Gene SpurPTP-sf3-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP098_AA protein Get Run
SpurP098_AA_135-418 phosphatase_domain Get Run
SpurP098_AA_430-711 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 129-454 4.1e-203 668.5 In-house 1-325 (325) alignment 
Range on Protein: 129-454
Range on HMM: 1-325/325.0
LPGSIAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPN
||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.||.|.|||||||.||||.|||.||.|.||||.|..|.|||||.
lpgsiavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPl

TASINDFWRLI--WQenvCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYP
||.|||.|||.  |.   ||||.|.|.|..|||||.|||||||||||||||.|||||||||.||.||||||||||..||||||.||..|||.||||...|
tatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrp

TTLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPV
.||||..|.||.|.||.|||||.|||.||||||||||||.|||||..||.||||||||||||..|.|||||.||.|.||||||..|||||||||||||||
atlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpv

SSFEAKLSSLQERNPLTQKLNIEQEFEI
|||||||||||||||||||||||.||||
ssfeaklsslqernpltqklniekefei
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 457-711 1.2e-142 469.8 In-house 30-289 (325) alignment 
Range on Protein: 457-711
Range on HMM: 30-289/325.0
QLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD
.|.|.....|.|.|..|.|..||||.||....|.|..|.||....|.||||||.|....|||||||.|.||..|..|.||.|.|||..|.|.||||||..
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk

KSCAQYWPNK--DSVQFGPLKVSIISAETIrSDYVMRKFEIKGPKKG-TLTVKQFQLMGWD--GNQKRPASLAPILHLVDAVSECVRT-SQASGPIVLHC
..||.|||..  .|..||.|.|.....|.| ||||.|....|..||| |..||||||..||  |.|||||.|..||.||.||||.|.. ..||.||..||
drcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

INGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
..|.||.|||...|||..|.|..|.||||..||.||..||||.|.||||...||...|.. 
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_PTPRD_pd Subfamily PTPRD 133-494 4e-123 407.0 In-house 5-357 (564) alignment 
Range on Protein: 133-494
Range on HMM: 5-357/564.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| | .| |||.| ||...  | .|.  . . .   ...| ||.||||||..||||.|||||||.... |. ||| ||..|   . .|..||.|.|   .|
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
.||||..|..|....||.|.. | ||..|  |||.. | ..|.|...|.|   ||..| . | . .|. .  |.| |.|||. |||| |||...|.|.. 
edFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

TQTVKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAK
 ..|....|      ... |..|||||||||||||| . .|| .. ||  |||.......||.|. |||| .||| ||.|..||  .|||.|........
irkvralne......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh

LSSLQERNPLTQKLNIEQEFEILNqLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCL
|. |.| .. |.  ..|.||. |.  . .. .. |..|  | | .||||.|.|..|..|  |
lqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescrvvl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 133-454 5.2e-96 316.4 In-house 2-317 (318) alignment 
Range on Protein: 133-454
Range on HMM: 2-317/318.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLL-PSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTAS
| | .| .||.. ... .  . .|.  | .|.. .... ...| ||||||. ||.|.||.|| |..|.... ||| |||||   . ||..|||||| .  
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLIS
|.||||..|. | . .||.|.. | ||...  |||..  .|...| . |.|.   |.||.| | . |..    |.| |.|.|| |||| |||. ...|..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

YTQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEA
  ..|....     ...| .|..|||||||||||.|| .  .| .. .|. ||.|......|. |. |||| |||..|...|.|| .||.|.|  | . .
lvrqvskaq.....qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrs

KLSSLQERNPLTQKLNIEQEFEI
..  |.|..| . . ... ||. 
rirelreqdpesgttemdaefqr
subfamily_PTPRB_pd Subfamily PTPRB 132-420 3.9e-91 300.1 In-house 6-288 (293) alignment 
Range on Protein: 132-420
Range on HMM: 6-288/293.0
SIAVVNLVEHVEKKKAQDQDGFAHEFGLLPS-DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTA
 | . .. |||.|.||... .|..|.  | . .   |...| ...|.||||..||...||||| |..|||...||| |||||.. . .. |||.| |   
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

SINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQvsGGETRSVHQFHYQSWPDMGVPQYPTTLI
...||||..|....  .||.|...|.|| .|  |||..  .. ..| |.|.| . || .|.| | | ...  . |.|.|.|.|..|||| |||. ..||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

SYTQTVKHVHERitanTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSG
....||....|.    |. ..|..||||||||||||||.|  .| .. ||  |||||.....|..| ..||| .||| ||.....  ...
dfvrtvreaiek....taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
0050432 (Phosphotyrosine protein) phosphatases II 134-422 5.4e-91 300.4 In-house 27-304 (308) alignment 
Range on Protein: 134-422
Range on HMM: 27-304/308.0
AVVNLVEHVEKkkAQDQDGFAHEFGLLPSDDGIAK-TVAMKPENKAKNRFKNIVAFDHSRVVLetlkdDPHSDYYNANYIRDD--KGKKTFIAAQAPNTA
 | .|....||  | |  ..  ||  |.|   . . .||..|||| |||.|.|...|||||.|     |..|||.||.|..    | ...|||.|.|   
svldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn

SINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMG-KSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTL
...||||..|..||  .||.|.. | |.  |  ||| |.| .|...|.. |.|. .|...|...|.| .. ...||.| |..||| .|||.|||..|. |
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

ISYTQTVKHVHeritantkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNT
... . |....        .. |..|||||||||||||| |...| |. .| .||.|. ..|.|. ||.|||| .||.... ||.| ...  |
ldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 133-417 1.5e-90 298.9 In-house 5-286 (288) alignment 
Range on Protein: 133-417
Range on HMM: 5-286/288.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAK-TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTAS
| | .|...|.|..| .. |.. ||  |.|     . ..|..|||. |||...|...|||||.| .|.....|||.||.||.  . |..|||.|.|   .
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV----SGGETRSVHQFHYQSWPDMGVPQYPT
..||||..|..||  .||.|.. | |.  |  |||   |.|.|.| | |.|. .|...| ..|.| |. .     .||.| |..||| .|||.|||..|.
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

TLISYTQTVKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
 |... . |.....      .|. |..|||||||||||||| |...| |. .| .||........|. ||.|||| .||.... ||.|..
llldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 133-452 1.8e-90 298.2 In-house 5-318 (319) alignment 
Range on Protein: 133-452
Range on HMM: 5-318/319.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| | .| |.... ... . ....|| ||   .    . | |.||| |||..||.|.|..|||| .|.. . ||| ||..|   . .. |||.|||    |
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLIS
.||||..|.|..  |||.|.. | .| ..  |||.|  . ...| . |.|   || .| . | | ... |.  |||.| .|.|..||| .||.. |.|. 
edfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslld

YTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEA
  . ... .|.     . | |. |||||||||||||| |  || .| ||. .|.| .....|  |. |||. .||..|. ||.||  .|.|.. |  .. 
llkrirksrek.....tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd

KLSSLQERNPLTQKLNIEQEF
.| .|.|... | .  .|.||
rlkqlaekvadtgetgleref
0040438 (Phosphotyrosine protein) phosphatases II 136-453 4.3e-89 294.2 In-house 3-312 (317) alignment 
Range on Protein: 136-453
Range on HMM: 3-312/317.0
VNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDF
..|...... .. |  ..  ||  |.| .    .||..|||| |||...|. .|||||.|  |. |..|||.||.|.   . |..|||.|.|   ...||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQT
||..|...|...||.|.  | |.  |  |||   |...|.|.. |.|. .|| .. ..|.| |.   ..|.| |..||| .|||.|||..|..|..  . 
wrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

VKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSS
|... |      ....|.||||||||||||||| .|.|| |. .| .||..  ....|. ||..||| .||. ...|| | .. ..|..|.|..  ||  
vreale......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk

LQERNPLTQKLNIEQEFE
|..  .|..  ..|.|..
lliplalddvklkekelk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 137-424 2e-88 291.5 In-house 13-297 (298) alignment 
Range on Protein: 137-424
Range on HMM: 13-297/298.0
NLVEHVEKKKAQDQDGFAHEFGLLPSDDG----IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
 | . ...||...  |.|.||  | |         |.|| ||||| |||. .|.|.|.||||||. ..| .||| || ..   ||...|||.||| |...
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
.||||....|.. ..||.||. | .| ... |||.|  ...|.| |.|.|.  |||.| . | | |.. .  ..|.|.|.|. |||| |||.. |... .
edFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

TQTVKHvheriTANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDV
 . |.      . .  | .|..|.|||||||.|||| .. .| .| .|. ||.|  .. .||.||..||| .||. |..|  ||  |.|...
lrkvra.....sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPRA_pd Subfamily PTPRA 133-452 3e-88 290.9 In-house 14-330 (330) alignment 
Range on Protein: 133-452
Range on HMM: 14-330/330.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPS-DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTAS
. | .| | .....|.|   |  ||  ||. .   .  .| | ||| |||. ||. .|.|||.| ...  ..||| || .|   | |..||||| | . .
lpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeet

INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGE----TRSVHQFHYQSWPDMGVPQYPT
..||||.||. . ...||.|.. |  ...|. |||.| | . |.| | |...  ..  |   | . |.|.. .     .| |.|||..||||.|||  | 
vedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi

TLISYTQTVKHVHERitantKGStPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVS
 .... . ||.....     ... |. |||||||||||||| |  .|..|  | .||.|.|....|. ||.||||  || .|. .| | |. |.|.. ||
Gmlkllkkvkklnqq.....sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs

SFEAKLSSLQERNPLTQKLNIEQEF
|.| .| .|... . |.|  .|.||
slekhlqklynkitgtdkigleeef
0036941 (Phosphotyrosine protein) phosphatases II 167-427 3.9e-88 290.9 In-house 30-287 (297) alignment 
Range on Protein: 167-427
Range on HMM: 30-287/297.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLetlkDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
 ..||..|||. |||.|.|...||.||.|    ||..|||.||.|.   . |..|||.|.|   ...||||..|..|| ..||.|.  | |.  |  |||
slsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp

KEMGKSKTFGGIEVKLRTIEE--FSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantKGSTPMLVHCSAGVGRT
 |.|.|.|.|.. |.|...|.  ..| . |.| |. . .||.| |..||| .|||.|||..|..|... . |..|.. .     ...|.||||||||||.
leegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll....psggpvlVHCsaGvgRs

GTFISLYCMLAQVI---EESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVS
|||| ...|| |.    .| .|||. ...|.|. ||..||| .||. .. || | .....|..|..
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
0046845 (Phosphotyrosine protein) phosphatases II 166-423 4.1e-88 290.7 In-house 15-280 (284) alignment 
Range on Protein: 166-423
Range on HMM: 15-280/284.0
I---AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDD-PHSDYYNANYIRDD-----KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEG
      .||..|||. |||.|.|...|||||.| .|..| ..|||.||.|..       . ||.|||.|.|   ...||||..|..||  .||.|.. | 
klllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelven

GKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS-GGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitanTKGSTPMLV
|.  |  ||| | |...|.|.. |.|. .|...|...|.| .. .. .||.| |..||| ||||.|||..|. |... ..|....|.    ..|. |..|
grekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen....lpgggpivV

HCSAGVGRTGTFISLYCMLAQVIEES---RVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTD
||||||||||||| |...| |...|.   .||... ....|. ||.|||| .||.... ||.|......| 
HCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 136-416 9.6e-88 289.0 In-house 6-278 (288) alignment 
Range on Protein: 136-416
Range on HMM: 6-278/288.0
VNLVEHVEKKKAQDQDGFAHEFGLL-PSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASIND
.. |..| ||.|....|| .|.  | . .   ..|.. ...|. |||..||...|. || |. |.. . .|| ||.|| ..|.||..||.|.|.....||
ispvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKqvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQ
||.|......  .||.|...|||| .|  |||.. .| | .| ..|.|.  .|  |.|.| | ..    .. . ..|..|..|||.|||.  . |. . .
fWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr

TVKHVHERItantkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
.||  ..        . |..||||||||||||||.| ... .| ||  .|..|...|.|| |...|||  ||. |. .|.. 
qvkvanqad......tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0047943 (Phosphotyrosine protein) phosphatases II 146-416 9.6e-86 282.9 In-house 7-271 (273) alignment 
Range on Protein: 146-416
Range on HMM: 7-271/273.0
KAQDQDGFAHEFGLLPSDDGIA-KTVAMKPENKAKNRFKNIVAFDHSRVVLetlkDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENV
|. . .... || ||.|   .  ..||..|||| |||.|.|...|||||.|    .|..|||.||.|..  . |..|||.|.|   ...||||..|..||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

CSVVMVTNILEGGKDRCTVYWPKEMGK-SKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERI
  .||.|.. | |.  |  ||| |.|. |.|.| . |.|. .|...|...|.| .. .. ||.| |..||| .|||.|||.... |... . |....| .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

TANtkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
  |    .|..|||||||||||||| |...| |...| .||..  ....|. ||.|||| .||.... ||.| 
psn....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 133-437 4.1e-85 280.6 In-house 4-303 (305) alignment 
Range on Protein: 133-437
Range on HMM: 4-303/305.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDdGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
||. .| ............|. ... .|... . .  |  | .||||||.|.|. .|..|. | . .....||| ||.|.   |.||..|.||.|    .
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQ-VSGGETRSVHQFHYQSWPDMGVPQYPTTLIS
.||||||..| | ..||.|.. |||||.|  |||......| || ..|.|.  ...||.. | | . .  .  |.|.| |..  .||| ||||..|.|.|
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

YTQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEA
  . |.. .     .    .|.||||||||||||.||..  .| .. .|  ||.|. ....|. |..|||| |||  .| || |   .|.|.. .| ..|
likrvqkdq.....kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlra

KLSSLQ
..  |.
rvnklk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 150-461 5.2e-85 280.5 In-house 17-320 (515) alignment 
Range on Protein: 150-461
Range on HMM: 17-320/515.0
QDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVM
   |. ||  ||  .   .||| .  |  |||.|||. .| .|| || ..|.|||||.|| ||.  .  |..||.|.|| ||..|||||..||||  ..|
ttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiam

VTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVkqVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITantkg
||.  || | .|. |||.  |.|  || |.|.| ..|  .. . | | |  . | ..| | |||.. ||| |||.  ..|. . . ||  |...|     
vtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.....

sTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQERNPLTQKLNIE
  |...|||||||||| .||.  ..|.. .   ||.| |....|..|| .||| .|| .|. |. |  .  || .||  |  .|  |.       . .. 
.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmt

QEFEILNQLTPP
.||. |. |.| 
kefqtlkslcpd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 133-452 4.2e-84 277.1 In-house 6-314 (315) alignment 
Range on Protein: 133-452
Range on HMM: 6-314/315.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| . .|. .| .|||  ..|| ...  .|  .     || | ||| |||. ||.|.|.||| |  |. |||||| |||.|   . |. .||||.||.||.
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv

NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgkSKTFGGIEVKLRTIEEFSDHVHRVLdvKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
.|||||...|..  .||.||. || | ..  ||| .     ..| | | ..  | ...   | |    |.| . | | |.|| ||||||||.| ..|. .
kdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

TQTVKHVHERITantkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAK
 .|||  |.         ....||||||||||||||.| ..| |.  |  .|.. ||...|. | .|||.|.|| .|. ||.|... |.| .    .  .
irtvkqhhtnsv......gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqr

LSSLQERNPLTQKLNIEQEF
  ||   .| |    ....|
ydsllapspdtgstllqeqf
0043336 (Phosphotyrosine protein) phosphatases II 134-415 2.8e-83 274.9 In-house 3-275 (278) alignment 
Range on Protein: 134-415
Range on HMM: 3-275/278.0
AVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASIN
 | .|......... .. ..  ||  |.| . . ...|..|||| |||.|.|...|||||.|. |. |..|||.||.|.   . ...|||.|.|.. ...
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPkemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYT
||||..|...| ..||.|.  | |.  |  |||   |.|.|.|.. |.|. .|...| ..|.| |.    ||.| |...|| .|||.|||  ...|... 
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

QTVKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
..|... |      . ..|.||||||||||||||| || .| |.  | .||..  ....|. ||..||| .||. .. || |
kavreale......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
DSPc_SM00195 167-417 4.5e-83 273.9 In-house 17-262 (263) alignment 
Range on Protein: 167-417
Range on HMM: 17-262/263.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
 .| | |..||.|||.|||. .||.|| |.. .....|||.|||||. .. ||..||.|.|    ..||||..|.|.|  .||.|.  | || .|. |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

KEMGKSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantkgSTPMLVHCSAGVGRTG
.|.|...||| |.|||.  |. . . . |.| ...    |||.|.|..|..||| |||. .. .... ..||. ....      |.|..|||||||||||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtg

TFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
||... ..| .. ||..||||  ....|| ||.|||| .||. |..|..|..
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 167-417 4.5e-83 273.9 In-house 17-262 (263) alignment 
Range on Protein: 167-417
Range on HMM: 17-262/263.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
 .| | |..||.|||.|||. .||.|| |.. .....|||.|||||. .. ||..||.|.|    ..||||..|.|.|  .||.|.  | || .|. |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

KEMGKSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantkgSTPMLVHCSAGVGRTG
.|.|...||| |.|||.  |. . . . |.| ...    |||.|.|..|..||| |||. .. .... ..||. ....      |.|..|||||||||||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtg

TFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
||... ..| .. ||..||||  ....|| ||.|||| .||. |..|..|..
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 142-422 2.4e-82 272.0 In-house 23-294 (297) alignment 
Range on Protein: 142-422
Range on HMM: 23-294/297.0
VEKKKAQDQDGFAHEFGLLPSDDGIaKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKD-DPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLI
. ..|| .  ..  ||  |.|     ...|..|||| |||.|.|...|||||.| .... |..|||.||.|.   .  ...|||.|.|.. ...||||..
lllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WQENVCSVVMVTNILEGGKdRCTVYWPKEMGkskTFGGIEVKLRTIEEFSDHVHRVLDVKQvsGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHV
|...| ..||.|.  | |.  |  ||| |.|   |.|.. |.|...|. .. ..|.| |.   .||.| |..|.| .|||.|||.....|..  . |...
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrea

HERItantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNT
...     ....|.||||||||||||||| .| || |. .| .||..  ....|. ||..||| .||. .. ||.| .. ..|
lael....pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Ptp69D_pd Subfamily Ptp69D 131-436 2.6e-82 271.4 In-house 2-305 (307) alignment 
Range on Protein: 131-436
Range on HMM: 2-305/307.0
GSIAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDD-GIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNT
|.||...| | ....| . . |.|.|.  |..       .|. | ||. |||...|.|||. ||.|.... . .||| ||..|.  | ||.|||||.|  
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS--G---GETRSVHQFHYQSWPDMGVPQ
| |.||||.|.. .|  .||..|. |  ...|  |||.|  . . .| | |||   |. ||...| ||| ..   .    ..| | |.||..|.|. ||.
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

YPTTLISYTQTVKHVHERItantkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDV
 ...|. . . |.....         .|..|||||||||.|.|..|  .| |. .| .|||| .....|..|. .||  .||. .. ||..  . |.||.
vargllklieqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtde

PVSSFEAKLSSL
 | ..| .. .|
dvddledaierl
0045450 (Phosphotyrosine protein) phosphatases II 128-417 3.5e-82 271.9 In-house 4-304 (307) alignment 
Range on Protein: 128-417
Range on HMM: 4-304/307.0
SLPGSIAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGI---AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDD-PHSDYYNANYI--------RDD
.|   | ...|. .| .... .  |.. ||  |.|   .     ..|..|||| |||.|.|...||.||.| .|... ..|||.||.|.           
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV-SGGETRSVHQFHY
. |..|||.|.|   ...||||..|...|  .||.|.  | |.  |  ||| | | ..|.| . |.|. .|. .. ..|.| |.     ||.| |..|||
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

QSWPDMGVPQYPTTLISYTQTVKHVHERItantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESR---VDIFGFIQKMRKDRPNMVQTADQYILIHT
 .|||.|||... .|..  . |....|.     ....|.||||||||||||||| .| || |. .|     ||..  ....|. ||..||. .||. .. 
tgwpdhgvppsfeelldfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

ALVEAY
|| | .
allell
subfamily_PTPRK_pd Subfamily PTPRK 133-453 1e-81 269.2 In-house 4-313 (314) alignment 
Range on Protein: 133-453
Range on HMM: 4-313/314.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDdgiaKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| | .|.... . |. .  || .|.  |.        .| | ||..|||...|.|.|.|||.| |...||.||| ||..|   |  . ||..| |    .
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS--GGETRSVHQFHYQSWPDMGVPQYPTTLI
.|||||...|| .|.||.|.. | |. .|. |||..   ....| |.|.|   |  .. |.|.. |....    |.| |.||.. .||| .||.. |.|.
kdfWrlvydencasivmltelvevgrvkClkyWPed...tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

SYTQTVKHVHERitantkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFE
.. . ||. .|       .  ...|||||| ||||||| .  .|  . .|. ||.|  ....|. ..|||.| .||..|. ...|| . |.| .||| |.
klvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefk

AKLSSLQERNPLTQKLNIEQEFE
|   . .. .| |.  ....||.
alylesirldpqtnssqlkeefq
subfamily_PTPRG_pd Subfamily PTPRG 134-430 2.1e-81 268.9 In-house 2-300 (563) alignment 
Range on Protein: 134-430
Range on HMM: 2-300/563.0
AVVNLVEHVEKKKAQDQDGFAHEFG---LLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHS-DYYNANYIRDDKGKKTFIAAQAPNT
 | ....|| . .|... ||..||        .. .  . . ||||| |||  ||||.|.||| |. | .  .. || |||||   . .| |||.| | .
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

ASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV--SG----GETRSVHQFHYQSWPDMGVP
  ..||||.||..||  .||.||. | |.  | |||||   .|.|.| ..|.| . | ..    | | .|..         . . | |.|| .|||.|||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

QYPTTLISYTQTVkhvherITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTD
....  ... .         .|| .   |..||||||||||||.| |  .| |. .|. |..|||....|  |...||| .||| .| ||.|| .|..|.
ehslpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete

VPVSSFE
.  .  |
llaeqve
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 138-417 4.5e-81 267.0 In-house 2-276 (281) alignment 
Range on Protein: 138-417
Range on HMM: 2-276/281.0
LVEHVEKKKAQDQDGFAHEFGLLPS-DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFW
| .|.......|. ||..|.  | . . . . | . ..||. |||..||||.|..||...  ... ..|| |||..   ||.| .||.|.|  ||...||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RLIWQENVCSVVMVTNILEGGKDRCTVYWPkEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVkQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTV
...|...|. .||||. .|.|| .|  ||| .  .. ..| . ||  . || . ...|.. . . ..||||.|.|..|..||| |||. .. |... . |
qmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkev

KHVHERITAntkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEE-SRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
....|. |      .|...|||||||||||.|.|  .. .| .| ...|.   ....||.|  ||||  ||  .. |...| 
lkltekktk.....aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 146-453 5e-81 267.0 In-house 14-313 (315) alignment 
Range on Protein: 146-453
Range on HMM: 14-313/315.0
KAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVC
| .    |..||  ||  |   ..|| ...|  |||.|||. .|..||.|| . |.|.|||.|| ||.  .  |..||.|.|. ||..||||...||.| 
knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvt

SVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLdVKQvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHErita
..||||.  || | .|  |||.. ..|  || |.|.|  .|  .| |.| | | .  . |.| | ||... ||| ||..  ..|. . . ||  ..    
tivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtr.kseesrtvtqfqftewPdkGvdkqtssllklikevkadng....

ntKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQERNPLTQK
  |   ..|||||||||||| .||.  ..||. ... ||.| |....|..|| .||| ..| .|. |. |  .  || ..|  |  .|  |.     . .
..kkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgr

LNIEQEFE
 .. .|||
skmtkefe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 169-419 3.8e-80 263.7 In-house 2-244 (250) alignment 
Range on Protein: 169-419
Range on HMM: 2-244/250.0
TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDrCTVYWPKE
.|| ||.|| |||. .|.|.|.||||||. | | .||| || ..   ...|.|||.|.| .|.|.||||....|.. ..||.||. | .|  .. ||| |
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

mgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantkGSTPMLVHCSAGVGRTGTFI
  |....|.. |.|   |||.| ..|.| . . .  . | | |.|. .||| |||.. |. . . . |.  ....     |..|..|.|||||||.|.||
..kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.....gnaPvivqCsaGvgrsGafi

SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
 ....| .. .|  ||.| .|...|||||..|.. .||. ..... .|  |
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN12_pd Subfamily PTPN12 166-416 4.1e-79 260.5 In-house 30-276 (290) alignment 
Range on Protein: 166-416
Range on HMM: 30-276/290.0
IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYW
. .... |.||..|||.|.|. .|.|||.|.. .....||| |||.|.  .||...||||.| .. ..||||.||. ||  |||. ...| || .|  ||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PKEMGKSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVsgGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHEritantKGSTPMLVHCSAGVGRT
|.|.... .|| .||.| . . .. |.. | | |..   .|.|.|.||||..||| |||. ...|.. ...|....|      . ..|..||||||||||
peegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe......sedaPlvvhCsaGvGrt

GTFISLYC---MLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
|| |..     .| . . ....|.|  ....||.|. .||| .|| |.. |..| 
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
0040439 (Phosphotyrosine protein) phosphatases II 169-417 5.4e-78 257.3 In-house 4-246 (249) alignment 
Range on Protein: 169-417
Range on HMM: 4-246/249.0
TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKe
.||..|||| |||...|...|||||.|. |.. ..|||.||.||   . |..|||.|.| . ...||||..|.... ..||.|.  | |.  |  |||  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

mGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantKGSTPMLVHCSAGVGRTGTFI
 |.|...|.. |.|. .|...| ..|.| .. .  ||.| |....| .|||.|||... .|... . |....|..    . ..|.|||||||||||||||
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtGtfi

SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
 .| || |. .| .||..  ....|. ||..||. .||. .. || | .
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 176-414 1.8e-77 255.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 176-414
Range on HMM: 1-234/235.0
NKAKNRFKNIVAFDHSRVVLetlKDDPH-SDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
|| |||.|.|...|..|| |   |.... |||.||||..  | ||.|||.|.|   .|.||||..|||.| ..||.|.  | |.  |  |||.|...|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGGIEVKLR-TIE-EFSDHVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSAGVGRTGTFISLY
.| |.|.|.  .. . .. . |.|..|.  .  |.|.|.|.||..||| |||. |. |... . |.. .      .. |.|..|||||||||||||..| 
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvald

CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
..| |. .|. ||.. .....|| ||.|||...||| .. |..
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 176-414 1.8e-77 255.3 In-house 1-234 (235) alignment 
Range on Protein: 176-414
Range on HMM: 1-234/235.0
NKAKNRFKNIVAFDHSRVVLetlKDDPH-SDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
|| |||.|.|...|..|| |   |.... |||.||||..  | ||.|||.|.|   .|.||||..|||.| ..||.|.  | |.  |  |||.|...|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGGIEVKLR-TIE-EFSDHVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSAGVGRTGTFISLY
.| |.|.|.  .. . .. . |.|..|.  .  |.|.|.|.||..||| |||. |. |... . |.. .      .. |.|..|||||||||||||..| 
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvald

CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
..| |. .|. ||.. .....|| ||.|||...||| .. |..
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN6_pd Subfamily PTPN6 138-420 4.6e-77 254.0 In-house 12-299 (306) alignment 
Range on Protein: 138-420
Range on HMM: 12-299/306.0
LVEHVEKK-KAQDQDGFAHEFGLLP---SDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLEtLKDDPHSDYYNANYIRD--DKGKKTFIAAQAPNTAS
 |...||. .  .. ||  ||  |    . . . .. . ||||| |||.|||. |||.||.|.  .. | ||| |||||..   . .|..||.|   .. 
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKtFGGIEVKLRTIEEFSDHVHRVLDVK-QVSGGETRSVHQFHYQSWPDMGVPQYPTTLI
..||||..||||   .||.|. .| ||..|. |||.|  |.. .| |.|.  . .. .| . | | |. . ...|.|.|.|.|..|||| |||. | ...
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

SYTQTVKHVHERITANtkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIE---ESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALvEAYMSG
.. ..|.. .|.....   . |..||||||.||||||| . ..| .. .   .  .||  .....|. |  .|||..|| ....|. ..|.  
dfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyiet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 146-430 1.7e-76 252.2 In-house 21-297 (297) alignment 
Range on Protein: 146-430
Range on HMM: 21-297/297.0
KAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGkkTFIAAQAPNTASINDFWRLIWQENVC
| .. | | .||  ||.    ..||| |  |  |.|.|||. .| ||| |. . ||| ||| || ...  |    .|. | |. |...|||.....|.| 
knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvs

SVVMVTNILEGGKdRCTVYWPKEMgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQ--YPTTLISYTQTVKHVHERi
 .||...  |. | .|. ||...   ..||| . |.| ...| .  ..| |.|.. .   .| |.|... .|||  |..    ..|. . . |.....  
tivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsq.

taNTKGstPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFE
  |..|  |.||||.||||||| ....  ..|.. .|  |||||...|.|..||..||| .|| ... |..|| .| .|....| ||
..naeg..PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 150-438 9.2e-76 250.2 In-house 33-312 (319) alignment 
Range on Protein: 150-438
Range on HMM: 33-312/319.0
QDGFAHEFGLLPS--DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSV
.  .  ||  ..    ..  .| |  ..|| |||. ||.|||...| || |     ||| || ..   . |. .|||| |   ...||||.||. |....
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMVTnileggKDRCTVYWPKEMgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQ-VSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitan
|..|      ||.|. |||...   .. .  .||. ..|| ...| | ... .     . |...|||.. |||.|||.||. |.   . |.|....    
vllt......kdkcsqywplki..vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk....

TKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQE
 .. ....|||||||||||..| | ..| .. ||..||.. |.. .|..|...||   || .|..||.| .. |..|| .  | | |  | .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
0042113 (Phosphotyrosine protein) phosphatases II 169-415 1.5e-75 249.1 In-house 2-241 (245) alignment 
Range on Protein: 169-415
Range on HMM: 2-241/245.0
TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKe
.||..|||| |||...|...||.||.|   . |..|||.||.|.  .. ...|||.|.| . ...||||..|.... ..||.|.  | |.  |  |||  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

mGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFI
 | |.|.|.. |.|...| ..| ..|.| |. .  .|.| |...|| .|||.||| .. .|..  . |... ..     ....|.|||||||||||||||
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfi

SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
 .| || |. .| .|...  ....|. ||..||| .||. .. || |
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 171-416 4.3e-75 246.9 In-house 2-239 (239) alignment 
Range on Protein: 171-416
Range on HMM: 2-239/239.0
AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEM
| |  ||||||. |||..|||||||| | .|||||| ||.|.||  |  |..||.|   ..|  ||||..|||  | .||.| ..|| | .|  |||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

GKsktFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQtvkhvheRITA-NTKGSTPMLVHCSAGVGRTGTFI
 |   .  . | ||  | |.|.. | . . ||   | | |.|.|.  ||| ||||| |...   .       .||  .  |. | ..||||||||||.|.
sk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.......kitkdslpgarpwvihcsagvgrtgafl

SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
 . .|| |  ..  |||| ... .|.||| ||||..||..|| |..||
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
0050432 (Phosphotyrosine protein) phosphatases II 436-715 5.7e-75 247.8 In-house 32-304 (308) alignment 
Range on Protein: 436-715
Range on HMM: 32-304/308.0
LQERNPLTQKLNIEQEFEILNQLTPpvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtkgeAGSTDYINASFLNTF--IKKDVFLATQMPLPHTTGD
|.  ...... ..|.||| |....|   .  ...| ||.|.||||....|| ...| .|      ...||||||. ...  ...  |.||| |||.|..|
lkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved

IWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNK---DSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILH
 |||| .....|||||..|.  . . ||||||..   .|...|...| ..| |. ..||..|..|..   .. ..||..|. ..|  ... | |....|.
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeilld

LVDAVSECVrtsqASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
....| ..      .|||| || .|.||.|.|.|.. . | . ..  ||.|. ||.||  || |.....||  .|. ..||.|..  
flelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 165-438 1.1e-74 246.5 In-house 14-276 (284) alignment 
Range on Protein: 165-438
Range on HMM: 14-276/284.0
GIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTnileggKDRCTVY
|  .| |  ..|| |||. .|.|||...| || |     ||| || .|   . |. .||.| |   ...||||.||. |....|..|      ||.|. |
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPKEMgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQ-VSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitanTKGSTPMLVHCSAGVGR
||...   .. .  .||. ..|| ...| | ... .     . |...|||.. |||.|||.||. |.   . |.|....     .. ....|||||||||
wplki..vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk....enhranivvhcsagvgr

TGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQE
||..| | ..| .. ||..||.. |....|..|...||   || .|..||.| .. |..|| .  | | |  | .
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 171-415 1.3e-74 245.4 In-house 3-239 (239) alignment 
Range on Protein: 171-415
Range on HMM: 3-239/239.0
AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEM
| |  ||||||. |||..|||||||| | .|||||| ||.|.||  |  |..||.|   ..|  ||||..|||  | .||.| ..|| | .|  |||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

GKsktFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQtvkhvheRITA-NTKGSTPMLVHCSAGVGRTGTFI
 |   .  . | ||  | |.|.. | . . ||   | | |.|.|.  ||| ||||| |...   .       .||  .  |. | ..||||||||||.|.
sk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.......kitkdslpgarpwvihcsagvgrtgafl

SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
 . .|| |  ..  |||| ... .|.||| ||||..||..|| |..|
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 420-717 2.4e-74 245.3 In-house 1-297 (298) alignment 
Range on Protein: 420-717
Range on HMM: 1-297/298.0
GNTDVPVSSFEAKLSSLQERNPLTQKLNIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDV
|||.. .....|.|. |.. .. ..  . ..||. ||. .  .  .  ..|  |.| .|||......... |  | .. .   .||||||||... ... 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQ
|.||| ||..|. | ||||..  . .||||..|  .||  . .|||.. . ..| ..||. | |.  .|...||....   .... .|.|.. . |  ..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWp.dk

KRPASLAPILHLVDAVSEcVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYA
  |.    .|.|.. |    ..     |....| .|.|||| | ||.|  |.. ....||.|| ||.||..|| .... .||. .|| . |... |....
gvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0051299 (Phosphotyrosine protein) phosphatases II 420-711 2.8e-74 245.5 In-house 1-287 (288) alignment 
Range on Protein: 420-711
Range on HMM: 1-287/288.0
GNTDVPVSSFEAKLSSLQernpLTQKLNIEQEFEILNQLTPPvgpQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDV
|.|...|....  .  |.    .... ....||| | .|.|.     ..|| ||.|..|||....|| ...| .| . .. ...||||||..... .|  
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKG-----PKKGTLTVKQFQLMGW
|.||| |||.|..| |||| .....|||||..|.  . . ||||||...|...|...| ..| |.  .||..|..|..      ... ..||..|. ..|
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnw

DgNQKRPASLAPILHLVDAVSECVRtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
  ..  | |. ..|... .| .. .  . .||.| || .|.||.|.|.|.. . | . .   ||... |||||  || |.....||  .|| ..||.|
p.dhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_PTPRD_pd Subfamily PTPRD 467-716 3e-74 245.6 In-house 40-287 (564) alignment 
Range on Protein: 467-716
Range on HMM: 40-287/564.0
FKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPN
..||  |||  |||. |... ...| .| .     ..|||||||.... |.  ..||| ||..|. | |||| . .| .||||..|  ..|  |..|||.
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

KDSVQFGPLKVSIISAETIrSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrTsQASGPIVLHCINGIGRSGVFAAIY
|.. ..| |.|.. . |.. .||..|.|..|   .. . .|.||. . |  ..  | | ...|.|.. |...  . . .|||| || .|.||.|.| .| 
kgtetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWP.dhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfivid

SAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEY
.  |.. ..  |||.| ||.||..|. |... .||. ..| ..|....... 
amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0045098 (Phosphotyrosine protein) phosphatases II 168-418 6.2e-74 244.2 In-house 25-273 (278) alignment 
Range on Protein: 168-418
Range on HMM: 25-273/278.0
KTVAMKPENKAKNRFKNIVAFDHSRVVletlkddphsDYYNANYIRDDkgKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPk
 |.|....|..|||.|.|...|||||.          || ||.||.    .|.|||.|.|    ..||||..|.... ..||.|. .|.|.  |  ||| 
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.

EmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV----SGGETRSVHQFHYQSWPDMGVPQYP--TTLISYTQTVKHVHERITANT-------KGSTPML
| |.|.|.|...|.|  .|...| ..|.| |  .    ...|.| |...|| .|||.||| .|  . ...... ........   .        ...|.|
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGVGRTGTFISLYCMLAQVieESRVDIFGFIQKMRKDRPN-MVQTADQYILIHTALVEAYM
||||||||||||.. .|.|| ..  |..||..  ....|. ||. .||. .||. .. .|.| ..
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0046845 (Phosphotyrosine protein) phosphatases II 447-715 1e-72 240.3 In-house 1-279 (284) alignment 
Range on Protein: 447-715
Range on HMM: 1-279/284.0
NIEQEFEILNQLTPPVGpQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA-GSTDYINASFLNTF-----IKKDVFLATQMPLPHTTGDIWRMVCD
..|.||| |..||...    ...| ||.|..|||....|| ...| .| . ..  ...||||||.....     ..|  |.|||.|||.|..| |||| .
gleeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

WRSPVIVMLNELDLQDK-SCAQYWPNKD-SVQFGPLKVSIISAETiRSDYVMRKFEIKGP--KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEC
....|||||.||.  ..  ||||||... ....|...| ..| |. ..||..|..|..    .. ..||..|. ..|  ... |.|....|.....| |.
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrel

VRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDS---SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
 . .  .|||| || .|.||.|.|.|.. . | .....    ||... |||||  || |.....||  .|| ..||.|..  
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPN9_pd Subfamily PTPN9 137-416 1.5e-71 235.9 In-house 5-289 (297) alignment 
Range on Protein: 137-416
Range on HMM: 5-289/297.0
NLVEHVEKKkaqDQDGFAHEFGLLPSDDGIAKT-VAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDF
.||..|..|   .. |  .|.  . .     .  ..... |  |||..... .|..||||.....|..||| |||..   | ||.|||.| |    ..||
elvayvkek...gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQT
||..|...|  .||.| ..| |. .|. |||.| ..|. || ..|.   .|| .|...||| .|.|  .|.|.|  | . |||| |||.  ..|.   ..
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VKHV----HERITANTKGS---TPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
|..      . .....||     |..||||||.|||||||.|   |... |.. ||..  ....|. |  ..|| .|| . . |..| 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0047943 (Phosphotyrosine protein) phosphatases II 439-710 4.1e-71 235.0 In-house 5-272 (273) alignment 
Range on Protein: 439-710
Range on HMM: 5-272/273.0
RNPLTQKLNIEQEFEILNQLTPpvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMV
...|...  ...||| | .|.|   .  ...| ||.|.||||....|| ...| .|    . |..||||||..... .|  |.|||.|||.|..| ||||
lekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

CDWRSPVIVMLNELDLQDK-SCAQYWPNKD---SVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAV
 .....|||||.||.  ..  ||||||..    |...|...| ..| || ..||..|..|..    . ..||..|. .||  ... |.||...|.....|
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielv

SECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
 .. ...  .||.| || .|.||.|.|.|.. . . ...   ||... ||.||  || |.....||  .|| ..||.
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0037934 (Phosphotyrosine protein) phosphatases II 169-415 1.3e-70 233.0 In-house 3-240 (243) alignment 
Range on Protein: 169-415
Range on HMM: 3-240/243.0
TVAMKPENKAKNRFKNIVAFDHSRVVLetlkDDphSDYYNANYIRDDKgkkTFIAAQAPNTASIND----FWRLIWQENVCSVVMVTNILEGGKDRCTVY
..|..|||. |||...|...|||||.|    ..  |||.|||.|.  .   ..|| |.| . ...|    |||..|.... ..||.|.  | |.  |  |
siallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPkemgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS-GGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITA--NTKGSTPMLVHCSAGV
||     ..|.|...|.|  .|...| ..|.| .. .. ...|| |...|| .|||.|||. |. |... . |. . |...   . ... |.||||||||
wp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFISLYCMLAQVieesRVDIFGFIQKMRKDRPN-MVQTADQYILIHTALVE
|||||.| .| || ..    .||..  ....|. ||. .||| .||. .. || |
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 133-419 1.6e-70 232.3 In-house 2-285 (290) alignment 
Range on Protein: 133-419
Range on HMM: 2-285/290.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDD-GIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLK--DDPHSDYYNANYIRDDKGKKTFIAAQAPNT
| | .. |.|....|. ..|| ..|. | | .   . ||.. ..|| .|||.|||  |  |..|  .    |   .| || || . | || .||.|.| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSG-GETRSVHQFHYQSWPDMG-VPQYPT
  . |||.|||||.|. .||.||| | ||..|  |||..  ..|..| ...||   |.... ..| |.||. .  |...||.|.. ..|.. | |... |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

TLISYTQTVKhvheriTANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
 |..... .|      |   .| |...||||..|||...|....  . ..  |  .|.|  ....|  .|..|||..|| .|.. ....  |
illvieemyk......tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0040438 (Phosphotyrosine protein) phosphatases II 446-714 2.4e-69 229.3 In-house 18-280 (317) alignment 
Range on Protein: 446-714
Range on HMM: 18-280/317.0
LNIEQEFEILNQLTPPvgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPV
  ...||| | .|...     .. | ||.|.||||.|..|| . .| .|   |.  ..||||||. ... .|. |.||| |||.|..| |||| .... |
talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLNELD-LQDKSCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRtsQAS
||||.||. |... ||||||.......|...| ..| |.  .....|..|...  .. ..||..|. .||.  .. | |. ..|....|| |. .  . .
ivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspdllldfleavreale..dpg

GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
||.. || .|.||.|.|.|.| . | . .   ||... ||.||. || .... .||  .|. ..||.|...
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0039614 (Phosphotyrosine protein) phosphatases II 435-714 2.7e-69 229.2 In-house 21-293 (297) alignment 
Range on Protein: 435-714
Range on HMM: 21-293/297.0
SLQERNPLTQKLNIEQEFEILNQLTPPvgpqaFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA-GSTDYINASFLNTFIK-KDVFLATQMPLPHTTG
 |. ......|  ...||| | .|.|.     .. | ||.|.||||....|| . .| .| ....   ..||||||..... . .. |.||| |||.|..
lllllekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DIWRMVCDWRSPVIVMLNELDLQDKSCAQYWPNKDSvQFGPLKVSIISAETiRSDYVMRKFEIKGpKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDA
| |||| .....|||||..|.  .. ||||||.. . ..|...|  .. |. ...|..|..|..  .. ..||..|| .||    . | ||. .|.....
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn.ngesrtvthfqytgwp.dhgvppslellleflel

VSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
| |...... .||.. || .|.||.|.|.|.| . | . .   ||... ||.||  || .... .||  .|. ..|. |...
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0036941 (Phosphotyrosine protein) phosphatases II 439-714 7.5e-69 227.6 In-house 6-281 (297) alignment 
Range on Protein: 439-714
Range on HMM: 6-281/297.0
RNPLTQKLNIEQEFEILnqlTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMV
 ..|...  ...||| |   .|   .  ...| ||.|..|||....|| ...| .|    . ...||||||.....  |  |.||| |||.|..| ||||
lekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv

CDWRSPVIVMLNELDLQDK-SCAQYWPNK--DSVQFGPLKVSIISAETI-RSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAV
 .....|||||.||.  ..  ||||||..  .|...|...|  .| |..  .||..|..|..   .. ..||..|. .||.   . | | |..|.....|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielv

SECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMI---TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
 .. . .  .||.. || .|.||||.|.|.. . . .    .   |||.. || ||  || ......||  .|| ..|. ||..
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 171-415 2.9e-68 224.8 In-house 15-262 (270) alignment 
Range on Protein: 171-415
Range on HMM: 15-262/270.0
AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIR-DDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEM
     .|. ||...|.   ..||.||.|..|... |.||||.|  |. ||..|||..|  .....|||.||.|.| ..||.|.. | |...| .|||.| 
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

GKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHER--ITANTKGSTPMLVHCSAGVGRTGTF
... ..   ..| ....|  .. ...  ..  . ||.| .  |.|..||| |||. . . .| .| .| ...    . ... ..|.|||||||||||||.
kekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

ISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
| |  ..  . |...||.   |...||||...||. .|| ... |.||
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 156-415 2.2e-67 222.0 In-house 10-266 (274) alignment 
Range on Protein: 156-415
Range on HMM: 10-266/274.0
EFGLLPSDDgiAKTVAMKPENKAKNRFKNIVAFDHSRVVLET-LKDDPHSDYYNANYIRD-DKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNI
||  ||..    .   . . .. |||.|.|.  ..|||.||.   .|. |.| |||||.  |. .|...|.| | .  ..||||.|.||.|  .||.|..
eflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl

LEGGKDRCTVYWPKEMGK--SKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGgeTRSVHQFHYQSWPDMGVPQYPTTLIsytQTVKHVHERITANTKGST
 |  ...|.||.|.. .   |...|..|.| . | |  |.  | | .|...   .|||. . | .|||. .|. ..||.   ..|..|.|  .....  .
keaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantll...dlvleveesreeenakla

PMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
|..||||||.|||| ||.    . |. ||. ||... . ..| ||  ||||..|| ||| ||..
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 141-437 4.7e-67 221.1 In-house 12-256 (392) alignment 
Range on Protein: 141-437
Range on HMM: 12-256/392.0
HVEKKKaqDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIW
 |||..      |..||  ||. |   .||| |. |. |||.|||. .| .||.|| . | |.|||.|| ||.  . .|..||.|.||.||..||||...
fveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

QENVCSVVMVTNILEGGkdrctvywpkemgksktfggievklrtieefsdhvhrvldvkqvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVH
||||....|||.. ||                                              | ..|.| |||.  ||| .||.. ..|. . . ||  .
qenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf

ERITantkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQ
 . |       |...||||||||||  ||. ...|.  .   ||.| |. ..|. || |||| .|| .|. |..|  .  || .||  |  .|. |.
Gqyt......hpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
DSPc_SM00195 448-711 9.4e-67 220.5 In-house 2-263 (263) alignment 
Range on Protein: 448-711
Range on HMM: 2-263/263.0
IEQEFEILNQLTPPVgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
...||| |.. |.|     .. |  ..| .|||. |.||....|  | .. .  ..|||||.....  ||  . |||.|||.|  | |||| . ....||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNELDL-QDKSCAQYWPNK--DSVQFGPLKVSIISAETIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSqaS
||.| .  . . |..|||..  .. .|| ..| ... |. ......|..|..  . . | .|.|.|  .|  . . | |  ..|.|. || .. .||  |
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..s

GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|||| || .|.||.|.|..| .. .|. ... ||||. ||.|| .||.|... .||...|| ..||.|
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 448-711 9.4e-67 220.5 In-house 2-263 (263) alignment 
Range on Protein: 448-711
Range on HMM: 2-263/263.0
IEQEFEILNQLTPPVgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
...||| |.. |.|     .. |  ..| .|||. |.||....|  | .. .  ..|||||.....  ||  . |||.|||.|  | |||| . ....||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNELDL-QDKSCAQYWPNK--DSVQFGPLKVSIISAETIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSqaS
||.| .  . . |..|||..  .. .|| ..| ... |. ......|..|..  . . | .|.|.|  .|  . . | |  ..|.|. || .. .||  |
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..s

GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|||| || .|.||.|.|..| .. .|. ... ||||. ||.|| .||.|... .||...|| ..||.|
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 133-423 1.1e-66 219.8 In-house 2-284 (287) alignment 
Range on Protein: 133-423
Range on HMM: 2-284/287.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPS--DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLEtlkdDPHSDYYNANYIRDDKGKKTFIAAQAPNTA
|.| .. | |.| .|. ..|| . | .| .  ..    |... ..|| |||...|.  |  ||.|.    . | || || .|   | || ||.|..| . 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS-GGETRSVHQFHYQSWPDMG-VPQYPTT
 . .||.||...||  .||...  |  .. |  |||.|  || ..|  ...|   |  .. . | |.||. .  |....|.|... .|.. | |... | 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LISYTQTVKhvheriTANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTD
|.   . .|      |   .| |...||||..|||...|..    . .. .|  .|.|  ....|  .|..|||..||. |  ...|   |..| 
llvieemyk......tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 174-415 4.5e-66 217.5 In-house 1-237 (237) alignment 
Range on Protein: 174-415
Range on HMM: 1-237/237.0
PENKAKNRFKNIVAFDHSRVVLETLKDDphSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKeMGKS
.|||.|||. ||||.|||||||.    .  ||| ||.|...  |  |..|||| |  .| .|||...|||.   .||.| ..|| . .|  |||.   . 
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqp

KTFGGIEVKLRTIEEFSDHVHRVLD-VKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVkhvHERItANTKGSTPMLVHCSAGVGRTGTFISLY
...| . | |.  |||||.  | |  .|...  | | .||... |||| ||||. ..|. . . .    .|       |.| ..|||||||||| |. . 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni...inrs.phvsesgpwiihcsagvgrtgiflvid

CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
.|| |  |.  |||. ... . .||| ..|| |||..|| ...|
amlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 424-718 7.4e-66 217.4 In-house 2-288 (318) alignment 
Range on Protein: 424-718
Range on HMM: 2-288/318.0
VPVSSFEAKLSSLQErnplTQKLNIEQEFEILNQLTPPvgPQAFKAaGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLAT
..|. .| ..  |.|    . .|....|.| |.. .    . ..|.   |.|  |||. |.|. .. |  | .. .  ..|||||.... . .|  ..|.
isvedleshvrrlre....sGelllseeyerlsrseet..vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDgNQKRPA
| |||.|  | |||| .  | ||||| ..  . |  ...|||.|.| ..| |.| . .  .  ||||.|.|...  . . . .|.|..   |  ..  |.
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeeve.lsdyvlrefkvtrteeeesrqvrqyhytsWp.degvpe

SLAPILHLVDAVSECVRtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
| | .|.||  ||.  . ..  |||| ||  |.|| ||| |. .  |..  .. ||.|| ||.|| .|. |.   ||| ..|. . |... .| ...
sgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0045450 (Phosphotyrosine protein) phosphatases II 436-711 7.7e-66 218.2 In-house 17-305 (307) alignment 
Range on Protein: 436-711
Range on HMM: 17-305/307.0
LQERNPLTQKLNIEQEFEILNQLTPPVgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA-GSTDYINASFL--------NTFIKKDVFLATQMP
|. ...|. .  ...||| |...|... .  ...| ||.|.||||....|| . .| .| . ..  ...||||||.         .....|. |.||| |
lvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSV-QFGPLKVSIISAETiRSDYVMRKFEIKG--PKKGTLTVKQFQLMGWDgNQKRPAS
||.|  | |||. .... |||||.||.  ..  ||||||..... ..|...|  .| |.  ..|..|..|..   ... ..||..|.  ||  ... | |
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwp.dhgvpps

LAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSS---VDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
....|.....| ....... .||.. ||  |.||.|.|.|.| . . . ..     ||... ||.||. || .... .||  .|| ..|. .
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0043336 (Phosphotyrosine protein) phosphatases II 442-710 9.7e-66 217.4 In-house 16-277 (278) alignment 
Range on Protein: 442-710
Range on HMM: 16-277/278.0
LTQKLNIEQEFEILNQLTPpvgpQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDW
|. |  ...||| |.. ..      .. | ||.|.||||....|| . .| .|   |.  ..||||||..... ... |.||| |||.|..| |||| ..
lnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

RSPVIVMLNELD-LQDKSCAQYWPnKDSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRt
....||||.||. |. . |||||| ..|...|...|  .. |.  .||..|..|..   .. ..|| ... .||   .. | ||...|... || |... 
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale.

sQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
   .||.. || .|.||.|.|.|.| . | . .   ||... ||.||  ||..... .||  .|| ..||.
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 475-707 6.4e-65 214.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 475-707
Range on HMM: 1-234/235.0
NIDKNRFPNVLPMEKNRPCLvtKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWP--NKDSVQF
| .|||....||..|.|  |  ||. |..|||||...... .|  |.|||.||..| .| |||| . .. |||||..|.  ... ||||||  ...|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLKVSII-SAETIRSDYVMRKFEIKGPKKGT--LTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrtSQASGPIVLHCINGIGRSGVFAAIYSAAE
| .|| .  . ... ..|..||.|.|  |. .   .|||... .|  ... |.|  ..|.|...| .    .. |||.| ||..|.||.|.|.|.  . |
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

KMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMA
.. ....||..| ||.||..||.|..|..||  .|. ..
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 475-707 6.4e-65 214.2 In-house 1-234 (235) alignment 
Range on Protein: 475-707
Range on HMM: 1-234/235.0
NIDKNRFPNVLPMEKNRPCLvtKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWP--NKDSVQF
| .|||....||..|.|  |  ||. |..|||||...... .|  |.|||.||..| .| |||| . .. |||||..|.  ... ||||||  ...|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLKVSII-SAETIRSDYVMRKFEIKGPKKGT--LTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrtSQASGPIVLHCINGIGRSGVFAAIYSAAE
| .|| .  . ... ..|..||.|.|  |. .   .|||... .|  ... |.|  ..|.|...| .    .. |||.| ||..|.||.|.|.|.  . |
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

KMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMA
.. ....||..| ||.||..||.|..|..||  .|. ..
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN23_pd Subfamily PTPN23 138-415 1.6e-64 212.5 In-house 2-278 (288) alignment 
Range on Protein: 138-415
Range on HMM: 2-278/288.0
LVEHVEKKKAQDQDGFAHEFGLLPSDDG---IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIRDD-KGKKTFIAAQAPNTASIN
|||....|. ... .. ..| .| ...      ...|.   .  |||...|. .||.||.|.  ||    || || ...|   |  .|||.|||   ..|
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstln

DFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYT
|||...... .  .||...  | || ..  |||.. |....|| ..| |.  .| . ||.||| ..  .  ...||   ...|||..|||. | ||. . 
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

QTVKHVHERITAntKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESR-VDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
. |.. .|      |  ||..|||||||||||.|  .|. .... ..   .||   ....|..| .|||. .|.     | .|
devesayeavqr..ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 472-718 3e-64 211.6 In-house 6-250 (250) alignment 
Range on Protein: 472-718
Range on HMM: 6-250/250.0
LPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKSCAQYWPNKDSVQF
 |.| .|||. ....... |  | ..     .||||||||... ... |.||| ||..|. | |||| .  | .||||..|  ..| . |||| . . ..
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaeky

GPLKVSIISAETiRSDYVMRKFEIKGPKKG-TLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAAEKM
| ..||. | |.  .||..||. .   ||    .|.|.. . |  ..  |.    .|.|.. |    .    ..|....| .|.|||| | ||..  |..
Gdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWP.dkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

ITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
 ..  ||.|. .|.||..|| ..|| .||. .|| . .... ...||.
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 445-715 1.7e-62 206.3 In-house 22-289 (319) alignment 
Range on Protein: 445-715
Range on HMM: 22-289/319.0
KLNIEQEFEILNQLTPPvgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSP
.  .|.||. |.. ..      |. |  . | .|||..|.|.... |  | .  .  ..|||||||.... ... |.||| || .|. | |||| . .| 
etllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

VIVMLNELDLQDK-SCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIkGPKKGTL---TVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTS
..|||..|  . |  . .|||... ...| | | . . |   .||..||...  .|.. .   .||.|| . |  ... | ..  .|.|.  . . .. .
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeee.ledyiirklkl.nkkssevetRevkhfqyteWp.dhdvPekatslldllkrirksrekt

QaSGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD-E
| ||||| || .|.|| | | ..  . |..  .. .|.|. |.|||. |. |..  .||...|| . |... .| |
q.sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
0040439 (Phosphotyrosine protein) phosphatases II 470-711 2.4e-62 206.1 In-house 6-247 (249) alignment 
Range on Protein: 470-711
Range on HMM: 6-247/249.0
AGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQ-DKSCAQYWPNKDS
| ||.|.||||.|..|| . .|..|   ..   .||||||.....  |. |.||| |||.|..| |||. .... |||||..|.    . ||||||...|
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

VQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAA
...| ..|  .| |.  .||..|..|..   .. ..||...|  .|   .. | |....| ...|| .....   .||.. || .|.||.|.|.|.| . 
leygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

EKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| . .   ||... || ||  || .... .||  .|| ..|. .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 447-710 8e-62 203.9 In-house 22-279 (288) alignment 
Range on Protein: 447-710
Range on HMM: 22-279/288.0
NIEQEFEILNQLTppvGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
....|.. | .|      .. .|. |. | .|||..|.||.. .|  |    |  ..||||||...   || ...||| ||..| .| |..| . ..  |
gfseeynsLaale...ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti

VMLNEL-DLQDKSCAQYWPNKDS-VQFGPLKVSIISAETIrSDYVMRKFEIKgPKKGTLTVKQFQLMGWDGNQkRPASLAPILHLVDAVSECVRTSqaSG
|||.|| . ... | .|||..|  ...| ..| ... ..   |.|.||....  ||. |...|.| ..|  ..  |.| ||.|.|.. |         .|
vmltelveggktkCeeYWPdadkpknyGsvtvtlveskel.edfvlrkllle.kkkteleitqyqylaWpdhg.vPeskapllellrqvkvanqad..tg

PIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
||. || .|.||.|.| |.  . ... ..  .|..  |..|| .|..... . ||  .|| ... .
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN3_pd Subfamily PTPN3 164-419 9.1e-62 203.5 In-house 29-277 (280) alignment 
Range on Protein: 164-419
Range on HMM: 29-277/280.0
DGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLEtlkDDPHsDYYNANYIRDDKGK----KTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKD
 |.| ..| |||| .|||...|...|. || |.   . .  || ||||.  .       . .||.| | . . .|||...|....  .||.|...| |. 
pglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

RCTVYWPKeMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSA
.|  |||. .... ..|...||..  .| . .| | | .|. .  | |...|. | .||| |||. .. .......|....      .  ..|..|||||
kChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsa

GVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
|.|||| .| |   || . ..  | .   ...||  | ..||||.|| ..  |....|. 
GigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_PTPRK_pd Subfamily PTPRK 472-708 9.1e-61 200.4 In-house 40-275 (314) alignment 
Range on Protein: 472-708
Range on HMM: 40-275/314.0
LPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSVq
   | .|||. ..|.... |. |.|  .  |.|||||...... .   |..|| ||..|. | ||.| | ..  ||||.||  .    | .|||.. .| 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

FGPLKVSIISAETiRSDYVMRKFEIKG---PKKGTLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTsqASGPIVLHCINGIGRSGVFAAIYSAA
.|..|| ....|.  ...|.| | ..    ..... .|.||| .||    . | |   .|.||  | .        |.||.|| .| ||.|.| || .  
ygdikvelvetel.laelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivl

EKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
. . ... ||.|. || ||.... |.|  .||  .|. . |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 474-711 1.6e-60 199.7 In-house 50-285 (297) alignment 
Range on Protein: 474-711
Range on HMM: 50-285/297.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKkdVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKSCAQYWPNKDSVQFGP
 |..|.|. |.||....|  |   ..  . ||.||||.... .   ...|||| . |  | |.|| | .  .|||||... .||.||.||..| ...|| 
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGd

LKVSIISAETiRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDGNQ-KRPASLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAAEKMI
. | . | .  |. .. |..|..  | | .  |||.| . |  .. .|  | . .|.|.. | .   . .|.||...||..|.|| ||. .| |   .. 
vsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsq.naegPllvhclaGvGrtgvlltidsvvaeak

TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
 . .||||. ||.|| .|| ..   .||.  |. . |.. 
rekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 138-432 2.4e-60 199.2 In-house 7-294 (439) alignment 
Range on Protein: 138-432
Range on HMM: 7-294/439.0
LVEHVEKKKAQDQDGFAHEFGLLPSDDG---IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASIND
. ||||| . ..|. | ..|  . | .       ..| .  ...|||.|...||||.||.|. .   ||| |.|||||.    .| .||.|.|.  . .|
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettdd

FWRLIWQENVCSVVMVTNILEGGKdrctvYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDV--KQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
||||......  .||.||..|  |     ||| .  .   .| | |.     |. ..| | . |  .. ..   |.| |||| .|||  ||   . .. .
fwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

TQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAK
 ....        ...   |..|||||||||||| |.|   | |.  | .||| | .. .||.| .|||.  ||..|. |..|  . |.. | .  |. .
lrainsan.....dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
subfamily_PTPRA_pd Subfamily PTPRA 466-711 3.3e-60 198.7 In-house 49-296 (330) alignment 
Range on Protein: 466-711
Range on HMM: 49-296/330.0
AFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWP
....|    | .|||..|.|| . .|  | .|    ..|||||||.. . .|| |.|.| |. .|  | |||. ...|  |||| ||.  ... ||||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

NKDSVQFGPLKVSIiSAETIRSDYVMRKFEIK-----GPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGV
.. .| .| ..|..   ||.  || .||| ..       .| .  |.|| . .|  .   |.    .|.|. .| ..    | .||||.||  |.||.| 
deGlvtyGnirvev.edetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkkl..nqqsagpivvhcsaGvGrtGt

FAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| .. .  |.. ..  ||.|. |||||..|| |. .  ||  .|. . ||  
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
0042113 (Phosphotyrosine protein) phosphatases II 470-711 4e-60 198.6 In-house 4-244 (245) alignment 
Range on Protein: 470-711
Range on HMM: 4-244/245.0
AGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELD-LQDKSCAQYWPNKDS
| ||.|.||||....|| . .| .|   |.   .||||||. ...  .. |.||| |||.|..| |||. .... .||||.|.. |. . ||||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

VQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAA
...| ..|  .| |.  .||..|..|..  ... ...| ... ..|.  .. | .|. .| ....| ....   ..||.. ||  |.||.|.|.|.| ..
ltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylml

EKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| . .   |.... ||.||  || .... .||  .|| ..|..|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPN13_pd Subfamily PTPN13 169-416 4.8e-60 198.1 In-house 29-268 (273) alignment 
Range on Protein: 169-416
Range on HMM: 29-268/273.0
T-VAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsdYYNANYIRDDKGKKTF--IAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYW
. |. | |||.|||..|.. .|..|| |.         | ||..|.   ||...  ||.| |   ...|||...|. ..  ..|||.  |.|| .|  ||
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PKEMGKSKTFGG-IEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHEritantkGSTPMLVHCSAGVGRT
|....|. .  . .||.|  ... .. | | | ||..  ||.| | .... .||| |||. .. |. . . |.....        ..|..||||||.||.
PesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.......dagPivvhcsaGiGrs

GTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
||.|... .|  .  .  .|.   ..|.|. |  .||| ||||... |..|.
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Ptp69D_pd Subfamily Ptp69D 447-714 1.3e-59 196.8 In-house 23-290 (307) alignment 
Range on Protein: 447-714
Range on HMM: 23-290/307.0
NIEQEFEILNQLtppVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
 ...|.| |..      ..  |..    |  |||.... . .|.|  | .     ..|||||||.... .|  |.| | |.  | || |||. .  . .|
glakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLNELDLQ-DKSCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGPK------KGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRT
||| .|. . .| ||.|||. | ||.| . | ..| |.  |||..|....   |      . .  | |.. .||. . | | .   .|.|.. | |  ..
vmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

SqaSGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
.   .|||.|| .| ||||.| |. |  ... .. .||||. || || .|. ...| .||. .|  ...|... |
n..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
0045098 (Phosphotyrosine protein) phosphatases II 456-713 3.4e-59 195.8 In-house 14-275 (278) alignment 
Range on Protein: 456-713
Range on HMM: 14-275/278.0
NQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPClvtkgeagstDYINASFLNTFikKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNE-LDL
 .| ..  |. .  | .. |.||||....|| . .| .          ||||||.....  .. |.||| |||.|. | |||. .....|||||.| ..|
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

QDKSCAQYWPNKDSVQFGPLKVSIISAETIrSDYVMRKFEIKG-----PKKGTLTVKQFQLMGWDGNqKRPASL--APILHLVDAVSECVR---------
. . ||||||...|...|...| ..| |.. .||..|....       .   ...|.......|. .   | .   ...|.|.. . |...         
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllss

--TSQASGPIVLHCINGIGRSGVFAAIYSAAEKMitDSSVDIFQSVKRLRANRPS-MIESVDQYSICYEGMAEYMKKF
  . . .||.. ||  |.||.|...|.|   | .  .. ||... || ||  ||  .... .||  .|| ..|. ...
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 460-711 3.4e-59 195.2 In-house 31-278 (315) alignment 
Range on Protein: 460-711
Range on HMM: 31-278/315.0
PPVGPQafKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-S
|.. .|  ..|  . |  |||. |.||....|  |    .    ||||||..... .   ..|.|.||. .  | |||| . .   |||..... .|| .
Pdiyrq..rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPN--KDSVQFGPLKVSIISAETIrSDYVMRKFeIKGPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGR
|.||||.   |||.|| .||...| |.  .| |.||. .    . . || |||. .|  ..  .  .. .|.|. .|       .   ....||  |.||
crqywPdrkadsvefGsikvellslead.tdgvarkl.vtrkseesrtvtqfqftewP.dkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGr

SGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.||. .| .  ...   .|||.|. || |||.|| .. . ..|.  |. . |...
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRB_pd Subfamily PTPRB 423-712 2e-58 192.7 In-house 6-287 (293) alignment 
Range on Protein: 423-712
Range on HMM: 6-287/293.0
DVPVSSFEAKLSSLQERNpltqKLNIEQEFEILNQLTppvGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLA
.. ...||. ........    .|.. .|.| |...      || ||| |..| .|||. |.|| ...|  | .  .  ..|||||.... .  .  |.|
piklekfeehvkkmkads....dlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefia

TQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNK-DSVQFGPLKVSIISAETiRSDYVMRKFEIKGpKKGTLTVKQFQLMGWDgNQKRP
|| |||.|. |.|||| . .| .|||| .|  . |  | .|||.. ..|..| .||.... |.  .|.|.|...|.  .| . .|.|.. . |  .   |
tqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek.ekeerkvrqyhftsWp.dhgvP

ASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
 . ...|..| .| | ........||| ||  |.||.|.| |.    ... ..  ||||  | .|| .| ... ...|| . .. . ....|
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 445-708 9.8e-58 190.9 In-house 33-289 (319) alignment 
Range on Protein: 445-708
Range on HMM: 33-289/319.0
KLNIEQEFEILNQLTPPVGPQAFkaAGLPANIDKNRFPNVLPMEKNRPCLV-TKGEAGStDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRS
. ..| ||  . .|...   |.|  | |. | ||||. |.|. .||.  |  . || .| |||||||.. . .|| ..|.| ||. |  | |||. ....
ltklevefrracklgvnladqtf..anldqnkdknriinilafdknvvklerliGeefs.dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

PVIVMLNeldlqDKSCAQYWPNKDSVQFGPLKVSIISAETIRSdYVMRKFEIK--GPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQ
  ||.|       . |.||||.|  .. .  ||.. | |     ||.|..|.   | .|.   ..|| ..||  ..  | . .... ||. |.   .  .
stivllt.....kdkcsqywplkivikeerfkvkvdsveetae.yvvrdielsedgkekdirkitqfhflGwp.dvGvpdypsdlmrlvkkvrhltsken

ASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
   .||.||  |.||.||. ..    ..|  .. ||... |. || .|. ..... || ..|  . |
hranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 143-419 3.7e-57 188.3 In-house 7-294 (301) alignment 
Range on Protein: 143-419
Range on HMM: 7-294/301.0
EKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKD--DPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIW
... |. ...|....  | . .    || .. |||| ||||||. .|. |..|.. ..    . .| ||.|| . . || |||||.|    . |||||||
thvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

QENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGE---------------TRSVHQFHYQSWPDMGVPQY
|| . |.|||||  || |..|. |||.   .|..|| ..|.|     . |.| | | ||   | .               ...| |..  .||. || . 
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

PTTLISYTQTVKHVHERItantkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALvEAYMS
| | .   . | |   .|     |  |..||||..|.|.|...|.   | |.  |  ||.|. .. .|. .| .|.| .||. |. .. . |..
prtvLqviddvihrqqki.....gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmylq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 448-714 3.9e-57 188.7 In-house 24-287 (305) alignment 
Range on Protein: 448-714
Range on HMM: 24-287/305.0
IEQEFEILNQLtppvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
.|.... | ..     .....     ||  |||. .. .....|  | .| . . .||||||..... .|. ....| ||..|  | ||.. . .  .||
leaqykslyee.....eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLNELDLQD-KSCAQYWPNKDSV--QFGPLKVSIISAEtIRSDYVMRKFEIKG--PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQa
|| .|  .. . | ||||.. .   .||...| . | .   |||..||..|     .| . || |.||  |  ..  | . . .|.|.. | .  . .. 
mltklveggkdkCrqYWpesktekkefgefsvelksek.tasdyieRklkisiededkesrtvlqyqltdWP.dhGvpqfatsllslikrvqkdqkkdk.

SGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
  |.. || .|.||.||| |.  | |.. .. .||.|. .|.|| .|. |... |||  ... ..|... .|
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 474-711 7.4e-57 187.6 In-house 42-277 (515) alignment 
Range on Protein: 474-711
Range on HMM: 42-277/515.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKS-CAQYWPN--KDSVQ
 |  |||. |.||....|  |    ..   ||.|||....|     ..|.|.|.. .. | ||.| . .   |.|...|  .||. |..|||.   |||.
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

FGPLKVSIISAETIrSDYVMRKFEIKGPKKgTLTVKQFQLMGWDGNQKrPASLAPILHLVDAVSEcvRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKM
|| .||...| |.  .. . ||...   .. . || ||.. .|  .   |     .| |. .|     ..| . |...||  |.|| ||. .| |   ..
fGsikvelvsleac.tggikrkltvlkgdd.srtvtqfhfteWPdkGv.pkhtssllklikevka..dhgqythpliihcsaGvGrtGvvisidsvvaha

ITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
 |  .||.|. |. .|..|| ..   .||.  |. . |...
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN14_pd Subfamily PTPN14 167-415 1.5e-56 186.6 In-house 40-294 (300) alignment 
Range on Protein: 167-415
Range on HMM: 40-294/300.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDpHSDYYNANYIRDDKG--KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVY
  ..|  |||. |||||... ....|| | . |.. ...| ||  |.   |  ....|.||.|    ..|||...|...|  .||.|.. |.||...  |
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPKE--MGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITANTK---GSTPMLVHCSA
.||.    |. .||  .|  .  |. .  . . | .| .  .| |.|. . |. ||| |||. ... .|| . |. | .. . ...    . |.||||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
||||||  |    ..| .  . ..||   ....|. |  .|||  ||  ....|..
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 466-716 1.6e-56 186.3 In-house 37-289 (290) alignment 
Range on Protein: 466-716
Range on HMM: 37-289/290.0
AFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA--GSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQY
. . .  . |  .||| |... . ||  |  ...    . .||||.... . .|  ..||| |...|  | |... . ....|||| .  . . . | ||
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WPNKDSVQFGPLKVSIISAETIRsDYVMRKFEIKGPKK--GTLTVKQFQLMGWDGNQKRPASlAPILHLVDAVSECVRTSQaSGPIVLHCINGIGRSGVF
||..|. ..|. .. ... ||.  .|. ||.|.|  ..   . .|.|.|.  || . | ..  . ||...  . .  | .   ..||.|| ...|||.||
Wpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnp.qtillvieemyktqrkrg.ntsivvHCSdtvgrsavf

AAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEY
 |.. . .|. |.  .|.|| .|..|  .| ....|.|| . .. . .|...|. |
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 168-424 2e-56 186.0 In-house 25-273 (283) alignment 
Range on Protein: 168-424
Range on HMM: 25-273/283.0
KTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIR---DDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVY
 ..|.  ||| |||...||. |  || |...      || || .|    ..| .| .|.||.|    . |||.....|.....||.|.. |. . .|. |
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPKEmGkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV-SGGETRSVHQFHYQSWPDMGVPQYPTTLISYtqtvKHVHERITAntKGSTPMLVHCSAGVGR
|||. | |. .|   | ||        . . | ...  |  .|  .  . .. | ..|      .|. .      |    |   .  .|..||||.|.||
WPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf....nkvislqte..skkgPivvhCstgiGr

TGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDV
|..||.. . . ..  || ||.|  .. ||..|. .||| ||| |.|.. .|  . |.|..
tavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 451-708 2e-56 186.6 In-house 3-253 (284) alignment 
Range on Protein: 451-708
Range on HMM: 3-253/284.0
EFEILNQLTPPVGPQAFkaAGLPANIDKNRFPNVLPMEKNRPCLV-TKGEAGStDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML
||  . .|...   |.|  | |. | ||||. ..|. .||.  |  . || .| |||||||.. . .|| ..||| ||. |  | |||. . ..  ||.|
efrracklgvngtdqtf..anldqnkdknrighilafdknvvklerliGeefs.dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll

NeldlqDKSCAQYWPNKDSVQFGPLKVSIISAETIRSdYVMRKFEIK--GPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIV
      .. |.||||.|  .. .  ||.. | |     ||.|..|.   | .|.  ...|| ..||  .. .| . .... ||. |.   .  .   .||
t.....kdkcsqywplkivikeerfkvkvdsveesee.yvvrdielsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhraniv

LHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
.||  |.||.||. ..    ..|  .. ||... |. || .|....... || ..|  . |
vhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN1_pd Subfamily PTPN1 167-418 4.3e-56 184.8 In-house 23-272 (290) alignment 
Range on Protein: 167-418
Range on HMM: 23-272/290.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
  ..| .|||...||....  .||||..||  .     || ||. .  .. |. .| .| | .  .. ||...|...  .|||. ...| .. .|. |||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

KEMG-KSKTFG--GIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVheriTANTKGSTPMLVHCSAGVGR
..   |. ..    ..||| . |. | .. |.|......  |||.. .||| .|||.|||. |...... . |..      . ..   | ..|||||.||
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres....GslssdvGpavihcsaGiGr

TGTFISLYCMLAQVIEESR---VDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
.|||. . ..|... ..     |||   . ..|| |  ..|||||  . ..|..|   
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
0037934 (Phosphotyrosine protein) phosphatases II 469-709 1.4e-55 183.9 In-house 4-241 (243) alignment 
Range on Protein: 469-709
Range on HMM: 4-241/243.0
AAGLPANIDKNRFPNVLPMEKNRPCLvtkgeAGsTDYINASFLNTFiKKdvFLATQMPLPHTTGD----IWRMVCDWRSPVIVMLNELD-LQDKSCAQYW
 | ||.|..|||....||.. .| .|      | .|||||.. . . ..  . |||.|||.|. |     |||. .... |||||.||. |. . |||||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PnkDSVQFGPLKVSIISAETiRSDYVMRKFEIKG--PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRT------SQASGPIVLHCINGIG
|  ..|..|...| ..| |.  .||..|.....   ... |..| ... ..|   .. | | ...| ..|.| |...          .||...||  |.|
p..gevtygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RSGVFAAIYSAAEKMitdsSVDIFQSVKRLRANRPS-MIESVDQYSICYEGMAEY
|.|...|.|   ...    .||... ||.||. ||  .... .||  .|| ..|.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 469-712 3.4e-55 182.0 In-house 34-279 (290) alignment 
Range on Protein: 469-712
Range on HMM: 34-279/290.0
AAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYWPNK-
|.  . |. |||. ..|| .|.|  | .. |    |||||.|..   .|  ..|.| |||.|  | |||. . .  ..||. .|..|. | |..|||.. 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

-DSVQFGPLKVSIISAETIRSDYVMRKFEIKGPkKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRtsQASGPIVLHCINGIGRSGVFAAIYS
 ....||...|. .. ...  |...| ....   | . .|.||. . |  .. .|.|  ..|.|...| |  .  . . |.|.||  |.|| |.  ||  
eeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWP.DhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidy

AAEKMITD---SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
. | . ..   ...|.|. | .|| .|.... . .||.. |. .||...|
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_CG7180_pd Subfamily CG7180 447-711 1e-54 180.2 In-house 14-291 (296) alignment 
Range on Protein: 447-711
Range on HMM: 14-291/296.0
NIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
. . |.. . .||| .     ...    |..||| ..|.| ..||. | . .   ..|||||.. ..|.||  .. |..|  .| .. ||.| |  .  .
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VMLNELDLQDKSCAQYWPNKDSVQFGPLKVSIISAETIrSDYVMRKFEI-----------KGPKKGTLTVKQFQLMGWDGNQKRPASLAPILHLVDAVSE
|.| .   . | . .|||||   |.|.. | |.. ..  .. ..|.| .           |. |  | .||.|||  |. ..| | | . ...|.  |  
vvLtktfdfakmypsywpnkskeqygeifveiveekqy.anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

CVRTS---QASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
 ..     .  ||.| .. .| .||||. ||  . |... .  ||.|. ||.|| .|| ..|.|..|  .|. . |.. 
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 435-718 2.1e-54 179.5 In-house 9-286 (287) alignment 
Range on Protein: 435-718
Range on HMM: 9-286/287.0
SLQERNPLTQKLNIEQEFEILNQLTPPvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVtkgeAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDI
 . .... . . . .. | .|.|.|    ..    .  . | ||||. ..|. ...|  |         |||||.|.... .|  |.... |. .|  . 
efvakghakgnegfknqftvleqvtqr..edevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVCDWRSPVIVMLNE-LDLQDKSCAQYWPNKDSVQFGPLKVSIISAEtIRSDYVMRKFEIKGPK--KGTLTVKQFQLMGWDGNQKRPASLAPILHLVD
|... | . ..|||| .  . ... | ||||...|| .|. ...... | . ..|..||.|.|  .  . ...|||.|.  || . | .   . .| . .
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

AVSECVrtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
 . .     .. ..|| || ...|||..| |.  . .|  |.  .|.|| .|. |  .| ..  |.||   .. . ||.. |. |..
myktqr..krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_PTPRN_pd Subfamily PTPRN 164-415 4.6e-54 178.1 In-house 44-290 (297) alignment 
Range on Protein: 164-415
Range on HMM: 44-290/297.0
DGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCT
.  .|.|| ...|  ||| |.....||||| |..  .. .||| ||  | |.   . ..||.|.| .... |||...|.. |. .|..|.. | |  .|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

VYWPKEmGkSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantkGSTPMLVHCSAGV
 |||.| | |....  ||.| .   .. |.. | . .|..   |||.| |||. |||..|||  . .|. . . |   .         |.|..||||.|.
rywpde.G.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG......rscpivvhcsdGa

GRTGTFISLYCMLAQVIEES-RVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
||||..| .  .|....    ..||   ....| .||..|.| ||. .. ||..|
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPRG_pd Subfamily PTPRG 424-711 2.5e-53 176.2 In-house 1-288 (563) alignment 
Range on Protein: 424-711
Range on HMM: 1-288/563.0
VPVSSFEAKLSSLQERNpltqKLNIEQEFE-ILNQLTPPVGPqaFKAAGLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTDYINASFLNTFIKKDVFL
|||. |.  ..||   .    .  ...||| . .. ..   .   ...  | |  |||  |...... |  |    |. .. |||||.... . |.. |.
vpvkefakhvaslhadg....digfseefealqsetiskdld..aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafi

ATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSVQFGPLKVSIISAETIrSDYVMRKFEIKG-----PKK--GTLTVKQFQLMGW
||| ||..|. | |||. . .. .|||. .| . . . | .|||. .|...| |.| .|. |.. . | .|.. ||       |.    ..|.|..   |
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevl.alytvrtlviknlklkkkkqcdteklvrqyhytkW

DgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
  ..  | . .| |  |   |    . .. |||| || .|.||.|.. .. .  ... ....|..|. .|..||.|. .... .||   .. . | ..
P.dhgvPehslpvLifvkkssaa..nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_CG7180_pd Subfamily CG7180 170-421 5.1e-53 174.6 In-house 36-294 (296) alignment 
Range on Protein: 170-421
Range on HMM: 36-294/296.0
VAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKdRCTVYWPKEM
 ... ||. |||  ..| .|. |||||.|. . .||| || |.     || .|  .|| . ....||||...|.. .||..|.  .  |  .  |||...
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

gkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV----------SGGETRSVHQFHYQSWPD-MGVPQYPTTLISYTQTVKHVHERItANTKGSTPMLVHCS
   . .| |.|.. . ..... . | . ...              ||| |..|... |.    ||   ..||   . |. . |..  . .   |..|..|
..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeegPvvvvss

AGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGN
 |..|.| ....   | .|..| .||.|......|..||..|.. ..|  |   | ||.. . 
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 172-418 5.4e-53 174.6 In-house 34-278 (287) alignment 
Range on Protein: 172-418
Range on HMM: 34-278/287.0
MKPENKAKNRFKNIVAFDHSRVVLETlKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGK
 .  .  |||. ... .|..||.| . . .  ||| ||||.   . ...|||||.| .|...||||........||...|  .| .. .|  |||.   .
eelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.ev

SKTFGGIEVKLRTIEE-FSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHvHERITANTKGSTPMLVHCSAGVGRTGTFISL
    ||  | |   .    ..  | | . .. . |.| |.|... |||| ...     || ..  ||. |  .. ....  |..||...|.||.|.....
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkq.hielardasevGPlvvhddvGiGrsGillat

YCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
. .. .  .  |||.   . ..|. |  .||.. |. |.  |||  | 
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPN9_pd Subfamily PTPN9 448-712 1.7e-50 166.7 In-house 18-292 (297) alignment 
Range on Protein: 448-712
Range on HMM: 18-292/297.0
IEQEFEILNQlTPPVGpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
. .|.. . . .|..|   |.|. |.||. |||. .|| ... |  | .. |   .|||||.|.. . .|. |.||| ||..|. | |||| . .  |||
lskeyaeirn.epveG..tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLNELD-LQDKSCAQYWP--NKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGPKK-GTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSE--------
|   .   .   |.||||  ...| .|| |.|| .. |. ..||..|..|||  |.  . .|  ||...|  .   | | | .|.....| |        
mttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWP.dyGvPssaaslldvlekvrekqalavke

---CVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
     .      |||.||  ||||.| |...  . ... . . ||....||.||. |  .|   .||  ||  . || ..
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 474-708 8.3e-50 164.5 In-house 48-277 (315) alignment 
Range on Protein: 474-708
Range on HMM: 48-277/315.0
ANIDKNRFPNVLPMEKNRPCL-VTKGEaGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKSCAQ-YWPNKdSVQF
 | .|||. |.....| |. | ... .   .||.||.|.. . ||. ..|.| |.. . .| ||.| .     ||||..|  ..|. |. |||.|  | .
enkqknryiniiaydksrvqlpllend.phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviy

GPLKVSIISAEtIRSDYVMRKFEIKGpKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQasGPIVLHCINGIGRSGVFAAIYSAAEKMI
|.. |. .| | . ..| .| . .   ..   .| |...  |  . . |..  |...|.  |     .|   |.||.|| .|.||.| | .. .  ... 
Gkitvtrksee.vnteytvrtlsvvf.gdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqae

TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
..  .|... ....|.||  |.....||   |. . |
aenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 471-712 9e-50 164.3 In-house 24-270 (274) alignment 
Range on Protein: 471-712
Range on HMM: 24-270/274.0
GLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTDYINASFLNTFI-KKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKD
 .. .  |||. ..|| |. | .| . ..|.  ..|||| ..  .  .. ...||| |||.|  | |||.   ...||||| .|  ...  ||.|.|.. 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SV----QFGPLKVSIISAeTIRSDYVMRKFEIKGPKKgTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQAS-GPIVLHCINGIGRSGVFAA
..    ..| ... . .. . | || .||. .|  .. . .|| .    |  ..| | .  ..|.||. |.|  ....|  .|.|.||  |||| |.| |
dyeiserygdveikveki.verndysvrklvlkyler.ersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

IYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
|  |  ..  .. ||... |  || .|  |... .|| . .. ...|.|.
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 445-712 5.2e-49 161.6 In-house 9-279 (287) alignment 
Range on Protein: 445-712
Range on HMM: 9-279/287.0
KLNIEQEFEILNQLTpPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGStDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSP
| ....|.. | . .    .  ||||   |.. |||. .|||....|  |...|| || ||||| .. .. ... |.|.| |.. | .| ||.| . || 
kddvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGs.dyinanyvasytddeafiaaqgPiaatvrdfwravletrsa

VIVML-NELDLQDKSCAQYWPNKD-SVQFGPLKVSIISAETIRSDYVMRKFEIKGPKKG-TLTVKQFQLMGWDGNQKRPASLAPILHLVDA--VSECVRT
.....  |..   . | .|||...  .. |   | ... .    .| .| . .   .   .  |||..|. |  .   |.... |   .|     |  | 
svitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard

SQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
..  ||.|.|.  ||||||.. |..   ...     ||. . | |||  | ... .| |. . || .. | | 
asevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
0051429 (Phosphotyrosine protein) phosphatases II 202-437 8.2e-49 162.0 In-house 2-244 (272) alignment 
Range on Protein: 202-437
Range on HMM: 2-244/272.0
PHSDYYNANYIRDDKG---KKTFIAAQAPNTASINDFWRLiWQENVCSVVMVTNILEGGKDRCTVYWP----------KEMGKSKTFGGIEVKLRTIEEF
| |.|.||...    .   .........| .....||||| ..... ..|....  | |.. |  |||           ..  . ..| . |.|  .| .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

SDHVHRVLDVKQV-SGGETRSVHQFHYQSWPDMGVPQYPttlisYTQTVKHVHEritantkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVD---
.|...|.| .. . | ||.| |...||..|||.|||| .     . . ......        . |.|||||||..||||.. |. .|..| .|  ||   
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.....llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----IFGFIQKMRKDRPNMVQTADQYILIHTALVEAyMSGNTDVPVSSFEAKLSSLQ
     ........|. ||..||| .||. .. ||.|. . . ..|... ..| |  ..
ltnlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_PTPN6_pd Subfamily PTPN6 428-715 1.2e-48 160.6 In-house 8-302 (306) alignment 
Range on Protein: 428-715
Range on HMM: 8-302/306.0
SFEAKLSSLQERNPLTQKLNIEQEFEILNQLTpPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGStDYINASFLNTFI--KKDVFLATQM
. | . | |.. .  ..| ..|.||| |.|          | .  | |  |||. |.||....|  |  .. .|| |||||..... .  ..  ..||| 
eieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgs.dyinanyikkevkgsdksyiatqg

PLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYWPNKD-SVQFGPLKVSIISAeTIRSDYVMRKFEIK--GPKKGTLTVKQFQLMGWDgNQKRPA
 |..|  | |||| .  | ||||. .|..   . ||.|||..  . ..| ..|. .|  .  .||..|.. ..    || . .| |..   |  ..  |.
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWP.dhgvpk

SLAPILHLVDAVSECVRTSQ--ASGPIVLHCINGIGRSGVFAAI---YSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
.   .|.... |..  ....   .|||| || .|||| | |  |    .  ||  .|  .|| ..|| .|. |  ..   .|| . |. ...|...  .
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 447-706 1.4e-48 160.3 In-house 7-262 (283) alignment 
Range on Protein: 447-706
Range on HMM: 7-262/283.0
NIEQEFEILNQLTPPVGPQAFkaAGLPANIDKNRFPNVLPMEKNRPCLVTKGEagstDYINASFLN---TFIKKDVFLATQMPLPHTTGDIWRMVCDWRS
| .  .| |..|. |  .     |    |  |||. ...|....|  | .. .    |||||.|.       ..  ....| || .|  | |.|| | . 
nnklfrevlkrlsvpdldadi..asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

PVIVMLNELDLQ-DKSCAQYWPNKDSVQFGPLKVSIiSAETIRSDYVMRKFEIKGP--KKGTLTVKQFQLMGWdgnqKRPASLAPILHLV--DAVSeCVR
  |||| .|  . .. |.||||.. |...|.. |..   ||    ...... ..     | || .  .|. .|          |.|  ||  . |    .
taivmltklqedlrikCsqyWPkrGsedyGeftvtl.rkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvi.slq

TSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGM
| .  ||||.|| .||||..|| |. .. ... |.| ||.|. || .| .|. .. . ||| . .| .
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0041856 (Phosphotyrosine protein) phosphatases II 176-425 6.4e-47 154.8 In-house 1-179 (182) alignment 
Range on Protein: 176-425
Range on HMM: 1-179/182.0
NKAKNRFKNIVAFDHSRvvletlkddpHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTnileggkdrCTVYWPkemgksktf
|. |||...|. .||||          ..|| |||... .   ..|||.|.|   ...||.|....... ..|..|         .  |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ggievklrtieE-FsdhvhrvldvkqvsggeTRSVHQFHYQSWPDMGVPQyPTTLISYTQTVKHvheritantkGSTPMLVHCSAGVGRTGTFISLYCML
           | .                 .| ..|..| .|||.|||  . .|... ..|..           . | |||||||||||||.. .| |.
...........ell.................erlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmk

AQvieesRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVP
 .     .|...  .. .|. ||.||.| .||.... || | .. ..|...
kl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_PTPN23_pd Subfamily PTPN23 442-713 1.2e-46 153.9 In-house 11-283 (288) alignment 
Range on Protein: 442-713
Range on HMM: 11-283/288.0
LTQKLNIEQEFEILNQLTPPVgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVtkgeAGSTDYINASFLNTFIKK-DVFLATQMPLPHTTGDIWRMVCD
| .| .....|. |.|       . .  |    . .|||. ..|| ..|| .|      .  |||||||..        |.||| ||. | .| |.|| .
ldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

WRSPVIVMLNEL-DLQDKSCAQYWPNK--DSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEC
 .|.||||| .  .|.......|||..  ..|.||.|.|.. | ..  . .| |.....  ... . .|.  ||. |  .   |||   .|...|.| ..
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletldadavksvshlqltsWp.elGvPasPetllqfldevesa

VRTSQ--ASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSS-VDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKF
 .. |  .  |.|.||  |.||.|||| .|.|.... ..   .|| | |.|||..|  |.. ..|.  .|| . |. .. 
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 465-712 6.6e-46 151.7 In-house 31-278 (281) alignment 
Range on Protein: 465-712
Range on HMM: 31-278/281.0
QAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYW
.. .|.  ..|. |||. |.   .. |  .  . |. .||||||.|.... ..  ..||| |.|..  . |.|| . .  .|||. .|..     | .||
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PNKD-SVQFGPLKVSIISAETiRSDYVMRKFEIKGPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQAsGPIVLHCINGIGRSGVFAA
|... ....| ..|. ...|. .. |. |||...  .  | .|.|.. . |  ..  ||. . .|.  ..| .. ....   |.|.||  |.||.|.. |
Pddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWP.dhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyia

IYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
.  ..... .. ...|. . |. || .|  |. .| ||.  |  . ....|
lDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 170-414 7.6e-46 151.3 In-house 27-292 (297) alignment 
Range on Protein: 170-414
Range on HMM: 27-292/297.0
VAMKPENKAKNRFKNIVAFDHSRVVLetLKDDPHSDYYNANYIR--DDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPK
.| ..    |||...|.|.| .|| |  |.  . .|| ||.|.   |.. .  .| || |  |...|||.|.....|  .|||... |.|.|.|. |||.
sakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

EMGKSKTFGGIEVKlrTIEEFSDHVHRV--LDVKQVSGGETRSVHQFHYQSWPDMGVP-------QY-----------P--TTLIS-YTQTVKHVHERIT
  .. .. | . |.   . ..||. .||   ... .   |.| |.   . |||| |||       ..           |   .|.  .|  |    | . 
vvqerlkagdvvve..flsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr

ANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
|.   ....||||||||||.|  .    .||..  .   |.  .....|. |. .||| .|. |...| .
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_PTPN3_pd Subfamily PTPN3 466-710 4.3e-45 148.8 In-house 32-276 (280) alignment 
Range on Protein: 466-710
Range on HMM: 32-276/280.0
AFKAAGLPANIDKNRFPNVLPMEKNRPCLVtkgeAGSTDYINASFLNTFIKK----DVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQ-DKSCA
| .|| .|.|..|||. ..|| .. |  |.    ...||||||...|  |        ..||| ||..|. | |.|| . .| .|||| .|  .  . | 
aisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPN-KDSVQFGPLKVSIISAeTIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrtSQASGPIVLHCINGIGRSG
||||. .|....| ..| . .    .. ||.|.. .|  . |   .. |.| . |  ... | . | .|..|. | ..   | .. |.|.||  ||||.|
qyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWp.dhgvPddsadflefvervrklr..sgkeePvvvhCsaGigrtG

VFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEG-MAEYM
|. ..  |  .. .  .| . . |...|  | .......||    |  .. |.
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 168-418 6.9e-45 148.4 In-house 33-278 (307) alignment 
Range on Protein: 168-418
Range on HMM: 33-278/307.0
KTVAMKPENKAKNRFKNIVAFDHSRVVLETlkDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPK
 ||     |  |||.... . |..|.|...  |   |||  |||.      | ||.|| |  ... .|| .. ||.| ||.|. ...| .| .|  ||| 
vtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl

EMGKSKTFGG----IEVKLRTIEEFS--DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKhvheritantKGSTPMLVHCSAGV
| |. ..||     | |.   .....  ...  | ..| . ....|..... .. ||| ||||   | |   ..|.              |..|||||||
eegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..........ydtnpvvvhcsaGv

GRTGTFISLYCMLAQVIE-ESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
||.|| ...  .  ..|. .   |.  .....|..|.  .||  ||. .|  |.| ..
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 173-415 9.2e-45 147.5 In-house 53-281 (290) alignment 
Range on Protein: 173-415
Range on HMM: 53-281/290.0
KPENKAKNRFKNIVAFDHSRVVLetlKDDPHSDYYNANYIRDDkgKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKS
|  .  |||.|..|  | .||.|   ||  . ||  |||..    | .|| .| . .... |.||.. ||.|  .||. ...| || .|  |.|.. |. 
kntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

KTFGGIEVKLRTIEEFSDH-VHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKhvheritantKGSTPMLVHCSAGVGRTGTFISLY
 ||| | |     ..  .. ....| |...  |    .. .. .||||  |..   .|.   ....          | | |. ||||||.||||||... 
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..........kasGpvvvhcsaGiGrtGtfvaie

CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
  |  ...   .|. . .. .|. | | ||   ||...  .|..
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN13_pd Subfamily PTPN13 447-711 1.1e-44 147.7 In-house 12-270 (273) alignment 
Range on Protein: 447-711
Range on HMM: 12-270/273.0
NIEQEFEILNQLTPPVGPQAFKAAglpANIDKNRFPNVLPMEKNRPCLVTKGEagstdYINASFLNTFIKKDVF--LATQMPLPHTTGDIWRMVCDWRSP
. ..||. |..| |    .  | .   .| ||||. ||||... |  |  .|      |||||...  . || .  .|.| |||.|. |.|.|| . .. 
qPaeefkelrelkpldtcevgkkk...enkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

VIVMLN-ELDLQDKSCAQYWPNKDS--VQF-GPLKVSIISAETiRSDYVMRKFEIKGPKKGT-LTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEcvrT
||.|.  | . .   | .|||.. .  ..  . |.|. .  .  ....|.|....|  . |    | ..... |  . . |.| |..|..|  | .    
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqk.ldgfvvralavkdsesgesrevahlnfvkwP.dhgvPssaaellqfvaevrr...l

SQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
 . .|||| ||  ||||||.. .|. . . .  | ..|. . |..||  | ... . |||  .|. . | .|
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRN_pd Subfamily PTPRN 441-710 2.1e-43 143.1 In-house 24-292 (297) alignment 
Range on Protein: 441-710
Range on HMM: 24-292/297.0
PLTQKLNIEQEFEILNQLTppVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLN-TFIKKDVFLATQMPLPHTTGDIWRMVC
 |..| ..|.|.| | .      |.. ..|  . |..|||  .||| ...|  | .. .| ..||||||..  .  .. ...||| ||..|  |.|.|| 
hlknkdrlekewealcaye..aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvw

DWRSPVIVMLNELDL-QDKSCAQYWPNKDSVQFGPLKVSIISAETIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECV
.  . |||.| .|.  . | |..|||.. |  ..  .| ..|      ||..| | .|  . . | || ||  . |  ..  |||  ..|..   |  . 
eqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp.eegvPasaksllefrrkvnksy

RTsqASGPIVLHCINGIGRSGVFAAIYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
|    | |||.|| .| ||.||. .|    ....     .||  ... || .|| .... ||. ...  .|| .
rG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 165-415 8.7e-43 141.2 In-house 24-257 (267) alignment 
Range on Protein: 165-415
Range on HMM: 24-257/267.0
GIAKTVAMKpeNKAKNRFKNIVAFDHSRVVLETLKDDphsdYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNIlegGKDRCTVY
 |.. .|.|  |...||. . . .|..||.| | ...    | || |.   | |..||. | |   .| ||. .| ...|  .|..|..   ..|    .
tisqsiaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlf

WPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSgGETRSVHQFHYQSWpDMGVPQYPttlisYTQTVKHVHERITaNTKGSTPMLVHCSAGVGRT
|| .||..| .  . |.    .|  |.   .|..|      .. |  ..|. | .. . . |     | . .  .  .     .|. |..|.||.||||.
wPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkw.nintnnkp.....ylkplfgilaknq.lengnrPlvvacsdGvGrs

GTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
|||. .. .| .. .|. .||| |..|.|. |. .|.| ..|| ||  |.|
Gtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0036282 (Phosphotyrosine protein) phosphatases II 204-410 1.2e-42 140.9 In-house 2-163 (174) alignment 
Range on Protein: 204-410
Range on HMM: 2-163/174.0
SDYYNANYIRDDKGKKTFIAAQAPNTasindFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemgksktfggievklrtieefsdhvhrvldvkqVSG
|||.||...      . .|| |.| .     ||........ .|||...  | |. .|  |||                                   . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

GETRSVHQFHYQSWPDMGVPQYPTtLISYTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIeESRVDIFGFIQKMRKDRPNMVQTA
 ..|...|..|  |||.|||  .. |..  . |......     ... |.|||||||||||||.. .| || . . || ||.. .....|. ||.|||| 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

DQYILIH
.||. ..
sQyrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 150-415 1e-40 134.2 In-house 10-267 (281) alignment 
Range on Protein: 150-415
Range on HMM: 10-267/281.0
QDGFAHEFGLLPSDDGIA-KTVAMKPENKAKNRFKNIVAFDHSRVVLET-LKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSV
 | | .||  || |      ||  .| |. |||. || ..| ||| |.  . .   .||  |||||    |. .| .| |.  .  ||||.|||||  ..
lddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKqvSGGETRSVHQFHYQSWPDMGVPQYPTTLIsytqtvkHVHERITANt
||. ..||  ...|. |.|..      |  . |.          |   |..     |||| . .. .. |||  ||.    ..       ..  .| |  
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevml.......kilrkirar.

kgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEE-SRVDIFGFIQKMRK-DRPNMVQTADQYILIHTALVE
  ||| ..||||||||.||....   |  .    .  ||   . ..|   |   ||| .||.||   |..
..stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 139-415 3.8e-40 132.5 In-house 10-285 (305) alignment 
Range on Protein: 139-415
Range on HMM: 10-285/305.0
VEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKP-ENKAKNRFKNIVAFDHSRVVLETlkDDPHsDYYNANYIRDDKGKKTFIAAQAPNTASINDFWR
.. |..   .   |.  ||  .   . . |  |.|  ... |||.|..  .|. || ||.    || .|  |||.      | || .|||   .  ||| 
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkleg..pwph.eyihanyvstptnpkrfictqaplektcadfwy

LIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGG----IEVKLRTIEE--FSDH----VHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPT
. .|..| .. |. |.|| |  .|. |.. . ..  .|      | ||. . ..  | ..    | .   | . .|...| | ..|.  ||| |||   .
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl

TLISYTQTVKhvheritaNTKGstPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIF-GFIQKMRKDRPNMVQTADQYILIHTALVE
...   .  .         .||  |. ||||||.||||. . |  .| |...   ..     .||.|..| | .|| .||...|  ...
ailellekar........pskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 474-718 9.8e-40 131.1 In-house 39-301 (301) alignment 
Range on Protein: 474-718
Range on HMM: 39-301/301.0
ANIDKNRFPNVLPMEKNRPCLVTKGE--AGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQ-DKSCAQYWPN--KDS
.|   ||| |. ....||  | .| .    ...|||||... . .|  | |.| |. .|  |.||.. . .   |||. .|. .  ..| |||||  ..|
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes

VQFGPLKVSIISAE-----TIR-----------SDYVMRKFEIKGPKkGTLTVKQFQLMGW--DGNQKRPASlapILHLVDAVSECvRTSQASGPIVLHC
 .|||..| ...       .||             |..|||..|  |  . .| |.|.  |  ||  . |.    .|. .| |    . .   ||.| ||
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprt...vLqviddvihr.qqkigggpvvVHC

INGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
 ....||||. ..  . |    .  ||.|| .|..| ..| ..   .||.  |. . .|..  . |||
SdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
0043147 (Phosphotyrosine protein) phosphatases II 201-410 5.3e-39 129.0 In-house 2-154 (172) alignment 
Range on Protein: 201-410
Range on HMM: 2-154/172.0
DPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNIleggkdrctvywpkemgksktfggievklrtieefsdhvhrvldvKQ
|..|||.||.|.      . ||| |.|    ..||||.......  .|..|.                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

VSGGETRSVHQFHYQSWPDMGVPqYPTTLISYTQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLaqvieeSRVDIFGFIQKMRKDRPNMV
   ...|.. |..| .|||.|||  .  |..  . .....     . . . |.|||||||||||||.. .| ||       .....  .. .|. ||..|
dpellerlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav

QTADQYILIH
|. .||....
qnpsqyrfly
subfamily_ptpA1_pd Subfamily ptpA1 154-375 9e-39 128.4 In-house 24-254 (418) alignment 
Range on Protein: 154-375
Range on HMM: 24-254/418.0
AHEFGLLPSDDGIAKTV-AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIrDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTN
  || ||    | ..|    |  | .|||. ||.  .|.|| |. ..|   ||| ||||| |    | ||..| |   .| ||||..|.. .  .||.. 
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsr

ILEGGKDRCTVYWPKEMGKS---------KTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERI
  |  . .|  |||...|           . ||   |.|  . .  ..     ...    |||| . |..|. |||  .|..   .    ...   ...|
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

TANTKGSTPMLVHCSAGVGRTGTFISLYCMLA
  ..    |..||||||||||||| .   |. 
ipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 477-712 1.1e-38 127.8 In-house 22-266 (270) alignment 
Range on Protein: 477-712
Range on HMM: 22-266/270.0
DKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFI-KKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSV----Q
  ||. ..||  . | .| .  |   | |||| ... |  .|  ..|.. ||| |. . |||. . ... |||. .|  . .  |..|||..       .
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

FGPLKVSIISaETIRSDYVMRKFEIKgPKKGTLTVKQFQLMGWD--GNQKRPA---SLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYS
.| .||  .| |. .. |.... ...  |  .  .  |.   |   |  ...    |   .|... || .  .  . ..|.. || .|.||.|.. |.  
dgkikvlals.eekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

AAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
| . . ....||. . ...|| .|. ... ..||   |....||...
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN14_pd Subfamily PTPN14 440-712 1.8e-38 127.3 In-house 14-298 (300) alignment 
Range on Protein: 440-712
Range on HMM: 14-298/300.0
NPLTQKLNIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAgSTDYINASFLNTFI--KKDVFLATQMPLPHTTGDIWRM
. | .||.  . |   .....      ...| || | .||||..||| |.||  |..  |. ||.||||| ... .  |.  ....| ||..|  | |.|
kilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqm

VCDWRSPVIVMLNELDL-QDKSCAQYWPNK----DSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVD
| .    .|||| |      . . .|.|..    ..|.||  ||.    |.  . .. .....|  | |   ||  .| . |  ... |  . . |. ..
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsed.sdsvittglklkhlpskeertvwhlqytDWp.dhgvPeDvkgflsyLe

AVSE-CVRTSQAS------GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
 |   . .|.. .       |...|| .|.||.||        . . .. ..|| ....|||  | ...... ||   |. . .|.|.
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 445-711 1.8e-38 127.1 In-house 5-260 (267) alignment 
Range on Protein: 445-711
Range on HMM: 5-260/267.0
KLNIEQEFEILNQLTPPVGPQAFKAAglPANIDKNRFPNVLPMEKNRPCLVTKGEAgstdYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSP
. .||.||| ......     .   |    | ..||. ..|| ...|  | || |     |||||..... .|  |..|| ||  | .| . .. | . |
eceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

VIVMLNELDLQdkSCAQYWPNK--DSVQFGPLKVSiISAETIRSDYVMRKFEIKGPKKGTLTVKQFQLMGWDGNQKRPASLAPILHLVDAvsecVRTSQA
|||.|     .     ..|| |  .. ..  | |   | |    || .  .|.|  .. .  |  .    |. | .    | |.. ..       .  ..
vivlltkvftd..nirlfwPPkmgqakkyqdltve.hslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilak....nqleng

SGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
. |.|..| .|.|||| |  |.|  |.. |.. .|||. ....|  |...... ..|  ..| .||| .
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 175-415 2.4e-38 126.8 In-house 42-269 (288) alignment 
Range on Protein: 175-415
Range on HMM: 42-269/288.0
ENKAKNRFKNIVAFDHSRVVLEtlkDDPHSdYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
.| ...|..|.   | .|| |.   |||.  | .|| .   | |. .| ||||  . |. .|... ...|  .||....|| ||..  .|.| ..|..  
anptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRS-VHQFHYQSWPDMGVPQyptTLISYTqtvkHVHERItanTKGSTPMLVHCSAGVGRTGTFISLYCM
.| .    .   .  |.. .|  ..    ||..  | . |.. |.| |||.     .|.     .. |..    .   |..||.|||||||||.|    .
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPe...nylspl....rllevl...kslqkPivvhssaGvGrtgtlililia

LAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
| ..  .  . |  ...|.|..| . .||  ||. .|  . |
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
0041856 (Phosphotyrosine protein) phosphatases II 475-711 2.5e-38 126.8 In-house 1-172 (182) alignment 
Range on Protein: 475-711
Range on HMM: 1-172/182.0
NIDKNRFPNVLPMEKNRpclvtkgeagSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNeldlqdksCAQYWPnkdsvqfgpl
|.||||....||.. .|            |||||...    . . |.||| ||..|. | .||. ...  .||.|.        . .|||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

kvsiisaetirsdyvmrkfeikgpKKGTLTVKQFQLMGWDGNQKRPasLAPILHLVDAVSEcvrtsqASGPIVLHCINGIGRSGVFAAIYsaaekMITDS
                        .. . .. |.. ..|...   .  |  .|.....| |       .||.. ||  |.||.|...|.|     ..   
........................ellerlgiqylylpwpDhgvpd..ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay.....lmkkl

SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.|.... || .|  || |... .|| ...  . |...
gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_PTPN1_pd Subfamily PTPN1 468-715 2.1e-37 123.4 In-house 25-276 (290) alignment 
Range on Protein: 468-715
Range on HMM: 25-276/290.0
KAAGLPANIDKNRFPNVLPMEKNRPCLvtkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK
..| ||.| ..||. .| | .. |  |    | ...||||||...    |  .. || |||.|..  |.|| . .|  .||||.. . .   ||||||..
reaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

DS---VQFG--PLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVF
..   ...    ||| .|| |. .| |..|..|..    . | .. .|  . |  .   | | |  |...  | |.   |.  || |.||  |||||| |
eeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwp.dfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

AAIYSA---AEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
. . .     ||    ||||| . .  ||  |  .|   ||    |  . | .|.  .
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
0049772 (Phosphotyrosine protein) phosphatases II 170-415 7.6e-37 123.1 In-house 40-278 (314) alignment 
Range on Protein: 170-415
Range on HMM: 40-278/314.0
VAMKPENKAKNRFKNIVAFDhSRVVLETLKDDPhSDYYNANYIRDDkgkKTFIAAQAPNTASINDF----------WRLI--WQENVCSVVM--------
|| ...|. |||...|. .| .||.| .|  .  |||.||.|..     ..|||.|.|.   ..||          ||..  .. ||  .||        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------VTNILEGGkdrcTVYWPKEMGKSKtfggievklrtiEEFSDHVHRvldvkqvsggeTRSVHQFHYQSWPDMGVPqyptTLISYTQTV
              ... ..|      ......   |            ||  |. .            .| . ....  .|| ..|    .|  . . .
elsrLdaAlgKtpllildgng....neptaadlellk............eelydpelf...........erlgikylripvpDgsap....lledfdefl

KHVHERitantKGSTPMLVHCSAGVGRTGTF-ISLYCMLAQvieesRVDIFGFIQKMRKDRP-----NMVQTADQYILIHTALVE
....|      .  .| ||||.||.|||||| .  |.|...     .|..   .. .|. ||     ..... .||. |. || |
efieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealle
0046846 (Phosphotyrosine protein) phosphatases II 197-413 1.7e-36 121.0 In-house 5-169 (176) alignment 
Range on Protein: 197-413
Range on HMM: 5-169/176.0
TLKDDPHSDYYNANYIRDDKgkktFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKtfggievklrtieefsdhvhrvl
 | .|...|| |||.|  ..    .|| |.|   .. ||.........  ||..|.  | |. .|. ||| ... .                        
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

dvkqvsggetrsvhQFHYQSWPDMGVPQYpttlISYTQTVKHVHERITANtkgsTPMLVHCSAGVGRTGTFISLYCMLAqvieESRVDIFGFIQKMRKDR
              |...  |||.|||..        . .. ..|.....     | |||||||.|||||.. .| .      |  ....  ....|. |
..............qylhlpwpDhgvpdl....elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqR

P-NMVQTADQYILIHTAL
| ..||| .||  .. ..
plgavqtpeQyrflyefe
0044763 (Phosphotyrosine protein) phosphatases II 188-414 4.2e-36 119.6 In-house 2-168 (178) alignment 
Range on Protein: 188-414
Range on HMM: 2-168/178.0
FDHSRVVLETLKDDPHSDYYNANYIRDDkgkktFIAAQAPNtasiNDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGksktfggievklrtiee
.|..||.|..| . . |||.||..| ..     ......|.     |...|...... ..|..|. ||.|.  |  |||.|.|                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

fsdhvhrvldvkqvsggetrsvHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSAGVGRTGTFISLYCMLAQvieesRVDIFG
                       |...  .||.|||. .  .   .. .....       .   | ||||||||||.||.. .| |. .     ..... 
......................iqylhipipDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glslee

FIQKMRKDRPnMVQTADQYILIHTALV
 |. .|. || .|.. .|.  ..    
aielvrerRp.ivpnpgqlrqLyefel
0049260 (Phosphotyrosine protein) phosphatases II 218-410 6.2e-36 118.7 In-house 8-143 (152) alignment 
Range on Protein: 218-410
Range on HMM: 8-143/152.0
KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWpkemgksktfggievklrtieefsdhvhrvldvkqvsggetrsvhQFHYQSW
.. |||.|.|   ...||||.... ..  .||.|. || ||. |  |.                                             |...  |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

PDMGVPQYPTTLISYTQTVKHVheritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLaqvieeSRVDIFGFIQKMRKDRPNMVQTADQYILIH
||.|||. .  |.   . ...       . . . | |||||||||||||.. .| ||       .|... ... .|. ||..|.. .|.....
pDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0049772 (Phosphotyrosine protein) phosphatases II 465-714 7.1e-36 119.9 In-house 36-284 (314) alignment 
Range on Protein: 465-714
Range on HMM: 36-284/314.0
QAFKAAGLPANIDKNRFPNVLPMEkNRPCLvTKGEAGSTDYINASFLNTFikkDVFLATQMPLPHTTGDI----------WRMV--CDWRSPVIVM----
. ...| |..|.||||....||.. || .|  . .  ..||||||....|     |.||| ||..|  |.          ||||   |... .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LNELDLQDkscaqywPNKDSVQFGPLKvsiisaetirsdyvmrkFEIKGPKKGTLTVKQFQLMGWDGnQKRPaSLAPILHLVD
                 |..|| .        .  .   .  ||                  |.  |.. . .. ..  . ...    | .|. ......
vladelsrLdaAlgKtpllildgng.......neptaadlellk.................eelydpelferlgikylripvpD.gsap.lledfdefle

AVSECvrtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMitdsSVDIFQSVKRLRANRP-----SMIESVDQYSICYEGMAEYMKKFD
.. |.    .. ||.. ||  |.||.|.|....    ..     |.. . ....|. ||     ..||. .||  ..| . ||.|.. 
fieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
PTPc_DSPc_SM00012 309-414 2e-35 116.5 In-house 2-104 (105) alignment 
Range on Protein: 309-414
Range on HMM: 2-104/105.0
VHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITAntkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEE-SRVDIFGFIQKMRKDRPNMVQTADQYI
|...|| .|||.|||.... .... . ||.... ..     |.|..|||||||||||||. |...| |. .| ..|||| .....|| ||.|||| .||.
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl

LIHTALV
 ...|| 
flyrall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 176-418 2.2e-35 116.8 In-house 55-290 (305) alignment 
Range on Protein: 176-418
Range on HMM: 55-290/305.0
NKAKNRFKNIVAFDHSRVVLEtlkDDPHSDYYNANYIRDD-KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
...|||.... . |.| | |.   . . |||  |||.      .| ||.|| |   .|..|| .. |..|  .||. . .| || .|. |||  .|. ..
aitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

F-GGIEVKL----RTIEEFSDHVHRVLDVkQVSGGETRSVHQFHYQSWPDMGVPqyPTTLISYtqtvkhvhERITANTKGSTPMLVHCSAGVGRTGTFIS
. .|| |.     . .|  ..    .|..   ||... || ....  ||| |||  |  | |         | ..|      |..||||||.||||| ..
lksgivvenvsgskpmerdaeiqitllnl.tysgdqkmsvrhlqwtewpdrgvp..pckltsl........ellsairgskvpivvhcsagigrtgtiva

LYCMLAQVIEESRVD-IFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
.  .| .. |. ..  .  ... .| .|   .|.  ||. ||  ... ..
ieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 513-705 2.2e-35 116.8 In-house 231-433 (440) alignment 
Range on Protein: 513-705
Range on HMM: 231-433/440.0
TFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELdlQDKSCAQYWP-NKDSVQFGPLKVSIISAETIRSdYVMRKFEIKGpKKGTLTVKQFQLM
 . ||. |.||||||  |  |.||.| |.|   |.|||.|  .||.|. ||| |  || |||. |    .| .     .| .|.|  |.    ..||.. 
gyskknafiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelky.keevheirqfevq

GW------DGNQKRPASLAPILHLVDAVSECV--RTSQAS-----GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQ
 |      || | .   .  .| |.| .  |   |... |      ||..||. ||  |||| ..    |..  | ..|.|| .. ||  || .. .. .
twptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltd

YSICYEG
| .||  
yllcykl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 175-419 3.1e-35 116.5 In-house 34-272 (285) alignment 
Range on Protein: 175-419
Range on HMM: 34-272/285.0
ENKAKNRFKNIVAFDHSRVVLETlkddPHSDYYNANYIRD-DKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSK
 |   ||. .. . . .||||.        ||  |...|   | . |.|..| |   ...|||..|.||... |.|.  ..||| ..|..|.|...|.  
anpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

TFGGIEVKLRTIEE--FSDHVHRVLDVKQVSGGETRSVHQFHYQ--SWPDMGVPQYPTTLISYTQTVKHVheritaNTKgSTPMLVHCSAGVGRTGTFIS
 ||  |. |   .|   .  .   | | .     .  ..  | |   |||   |.    .|   . ||.|      | |  .|. |||||||||| ||. 
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv......npk.ekpicvhcsagvgrtatfvg

LYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
.     ...|.  ....  ...||  | . ||.  |.....  |.| .. 
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 448-711 5.7e-35 115.6 In-house 22-280 (439) alignment 
Range on Protein: 448-711
Range on HMM: 22-280/439.0
IEQEFEILNQLTPPVGPQAFKAAGlPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
....|| .|   |.   .|  ||    .  |||. .| ...  |  |        . |||| ... . ......|||.|  .|| | ||.| . ..  ||
fkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtiv

MLNELDLQDKscaqYWPNKDSVQFGPLKVSIISaETIRSDYVMRKFEIKGP---KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEcVRTSQASG
|| .|    |    ||| .. | .| . | .   .    .||.| | .       .   || ||. . |  ... ||  . .|... |.      ..  |
mltnlvesyk....ywpsdaevcygdiavrvdr.nielpnyvirgfkvfnerdttekertvlqfhyiawp.dknvpaqashvldflrains.andkeeyg

PIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|.|.||  |.||.|   |.  | |.. ..  |||   || || .|  |.... || . |. . | ..
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 152-425 1.1e-34 114.4 In-house 28-297 (310) alignment 
Range on Protein: 152-425
Range on HMM: 28-297/310.0
GFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETlKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVT
|.....  | ...  . |     ..  |||. ..|  | ||| |.      . ||  |||.. .  ..||| .| |   .| ||||.|.||   |.... 
glvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

NILEGGKDRCTVYWPKeMGKSKTFGGIEVKL--RTIEEFSD---HVHRVLDV----KQVSGGETRSVHQFHYQSWPDMGVPQypttlisytQTVKHVHER
.. | |. .|  |||  .| ..|.| | |     . |||      |  | |     .| .  .   |   ..  |||.|||.         . .. | .|
kvgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtvpqr

ITANTKgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVeAYMSGNTDVP
. |. .   | .||||||..|... ..|   . .. .  .||.   . ...|.|   .||  ||..|.   . ..  |.|.| 
llaqvr.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 475-704 2.3e-34 113.7 In-house 3-233 (237) alignment 
Range on Protein: 475-704
Range on HMM: 3-233/237.0
NIDKNRFPNVLPMEKNRpcLVTKGEAGSTDYINASFLNTFIK-KDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDS-VQF
|  |||. |.  ....|  .| ||  ...|||||..|. |      ..|.| ||  .  |.|.|| . .  |||||  | . ... | .|||. |    .
nkiknrygnivaydhsr..vvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPLKVSIISAETIrSDYVMRKFEI--KGPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEK
| | ||.   | . ||| .| . .  .. .|.   ..|.|.  |  ..  |   | .| .   . .  .  . ||| ..||  |.||.|.|  | .   .
gvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswp.drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

MITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
      |||.. |. .  .|| .|.. ||| . ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihq
0051082 (Phosphotyrosine protein) phosphatases II 202-413 4.3e-34 112.6 In-house 1-149 (151) alignment 
Range on Protein: 202-413
Range on HMM: 1-149/151.0
PHSDYYNANYIRDDkgkktFIAAQAPnTAsinDFWRLIWQENVCSVVMVTNILEGGkdRCTVYWPKEMgksktfggievklrtieefsdhvhrvldvkqv
|.|||.|..|. .      ... ..| .|   ||..|...... ..|....  | |   |. |.|..                                 
plsdyinfsyvtgg.....lyrsggp.la...dflellkelgiktivnlrseeerg..ycpeylpelg................................

sggetRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHvheritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQvieesrVDIFGFIQKMRKDRPNMVQ
     . |..... .||| |.|... ..... . . .         |.. |.|||||||.|||||.. ||.|| .      |...  .. .|. ||..||
.....ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq

TADQYILIHTAL
. .|..... ||
pnqqflfqlfal
0036282 (Phosphotyrosine protein) phosphatases II 503-704 2.9e-33 110.4 In-house 2-164 (174) alignment 
Range on Protein: 503-704
Range on HMM: 2-164/174.0
TDYINASFLNTFIKKDVFLATQMPLPhttgdIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNkdsvqfgplkvsiisaetirsdyvmrkfeikGPKKG
.||||||.|. ..  . ..|.| ||.      |.|...... ..|||.|.   .   | .|||                                 ..  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TLTVKQFQLMGWDGNQKRPASLapILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAAEKMItDSSVDIFQSVKRLRANRPSMIESVDQYSI
. .. |.. ..|....  . |   .|..|..| |..     .||.. ||  |.||.|...|.|     ..  | ||... |..||  || |... .||  
erlgiqylylpwpDhgvpdlsi..llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYE
.|.
lyy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 300-453 4.9e-33 109.1 In-house 82-230 (440) alignment 
Range on Protein: 300-453
Range on HMM: 82-230/440.0
QVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNM
 ..| |.|...|.|||.||| |||..   ..   | |.. .|.      |. |.|||||||.||||  |.. ..| ..    ..||| ||. ||..||.|
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.....agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqm

VQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQERNPLTQKLNIEQEFE
||| .|| ..| |..|. ..|.| .       ..  .|  || |.|  ..||||
vqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
0051429 (Phosphotyrosine protein) phosphatases II 503-713 5.1e-33 110.3 In-house 4-228 (272) alignment 
Range on Protein: 503-713
Range on HMM: 4-228/272.0
TDYINASFLNTF---IKKDVFLATQMPLPHTTGDIWRMvCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSVQFGPLKVSIISA-----------ETIRSD
..||||......   .|.........|||.|  |.||. ....  .||.| ... ..   | .|||. . ...  |  |  .            |.. .|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVMRKFEIK---GPKKGtLTVKQFQLMGWDGNQKRPASLAPILHLVDAvsecvrtsqaSGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVD-------
|..|.....   ..... ..| ... ..|      . .|  .|.|. .          .||.. ||  |..|.|...|..  .. .  .  ||       
yilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld..........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKF
 ... |..||| || .... .||  .|| ..|.....
yleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_CG42327_pd Subfamily CG42327 153-337 3.9e-31 102.9 In-house 7-191 (319) alignment 
Range on Protein: 153-337
Range on HMM: 7-191/319.0
FAHEFGLLPsdDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRD-DKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVT
 | ||  ||    ||.. .. .  | |.|. |.| . ..||||.   ||... | .|.|.|  |. .  .||||..   |  ||||..|. .   .| .|
vaeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

NILEGGKDRCTVYWPKEMGK--SKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYqSWPDMGVPQYPTTLISYTQTVK
.. | | ..|. |.| . .    ...| | | |.  |    ..   | .|.| . |.| .  . |  |.. .||  ...||.    |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 164-407 4.4e-31 102.8 In-house 40-271 (301) alignment 
Range on Protein: 164-407
Range on HMM: 40-271/301.0
DGIAKTVAMKPENkaKNRFKNIvAFDHsRVVLETLKDDPHSdYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTV
| | .. |  |..  |.|....   .     .| ..|        ||.|  .   . |||.|.| ... .||| .. | .|  .||... .|  ...|. 
dhitesyaylpkd..khryptv.PckP.stavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekcee

YWPKEMGKSKTFGGIEVKLRTIEEFS-D-HVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKhvheritantKGSTPMLVHCSAG
| | .....   |  ..|... |    .  ..| |.|.  .|  .||.|  . |..|.| |||.  . |    . ||          |   |..||||||
ylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk..........ksekPivvhcsaG

VGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYI
.||. .||.  ..  .|  . ....   ....|..| | |||  |  
iGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 474-702 5.7e-31 102.5 In-house 7-233 (239) alignment 
Range on Protein: 474-702
Range on HMM: 7-233/239.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIK-KDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSvQF
 |  |||. |..  ...|  |    .   .||||||.|  .      ..|||  .  ..||.|||. . |  |||||  | . . | | ||||.  | ..
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

GPLKVSIISAETIrSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAEKM
  |.|..  .| . .||..| | .    .     | |...  |  ..  |   . .| |   ...   .   . | |.||  |.||.| |  | .   . 
cnlrvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqa

ITDSSVDIFQSVKRLRANRPSMIESVDQYSIC
  . .||||. || .| .|| |... .|| . 
kkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_egg_pd Subfamily egg 164-414 6.5e-31 102.1 In-house 28-267 (307) alignment 
Range on Protein: 164-414
Range on HMM: 28-267/307.0
DGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGgkDRCTV
| |. | |.. .|. | | | .   | ||| ||  .     |.  ||... .    .|| ||||   . .||||...||.|  .||.|   |   .||  
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPKEMGKSKTF--GGIEVKLRTIEEFSDHVHRVLDVKQvSGGETRSVHQFHYQSwpDMgvpQYPTTLISYTQTVKHVHeritantKGSTPMLVHCSAGV
||||   .|  .  |.....   ... .| . ||  .|   ||.    .  |.|   |.   .. . . |  . ....        . |.|..|..  ||
ywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg..dv...nnssdvysplrvlrklr.......nlskpvvvqdilGv

GRTGTFISLYCMLAQVIEE--SRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
 ...|....   | ...     .  .   .. .|. |.  |... .|....  ..
skaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 474-702 6.9e-31 102.2 In-house 6-232 (239) alignment 
Range on Protein: 474-702
Range on HMM: 6-232/239.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIK-KDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSvQF
 |  |||. |..  ...|  |    .   .||||||.|  .      ..|||  .  ..||.|||. . |  |||||  | . . | | ||||.  | ..
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

GPLKVSIISAETIrSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAEKM
  |.|..  .| . .||..| | .    .     | |...  |  ..  |   . .| |   ...   .   . | |.||  |.||.| |  | .   . 
cnlrvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqa

ITDSSVDIFQSVKRLRANRPSMIESVDQYSIC
  . .||||. || .| .|| |... .|| . 
kkqktvdifnyvkairedrphmvqtseqyvfi
0043147 (Phosphotyrosine protein) phosphatases II 502-703 1e-30 102.1 In-house 4-154 (172) alignment 
Range on Protein: 502-703
Range on HMM: 4-154/172.0
STDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELdlqdkscaqywpnkdsvqfgplkvsiisaetirsdyvmrkfeIKGPKKG
..||||||.|.. .. | |.||| ||..|. | |||. ..   .||.|.||                                           . |.. 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

TLTVKQFQLMGWDGNQKRpaSLAPILHLVDAVSECVrTSQASGPIVLHCINGIGRSGVFAAIYSAAekmitdSSVDIFQSVKRLRANRPSMIESVDQYSI
. .. |.. ..|. .     .|. .|.... . | .   . .||.. ||  |.||.|...|.|          ...... |. .|. || .... .||  
erlgiqylylpwpDhgvp..llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

CY
.|
ly
0046846 (Phosphotyrosine protein) phosphatases II 498-711 1.9e-30 101.3 In-house 7-174 (176) alignment 
Range on Protein: 498-711
Range on HMM: 7-174/176.0
GEAGSTDYINASFLNTFikkdVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSVQFgplkvsiisaetirsdyvmrkfeik
|. .. |||||... .      ..||| |||.|. | ..|. ...  ..|.|.|. .|.  .|..|||   ....                         
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

gpkkgtltvkQFQLMGWDGNQKRPAslAPILHLVDAVSECVRTSqasGPIVLHCINGIGRSGVFAAIYsaaeKMITDSSVDIFQSVKRLRANRP-SMIES
          |.. ..|. ..  .   . .|.|.... |...     ||.. ||  ||||.|...|.|     ....  ..... ....|. ||  ....
..........qylhlpwpDhgvpdl..elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

VDQYSICYEGMAEYMK
 .||  .|| . ...|
peQyrflyefellllk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 451-713 5.9e-29 95.6 In-house 30-286 (290) alignment 
Range on Protein: 451-713
Range on HMM: 30-286/290.0
EFEILNQLTPPVGPQAFKAAGLPANI--DKNRFPNVLPMEKNRPCLvTKGeaGSTDYINASFLNTFikKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVM
  | |..| | .  | ..   . .|    |||. .|   .| |  |   |  .  ||. | ...    | .|. || .|  |. |||||| . .  .|||
akeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvil.kdG..ydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivm

LNELDLQDK-SCAQYWPNKD--SVQFGPLKVSIISAETIRSDYVMRKFEIKGPKKGT-LTVKQFQLMGWDGNQkRPASLAPILHLVDAvsecVRTsqASG
| ||  . |  |.||.|.|.   . || . |     ..  .. ... . ..  ..|    .| .... |  .   . |   .| .. .    .|.  |||
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valstlallrtlri....lrk..asG

PIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKF
|.|.||  ||||.| |.||  ... ..   ..|. . |. ||  | . ..   || .  | . .. |.|
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 448-710 4.2e-27 89.9 In-house 18-277 (307) alignment 
Range on Protein: 448-710
Range on HMM: 18-277/307.0
IEQEFEILNQLTPP-VGPQAFKaaglpANIDKNRFPNVLPMEKNRPCLVTKGEagSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
. .||..| . ||  |  .||.     || ||||. .|  ..|.|  . ..|   ..||| | .| . ||   |...| ||  |  ..| |. . .   .
lvdefrvlakktpegvtveafs.....antdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VML-NELDLQDKSCAQYWPNKDSV--QFGP----LKVSIISAETIRSDYVM---RKFEIKGpKKGTLTVKQFQLMGWDGNQKRPASLAPIlHLVDAVsec
.|| . ..|    | |||| ..     ||     . |. . |...  |  .    .....   ... |....|   |  .   .  |. |  |..||   
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltai.nlleav...

vRtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDS-SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
 |      |.|.||  |.||||   ||    .|||.     |. . |. ||..|.  |..  ||   .  . ||.
.r..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 175-414 5.4e-27 89.0 In-house 50-282 (302) alignment 
Range on Protein: 175-414
Range on HMM: 50-282/302.0
ENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIRDDKGKKTFIAAQAPNTASI---NDFWRLIWQENVCSVVMVTNILEGGKdRCTVYWPKEMGK
.| .||. ... . |. .| ||. .|    .|.||  .   . ... | || |.. |    ..|||...||.. |||..    |  |     ..||..|.
knlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

SKTFGGIEVKLRTIEEFSDHVhRVLDVKQVSGGETRSV--HQFHYQSWPDMGVPQypttliSYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFIS
 |..| . |  | .|. ....   . .  .  | . ||     . . |..  ||.      .|....| ...  . ..|.. ....    |.|| |.|..
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpv......kyaeliktaakvfakkikadentvivSknGaGRagaflt

LYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
|   . .. ... . |   ....|..||..|....||. .. ||.
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
0048076 (Phosphotyrosine protein) phosphatases II 264-413 7.1e-27 89.2 In-house 2-139 (145) alignment 
Range on Protein: 264-413
Range on HMM: 2-139/145.0
YWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantkgSTPMLVHCSAGVGR
||| |   .  .|.. . |.  .  . .. .||..     ...| . |..| .|||.|||. . .|..  . .......         |.||||||||||
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgR

TGTFISLYCMLAqvieeSRVDIFGFIQKMRKDRPNMVQTADQYILIHTAL
|||.. .|.||       .|...  ....|. ||..|.. .|.. .. ..
tgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 179-414 9.5e-26 85.6 In-house 22-256 (290) alignment 
Range on Protein: 179-414
Range on HMM: 22-256/290.0
KNRFKnIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKkTFIAAQAPNTAS-------INDFWRLIWQENVCSVVMVTNILEGGKD----RCTVYWPK
..| . .  . ..||||.  .    .||  ||..   .|   .|. |.| ..        |..|| .. ||.| .|||. .  |  ..     |. | |.
dqRle.vpLveatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

EMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVheritantkgSTPMLVHCSAGVGRTGTF
..|.. .|.|..||    |.  |  .| | ||   ..|   |    ...| .. |.. . ||.|  |.||             ||..|||  |. |  ..
svgeelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas..........ktpvivHcvdGiSrsAal

ISLYCMLAQVI-EESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
 ..      ..  .. | .   ....|| | .....| ..  .  ..|
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
PTPc_DSPc_SM00012 604-707 2.2e-25 84.2 In-house 1-104 (105) alignment 
Range on Protein: 604-707
Range on HMM: 1-104/105.0
TVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSIC
|||... .||    . | .  .||.|..|| .. . |. |.|.|.|| .|.||.|.|.|.. . ... .  ..||||| ||.||  ||.|... .||...
tvkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YEGMA
|. ..
yrall
0049260 (Phosphotyrosine protein) phosphatases II 511-703 2.5e-25 84.3 In-house 2-143 (152) alignment 
Range on Protein: 511-703
Range on HMM: 2-143/152.0
LNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWpnkdsvqfgplkvsiisaetirsdyvmrkfeikgpkkgtltvkQFQ
.. . ..  |.||| |.|.|. | |||. ..   .||||.||.  .|  |.||.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

LMGWDGNQkRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAekmitdSSVDIFQSVKRLRANRPSMIESVDQYSICY
 . |. .   | .   .| |.... ..    . .||.. ||  |.||.|...|.|           |.... |...|. || .... .|.  .|
hlpwpDhg.vpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 477-699 5e-25 82.9 In-house 52-270 (301) alignment 
Range on Protein: 477-699
Range on HMM: 52-270/301.0
DKNRFPNVlPMEKNRPCLVTkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLN-ELDLQDKSCAQYWPNK--DSVQFGP
||.|.|.| | . .    |   . |    | | ...|  . . |.||| ||. |. | | |.  .    ||||  ... . . |..| | |  .... | 
dkhryptv.PckPstavevi..vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

LKVSIISAETIRSDYVM-RKFEIKGP--KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVsecvRTSqaSGPIVLHCINGIGRSGVFAAIYSAAEKM
 |. | . |.| .. .. |..|..    |  | ||  .| . |  ..  | | | . .|.. |    . |    |||.|| .|||||  | .    | ..
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewt.drgvPkshaelfdlmelv....kks..ekPivvhcsaGiGrsvafigteylarev

ITDSSVDIFQSVKRLRANRPSMIESVDQY
 .|  ... ...|.|| .| . .  . | 
eadptieltealkhlrehrwngvqtnsql
0051082 (Phosphotyrosine protein) phosphatases II 503-704 1.9e-24 81.4 In-house 3-147 (151) alignment 
Range on Protein: 503-704
Range on HMM: 3-147/151.0
TDYINASFLNTFikkdvFLATQMPLPhttgDIWRMVCDWRSPVIVMLNELDLQDkSCAQYWPNKDsvqfgplkvsiisaetirsdyvmrkfeikgpkkgt
.||||.|..  .     ......||.    | .... ..   .||.|....  .  |..|.|. .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

LTVKQFQLMGWDGNqKRPASLAPILHLVDAVSEcvrtsQASGPIVLHCINGIGRSGVFAAIYSAAEKmitdssVDIFQSVKRLRANRPSMIESVDQYSIC
..|.......|.   . | |.. .|...... .     . .||.. ||  |.||.|...|.|  ...      |.... .. .|. || .. . .|. ..
ievlhipildwpdp.glplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YE
. 
lf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 177-418 2.2e-24 80.7 In-house 44-277 (312) alignment 
Range on Protein: 177-418
Range on HMM: 44-277/312.0
KAKNRFKNIVAFDHSRVVLETlkdDpHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKS----
|  ||. ||  .|  |  |     |    |  ||...     . |...|.|   ..  ||.|      .|..... ..| | ..|. |    .|      
kdlnrypniqcwdrgrftlag...d.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

-KTFGGIEVKLRTIEEFSD-HVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTlisytqtvkhVHERITANTKGSTPMLVHCSAGVGRTGTFISL
 . .     ..       |   |||| |   . |.   . .. . |||| |.|.   |           .  ..|  |   |.. |||||||||||.. .
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdt..........alrllsavkkdkkpviahcsagvgrtgtlali

YCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
  |.| .    . ..      .||||   |..  ||.    ...|  .
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0048179 (Phosphotyrosine protein) phosphatases II 305-411 1.7e-23 78.3 In-house 45-139 (144) alignment 
Range on Protein: 305-411
Range on HMM: 45-139/144.0
ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHEritantkGSTPMLVHCSAGVGRTGTFISLYCMLaqvieESRVDIFGFIQKMRKDRPNMVQTAD
..| ..|... .|||.|||.... |..  . .....|        . |.|||||||||||||.. .| |.     . .....  .. .|. ||..|.. .
leregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg

QYILIHT
|.. .. 
qlrfLle
subfamily_ptpA1_pd Subfamily ptpA1 445-663 1.1e-21 72.1 In-house 20-249 (418) alignment 
Range on Protein: 445-663
Range on HMM: 20-249/418.0
KLNIEQEFEILNQltpPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDvFLATQMPLPHTTGDIWRMVCDWRSP
  .|..|| .|..    |||          |  |||. |.||... |  |    .   .||||| ...    |. |..|| ||| |  |.|||| . |  
ihkikeefrllee...svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcr

VIVMLN-ELDLQDKSCAQYWPNKDS-VQ----------FGPLKVSIISAE-TIRSDYVMRKFEIKgPKKGTLTVKQFQLMGWDGnQKRPASLAPILHLVD
.||||. | .     | .|||..    |          ||   | ..        . . |.  .   .  |  . |.|  ||   .. |    |. .|. 
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt.fegetrditqyqyegwpd.hnipdhtqpfrqllh

AVS----ECVRTSQASGPIVLHCINGIGRSGVFAAI
...    . . .|.   ||..||  |.||.| |.. 
sitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 449-717 1.6e-21 71.2 In-house 27-298 (305) alignment 
Range on Protein: 449-717
Range on HMM: 27-298/305.0
EQEFEILNQLTPPVGPQ-AFKAAGLP-ANIDKNRFPNVlPMEKNRPCLVTKGEagSTDYINASFLNT-FIKKDVFLATQMPLPHTTGDIWRMVCDWRSPV
 .||  | . | |   | ||.|   .  .| |||. .| | . .   .. |     .||| | ..   .| .  |...| || .|  ..| || . .   
reefrglakytrpdmtqvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveq

IVMLN-ELDLQDKSCAQYWPNKDSVQFgPLKVSIISAETIRSDYVMRKFEIK-------GPKKGTLTVKQFQLMGWDGNQKRPASLAPiLHLVDAvsecV
||||   ..|    ||||||     .   ||  |.  .   |  . |  ||.          . ...|...|   |      |. |.  | |. |    .
ivmlcktvelgklkcaqywpaaqgekl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklts.lellsa....i

RTSQAsgPIVLHCINGIGRSGVFAAIYSAAEKMITDSSV-DIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM-KKF-DEYA
| |.   |||.||  ||||.|   ||    ||.  . ..  . . || || .|   |..  ||   .  | .|. .|. . ||
rgskv..pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 353-418 2.5e-21 69.8 In-house 1-66 (69) alignment 
Range on Protein: 353-418
Range on HMM: 1-66/69.0
MLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
|.||||.| |||||||..   .|..  |  ||||  .| ||| || ||    .||.|| |||||  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 459-568 2.6e-21 70.5 In-house 31-147 (392) alignment 
Range on Protein: 459-568
Range on HMM: 31-147/392.0
TPPVGPQafKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD--
 |.. ||  ..|  . |. |||. |.||....|  |    .   .||.|||....|  .  ..|.|.| . .  |.|||| . .   |.|...|.  |  
gpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkg

---KSCAQY----WPNKDS
   ...||.    ||.|| 
ddartvaqfhftewPdkdv
subfamily_egg_pd Subfamily egg 448-708 3.7e-21 70.1 In-house 16-268 (307) alignment 
Range on Protein: 448-708
Range on HMM: 16-268/307.0
IEQEFEILNQLtppVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
.|. .|.|...   |  .... |    | .| | . |   .  |  |  .    . |.| |  ..     . |. .| ||  |  | ||||   . . ||
lerrlevlees...vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv

MLNELdLQDKSCAQYWPN--KDSVQF--GPLKVSIISAETIR-SDYVMRKFEIKGPKKGTLTVKQFQlmgWDGNQkrPASLAPILHLVdavsEcvRTSQA
||.    . . |  |||.  .||...  | |..  .  .      . . |. . |...  . .. .|   .| |.   . .   |...       .  ..
mltsr.keserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnn..ssdvysplrvl....r..klrnl

SGPIVLHCINGIGRSGVFAAIYSAAEKMITDS--SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
| |.|...|.|. ..... ||  |  ...        . ..|. || .|.  .||| .|   |  .. 
skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
0044763 (Phosphotyrosine protein) phosphatases II 486-704 5.1e-21 70.5 In-house 1-165 (178) alignment 
Range on Protein: 486-704
Range on HMM: 1-165/178.0
PMEKNRPCLVTKGEAGSTDYINASFLNTFikkdVFLATQMPlphttGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSvqfgplkvsiisaeti
|.. .| .| .     ..||||||.   .    ..|... |      | .......   .||.|.| .     .| .||| . .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

rsdyvmrkfeikgpkkgtltvKQFQLMGWDGNQKRPaSLAPILHLVDAVSECVRtsQASGPIVLHCINGIGRSGVFAAIYSAAEKmitdsSVDIFQSVKR
                      |.. ......   . .|. .| .|... |..   .  ||.. ||  |.||||...|.|   .      ...... ...
.....................iqylhipipDhgvpd.llehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRANRPsMIESVDQYSICYE
.|. || .... .|.  .||
vrerRp.ivpnpgqlrqLye
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 355-420 2.3e-20 66.7 In-house 2-67 (69) alignment 
Range on Protein: 355-420
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSG
||||.| |||||||..   .|..  |  ||||  .| ||| || ||   ..|..|| |||||   |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 216-410 4.4e-20 66.7 In-house 2-197 (199) alignment 
Range on Protein: 216-410
Range on HMM: 2-197/199.0
KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRV--LDVKQVSGGETRSVHQFH
||.. .||.| |   .. |||...|.     .||| .     .    .|||     .  .| . |  .||   .|..  .  |  .  .   || . .. 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YQSWPDMGVPQYpTTLISYTQTVKHVHERITANtkGSTPMLVHCSAGVGRTGTFISLYCMLAQvIEE---SRVDIFGFIQKMRKDRPNMVQTADQYILIH
. || .   |.  . .. .  . . |  .   .    .|..|||| | | || |..|   .    ||   | ||.|   ...|. |  .. . ..| .|.
ftswkekttpnv.alfvgfvvasrevskkyeqe..kdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 224-422 5.9e-20 65.9 In-house 96-293 (302) alignment 
Range on Protein: 224-422
Range on HMM: 96-293/302.0
AQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTI----EEFSDHVHRVL-----DVKQVSGGETRSVHQFHY
   |   ... .| || | ||. || .... |... .|. |. ...|.  .||   ||   .    |||.|  . .|       ...     ..|. ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

QSWPDMGVPQYPTTLIsytQTVKHVhERItantKgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
 .||| | |. . | .   . .|.  |      |  . .|||||||||||||....   .    ..   |.   .. .|. |   ||...| | .   . 
sawpdhGapkeaytal...dilkfc.esy....k..knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt

EAYMSGNT
 . |   .
kglmekag
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 216-410 7e-20 66.0 In-house 1-196 (198) alignment 
Range on Protein: 216-410
Range on HMM: 1-196/198.0
KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRV--LDVKQVSGGETRSVHQFH
||.. .||.| |   .. |||...|.     .||| .     .    .|||     .  .| . |  .||   .|..  .  |  .  .   || . .. 
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YQSWPDMGVPQYpTTLISYTQTVKHVHERITANtkGSTPMLVHCSAGVGRTGTFISLYCMLAQvIEE---SRVDIFGFIQKMRKDRPNMVQTADQYILIH
. || .   |.  . .. .  . . |  .   .    .|..|||| | | || |..|   .    ||   | ||.|   ...|. |  .. . ..| .|.
ftswkekttpnv.alfvgfvvasrevskkyeqe..kdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 467-707 7e-20 65.8 In-house 29-266 (281) alignment 
Range on Protein: 467-707
Range on HMM: 29-266/281.0
FKAAGLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWP
  .   | |  |||. |.  ..  |  |     .  ||||| | .. . . |  .. || |   |  |.|||. .  .  |||| .. . . . ||.|.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

NKD--SVQFGPLKVSIiSAETIRSDYVMRKFEIKGPKKgTLTVKQFQLMGWDGNQkRPASLAPILHLVDAVsecvRTsqASGPIVLHCINGIGRSGVFAA
 .    .||  | ||     |.    |  ....    . |  . ..    |   |  | |   .|...  .    |.   | | |.||  |.|||| . |
rnahcclqfdklsvsy.edstvnkslvttrlnlsyege.trlithwlwkewpdwq.vpessevmlkilrki....ra..rstppvihcsagvgrsgtlma

IYSAAEKMITDSS-VDIFQSVKRLRA-NRPSMIESVDQYSICYEGMA
.  | . . .  .  || | | .||   | . .....|| . .. . 
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 175-418 7.1e-20 65.8 In-house 46-280 (303) alignment 
Range on Protein: 175-418
Range on HMM: 46-280/303.0
ENKAKNRFKNIVAFDHSRVVLEtlkDdphSDYYNANYIRDDKGKKTfIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKsKT
.|  |||| ... .|||.| |    |   | |  |.|.  |  ||. | .| | . .  |||..| ...|  |...    |  |    . .|..      
knmdknrfvdvicldhskvkls...d...ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lk

FGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRS-VHQFHYQSWPDMGVPQYPTTliSYTQTVKHVHERITANTKgSTPMLVHCSAGVGRTGTFISLYC-
|    ...  . .       || |  || |. .| .|  ||..||   .|   .    . . .  .   .   .. ||| .    .|.||.|||  .   
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysd.stptvymslsgcgragtfalfeta

MLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
 |.   |.. .|.   ....|. |   ||   |. ...| | |  .
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 472-710 1e-19 65.6 In-house 32-270 (285) alignment 
Range on Protein: 472-710
Range on HMM: 32-270/285.0
LPANIDKNRFPNVLPMEKNRPCLVTKgeagSTDYINASFLNTFIKK-DVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK--D
  || | ||. .|  .|. |  |  .      ||| ||..    |    ...|| ||| |  |.|.|. . .   ..||  | .   . || |.|.|  .
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

SVQFGPLKVSIISA--ETIrSDYVMRKFEIK---GPKKGTLTVKQFQLMgWDGNQKRPASLAPILHLVDAVSECvrtSQASGPIVLHCINGIGRSGVFAA
 |.||  ....  .  |.| .  ..  . .          | ... |.  |  .|  |    |.. |   | .         ||..||  |.||.  |  
vvkfgkyeitlteckeeai.agtilnaltvintedasseplymnhvqvp.wwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrtatfvg

IYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
|  |. ... .  ..... |. .|| |   ..|  |. . |  . ||.
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 175-300 1.3e-19 65.1 In-house 46-184 (350) alignment 
Range on Protein: 175-300
Range on HMM: 46-184/350.0
ENKAKNRFKNIVAFDHSRVVLE-TLKD-------DPHSDYYNANYIRDD----KGKKTF--IAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDR
|  ||||.|||. ..|||| |. .||           .|| ||||..      . .  |  ||.|||    ..||...| . .|  ....|.  | . ..
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CTVYWPKEMGKSKTFgGIEVKLRTIEEFSDHVHRVLDVKQ
|  ||..   . .|   .. | . | .  | . .. |||.
cyrYWqegsydditv.klaskwenimgindsslysadvkk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 465-712 1.4e-19 65.0 In-house 41-289 (305) alignment 
Range on Protein: 465-712
Range on HMM: 41-289/305.0
QAFKAAglpANIDKNRFPNVLPMEKNRPCLvtkGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYW
.||| |    . .|||. .|  ...||  |     .   .|| | .. |  .   |. || || .|  |.| |  . .   | || | |.   | |..|.
kafkea...qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyf

PNKD--SVQFG--PLKVS--IISAETIR--S--D--YVMRKFEIKGPKKGTLTVKQFQLMGWDGNQKrPASLAPILHLVDavsecvRTSQASGPIVLHCI
. ||   ..|     |.|  . |..|..  .  .      .. |.|| . .. |...  . |      ||.   || |.       ..  . ||||.|| 
askdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv.paadlailelle......karpskgpivvhcs

NGIGRSGVFAAIYSAAEKMITDSSVDIFQ-SVKRLRANRPSMIESVDQYSICYEGMAEYMKK
 ||||.|    .    .....   ..  .  ....| .|   |.. .|| . .. . .|..|
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 479-707 1.4e-19 65.3 In-house 23-256 (290) alignment 
Range on Protein: 479-707
Range on HMM: 23-256/290.0
NRFPNVLpMEKNRPCLVTKGEAGSTDYINASFLnTFIKKDVFLATQMPLPHT-------TGDIWRMVCDWRSPVIVMLNELDLQDKS-----CAQYWPNK
.| .. | .|..|  |   |.  . ||| |... |. .   ...|| |. ..         . | |. . ..  .||| | . ...      ||.| |..
qRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

D--SVQFGPLKVSIiSAETIRSDYVMRKFEIKGPKKGTLTVKQFQLMGWDGNQKRPASlAPILHLVDAVSeCVRTsqasgPIVLHCINGIGRSGVFAAIY
   ...|. |.|.         |  .|. ..|  ..  .||.  .| ||.  . .. .   .|.|.. |  . .|     |...||..|| || ..||| 
vgeelkfkgltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedt.ktllsliqkvk.askt.....pvivHcvdGiSrsAalaaii

SAAEKMI-TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMA
 .  |.. | .|| . . .| || .|  .| |  ...    |. 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 304-414 2.2e-19 64.4 In-house 212-341 (350) alignment 
Range on Protein: 304-414
Range on HMM: 212-341/350.0
GETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHV----HERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLA------QVIEES---------RVD
 .   |.|.... |.|...   |  ...  .  ...      .   ... |.|.|||||||||||||...|  .|       .. .||         |  
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IFGFIQKMRKDRPNMVQTADQYILIHTALV
|.  ....|| | .|||. ||.| |. || 
isiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 446-712 6.8e-19 62.4 In-house 26-287 (302) alignment 
Range on Protein: 446-712
Range on HMM: 26-287/302.0
LNIEQEFEILNQLTPPVG-PQAFKaaglpANIDKNRFPNVLPMEKNRpclvTKGEAGSTDYINASFLNTF-IKKDVFLaTQMPLPHTT---GDIWRMVCD
 ....||. ....  ..   .|||     .|..||. ..|  ...|.     |.||   .|.||| ..   ... ..| .|.|   ..    . |||| .
aevkkefkkidtmkvdlekCkafk.....knlkknqsedvpildsnl....vkleaepdsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfq

WRSP-VIVMLNELDLQDkSCAQYWP--NKDSVQFGPLKVSIISAETIRSDYVMRKFEIK--GPKKGTLTvKQFQLMGWDgNQKRPASLAPILHLVDAVse
 .   | ... | .|.  .  ...|    | ...| . | .   |    .  .   |.   |     |. .   |  |  ..| | . | . . .  |  
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvla.nvyvltnWk.qkkvpvkyaeliktaakv..

CVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
 .....|. ..|.   ||.|| |.| .   | ||. ... . | . || .|..||....|..||   |  .. |.||
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 214-406 7e-18 59.6 In-house 39-210 (255) alignment 
Range on Protein: 214-406
Range on HMM: 39-210/255.0
DdkgkktfiaaqapntaSINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVklRTIEEFSDHVHRVLDVKQVSG--GETRSVHQ
                 ... |.. | | .   |||...  | |...|  |.| |  . . .  ..|   | .  .| | | |..    |   .|. |. 
l................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnv..tttkssadvvlrtleitstlgekkkthtvkh

FHYQSWPDMGVPQYPTTLISYTQTVkhvheritANtkgSTPMLVHCSAGVGRTGTFI---SLYC-MLAQVI--EESRVDIFGFIQKMRKDRPNMVQTADQ
..|. |..   |. .  .    . |         .   | ...||||.|.||. .|.   ..|  |. ..   |   .|   .....|. |.  ..|  |
ysykGWieknaPelareilnilkvv........rd...sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

Y
 
l
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 470-710 1e-17 58.8 In-house 42-279 (303) alignment 
Range on Protein: 470-710
Range on HMM: 42-279/303.0
AGLPANIDKNRFPNVLPMEKNRPCLvtkgeaGSTDYINASFLNTFIKKDVFLaTQMPLPHTTGDIWRMVCDWRSP-VIVMLNELDLQDKSCAQYWP-NKD
  .  |.||||| .|. ... .  |        . || ||.|.   .|   | ||.||.||. |.|.|. . .   |...| . . ..      .| |.|
nqfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

SVQFGP--LKVSIISAETIRSDYVMRKFEI-KGPKKGTLTVKQFQlmGWDGNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIY
 ..|    ..|  .    .   .|..   . .|  |  | |....   |  |.    . . ... .  .   .|    | | |   . | ||.| || . 
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe

SAAEKMIT-DSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
.|   . . ..|.|. . .. .|  |   .. . |.|. |  .||..
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 519-704 1.1e-17 58.8 In-house 5-197 (198) alignment 
Range on Protein: 519-704
Range on HMM: 5-197/198.0
VFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNElDLQDKS--CAQYWPNKDSV--QFGPLKVSIiSAETIRSDYVMRKFEIKG---PKKGTLTVKQFQLM
 ..||| || .|  |.|.|| .  |  |||.|. | ..|    . |||  .|   ..| | |.   . | ..||..  . .         |  . ..|. 
ryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvtt.ktittkpdytitaliltnnttappstreishyqft

GWDgnQKRPASLAPILHLVDAVSECVRTS--QASGPIVLHCINGIGRSGVFAAIYS--AAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
 |   .|    .| .. .| |  |  .    .   |...|| .| | .||| |.     . .    | ||.|.  ||||  |  .| |...| . |.
swk..ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 519-704 1.2e-17 58.8 In-house 6-198 (199) alignment 
Range on Protein: 519-704
Range on HMM: 6-198/199.0
VFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNElDLQDKS--CAQYWPNKDSV--QFGPLKVSIiSAETIRSDYVMRKFEIKG---PKKGTLTVKQFQLM
 ..||| || .|  |.|.|| .  |  |||.|. | ..|    . |||  .|   ..| | |.   . | ..||..  . .         |  . ..|. 
ryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvtt.ktittkpdytitaliltnnttappstreishyqft

GWDgnQKRPASLAPILHLVDAVSECVRTS--QASGPIVLHCINGIGRSGVFAAIYS--AAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
 |   .|    .| .. .| |  |  .    .   |...|| .| | .||| |.     . .    | ||.|.  ||||  |  .| |...| . |.
swk..ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 599-711 1.8e-17 57.9 In-house 274-386 (392) alignment 
Range on Protein: 599-711
Range on HMM: 274-386/392.0
KKGTLTVKQFQLMGWD--GNQKRPASlAPILHLVDAVSECVRtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESV
 | . || |.|. ||   | .... .   .|.|. ||      |.    |..||. | ||.||| .      ..    ||||||.|| |||.|  .... 
lkashtvtqyqfhgwpkhgsdqqsga.rsllkliravkgstn.skkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqte

DQYSICYEGMAEYMK
..|.. |. . ||..
eeyafvydvireylh
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 502-710 1.3e-16 55.5 In-house 66-271 (288) alignment 
Range on Protein: 502-710
Range on HMM: 66-271/288.0
STDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK--DSVQFGPLK-VSIISAETIRSDYVMRKFEIKG
.  ||.|  . .   |  .. .| ||  | . .|.|. .     ||||.|| ..  .  |.|.| |  .....| |  |   . . |    ..  . |. 
pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllrisk

PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVsecvrtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVD
. . .  ||.  |  || ..  | .  . |.|.. .       .   |||.|. .|.||.| .. |  |.| .  |  . | . ...||..|   |..  
egeekvivkilhlleWd.ddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem

QYSICYEGMAEYM
||   .  . |..
qylyvhrcvleel
subfamily_CG42327_pd Subfamily CG42327 472-569 3.8e-16 53.7 In-house 25-124 (319) alignment 
Range on Protein: 472-569
Range on HMM: 25-124/319.0
LPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKK-DVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSV
 ..  ||.|. ||.|. . |. |  .|.  .. |..||..  . .    ..|.|..|  .. | ||.| . .| ||| | .|  .  | ||.|.| |.. 
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl
0048179 (Phosphotyrosine protein) phosphatases II 604-704 2.7e-15 51.8 In-house 48-139 (144) alignment 
Range on Protein: 604-704
Range on HMM: 48-139/144.0
TVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRtsqASGPIVLHCINGIGRSGVFAAIYsaaekMITDSSVDIFQSVKRLRANRPSMIESVDQYSICY
.. |.. ..|...   | .|. .|...... |...    .||.. ||  |.||.|...|.|     ..    ..... ....|. || .... .|.  ..
egiqylhlpwpDh.gvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrrpgavpnpgqlrfLl

E
|
e
0048076 (Phosphotyrosine protein) phosphatases II 602-704 4.2e-15 51.2 In-house 44-137 (145) alignment 
Range on Protein: 602-704
Range on HMM: 44-137/145.0
TLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSqasGPIVLHCINGIGRSGVFAAIYSAAEkmitdSSVDIFQSVKRLRANRPSMIESVDQYSI
. .. |.. ..|...   | .|. .|...... |...     ||.. ||  |.||.|...|.|   .      .|.... ....|. || ......|.  
erlgiqylylpwpDh.gvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

CYE
.||
lye
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 477-567 6e-15 49.8 In-house 49-154 (350) alignment 
Range on Protein: 477-567
Range on HMM: 49-154/350.0
DKNRFPNVLPMEKNRPCLV--------TKGEAGSTDYINASFLNTF-----IKKDV-FLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELD-LQDKSCAQ
 |||. |.|| |..|  |          |    . |||||..|.       |. |  ..||| ||| |  | ....     .||..|.... |. . | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNKD
||.. .
YWqegs
subfamily_hpo-7_pd Subfamily hpo-7 229-413 2.4e-14 47.9 In-house 44-223 (263) alignment 
Range on Protein: 229-413
Range on HMM: 44-223/263.0
TASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVklRTIEEFSDHVHRVLDVKQVSG--GETRSVHQFHYQSWPDMGVPQYP
   |. |.. | | .   |||...  | |...|  |.| |  . . .  ..|   | .  || . . |.. .. |   .|. |... |. |..   |. .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

TTLIsytQTVKhvherItanTKGSTPMLVHCSAGVGRTGTFI---SLYC-MLAQVIE--ESRVDIFGFIQKMRKDRPNMVQTADQYILIHTAL
   .   . .|     .   ...| .. ||||.|.||.  |    ..|  |. .. .     .|   .....|. |.  ..|  |       .
reil...nilk.....v...arnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 133-213 5.5e-14 46.3 In-house 6-84 (440) alignment 
Range on Protein: 133-213
Range on HMM: 6-84/440.0
IAVVNLVEHVEKKKaqDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIR
| |......|....      |  |. ||||       .|  |.|| |||..||.|.|||||.|| .|  |.||| || || 
iivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 308-415 1.1e-13 45.2 In-house 219-342 (349) alignment 
Range on Protein: 308-415
Range on HMM: 219-342/349.0
SVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVH----ERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLA------------QVIEESRVDIFGFIQK
 . |. .. |.|...   | ...   .  ...      |   .|. ....||||||| ||||... |  .|.            ..    .  |.  . .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

MRKDRPNMVQTADQYILIHTALVE
.|| | .|||   |.| |. ||..
lrkqrismvqnlaqfiaiyealLk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 175-292 1.5e-13 44.8 In-house 47-175 (349) alignment 
Range on Protein: 175-292
Range on HMM: 47-175/349.0
ENKAKNRFKNIVAFDHSRVVLETLKDDP--------------HSDYYNANYIRDDK--GKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGK
|  ||||.|.|. ..||||.|.     .                || ||||..  .   .| .|| |||  ....||...|  ..|  |. ...  | . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

DRCTVYWpkemgKSKTFGGIEVKLRTIEEFSDHV
..| .||     .  .. .|.|||.   ...  |
ekcdiyw.....qelsysnitvklqnsslyianv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 530-693 2e-13 45.0 In-house 40-204 (255) alignment 
Range on Protein: 530-693
Range on HMM: 40-204/255.0
TTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWPNKDSVQFGPLKVSIISAEtIRSDYVMRKFEIK---GPKKGTLTVKQFQLMGWDgNQKRPASLAP
|    ....   .. |.||| ..   . . | .|.| .   .    .|......   .| |.|  ||    | || | ||| ..  ||  ... |     
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWi.eknaPelare

ILHLVDAVsecvrtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMITD----SS--VDIFQSVKRLRANRPSMI
||... .|       . | ..|.|| .|||||  |. . ..  |||      .   .|  . .. || .|.. |
ilnilkvv.......rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkrai
subfamily_eak_pd Subfamily eak 169-416 2.3e-13 44.2 In-house 45-304 (332) alignment 
Range on Protein: 169-416
Range on HMM: 45-304/332.0
TVAMKPENKAKNrFKNIVAFDHSRVVLETLKDDPhSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKE
... . |.  .|   .|| .|.  | | . . ..   | ||  .   .  . .| . ...   .  ||... ...  ..|.. . .| . ..   |.|..
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

MGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQvsGGETRSVHQFHYQSWPDMGVPQYPTtLISYTQTVKHVHERITANTKG---------------STPM
  .   || ..|. .   . .    | | ...  | ||  |. ...  | .. .|.|   .... ...|.|     ...|                |   
treelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpkyed.flalrkvmkevGvlllivmksallsstlkkyihtppsfap

LVHCSAGVGRTGTFISLyCMLAQVIEESRVDIF---GFIQKMRKDRPNMVQTADQYILIHTALVEA
.. .. |  |.|.|. .  .| ..|.. . . .    .| |... |   | .| |. .|. .... 
iiqsarGsaraGvfvvi.dllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_CG42327_pd Subfamily CG42327 631-712 3.8e-13 43.8 In-house 235-317 (319) alignment 
Range on Protein: 631-712
Range on HMM: 235-317/319.0
DAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
  .|    | .  ||.|.|| .|.||.|.  |   | ... .   |||| | |  .| .| | . ...||   |  . || ||
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_CG42327_pd Subfamily CG42327 349-414 6.3e-13 43.1 In-house 246-312 (319) alignment 
Range on Protein: 349-414
Range on HMM: 246-312/319.0
GSTPMLVHCSAGVGRTGTFISLYcMLAQVIEES--RVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
   |. |||| ||||||. |.   .  . .|||   |||   .. .|.|| . |.| .|| .|.  | 
sqGPlvvhcsdGvGrtGlviasd.iairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 464-569 7.4e-13 43.0 In-house 22-128 (297) alignment 
Range on Protein: 464-569
Range on HMM: 22-128/297.0
PQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtKGEAGSTDYINASFLnTFIKKD---VFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SC
...| .|  .. . |||. ..| ....|  |  ..    .||||| .. .| ...    .. .| ||  |  | |..| .    ||||. .|  . .  |
gesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyv.vfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

AQYWPNKDSV
| |||. .  
apywpsvvqe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 463-570 1.2e-12 42.0 In-house 84-185 (244) alignment 
Range on Protein: 463-570
Range on HMM: 84-185/244.0
GPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvTKGEAGSTdYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDkscaQY
 |  .| |  | |  |||    ||.. ||  | .||  | | ||||||.  . .   .. || ||  |. |.|.|. .    |.|.|  .. .|    .|
dpsvmkdafnpnnswknregaglpfdfnrvpl.skgsmgnt.yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....ey

WPNKDSVQ
||. . ..
wpdseple
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 474-576 1.9e-12 41.3 In-house 51-154 (310) alignment 
Range on Protein: 474-576
Range on HMM: 51-154/310.0
ANIDKNRFPNVLPMEKNRPCLvTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSV-QF
 .. |||. .|. ... |  | .   .   ||| | ...|   .. |. .| || ||  |.|||. . |.  |..|     . .  |  |||       .
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GPLKV
| ..|
gcirv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 135-225 6.8e-12 39.4 In-house 7-94 (95) alignment 
Range on Protein: 135-225
Range on HMM: 7-94/95.0
VVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphSDYYNANYIRDDKGKKTFIAAQ
|  .  || . ... .. |  ||  ..   | . ||     |  |||| ||. .| .|||| | .|   ||| || ..     |. .||||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaq
subfamily_hpo-7_pd Subfamily hpo-7 532-691 1.1e-11 39.2 In-house 48-208 (263) alignment 
Range on Protein: 532-691
Range on HMM: 48-208/263.0
GDIWRMVCDWRSPVIVMLNELDLQ-DKSCAQYWPNKDSVQFGPLKVSIISAETIRsDYVMRKFEIKG---PKKGTLTVKQFQLMGWDgNQKRPASLAPIL
  .....   .. |.||| .   .  . | .|.| .   .    .|.. .....  | ...  |.      || | |||...  ||  ... |     ||
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWi.ekndpelareil

HLVDAVsecvRTsqaSGPIVLHCINGIGRSGVFAAIYSAAEKMITD----SS--VDIFQSVKRLRANRPS
......    |    | ..| || .|||||  |. . ..  |||      |   .|  . .. || .|..
nilkva....rn...skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 175-258 2.2e-10 34.6 In-house 36-121 (347) alignment 
Range on Protein: 175-258
Range on HMM: 36-121/347.0
ENKAKNRFKNIVAFDHSRVVLET-----LKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMvtnILEGGK
 . .||| |.    | .||||        . |.   | || .|. |. .| .| .| |   .. |||...   .|  ||    |.|  |
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt...ifepik
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 477-711 2.5e-10 34.5 In-house 45-277 (312) alignment 
Range on Protein: 477-711
Range on HMM: 45-277/312.0
DKNRFPNVLPMEKNRPCLVTKgeagSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWpnKDSVQFGPLK
| ||.||.   .. |  |          || | |..   | . |..|| ||  |.  .|...    |  |..|  . .   . ||.|    | | |  |.
dlnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgfvdle

VSIISAETIRsdyvmrKFEIKGPKKGTL----------------TVKQFQLMGWDgNQKRPASLAPILHLVDAVSecvrtsQASGPIVLHCINGIGRSGV
   . .|         . || |  |  .                 ....|   |  ..  | |    | |. ||       .   |.. ||  |.||.| 
dhrvyteyct......eieiggkskdkithrvlkvvvkatgqesklnhyqwaswp.dhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgt

FAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.| | |    .      .. .|   || .|   .. . ||  .   . |.. 
laliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_eak_pd Subfamily eak 473-614 4.7e-10 33.4 In-house 50-190 (332) alignment 
Range on Protein: 473-614
Range on HMM: 50-190/332.0
PANIDKNrFPNVLPMEKNRPCLvTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYWPNKD--SV
  ....|   ...| ...   | |        ||||| ..       .. | ..        |.|| . .|| ||.| ....|. .   .|.|.|    .
leavnrn.vvkivpydrylvrl.tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

QFGPLKVSIISAeTIRSDYVMRKFEIKGPkKGTLTVKQFQLMGWD
.|| |.|   .    |. . .|..|..     |  |. ... || 
kfGildverkef.vkrniletrllelskG.nethrvlhykvfGwt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 446-524 5.3e-10 33.4 In-house 19-94 (95) alignment 
Range on Protein: 446-524
Range on HMM: 19-94/95.0
LNIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEagsTDYINASFLNTFIKKDVFLATQ
 | .|||.   .  .     .. .    ||| |||| |..| .  | .| || .   .||||| |.. . .|....|.|
snsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 602-710 7.7e-10 33.0 In-house 214-344 (350) alignment 
Range on Protein: 602-710
Range on HMM: 214-344/350.0
TLTVKQFQLMGWDGN--QKRPASLAPILH----LVD-AVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAE-----KMITDSSVD----------IF
 . | |.|.  |       .| |. ..|     |.|  ..|    .. | ||. ||  |.|| |.. .. |  .     ...|. |.           |.
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

QSVKRLRANRPSMIESVDQYSICYEGMAEYM
. |..||  | ||. ..||. ..|| .  | 
iivnelrkqrismvqnldqfifiYeallfyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 218-299 1.2e-09 32.0 In-house 235-312 (440) alignment 
Range on Protein: 218-299
Range on HMM: 235-312/440.0
KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNIlEggKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVK
|..|||.| |  ... |||||. . .. ...|. .. .     |..||| .  .| ||| . |  .  |..     | |..|
knafiatqmpldstvldfwrlvhdyristiimlnql.n..dktcsiywpvn.trsvtfgpftvghkgsenmnrvkvrtlelk
0038934 (Phosphotyrosine protein) phosphatases II 313-407 1.4e-09 33.4 In-house 81-167 (194) alignment 
Range on Protein: 313-407
Range on HMM: 81-167/194.0
HYQSWPDMGVPQYPtTLISYTQTVKHVHERITANTKGstPMLVHCSAGVGRTGTFISLYCMLAQVIeeSRVDIFGFIQKMRkdrPNMVQTADQYI
.| ..| ..    | .|  ... .. |.| . ....|    .||| ||.|||||..  | .  . .  |  .  .... .|   |..... |.. 
eylklpfpddgtvP.sleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyrlgm..saeeAialfrekR...pgaipnqdyle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 647-711 1.9e-09 31.7 In-house 1-65 (69) alignment 
Range on Protein: 647-711
Range on HMM: 1-65/69.0
VLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|.||  | ||.| | ||     .. ..  ||||  |. .|  || |.   ..|   .. ..| .|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 224-419 2.4e-09 30.3 In-house 120-310 (346) alignment 
Range on Protein: 224-419
Range on HMM: 120-310/346.0
A---QAPNTASINDFWRLIWQENVCSVVMVTNiLEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDM
|   |  | . ..||| .|.||..  | ..    .  |.  |  .  | |  .  | . .. |  .   |     ..|      ..  ..  |.  |  .
aqlpqmenesfvedfwymiyqeqihlvylmvp.ddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhl

gvPQYPTTLisytQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHtALVEAYMS
   | | ||      .| .|.  . .   .. . |    | ||. .||     . |. .    .|.  .......||  |..  ||  |. |.|  |..
..qqppktl....piikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy.aivfdyia
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 176-275 3.5e-09 30.6 In-house 34-131 (332) alignment 
Range on Protein: 176-275
Range on HMM: 34-131/332.0
NKAKNRFKNIVAFDHSRVVLEtlKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTA-SINDFWRLIWQEnVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
|   ||   . .|||||| |    .| . |.|||...     | ..| ||||    .   |||.. .    |...|   ..  . | . |   . |  |.
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvser.kpsmilvfgdidekqkrkapydisdrgfeks

F
|
f
subfamily_PTPDC1_pd Subfamily PTPDC1 313-409 3.8e-09 31.2 In-house 86-168 (182) alignment 
Range on Protein: 313-409
Range on HMM: 86-168/182.0
HYQSWPDMGVPQYPTTLisytQTVKHVHERITANtkgstPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVdifgfIQKMRKDRPNMVQTADQYILI
.  .|.| ||.   . |    . || |.  .. .      . ||| || ||||  |. | . |. .. ..      |...|. ||. .|| .|  |.
ynfgwkDygvasleriL....divkvvafalqeg.....kvavhChaGlGrtGvliacylvyakrltaeka.....iklvrskrpksiqtreqvelv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 647-711 4.1e-09 30.7 In-house 2-66 (69) alignment 
Range on Protein: 647-711
Range on HMM: 2-66/69.0
VLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|.||  | ||.| | ||     .. ..  ||||  |. .|  || |.    .|   .. ..| .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
0048567 (Phosphotyrosine protein) phosphatases II 306-410 8.6e-09 29.9 In-house 27-132 (157) alignment 
Range on Protein: 306-410
Range on HMM: 27-132/157.0
TRSVHQF-------HYQSWPDMGvPQYPTTLISYTQTvkhVHERITANTKGSTPMLVHCSAGV---GRTGTFISLYCMLAQVIeesrvDIFGFIQKMRKD
. ....|       ..  . | | |   ..|... .    ... .   .. . .  |||.||    |||.|.|..|..| . .     .   .|. .|  
lynalyFsiddglvyedfffdfG.PlnlailyrFilk...lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf.....tpeeaiaplriv

RPNMVQTADQYILIH
||..|   |.. |..
rpgsvpfrdasylls
PTPc_motif_SM00404 328-379 1.6e-08 29.5 In-house 58-109 (140) alignment 
Range on Protein: 328-379
Range on HMM: 58-109/140.0
TLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIE
.    ..  . | . | . .|  .  |||| ||| |..|.|  |.|  . ..
ekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqls
0038934 (Phosphotyrosine protein) phosphatases II 622-709 1.6e-08 29.9 In-house 95-176 (194) alignment 
Range on Protein: 622-709
Range on HMM: 95-176/194.0
SLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYsaaekMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEY
||. .|. .|.| | ..  ...| .. ||  |.||.|...| |     .|     .  ......|  ||..|...|.... .. . |.
sleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaY.....LiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 644-706 6.3e-08 26.8 In-house 229-291 (297) alignment 
Range on Protein: 644-706
Range on HMM: 229-291/297.0
GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGM
 ....||  |.|||||       ..|.  .   |.   .. || .|. ......|. ..|. .
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 145-215 7.7e-08 26.2 In-house 7-77 (244) alignment 
Range on Protein: 145-215
Range on HMM: 7-77/244.0
KKAQDQDGFAHEF-GLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDpHSDYYNANYIRDD
 . ||..   .|| ||      . .| |.   | .|||. ||. ||..||.| . | .  ||| |||||.  
srlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgs
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 472-553 8.6e-08 26.0 In-house 31-111 (332) alignment 
Range on Protein: 472-553
Range on HMM: 31-111/332.0
LPANIDKNRFPNVLPMEKNRPCLVTKgeAGSTDYINASFLNTFIKKDVFLATQMPLP-HTTGDIWRMVCDWRSPVIVMLNELD
.  |.| || | .  ....|  |  .   |  |. |||... . ||  .. .| |.  ||   .|||| . .  .|... ..|
flnnmdmnriphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid
DSPc Dual specificity phosphatase, catalytic domain 310-398 1.9e-07 26.0 Pfam-A 33-116 (133) alignment 
Range on Protein: 310-398
Range on HMM: 33-116/133.0
HQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIeeSRVDIFGFIqkmRKDRPN
.... ..  ....|.  .|    ..  . . | | . ..     |||| ||. |..|.|  | |  . .  |  . . |.   ...|..
naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl..slneAyefv...kerrsk
DSPc Dual specificity phosphatase, catalytic domain 310-398 1.9e-07 26.0 In-house 33-116 (133) alignment 
Range on Protein: 310-398
Range on HMM: 33-116/133.0
HQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIeeSRVDIFGFIqkmRKDRPN
.... ..  ....|.  .|    ..  . . | | . ..     |||| ||. |..|.|  | |  . .  |  . . |.   ...|..
naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl..slneAyefv...kerrsk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 502-566 1.9e-07 24.8 In-house 89-156 (349) alignment 
Range on Protein: 502-566
Range on HMM: 89-156/349.0
STDYINASFLN--TFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELD-LQDKSCAQYWPNK
  ||||| .|.   .  .  ..|||.||| |  | ....   . .... ||. . |. . | .|| . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_CDC14_pd Subfamily CDC14 342-409 2.8e-07 24.7 In-house 257-317 (328) alignment 
Range on Protein: 342-409
Range on HMM: 257-317/328.0
RITANTKGStpMLVHCSAGVGRTGTFISLYCMLAQvieesRVDIFGFIQKMRKDRPNMVQTADQYILI
.|. ...|.  . ||| ||.|||||.|. | |        |.     |  .|  || .| .  |  |.
eiaekaeGa..iavhCkaGLGrtGtLiacylmkhy.....rftaaeaiawlricrPGsvigpqqkfle
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 503-590 2.8e-07 24.9 In-house 13-96 (130) alignment 
Range on Protein: 503-590
Range on HMM: 13-96/130.0
TDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDkscaQYWPNKDSVQFGPLKVSIISAETIRSDYVM
 .||||||.    .   .| || ||  |. |.|.|. .    |.|.|  .. .|    .|||. . ...   .. . ...   .... 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknik
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 549-706 3.1e-07 24.2 In-house 140-298 (332) alignment 
Range on Protein: 549-706
Range on HMM: 140-298/332.0
LNELDLQDKSCAQYWPNKDSVQFGPlKVSiISAETIRSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDGNQKRPASLAPILHLV--DAVSECVRTSQASGP
|.| .|. | | ..||.| | .  |  .| | |   .|.  |. |..    ||       ...  |    | |  .  .   .  . .    .|  . ||
leecelkakicrkfwpekrskkdfp.als.iqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigp

IVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGM
|.| |  |. .  ..|.|     ..  .  | . ...  .. .|   . .|  || . | .
imlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystaceml
subfamily_DSP23_pd Subfamily DSP23 319-410 4.6e-07 24.6 In-house 56-139 (148) alignment 
Range on Protein: 319-410
Range on HMM: 56-139/148.0
DMGVPQY-PTTLisyTQTVKHVHERITANTKGSTpMLVHCSAGVGRTGTFISLYCmlaqvIEESRVDIFGFIQKMRKDRPNMVQTADQYILIH
 .....| | .|    | |. |.    |. |. . . |||  | |||||... |      . | ..     | ..|. ||  |.| .|  |..
rlriddyhppal...eqvvefvrvveeaeeknea.vsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvr
Y_phosphatase3 Tyrosine phosphatase family 315-380 5.2e-07 24.8 Pfam-A 92-154 (164) alignment 
Range on Protein: 315-380
Range on HMM: 92-154/164.0
QSWPDMGVPQYPTTLISYTQTVKHVHERITANTkGstPMLVHCSAGVGRTGTFISLYCMLAQVIEE
..  .. .  | . | ........| | . ... |  |.|.||.||  ||| .. |   |. | ||
eeaeeamaeayreiledekkayrkvlealaeee.g..pvlfHCtaGKDRTGvvaalllsllgvdee
subfamily_PTEN_pd Subfamily PTEN 333-406 8.3e-07 24.2 In-house 99-171 (184) alignment 
Range on Protein: 333-406
Range on HMM: 99-171/184.0
TQTVKHVHERITANTKgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRvDIFGFIQKMRKDRPNMVQTADQ--Y
.. |..... . ...|    . ||| || ||||. |. | . .. .|... ..  . ...|    . |.   |  |
eeivediekwleedkk..nvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqrRY
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 521-696 8.3e-07 22.7 In-house 94-274 (302) alignment 
Range on Protein: 521-696
Range on HMM: 94-274/302.0
LATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK--DSVQFGPLKVSIISAETI------RSDYVMRKFEIKGPKKG---TLTVKQF
    .|   |.   | .. ...  ..| | .. . ..| ||.|. .|  . ..||   |  .| .|       . .... . |||  ||      ||. .
kkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdil

QLMGWDgNQKRPASLAPILHLVDaVSECVRTSqasgpIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESV
.  .|  .   |.   . |...    |. ...     ...|| .|.||.| . ||    .   ..   |. . |. .|. |   . . 
afsawp.dhGapkeaytaldilk.fcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqde
PTEN_1 289-400 1e-06 23.7 In-house 65-179 (196) alignment 
Range on Protein: 289-400
Range on HMM: 65-179/196.0
SDHVHRVLDVKQVSGG-------ETRSVHQ--FHYQSWPDMGVPqyptTLISYTQTVKHVHERITANTKgSTPMLVHCSAGVGRTGTFISLYCMLAQVie
.|... |...   .         |..  ..  ..  ...| |.|    .| .    .| ..| . .. .     |||| ||.||.|| .  | | ..   
edgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap....slselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgk..

ESRVDIFGFIQKMR-KDRPNMV
 .  . . .....| . .||. 
ltadeAlelvrekRppgapnsp
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 175-276 1.3e-06 20.2 In-house 28-117 (275) alignment 
Range on Protein: 175-276
Range on HMM: 28-117/275.0
ENKAKNRFKNIVAFDhsrvvlETLKDDPHSDYYNANYIRDDKGKktFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGkdrcTVYWPKEMGKSKT
 |  |||| |...||      | |  . .  . .|| .|   |.  |. .|||| ..  |. .|.|  || .|| .    | |      . |||     .
rngeknrftnvtcfd......eildrenqeffvhantfrtpygn..flisqapndstnadhlhllwiynvqtvvclvlpeeag....gyfvpkegetfts

FG
| 
fq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 468-549 2.3e-06 21.4 In-house 30-116 (347) alignment 
Range on Protein: 468-549
Range on HMM: 30-116/347.0
KAAGLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTD----YINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML
 ..    ...|||  .|  ... |  |   | . . .|    ||||| ..    .  .. || |||.|  |.|.||   .   .| .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 633-710 3.5e-06 20.6 In-house 255-344 (349) alignment 
Range on Protein: 633-710
Range on HMM: 255-344/349.0
VSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAE--KMITDSSVD----------IFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
 ..    .. . ....||  | ||.||.  . .  .  .. .. |.           |. .|  ||  | ||.. . |. ..|| . .|.
farlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
PTEN_1 622-698 4.7e-06 21.5 In-house 109-183 (196) alignment 
Range on Protein: 622-698
Range on HMM: 109-183/196.0
SLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMitDSSVDIFQSVKRLR-ANRPSmIESVDQ
||. ... .. . |...  .  . .. ||  |.||||. .| |  . .   ..  . .. |.. | ...|  . |  .
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk..ltadeAlelvrekRppgapn.spsqer
subfamily_PTPDC1_pd Subfamily PTPDC1 621-704 5.4e-06 21.0 In-house 96-170 (182) alignment 
Range on Protein: 621-704
Range on HMM: 96-170/182.0
ASLAPILHLVDAVSECVRtsqaSGPIVLHCINGIGRSGVFAAIYsaaekMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
|||  || .|  |. ...     | . .||  | || ||  | |     ..  ....  ...| .|..||. |.. .|  .. |
asleriLdivkvvafalq....egkvavhChaGlGrtGvliacy.....lvyakrltaekaiklvrskrpksiqtreqvelvke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 175-267 5.7e-06 19.3 In-house 25-85 (169) alignment 
Range on Protein: 175-267
Range on HMM: 25-85/169.0
ENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNAnyirddkgkktfiaaqapntasindfwRLIWQENVcSVVMVTnileGGKDRCTVYWPK
 |..|||    .|  | || |. . .|  ||| ||                           |.||. |  ||..|     |. |    .||.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetna.svivvl....Gdtddknnfwpe
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 175-267 7e-06 19.1 In-house 26-86 (169) alignment 
Range on Protein: 175-267
Range on HMM: 26-86/169.0
ENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNAnyirddkgkktfiaaqapntasindfwRLIWQENVcSVVMVTnileGGKDRCTVYWPK
 |..|||    .|  | || |. . .|  ||| ||                           |.||. |  ||..|     |. |    .||.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetna.svivvl....gdtddknnfwpe
PTPlike_phytase Inositol hexakisphosphate 338-374 8.2e-06 20.5 Pfam-A 113-148 (149) alignment 
Range on Protein: 338-374
Range on HMM: 113-148/149.0
HVHERITANtKGSTPMLVHCSAGVGRTGTFISLYCML
 . . |  . . .| ....|.|| ||| |.. ....|
afvrliksl.prdtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 338-374 8.2e-06 20.5 In-house 113-148 (149) alignment 
Range on Protein: 338-374
Range on HMM: 113-148/149.0
HVHERITANtKGSTPMLVHCSAGVGRTGTFISLYCML
 . . |  . . .| ....|.|| ||| |.. ....|
afvrliksl.prdtalvfnCqaGrgRTTtamviadLl