. . . ||.||| | ..||.| .. |.||... .|.|.
eesgevedsrkvvqyhytgWk.....Dsk..vPevargllklieqvrelykln.........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife
NLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTLCRSEEEL
. || |. .| | | .|. | ... ..|..
tvkdLrsqRnllvqsleqYvflyralldyssygdtdedv
|
|||||||||
| subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 25-249 | 5.6e-41 | 135.9 | In-house | 88-297 (319) | alignment | ||
Range on Protein: 25-249
Range on HMM: 88-297/319.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNqlnDKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEE
.||||||..|| .|. .||.| ||| |. ||||.. .|..|||..| . || ||| .. .. . | | . |. . || .|| ...
fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekd
VHEIRQFEVQTWPTWIQSDgvqsqeqcmdAVLQLMDYLRKCEIQRSSEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLS
. .|.|| . || . | .|| ..| . .| |. | .|.||| .|. .||. .. |...... .||.. .| ||
irkitqfhflGwpdvGvpd..........ypsdlmrlvkkvrhltskenhr....anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqq
RPNFVPTLTDYLLCYKLLTHHHTLCRSE
|...| |..| ..| | .| . .|.
rntlvqdlvqykfiysalleehlfghsd
|
|||||||||
| subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 26-249 | 6.1e-41 | 135.8 | In-house | 53-261 (284) | alignment | ||
Range on Protein: 26-249
Range on HMM: 53-261/284.0
NNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNqlnDKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEEV
.||||||..|| .|. .|||| ||| |. ||||.. .|..|||..| .. || ||| .. .. . | | . |. . || .|| ....
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdi
HEIRQFEVQTWPTWIQSDgvqsqeqcmdAVLQLMDYLRKCEIQRSSEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSR
.|||| . || . | .|| ..| . .| |. | .|.||| .|. .||. .. |...... .||.. .| || |
rkirqfhflgwpdvgvpd..........ypsdlmrlvkkvrhltskenhr....anivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqr
PNFVPTLTDYLLCYKLLTHHHTLCRSE
...| |..| ..| | .| . .|.
ntlvqdlvqykfiysalleehlfghsd
|
|||||||||
| subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 23-241 | 7.6e-40 | 131.5 | In-house | 67-291 (301) | alignment | ||
Range on Protein: 23-241
Range on HMM: 67-291/301.0
AGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVR------
...|||||...|||.|..|||.| |...|. |||||. ... ..|.|. .|... | ||| ...| .|||||| . . .. .|
lcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki
-----------TLELKYKEEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdAVLQLMDYLrkceIQRsseQSRPGDGpPILVHCLSGIEESGVFCTVMNCLE
... | . . ... |..| ||. ||| . . ||| .| |.| | ..| | |..||| .. |||.|.| ||
qdgsnngyierkfkvksdksswdvlqlqvtdWpq....dGvvrepr...tvLqviddv....ihr...qqkiggg.pvvVHCSdtVsrsGvYcsvsiglE
QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
| .| .|||| . .| |.| | || | |. ..
QckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
|
|||||||||
| subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 25-238 | 9.2e-40 | 131.4 | In-house | 70-273 (287) | alignment | ||
Range on Protein: 25-238
Range on HMM: 70-273/287.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPvNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE-
..||||.|. ||..|.|||... |. .|. .||.|..| ....|.|| |... . | ||| ...||..|.... | .. . .|.||.| |.
hpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp.eeksvvlGeyniellneevnagyierklevknknk
--EVHEIRQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDylrkceiQRSSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
. ....|... .|. | | .. | ..| ... .. .| ..|.. .|.||| .. |..|| . ... ...|.||||| |.
agdkqqvkqyqitnWd....stgkvtepq...tillvie.......emyktqrkrgnt.sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksq
RLSRPNFVPTLTDYLLCYKL
| .|. | | . | ...
riqkpgsvqtveqykfindi
|
|||||||||
| subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 10-243 | 8.6e-39 | 128.3 | In-house | 41-268 (274) | alignment | ||
Range on Protein: 10-243
Range on HMM: 41-268/274.0
DRSRPYLMTPGDRAGSNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTRS---VTFGPFTVGHKG
..|| | . .. .|||| .. ||.. ..|..||| || .|| ||||... ... |.|| .|.. . |. |.| .. ..| . . ..
ensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvek
SENMNRVKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVlqlmdylrkceiqRSSEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQ
. | .||.| ||| |. ... . || . | ... . .. | ..|.... |..||| .|| |.| .. ... |
iverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev.............eesreeenaklapvvvhCsaGiGrtGcfiaisiavrq
LNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
|.... .||.. ||| | | | | | .. |....
lreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
|
|||||||||
| subfamily_PTPN12_pd | Subfamily PTPN12 | 21-240 | 1.9e-38 | 127.0 | In-house | 63-274 (290) | alignment | ||
Range on Protein: 21-240
Range on HMM: 63-274/290.0
DRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ---LNDKTCSIYWPVN-TRSVTFGPFTVGHKGSENMN-RVKVRTLE
. ..||||.|. | ..| ..||.| || |. ||||.. ..... ..|. . |. | | ||| . ....||.|.| . .... .|||.
eeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLk
LKYKEEVHEIRQFEVQTWPTwiqsDGVQSQeqcMDAVLQLMDYLRKCEIqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNND---GAIDVF
.. ..| ....||. . || || |. .. .|.|.. .|. . . |..||| .|. |. ... |.|... .|||
veaqkesrkvyqfhYtaWPD....hgvPss...aksllelielvrelqe.........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf
QNLRLLRLSRPNFVPTLTDYLLCYKLLT
. .. || |. | | | | || ..
dlvlelrkqraalvqtkeqyelvykava
|
|||||||||
| subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 24-246 | 1.7e-37 | 123.8 | In-house | 55-268 (283) | alignment | ||
Range on Protein: 24-246
Range on HMM: 55-268/283.0
GSNNYINASFMS---GYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELK
|..||||.|. | ... .|..| ||| || |||..|.| .|..|.|| .| . . || ||| . |. .|.||| . | .. | |.
esrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllr
YK---EEVHEIRQFEVQTWptwiqsdgvqsQEQCMDAVLQLM-DYLRKCEIQRSSEQSrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
.. .. . . |. | | .|.. . . . |. |... ||.||| .|| ..||.... .... . .|||.
vnssakstlllahyqvidW...........leygeqaiinslvkfnkvislqteskkg......PivvhCstgiGrtavfiaasasvkdaltesvvdvfa
NLRLLRLSRPNFVPTLTDYLLCYKLLThHHTLC
.. .| |. | || | | ..| ..||
vvkimreqrmmavqtldqyklvhelvl.eqalc
|
|||||||||
| subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 25-242 | 4.7e-36 | 119.2 | In-house | 47-263 (270) | alignment | ||
Range on Protein: 25-242
Range on HMM: 47-263/270.0
SNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRS---VTFGPFTVGHKGSENMNRVKVRTLELK
.|||| .. |... |...||.. ||..|. .|||.. . . ..|.|. .|..| |. ||| .. . ...| .| .|... .. |.|.
ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle
YKEEVHEIRQFEVQTWPtwiqSDGVQSQEQCMDAVLQLMDYLRKceIQRSSEQSRPGDgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRL
.| | ... | .||| .|| ..|. ||. ||. ..||... . .. |.|||| |.. .|.. .. ... |.... .|| . ..
ekgeerrlvHfwyntWp....dhgvpreedsslstdqllkmlra..vrrsekeldkae..PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiiee
LRLSRPNFVPTLTDYLLCYKLLTHH
|| |...| . | . || ....
lRkdRmalvqhpeqyeflykavvey
|
|||||||||
| subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 24-243 | 7.3e-35 | 115.3 | In-house | 55-259 (267) | alignment | ||
Range on Protein: 24-243
Range on HMM: 55-259/267.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTCSIYWPVN-TRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEE-
..|||||.. || .|||||.|| ||. |. ||. ..||.....|..| . .|| . .. . .|| | .. | .. |||||.|.|
keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes
VHEIRQFEVQTWPtwiqsdgVQSQEQCmdAVLQLMDYLRKCEIQRsseqsrpGdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLS
|.. . . | ...... . |. | | ... | ..|..|.| |. || | .. ||.. ..| |.|. || .|
ahnvtlyyykkwn.......intnnkp..ylkplfgilaknqlen.......g.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsq
RPNFVPTLTDYLLCYKLLTHHH
|. .| |. |. ...||...
riglvdtkeryiyihellaeya
|
|||||||||
| subfamily_PTPN6_pd | Subfamily PTPN6 | 22-244 | 7.2e-34 | 112.2 | In-house | 77-298 (306) | alignment | ||
Range on Protein: 22-244
Range on HMM: 77-298/306.0
RAGSNNYINASFMSGY--SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLEL
..||||..... ......|||| |..|| ||||.| . |.|. . ... |. ||| .... ..| .| . ...... ..|.| .
svpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsv
---KYKEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDylrkcEIQRSSEQSRPGDGPPILVHCLSGIEESGVFCTV---MNCLEQLNNDGAID
| |.| .|..|.. ..|| ||... . |||.... ...| .|... . ||.||| .|| | | . .. .|. .| ||
skkkkkkeerevfqyhfksWP....dhgvpkdpg...avLdfle.....dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadid
VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHT
. . ...| | .| | . | . || ....
iqklvksvreqrsglvqteqqykfvykaikkyie
|
|||||||||
| subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 16-240 | 2.4e-33 | 110.5 | In-house | 59-273 (281) | alignment | ||
Range on Protein: 16-240
Range on HMM: 59-273/281.0
LMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVR
.|| ... ...||||.|..||......|||| |. ... .||..| ....|.|.|. . | ||| .. ....| .|| .. .|. .. |
kvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyier
TLEL-KYKEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdavlQLMDYLRkcEIQRSSEQSRPgdgPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAID
...| . . | |..|.. ..|| || .. . .|... . |... .|... |...|| .|. .|.. .. ....... .|
kfkleresgetreveqlaytaWP....dhGvPattk......ellefrk..evlkltekktk...aplvihCsaGvGrtGtyialDrlvkaveaeleeld
VFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
| . .. || .| .| |.. | || .
vkavvaelrkernlmvqtvvqyefvykavl
|
|||||||||
| subfamily_PTPN23_pd | Subfamily PTPN23 | 23-240 | 7.9e-33 | 108.5 | In-house | 64-277 (288) | alignment | ||
Range on Protein: 23-240
Range on HMM: 64-277/288.0
AGSNNYINASFMSGYSKK-NAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNT-RSVTFGPFTVGHKGSENMNRVKVRTLELK
. ..||||||. . | ||||| ||.||. |||..|.. . |.|.|| . ... .. ||| .. ..|.||...| | .... . |.|.|.
gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle
YKE--EVHEIRQFEVQTWPTWiqsdGVQSQEqcmDAVLQLMDYLRKC-EIQRSSE-QsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNN-DGAIDVF
.. .|.... ....|| || . . .||..| ... | .. . |..|||..|.. .|||. |. ...|.. .| .|.
tldadavksvshlqltsWpel....GvPasP...etllqfldevesayeavqrkskt.......PlvvhCsaGvgRtgvfalvyaavrelekgnglldii
QNLRLLRLSRPNFVPTLTDYLLCYKLLT
| .. || | . | . . . .|.
qvvsrlreqRrfmvqekeqlkfsyeavl
|
|||||||||
| subfamily_PTPN14_pd | Subfamily PTPN14 | 22-241 | 1.7e-32 | 107.6 | In-house | 72-294 (300) | alignment | ||
Range on Protein: 22-241
Range on HMM: 72-294/300.0
RAGSNNYINASFMSG--YSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--ND-KTCSIYWPVN---TRSVTFGPFTVGHKGSENMNRVKVRT
. |..||||| .. .|. .|..| ||. || |||..| . .. |.|| . . . . |.| . ..|.|| | | | ||. ..| ..
kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittg
LELKYKEEVHEIRQFEVQtWPTWiqsdgvqSQEQCMDAVLQLMDYLRKCEI-QRSSEQSRP--GDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAID
|.||. .| . .| . | ..... . | . ..||.. . .| ...... ||.||||. |. .|| .. .. |... ||
lklkhlpskeertvwhlq.ytDW.......pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid
VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. . |. || | .|.||. | ||.| .
ikkvlarLreqrmllvqtlaqYkfvYkvlik
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 26-241 | 9.9e-32 | 106.0 | In-house | 4-223 (272) | alignment | ||
Range on Protein: 26-241
Range on HMM: 4-223/272.0
NNYINASFMSGYSK---KNAFIATQMPLDSTVLDFWRLvHDYRISTIIMLNQLN---DKTCSIYWP-----------VNTRSVTFGPFTVGHKGSENMNR
..||||....|| . .........||. |. ||||| ....|.||..| ... |. ||| . ....| ..| . |...
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld
VKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQsqeqcmDAVLQLMDYLRKceiqrsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGA
. .|.|.|... .|.|.. . .. |. | .|.|.|...|.. | |.|||| .|. .|... . .|.... .
yilrellltlllsagearevmhlhytdwpdhgvpq......eallellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsleti
ID--------VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.| ... .. || ||..|.| . || .|. | .
vddYlltnlyleeaveelraqrpgavqteeqylflyealle
|
|||||||||
| subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 23-241 | 3.2e-31 | 103.2 | In-house | 63-276 (287) | alignment | ||
Range on Protein: 23-241
Range on HMM: 63-276/287.0
AGSnNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIML-NQLND--KTCSIYWPVNTRSVTFGPFTVGHKGSENMN-RVKVRTLELKY
|| .|||| ....| ...||||.| |. .|| ||||.| . | ...|.. .... . | ||| . . . | ..| .... ||.| |
lGs.dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid
KE--EVHEIRQFEVQTWPtwiqsDGVQSQeQCMDAVLQLMDYLRKCEIQRSSEQSrpgdGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
| | . ..|... .|| |.| . .. . .| .. |..|.... || ..||. || ||.. ... ....|.. | .|| . .
letrearvvkqldllswP.....dkvlaP.tavglirfvldvkqhielardasev....GP.lvvhddvGiGrsGillatlvlvsrledlGrvdvaavvi
LLRLSRPNFVPTLTDYLLCYKLLT-H
|| | .| . . | |. |. .
rlreyraalvqavvqlrllyealvty
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 13-241 | 1.2e-30 | 101.8 | In-house | 8-169 (182) | alignment | ||
Range on Protein: 13-241
Range on HMM: 8-169/182.0
RPYLMTPGDRagSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNqlndktCSIYWPvntrsvtfgpftvghkgsenmnrvkvr
. .|. . .| ..||||... |. . . ||||| ||.||| ||.|......|.||..|. . |||
sdilpydhsr..dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp...........................
tlelkyKEEVHEIRQFEVQTWPTWIQSDgvqsqeqcMDAVLQLMDYLRKceiqrsseqsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQlnndGaIDVF
... ... |. || . | .| .|.... .. .| |.|||| |. .|... .... | ....
......ellerlgiqylylpwpDhgvpd........ldelldfieevle.............eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsle
QNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. ..|.| ||. | |. | ... .| .
eavklvrsrRpgmvitpnqyfflqlalle
|
|||||||||
| subfamily_PTPN13_pd | Subfamily PTPN13 | 23-239 | 1.7e-29 | 97.9 | In-house | 57-265 (273) | alignment | ||
Range on Protein: 23-239
Range on HMM: 57-265/273.0
AGSNNYINASFMSGYSKKNAF--IATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSV-TF-GPFTVGHKGSENMNRVKVRTLE
.. .|||||.. |. . ||.| || || |||..| . . . |.|. . .| | |||..... . . ..| . .... .||.|.
gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvrala
LKYK--EEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdAVLQLMDYLRKceIQRSSEqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
.| . .|..|. ... .|| || |. . .||.. ..|. .|... ||.||| .|| ||.. |. |. ...| .|| .
vkdsesgesrevahlnfvkwPd....hgvPssaa...ellqfvaevrr..lqtdag........PivvhcsaGiGrsGtlitidvvlglierdkefdvke
NLRLLRLSRPNFVPTLTDYLLCYKLL
.| || | | | |...|| .
ivrklreqrqgvvqtkdqyifvykai
|
|||||||||
| subfamily_PTPN3_pd | Subfamily PTPN3 | 24-235 | 2.4e-29 | 97.1 | In-house | 63-268 (280) | alignment | ||
Range on Protein: 24-235
Range on HMM: 63-268/280.0
GSNNYINASFMS----GYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLEL
....||||.... . . | .|||| ||..|. |||..|.. ..|.|.|| .| .. | ||| .. ....| |.| . ... . . .| | |
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvl
KYKE--EVHEIRQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDYLRKCEiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQN
| || | ..| |. || || .... .|.... .||. |. |..||| .||. .||. .. .| ... .. . .
kdketkeerkilqlqylaWp....dhgvPddsa...dflefvervrklr.........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldi
LRLLRLSRPNFVPTLTDYLL-C
.| .| | ..|.| . | . |
vrtmrdqramlvqtasqykfvC
|
|||||||||
| subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 10-237 | 3.6e-29 | 96.7 | In-house | 16-233 (237) | alignment | ||
Range on Protein: 10-237
Range on HMM: 16-233/237.0
DRSRPYLMTPGDRagsNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNTRSVTFGPFTVGHKGSEN
| || | .| .||||... |. . .||.| ||.|. |||..| . . | |.|| | |.. | ||| . ..| .|| | |.
dhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkee
MNRVKVRTLELKYKEEVHEIRQFEVQTWPTWIqSDGVQSQeqcMDAVLQlmdyLRKCEIQRSSEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNN
. ||.| | .. ...|.| . .| || | |.|. .|| |.|| |. | | ..|| .|. .|.| . | | ..
fsdytvrslllskrltlkevrlihqyqftswp.drgvpqq...taallr....frkniinrsphvsesg...pwiihcsagvgrtgiflvidamlrqake
DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYK
.|... . . || . | .|.. ..
kkvvdiynyvysieedrpyiiqtkdqyvfihq
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 12-244 | 9.7e-28 | 93.2 | In-house | 60-281 (314) | alignment | ||
Range on Protein: 12-244
Range on HMM: 60-281/314.0
SRPYLmtPGDRAGSNNYINASFMSGYskkNAFIATQMPLDSTVLDF----------WRLV--HDYRISTIIM---------------------LNQLNDK
.| | || . .|||||...|. ..||||| ||. || || ||.| |... .| | |..| .
nrvil..pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgn
TcsiywpvntrsvtfgpftvGHKGSENMNRVKvrtlelkykeevheirqfEVQTWPTWIQSDGVQS--------QEQCMDAVLQLMDYLRKCeiQrsseq
. .. ... | |....| . . |.. .. . ........... .
g...................neptaadlellk..................eelydpelferlgikylripvpDgsaplledfdeflefieea..d.....
srpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNndgaIDVFQNLRLLRLSRP-----NFVPTLTDYLLCYKLLTHHHT
.| |.|||| .|. .|.|.... .. .|. ... . |. .|| || .|...| .|. ... | ..
....kggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 26-237 | 1.2e-26 | 88.9 | In-house | 2-164 (174) | alignment | ||
Range on Protein: 26-237
Range on HMM: 2-164/174.0
NNYINASFMSGYSKKNAFIATQMPLDstvldFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVntrsvtfgpftvghkgsenmnrvkvrtlelKYKEEV
..|||||..... . .||.| ||. ||.......|.|..||.... . | ||| ... ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle
HEIRQFEVQTWPTWIQSDGVQsQEQCMDAVLQLMdylrkceiqrsseqSRpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNnDGAIDVFQNLRLLRLSR
... |. || | . ......| . . |. ..| |.|||| |. .|... . .| .| ...|... .| ||| |
rlgiqylylpwpDhgvpdlsi.llefvkfveeal..............se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqr
PNFVPTLTDYLLCYK
|. |.| | .|.
pgmvqtpsQyrflyy
|
|||||||||
| subfamily_PTPN1_pd | Subfamily PTPN1 | 24-229 | 1.1e-25 | 84.9 | In-house | 54-257 (290) | alignment | ||
Range on Protein: 24-229
Range on HMM: 54-257/290.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTR--SVTFG--PFTVGHKGSENMNRVKVRTLEL
..|.|||||.. | .| || || .|| ||..| . . ...|||.. .| | ||| . . .... ..| |. . .||.|||
adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllel
KY--KEEVHEIRQFEVQTWPTWiqsdGVQSqeqCMDAvlqLMDYLRKCeiqRSSEQSRPGDGPPiLVHCLSGIEESGVFCTVMNCLEQLNNDGA---IDV
. .| .|| .| ||| . || . . | ....| |. |.| . ||. ..|| .|| || || | || .... . .|.
enlktqetreilhfhyttwpdf....gvpe...spaa...flkflfkv...resGslssdvGpa.vihcsaGiGrsGtfclvdtclvliekkddlssvdi
FQNLRLLRLSRPNFVPTL
. | || | .. |
kkvllelrkyrlGliqta
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 25-237 | 2e-25 | 84.9 | In-house | 4-155 (172) | alignment | ||
Range on Protein: 25-237
Range on HMM: 4-155/172.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelK--YKEEV
...|||||....| . . ||||| ||..|. ||||..... |..|..|..| .. ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpelle
HEIRQFEVQTWPtwiqSDGVQsQEQCMDAVLQLMDY--LRKCeiqrsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLeqlnndGAIDVFQNLRLLRL
... |. || ||. . .. .|...| ... | |.|||| |. .|... .| ..... ..|.|
rlgiqylylpwp....Dhgvp.llellleflefidellalsp.............ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvre
SRPNFVPTLTDYLLCYK
||. |.. | ..|.
kRpgavqnpsqyrflyy
|
|||||||||
| subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 25-238 | 5.1e-25 | 82.8 | In-house | 75-274 (439) | alignment | ||
Range on Protein: 25-238
Range on HMM: 75-274/439.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTCsiYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV--
|||| .. || ... .||||.| . |. |||||| . . .||.|| .| . ||| .. | .| .| .. . .| . . . .
hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdtte
--HEIRQFEVQTWPTwiqsDGVQSQEQcmdavlQLMDYLRKCEIQRSSEQSrpGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
. . || .|| | .| ..|.|| . .|. | |..||| .|. .| .. .||||. . .|. ...||
kertvlqfhyiawpd....knvpaqas......hvldflrainsandkeey..g...pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrk
SRPNFVPTLTDYLLCYKL
| ..| .| .|.. |.
qrkqmvqalcqyvfiyna
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 25-238 | 8.2e-25 | 82.3 | In-house | 58-290 (297) | alignment | ||
Range on Protein: 25-238
Range on HMM: 58-290/297.0
SNNYINASFMSGYS--KKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGH--KGSENMNRVKVRTLEL
..|||| .. .. .| .| ||..|| |||.|| . . .|.|. .|.. | ||| . . | . | . . |.. .||.. |.|
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelql
KYKEEVHEIRQFEVQTWPTWIQS----DGVQSQEQCM------DAVLQLMD-YLRKCEIQRSSEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNN
|..| .| . .|| | |. | | .| |.. . .| | .. ..|||| .|. ||| . |..| .
iyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrk
DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKL
. || |. || |. | || . |.|..
kripdvaailsilreqrarlvqtleqfellyda
|
|||||||||
| subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 24-239 | 1.7e-23 | 77.7 | In-house | 79-279 (290) | alignment | ||
Range on Protein: 24-239
Range on HMM: 79-279/290.0
GSNNYINASFMSGYskKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGS-ENMNRVKVRTLELKY
. .|. | .. | | || || .| .||.|.||.| . ....|.|| .| . |. |.| . . .||| .|| . .. .... .|| ..
ydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrd
KEE--VHEIRQFEVQTWPtwiqsDgvQSQEQCMDAVLQLMDYLRKCeiqrsseqsrPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
|.. | .. .....|| | .| . |.|... ||| .| |. ||| .|| .| | .. .|. | . ..|. . |
kdsGkehklkhlkikswp.....d..ksvalstlallrtlrilrka..........sG...pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvr
LLRLSRPNFVPTLTDYLLCYKLL
|| || | | ..||. ..|
alrnsrlnsvqvdiqylalveil
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 33-237 | 9.1e-22 | 72.8 | In-house | 1-144 (152) | alignment | ||
Range on Protein: 33-237
Range on HMM: 1-144/152.0
FMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfe
|..|| ....||||| |.. |. ||||..... |.||.||..| .. | |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................
vQTWPTWIQSDGVQSQEQCMDAVLQLMDYLrkceiQ---RSseqsrpgdgpPILVHCLSGIEESGVFCTVMNCLeqlnndGAIDVFQNLRLLRLSRPNFV
| ... .||.. .|... .|.... | . |.|||| |. .|... .| ..... ..|.| ||. |
.qylhlpwpDhgvpdlsqlllflllfiekl.....aldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgav
PTLTDYLLCYK
|. . ..|.
pnpgqlrflye
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 26-238 | 2.9e-21 | 71.1 | In-house | 3-148 (151) | alignment | ||
Range on Protein: 26-238
Range on HMM: 3-148/151.0
NNYINASFMSGYskknaFIATQMPLDstvlDFWRLVHDYRISTIIMLNQLN-DKTCSIYWPVNTrsvtfgpftvghkgsenmnrvkvrtlelkykeevHE
..|||.|.. |. ......||. ||..|.... |.||..|... ..| |.| . .|
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................ie
IRQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLRKceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQlnndgaIDVFQNLRLLRLSRPN
.... . ||. ... ||||.....|.. .. |.|||| .|. .|... .. .|.. ..... |. .||.||.
vlhipildwpdpg.......lplsfdavleflellld............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpg
FVPTLTDYLLCYKL
.| . . .|....
vvqpnqqflfqlfa
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 23-238 | 3.5e-21 | 71.2 | In-house | 9-168 (176) | alignment | ||
Range on Protein: 23-238
Range on HMM: 9-168/176.0
AGSNNYINASFMSGYskknAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVnT-RSVTfgpftvghkgsenmnrvkvrtlelky
.. .||||... |. ..|||| || .|. ||........|.....|... | |||. .
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi..........................
keevheirqfevQTWPTWIQSDGVQSQEQCMDAVLQLMDYLrkceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMncleQLNNDGAIDVFQNLRLL
| . . . || . |...... .. ..| .| |.|||| || .|... | . ..|.. |.|.
............qylhlpwpDhgvpdlelllellefireal..............keggpvlVHCsaGigRtgtlvaay....llelekglsveealalv
RLSRP-NFVPTLTDYLLCYKL
| || . |.| | .|.
reqRplgavqtpeQyrflyef
|
|||||||||
| subfamily_PTPRN_pd | Subfamily PTPRN | 24-237 | 1e-20 | 68.6 | In-house | 82-286 (297) | alignment | ||
Range on Protein: 24-237
Range on HMM: 82-286/297.0
GSNNYINASFMSGY-SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTrSVTFGPFTVgHKGSENM--NRVKVRTLELK
...|||||.. .. |.|||| || ||| |||..| . . |..| .|.. | |. ||| . | ... . | | || . . ||.. ||
eksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyev.hlvsehiwcddylvrsfylk
Y--KEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdavlQLMDYLRKCEiqrsseQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQN
..| . || .|| . || .. . |... || . .| | ||.||| .| .||.. . |..|.. ||.
nlqtsetrtvtqfhflswp....eegvPasak......sllefrrkvn......ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaat
LRLLRLSRPNFVPTLTDYLLCYK
| || ||..| | .. ....
lehlrdqrpglvktkdqfefalt
|
|||||||||
| subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 25-235 | 1.2e-19 | 65.4 | In-house | 34-232 (239) | alignment | ||
Range on Protein: 25-235
Range on HMM: 34-232/239.0
SNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKE
..|||||.. | .|.|||| . . ||||.. . | |.|| | | | ||| .| . . | . .| . .||. .
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvg
EV--HEIRQFEVQTWPtwiqSDGVQsqeQCMDAVLQLMdylRKceIqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
. . . |. . || || | ||| | || | ...| || | ..|| .|. .| | . | | ... ..|.|. .. .
qteeryvyqyhftvwp....dkgvp...qyatavlglr...rk..i...tkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkai
RLSRPNFVPTLTDYLLC
| || .| | .|..
redrphmvqtseqyvfi
|
|||||||||
| subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 25-235 | 1.3e-19 | 65.4 | In-house | 35-233 (239) | alignment | ||
Range on Protein: 25-235
Range on HMM: 35-233/239.0
SNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKE
..|||||.. | .|.|||| . . ||||.. . | |.|| | | | ||| .| . . | . .| . .||. .
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvg
EV--HEIRQFEVQTWPtwiqSDGVQsqeQCMDAVLQLMdylRKceIqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
. . . |. . || || | ||| | || | ...| || | ..|| .|. .| | . | | ... ..|.|. .. .
qteeryvyqyhftvwp....dkgvp...qyatavlglr...rk..i...tkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkai
RLSRPNFVPTLTDYLLC
| || .| | .|..
redrphmvqtseqyvfi
|
|||||||||
| subfamily_ptpA1_pd | Subfamily ptpA1 | 20-204 | 3.1e-19 | 64.0 | In-house | 70-257 (418) | alignment | ||
Range on Protein: 20-204
Range on HMM: 70-257/418.0
GDRAGSnNYINASFMSGYSKKnAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHK--GSENM--------
|. || .|||| .. | | ||.|| || |. ||||.| . | |.||.. ... | ||| . | . | . |. ..
qdkegs.dyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqd
--NRVKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVLQlmdylRKCEIQRSSEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLN
. | . | .. | ..| |.. . || | | | . .. . |. .| ||.. ||.||| .|. .| ||| . ...|.
pereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitn.....rqnqiipssdrnv.....piivhcsagvgrtgtfctavimmkkld
|
|||||||||
| subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 23-241 | 4.4e-18 | 59.9 | In-house | 63-267 (281) | alignment | ||
Range on Protein: 23-241
Range on HMM: 63-267/281.0
AGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNTRS-VTFGPFTVGHKGSENMNRVKVRTLELKY
| .|| | .. | .| || | | ||||.. . ..|.|| |. | . |. |.| |.. . | ..| .. | . . |.| |
knstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy
KEEVHEIRQFEVQTWPTWIQSDgvqSQEqcmdAVlqlMDYLRKCEIqRSSeqsrpgdgPPIlVHCLSGIEESGVFCTVMNCLEQLNNDGAI-DVFQNLRL
. | . | .. . || | . | | . . ||| ||. ||. .|| .|. || . .| .|. . . .. |. | .
egetrlithwlwkewpdwqvpe...sse....vm...lkilrkira.rst........ppv.ihcsagvgrsgtlmaveialqsihshftlpdikqivsh
LRL-SRPNFVPTLTDYLLCYKLLTH
||. | | || .|.| .|.|
lrvtgraasvqtlqqymliwkvlld
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 21-241 | 6.5e-18 | 60.4 | In-house | 13-169 (178) | alignment | ||
Range on Protein: 21-241
Range on HMM: 13-169/178.0
DRAGSNNYINASFMSGYskknaFIATQMPLdstvLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTRsvtfgpftvghkgsenmnrvkvrtlelk
. . |||||.. .. ..... | |...|.... |..|..|.. | ||| ..
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................
ykeevheirqfeVQTWPTWIQSDGVQSQEQCMDAVLQLMDYLRkceiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQlnndgAIDVFQNLRL
.| . | .||.. . ......... .. . .| |.|||| |. ||... .... ..... ..|
............iqylhipipDhgvpdllehflefvefieeal............dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel
LRLSRPnFVPTLTDYLLCYKLLTH
.| || .||. .. .|.. .
vrerRp.ivpnpgqlrqLyefelr
|
|||||||||
| PTPc_DSPc_SM00012 | 125-239 | 1.5e-17 | 59.1 | In-house | 2-103 (105) | alignment | |||
Range on Protein: 125-239
Range on HMM: 2-103/105.0
IRQFEVQTWPTWiqsdGVQSQEqcmDAVLQLMDYLRKCEIQRSSeqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQNLRLLRLSRP
...... .|| || .. |..|.|.....|.. ...| ..|..||| |. .|.|... .|.||.. . .|.|| .. || .||
vkhyhytgwpdh....gvPees...dsilellravkknknkses.......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp
NFVPTLTDYLLCYKLL
. | |...|| .|. |
gmvqteeqylflyral
|
|||||||||
| subfamily_egg_pd | Subfamily egg | 25-255 | 3.8e-17 | 56.9 | In-house | 67-285 (307) | alignment | ||
Range on Protein: 25-255
Range on HMM: 67-285/307.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND-KTCSIYWPVN-TRSVTF--GPFTVGHKGSENMNRVKVRTLELKYKE
....| | ..| | || .| || || ||||.|. .. |.||. . . | ||| . |. . | . . . .. | .||
lddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG
EVHEIRQFEvqTWptwiQSDgvqsqEQCMDAVLQLMDYLRKCeiqRssEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGA--IDVFQNLRLL
.| | | | | | . . | . ||| | . |. |..|.. |. .... .. | .| | . .|
gddeerfle..hw....qgd.....vnnssdvysplrvlrkl...r..nlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvfl
RLSRPNFVPTLTDYLLCYKLLT-HHHTLCRSEEELDY--E
|| |. | . ||. |.|. . . | .||| |
rlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdye
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 116-240 | 4.5e-17 | 56.5 | In-house | 271-382 (392) | alignment | ||
Range on Protein: 116-240
Range on HMM: 271-382/392.0
LKYKEEVHEIRQFEVQTWPTWiQSDgvqsQEQCMDAVLQLMdylRKceIQRSSEQSRpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNL
.. | . |.. || || |.. ..|.|. | .. |... . |||||||| .||||| |.|. |. . ..|.|| .
frslkashtvtqyqfhgwpkh.gsd....qqsgarsllkli...ra..vkgstnskk...efsilvhclsgagrtgvfctameciaqiaegdsvdifqtv
RLLRLSRPNFVPTLTDYLLCYKLLT
..|| | .|| | .| . |..
kilradrmqfvqteeeyafvydvir
|
|||||||||
| subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 28-227 | 4.8e-17 | 56.6 | In-house | 77-265 (301) | alignment | ||
Range on Protein: 28-227
Range on HMM: 77-265/301.0
YINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTR-SVTFGPFTVGHKGSENMNR--VKVRTLELKYKEE
| | ... . . ||||| ||..| ||| .. | . .|.|| | . . |. | ||... .. | |.. | .| . . .. ||||.. .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg
VHEIRQFEVQTWPTWIQSDGVQSQEQCMDavlqLMDYLRKCEiqrsseQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLS
. | . .| . . .| ...| ||. ..| | . ||.||| .|| | | . ....| |.. . |. ||
kfatrtvthyqysewtdrgvPkshaelfd....lmelvkkse......k.......PivvhcsaGiGrsvafigteylareveadptieltealkhlreh
RPNFVP
| | |
rwngvq
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 24-166 | 6.9e-17 | 56.1 | In-house | 54-201 (319) | alignment | ||
Range on Protein: 24-166
Range on HMM: 54-201/319.0
GSNNYINASFMSGYS-KKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVNT---RSVTFGPFTVGHKGSENMNRVKVRTLEL
...|..||.. || .| .||.|..|... ||||.| . . .|. | .| .. |. |.| . ..| . | || | .| . || |
dkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll
KYKEEvHEIRQFEvQTWPTWIQSDgVQSQEQ-CMDAVLQLMDYLRKCEIQR
| .. .| |. | |.... | ..|. . .|. . |. ...
krvdk.eesrelt.hywykwleae.vPaeeaaliamllevrsslksysleq
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 22-134 | 1.6e-15 | 51.5 | In-house | 69-143 (392) | alignment | ||
Range on Protein: 22-134
Range on HMM: 69-143/392.0
RAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkYKEE
..|.|||.. .. ..|.||.|.| ... ||||.|.. ...||.|...|.. ..
dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......................................kgdd
VHEIRQFEVQTWP
.. . || . ||
artvaqfhftewP
|
|||||||||
| subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 26-240 | 9.4e-15 | 49.1 | In-house | 73-284 (305) | alignment | ||
Range on Protein: 26-240
Range on HMM: 73-284/305.0
NNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTfgPFtvGHKGSEnMnRVKVR-TLELKYKEE
.|| | ..| .. . || || ||. | ||| . . .. .|.|| .| .| |. |.. . . | | || . ||. . .||....
heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl..ef..eekgqk.i.svkfessvtlkfrkd
vheiRQFEVQTWPTWIQSDGVQSQEQCMDAVLQLMDYL---RKCEIQRSSEQSRPGDGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ-NLRL
. .|. |. | ... . | | |..|| || | ||| .|| .| . |.|| . |. . |.
....akakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgp.ivvhcsagigrtgsvvmleyildqllagqiiedtdkilqk
LRLSRPNFVPTLTDYLLCYKLLT
.| | | . | ..||. ....
ireqrnnsiqtdaqylfvhqvil
|
|||||||||
| subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 24-241 | 1.9e-14 | 48.4 | In-house | 65-275 (307) | alignment | ||
Range on Protein: 24-241
Range on HMM: 65-275/307.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGP----FTVGHKGSENM----NRVKV
. .|| | .. | . ||..| ||..|. .|| .. . .. ..||| .. . | |||.. . .|| .| |.... . ..|
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv
RTLELKYKEEVHEIRQFEVQTWPtwiqSDGVQSqeQCMDAVlQLMDYLRkceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN-NDGAID
||.... .. |.... . || || . |. |.. | .| |..||| .|. || .. ... |
ttlkvdwaqksrtiqhlqwenwp....drgvpq..inltai.nlleavr.............ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd
VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. . .. || |. . | || ...| .
mkklveelrsqrhyaiqteaqylylhrvlle
|
|||||||||
| subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 21-211 | 2.3e-14 | 47.7 | In-house | 74-258 (310) | alignment | ||
Range on Protein: 21-211
Range on HMM: 74-258/310.0
DRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKgSENMNRVKVRTLELK
|.. ..|| | .. ...|| .| ||. |..||||.. . | .|..| . .. | ||| . |.| | || . .. | .
dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnl.sesseefeicnlavt
Y-------KEEVHEIRQFEVQ--TWPTWIQSdGVqSQEQCMDAVlqlmdylrkceiQRSSEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGA
. |. ..... |. || | . || .|.| || | | | | .||| .|.. .| ... ...|..
fvpdnvpvdeqpanlkelrvslikwpnwpdr.gv.pdekchtvp............qrllaqvrhg...pcvvhcsagkdrlyvvvalklkidkldrglk
IDV
.|.
vda
|
|||||||||
| subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 23-237 | 2.3e-13 | 44.5 | In-house | 77-283 (305) | alignment | ||
Range on Protein: 23-237
Range on HMM: 77-283/305.0
AGSNNYINASFMSG-YSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ---LNDKTCSIYWPVNT---RSVTFGPFTVGHKGSENMNR---VKVR
.|| | .. .. ||..| ||| |. .|| .| . .. |.|| . | |. |||. ... | || |.| ...
pspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqit
TLELKY-KEEVHEIRQFEVQTWPtwiqSDGVQsqeQCMDAVLQLMDYLRKCEIqrsseqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
.|.| | .. .|... || || | . |.|. .| .. ||.||| .|| .| .. ||.. ..
llnltysgdqkmsvrhlqwtewp....drgvp...pckltslellsairgskv.............pivvhcsagigrtgtivaieyilekiaenkpcpp
FQN-LRLLRLSRPNFVPTLTDYLLCYK
. . .. || | . . .|| ..
mpelvkalrdqrafsiqndvqylfihr
|
|||||||||
| subfamily_eak_pd | Subfamily eak | 25-134 | 6.2e-13 | 42.8 | In-house | 77-190 (332) | alignment | ||
Range on Protein: 25-134
Range on HMM: 77-190/332.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ-LNDK--TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKE
. ||||| . . .| | .. .. | ||..| . . .|..| . .. | |.| .|| . || . | | . | ...| |||. .
rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn
EVHEIRQFEVQTWP
| |.. ..| |
ethrvlhykvfGwt
|
|||||||||
| subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 26-241 | 1.2e-12 | 42.5 | In-house | 67-269 (288) | alignment | ||
Range on Protein: 26-241
Range on HMM: 67-269/288.0
NNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVNT-RSVTFGPF-TVGHKGSENMNRVKVRTLeLKYKE
. ||.| .| |. .| .| ||..|. .|... . . |.||..| .| |.|.. ... .| . || | ...... . .| |. ..
dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsl.lrisk
EVHEIRQFEVQTWPTWIQsDGVQSqeqcmdavlQLMDYLRKCEIQRSSEQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
|..| . . | . ||| . . .|| .|. .| .. ||.||. |. .| . .. ||.| | . . . | ||
egeekvivkilhlleWdd.dgvPe.........nylsplrllevlkslqk.......PivvhssaGvGrtgtlililialeslrlddflgirsllaklre
SRPNFVPTLTDYLLCYKLLTH
.| . . | || .... .
erfkaiqtemqylyvhrcvle
|
|||||||||
| subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 25-226 | 5.1e-12 | 40.5 | In-house | 45-242 (290) | alignment | ||
Range on Protein: 25-226
Range on HMM: 45-242/290.0
SNNYINASFMSgYSKKNAFIATQMPL-------DSTVLDFWRLVHDYRISTIIMLNQLNDK-------TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRV
...|| |.... ... ..|.|| |. .||. .|| .... .. ..|| . ..| .|. | | . ...|. .|| | |. . |
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv
KVRTLELKYKEEV-HEIRQFEVQTWptwIQSdGVQSQEQCMdavLQLMDYLRkCeiqrsSeqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLN-NDG
..|.|..|. .|. . . .. | .. || ... . |.|..... . | . |..||| || | .. .. . |
etRelvvkfddeeeftvtHsllkgW...nkl.nvqedtktl...lsliqkvk.a.....s.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsg
AIDVFQNLRLLRLSRPNFV
.. . . | || | . .
svkledvlkalrkqralai
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 99-240 | 8.9e-12 | 40.4 | In-house | 36-140 (145) | alignment | ||
Range on Protein: 99-240
Range on HMM: 36-140/145.0
GhkgsenmnrvkvrtlelKYKEEVHEirQFEVQTWPTWIQSDGVQSQEQCMDAVLQLMDYLRKCeiqrsseqsrpgdGPPILVHCLSGIEESGVFCTVMN
. .| .| .. .| . . . ||.. . ....|.... ..| | |.|||| |. .|... .
l.................tselelle..rlgiqylylpwpDhgvpdllellleflefieealke.............ggpvlVHCsaGvgRtgtlvaayl
CLEqlnnDGaIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
.|. | ..... |.|.| ||..||. . .|....
mll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
|
|||||||||
| subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 26-240 | 2.8e-11 | 37.9 | In-house | 59-267 (285) | alignment | ||
Range on Protein: 26-240
Range on HMM: 59-267/285.0
NNYINASFMSGYSKK-NAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNT-RSVTFGPFTVG--HKGSENMNRVKVRTLELKY
.|| ||.| | ...|.|| || |. |||..... .|. ..|| | . . |..|.| . | || . . | . . .| .
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin
KEEVHEIRQFEVQT-WPTWIqsDGVQSqEQcMDAVLQLMDYLRKCEIQRSseqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRL
|. . . | | | . |. ...| ...| . . || ||| .|. . | . . .. .. |.... .|
tedasseplymnhvqvpwwp..dqlap.ed.arpmielykwvkkvnpkek..........picvhcsagvgrtatfvgidyatirimenpniemldivre
LRLSRPNFVPTLTDYLLCYKLLT
.| | . | . ..|. | .|
mramrfqavqshmqflflyvvlm
|
|||||||||
| subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 25-135 | 7.2e-11 | 36.2 | In-house | 121-232 (244) | alignment | ||
Range on Protein: 25-135
Range on HMM: 121-232/244.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKtcSIYWPVNTRSVTF-GPFTVGHKGSENMNRVKVRTLELKYK-EEV
.| ||||||. . .| || || | .|||... . . ...| .... ||| . || ... .| ||.. .|
gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee..deywpdseplewyeeditvtltdrdefknikasnleiesdmnes
H-EIRQFEVQTWPT
| . |.. ||.
hqaltmfqisnwps
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 25-87 | 1.2e-10 | 35.7 | In-house | 82-153 (350) | alignment | ||
Range on Protein: 25-87
Range on HMM: 82-153/350.0
SNNYINASFMSGY----SKKNAF--IATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVN
.|.||||.... . . | |||| || ||| ||.... . |..|... | . | .||.
tnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
|
|||||||||
| subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 26-242 | 2.4e-10 | 34.5 | In-house | 69-278 (303) | alignment | ||
Range on Protein: 26-242
Range on HMM: 69-278/303.0
NNYINASFMSGYSKKNAfIATQMPLDSTVLDFWRLVHDYRISTIIML---NQLNDKTCSIYWPVNTRSVTFGPF--TVG-HKGSENMNRVKVRTLELKYK
|| ||.. |.|.| | ||.|| | |||... . .. ...| .. .. .| | . | || | | .. ... | .
ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsng
EEVHEIRQFEVQTWPT-WIQSDGvqsQEQCMDAVLQLMDYLRKCeiqrsSeqsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQL-NNDGAIDVFQNLRL
. . ..|| | ||| . . . || .||| | |. | . ||| .| |. . | ... ..|. . |
dyksflhvhhykawphnsipsdg...spkfvkqiwqlqsvlrky.....s......dstptvymslsgcgragtfalfetahlslhseqasldlvkclen
LRLSRPNFVPTLTDYLLCYKLLTHH
.| | | |... . | ||. |
vrngrlhavqnlsqfsvvytllaeh
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 130-237 | 3.4e-10 | 35.4 | In-house | 50-139 (144) | alignment | ||
Range on Protein: 130-237
Range on HMM: 50-139/144.0
VQTWPTWIQSDGVQSQEQCMDAVLQLMDYLrkceiqrsseqsRPgDGPPILVHCLSGIEESGVFCTVMNCLeqlnNDGaIDVFQNLRLLRLSRPNFVPTL
.| . . . || . . ....|.... . .. .| |.|||| |. .|.... .. | ..... |.|.| ||. ||.
iqylhlpwpDhgvpdllellleflefieea............le.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp
TDYLLCYK
. ...
gqlrfLle
|
|||||||||
| subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 24-240 | 6.8e-10 | 32.8 | In-house | 73-282 (302) | alignment | ||
Range on Protein: 24-240
Range on HMM: 73-282/302.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTV---LDFWRLVHDYRISTIIMLNQLNDK--TCSIYWPVNT-RSVTFGPFTVGHKGSENMNRVK-VRTLEL
..|.||| .. . .. | .|.| ... .|||.|.. .| .. .| . .. | | ..| .. ...| . | . |... | ..|.
epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEv
KyKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVLQLmdylrkceiqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
|.. . .|. | |. . ... . . .. .. ... ..| .... |. |.| |.. .|.|... . . . ..
l.PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv............fakkikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivk
LLRLSRPNFVPTLTDYLLCYKLLT
.| ||. | .|. | | |
siRsqRpravdslkQyvslyiall
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 22-84 | 1.5e-09 | 31.6 | In-house | 86-153 (349) | alignment | ||
Range on Protein: 22-84
Range on HMM: 86-153/349.0
RAGSNNYINASFMS--GYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYW
. ..|||| ... .| .. .||||.|| ||| ||.... .. .. ||. .. . | |||
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
|
|||||||||
| subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 22-135 | 2.6e-09 | 31.5 | In-house | 9-123 (130) | alignment | ||
Range on Protein: 22-135
Range on HMM: 9-123/130.0
RAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKtcSIYWPVNTRSV-TFGPFTVGHKGSENMNRVKVRTLELKYK-
| |.||||||. . . .. || || | .|||... . . ...| .... ||| .| .... .| || . .
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..deywpdsePlewyeediivtltdrdefknikasnleiesdl
-EEVHEIRQFEVQTWPT
| . . |.. ||.
neshqaltmfqisnwps
|
|||||||||
| subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 22-78 | 4.5e-09 | 30.2 | In-house | 56-113 (332) | alignment | ||
Range on Protein: 22-78
Range on HMM: 56-113/332.0
RAGSNNYINASFMSGYSKKNAFIATQMPL-DSTVLDFWRLVHDYRISTIIMLNQLNDK
. | ... |||.. |||||.|.| .| |. | | |||.| . . | |... ....|
qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
|
|||||||||
| subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 40-237 | 5.7e-09 | 30.4 | In-house | 4-198 (199) | alignment | ||
Range on Protein: 40-237
Range on HMM: 4-198/199.0
KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDK-TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEE----VHEIRQFEVQ
. .|||| || |. |||..| . |.|.|. | . ..|||. . .| ..| | . .| | . || ...
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft
TWptwiqsdgvqsQEQCMDAVLQLMDY-LRKCEIQRSSEQSRpgDgPPILVHCLSGIEESGVFCTVMNCLEQLN--NDGAIDVFQNLRLLRLSRPNFVPT
.| .|. | .. . . |. . || . | |..||| | .||| .. . . . .|.|. . || .| . .
sw...........kekttpnvalfvgfvvasrevskkyeqek..d.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss
LTDYLLCYK
| | . |.
lqhynfiyq
|
|||||||||
| subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 41-237 | 6.3e-09 | 30.3 | In-house | 4-197 (198) | alignment | ||
Range on Protein: 41-237
Range on HMM: 4-197/198.0
NAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDK-TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEE----VHEIRQFEVQT
.|||| || |. |||..| . |.|.|. | . ..|||. . .| ..| | . .| | . || ... .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts
WptwiqsdgvqsQEQCMDAVLQLMDY-LRKCEIQRSSEQSRpgDgPPILVHCLSGIEESGVFCTVMNCLEQLN--NDGAIDVFQNLRLLRLSRPNFVPTL
| .|. | .. . . |. . || . | |..||| | .||| .. . . . .|.|. . || .| . .|
w...........kekttpnvalfvgfvvasrevskkyeqek..d.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
TDYLLCYK
| . |.
qhynfiyq
|
|||||||||
| subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 25-73 | 9e-09 | 29.3 | In-house | 69-117 (347) | alignment | ||
Range on Protein: 25-73
Range on HMM: 69-117/347.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLN
...||||| . .. .| || || .|| |||..|. ... .. .
vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
|
|||||||||
| subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 180-238 | 3.1e-07 | 24.7 | In-house | 2-60 (69) | alignment | ||
Range on Protein: 180-238
Range on HMM: 2-60/69.0
LVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKL
.||| || .| | ..| . .. . .|.| |.. .| || | .|.. .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
|
|||||||||
| subfamily_Sponge-PTP7_pd | Subfamily Sponge-PTP7 | 181-239 | 6.4e-07 | 23.6 | In-house | 2-60 (69) | alignment | ||
Range on Protein: 181-239
Range on HMM: 2-60/69.0
VHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
||| || .| | ..| . .. . .|.| |.. .| || | .|.. . |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
|
|||||||||
| subfamily_hpo-7_pd | Subfamily hpo-7 | 40-227 | 8.1e-07 | 23.2 | In-house | 37-211 (263) | alignment | ||
Range on Protein: 40-227
Range on HMM: 37-211/263.0
KNAFIAtqmpLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTR-SVTFGPFTVGHKGS--ENMNRVKVRTLELKYKEEVHEIRQFevqTW
|| .. | |. |.. . . ....|| |.. || |.|.. . .| . . . . .. . |. | ..|..... .
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhy...sy
PTWIQSDGVQSQEQCMDaVLQLMDYLRKCEIQRSSEQSRPGDgppilvhclSGIEESgVFCTVMNCLEQLnNDGAIDVFQNLRLLRLSRPNFVP
||. ... ... . .|.. ... .. |. | ..|. |. ... |.. . . .| . |. || ||. ..
kgWiekndpelareiln.ilkvarnskslvvhcstGiGrsaa.........fsvaEl.vyqkmirsldtt.stveldylsLleelrssrkraih
|
|||||||||
| subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 25-77 | 7.1e-06 | 19.9 | In-house | 66-118 (312) | alignment | ||
Range on Protein: 25-77
Range on HMM: 66-118/312.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND
| || | |. .| . |..|| ||..|. ||.|. ..||.| . .
enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfve
|
|||||||||
| subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 45-144 | 7.5e-06 | 20.2 | In-house | 39-134 (255) | alignment | ||
Range on Protein: 45-144
Range on HMM: 39-134/255.0
AtqmpldsTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTR-SVTFGPFTVGHKG--SENMNRVKVRTLELKYKEEVHEIRQFEVQTWPtwiQ
|| |.. . . ....|| ... . || |.|.. . .| .. . | . |..| | . |... .. . |. .
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWi...e
SDGVQS
. .
knaPel
|
|||||||||