Gene SpurPTP-sf3-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP102_AA protein Get Run
SpurP102_AA_2-265 phosphatase_domain Get Run
SpurP102_AA_277-540 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-402 2.2e-133 440.9 In-house 36-418 (564) alignment 
Range on Protein: 1-402
Range on HMM: 36-418/564.0
QQSPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKD
||..||.|.|. ||.|||. ||.|||||||||.||.||. ||| ||...    || ..   .  . .|   ..  ||||.|..|..||||.|.| | ||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid..gyrkrk..ayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkv

RCRQYWPKNpRsVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtKhqrghtelsQSLFPLLL
.| .|||.. .  | .|..   | | |...| ..||...|||.|.|.|.. |.|. |||| ||||. |.|... ..|.... .         .   |.. 
kchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.........pdagPivV

SpvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFK
   |||||||||||| .  ||. .|||. |||.......|..|  ||||.|||||...|.||   .|.||........... |.. .. |. .....||.
h..CSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFq

NLHTLTPTPsANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELD
.| | .... ...| ..  . |.|||||..||.||..|  |    .   .||||||.|.....|  |.|||.|| |||||.||. .. .  .||||..|.
rLatakeie.leefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwrmvweeevkiivmltkle

EE
|.
ek
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-300 8.8e-91 299.4 In-house 41-324 (325) alignment 
Range on Protein: 6-300
Range on HMM: 41-324/325.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRiqniCLFFVSSAPNTASLTAFWRMI--WQenvATIVMVTNLIEAGKDRCR
.|| | .|| ||||.|..|.|.||||||  . ||.|||.||.||   . .      |. . ||.||..  .||..  |.   ...|.|.| .. ||||| 
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk....dvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrca

QYWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrgHTElSQSLFPLLLSpv
.||||.      .| . . |  .|..||.. | | ||. .  | |.. |... ||.||||... .||||....||. . .    ... ...  |.|.   
vywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavserv...tan.tkastpilvh..

CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFK
|||||||||.||.|| .|. . || ||||| |. |.|..| .||.| .|||..|.|| |.|.||.|..||| |  |. .|.  | .|.| ||. ||.
csaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4-344 1.5e-86 285.6 In-house 34-356 (515) alignment 
Range on Protein: 4-344
Range on HMM: 34-356/515.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsiyRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
|  || .| | .|||..||. || .|| || .. .|||||||| |.      ..|   .  | .|| ||.  |||...||||.||.|||.| |  | .| 
pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip....sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcg

QYWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESeeKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelSqslFPLLLSpv
.|||. |     .| ... |. .|  .. | |.| | | .    ||. |.|.  ||| |||.  ..|. .   ||  | .        .   .||..   
kyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqy.......t...hpliih..

CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFKNLH
||||||||| .| . ...  .|.   ||.| |. ..|..| ..|||.||| |.|.|.||  |  .| ||| .| .... || .     ....  ||. |.
csaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk

TLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACP
.|.| | |.  ||||.  |. |||. . |||.|||  | .|
slcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildsp
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-271 6.5e-81 266.8 In-house 45-297 (298) alignment 
Range on Protein: 2-271
Range on HMM: 45-297/298.0
QSPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDR
.  .|||.|..|| |||. .|||.|.|||||||.|.| .||| || .|.   |. .|   | .. || |.... ||||...|...||||.||| | .| .
eeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh..aykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CRQYWPKNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQhhTKHQRGHTelsqslfPLLLs
. .|||..    |  |.... ||. |.|.| |||.|.|.||..|..|...| |. |||| ||||..|... . . |..  ...| |..       |... 
yhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra..sqqqagnk.......pviv.

pVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEI
  |||||||.|||| .. .|. .|.|  ||.|  .  .|..|...|||.|||.|.|.| ||.  |...||
.qCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 8-302 3.1e-80 264.6 In-house 41-318 (318) alignment 
Range on Protein: 8-302
Range on HMM: 41-318/318.0
ASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWP
. .. || |||. ||.||||.|| |....|.. ||| ||||.    || ..   .  . || .  .. ||||.|. | |.|||.|.. |.||... .|||
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidG..yrrkka..yiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

KNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfPLLLspVCSAG
..    . .|.    | |  ..||...|.. |...|.||.|.. |||| |||| ||||  ..|...  .|.. ..|...|         |..    ||||
sk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag.........pivv..hCsaG

VGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFKNL
|||||.|| .  .|. .|.|. ||.| .....||.|  ||||..||.|.|..|||   ||.||.  |..|...  |..... . ......||..|
vGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
0050432 (Phosphotyrosine protein) phosphatases II 4-270 1.3e-79 263.1 In-house 59-305 (308) alignment 
Range on Protein: 4-270
Range on HMM: 59-305/308.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLekvdgDPHSDYFNANYLSVSIyrIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
...||....||.|||...|..||||||.|     |..||| ||.| .. .    . . | .  .|   ..  ||||.|..|| .|||.|.|.| |.  | 
eysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgys..sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekca

QYWPKNPR-SVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqRGhtelsqslfplllSP
|||| ..  .... |.|.. ||..|...|..||||........| ||. ..||..|||.|||.. . |..| . |....    .|             .|
qYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pg.............gp

---VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTE
    ||||||||||||.|. .|.....||.||.|. . |.|| |  ||||.|||.||| |||| ... .| 
ivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0046845 (Phosphotyrosine protein) phosphatases II 4-271 6.6e-79 260.5 In-house 19-281 (284) alignment 
Range on Protein: 4-271
Range on HMM: 19-281/284.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGD-PHSDYFNANYLSVS-IYRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDR
...|| ...|. |||...|..||||||.|  .||| ..|||.||.|...  .  . . . | . ..|   ..  ||||.|..|| .|||.|.|.| |.  
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

CRQYWPKNpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKE-SEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKhqrghtelsqSLFPLLL
| |||| .  .| ..|||.  ||..|...|..|||| ..... ..| ||. ..||.||||.|||.. . |..| ..|......          .  .   
caqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen..........lpgggpi

SPVCSAGVGRTGTFICLYNMLDMMKEEG---RVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEI
   ||||||||||||.|. .|.....||   .||... ....|| |  |||| |||.|.|.|||| .....| .
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0051299 (Phosphotyrosine protein) phosphatases II 4-264 1.9e-78 259.1 In-house 40-286 (288) alignment 
Range on Protein: 4-264
Range on HMM: 40-286/288.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLsvSIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
.. .|....|..|||...|..||||||.|  .||...||| ||.|.  ..|....   | .  .|   ..  ||||.|..|| .|||.|.|.| |.  | 
tlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekca

QYWPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKK----ESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTkhqrghtelsqslfpL-
||||   ..... ||..  ||..|...| .||||.|...     ..|.||. ..||..|||.|||.. . |..|   |....                  
qYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...............sg

--LLSPVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
       ||||||||||||.|. .|.....||.||..... ..|| |  |||| |||.|.| |||| .
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4-300 2.8e-78 258.2 In-house 39-319 (319) alignment 
Range on Protein: 4-300
Range on HMM: 39-319/319.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
 .. ||||.||.|||..||.|||..|||| ..|| . ||| ||...    |. ..   |    ||    .  ||||.|.|.. ..||.|.| | .| ...
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg..yqere..kfiatqaPlentiedfWrmvWeeessivvmltklveklkvklk

QYWPKNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEE-KRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfPLLLsp
.|||..   .|. | . . |.| |. .| |.| | ..|| ||   |......|..||| .|||. |.|. .   ... . |.| |         |.    
kywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg.........Pivv..

VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFK
 |||||||||||| |  ||. .|||| .|.||..|..|  |  |||..|||.|.|.||||.  .|.||| | ..|... .|   .. | .. .. ||.
hCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
subfamily_PTPRA_pd Subfamily PTPRA 2-299 2.9e-78 258.0 In-house 47-330 (330) alignment 
Range on Protein: 2-299
Range on HMM: 47-330/330.0
QSPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDR
|.  |.||||.|| |||. ||. ||.|||.| ...| ..||| || ..    |. ..   |  .  | . ..  ||||||. . |||||.|.| |  ...
qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid..Gykekdk..fiaaqGPkeetvedfwrmiweqksativmltelkerkeek

CRQYWPKNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVK----KKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrGhtelsQslfP
| ||||..   .   |.  . . ...   |  || ..|.    ... ...| . |.|. ||||.|||     ....   ||. . ..  .     .   |
caqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs..a.....g...p

LLLspVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHV
. .   |||||||||||| | ..|...| |..||.| |....| .| .||||.||| |.|..||| || | ||. || . .....|.   . |.|  .  
ivv..hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkiglee

EF
||
ef
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 303-539 5.6e-78 257.3 In-house 29-273 (325) alignment 
Range on Protein: 303-539
Range on HMM: 29-273/325.0
HTLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE-
  |.|.  . ...      |..||||.....|...|. |   .  .|.||||||.|....|||||||.|.||..|..|||||..||.|.|.|.|||||. 
fgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlg

-ETCVQYWPEE--GSIALETLEVTALDSESTMNFVKRRFTVTSD-SGESMTVEQFEMLGWG-M-SHNKPDSPVSLLGLIEAVQGSIKT-ATCKGPAIVHC
 . | .|||.|   |  . .|||     |   ..|.|.. |     ||...|.||.. .|  |  ...| . .|.| |..||.  ... . . .| .|||
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

VNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
..|.||.||| .|.|...|. ..  .|||. ||.||  ||.||||
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvet
0036941 (Phosphotyrosine protein) phosphatases II 4-276 3.9e-77 254.8 In-house 30-289 (297) alignment 
Range on Protein: 4-276
Range on HMM: 30-289/297.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLekvdGDPHSDYFNANYLsvSIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
...||....|..|||...|..|||.||.|    .|..|||.||.|.  ..|....   | .  .|   ..  ||||.|..|| .|||.|.|.| |.  | 
slsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv..dgydlkrk..fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPKNPRSVEVMGDFSLFLLEVEQ--FSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsqsL--FPLL
|||| . ... . |||...||.||.  ..| ..||| |......|.||. ..||..|||.||||....|..| . |.... .               | |
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll..........psggpvl

LspVCSAGVGRTGTFICLYNMLDMMK---EEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKF
    |||||||.||||... ||....   .||.|||.... |.|| |  .||| |||.||| |||| .....| .|..|.
V..HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_PTPRK_pd Subfamily PTPRK 5-300 5e-77 253.8 In-house 35-313 (314) alignment 
Range on Protein: 5-300
Range on HMM: 35-313/314.0
WEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLsvSIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQ
|..| |..|. |||. .|.|||.|||.|  .||||.||| ||...    |.  .   | |   |    .. |||....|| |.|||.|.|.| |. .| .
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali..dsykrpa..afivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClk

YWPKNPRSvevMGDFSLFLLEVEQFSDHIVRTLIVKK--KESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKhqrghtelsqSLFPLLLSp
|||.. .     ||. . |.|.|  .. .||.. |.|  .  ||.|.. |...|.||| .|| . |.|...   ||... .          .  ....  
yWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..........eaGrivvh.

vCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFK
 |||| ||||||| .  .|||...|| ||.|  . ..|.... ||.|.|||.|.|...||  | |.| ||||.|.       | .. |. .... ||.
.CsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
0040438 (Phosphotyrosine protein) phosphatases II 3-299 2.3e-76 252.4 In-house 33-311 (317) alignment 
Range on Protein: 3-299
Range on HMM: 33-311/317.0
SPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRIQniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRC
....||....||.|||...|. ||||||.|  ..||..||| ||.| ..  .. .    | . ..|   ..  ||||.|...| .|||.|.| | |.  |
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk....fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

RQYWPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqrghtelsqsL---FPLL
 ||||   ... . |||.  ||..|. .. ..||| |......|.||. ..||..|||.|||.. ..|..| . |...                   |.|
aqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.............edpggpvl

LspVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEF
    ||||||||||||..| ||.....||.||... . ..|| | ..||| |||.||| |||| .. . | .|.|..  |.. |..   ...  ... |.
V..HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3-285 2.5e-76 251.7 In-house 36-304 (305) alignment 
Range on Protein: 3-285
Range on HMM: 36-304/305.0
SPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRC
.. .| .||.|| |||...|. .|..|. | . . ...||| ||.|.    |. ..   . |. .|    .. |||.|..| | ||||.|.|.| |||.|
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd..gykrkkk..yivaqgPlkntvadfWrliveekvstivmltklveggkdkC

RQYWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKK-KESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfPLLLs
|||||.. . .. .|.||. | . ...||.| | | . . .|..|.||..||.  .||| |||.. |.|.|. . |.... | .           |||  
rqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv.........pllV.

pVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHR
 .|||||||||.||..  .|. .|.|. ||.|  . ..|..|.|||||..|| ||..|| |   .|.|.| .| .| ... |..
.hCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklkk
subfamily_PTPRB_pd Subfamily PTPRB 5-268 5.6e-76 250.4 In-house 43-289 (293) alignment 
Range on Protein: 5-268
Range on HMM: 43-289/293.0
WEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQ
 ..|....|. |||..||..|||||| |........||| ||||..   |. ..   | ..  |   ..  ||||.|.... .|||.|.|.| || .| .
vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipg..ynspr..efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCee

YWPKNPRSVeVMGDFSLFLLEVEQFSDHIVRTLIVKKkeSEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHtelsqslfPLLLSpvC
|||.. ..| . || .. |.. |. .|...|.| ..|  ..|.|.. |||..|||| ||||  .||..|. ||.....|... .        |..    |
YWPadeepv.lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr........Pivvh..C

SAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGK
|||||||||||.| ..|. ..||  ||||......||.|  .|||..||||.....|..  ...
saGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0047943 (Phosphotyrosine protein) phosphatases II 4-263 1.5e-75 249.5 In-house 29-271 (273) alignment 
Range on Protein: 4-263
Range on HMM: 29-271/273.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLekvdGDPHSDYFNANYLsvSIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
...||....|| |||...|..||||||.|    ||..||| ||.|.  . |....   | .  .|   ..  ||||.|..|| .|||.|.|.| |.  | 
tysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv..dgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

QYWPKNPRS-VEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfplllSP
|||| .  . ... |.|.  ||..|...|..||||........|.||. ..||..|||.|||.... |..| . |.... .  ..             .|
qYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.............gp

---VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
    ||||||||||||.|. .||....||.||... . ..|. |  |||| |||.|||.|||| 
vvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 6-264 4.2e-75 247.5 In-house 40-279 (288) alignment 
Range on Protein: 6-264
Range on HMM: 40-279/288.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRIQniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
..... .|..|||.|||..||. || |.|..  . .|| ||.|. ..  . .    .  . .|.....  ||........ ||||.|.|.| || .| .|
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkk....yiatqgPladtvndfWelvyenktstivmltelveggktkCeeY

WPKNPRSvEVMGDFSLFLLEVEQFSDHIVRTLIVKKKEseEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsqsLFPLLLspVCS
||.. .  .  |.. . |.|...  |...|.|...||.  ....| ||.||.|||.||||  . |. . ..||. ...           . |..   .||
WPdadkp.knyGsvtvtlveskeledfvlrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvkvanqad..........tgpiiv..hCs

AGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
|||||||||| | ...|...||  .|......|.|..|  .|||..||.|.|..||.. 
aGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-301 1.2e-74 246.0 In-house 35-314 (315) alignment 
Range on Protein: 4-301
Range on HMM: 35-314/315.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsiyRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
.  || .. | .|||..||. .|..||.|| .| .|.|||.|| |.      ...   .. | .|. ||.  ||||..||.|.||||||.. |  | .||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik....svdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYWPK-NPRSVEvMGDFSLFLLEVEQFSDHIVRTLIVKKkeSEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQrghtelsqslFPLLLSp
||||. .  ||| .| ... ||..|. .| ..| |...|  |||.||. |...  ||| ||..  ..|. .   ||  . |..          |.||.  
qywPdrkadsve.fGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkke..........fsllvh.

vCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFKN
 ||||||||| .| . .... .|..  ||.| |. ..|..|...|||.|.| |.|.|.||  |  .| |.| .| .... || . . . ....  ||..
.csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefet
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 6-263 1.2e-74 245.6 In-house 2-241 (250) alignment 
Range on Protein: 6-263
Range on HMM: 2-241/250.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRiqniCLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDrCRQY
.|| | .|| |||. .|||.|.|||||||..|| .||| || .| .   |     .| .. .| .|..  ||||...|...||||.||| | .|  . ||
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder....kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPKNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfPLLLSpvCS
|| .    |  ||  . ||. |.|.| ..|.|.. |.. ...|...|.|...||| ||||..|. . . . |.. . . . .         |...   ||
wPve..kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna.........Pvivq..Cs

AGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
|||||.|.|| .. .|. .|.|  ||.| .| ..|..|...|...|||.|.|...|. 
aGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
0051299 (Phosphotyrosine protein) phosphatases II 267-540 2.4e-73 242.4 In-house 1-272 (288) alignment 
Range on Protein: 267-540
Range on HMM: 1-272/288.0
GKTEIPVSKFREKMDTLHransVTKKANIHVEFKNLHTLTPTpsaNSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDV
|.|||.|..... . .|.     . ..... ||. |  |.|.   .......   |..|||..||||....| .|  .......||||||.......|  
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTS-----DSGESMTVEQFEMLGWG
|.||| |||||||| ||. ......|||||..|.|   |.| ||||..||. .. . || |. |.  ....| ..||       .||| || .| ...| 
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

mSHNKPDSPVSLLGLIEAVQGSIKtaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
  |. |||| .|| ....|. ...   ..|| .||| .|.||.|.|.||. ..| |.| ...|...||||||. ||.||.|.
.dhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-283 3.3e-73 241.4 In-house 38-298 (315) alignment 
Range on Protein: 2-283
Range on HMM: 38-298/315.0
QSPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDR
  | .|| | .|| |||. ||||||.||| |  .. |||||| |||..    |  ..   .  . .||.||.  |||....|....|||.|||.|  | .
lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidG..ynkkr..ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrk

CRQYWPKNprsVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKesEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQrghtelsqslFPLLLs
. .||| .     . | ... . . |....  |||| |  .  .. |..||.|| ||||||||.| ..|. .  |||||||.             .... 
aekywpdk...kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..........gaivv.

pVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTL
  ||||||||||||.|  .|| .. |  .|.. || ..|.|||||||. ||| |.|.|||| .. | | |    . .. |.|
.hcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl
0050432 (Phosphotyrosine protein) phosphatases II 280-540 7.2e-72 237.6 In-house 29-285 (308) alignment 
Range on Protein: 280-540
Range on HMM: 29-285/308.0
MDTLHRANSVTKKANIHVEFKNLHTLTPtpsANSFRSGRASINRKKNRFPDILPLERNRPYLacpgSiGSTDYINASFLNTF--QKKDVFLATQSPLPNT
.| |.. .. . . ... ||. |  ..|    .......   |..|||..||||....| .|    . ...||||||. ...   ..  |.|||.|||||
ldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpnt

VEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEE---GSIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSL
||| ||. ......|||||..|.|   |.| ||||.|   ||.  . . || |. |.  ....| ...|  ..||| || .| ...|   |. |.|| .|
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeil

LGLIEAVQGSIktatCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
| ..|.|. |.     .|| .||| .|.||.|.|.||. ..| |.|....|.|.|||.||. ||.||.|.
ldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0043336 (Phosphotyrosine protein) phosphatases II 4-262 1.2e-71 236.7 In-house 36-275 (278) alignment 
Range on Protein: 4-262
Range on HMM: 36-275/278.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRIQniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
....| ...||.|||...|..||||||.|. ..||..||| ||.|...  .  .    | ....|.. ..  ||||.|...| ||||.|.| | |.  | 
tysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk....fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkca

QYWPknpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqrghtelsqslfplllsP-
||||   ..... |||.  ||..|...| .|||| |... . |.||...||||.|||.||||  ..|..|  .|...                     . 
qYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal....................ed

-------VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
        ||||||||||||.|| .|.... ||.||... ....|| | ..||| .||.|||.||||
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 4-264 1.5e-71 237.0 In-house 46-304 (307) alignment 
Range on Protein: 4-264
Range on HMM: 46-304/307.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGD-PHSDYFNANYLSVSIYRIQNIC----LFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAG
....|....||.|||...|..|||.||.|  .||. ..|||.||.|  | .... ...     | .  .|   ..  ||||.|...| .|||.|.|.| |
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelg

KDRCRQYWPKNpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKK-ESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfp
.  | |||| . ... . |.|   ||..|. .. .|||| |. . ...| ||. ..||..|||.|||..  .|..| . |.... ....|          
rekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg..........

lllSP---VCSAGVGRTGTFICLYNMLDMMKEEGR---VDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
   .|    ||||||||||||..| ||.....||    ||... ....|| | ..||. |||.|||.|||| .
...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 3-269 2.2e-71 236.1 In-house 46-294 (297) alignment 
Range on Protein: 3-269
Range on HMM: 46-294/297.0
SPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDG-DPHSDYFNANYLsvSIYRI-QNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKd
 ....| ...||.|||...|..||||||.|  .|| |..||| ||.|.  . |.. ..   | ....|.. ..  ||||.|...| .|||.|.|.| |. 
pdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltr..kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.

RCRQYWPKNPRsveVMGDFSLFLLEVEQFSDHIVRTLIVKKkeSEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsQ-SlFPLL
 | |||| .     . |||.  ||.||. .. .|||| |..  ..| ||. ...|..|||.|||.. ..|..| . |.... .         . .  | |
kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael........pkg.gpvl

LspVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKT
    ||||||||||||..| ||.....||.||... ....|| | ..||| .||.|||.|||| .. ..|
V..HCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
DSPc_SM00195 4-263 2.3e-71 235.6 In-house 17-261 (263) alignment 
Range on Protein: 4-263
Range on HMM: 17-261/263.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRIQNIClffvSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
. . | |.||| |||..||. |||.|| |.| .....||| ||||.... .. . |.      .|    .  ||||.|.|.| .|||.|.  | || .| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIa....tQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

QYWPKNPRSVEVMGDFSLFLLEVEQFS-DHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsqsLFPLLLsp
.|||..  . |..|..|. | |||. . . |.||| ..|.. ||.|.. ||.| .||| |||.  . ....  .||... .             |..   
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........sgpivV..

VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
.|||||||||||...  .|. ..|| .||||. ....|..|..||||.|||.|.|.|.||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 4-263 2.3e-71 235.6 In-house 17-261 (263) alignment 
Range on Protein: 4-263
Range on HMM: 17-261/263.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRIQNIClffvSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
. . | |.||| |||..||. |||.|| |.| .....||| ||||.... .. . |.      .|    .  ||||.|.|.| .|||.|.  | || .| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIa....tQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

QYWPKNPRSVEVMGDFSLFLLEVEQFS-DHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsqsLFPLLLsp
.|||..  . |..|..|. | |||. . . |.||| ..|.. ||.|.. ||.| .||| |||.  . ....  .||... .             |..   
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........sgpivV..

VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
.|||||||||||...  .|. ..|| .||||. ....|..|..||||.|||.|.|.|.||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0040439 (Phosphotyrosine protein) phosphatases II 4-264 3.2e-70 231.9 In-house 2-246 (249) alignment 
Range on Protein: 4-264
Range on HMM: 2-246/249.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRIQniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
...||....||.|||...|..||||||.|. ..| ..||| ||.|.... .  .    | . ..| . .. .||||.|.... .|||.|.| | |.  | 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr....fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekca

QYWPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsqsL--FPLLLs
||||   ... ..|||.  ||.||...| .|||| .....  |.||. ...|..|||.|||..  .|..| . |......               |.|  
qywpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel..........pkggpvlV.

pVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
  ||||||||||||..| ||.....|..||... ....|. | ..||. |||.|||.|||| .
.HCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 6-262 6.1e-70 230.7 In-house 2-241 (245) alignment 
Range on Protein: 6-262
Range on HMM: 2-241/245.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLsvSIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
.||....||.|||...|..|||.||.|  ..||..||| ||.|   . ||| .   |.....| . .. .||||.|.... ||||.|.. | |.  | ||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKhqrghtelsQSLFPLLLspVCS
||   ... . |||.  ||..|...| .|||| |... . |.|....||||.|||.|||..  .|..| . |...  .          |  |.|    ||
wpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpvlV..HCs

AGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||||||||||..| ||.....|..|.... . ..|. | ..||| .||.||| ||||
aGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 2-308 1.2e-69 230.0 In-house 36-330 (563) alignment 
Range on Protein: 2-308
Range on HMM: 36-330/563.0
QSPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHS-DYFNANYLSvsIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKD
. . | ..|..|| |||  ||.|||.||| |... |  .. || ||||.    |. ..   | ..  | .  .  ||||||..|||.|||.||| | |. 
dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid..Gyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrr

RCRQYWPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKK---KES---EEKRTIVQYHYLSWPDMGVPEYYTTLISFtdtVKQHhtkhqrgHTELSQS
 | .||||    .| .| ... | | |...   ||||..|.   |.    ...... |||| .|||.||||. .  ..|   ||..        .   . 
kcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif...vkks.......saankae

LFPLLLSpvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSvTKKAN
  |..    ||||||||||.| |  .|  ...|  |..| |. ..| .|  .|||.||||||..||||. .|..||.  .. .|  ..    .    |  
aGPivvH..csaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyleq.qykni

IHVEFKNLHTLTPT
|... |..|  .  
iqfqpkdihiasam
0047943 (Phosphotyrosine protein) phosphatases II 286-539 2e-69 229.5 In-house 5-257 (273) alignment 
Range on Protein: 286-539
Range on HMM: 5-257/273.0
ANSVTKKANIHVEFKNLHTLTPtpsANSFRSGRASINRKKNRFPDILPLERNRPYLacpgSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLA
 .. . .. .. ||. |  |.|     ... ..   |..|||..||||....| .|    . |..||||||.......|  |.||| |||||||| ||. 
lekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

FDWKCPVIVMLNELDE---ETCVQYWPEEG---SIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQ
......|||||.||.|   |.| ||||.||   |.  . . || |. |.  ....| ...|. ..||| || .| ..||   |. |.|. ||| .||.|.
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielvr

GSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
  ....  .|| .|||..|.||.|.|.||. ... |.| ...|...|||.||| ||.||.|
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 7-276 8.1e-69 227.0 In-house 45-296 (297) alignment 
Range on Protein: 7-276
Range on HMM: 45-296/297.0
VASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRiqniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKdRCRQYW
|| |  | .|.|..||. || ||| |. |. || |||.|| .. .  .|      .  .  |. |..  ||.|...|.|.||||.... |  | .|..||
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhr......littqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PKNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPE--YYTTLISFTDTVKQHHTKHqrghtelSQSlfPLLLSpvC
...  .|  .|| |. || |.. .  | |.| |.| ..  .| . ||....|||  |..    ..|. . . |.... ..       ...  |||.   |
sdk..gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqn.......aeg..Pllvh..c

SAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKF
.||||||| .. . ...  .|.|  |||| ...|.|..| ..||||||| |.|.|.||. || .|.|..| |
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
0046845 (Phosphotyrosine protein) phosphatases II 295-540 1.4e-68 226.7 In-house 2-260 (284) alignment 
Range on Protein: 295-540
Range on HMM: 2-260/284.0
IHVEFKNLHTLTPTPSaNSFRSGRASINRKKNRFPDILPLERNRPYLACPGS-IGSTDYINASFLNTF-----QKKDVFLATQSPLPNTVEDLWRLAFDW
.. ||. |  ||....  |.. ...  |..|||..||||....| .|  ... ....||||||.....      .|  |.||| |||||||| ||. ...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KCPVIVMLNELDEE---TCVQYWPEEG-SIALETLEVTALDSESTMNFVKRRFTVTSD--SGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIK
...|||||.||.|     | ||||.|| .. .. . || |. |   ....|....|    .|||.|| .| ...|   |. |.|| .|| ....|. ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrelle

TATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDN---TIDIFQAVKRLRSSRPNMVETL
   ..|| .||| .|.||.|.|.||. ..| |.|..   ..|...||||||. ||.||.||
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 267-539 5.4e-68 224.4 In-house 1-275 (298) alignment 
Range on Protein: 267-539
Range on HMM: 1-275/298.0
GKTEIPVSKFREKMDTLHRANSVTKKANIHVEFKNLHTLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDV
|.||| ........  |   .  .| .. . ||..|.. . .  ... . .|.. |.||||..||..|.  |  |    .   .||||||||....... 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDS-GESMTVEQFEMLGWGmSHN
|.||| ||..|||| ||.  . .  .||||..| |    .. .|||.||.   ....|. | .|.  ....|...|.. .  .. .| |...  |  .. 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWp.dkg

KPDSPVSLLGLIEAVQGsIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 |    |.|.|.. |.   .. . . | ||.| .|.|||| |.|. ||.|...|....|.||.||.|| .||..|.|
vpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt
subfamily_Ptp69D_pd Subfamily Ptp69D 6-283 2.3e-67 222.3 In-house 41-305 (307) alignment 
Range on Protein: 6-283
Range on HMM: 41-305/307.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYriQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
.|. |. |. |||. .|.|.|. ||.|.|. |. .||| ||...    |  ..   | .. .|  | .  |||||.. .| .|||..|| |  ...| .|
kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikg..y..kekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WPKNprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKE-----SEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqrghtelsqsLFPLLL
||..       ||    | . |. ||.| |.| | ||.      |..| .|||||..|.|. |||  ..|. . . |.... ..            |...
Wpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..........rsPivv

SpvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTL
   |||||||.|.|..|  .|. .|.| .|||| .. ..|..|  .||  |||.||| |||.    |.|.. | .. .....|
h..CsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-263 4.4e-67 221.1 In-house 35-275 (281) alignment 
Range on Protein: 7-263
Range on HMM: 35-275/281.0
VASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYriQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYW
 . ...|. |||..||.|||..||.... . . ..|| |||...   |  ..   . .. .|  |||.|||.|.|...| .|||||. ||||| .| .||
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg..y..kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PkNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVkKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRghtelsqslFPLLLSpvCSA
| ...|   .||. .  .. |. . .| |.. . ..|| |.|...| .|..||| |||.  . |..| . |.. ..|..           ||..   |||
P.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.........aplvih..Csa

GVGRTGTFICLYNMLDMMKE-EGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
|||||||.| |  ... ... . ..|.   . ..|..|  ||||  || |.| |.|..
GvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_PTPN6_pd Subfamily PTPN6 8-267 1.2e-66 219.8 In-house 49-299 (306) alignment 
Range on Protein: 8-267
Range on HMM: 49-299/306.0
ASKEKNKPKNRFRNIIAYDHSRVVLEkVDGDPHSDYFNANYLSVSIYRIQniCLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWP
..| .|| |||..||. .||.||.|.  .. | ||| ||||.. ..   .  . .  ..   .. .. ||||.||||   |||.|. .| ||..| .|||
gakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP

KNPRSVEvMGDFSLFLLEVEQFSDHIVRTLIVK-KKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQrghtelSQSLFPLLLSpvCSA
.. .. | .|. |.  .. .. .| |.|.| |. ||...|.|...|||. |||| |||.   ....| ..|.... . .      ...  |..    |||
deeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele......eaeagpivvh..Csa

GVGRTGTFICLYNMLDMMKEEG---RVDIFSFISKMRENRIKMVQTKEQYIFLYNALlEVYLSG
|.||||||| .  .|......|    .|| ... ..|| |  .|||..|| |.|.|. . |.  
GiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyiet
0036941 (Phosphotyrosine protein) phosphatases II 287-540 1.3e-66 220.3 In-house 7-263 (297) alignment 
Range on Protein: 287-540
Range on HMM: 7-263/297.0
NSVTKKANIHVEFKNLhtlTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLacPGsiGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAF
.. . .| .  ||. |   .|     |.. ..   |..|||..||||....| .|  ..  ...||||||...... |  |.||| |||||||| ||. .
ekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl..dd..egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

DWKCPVIVMLNELDE---ETCVQYWPEE--GSIALETLEVTALDSES--TMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQ
.....|||||.||.|   |.| ||||.|  .|.  . . || |. |.    ... | ..||  ..||| || .| ..||   |. |.|| ||| .||.|.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielvr

GSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLR---KDNTIDIFQAVKRLRSSRPNMVETL
  .| .. .|| .|||..|.||||.|.|.. ... |.   | ...||..||| ||. ||..|.||
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
subfamily_PTPN12_pd Subfamily PTPN12 4-264 1.6e-66 219.2 In-house 31-277 (290) alignment 
Range on Protein: 4-264
Range on HMM: 31-277/290.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSiyriQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
. |...||.|. |||...|. ||.|||.|.| .....||| |||..  .    .. . .  . .| .. |. ||||||. ||  .||. ...| || .|.
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv....egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

QYWPKNPRSVEVMGDFSLFLLEVEQFS-DHIVRTLIVKKKesEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTkhqrghtelsQSLFPLLLSp
.|||..  .   .|.|.. | | .... |...||| |...  .|.|.. |.|| .||| |||.  ..|......|.....          ..  ||..  
rYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..........sedaPlvvh.

vCSAGVGRTGTFICLYNMLDMMKEEGR---VDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
 |||||||||| | .  . ...|.|     .|.|. . ..|..|  .||||||| ..|.|..|. 
.CsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0040438 (Phosphotyrosine protein) phosphatases II 298-540 1.6e-66 220.1 In-house 19-262 (317) alignment 
Range on Protein: 298-540
Range on HMM: 19-262/317.0
EFKNLHTLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLN
 ... .   .. . .... ..   |..|||.|||||....| .|  .|.. ..||||||. .....|. |.|||.|||||||| ||. ..... |||||.
alleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

ELDEET---CVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKtaTCKGPAIVH
||.|     | ||||.....  ... || |. |   ... |...|.  ...|| || .| ..||   |. |.|| .|| ..|||. ...    .|| .||
eleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspdllldfleavreale..dpggpvlVH

CVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
|..|.||.|.|.|.. ..| |.| ...|...|||.||. ||..|.|.
CsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 10-281 4.3e-66 218.4 In-house 58-308 (319) alignment 
Range on Protein: 10-281
Range on HMM: 58-308/319.0
KEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYlsVSIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTnlieagKDRCRQYWPKN
 ..|| |||. ||.|.|...| ||...|   ||| || .  |. |. ..   .  .  |   .|  ||||||. |..|||..|      ||.| ||||..
ldqnkdknriinilafdknvvklerliGeefsdyinasf..vtGyqrkd..kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk

prSVEVMGDFSLFLLEVEQFSDHIVRTLIVKK-KESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHtelsqslfPLLLspVCSAGV
   |.  . | . .  ||. ....|| . . .  . ...| | |.|.| |||.|||.| . |. . . |.  ..| .  .        ....   |||||
..ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra........nivv..hcsaGv

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMD
||||..| |  .||.|||| .||.. |.  .|..| ..||   || |.| |||| .| |.... .  |   ..
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle
subfamily_PTPN9_pd Subfamily PTPN9 9-265 4.7e-66 217.8 In-house 38-291 (297) alignment 
Range on Protein: 9-265
Range on HMM: 38-291/297.0
SKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYlsVSIYRIQNICLFFVSSAPNTasLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPK
 .  |  |||. ... ||..||||.|||.|..||| |||.  |  |. ..  .    . ..|   . ||||.|...| .|||.| ..| |. .|.||||.
klranleknrytdvlcydetrvvlakvdedeasdyinanf..vdGykqkkafiatqGplkkt..vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

NPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHTEL--SQSLFPLLLSpVCSA
.  |..  ||.|.  .|||. .|. ||.| .|. . ||.|... . .||||| |||.  ..|. . ..|... ..  .  ..    .   | ..   |||
eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv.hcsa

GVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYL
|.||||||| |   |. ..|.| ||..  ....|. |  ..|| ||| | | |.||  |
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
0039614 (Phosphotyrosine protein) phosphatases II 278-539 6e-66 218.2 In-house 17-274 (297) alignment 
Range on Protein: 278-539
Range on HMM: 17-274/297.0
EKMDTLHRANSVTKKANIHVEFKNLHTLTPtpsaNsFRSGRASINRKKNRFPDILPLERNRPYLACPGSI-GSTDYINASFLNTFQK-KDVFLATQSPLP
. .| |.. .  ..|  .. ||..|  |.|    . .. ..   |..|||..||||....| .|  ...   ..||||||..... . .. |.||| |||
svldlllllekansktllllefeellslkp....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

NTVEDLWRLAFDWKCPVIVMLNELDEET--CVQYWPEEGSiALETLEVTALDSESTMNFVKRRFTVTSdSGESMTVEQFEMLGWGmSHNKPDSPVSLLGL
.|||| ||. ......|||||..|.|    |.|||||||.   ... || |. |   ... | ..||  .||| || .|  .||   |. |.|. .|| .
etvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwp.dhgvppslelllef

IEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
.|.|.  ....  .|| .|||..|.||.|.|.|.. ..| |.|  ..|...|||.||. ||..|.|
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt
Y_phosphatase Protein-tyrosine phosphatase 13-262 1.6e-65 216.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 13-262
Range on HMM: 1-235/235.0
NKPKNRFRNIIAYDHSRVVLekvDGDPH-SDYFNANYLsvSIYRiQnICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPR
|| |||...|..||..|| |   .|... ||| ||||.  . |. .    | .. .|   ..  ||||.|||.| .|||.|.| | |.  | ||||.. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv..kgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

SVEVMGDFSLFLL-EVE-QFSDHIVRTLIVKKKESE-EKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqrghtelSQSLFPLLLspVCSAGV
  .  ||... |  ... . .. ..|.| .|||..| |||.. |.|| .||| |||| .. |... . |....          ...  |..   .|||||
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvV..hCsaGv

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||||||..|  .|.....|. ||........|..|..|||. |||||||.|.||
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 13-262 1.6e-65 216.2 In-house 1-235 (235) alignment 
Range on Protein: 13-262
Range on HMM: 1-235/235.0
NKPKNRFRNIIAYDHSRVVLekvDGDPH-SDYFNANYLsvSIYRiQnICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPR
|| |||...|..||..|| |   .|... ||| ||||.  . |. .    | .. .|   ..  ||||.|||.| .|||.|.| | |.  | ||||.. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv..kgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

SVEVMGDFSLFLL-EVE-QFSDHIVRTLIVKKKESE-EKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqrghtelSQSLFPLLLspVCSAGV
  .  ||... |  ... . .. ..|.| .|||..| |||.. |.|| .||| |||| .. |... . |....          ...  |..   .|||||
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvV..hCsaGv

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||||||..|  .|.....|. ||........|..|..|||. |||||||.|.||
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 10-281 1.9e-65 216.2 In-house 22-272 (284) alignment 
Range on Protein: 10-281
Range on HMM: 22-272/284.0
KEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYlsVSIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTnlieagKDRCRQYWPKN
 ..|| |||. .|.|.|...| ||...|   ||| || .  .. |. ..   .  .  |   .|  ||||||. |..|||..|      ||.| ||||..
ldqnkdknrighilafdknvvklerliGeefsdyinasf..itGyqrkd..kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

prSVEVMGDFSLFLLEVEQFSDHIVRTLIVKK-KESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHtelsqslfPLLLspVCSAGV
   |.  . | . .  ||. ....|| . . .  . ...|.| |.|.| |||.|||.| . |. . . |.  ..|..  .        ....   |||||
..ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhra........nivv..hcsagv

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMD
||||..|.|  .||.|||| .||.. |. ..|..| ..||   || |.| |||| .| |.... .  |   ..
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle
0043336 (Phosphotyrosine protein) phosphatases II 290-539 4.3e-65 215.3 In-house 17-262 (278) alignment 
Range on Protein: 290-539
Range on HMM: 17-262/278.0
TKKANIHVEFKNLHTLTPtpsaNSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWK
. |. .. ||..|.. ..    .... ..   |..|||..||||....| .|   |.  ..||||||......... |.||| |||.|||| ||. ....
nlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

CPVIVMLNELDE---ETCVQYWPeEGSIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKtaT
...||||.||.|   ..|.|||| .||.  ... || |. |.  ... | ..||   .||| || ..  |||   |. |.|. .|| ...||.  ..  .
vttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale..d

CKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
..|| .|||..|.||.|.|.||. ..| |.|  ..|...|||.||. ||..|.|
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 267-539 2.1e-64 212.6 In-house 1-268 (319) alignment 
Range on Protein: 267-539
Range on HMM: 1-268/319.0
GKTEIPVSKFREKMDTLHRansvTKKANIHVEFKNLHTLTPTpsanSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDV
|.|||.| ...|.. .|.     | .  .. |||.|.. ...    .|.|    .|.||||...||. .| |  |.    . ..|||||||....|... 
gdteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerek

FLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEET---CVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDSGES--MTVEQFEMLGWGmSH
|.|||.|| ||.||.||. .. .. ..|||..| |.    . .|||||       | || .. | . ....|....   |.|    .| .|  . |   |
fiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWp.dh

NKPDSPVSLLGLIEAVQGSIKTaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
. |..  ||| |.. .. | .  | .|| .||| .|.|| | |..|  ..|........|.|. |.|||  |. ||..
dvPekatslldllkrirksrek.tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqr
0045098 (Phosphotyrosine protein) phosphatases II 3-267 3.2e-64 212.3 In-house 23-275 (278) alignment 
Range on Protein: 3-267
Range on HMM: 23-275/278.0
SPWEVASKEKNKPKNRFRNIIAYDHSRVVlekvdgdphsDYFNANYLSVSiyriQniCLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRC
| ...| ...|..|||...|..||||||.          || ||.|...     .    | .  .|    . .||||.|.... .|||.|.|.| |.  |
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy....p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

RQYWPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKK----ESEEKRTIVQYHYLSWPDMGVPEYY--TTLISFTDTVKQHHTKHQRGHTELSQ-SL
 ||||   ..... |||.. ||..|...| ..|||.|       |. |.|.. ..|||.|||.|||..   . ...... ..... ....  .   .   
aqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

FPLLLSPVCSAGVGRTGTFICLYNMLDMMkeEGRVDIFSFISKMRENRIK-MVQTKEQYIFLYNALLEVYLSG
 .      ||||||||||....| ||...  ||.||... ....|. |   .||..|||.||| .|||..| |
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0045450 (Phosphotyrosine protein) phosphatases II 282-539 2.3e-63 210.1 In-house 16-289 (307) alignment 
Range on Protein: 282-539
Range on HMM: 16-289/307.0
TLHRANSVTKKANIHVEFKNLHTLTPTPsANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSI-GSTDYINASFL--------NTFQKKDVFLATQS
 | . .  . .. .. ||. |  .|...  .......   |..|||..||||....| .|  ...  ...||||||.         ... .|. |.|||.
llvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPEEGSI-ALETLEVTALDSESTMNFVKRRFTVTS--DSGESMTVEQFEMLGWGmSHNKPDS
|||.|||| ||. ..... |||||.||.|     |.||||.||.    . . || |. |   ... |...||    .||| || .| ..||   |. |.|
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp.dhgvpps

PVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNT---IDIFQAVKRLRSSRPNMVET
. .|| .||.|.  ... ...|| .|||  |.||.|.|.|.. ... |.|..|   .|...|||.||. ||..|..
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn
0037934 (Phosphotyrosine protein) phosphatases II 5-263 6.4e-63 207.9 In-house 2-241 (243) alignment 
Range on Protein: 5-263
Range on HMM: 2-241/243.0
WEVASKEKNKPKNRFRNIIAYDHSRVVLekvdgDPhSDYFNANYLSVSiyriQNiclFFVSSAPNTASLTA----FWRMIWQENVATIVMVTNLIEAGKD
. .|... |..|||...|..||||||.|     .. |||.|||.  |      .   ......| . ..      ||||.|.... .|||.|.|.| |. 
fsiallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt....pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgre

RCRQYWPknpRSVeVMGDFSLFLLEVEQFSDHIVRTLIVKKKE-SEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHTELSQslfpLL
 | ||||    .| . |||.  ||..|...| .|||| .. .. ....|....||||.|||.|||.  . |..| | |...  .    ... |.      
kcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg....gp

LSPVCSAGVGRTGTFICLYNMLDMMkeegRVDIFSFISKMRENRIK-MVQTKEQYIFLYNALLEV
.   ||||||||||.|..| ||...    .||... . ..|| |   .||| .||.||| |||| 
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 317-539 1.6e-62 206.2 In-house 38-262 (314) alignment 
Range on Protein: 317-539
Range on HMM: 38-262/314.0
GRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEET---CVQYWPEEGS
 .   ||.|||. |||. .| |. |       |.|||||........   |..|| ||..||.|.||| .| .|  ||||.|| |..   |..||||...
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

IaLETLEVTALDSESTMNFVKRRFTVTS---DSGESMTVEQFEMLGWGMsHNKPDSPVSLLGLIEAVQGSIKTatCKGPAIVHCVNGIGRSGVFCALWSV
.  . ..|. ...|   ..|.| |.|.       |  .| ||. ||| . |. | |  .||.|.  |. | .    .|. .|||..| ||.|.|.|. .|
v.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpd.hdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidiv

MEKLRKDNTIDIFQAVKRLRSSRPNMVET
.. .......|.|.||| |||...|||||
ldmieregvvdvfnavktlrsrkvnmvet
0040439 (Phosphotyrosine protein) phosphatases II 315-539 4.2e-62 205.3 In-house 4-231 (249) alignment 
Range on Protein: 315-539
Range on HMM: 4-231/249.0
RSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPEE
. ..   |..|||.|||||....|..|   ..   .||||||...... |. |.||| |||.|||| ||. ..... |||||..|.|    .| ||||..
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GSIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSV
||.  ... || |. |.  ... | ...|    ||| || .. ...|   |. |.|. .|| .||||.  .... ..|| .||| .|.||.|.|.|.. .
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

MEKLRKDNTIDIFQAVKRLRSSRPNMVET
.| |.| ...|...||| ||| ||..|..
leqlekelgvdleeavkllrsqRpgavqn
subfamily_PTPN3_pd Subfamily PTPN3 7-265 2.9e-61 201.8 In-house 35-276 (280) alignment 
Range on Protein: 7-265
Range on HMM: 35-276/280.0
VASKEKNKPKNRFRNIIAYDHSRVVLEKVDgdpHsDYFNANYLSVSIYRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYW
.| | .| .|||.|.|..||. || |.. .     || ||||... |   . .  . ..  | . . | ||.|.|.... .|||.|.|.| |. .| |||
aarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PKNPRSVEvMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqrghtelSQSLFPLLLSpvCSA
|..  ..| .|.||. . . .. . ...| |..|.||..|.|.|.|  ||.||| |||.  . ...|...|.. .          | .  |...   |||
Petedele.ygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..........sgkeePvvvh..Csa

GVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYL
|.|||| .| |   | .. ..  | .   ...||. |  .|||..|| |. .|.|.|| 
GigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPRD_pd Subfamily PTPRD 349-539 5.8e-61 201.8 In-house 75-266 (564) alignment 
Range on Protein: 349-539
Range on HMM: 75-266/564.0
STDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTV-TSDSG
..|||||||.....|.  ..||| ||..|.|| ||. .. .. .||||..| |   . | .||||.|.   . |.||  ..|   ... | |.. ...| 
gsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkss

ESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKtaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
||..|.||    |  .|. |.|. ||| ||. |. . .  . .|| .||| .|.||.|.|... ...|......|.||.| ||.||. |. ||.|
esreVrqFhFtsWP.dhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
DSPc_SM00195 297-539 9e-61 200.9 In-house 4-247 (263) alignment 
Range on Protein: 297-539
Range on HMM: 4-247/263.0
VEFKNLHTLTPTPsanSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVML
 ||..| . |..    ...... . |..|||. .||| ...|  |  . .  ..|||||..... .||  . ||| |||.|||| ||. .. |...||||
eefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NELDE---ETCVQYWPEE--GSIALETLEVTALDSESTM-NFVKRRFTVTSDS-GESMTVEQFEMLGWGMShNKPDSPVSLLGLIEAVQGSIKTAtcKGP
.| .|   |.| .|||||  |.   ....|.  . |..  ....| ...| .   |. .|.|... .|  . . |||. |.| |..||. | .|   .||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..sgp

AIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 .||| .|.||.|.|... ....||......|||. ||.||..||.||.|
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
PTPc_SM00194 297-539 9e-61 200.9 In-house 4-247 (263) alignment 
Range on Protein: 297-539
Range on HMM: 4-247/263.0
VEFKNLHTLTPTPsanSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVML
 ||..| . |..    ...... . |..|||. .||| ...|  |  . .  ..|||||..... .||  . ||| |||.|||| ||. .. |...||||
eefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NELDE---ETCVQYWPEE--GSIALETLEVTALDSESTM-NFVKRRFTVTSDS-GESMTVEQFEMLGWGMShNKPDSPVSLLGLIEAVQGSIKTAtcKGP
.| .|   |.| .|||||  |.   ....|.  . |..  ....| ...| .   |. .|.|... .|  . . |||. |.| |..||. | .|   .||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..sgp

AIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 .||| .|.||.|.|... ....||......|||. ||.||..||.||.|
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 6-262 9.7e-61 199.9 In-house 1-239 (239) alignment 
Range on Protein: 6-262
Range on HMM: 1-239/239.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNIClFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
| | |  || |||. ||..||||||||||.  |||||| ||.||    |     . .  .    ..|   ||||.|||  . |||.| |||  | .|.||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrd..ydgspka.yiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy

WPKnprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVkqhhTKHQRGHTElsqslfPLLLspVCS
||    |     .. . | . | |.|.|.||... .    |.| . |||.  ||| |||.| |... .   .    ||     .       | ..   ||
wpd...stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki....tkdslpgar......pwvi..hcs

AGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
|||||||.|. .  ||   |..  |||| ..  .||.| .|||| |||.|.. |.||
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 8-262 1.3e-60 199.5 In-house 2-238 (239) alignment 
Range on Protein: 8-262
Range on HMM: 2-238/239.0
ASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNIClFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWP
| |  || |||. ||..||||||||||.  |||||| ||.||    |     . .  .    ..|   ||||.|||  . |||.| |||  | .|.||||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrd..ydgspka.yiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

KnprSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVkqhhTKHQRGHTElsqslfPLLLspVCSAG
    |     .. . | . | |.|.|.||... .    |.| . |||.  ||| |||.| |... .   .    ||     .       | ..   ||||
d...stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki....tkdslpgar......pwvi..hcsag

VGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
|||||.|. .  ||   |..  |||| ..  .||.| .|||| |||.|.. |.||
vgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 289-539 1.7e-60 199.5 In-house 17-264 (288) alignment 
Range on Protein: 289-539
Range on HMM: 17-264/288.0
VTKKANIHVEFKNLhtlTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDW
 ....... |...|   ..  . .|   || . | ||||...|||.. .|  |       ..||||||...  .|| ...|||.||..||.| |.| .. 
arnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

KCPVIVMLNEL---DEETCVQYWPEEGS-IALETLEVTALDSESTMNFVKRRFTVTsDSGESMTVEQFEMLGWgMSHNKPDSPVSLLGLIEAVQGSIKTA
|   ||||.||   ....| .|||...       ..||...|. . .||.|.. .   ... ... |.. |.|   |. |.|   ||.|.. |. . .  
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaW.pdhgvPeskapllellrqvkvanqad

tcKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
   || |||| .|.||.|.| ||  ..........||.. .|..|| .|...|.|
..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 308-539 3.8e-60 198.6 In-house 32-265 (318) alignment 
Range on Protein: 308-539
Range on HMM: 32-265/318.0
TPS-ANSFRSgRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---T
... . |..|   ..|..|||. .||. .. |  |    .  ..|||||.... ...|  ..|.|.|||.|.||.||. .. .. ||||| .. |.    
seetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkak

CVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQgSIKTATCKGPAIVHCVNGIGRSG
. .|||..||.....| |.. .. .. ..| |.|.||  .. || .| |...  |   .. |.|..||| |.  |. .... . .|| .|||  |.|| |
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWp.degvpesgaslldlvrqvs.kaqqksgagpivvhCsaGvGrtG

VFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
||.|. ...|........|.|| ||.||. |. || |
vfiavdillerikaealvDvfqtvkqlreqrnlmvqt
Y_phosphatase Protein-tyrosine phosphatase 322-539 6.5e-60 197.8 Pfam-A 1-222 (235) alignment 
Range on Protein: 322-539
Range on HMM: 1-222/235.0
NRKKNRFPDILPLERNRPYLacPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWP--EEGSIAL
|.||||..|||| ...|  |   || |..|||||........|  |.||| ||..|.|| ||. .. |. |||||..|.|   |.| ||||  ||.|   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

ETLEVTAL-DSE-STMNFVKRRFTVTSDSGES--MTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIktATCKGPAIVHCVNGIGRSGVFCALWSVME
....|.   ...  . ... | ...... .||   .|.|. . .|   |. |.|| ||| ||..|. |   ....|| .||| .|.||.|.|.||. ..|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

KLRKDNTIDIFQAVKRLRSSRPNMVET
.|......|..|.||.||..||.||..
qleaeeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 322-539 6.5e-60 197.8 In-house 1-222 (235) alignment 
Range on Protein: 322-539
Range on HMM: 1-222/235.0
NRKKNRFPDILPLERNRPYLacPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWP--EEGSIAL
|.||||..|||| ...|  |   || |..|||||........|  |.||| ||..|.|| ||. .. |. |||||..|.|   |.| ||||  ||.|   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

ETLEVTAL-DSE-STMNFVKRRFTVTSDSGES--MTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIktATCKGPAIVHCVNGIGRSGVFCALWSVME
....|.   ...  . ... | ...... .||   .|.|. . .|   |. |.|| ||| ||..|. |   ....|| .||| .|.||.|.|.||. ..|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

KLRKDNTIDIFQAVKRLRSSRPNMVET
.|......|..|.||.||..||.||..
qleaeeevdvlqivkelRkqRpgmvqs
0042113 (Phosphotyrosine protein) phosphatases II 317-539 1.6e-59 196.6 In-house 4-228 (245) alignment 
Range on Protein: 317-539
Range on HMM: 4-228/245.0
GRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGS
..   |..|||..||||....| .|  .|.   .||||||. .... .. |.||| |||.|||| ||. ..... .||||.|..|   ..| ||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

IALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTaTCKGPAIVHCVNGIGRSGVFCALWSVME
.  ... || |. |.  ... | ..||   ..|| .| ..  |.|   |. ||.. .|| ..|.|.  ..  . .|| .|||  |.||.|.|.|.. ..|
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmle

KLRKDNTIDIFQAVKRLRSSRPNMVET
 |.|  ......|||.||| ||..|.|
qlekelgvsleeavkelrsqRpgavqt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4-306 1.7e-59 196.2 In-house 36-281 (392) alignment 
Range on Protein: 4-306
Range on HMM: 36-281/392.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsiyRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGkdrcr
|  || || |..|||..||. || .||.|| .|  |.|||.|| |.      ..|   .  | .||.|||  ||||..||||.||.|||.| |.      
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip....sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

qywpknprsvevmgdfslflleveqfsdhivrtlivkkkESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQrgHtelsqslfPLLLSpv
                                         ...||. |.|.  ||| .||.. ..|. |   || .. ..   |        ||..   
.......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..h........pliih..

CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFKNL-
|||||||||  |.. ...   |.   ||.| |....|..|  |||||||| |.| |.||  |  .| ||| .| .....|. .     ..    ||..| 
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefrslk

--HTLT
  ||.|
ashtvt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 290-540 1.8e-58 193.1 In-house 19-269 (305) alignment 
Range on Protein: 290-540
Range on HMM: 19-269/305.0
TKKANIHVEFKNLHTLtptpsANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWK
... .. ...|.| ..      .|.  |. . |..|||. .| .|. .|  |.   | . .||||||.......|. ....|.||.|||.| ||| .. |
ysdkgleaqykslyee.....eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveek

CPVIVMLN---ELDEETCVQYWPEEGSI--ALETLEVTALDSESTMNFVKRRFTVTS--DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIK
  .||||    | ... | |||||. .    .. ..|.  ..... ....|.....   .. || || |...  |   |  |... ||| ||. || . |
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWP.dhGvpqfatsllslikrvqkdqk

TAtCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
    . | .||| .|.||.|||.|.   .|.|.|....|.|. .|.|||.|..||.||
kd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 6-262 2e-58 192.6 In-house 13-262 (270) alignment 
Range on Protein: 6-262
Range on HMM: 13-262/270.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvsiYRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
.. .  ..|  ||...|.   ..||.||... |... |.||||.       .. . .  . .|  ..|..||||||.|.| .|||.|.| | |...| .|
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPKNPRSVEVM--GDFSLFLLEVEQFSDHIVRTLIVKkKESEEKRTIvQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHqRGHTELSQSLfPLLLSpv
||..| .   .  |. . . |. |. . .|.. | .. ...||.| .  ..| .||| |||.   . .| .. .|  .. . | ..||...  |||    
Wpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravr.rsekeldkae.PllvH..

CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||||||||||.| |  .. ...|...||. . |...|..|...||. ||| |||.|..|
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN23_pd Subfamily PTPN23 8-262 3.3e-58 191.8 In-house 38-278 (288) alignment 
Range on Protein: 8-262
Range on HMM: 38-278/288.0
ASKEKNKPKNRFRNIIAYDHSRVVLEkvdgDPHSDYFNANYLSvsiyRIQNICL-FFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYW
|  ...  |||.|.|. |||.||.|.    . . || || ..      .   |  | .. ||   .|  ||.|.... . .|||...  | || .. .||
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvk....dlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYw

PKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHTElsqslfPLLLSpvCSA
|..    .. ||.|. | .|.. . |. |.|... ..........  .. |||..|||.   ||. | | |.......||          ||..   |||
PedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......Plvvh..Csa

GVGRTGTFICLYNMLD-MMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||||||.| ..|  .  . |..| .||   .|..||.|  |||.|||. |.|.| ||
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 299-539 8.4e-58 190.7 In-house 22-262 (315) alignment 
Range on Protein: 299-539
Range on HMM: 22-262/315.0
FKNLHTLtPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNE
 ...| | | | .   |..| .|| ||||. .||||...|  |     .   ||||||.......   ..|.| ||. .|.|.||. .. |   |||...
seefhdl.pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

LDEE---TCVQYWPE--EGSIALETLEVTALDSESTMNFVKRRFtVTSDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSikTATCKGPAIVH
..|.    | ||||.    |. . ...|. |. |.. . |.|.. || .| || || ||.. .|   .  .    ||| || .|...    . . . .||
kqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewP.dkGvdkqtssllklikevkad..ngkkefsllvh

CVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
|. |.||.||.... .|...... ...|.|. || ||. || .| |
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt
subfamily_PTPRB_pd Subfamily PTPRB 271-539 1.3e-57 190.0 In-house 7-270 (293) alignment 
Range on Protein: 271-539
Range on HMM: 7-270/293.0
IPVSKFREKMDTLHRANsvtkKANIHVEFKNLHTLTptpSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLAT
| ..|| | ...... .    ....  |...|...    . ..  . ....||.|||. .||| . .|  ||   .  ..|||||.... .. .  |.||
iklekfeehvkkmkads....dlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPEE-GSIALETLEVTALDSESTMNFVKRRFTVTSdSGESMTVEQFEMLGWgMSHNKPDS
| |||.||.|.||. .. |. .|||| .| |.    | .|||..  ...   ..|| . .|.. ..| | ....  . |...|.|.. . |   |. |..
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsW.pdhgvPek

PVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
. .|| ....|. .|.... |.| .|||  |.||.|.| ||  ...........|||  | .||..| ..| |
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 11-269 1.4e-57 189.9 In-house 45-283 (287) alignment 
Range on Protein: 11-269
Range on HMM: 45-283/287.0
EKNKPKNRFRNIIAYDHSRVVLEkvdgDPHSDYFNANYLSvsIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNP
..||.|||...|. .|  ||.|.    . | || || ..    |. ..   | .. .| .  .  ||..|...|| .|||.... |  .. | ||||.. 
sqnkdknRltqilvpdnyrvllk....gehpdyinavfid..gykekk..afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

RsvEVMGDFSLFLLEVEQFSDHIVRTLIVKKKE-SEEKRTIVQYHYLSWPDMG-VPEYYTTLISFTDTVKqhhTKHQRGHTelsqslfPLLLspVCSAGV
    |.|.... ||. |. .. |.|.| ||.|. ...|....||.. .|.. | |.|. | |. . . .|   |...||.|       ...    ||..|
s..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk...tqrkrgnt.......sivv..hCsdtv

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKT
||...|.     ..  |.|| .|.|. . ..|  . ..||| |||.|.....||   |..|
GrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-264 3.5e-57 188.5 In-house 40-283 (290) alignment 
Range on Protein: 7-264
Range on HMM: 40-283/290.0
VASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDP--HSDYFNANYLSvsIYriQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQ
|.  ..||..|||.||. ||  |..| .. |..    .| || |.    |  ..   . .  .| .  |  ||..||||.|. |||.|| || ||..|.|
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik..gy..kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

YWPKNprSV-EvMGDFSLFLLEVEQFSDHIVRTLIVKKKES-EEKRTIVQYHYLSWPDMG-VPEYYTTLISFTDTVKqhhTKHQRGHTelsqslfPLLLS
|||..  .. . .| ||. ||. |.... | |.| ||.|.| ..|....||.  .|.. | |... | |....  .|   |...|| |       .... 
YWpds..dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk...tqrkrgnt.......sivvH

pvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
  ||..|||...|. ... .. .| || .|.|. . ..|  . ..|||..|| .... .|.  
..CSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
0045098 (Phosphotyrosine protein) phosphatases II 312-539 5.6e-57 188.6 In-house 23-257 (278) alignment 
Range on Protein: 312-539
Range on HMM: 23-257/278.0
NSFRSGRASINRKKNRFPDILPLERNRPYlacpgsigstDYINASFLNTFqkKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYW
...  .    |..|||..||||....| .          ||||||.....  .. |.||| |||.||.| ||. ......|||||.|| |     |.|||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PEEGSIALETLEVTALDSESTMNFVKRRFTVTS-----DSGESMTVEQFEMLGWGmSHNKPDSP--VSLLGLIEAVQGSIK-----------TATCKGPA
||.||.  . ..|| |. | . ....|...||       ..||..|... .|.|   |. |..|   |.| |.| ..  .|           .   .|| 
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwp.dhgvpslpilksflellefirealkllaslllsslllldsggpv

IVHCVNGIGRSGVFCALWSVMEKLrkDNTIDIFQAVKRLRSSRPN-MVET
.|||  |.||.|...|.. ..| |  ....|...||| ||| ||. .|..
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqn
subfamily_PTPRA_pd Subfamily PTPRA 305-540 7.3e-57 187.7 In-house 41-281 (330) alignment 
Range on Protein: 305-540
Range on HMM: 41-281/330.0
LTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---
|  .|  ...       |..|||...||| . .| .|.    . ..|||||||.. ...|| |.|.| |. .||||.||. ...|   |||| ||.|   
lPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerke

ETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVT--SDS---GESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATCkgPAIVHCVN
| | ||||.||...   . |.  |.. . ..  | | |.  .|.    .|  |.|| . .|      |  |. .| |...|.   .  .   | .|||  
ekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkklnqqsag..pivvhcsa

GIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
|.||.| |..| .|.|... .. .|.|..|||||  ||.|| |.
GvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd
subfamily_PTPN13_pd Subfamily PTPN13 6-263 1.1e-56 187.1 In-house 30-268 (273) alignment 
Range on Protein: 6-263
Range on HMM: 30-268/273.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGdphsdYFNANYLSVSIyrIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
||. |..|| |||.||.. ||..|| |..  |     | ||... | .   ..   . ..  |   . . ||.|.|. ..  |.|||.  | || .|..|
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPKNPRS-VEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTkhQRGhtelsqslfPLLLspVC
||.. .. . | . . . ||.|.. ..  ||.| ||..||.| | ... .. .||| |||   . |. |   |.. .|  ..|         |..    |
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dag.........Pivv..hc

SAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
|||.||.||.|... .|.... .  .|.   . |.|| |  .||||.|||| |.|.|||
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 318-539 4.1e-56 185.0 In-house 5-227 (250) alignment 
Range on Protein: 318-539
Range on HMM: 5-227/250.0
RASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE--ETCVQYWPEEGSIA
.   |..|||. ||..|.  |  |    .   .||||||||....... |.|||.||..|.||.||. .. |  .||||..| |  .|. |||| |..  
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaek

LETLEVTALDSESTMNFVKRRFTVTSDSGESM-TVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATcKGPAIVHCVNGIGRSGVFCALWSVMEKL
   . |. |..|   ...||.. ... . ..  .| |.. . |      |.   . |.|.. || | . |  ..| ||.| .|.|||| |.|. .|.|.|
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWP.dkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgrsGafiaidavlerl

RKDNTIDIFQAVKRLRSSRPNMVET
.|....|.|. .|.||  ||..||.
kkekvvdvfkvikvlrkdrphaves
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 285-539 4.7e-56 185.4 In-house 26-276 (319) alignment 
Range on Protein: 285-539
Range on HMM: 26-276/319.0
RANSVTKKANIHVEFKNLHTLTPTPSANSFrsGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRL
. .   .. ...|||...  |..  .  .|       |. |||. .||. ..|.  |     .  .|||||||.. .|.|| ..|.| ||.||..|.||.
ksdfdddltklevefrracklgvnladqtf..anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrm

AFDWKCPVIVMLNeldEETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDSG--ESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIK
 ....|  ||.|    .. | |||| .. |  |  .|     | | ..| | . .. |.   .   . || .|||   . .||.|. |. |.. |.   .
iweyncstivllt...kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwp.dvGvpdypsdlmrlvkkvrhlts

TATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
    . . .|||  |.||.||. .|  ......... .|... |. ||  |...|. 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 292-539 7.6e-56 184.4 In-house 20-269 (297) alignment 
Range on Protein: 292-539
Range on HMM: 20-269/297.0
KANIHVEFKNLHTLTPtPSANSFRSGRA--SINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKkdVFLATQSPLPNTVEDLWRLAFDWK
. | |... . . | . |.|| . .  |   .| .|.|. .||| ...|  ||  ..  . ||.||||......   ...|| | ..||.|.|.. .| .
qknrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeq

CPVIVMLNELDEE--TCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDS-GESMTVEQFEMLGWGMSHNKP-DSPVSLLGLIEAVQGSIKTAT
  .|||||...|.   | .||...|. .. .. |. |  ..   |.|| ..|| ..      |.|.. . |     .  ||  ||| ||. |. . .. .
vstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna

cKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 .|| .|||..|.|| ||.... ||. . ......|||. ||.|| .||..| |
.egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 13-262 1.6e-54 179.9 In-house 28-266 (274) alignment 
Range on Protein: 13-262
Range on HMM: 28-266/274.0
NKPKNRFRNIIAYDHSRVVLEKVDG-DPHSDYFNANYLSVsiYRIQNIClFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPR
.. |||...|.  ..|||.||. .. |. |.| ||||.    |. .. . .     | .  .. |||||.||.|  |||.|.| || ...| .|.|..  
sqtknryktilPnensrvllesessededssyinanyikG..ydeeska.yvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

S--VEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESeeKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHTELsqslfplllSPVCSAGVG
    |  ||...   .. .  |. ||.|..|. |.  .|... | | .|||. .|.  .||... . |.. .....   .              ||||.|
yeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv.........vvhCsaGiG

RTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||| ||   . .  ..||. ||... ....| .|  ||||.||| ....|| .
rtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 12-262 2.1e-54 179.3 In-house 2-237 (237) alignment 
Range on Protein: 12-262
Range on HMM: 2-237/237.0
KNKPKNRFRNIIAYDHSRVVLEKVDGDphSDYFNANYLSVSIYriqNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPR
.|| |||. ||.|||||||||.   ..  ||| ||.||            .  .  |  .|   ||.|.|||. . |||.| |||  . .| .|||.  .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdg...tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq

SvEVMGDFSLFLLEVEQFSDHIVRTLIVKKK-ESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHhTKHqrghteLSQSlFPLLLSpvCSAGVGR
  .  | ... |   |.|||. ||.|.. |. . .| | | ||.. |||| |||.. ..|. |   . .. ..|      .|.|  | ..   |||||||
p.aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinr.sph......vses.gpwiih..csagvgr

TGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
|| |. .  ||   ||.  |||. ..  . |.|  ..|||.||.|.....||
tgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 297-539 3.1e-54 179.4 In-house 2-240 (284) alignment 
Range on Protein: 297-539
Range on HMM: 2-240/284.0
VEFKNLHTLTPTPSANSFrsGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVML
|||...  |..  .  .|       |. |||. .||. ..|.  |     .  .|||||||.. .|.|| ..||| ||.||..|.||. .. .|  ||.|
vefrracklgvngtdqtf..anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll

NeldEETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDSG--ESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATCKGPAIVHC
    .. | |||| .. |  |  .|     | . ..| | . .. |.   .  .. || .|||   . .||.|. |. |.. |.   .    . . .|||
t...kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhranivvhc

VNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
  |.||.||. .|  ......... .|... |. ||  |...|. 
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 7-285 9.8e-54 177.4 In-house 42-300 (439) alignment 
Range on Protein: 7-285
Range on HMM: 42-300/439.0
VASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKdrcrqYW
.|..| ...|||.... |.||.||.|... | ||| |.||||.    |  ..  |.  . .|.  .   |||........||||.|||.|. |     ||
laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG..yyddk..lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....yw

PKNPRSveVMGDFSLFLLEVEQFSDHIVRTLIV--KKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfPLLLspVC
| .     . || ..      .. ....| . |  ..  .| .||..|.||..|||  ||   . .. |  ...    |.. |         |...   |
psdaev..cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeyg.........pvvv..hc

SAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHR
||||||||| |.|   |. .| | .|||   .. .|..| .|||.  ||.|.|||.||    |.. . . .|. ....   
sagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefnagfs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 271-539 9.1e-53 174.0 In-house 2-268 (290) alignment 
Range on Protein: 271-539
Range on HMM: 2-268/290.0
IPVSKFREKMDtlhrANSVTKKANIHVEFKNLHTltpTPSANSFRSGRASINRKKNRFPDILPLERNRPYLA-CPGSIG-STDYINASFLNTFQKKDVFL
|||.|| | .      . .. .   . .|| |..   . | ..   | .| |...||| .|.. . ||  |   .|    . .||||.... ...|  ..
ipvdkfgefva....nghakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyi

ATQSPLPNTVEDLWRLAFDWKCPVIVMLNE---LDEETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDSG--ESMTVEQFEMLGWGMSHNK
|||.|..||. | |.|  . |...|||| .    ....| ||||.... |..  ... |. |.. ....|.. |....   .. .| |...  |    . 
atqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkv

PDSPVSLLGLIEAVQGSIKTAtcKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
..   .|| . | ..   |.   ... .||| ...|||.||||.   ..| ...  ||.|| .|..|. .|..|.|
tnpqtillvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqt
subfamily_Ptp69D_pd Subfamily Ptp69D 269-539 1.1e-52 174.1 In-house 2-271 (307) alignment 
Range on Protein: 269-539
Range on HMM: 2-271/307.0
TEIPVSKFREKMDTLHRANSVTKKAnihvEFKNLHTLtptPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFL
..|.. . .|.. . .|     ..     |...|..     .  | . .    |  |||..|| . ...|  |.      ..|||||||......|  |.
gaiaiddleealksrkrdtdfglak....eyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfi

ATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDS------GESMTVEQFEMLGWGm
| | |. .|..| ||.  . .  .|||| .|.|     | .|||.|  .  . . |.  ..|.. ....| . |.          .|  | |.. .||  
aaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.

SHNKPDSPVSLLGLIEAVQGSIKTAtcKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
  . |... .|| ||| |.   |.   ..| .||| .| ||||.| || |....|......|||. || ||| |. .|. 
DskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 289-539 1.1e-52 173.9 In-house 16-264 (315) alignment 
Range on Protein: 289-539
Range on HMM: 16-264/315.0
VTKKANIHVEFKNLHTLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDW
  |||. .  ||. .   |      ..  . . |..|||. .|.. .. |..|        .||.||.|.. ..||. ..|.|.|....|.|.||| |. 
aqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfee

KCPVIVMLNEL---DEETCVQYWPEEgSIALETLEVTALDSESTMNFVKRRFTVTSDSgESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSiKTAT
..  ||||..|   ... . .|||..  .    . ||  . |   ..  | ..|.... .  .| |...  |    . | . ..|. ||  |.   .|..
digkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswp.dmgvpkytiplmnlirtvkqh.htns

CkGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
  |. .||| .|.||.| |..| .|....  .| ||........|. | .||..
v.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqv
subfamily_PTPRG_pd Subfamily PTPRG 271-539 5e-52 171.9 In-house 1-272 (563) alignment 
Range on Protein: 271-539
Range on HMM: 1-272/563.0
IPVSKFREKMDTLHRANsvtkKANIHVEFKNLHTLTPTPSANSfRSGRASINRKKNRFPDILPLERNRPYLA-CPGSIGSTDYINASFLNTFQKKDVFLA
.||..| . .  ||  .    .  .. ||..|.. | . . .   . ..  |..|||  .|.. .| |  |.  ||  .. |||||.... .||.. |.|
vpvkefakhvaslhadg....digfseefealqsetiskdlda.ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTS-------DSGESMTVEQFEMLGWGm
|| ||..|..| ||. .. .  .|||. .| |   . | .|||...|. ...|.||  ..| ..   .|....         .  .  .| |...  |  
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP.

SHNKPDSPVSLlgLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 |. |....    || ... |  . .  || .||| .|.||.|....| .........|....|. .|..|. |...|.|
dhgvPehslpv..LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
subfamily_CG7180_pd Subfamily CG7180 283-539 8.8e-52 170.6 In-house 3-275 (296) alignment 
Range on Protein: 283-539
Range on HMM: 3-275/296.0
LHRANSVTKKANIHVEFKNLHTLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLW
 .. ..|.|. . .||.| .  |||. . .  . |  . ||.||| ....| . ||..|   .   ..|||||.. ..| ||  .. |. |  .||.. |
kkflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefW

RLAFDWKCPVIVMLNE-LDEET-CVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSD-----------SGESMTVEQFEMLGWGMSHNKPDSPVS
|| .| ..  .|.| .  | .  . .|||...      ..|  . ...  |...| | .|             . |  .| .|..  | . .. | |  .
rlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstna

LLGLIEAVQGSIKTA---TCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
|. |.. |.  .. .     .|| .|.. .| .||||..|.   .|...|.. .|.|.|||.|| |||..||.
lielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
0037934 (Phosphotyrosine protein) phosphatases II 317-539 1.7e-51 170.5 In-house 5-227 (243) alignment 
Range on Protein: 317-539
Range on HMM: 5-227/243.0
GRASINRKKNRFPDILPLERNRPYLacpgsiGSTDYINASFLNTFQKkdvFLATQSPLPNTVED----LWRLAFDWKCPVIVMLNELD---EETCVQYWP
..   |..|||..||||....| .|      ...|||||.. . . .   . ||| |||.||||     ||. ..... |||||.||.    | |.||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

eeGSIALETLEVTALDSESTMNFVKRRFTVTS--DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKT------ATCKGPAIVHCVNGIGRS
  |..  ....|| |..|.. ... | ....    .... .| ..  |.|   |. |||| .|| ....|.  |.       .  .|| .|||. |.||.
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFCALWSVMEKLrkdnTIDIFQAVKRLRSSRPN-MVET
|...|.. ....|    ..|...|||.||. ||. .|.|
Gtliaaylmllll....gvdleeavkllreqRpgkavqt
subfamily_PTPN1_pd Subfamily PTPN1 4-264 3.3e-51 168.7 In-house 23-271 (290) alignment 
Range on Protein: 4-264
Range on HMM: 23-271/290.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGdphsDYFNANYLSVSiyRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCR
| ..| ...|...||.|..  |||||..||. |     || ||. . .   ...    . ..  | .   . ||.|.|...  ..||. ...| .. .| 
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslvele..eakrs..yiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPKNPRSVEVMGD---FSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQhhtkhqrgHTELSQSLFPLLL
||||.. .. |.. .   ... |.. |. | ..||.| .......| |.|...||..|||.||||  .....|   |..           ||.   | ..
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre........sGslssdvGpavi

SpvCSAGVGRTGTFICLYNMLDMMKEEGR---VDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
   ||||.||.|||. .  .|  .....    |||   . ..|. |. ..||..|  | | |.||  
h..csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_PTPN14_pd Subfamily PTPN14 5-262 1.6e-50 166.8 In-house 41-294 (300) alignment 
Range on Protein: 5-262
Range on HMM: 41-294/300.0
WEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDpHSDYFNANYLSVSIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQ
 ..|. ..|..||||.... |...|| |     . ...| ||  ..||.   .    . |. .|    .. ||.|.|...|. |||.|. .| ||... .
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggker..syivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPKNPR--SVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGHTElSQSLFPLLLSp
|.||.    .    | | .    .|. .  | ..| .|   |.|.||..   |  ||| ||||  .. .|. . |.    | ..      .|  |.|.  
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves.keskPPvlvh.

vCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
 |||||||||  |    ..  .. . ..|| . ....|| |  .|||  || |.|..|..
.CsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 8-264 2.6e-50 165.8 In-house 33-277 (287) alignment 
Range on Protein: 8-264
Range on HMM: 33-277/287.0
ASKEKNKPKNRFRNIIAYDHSRVVLEKvDGDPHSDYFNANYLSvsIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWP
| .  .  |||. ... .|..||.| . .|.  ||| ||||..   |. ..   | .. .| .|..  |||.......|.....|  .| .. .| .|||
aeelaavkknryadvlPiddtrvllsa.egelGsdyinanyva..sytddea..fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

KNpRSVEVMGDFSLFLLEVEQFS-DHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHhTKHQRGHTELSqslfPLLLSpvCSA
.. .    .| .|. ||. .. . .. ||.| . . |..| | . |...||||| ...     || |.  ||||  . .|  .|      ||..   ...
er.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqh.ielardasevG....Plvvh..ddv

GVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
|.||.|... .. ....... ||||.   . ..|| |  .||.  |. .||.||   |
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 271-539 3.5e-50 165.6 In-house 2-263 (287) alignment 
Range on Protein: 271-539
Range on HMM: 2-263/287.0
IPVSKFREKMDTlhraNSVTKKANIHVEFKNLHTLTPTPsaNSFRSGRASINRKKNRFPDILPLERNRPYLAcpgsIGSTDYINASFLNTFQKKDVFLAT
|||.|| | ...    .  . . . .  |. |. .| ..  ..   . || |..|||. .||. . .|  |         |||||.|......|  |...
ipvekfgefvak....ghakgnegfknqftvleqvtqre..devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiia

QSPLPNTVEDLWRLAFDWKCPVIVML---NELDEETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDS--GESMTVEQFEMLGWGMSHNKPD
.||. ||. ..|.|  | . ..||||   .| ||| | |||||| |. |   ... |. | . ....|.. |. ..  |.  .|.|...  |    . ..
esPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvte

SPVSLLGLIEAVQGSIKTatCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
   .|| . | ..   |    ... .||| ...|||..|||    ..| ... .||.|| .|. |  .|..| |
pqtillvieemyktqrkr..gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 320-539 1.4e-49 163.6 In-house 41-261 (515) alignment 
Range on Protein: 320-539
Range on HMM: 41-261/515.0
SINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPE--EGSI
 || ||||. .|||....|  |         ||.|||....|.    ..|.| |.. .|.|.||| .. .   |.|...| |.    | .|||.    |.
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

ALETLEVTALDSESTMNFVKRRFTVTSDSGeSMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATckGPAIVHCVNGIGRSGVFCALWSVMEKL
 . ...|  .  |.  . .||..||. ..  | || ||.. .|   .  |    ||| || .|. .    |   | |.||  |.|| ||.... ||. . 
kfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWP.dkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvaha

RKDNTIDIFQAVKRLRSSRPNMVET
.. ...|.|. |. .|  || .| |
kttrmvdvfnfvtnirqkrpylvqt
subfamily_CG7180_pd Subfamily CG7180 8-269 2.9e-49 162.3 In-house 37-295 (296) alignment 
Range on Protein: 8-269
Range on HMM: 37-295/296.0
ASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvSIYRIQNiclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKdRCRQYWP
. ...|. |||  ... ||. ||||||.||. .||| || |   |  . ..   . |  || . .. .|||....|.. ..|..|.  .  |  . .|||
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd.sflkkke...yivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

KNPrsVEVMGDFSLFLLEVEQFSDHIVRTLIVKKK----------ESEEKRTIVQYHYLSWPD-MGVPEYYTTLISFTDTVKQHHTKHqrghtELSQSLF
..    |  |.. . ..|..|...   ||. ..||          .. |.|.. ....  |.    ||   ..|| .   |..   |      .  .   
nks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.....dedpeeg

PLLLspVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKT
|..   |.| |..|.| .. .   |.....|..||.| .. ..|..| ..|...|.| ..|. ||| .| .|.
Pvvv..vssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_PTPN12_pd Subfamily PTPN12 293-539 9.1e-49 160.9 In-house 8-262 (290) alignment 
Range on Protein: 293-539
Range on HMM: 8-262/290.0
ANIHVEFKNLHTLTPTPSAN---SFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWK
.. . ||..|..|.    |.   |  .|... |.||||. |||| . .|  |    .    |||||.|..  ..|  ..|.|.|||.|..| ||. .. .
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

CPVIVML---NELDEETCVQYWPEEGSIAL--ETLEVTALDSESTM-NFVKRRFTVTSDsGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKt
  ..||.    ||.   | .||||||  .|  ...|||  . . .  .|. | ..|. . .|| .|.||.   |   |. | |. ||| |||.|.   . 
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWP.DhgvPssaksllelielvrelqe.

aTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRK---DNTIDIFQAVKRLRSSRPNMVET
 . . | .|||  |.|| |. .|.  | | |..   ....|.|. | .||  |. .| |
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt
subfamily_PTPN6_pd Subfamily PTPN6 273-539 1.7e-47 156.9 In-house 6-282 (306) alignment 
Range on Protein: 273-539
Range on HMM: 6-282/306.0
VSKFREKMDTLHRANSVTKKANIHVEFKNLHTLTpTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGStDYINASFLN--TFQKKDVFLAT
 .. ..... |.. .. ..||... ||..| .   . .  | . |.   |..|||.  ||| . .|  |. |. .|| |||||....  . ...  ..||
akeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgs.dyinanyikkevkgsdksyiat

QSPLPNTVEDLWRLAFDWKCPVIVMLN---ELDEETCVQYWPEEGSIALE-TLEVTALDSESTMNFVKRRFTVT--SDSGESMTVEQFEMLGWGmSHNKP
|  |..||.| ||.... .. ||||.    |  .| |..|||.| .     ...|| ....|. ... |...|.  ....|. .| |..   |   |. |
qgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWP.dhgvp

DSPVSLLGLIEAVQGSIKTAT--CKGPAIVHCVNGIGRSGVFCALWSVMEKLR---KDNTIDIFQAVKRLRSSRPNMVET
 .|  .| ..| |.   .. .   .|| .||| .|||| | |  .  ......    |  ||| ..|| .|. |  .| |
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 5-272 5e-47 155.1 In-house 25-274 (283) alignment 
Range on Protein: 5-272
Range on HMM: 25-274/283.0
WEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGdphsDYFNANYLSVSIYRiQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQ
 ..|| ..||.|||...|...|  || |.        || || .. ||    ..   . .. .|       ||.|...|....|||.|.| |  . .| |
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksy.kqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPKnpRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESE-EKRTIVQYHYLSWPDMGVPEYYTTLISFtDTVKQHHTKHQRGhtelsqslfPLLLSpv
||||  |  |  |.| . | .       |.. |..... |  ..  .  | .  | ..|      .|. | . |.   |....|         |...   
yWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkg.........Pivvh..

CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIP
||.|.|||..|| .   .. .. |  ||.|. .  |||.|. .|||..|| ..... ||  | | |.| 
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_PTPN9_pd Subfamily PTPN9 294-539 5.6e-47 155.2 In-house 17-275 (297) alignment 
Range on Protein: 294-539
Range on HMM: 17-275/297.0
NIHVEFKNLHTltpTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVI
 .. |.....    .| .  |   .   | .|||. |.| ... |  ||       .|||||.|.. ...|. |.||| ||..||.| ||. .. .. ||
Glskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLNELDE---ETCVQYWP--EEGSIALETLEVTALDSESTMNFVKRRFTVT-SDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQ---G-----
||   . |     | ||||  || |.    |.|. .. |.. ....| .... .. .|| .|  | .|.|   .  |.|  ||| ..|.|.   .     
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWP.dyGvPssaaslldvlekvrekqalavke

--SIKTATCKGPAI-VHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
  . ..  ..|| | |||  ||||.| |..|   ...|.. .|.|....||.||. |  .. |
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
subfamily_PTPRN_pd Subfamily PTPRN 6-262 1.7e-46 153.3 In-house 49-290 (297) alignment 
Range on Protein: 6-262
Range on HMM: 49-290/297.0
EVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYRiqnICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQY
|||..|||  ||| .....|||||| |..   . .||| ||  .  .  |      .  . .| ......||.|.|.. |. ||..|.| | |  .|..|
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpr...apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPKNPRSVEVMgdFSLFLLEVE-QFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKqhhtKHQRGHTelsqslFPLLLspVC
||..  .|  .  . . |.       |..||.. .|  ...| ||. |.|.||||..|||    .|. |   |     |  || .       |...   |
wpdeGsevyhi..yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn....ksyrGrs......cpivv..hc

SAGVGRTGTFICLYNMLD-MMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
|.|.||||..| .  .|. ..|   ..|| . . ..|..| ..|.||.|. | . |. |
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN23_pd Subfamily PTPN23 288-539 1.1e-44 147.4 In-house 10-265 (288) alignment 
Range on Protein: 288-539
Range on HMM: 10-265/288.0
SVTKKANIHVEFKNLHTLTPTPsANSFRSGRASINRKKNRFPDILPLERNRPYLAcpgsIGSTDYINASFLNTFQK-KDVFLATQSPLPNTVEDLWRLAF
 .  |.... .||.|..      |...    | .. .|||. |||| ..||  |      .  |||||||..        |.|||.||..|. | |.. .
mldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvy

DWKCPVIVMLNELD---EETCVQYWPEEG--SIALETLEVTALDSESTMNFVKRRFTVTSDSG-ESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQG-
. | .||||| . .   .. . .||||.   .   . |.||  . ..| ..|.| ....  .  .  .|   ..  |  ..  |.|| .|| ....|.  
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWp.elGvPasPetllqfldevesa

-SIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTI-DIFQAVKRLRSSRPNMVET
 . .   .| | .|||  |.||.|||. .......|.|.| . || | |.|||  | .||..
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqe
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 294-540 1.1e-44 147.7 In-house 16-262 (281) alignment 
Range on Protein: 294-540
Range on HMM: 16-262/281.0
NIHVEFKNLHTLTptpSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVI
    |...|. .      |. .. .|  |..|||. .|   .  |  ..   .  .||||||.|.......  ..|||.|.|..... |.. .. |  .|
Gfieeyeklaaig...vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLN-ELDEE--TCVQYWPEEG-SIALETLEVTALDSESTMNFVKRRFTVTSDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSiKTATCKGP
||.  |....   | .|||..  .. . .. |. . .|.. ....|.|... .|||. .|||.. . |   |  |...  ||.  ..|.   ..   | |
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWP.dhGvPattkellefrkevlkl.tekktkap

AIVHCVNGIGRSGVFCALWSVMEKLR-KDNTIDIFQAVKRLRSSRPNMVETL
 ..||  |.||.|.. ||  .....  . ...|. . |. || .|  || |.
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4-265 1.6e-44 146.8 In-house 31-293 (301) alignment 
Range on Protein: 4-265
Range on HMM: 31-293/301.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDG--DPHSDYFNANYLSVsiYRiqNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDR
. .|  .|.||. |||.||  ||. |..|..       . .| ||.|..   |.  .   | ....|    |. |||.|||| ...||||||| |  |..
sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg..ys..ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk

CRQYWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESE---------------EKRTIVQYHYLSWPDMGV-PEYYTTLISFTDTVKQHhTKHQ
|.||||.   . | .| |.  | .   . |...| | || ...                . ....|..  .||. || .|. | | .  | ...   |  
ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrq.qkig

RGhtelsqslfPLLLSpvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALlEVYL
 |         |..    ||..|.|.|... .   |.  | || ||.|  .  .| .. ..|.| |||...|... . ||
gg.........pvvVH..CSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmyl
subfamily_PTPN13_pd Subfamily PTPN13 296-539 4e-44 145.9 In-house 14-254 (273) alignment 
Range on Protein: 296-539
Range on HMM: 14-254/273.0
HVEFKNLHTLTPTPSAnsfRSGRASINRKKNRFPDILPLERNRPYLACPGSigstdYINASFLNTFQKKDVF--LATQSPLPNTVEDLWRLAFDWKCPVI
  |||.|. | |. ..   ..|.   |..|||. ..|| .. |  |   |.     |||||...    || .  .|.| |||.||.|.|.. .. |. ||
aeefkelrelkpldtc...evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMLNELDEE---TCVQYWPEEGS--IALET-LEVTALDSESTMNFVKRRFTVT-SDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQgSIKTatC
.|.    |.    | .||||. .  . ..  |||. |. .   .|| |...|. |.||||  | ....  |   |. | |...|| ..  |. ...|   
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwP.dhgvPssaaellqfvaevr.rlqt..d

KGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
.|| .|||  ||||||.. ..  |.. . .|. .|. . |..||  |  .| |
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 294-539 7.3e-44 144.8 In-house 7-251 (283) alignment 
Range on Protein: 294-539
Range on HMM: 7-251/283.0
NIHVEFKNLHTLTPTPSANSFRSgrASINRKKNRFPDILPLERNRPYLACPGSigstDYINASFLN---TFQKKDVFLATQSPLPNTVEDLWRLAFDWKC
| .. ...|. |.  .      |  |. |..|||. .|.| ...|  |         |||||.|.      ...  ....|||| .|| |.|.. || | 
nnklfrevlkrlsvpdldadias..adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

PVIVMLNELDE---ETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSD--SGESMTVEQFEMLGWgmSHNKPDSPVSLLGLIEAVQgSIKTAT
  |||| .| |   . | ||||..||.    . ||  .  .   |... ...  .  . ... .  . . .|   .  .....  |  .. |. | .|  
taivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkfnkvi.slqtes

CKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 ||| .||| .||||..||.|. . ..... .  .|.|. || .|  |. .| |
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 320-539 1.5e-43 143.9 In-house 26-253 (274) alignment 
Range on Protein: 320-539
Range on HMM: 26-253/274.0
SINRKKNRFPDILPLERNRPYLACPGSIGS-TDYINASFLNTFQK-KDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSI
. . .|||. .||| |. |  |    |  . ..|||| ..  ... . ...||| ||||||.|.||. .  ...||||| .| |   . |..|.|.. ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----ALETLEVTALDSESTMNFVKRRFTVTSDSGeSMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATCK-GPAIVHCVNGIGRSGVFCALWS
      . .|..  .  .. ..  |.... . .  . .|  .    |   |. ||.. .|| |.. |. | .... | .|..|||  |||| |.| |   
eiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

VMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 . .||.....|... |  ||  |  ||.|
avrqlreeivvdvlkivcnlrldrGGmvqt
0051429 (Phosphotyrosine protein) phosphatases II 39-268 8.7e-42 139.0 In-house 2-228 (272) alignment 
Range on Protein: 39-268
Range on HMM: 2-228/272.0
PHSDYFNANYLSVSiYRIQNICLFFVSSAPNTASLTAFWRMiWQENVATIVMVTNLIEAGKDRCRQYWP----------KNPRSVEVMGDFSLFLLEVEQ
| |.|.||....   .|     ... |..| ...   |||. ..... |||..... | |.. | .|||           .      .|.....||..|.
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

FSDHIVRTLIVKKK-ESEEKRTIVQYHYLSWPDMGVPEYYttLISFTDTVKQhhtkhqrghtelsqslfPLLLSPVCSAGVGRTGTFICLYNMLDMMKEE
..|.|.|.|.....   .| |.. ..||..|||.|||. .  |... . . .                 .  .   ||||..||||...|. .|  . .|
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.................ggpvlvHCsaGkdRTGtvvallllllgvsle

GRVD--------IFSFISKMRENRIKMVQTKEQYIFLYNALLEVyLSGK
  ||        .. .....|. | ..||| |||.|||.||||. | . 
tivddYlltnlyleeaveelraqrpgavqteeqylflyeallel.lrsl
0041856 (Phosphotyrosine protein) phosphatases II 13-272 1.3e-41 137.6 In-house 1-179 (182) alignment 
Range on Protein: 13-272
Range on HMM: 1-179/182.0
NKPKNRFRNIIAYDHSRvvlekvdgdpHSDYFNANYLSVSIYRIQniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTnlieagkdrCRQYWPknprs
|..|||...|. |||||          ..|| |||..  | .  .    | .  .|   .. .|.||...... |||..|         ...|||     
nldknrysdilpydhsr..........dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp.....

vevmgdfslflleveqfsdhivrtlivkkkeSEEKRTIVQYHYLSWPDMGVPEyYTTLISFTDTVKQhhtkhqrghtelsqslfplLLSP---VCSAGVG
                               ....|...||.||.|||.|||.   .|..| ..|..                      |    ||||||
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevle...................eggpvlVHCsaGvg

RTGTFICLYNMLDMmkeegRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGKTEIP
||||....| |. .     .|.... .. .|. | .||.| .||.||. ||||..| .||...
Rtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_PTPN3_pd Subfamily PTPN3 313-539 8.7e-40 131.4 In-house 32-260 (280) alignment 
Range on Protein: 313-539
Range on HMM: 32-260/280.0
SFRSGRASINRKKNRFPDILPLERNRPYLAcpgsIGSTDYINASFLNTFQKK----DVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCV
.    | . | .|||. |||| .  |  |      ..||||||...|           ..||| ||..|..|.|.. .. |. .|||| .| |.    | 
aisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPEEG-SIALETLEVTALDSESTMNFVKRRFTVTSDS-GESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSiKtATCKGPAIVHCVNGIGRSGV
|||||.. .. . ...|.   ...| ..| | ....  .  |. .. |.  | |   |. ||.. ..| ..| |.   . .. . | .|||  ||||.||
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp.dhgvPddsadflefvervrkl.r.sgkeePvvvhCsaGigrtGv

FCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
. .|   . .. . . . . . |...|  | ..|.|
lilletalalieaaepvypldivrtmrdqramlvqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 292-539 1.6e-39 130.4 In-house 9-262 (287) alignment 
Range on Protein: 292-539
Range on HMM: 9-262/287.0
KANIHVEFKNLHTLTpTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGStDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCP
| ... |...|   .   |.  |..     . ||||. |.||.. .|  |.  |  || ||||| .. ...... |.|.|.|.. || |.||. .. .  
kddvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGs.dyinanyvasytddeafiaaqgPiaatvrdfwravletrsa

VIVML-NELDE--ETCVQYWPEE-GSIALETLEVTALDSES-TMNFVKRRFTVTSDSG-ESMTVEQFEMLGWgMSHNKPDSPVSLLGLIEAVQGSI---K
.....  |..|    | .||||    . .    |..|| .    ..  | . .    . |.  |.|...| |  ..  . . |.|. ..  |.  |   .
svitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielar

TATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
 |.  || .||.  ||||||.. |.. ....| .   .|. ..| |||  |  .| .
dasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqa
subfamily_PTPRN_pd Subfamily PTPRN 289-539 2.6e-38 126.4 In-house 25-277 (297) alignment 
Range on Protein: 289-539
Range on HMM: 25-277/297.0
VTKKANIHVEFKNLHTLTPTPSANSfrSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTF-QKKDVFLATQSPLPNTVEDLWRLAFD
...| ... |.. | .    ||...   ..|  | ||||  ..|| . .|  |    |  ..||||||..     .. ...|||.||..|| |.|.. ..
lknkdrlekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvwe

WKCPVIVMLNELDE---ETCVQYWPEEGSIALETLEVTaLDSES--TMNFVKRRFTVT-SDSGESMTVEQFEMLGWgMSHNKPDSPVSLLGLIEAVQGSI
  . |||.| .|.|   . | .|||.|||   .  ||  | ||   . ... | | .   .. |. || ||  | |  ... | |. ||| .   |. | 
qGvvvivnltrleeegvkqckrywpdeGsevyhiyevh.lvsehiwcddylvrsfylknlqtsetrtvtqfhflsw.peegvPasaksllefrrkvnksy

KTATCkgPAIVHCVNGIGRSGVFCALWSVMEKLRKD-NTIDIFQAVKRLRSSRPNMVET
.  .|  | .||| .| ||.||....  |...| |  . |||  ... ||  ||..|.|
rGrsc..pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt
subfamily_PTPN1_pd Subfamily PTPN1 313-539 4.5e-38 125.6 In-house 23-256 (290) alignment 
Range on Protein: 313-539
Range on HMM: 23-256/290.0
SFRSGRASINRKKNRFPDILPLERNRPYLACpgsiGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWP
. |. .   ||..||. |. | .  |  |      ...||||||...  . |  .. || ||||||. .|.. .. |.  .||||.. |     |.||||
ptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

EE---GSIALE--TLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGV
..    .. ||  .|.|. .  |.. ... | . ..   . |. .. .|  . |      |.|| ..| ..  |. |   .. .|||..||  |||||| 
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwp.dfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCALWSVM---EKLRKDNTIDIFQAVKRLRSSRPNMVET
|| . ...   ||  . ...|| . .  ||. |  .. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 286-540 1e-37 124.5 In-house 8-279 (301) alignment 
Range on Protein: 286-540
Range on HMM: 8-279/301.0
ANSVTKKANIHVEFKNLHTLTPTPSANSFRsgraSINRKKNRFPDILPLERNRPYLACPGS--IGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWR
 . .... ... ..|.|.. .. ..  ...    . |.. ||| .| ... ||  |.   .  . ...|||||... ...|  | |.|.|. .|. |.||
hvaakhsnkfeeqykelkegedksctvgls....eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWr

LAFDWKCPVIVMLNELDEE---TCVQYWPEEGSIALETLEVTA--LDSEST-----------------MNFVKRRFTVTSDSgESMTVEQFEMLGWGMSH
| .. |   |||. .|.|.    | ||||.      |  ..|    ..                     ....|.| |.||  .|..| |...  |    
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdG

NKPDSPVSLLGLIEAVQGSIKtaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
  ..    |  . . ..   |    .|| .||| ....||||.|..   .|  . .  .|.|| .|..| |.| .| ||
vvreprtvLqviddvihrqqk..igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTL
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 321-539 2.1e-37 123.6 In-house 19-249 (270) alignment 
Range on Protein: 321-539
Range on HMM: 19-249/270.0
INRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQ-KKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSI--
 ..| ||. ||||  . |  |.   .   | |||| ... |. .|  ..|...|||.|... ||. .. | . |||. .| |   . | .|||.|     
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--ALETLEVTALDSESTMNFVKRRFTVTsDSGESMTVEQFEMLGWG--MSHNKPD---SPVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCAL
  .  ...|.|| .| .  ....| ... ..||.  .  | .  |      ...|   |. .|| ...||. | |    ..| .||| .|.||.|.. ||
kledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

WSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
  ... | ... .|. . ...||  |...|..
DiavrlLeetkkvdvlaiieelRkdRmalvqh
0036282 (Phosphotyrosine protein) phosphatases II 41-258 2.7e-37 123.5 In-house 2-164 (174) alignment 
Range on Protein: 41-258
Range on HMM: 2-164/174.0
SDYFNANYLSVsiYRIQNicLFFVSSAPNTasltaFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKnprsvevmgdfslflleveqfsdhivrtlivk
|||.||..|..  ..| .   ......| .     ||.|...... |.||.....| |. .| .|||                                 
sdyinaspldl..syitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

kKESEEKRTIVQYHYLSWPDMGVPEYYTtLISFTDTVKQHHtkhqrghtelsqslfplllS--------PVCSAGVGRTGTFICLYNMLDMMKeEGRVDI
 . . ..|...||.|| |||.|||.  . |..| . |....                   |          ||||||||||....| || ... |. ||.
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal...................sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvda

FSFISKMRENRIKMVQTKEQYIFLYN
.... ..|  | .|||| .||.||| 
ldlvrelRlqrpgmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 322-539 3.4e-36 119.9 In-house 1-156 (182) alignment 
Range on Protein: 322-539
Range on HMM: 1-156/182.0
NRKKNRFPDILPLERNRpylacpgsigSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNeldeetCVQYWPeegsialetlev
|..|||..|||| ...|            |||||...   .. . |.||| ||..||.| .|.  .... .||.|.      ...|||            
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp............

taldsestmnfvkrrftvtsdSGESMTVEQFEMLGWGMSHNKPdsPVSLLGLIEAVQGsiktatCKGPAIVHCVNGIGRSGVFCALWsvmekLRKDNTID
                     . .  .. |.  |.|   .  .  . .|| .||.|.        .|| .|||  |.||.|...|..     | | . ..
.....................ellerlgiqylylpwpDhgvpd..ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay.....lmkklgvs

IFQAVKRLRSSRPNMVET
...||| .|| ||.||.|
leeavklvrsrRpgmvit
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 11-268 6.5e-36 118.9 In-house 39-281 (307) alignment 
Range on Protein: 11-268
Range on HMM: 39-281/307.0
EKNKPKNRFRNIIAYDHSRVVLeKVDGDpHSDYFNANYLSVSIYRIQNIClffvSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNP
. |  |||.... . |..|.|. |.||   |||  |||| ..|   . ||    .  |  ..   || |. ||.| ...|. ..|| .| .|.|||| . 
santdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkfic....aqgplentqysfwamaiqekvesvimlckvielakikceqywplee

RSVEVMGD----FSLFLLEVEQFS--DHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTkhqrghtelsqslfPLLLSpvC
    |.|.     |.  | .....  ....    .| . ... ||| .. .  ||| |||.   | | . ..|. ..               |...   |
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn..............pvvvh..c

SAGVGRTGTFICLYNMLD-MMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGK
||||||.|| ...  . | |.. .   |.  .. ..|..|   .||. ||..|.  ||| .|   
saGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 10-262 8.4e-35 115.1 In-house 30-257 (267) alignment 
Range on Protein: 10-262
Range on HMM: 30-257/267.0
KEKNKPKNRFRNIIAYDHSRVVLEKVDGDphsdYFNANYlsVSIYRIQNIclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNlieAGKDRCRQYWPKN
 |||. .||. . . ||..||.| . . .    | || |  |  |. .|   | |   |   . | |. .| ...|..||..|.   ...|  |..|| .
aeknqernrlddnlpyddtrvilrtkeee....yinasy..vegyktkna..fivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPk

PRSVEVMGDFSL-FLLEVEQfSDHIVRTLIVKKKEsEEKRTIVQYHYLSWPDMGVPEYYttlisfTDTVKQHHTKHQrghteLSQSLFPLLLSpvCSAGV
    .   |... . || |.  |. . || .| |. |  . .. |.|  |      . |         .    .| |     | .   ||..   ||.||
mgqakkyqdltvehslekee.ndyqiitlelkfkn.esahnvtlyyykkwnintnnkpy......lkplfgilaknq.....lengnrPlvva..csdGv

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
||.|||. .. .|. .|.|| .||| |. |.|. || .|.|||.||.... | |
GrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 12-263 1.1e-34 114.4 In-house 53-282 (290) alignment 
Range on Protein: 12-263
Range on HMM: 53-282/290.0
KN--KPKNRFRNIIAYDHSRVVLEkvDGDPhSDYFNANYLSVSiyriQniCLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKN
||    |||.....  | .||.|.  || .  ||  |||.       .    | ..  . ...   .|||. ||.||.|||. .||| || .| ||.|..
kntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGl....k..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

PRSVEVMGDFSLFLLEVEQFSDH-IVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQhhtkhQRGhtelsqslfPLLLspVCSAGV
   |  .|....   | ..  .. | .|| |..|.|  .  .  ..  ||||  |.    .|.    ....       |         |. .   ||||.
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.....asG.........pvvv..hcsaGi

GRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
||||||. .   |... .   .|.   .  .|. |.. ||   ||. | ..||..
GrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 291-540 4.9e-34 112.5 In-house 4-245 (267) alignment 
Range on Protein: 291-540
Range on HMM: 4-245/267.0
KKANIHVEFKNLHTLTPTPSANSFRsgRASINRKKNRFPDILPLERNRPYLacpgSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKC
.. .|. ||.... ...| |  |     |. |...||. | || . .|  |    .    .|||||.......|  |..|| || ||. | . .  | |.
eeceiekefelikkisdtsstisqs..iaeknqernrlddnlpyddtrvil....rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

PVIVMLNELDEETCVQYWPEEGSIALE----TLEVTALDSESTMNFVKRRFTVTSDSGESMTVEQFEmlGWGMSHNKPDSPVSLLGLIEAVQgsikTATC
||||.|    ..   ..|| .   | .    |.| .    |   . .   . .  .|   .|.  ..   | .  |.      |.|..   |        
pvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyyk..kwnintnnkpylkplfgilaknq....leng

KGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
  | .|.| .|.|||| |  . | .|....... |||. ....|| |. .|.|.
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
subfamily_PTPN14_pd Subfamily PTPN14 291-540 2.6e-33 110.3 In-house 21-282 (300) alignment 
Range on Protein: 291-540
Range on HMM: 21-282/300.0
KKANIHVEFKNlhtLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIgSTDYINASFLNTF--QKKDVFLATQSPLPNTVEDLWRLAFDW
.......|. .   ...      . ...   | .||||.|.|| | ||  |.      ||.||||| ...    |.  ....|.||..||.| |.. .. 
eegkvfteyer...ipkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeq

KCPVIVMLNELDE---ETCVQYWPEE----GSIALETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGS
.  .|||| |  |   | ...|.|..     ..  .  .||.  ||..  .. . ...    |.|  ||  .    |   |. |. . . |  .| ||  
gvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp.dhgvPeDvkgflsyLeevqsv

IKTA-------TCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
 . .         | | .||| .|.||.||      ... | ....||| ....|||  |  .|.||
rrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
0051429 (Phosphotyrosine protein) phosphatases II 349-539 3.6e-33 110.7 In-house 3-210 (272) alignment 
Range on Protein: 349-539
Range on HMM: 3-210/272.0
STDYINASFLNTFQK---KDVFLATQSPLPNTVEDLWRLaFDWKCPVIVMLNELD---EETCVQYWP------------EEGSIALETLEVTALDSESTM
 ..||||...... .   ........ |||.|..|.|||  .... .||.| ...    . | .|||            .. .| .  | || |  | . 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

NFVKRRFTVTS--DSGESMTVEQFEMLGWGMSHNKPDSpvsLLGLIEAVQGsiktatcKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTID-------
... |....|   . ||...| .. ...|   .  ...   || |.|...        .|| .|||  |..|.|...||. ... . ..  .|       
dyilrellltlllsagearevmhlhytdwpdhgvpqea...llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQAVKRLRSSRPNMVET
 ...||..||. ||..|.|
yleeaveelraqrpgavqt
0043147 (Phosphotyrosine protein) phosphatases II 37-257 8.6e-33 108.9 In-house 1-154 (172) alignment 
Range on Protein: 37-257
Range on HMM: 1-154/172.0
GDPHSDYFNANYLSVSIYRIQNICLFFVssapNTASLTAFWRMIWQENVATIVMVTNLieagkdrcrqywpknprsvevmgdfslflleveqfsdhivrt
||..||| ||.||....   . |.  ..        |  ||||...... .||..|.|                                          
gdegsdyinasyldlyyipdrfiatqgp....lrntladfwrmlkelgithivnltel..........................................

livKKKESEEKRTIVQYHYLSWPDMGVPeYYTTLISFTDTVKQHHTKHQrghtelsqslfpllLSPV---CSAGVGRTGTFICLYNMLdmmkeeGRVDIF
    .  . ..|...||.||.|||.|||     |..| . ..... . .                ||   ||||||||||....| ||       .....
...lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp..............ggpvlVHCsaGvgRtgtlvaaylml......lglsle

SFISKMRENRIKMVQTKEQYIFLY
  .. .|| | ..||...||.|||
eavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 13-265 2e-32 107.4 In-house 43-272 (288) alignment 
Range on Protein: 13-265
Range on HMM: 43-272/288.0
NKPKNRFRNIIAYDHSRVVLEkvdGDPHSdYFNANYLSVSIYRIQNIClffvSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRS
|  ..|..|.   | .|| |.    ||.  | .|| .| . |. . ||    ..||  . .  .|.|. ...|  |||...|.| ||..  .|.| .   
nptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlic....aqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe

VEVMGDFSLFLLEVEQFSDHIVR-TLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTkhqrghtelsqslfPLLLspVCSAGVGRT
   .| .     .  .  |..|. .|.  .|| |||  . . |.| |.| |||| | . . . . .|...               |...   .|||||||
karigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk..............Pivv..hssaGvGrt

GTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYL
||.|    .|.... .  . | |...|.||.| | .||. ||....  .||  |
gtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0046846 (Phosphotyrosine protein) phosphatases II 35-263 2.2e-32 107.6 In-house 6-172 (176) alignment 
Range on Protein: 35-263
Range on HMM: 6-172/176.0
VDGDPHSDYFNANYLSVSiyriqnicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKnPRSVEVmgdfslflleveqfsdhiv
   |...|| |||..  |        .. .  .|   .| .|..|...... ..|..|...| |. .| .|||   .....                   
lgldldldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi...................

rtlivkkkeseekrtivQYHYLSWPDMGVPEYyTTLISFTDTVKQHHTKHQRghtelsqslfpllLSPVCSAGVGRTGTFICLYnmldMMKEEGRVDIFS
                 ||..| |||.|||.. . |... . .... .....                 ||||.|||||....|    ... |  .... 
.................qylhlpwpDhgvpdl.elllellefirealkeggp.............vlVHCsaGigRtgtlvaay....llelekglsvee

FISKMRENRI-KMVQTKEQYIFLYNALLEV
 ....|| |  ..||| ||| ||| ..|..
alalvreqRplgavqtpeQyrflyefelll
0049772 (Phosphotyrosine protein) phosphatases II 308-540 2.4e-32 108.3 In-house 32-266 (314) alignment 
Range on Protein: 308-540
Range on HMM: 32-266/314.0
TPSANSFRSGRASINRKKNRFPDILPLErNRPYLaCPGSIGSTDYINASFLNTFqkkDVFLATQSPLPNTVEDL----------WRLAF--DWKCPVIVM
.......  ..   ||.|||..|||| . ||  |    .. ..||||||....|     |.||| ||..||.|.          ||. .  |... .|||
vlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LNELDEETcvqywpeegsialetL----------EvtaldsestmnfvkrrftvtSDS--GESMTVEQFEMLGWGMSHN
                     |..||. .                          .                    .    .|  . . .. | . .. .
srdevladelsrLdaAlgKtpllildgng...............neptaadlellk....................eelydpelferlgikylripvpDg

KPDSPVSLLGLIEAVQGSiktaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRkdntIDIFQAVKRLRSSRP-----NMVETL
 ....  .. ..|...        .|| .|||  |.||.|.|...  .| .|.    ... .|....|. ||     ...|.|
saplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieql
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 360-540 3.5e-32 106.3 In-house 231-424 (440) alignment 
Range on Protein: 360-540
Range on HMM: 231-424/440.0
TFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEETCVQYWPEE-GSIALETLEVTALDSEsTMNFVKRRFTVTSDSGESMTVEQFEMLGWG
 . ||. |.||| ||  || |.|||  |..   |.|||.|.. ||  ||| .  |...  . |    ||  || || |        |   . |||.  | 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgse.nmnrvkvrtlelkykeevheirqfevqtwp

MSH---------NKPDSPVSLLGLIEA--VQG-SIKTATCKGPA-IVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
            .  |. . |.  ..   .|  . ..    ||  .|||. ||  |||||..  ..|.| .| .||.|| .. || ||||.| ||
twiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 319-540 5.3e-32 105.8 In-house 45-265 (439) alignment 
Range on Protein: 319-540
Range on HMM: 45-265/439.0
ASINRKKNRFPDILPLERNRPYL-ACPGsIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEETCvqYWPEEGSIALE
 . .. |||. |. ...  |  |   || .  . |||| ... . ......||| |  .|..|.||| .. |.  |||| .| |     ||| .. .   
qeydqtknrykdvgafdhtrvtlqeipg.vphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsdaevcyg

TLEVTALDSESTMNFVKRRFTVTSD--SG-ESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSiKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKL
 . | .       |.| | | |  .  ..    || ||  . |   .| |     .| .. |.. . .     || .|||  |.||.|   ||   .|.|
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawp.dknvpaqashvldflrainsa.ndkeeygpvvvhcsagvGrtGtiialdialeql

RKDNTIDIFQAVKRLRSSRPNMVETL
. .| .||   || ||  | .||..|
klenkvdikgivkvlrkqrkqmvqal
0049260 (Phosphotyrosine protein) phosphatases II 68-258 9.6e-32 105.1 In-house 17-144 (152) alignment 
Range on Protein: 68-258
Range on HMM: 17-144/152.0
PNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWpknprsvevmgdfslflleveqfsdhivrtlivkkkeseekrtivQYHYLSWPDMGVPEYY
|   .|  ||||... .. ||||.|.| | ||. | ||.                                             ||..| |||.|||.  
pgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdls

TTLISFTDTVKQHhtKHQR-GhtelsqslfplllsPV---CSAGVGRTGTFICLYNMLdmmkeeGRVDIFSFISKMRENRIKMVQTKEQYIFLYN
  |. . . ....  .... |              ||   ||||||||||....| ||       .|... ... .|| | ..|....|..|||.
qlllflllfiekl..aldkgg..............pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 9-174 2.7e-31 103.6 In-house 29-190 (297) alignment 
Range on Protein: 9-174
Range on HMM: 29-190/297.0
SKEKNKPKNRFRNIIAYDHSRVVLEKVdgDPHSDYFNANYLSVSiyRIQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPK
 ..    |||.|.|.|.| .|| | .|   . .|| ||.|.       ..   . ..  |  |..  ||.......| .||||..| | |.|.|  |||.
krnsslrknryrdilatddtrvkllrv..iterdyinadyvvfp..deeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

NPRSVEVMGDFSLflLEVEQFSDHIVRTLIVK--KKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFT
        ||. .    . ..||.  |  . .      .|.| .    .||||| |||     |  | 
vvqerlkagdvvv..eflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_ptpA1_pd Subfamily ptpA1 9-221 3e-31 103.6 In-house 43-253 (418) alignment 
Range on Protein: 9-221
Range on HMM: 43-253/418.0
SKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSvSIYRIQNICLffVSSAPNTasLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPK
 |..|  |||. ||.  .|.|| |.|..    ||| ||||.    |  | ||       |||  .. ||||.|.. .  |||..   |  . .| .|||.
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.gaypkqfict..qgplpnt..iadfwrmvwenrcriivmlsresencrikcdrywpe

NP---------RSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVkqhhTKHQRGHTELSQSLFPLL
.             ||.| .|. |.|| |  .. . |  ..     | | | ||.|  |||  .|..   .  .  ..    |..|      |.   |..
qiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsi....tnrqnqiipssdrnvpii

LSpvCSAGVGRTGTFICLYNML
.   |||||||||||     |.
vh..csagvgrtgtfctavimm
0044763 (Phosphotyrosine protein) phosphatases II 25-264 8.8e-31 102.3 In-house 2-171 (178) alignment 
Range on Protein: 25-264
Range on HMM: 2-171/178.0
YDHSRVVLEKVDGDPHSDYFNANYLSvsiyriQNiclFFVSSAPNtaslTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRsvevmgdfslfll
.|..||.|... | . |||.||..         .   ....|.|.     ........... .||..|. .| |.  | .|||..               
ldrtrvllsnleglersdyinaseil......pg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.............

eveqfsdhivrtlivkkkeseekrtiVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtkhqR--GhtelsqslFPLLLspVCSAGVGRTGTFICLYNMLD
                          .||... .||.|||. .  .  |.. .....       |         | |    |||||||.||....| |. 
..........................iqylhipipDhgvpdllehflefvefieeal....dekg........gpvlV..HCsaGvgRsgtlvaaylmkk

MmkeegRVDIFSFISKMRENRIkMVQTKEQYIFLYNALLEVY
.     ...... |. .|| |  .|.. .|. .||   |...
l.....glsleeaielvrerRp.ivpnpgqlrqLyefelrll
PTPc_DSPc_SM00012 149-262 2.8e-30 100.0 In-house 1-105 (105) alignment 
Range on Protein: 149-262
Range on HMM: 1-105/105.0
TIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRghtelsqslfpllL---SPVCSAGVGRTGTFICLYNMLDMMKEE-GRVDIFSFISKMRENRI
|. .|||..|||.||||. . .... . ||....|...                   .|||||||||||..|. .|.....| ..|||| .....|. | 
tvkhyhytgwpdhgvPeesdsilellravkknknkses.............skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp

KMVQTKEQYIFLYNALLE
.||||.|||.|||.||||
gmvqteeqylflyralle
0036282 (Phosphotyrosine protein) phosphatases II 350-539 3.2e-30 100.5 In-house 2-155 (174) alignment 
Range on Protein: 350-539
Range on HMM: 2-155/174.0
TDYINASFLNTFQKKDVFLATQSPLPntvedLWRLAFDWKCPVIVMLNELDEET---CVQYWPEegsialetlevtaldsestmnfvkrrftvtSDSGES
.||||||.|. .   . ..|.| ||.      |.. ..... ..|||.|. |     | .||||                                . ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

MTVEQFEMLGWgMSHNKPDSPVsLLGLIEAVQGSIKTaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRkDNTIDIFQAVKRLRSSRPNMVET
 .. |.  |.|   |. ||... || ....|.  ..    .|| .|||  |.||.|...|.. ..  |.  ...|... |..||. ||.||.|
rlgiqylylpw.pDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 322-539 5.2e-29 96.1 In-house 3-224 (237) alignment 
Range on Protein: 322-539
Range on HMM: 3-224/237.0
NRKKNRFPDILPLERNRPYLACPGSIgsTDYINASFLNTFQK-KDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNEL---DEETCVQYWPEEG-SIAL
|. |||. .|   . .|  |  .||   .|||||..|. |.     ..|.| || .. .|.|.. .. || |||||  |   .|. | .|||.     | 
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

ETLEVTALDSESTMNFVKRRFTVTSDS--GESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKL
  | |.    |   ..  | ....      |   . |...  |   .  |.   .|| .   .    .  .  || |.||  |.||.|.|  . ... . 
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswp.drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

RKDNTIDIFQAVKRLRSSRPNMVET
.. . .||.. |. .   || ...|
kekkvvdiynyvysieedrpyiiqt
0049772 (Phosphotyrosine protein) phosphatases II 6-268 5.7e-29 97.2 In-house 39-284 (314) alignment 
Range on Protein: 6-268
Range on HMM: 39-284/314.0
EVASKEKNKPKNRFRNIIAYDhSRVVLEKVDGDPhSDYFNANYLSVSiyriqniCLFFVSSAPNTASLTAF----------WRMI--WQENVATIVM---
 ||....|. |||. .|. .| .||.| .....  |||.||.|..         . | ....|.   .  |          |||.  .. || .|||   
lvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------VTNLIEAGkdrcRQYWPKNPRSVEvmgdfslflleveqfsdhivrtlivKKK--ESEEKRTIVQYHYLSWPDMGVPeYYTTL
                   ..| . |     .......   .                         .     .  .|....|... .|| ..|     .
evladelsrLdaAlgKtpllildgng....neptaadlellk.........................eelydpelferlgikylripvpDgsap.lledf

ISFTDTVKQHhtKhqrghtelsqSLFPLLLSpvCSAGVGRTGTFICLYNmldMMKEEgRVDIFSFISKMRENRI-----KMVQTKEQYIFLYNALLEVYL
 .| . ....  .             |.|    |.||.||||||....    .||   .|..   .. .|. |       .... |||.| ..|||| . 
deflefieea..d..........kggpvlvH..CkaGkgRtgtfvvaay...lmkll.gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

SGK
  |
flk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 319-539 1e-28 95.1 In-house 5-226 (239) alignment 
Range on Protein: 319-539
Range on HMM: 5-226/239.0
ASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQK-KDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSI
  .|. |||. .|.  ...|  |        .||||||.|  ..     ..|||  .  .  |.||. .. .  |||||  | |   . | ||||.  | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

AlETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSikTATCKGPAIVHCVNGIGRSGVFCALWSVMEK
    | ||   .|   ... | | ..     |   | |. .  |   .  |.   ..|||   .     .     | ..||  |.||.| |  . ... .
y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrq

LRKDNTIDIFQAVKRLRSSRPNMVET
 .|..|.|||. || .|  || ||.|
akkqktvdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 319-539 1.1e-28 95.0 In-house 4-225 (239) alignment 
Range on Protein: 319-539
Range on HMM: 4-225/239.0
ASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQK-KDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSI
  .|. |||. .|.  ...|  |        .||||||.|  ..     ..|||  .  .  |.||. .. .  |||||  | |   . | ||||.  | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

AlETLEVTALDSESTMNFVKRRFTVTS-DSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSikTATCKGPAIVHCVNGIGRSGVFCALWSVMEK
    | ||   .|   ... | | ..     |   | |. .  |   .  |.   ..|||   .     .     | ..||  |.||.| |  . ... .
y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrq

LRKDNTIDIFQAVKRLRSSRPNMVET
 .|..|.|||. || .|  || ||.|
akkqktvdifnyvkairedrphmvqt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 12-266 1.5e-28 94.4 In-house 47-289 (305) alignment 
Range on Protein: 12-266
Range on HMM: 47-289/305.0
KNKPKNRFRNIIAYDHSRVVLEKvdGDPHsDYFNANYLSVSiyriQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPR
... |||....   |. || ||     || .|  |||.|       |   |  . ||   . . || | .|..| .| |. ||.| |  .| .|.. . .
qeagknrykdvgcldnnrvkleg..pwph.eyihanyvstp....tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

SVE----------VMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDtvkqhHTKHQRGhtelsqslfPLLLs
 |           |  . |  |  ... . .. .| .| .   |..| . .||.  ||| |||   .... .       ...  .|         |. . 
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.....karpskg.........pivv.

pVCSAGVGRTGTFICLYNMLDMMKEEGRVD-IFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLS
  ||||.||||. . |  .|| . .   ..     . |.||.| . .|| .||.|... .|. .. 
.hcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
0051082 (Phosphotyrosine protein) phosphatases II 39-261 1.5e-28 94.7 In-house 1-150 (151) alignment 
Range on Protein: 39-261
Range on HMM: 1-150/151.0
PHSDYFNANYLSVSiyriqniclFFVSSAPntasLTAFWRMIWQENVATIVMVTNLIEAGkdRCRQYWPKNPrsvevmgdfslflleveqfsdhivrtli
|.|||.|..|.            ...|..|    | .|......... |||..... | |   | .|.|..                             
plsdyinfsyvtgg.........lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg............................

vkkkeseekRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQhhtkhqrghtelsqslF-PLLLSPVCSAGVGRTGTFICLYNMLdMMkeegrVDIFSFIS
         ........|.||| |.|... ....| . . .                  .  .   ||||.|||||...|| || ..     |.... ..
.........ievlhipildwpdpglplsfdavleflellld................kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleeale

KMRENRIKMVQTKEQYIFLYNALL
 .|. |  .||...|..|.. |||
eyrlkrpgvvqpnqqflfqlfall
0043147 (Phosphotyrosine protein) phosphatases II 349-539 3.9e-28 93.7 In-house 4-146 (172) alignment 
Range on Protein: 349-539
Range on HMM: 4-146/172.0
STDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELdeetcvqywpeegsialetlevtaldsestmnfvkrrftVTSDSGESMT
..||||||.|..  . | |.||| ||.||..| ||.  .... .||.|.||                                       ..  .... .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.......................................lydpellerl

VEQFEMLGWGmSHNKPdSPVSLLGLIEAVQGSIkTATCKGPAIVHCVNGIGRSGVFCALWSVMeklrkdNTIDIFQAVKRLRSSRPNMVET
. |.  |.|   |. | ..  || ..| ..  .     .|| .|||. |.||.|...|.. ..        .....||. .|. ||..|..
giqylylpwp.Dhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 11-264 4.2e-28 92.8 In-house 35-269 (281) alignment 
Range on Protein: 11-264
Range on HMM: 35-269/281.0
EKNKPKNRFRNIIAYDHSRVVLEK-VDGDPHSDYFNANYLSVSIYRIQniclFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKN
  |. |||. || . | ||| |.  .     .||  |||.   . .      . ..  |.  . . ||||||||| ..|||. ...|. ...| .|.|.|
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg....yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

PRSVEVMGDFSLFlLEVEQFSDHIVRTLIVKKKESeEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKqhhtkhqrghtelSQSLFPLLlspVCSAGVG
 . .  .  .|.   |       .| | .    |  | | | .. .  |||  |||    ..     ..             ..|  |..    ||||||
ahcclqfdklsvs.yedstvnkslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrkir.............arstppvi...hcsagvg

RTGTFICLYNMLDMMKEE-GRVDIFSFISKMRE-NRIKMVQTKEQYIFLYNALLEVY
|.||....   |. ..      ||   .|..|   |   ||| .||..... ||.. 
rsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_CG42327_pd Subfamily CG42327 13-178 1.2e-27 91.5 In-house 28-191 (319) alignment 
Range on Protein: 13-178
Range on HMM: 28-191/319.0
NKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVsiYRiQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNP--
 |.|.|. |..   ..||||...  |... |..|.|.    |. .  . .  . ..   | ..|||..|. .  .|| .|.| | | ..| .|.| .   
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrG..yd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

RSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKESEEKRTIVQYHYlSWPDMGVPEYYTTLISFTDTVK
 . .. ||. . | . |    ... ||..|. . || | .  | |  |.. .||   ..||.    |.
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
0046846 (Phosphotyrosine protein) phosphatases II 346-539 5.1e-27 90.2 In-house 8-158 (176) alignment 
Range on Protein: 346-539
Range on HMM: 8-158/176.0
SIGSTDYINASFLNTFqkkdVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSIALetlevtaldsestmnfvkrrftvtsd
  .. |||||... .      ..||| |||.|..| ... ..... ..|.|.|. |     | .||||. .  .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

sgesmtveQFEMLGWgMSHNKPDSpVSLLGLIEAVQGSIKTAtckGPAIVHCVNGIGRSGVFCALWsvmeKLRKDNTIDIFQAVKRLRSSRP-NMVET
        |.  |.|   |. ||.   || |.|...  .|     || .|||. ||||.|...|..     |.... .....|....|. || ..|.|
........qylhlpw.pDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 146-300 9.2e-27 88.4 In-house 87-230 (440) alignment 
Range on Protein: 146-300
Range on HMM: 87-230/440.0
EKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKHQRGhtelsqslfPLLLSpvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIK
| ||. |||| .||| |||..   .. . . |.. . |   |         |||.   ||||.||||  |.. ..|   |   ..||||||. ||.|| .
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagng.........pllvh..csagagrtgviiavdsilreakrsdqidifsfinsmrnnrpq

MVQTKEQYIFLYNALLEVYLSGKTEIPVSKFREKMDTLHRANSVTKKANIHVEFK
|||| ||| |...|.||  |.| | |      |... ..  |  | |. .. ||.
mvqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 287-537 1.3e-26 87.9 In-house 19-266 (290) alignment 
Range on Protein: 287-537
Range on HMM: 19-266/290.0
NSVTKKANIHVEFKNLHTLTPT-PSANSFRSgRASINR--KKNRFPDILPLERNRPYLACpGsiGSTDYINASFLNTFqkKDVFLATQSPLPNTVEDLWR
 .|.||.   .  . |..| |  |.    |.     |   ||||. |.   .. |  |   |  .  ||. | ...    | .|. || .| .|| |.||
sdvvkknvdelakeyleklkpylpvqylerk.ifdkntefkknrykdvvcndktrvilkd.G..ydGdyvhanyvkGl..kamfiltqGalkdtvidiwr

LAFDWKCPVIVMLNELDEE---TCVQYWPEEGSIALETLEVTALDSEST---MNFVKRRFTVT-SDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEA
.  . |  .|||| || |.    | ||.||.   .|   |.| | ||..    | .|. ..|   ||| .  .  ...  |   .  . | ..|| .. .
mvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp.dksvalstlallrtlri

VQgsiktaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMV
..      .  || .|||  ||||.| | |.   .. | .   .|. . |. || || | |
lr......kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 10-266 2.1e-26 87.5 In-house 32-272 (285) alignment 
Range on Protein: 10-266
Range on HMM: 32-272/285.0
KEKNKPKNRFRNIIAYDHSRVVLEKVDgdphSDYFNANYLSVSIyriQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKN
 | |   ||. .. . . .||||.. |     ||  |... .     ..   .  .  |   .|. ||.||.||..| ..|.  |.| | ..|  |.|..
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpg...kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

PRSVEVMGDFSLFLLEV--EQFSDHIVRTLIVKKKESEEKRTIVQYH--YLSWPDMGVPEYYTTLISFTDTVKQHHTKHQrghtelsqslfPLLLspVCS
   |  .| . . | |.  |  .  |. .| | . |      .   |     |||   ||    .| .   ||.   | .           |. .   ||
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek...........picv..hcs

AGVGRTGTFICL-YNMLDMMkEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLS
|||||| ||. . |  . .| |.  ....  . .||  |.. ||.. |..|||  |.| .. 
agvgrtatfvgidyatirim.enpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_ptpA1_pd Subfamily ptpA1 292-515 1.2e-25 85.2 In-house 20-257 (418) alignment 
Range on Protein: 292-515
Range on HMM: 20-257/418.0
KANIHVEFKNLHTlTPTPSANSfrSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDvFLATQSPLPNTVEDLWRLAFDWKCP
  .|. ||. |   .  ||  |   |    |  |||. .|||... |  |        .||||| ...    |. |..|| |||||. |.||. .. .| 
ihkikeefrllee.svgpsets..egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcr

VIVMLNELDEE---TCVQYWPEE-----GSIALETLEVTALD--------SESTMNFVKRRFTVTSdSGESMTVEQFEMLGWGmSHNKPDSPVS---LLG
.||||.   |.    | .||||.      ||  .  ||             .   . . |   .|   ||.  . |..  ||   || ||       || 
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwp.dhnipdhtqpfrqllh

LIEAVQGSI-KTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLR
 |   |  |  ..  . | ||||  |.||.| ||.   .|.|| 
sitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
0049260 (Phosphotyrosine protein) phosphatases II 359-539 1.1e-24 82.3 In-house 3-135 (152) alignment 
Range on Protein: 359-539
Range on HMM: 3-135/152.0
NTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWpeegsialetlevtaldsestmnfvkrrftvtsdsgesmtveQFEML
. . ..  |.||| |.|||..| ||.  .... .||||.||.|     | ||.                                          |.  |
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhl

GWgMSHNKPDSPVSLLGLIEAVQGSikTATCKGPAIVHCVNGIGRSGVFCALWSVMeklrkdNTIDIFQAVKRLRSSRPNMVET
 |   |. ||..  || |.....        .|| .|||. |.||.|...|.. ..      . .....||...|. ||..|..
pw.pDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 9-266 4.8e-24 79.5 In-house 51-291 (305) alignment 
Range on Protein: 9-266
Range on HMM: 51-291/305.0
SKEKNKPKNRFRNIIAYDHSRVVLEKVDgdpHSDYFNANYLSVSIyrIQNIcLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPK
| . .. |||.... . |.| | |.|      |||  |||. . .  | .   | ..  |   ..  || |. |..|  |||. . .| || .| |||| 
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpm..ipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa

NP-RSVEVMGDFSLFLLEVEQFS---DHIVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVkqhhtkhqRGhtelsqSLFPLLLSpvC
     .|. .   .  .   .       |  ||.      ..| .. . ..  ||| |||    | . .  ..        ||      |  |...   |
aqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai........rg......skvpivvh..c

SAGVGRTGTFICLYNMLDMMKEEGRVD-IFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLS
|||.||||| ...  .|. . |. ..  .  ..  .|..|   .|.  ||.|..  .|. .| 
sagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 295-537 1e-23 78.8 In-house 18-260 (307) alignment 
Range on Protein: 295-537
Range on HMM: 18-260/307.0
IHVEFKNLHTLTPT-PSANSFRSgrasiNRKKNRFPDILPLERNRPYLACPGSigSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVI
.  ||..|   ||   ....|..     | .|||. |.   ...|  .  .|   ..||| | .| .  |   |...| || ||. ..| .| . |   .
lvdefrvlakktpegvtveafsa.....ntdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLNEL---DEETCVQYWPEEGSI------ALETLEVTALDSEsTMNFVKRRFTVT----SDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGS
.|| ..    .  | |||| |         | .|. |. | .. ..   .    ||      ...| |.....   |   .  |.  .. . |.|||.. 
imlckvielakikceqywpleegqklvfgeapntisvanlgak.klapdedlinvttlkvdwaqksrtiqhlqwenwp.drgvpqinltainlleavryd

iktatcKGPAIVHCVNGIGRSGVFCALWSVMEKL-RKDNTIDIFQAVKRLRSSRPNMV
      . | .|||  |.||||   |.  |..|. .  |  |. . |. ||| |.  .
......tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyai
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 319-538 1e-23 78.5 In-house 47-265 (301) alignment 
Range on Protein: 319-538
Range on HMM: 47-265/301.0
ASINRKKNRFPDIlPLernRPYLACPG-SIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLN---ELDEETCVQYWPEEG--
| ....|.|.| . |    .|  |    . |    | | ...|  . . |.|||.||.|| ||.| .   ..   ||||    |  || | .| | .   
aylpkdkhryptv.Pc...kPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

SIALETLEVTALDSESTM--NFVKRRFTVTSDSGE--SMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSIKtatckgPAIVHCVNGIGRSGVFCALW
.. ..  ...  ..|. .  . .||.. |.  .|.  . ||  .    |   .. | | . |  |.| |. | |      | .||| .|||||  | .  
kldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewt.drgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigte

SVMEKLRKDNTIDIFQAVKRLRSSRPNMVE
 .  ..  |.||.. .|.|.||  | | | 
ylareveadptieltealkhlrehrwngvq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 297-412 1.7e-23 77.7 In-house 21-146 (392) alignment 
Range on Protein: 297-412
Range on HMM: 21-146/392.0
VEFKNLHTLtPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVML
. |...| | | | .   ....  || ||||. .|||....|  |     |  .||.|||....|. .  ..|.|.| . ...|.||. |. .   |.|.
lffeefhdl.pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

NELD-------EETCVQY----WPEEG
..|.         |. |.    ||...
tklkegdkgddartvaqfhftewPdkd
0044763 (Phosphotyrosine protein) phosphatases II 333-539 2.9e-22 74.6 In-house 1-156 (178) alignment 
Range on Protein: 333-539
Range on HMM: 1-156/178.0
PLERNRPYLACPGSIGSTDYINASFLNTFqkkdVFLATQSPlpntvEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSialetlevtaldsest
||.|.|  |  .  . ..||||||.   .    ..|... |     .| ..|  .... .||.|.| .|   . | .||||| .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

mnfvkrrftvtsdsgesmtveqFEMLGWGMS-HNKPDSPVSLLGLIEAVQGSIKtaTCKGPAIVHCVNGIGRSGVFCALWSVMEKlrkdnTIDIFQAVKR
                      ...| .... |. ||..  .| ..|...  ..  ...|| .|||  |.||||...|.. ...       .....|...
......................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRSSRPnMVET
.|. || .|..
vrerRp.ivpn
0051082 (Phosphotyrosine protein) phosphatases II 350-539 3.9e-22 73.9 In-house 3-138 (151) alignment 
Range on Protein: 350-539
Range on HMM: 3-138/151.0
TDYINASFLNTFqkkdvFLATQSPLPntveDLWRLAFDWKCPVIVMLNELDEE-TCVQYWPEEGsialetlevtaldsestmnfvkrrftvtsdsgesMT
.||||.|..  .     ..... ||.    | ..|  .... .||.|....|  .| .|.||.|                                  ..
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................ie

VEQFEMLGWGMShNKPDSPVSLLGLIEAVQGsiktatC-KGPAIVHCVNGIGRSGVFCALWSVMEKlrkdntIDIFQAVKRLRSSRPNMVET
| .. .|.|    . |.|. ..| ..|...       . .|| .|||  |.||.|...||. ....      .....|.. .|..||..| .
vlhipildwpdp.glplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp
0048076 (Phosphotyrosine protein) phosphatases II 126-262 6.8e-22 73.1 In-house 22-141 (145) alignment 
Range on Protein: 126-262
Range on HMM: 22-141/145.0
VEQFSDHIVRT-LIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHTKhqrghtelsqslfP--LLLspVCSAGVGRTGTFICLYNMLD
.|.. |. ..| | .   .. ..|...||.||.|||.|||. . .|..| . ..... .             .   |    ||||||||||....| || 
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.............ggpvlV..HCsaGvgRtgtlvaaylmll

mmkeEGrVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
    .| |.... . ..|. | ..|.. .|..||| ..||
....lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 59-280 8.2e-22 72.3 In-house 89-296 (301) alignment 
Range on Protein: 59-280
Range on HMM: 89-296/301.0
ICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDFSLFLLEVEQFS-DHI-VRTLIVKKKESE-EKRTIVQYHY
   | .. .| ...   || |. | .| .|||... .|  ...|..| | ....   .| |.. . . |.   ..|  ||| |.    . . ||.. | |
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

LSWPDMGVPEYYTTLISFTDTVKQHHTkhqrghtelsqslfPLLLSpvCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIF
 .|.| |||. .. |  . . ||. .               |...   ||||.||. .||    .   .. . ....   . ..||.| . |||..|  .
sewtdrgvPkshaelfdlmelvkksek..............Pivvh..csaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

LynALLEVY-LSGKTEIPVSKFREKM
.   |  || |. . .. .  . |..
m..tlGtvyrlikeygfdmkiyeeql
PTPc_DSPc_SM00012 448-539 8.9e-22 72.7 In-house 1-92 (105) alignment 
Range on Protein: 448-539
Range on HMM: 1-92/105.0
TVEQFEMLGWGMShNKPDSPVSLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKD-NTIDIFQAVKRLRSSRPNMVET
|| .....||    ..|... |.| |..||. . . .. ..| .||| .|.||.|.|.||  ....|.|  ...|||| ||.||..||.||.|
tvkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 11-270 4e-21 69.9 In-house 50-295 (310) alignment 
Range on Protein: 11-270
Range on HMM: 50-295/310.0
EKNKPKNRFRNIIAYDHSRVVLeKVDGDPHSDYFNANYLSVSIYRIQNIClffvSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNP
.|.  |||. ...  | ||| | |.|   . ||  |||.     |   ||    |  |   ..  |||||.||   .|... .  | |. .|  |||   
kkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstfic....sqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

rSVEVMGDFSLFL-------LEVEQFSDHIV-RTLIVKKKESEEKRT-IVQYHYLSWPDMGVPEyyttlisftdtvKQHHTKHQRGHTELSQSlfPLLLs
   |  |   .         .|. ...  .|   . | .. .. |   .   ..  |||.|||.            .. ||  ||  ... .   | .. 
.vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd............ekchtvpqrllaqvrhg..pcvv.

pVCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLeVYLSGKTE
  ||||..|... . |   .| ...  .||.   ..... .|.. .||. ||...    . ..  |.||
.hcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargete
0048179 (Phosphotyrosine protein) phosphatases II 133-258 9.8e-21 69.4 In-house 32-139 (144) alignment 
Range on Protein: 133-258
Range on HMM: 32-139/144.0
IVRTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHhtkhqrghteLSQSlFPLLLspVCSAGVGRTGTFICLYnmldMMKEEGrVDI
 | .|. .    ...|...||..|.|||.|||.... |..| . ....          |...  | |    ||||||||||....|    .||..| ...
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea..........leeg.gpvlV..HCsaGvgRtgtlvaay....lmkklg.lsl

FSFISKMRENRIKMVQTKEQYIFLYN
.. .  .|. |  .|.. .|..||..
eealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 295-533 4.5e-20 66.5 In-house 13-248 (281) alignment 
Range on Protein: 295-533
Range on HMM: 13-248/281.0
IHVEFKNLHTLTPTPSANSFRsgrASINRKKNRFPDILPLERNRPYLAC-PGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVI
.. || ||    |.  .  |      .| ||||. .|  |.  |  |        ||||| | .. .   |  .. || |  .|  |.||. .. .   |
fkqefsnlpgdppsdlctvfn...qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMLN---ELDEETCVQYWPEEGSIAL--ETLEVTALDSESTMNFVKRRFTVtSDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQgsiktaTCKG
|||    | . | | .|.| .   .|  . | |.  ||     .|  |. . |  ||.  . ..    |    . |.|   .| ..  ..      .   
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl.syegetrlithwlwkewp.dwqvpessevmlkilrkir......arst

PAIVHCVNGIGRSGVFCALWSVMEKLRKDNTI-DIFQAVKRLRSS-R
| ..||  |.|||| . |.   .. ..   |. || | | .|| . |
ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 12-109 5.9e-20 66.3 In-house 46-153 (350) alignment 
Range on Protein: 12-109
Range on HMM: 46-153/350.0
KNKPKNRFRNIIAYDHSRVVLE----KVDGDPH----SDYFNANYLSVSIYRIQNICLF--FVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDR
.   |||..||. |.|||| |.      |.  |    .|| |||||... . ..    |      ||    .  |...| . .|  |...|...| . ..
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CRQYWPKN
| .||.. 
cyrYWqeg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 296-539 6.7e-20 66.0 In-house 25-272 (305) alignment 
Range on Protein: 296-539
Range on HMM: 25-272/305.0
HVEFKNLHTLTPTPSANSFRSgraSINRKKNRFPDILPLERNRPYLACPGsigSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVM
. ||.... .      ..|.    . ...|||. |.  |..||  |  |      .|| | .. |  .   |. ||.|| .|  |.| . .. |   | |
raefvamkrfndfekmkafke...aqeagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifm

LNELDEE---TCVQYWPEEGSIALETLEV-----TALDSESTMNFVK--------RRFTVTSDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEavqg
| .| |     |..|.. .    ||  |        ..| .|..|.|          ...    ...  | ..    |      | . ...| |.|    
lcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwp.drgvpaadlailelle....

siKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQ-AVKRLRSSRPNMVET
  |. . ||| .|||  ||||.|    |  ....|   . |.  .  ....|  | | ..|
..karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 322-533 1.9e-19 64.3 In-house 52-269 (310) alignment 
Range on Protein: 322-533
Range on HMM: 52-269/310.0
NRKKNRFPDILPLERNRPYLACPGSIgSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEET---CVQYWPEEGSI-ALE
. .|||. |.. |.  |  |    |    ||| | ...|   .. |. .| ||  |. |.||. |. ..  |..|    ||    || |||  |   .  
ymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

TLEVTALdSESTMNFVKRRFTVTSDSGESMTVEQFEML---GWGM--SHNKPDSPVSLlGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSVME
 . || | |||. .|    ..||    .    ||   |      .    | ||  |       .|   . .   .|| .|||  |..| .| .||   ..
cirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.ekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkid

KLRKDNTIDIFQAVKRLRSSR
||.. . .|. . .  |. ||
kldrglkvdaeevktellksr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 335-537 2.6e-19 64.5 In-house 31-242 (290) alignment 
Range on Protein: 335-537
Range on HMM: 31-242/290.0
ERNRPYLACPGSIGSTDYINASFLnTFQKKDVFLATQSPLPNT-------VEDLWRLAFDWKCPVIVMLNELDEE-------TCVQYWPEE--GSIALET
| .|  |   |.  . ||| |... |. .   ...||||. ..       .|. | .| . |   .||| | .|.       .| .| ||.  ... .. 
eatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

LEVTALDSESTMNFVKRRFTVTSDSGESMTVEQFEMLGWGMShNKPDSPVSLLGLIEAVQgsiktaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLR-KD
|.|   . |   .. .|. .|. | .| .||.   . || .. | .... .|| ||. |.      . | |.|||||.|| || .. |.   . |.  . 
ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnkl.nvqedtktllsliqkvk......asktpvivHcvdGiSrsAalaaiilgyQkiaets

NTIDIFQAVKRLRSSRPNMV
. . . ...| ||. | ...
gsvkledvlkalrkqralai
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 12-275 5.5e-19 62.7 In-house 50-295 (302) alignment 
Range on Protein: 12-275
Range on HMM: 50-295/302.0
KNKPKNRFRNIIAYDHSRVVLEKVdgdpHSDYFNANYLSVSIYRiQNICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKdRCRQYWPKNPR
||  ||.  .. ..|. .| ||.       .| ||  ..|   . ..| |  .     ..|.  ||||..||.....|..    |  |    ...||.  
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

SVEVMGDFSLFLLEVEQFSDHIVRT--LIVKKKESEEKRTIVqYHYLSWPDMGVPEYYTTLISFTDTVkqhHTKHQRGHTELsqslfpLLlspVCSAGVG
. . .|.. .    ||. ...  |    .. .  |.   . | |.   |..  ||. |..||     |   ..|.. .  ..      ..   |   |.|
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv.yvltnWkqkkvpvkyaeliktaakv...fakkikadent......vi...vSknGaG

RTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLeVYLSGKTEIPVSK
| |.|. |   .. ....  . |   . ..|..| ..|.. .||..|| ||| .|.  | . |  |
RagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall.lyikkkvtkpeek
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 11-267 6.1e-19 62.9 In-house 41-279 (312) alignment 
Range on Protein: 11-267
Range on HMM: 41-279/312.0
EKNKPKNRFRNIIAYDHSRVVLekvDGDpHSDYFNANYLSVSIYRIQNIClffvSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNP
 | |  ||. ||  .|  |  |    ||    |  ||.. .     . .|    . .|   . | ||..      ..|.... ..| | ..| .|     
lkfkdlnrypniqcwdrgrftl...agd.enfyihanfvkictkperfvc....tqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv

RSVEVMgDFSL---FLLEVE---QFSDHIV-RTLIVKKKESEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHtKhqrghtelsqslfPLLlsPV
  |..  |  .   .  |.|   .  |.|  | | |  | . ..  . .| . |||| |.|.   |   .  .||. . |             |..    
gfvdle.dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.k.............pvi..ah

CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSG
||||||||||.. .  |.  ..   . ..      .| .| . |..  ||..   ..||.  | 
csagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_egg_pd Subfamily egg 312-539 6.2e-19 62.8 In-house 30-255 (307) alignment 
Range on Protein: 312-539
Range on HMM: 30-255/307.0
NSFRSGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNE-LDEETCVQYWPE
 |..   .. |..| | . .   .  |  |  .    . |.| |  ..     . |. .|.|| |||.|.||. |  ... ||||.   . | |  ||| 
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpk

EGSIALET----LEVTALDSESTM--NFVKRRFTVTSDSGESMTVEQFEMlGWGMSHNKpDSPVSLLGLIEAVqgSiKtatckgPAIVHCVNGIGRSGVF
  | .| |    |....|. .|.    |   .. .     | . .| ..   .  | .   ||. .| ..  .  | |      |..|....|. .....
aesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdv.ysplrvlrklrnl..s.k......pvvvqdilGvskaatl

CALW-SVMEKLRKDNT-IDIFQAVKRLRSSRPNMVET
 |.  .... ||   |   . .||. ||  |.  ||.
vaieiallsllrGpitkslvlravvflrlrrrlsves
subfamily_egg_pd Subfamily egg 4-139 9.7e-19 62.1 In-house 31-162 (307) alignment 
Range on Protein: 4-139
Range on HMM: 31-162/307.0
PWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSVSIYriqnICLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAgkDRCR
. . | .. |. | | . .   | ||| ||   |    |.  ||...        .  | .. ||   .   ||||..||.|  |||.|   |.  .|| 
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpl....lnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPKNPRSVEVM--GDFSLFLLEVEQFSDHIVRTLIV
 |||| .    |.  | . .  |.|.. .| . |   .
yywpkaesdslvtvpGslrienlkvdskadplfrvtkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 298-534 3.7e-18 60.2 In-house 29-269 (305) alignment 
Range on Protein: 298-534
Range on HMM: 29-269/305.0
EFKNLHTLT-PTPSANSFRSG-RASINRKKNRFPDILPLERNRPYLACPGsigSTDYINASFLNTF-QKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIV
||..|   | |  . . | .   | |.  |||. |.   ...   |. |     .||| | ..      .  |...| || .|....| .  . |   ||
efrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqiv

MLN---ELDEETCVQYWPEEGSIALETLEVTALDSESTMNFVKR-------RFTVTSDSGESMTVEQFEMLGWGMShNKPDSPVSLLGLIEAVQGSikta
||    ||    | ||||      ||      ..  |  . ..|        . .|   ...|.| ...   |      |   .. | |. |..||    
mlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdr.gvppckltslellsairgs....

tcKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTI-DIFQAVKRLRSSRP
  | | .|||  ||||.|   |.  ..||. ...    . . || ||  | 
..kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqra
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 324-423 2.5e-17 57.6 In-house 49-164 (350) alignment 
Range on Protein: 324-423
Range on HMM: 49-164/350.0
KKNRFPDILPLERNRPYLA--------CPGSIGSTDYINASFLNTF----QKKDV--FLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQ
 |||. .||| |..|  |            |. . |||||..|.      . .    ..|||.|||.||.| ... .  | .||..|....|   | | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEeGSIALETLEVTA
||.| ||.   |. ...
YWqe.gsydditvklas
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 420-539 2.5e-17 57.4 In-house 251-370 (392) alignment 
Range on Protein: 420-539
Range on HMM: 251-370/392.0
EVTALDSESTMNFVKRRFTVTSDSGESMTVEQFEMLGWGMSH-NKPDSPVSLLGLIEAVQGSIKTaTCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDN
 .. |.. |  .   ..  .. ..  | || |... ||     ..     ||| || ||.||  . . .   .|||. | ||.||||.    . .. . .
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstns.kkefsilvhclsgagrtgvfctameciaqiaegd

TIDIFQAVKRLRSSRPNMVET
..||||.|| ||. | ..|.|
svdifqtvkilradrmqfvqt
subfamily_eak_pd Subfamily eak 21-266 5.9e-16 52.8 In-house 59-307 (332) alignment 
Range on Protein: 21-266
Range on HMM: 59-307/332.0
NIIAYDHSRVVLEKVDGDPHsdyfnaNYLSVSIYRIQNICL-FFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDF
.|. ||.  | |     ..        |.  |.    ..   . .. ...   . |||.|. ...  .||.. . .| . ..  .|.|.. | .   | .
kivpydrylvrltssqlnrl......GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

SLFLLEVEQFSDHIVRTLIVKKkeSEEKRTIVQYHYLSWPDMGVPEYyTTLISFTDTVKQHHTKHQ-RGHTELSQSLF------PLLLSPV--CSAGVGR
 .   |  . .   .| |...|   .|   .  |..  | .. .| |   .... ...|.  .      ...| .|..      |   .|.  .. |  |
dverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsar

TGTFICL---YNMLDMmKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLS
.|.|. .    ...|  | .    .  .| |... ||. | .. |. |.|...|.  | 
aGvfvvidllirlidn.kkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 149-263 1.2e-15 52.1 In-house 216-343 (350) alignment 
Range on Protein: 149-263
Range on HMM: 216-343/350.0
TIVQYHYLSWPDMGVPEYYTTLISFTDtVKQHHTKHQRGHTELSQSLFPLLLSpVCSAGVGRTGTFICLYNMLD------MMKEEG-RV--------DIF
 . | ..  |.|...      ...  . ||..       .. | ..  . .|   ||||||||||.. |  .|       ....|  ..         |.
vvyqlqvknWkDlslllnPesilqale.vkndliddlfaeshldnarsspilv.hCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

SFISKMRENRIKMVQTKEQYIFLYNALLEV
  . ..|. ||.|||...|.||.|.|||  
iivnelrkqrismvqnldqfifiYeallfy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 290-540 1.1e-14 48.6 In-house 23-271 (302) alignment 
Range on Protein: 290-540
Range on HMM: 23-271/302.0
TKKANIHVEFKNLHTL-TPTPSANSFRSgrasiNRKKNRFPDILPLERNRpylaCPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTV---EDLWRLA
 ..|... |||...|. ... . ..|..     | |||. .|.  |. |.      ..    .|.||| ..  . .   . .| |  ...   |. ||..
ldtaevkkefkkidtmkvdlekCkafkk.....nlkknqsedvpildsnl....vkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmv

FDWKCPVIVMLNELDEE--TCVQYWP--EEGSIALETLEVTALDSESTMNFVkRRFT---VTSDSGESMTVEQFEMLGWGMSHnkpdSPVSLLGLIEAVQ
|. |.  .|.|   .|   |  ...|   .     ... |     |.. . .  |..   .  .  .|. ..   .  |  ..     ||.   ||....
fqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkk....vpvkyaeliktaa

GS-IKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
.   |.. .. ....  .||.|| |.| .|  ..||| |..   | . || .|| ||..|..|
kvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 72-278 1.3e-14 48.9 In-house 40-236 (255) alignment 
Range on Protein: 72-278
Range on HMM: 40-236/255.0
SLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDFSLFLLEveQFSDHIVRTLIVKKKESEEKRT--IVQYHYLSWPDMGVPEYYTT
.. .|...| | .  ..||.... |.|...| .|.| .     .. | ..   .    .| ..||| .  . .| |.|  .  |.|  |..   ||    
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LISFTDTVKQhhtkhqrghtelSQSLFPlllspVCSAGVGRTGTFIC---LYN-MLDMMK--EEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEV
.      |..            |.|..      .||.|.||. .|.    .|  |.  ..  | . .|  |.. ..|..| . ..|  |  |    .|..
ilnilkvvrd............sksvvv.....hCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

-YLSGKTEIPVSKFRE
 .  |. |   .. |.
vfpkgeleakyqeirk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 311-418 1.8e-14 48.3 In-house 22-132 (297) alignment 
Range on Protein: 311-418
Range on HMM: 22-132/297.0
ANSFRSGRASINRKKNRFPDILPLERNRPYLAcpGSIGSTDYINASFLNTFQKK--DVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCV
..|| | . .   .|||. |||  . .|  |   ..|  .||||| ..   ...    .. .| || .||.| |.| ..    ||||. .| |.    |.
gesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

QYWPEEGSIALET
 |||.     |..
pywpsvvqerlka
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 322-537 2.4e-14 48.0 In-house 35-253 (285) alignment 
Range on Protein: 322-537
Range on HMM: 35-253/285.0
NRKKNRFPDILPLERNRPYLACpgsiGSTDYINASFLNTFQK-KDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGS--IA
|   ||. |.  .|  |  |         ||| ||..    | .  ...|| |||.|. |.|.. .. |   ..||  | |   | |  |.||.    . 
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

LETLEVTAL--DSESTMNFVKRRFTVTSD---SGESMTVEQFEMlGWGMSHNKPDSpvsLLGLIEAVQGSIKTATCKGPAIVHCVNGIGRSGVFCALWSV
.   |.|      |.    .   .||.     | | . ... ..  |   .  |.       .||  .   |    . |  |||  |.||.  |  .   
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqv.pwwpdqlaped...arpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

MEKLRKDNTIDIFQAVKRLRSSRPNMV
  .. ..  |.... |. .|. | . |
tirimenpniemldivremramrfqav
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 12-266 2.8e-14 47.4 In-house 46-281 (303) alignment 
Range on Protein: 12-266
Range on HMM: 46-281/303.0
KNKPKNRFRNIIAYDHSRVVLEkvDgdphSDYFNANYLSVSIYRiQNIclffVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPR
||  |||| ..|  |||.| |   |    | |  |.|| .   . . |    ..  | . . . ||.|| ...|  ....    |  |      .|.|  
knmdknrfvdvicldhskvkls..d....ssyihasyleldssk.kai....ltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

SVEVmGDFSLFLLEVEQF---SDHIVRTLIVkkKESEEKRTIVQYHYLSWPDMGVPEYYTTliSFtdtVKQHHtKHQRGHTELSQSLFPLLLSpvcSAGV
 ..   . |. . |  .        .. | |   . . |  .  .|| .||   .|   .    |   |||   . |      |.|  .. .|    .|.
flkf.eersirvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsipsdgsp..kf...vkqiw.qlqsvlrkysdstptvyms...lsgc

GRTGTFICLY-NMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLS
||.|||  .    | . .|.  .|.   . ..|. |.. ||   |. ..|  | |  | 
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 352-539 2.8e-14 47.8 In-house 69-256 (288) alignment 
Range on Protein: 352-539
Range on HMM: 69-256/288.0
YINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSIALETL---EVTALDSESTMNFVKRRFTVTSDSGE
||.|  . . . |  .. .|.||  |.| ||.. ..     ||||.|| |   |   .|.| .   .        |.  . .     ||      |  ||
yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskege

SMT-VEQFEMLGWGmSHNKPDSPVSLLGLIEAVqgsiktATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVET
    | .  .| |   .  |.. .| | |.| .       ... | .||. .|.||.| .     ..| || |. . | . ...|| .| . ..|
ekvivkilhlleWd.ddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqt
0048076 (Phosphotyrosine protein) phosphatases II 459-539 2.9e-14 48.5 In-house 56-128 (145) alignment 
Range on Protein: 459-539
Range on HMM: 56-128/145.0
MSHNKPDSPVSLLGLIEAVQGSIKTatcKGPAIVHCVNGIGRSGVFCALWSVMEklrkdNTIDIFQAVKRLRSSRPNMVET
  |. ||..  || ..|...  .|    .|| .|||  |.||.|...|.. ...     . .....|....|| ||..|..
pDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn
0048179 (Phosphotyrosine protein) phosphatases II 459-539 3.4e-14 48.3 In-house 58-130 (144) alignment 
Range on Protein: 459-539
Range on HMM: 58-130/144.0
MSHNKPDSPVSLLGLIEAVQGSIKtatCKGPAIVHCVNGIGRSGVFCALWsvmekLRKDNTIDIFQAVKRLRSSRPNMVET
  |. ||..  || ..|...  ..    .|| .|||  |.||.|...|..     | | . .....|....|| ||..|..
pDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrrpgavpn
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 305-454 5e-14 46.5 In-house 81-227 (244) alignment 
Range on Protein: 305-454
Range on HMM: 81-227/244.0
LTPTPSAnsFRSGRASINRKKNRFPDILPLERNRPYLAcPGSIGSTdYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEETc
. | ||   ..      |  |||    ||.. ||  |.  ||.| | ||||||.  . .   .. || || .|  |.|.. .. .  |.|.|  ..||  
irpdpsv..mkdafnpnnswknregaglpfdfnrvpls.kgsmgnt.yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.

vQYWPEEGSIA--LETLEVTALDSESTMNFVKRRFTVTSDSGESMT-VEQFEM
 .|||.   .    | . ||  | .   |     . . ||  ||   .  |..
.eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 204-267 6.6e-14 46.1 In-house 5-68 (69) alignment 
Range on Protein: 204-267
Range on HMM: 5-68/69.0
CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSG
||.| |||||||..   .  .| |  ||||  .  ||  |  ||  . .|||...|| |    |
cssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 204-268 1e-13 45.4 In-house 4-68 (69) alignment 
Range on Protein: 204-268
Range on HMM: 4-68/69.0
CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVYLSGK
||.| ||||||| .   .  .| |  ||||  .  ||  |  ||  ...|.|...|| |    ||
cssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 374-538 1.3e-13 45.6 In-house 39-205 (255) alignment 
Range on Protein: 374-538
Range on HMM: 39-205/255.0
LpnTVEDLWRLAFDWKCPVIVMLNELDE---ETCVQYWPEEGSIALETLEVTALDSESTMNFVKRRFTVTSDSG---ESMTVEQFEMLGWgMSHNKPDSP
|  ||. ...     |  |.||| .. |   | | .|.| |    |   .|.   ..|. . | |  ..||  |   .  ||. ..  || . .| |. .
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW.ieknaPela

VSLLGLIEAVQGSiKtatckgPAIVHCVNGIGRSGVFCALWSVME----KLRKDNTI--DIFQAVKRLRSSRPNMVE
  .| .. .|. | |      . .||| .|||||  |    .|       |.. .|.  |  . .. |||.|.  ..
reilnilkvvrds.k......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 325-530 1.4e-13 45.3 In-house 46-255 (312) alignment 
Range on Protein: 325-530
Range on HMM: 46-255/312.0
KNRFPDILPLERNRPYLACPGSIgstdYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELD---EETCVQYWPE-EGSIALETLE
 ||.|.|   .| |  ||    .    || | |..   | . |..||.|| ||.  .|.||.   .  |..|  .     | |..|  .  | . ||   
lnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VT-------ALDSESTMNFVKRRFTV-TSDSGESMTVEQFEMLGWGmSHNKPDSPVSLLGLIEAVQGSiktatcKGPAIVHCVNGIGRSGVFCALWSVME
|         .   |  .  .| . |    .|.   .....   |   |  |||  . | |. ||.        | | | ||  |.||.| .. . |.. 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswp.dhgmpdscdtalrllsavkkd......kkpviahcsagvgrtgtlaliesmia

KLR---KDNTIDIFQAVKRLR
 ||   |.|  |.|  ... |
alrhprkqnvkdsfvllrkdr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-51 2.2e-13 44.4 In-house 37-85 (440) alignment 
Range on Protein: 3-51
Range on HMM: 37-85/440.0
SPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNANYLSV
.| ..||  .|| |||.|||.|||||||.||.| | |.||| || |.. 
qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 16-182 4.9e-13 43.9 In-house 22-192 (290) alignment 
Range on Protein: 16-182
Range on HMM: 22-192/290.0
KNRFRNIIAyDHSRVVLEKVDGDPHSDYFNANYLSVSiyriQNICLFfVSSAPNTAS-------LTAFWRMIWQENVATIVMVTNLIEAGKD----RCRQ
..| .. ..  ..||||.       .||. ||.....    ....|  ....| ..        .  || |. ||.|  .||. .  |  ..     | .
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcp....nglrli.ltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKEsEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDTVKQHHT
| |..      ......   . |.  | ..|.|.||  . ||. |.  . . .| .. |.|   ||.|  ..||...|
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkaskt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 65-258 4.9e-12 40.4 In-house 10-198 (199) alignment 
Range on Protein: 65-258
Range on HMM: 10-198/199.0
SSAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKES--EEKRTIVQYHYLSWPDMG
.  |   ... ||.|.|.     |||| .     .     |||    ..  .| .|.    .   .|. . .||. .. .     | | .| . || .  
tqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekt

VPEYyTTLISFTDTVKQHHTKHQRGHTelsqslFPLLLSpvCSAGVGRTGTFICLYNMLDMMKEE--GRVDIFSFISKMRENRIKMVQTKEQYIFLYN
 |.  . .. |  . ..   |... .        |...   || | | || |..|   .   .|     ||.|    ..|. |  .. . ..| |.|.
tpnv.alfvgfvvasrevskkyeqekd......apvivh..csdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 66-258 5e-12 40.4 In-house 10-197 (198) alignment 
Range on Protein: 66-258
Range on HMM: 10-197/198.0
SAPNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDFSLFLLEVEQFSDHIVRTLIVKKKES--EEKRTIVQYHYLSWPDMGV
  |   .|. ||.|.|.     |||| .     .     |||    ..  .| .|.    .   .|. . .||. .. .     | | .| . || .   
qhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkektt

PEYyTTLISFTDTVKQHHTKHQRGHTelsqslFPLLLSpvCSAGVGRTGTFICLYNMLDMMKEE--GRVDIFSFISKMRENRIKMVQTKEQYIFLYN
|.  . .. |  . ..   |... .        |...   || | | || |..|   .   .|     ||.|    ..|. |  .. . ..| |.|.
pnv.alfvgfvvasrevskkyeqekd......apvivh..csdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 374-538 6.6e-12 39.9 In-house 43-211 (263) alignment 
Range on Protein: 374-538
Range on HMM: 43-211/263.0
LPNTVEDLWRLAFDWKCPVIVMLNELDEE---TCVQYWPEEG--SIALETLEVTALDSEStmNFVKRRFTVTSDSG---ESMTVEQFEMLGWgMSHNKPD
| .|.. ...     |  |.||| .  ||    | .|.| |      |. ..|.. .. |  . ...   ..|  |   .  ||...   || . .| | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgW.iekndpe

SPVSLLGLIEAVQGSiKtatckgPAIVHCVNGIGRSGVFCALWSVME----KLRKDNTI--DIFQAVKRLRSSRPNMVE
 . . | .......| |      . .||| .|||||  |    .|       |.. .|.  |  . .. |||||.  ..
lareilnilkvarns.k......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraih
subfamily_hpo-7_pd Subfamily hpo-7 73-282 1e-11 39.3 In-house 47-246 (263) alignment 
Range on Protein: 73-282
Range on HMM: 47-246/263.0
LTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDFSLFLLEVEQfsDHIVRTLIVKKKES--EEKRTIVQYHYLSWPDMGVPEYYTTL
. .|...| | .  ..||...  |.|...| .|.| .     .. . ..   .| .  | ...|| . .  .   . .|. .| |  |..   ||     
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

ISFTDTVKQhhtkhqrghtelSQSlfpllLSPVCSAGVGRTGTFIC---LYN-MLDMMK--EEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLEVY
.   . ...            |.|     |  .||.|.||.  |     .|  |.  ..  . . .|  |.. ..|..| . ..|  |  |    .|.. 
lnilkvarn............sks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

LSGKTEIPVS-KFREKMDT
|   ..  .. |..|   .
lnnfakgeleakyqeirks
subfamily_CG42327_pd Subfamily CG42327 292-412 1.7e-11 38.3 In-house 4-122 (319) alignment 
Range on Protein: 292-412
Range on HMM: 4-122/319.0
KANIHVEFKNLHTLTPTPSansfrsGRASINRKKNRFPDILPLERNRPYLACPGSIGSTDYINASFLNTFQKK-DVFLATQSPLPNTVEDLWRLAFDWKC
. ..  ||..|  |                 ..|.|. ...||   |. |   |.  .. |..||..  ...    ..|.| .| ..  |.||. .. . 
redvaeefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqs

PVIVMLNELDEET---CVQYWPEEG
 ||| | .| |     | .|.| . 
rvivqltdlselGikvcaeylPtke
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 365-538 1.7e-11 38.7 In-house 5-188 (199) alignment 
Range on Protein: 365-538
Range on HMM: 5-188/199.0
DVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEET---CVQYWPE--EGSIALETLEVTALDSESTMNFVKRRFTVTSDSGESM---TVEQFEMLG
  ..||| || .|. |.|.. ..     |||.|. . .       |||    |.    .| ||.    .  ...   . .|...        . ....  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WgmsHNKPDSPVSL-LGLIEAVQG-SIKTAT-CKGPAIVHCVNGIGRSGVFCALWSVME--KLRKDNTIDIFQAVKRLRSSRPNMVE
|   ..|    |.| .|.. | .  | |       | |||| .| | .||| ||   .   .  |   .|.|.  |||| .|  .. 
w...kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 366-538 1.8e-11 38.6 In-house 5-187 (198) alignment 
Range on Protein: 366-538
Range on HMM: 5-187/198.0
VFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEET---CVQYWPE--EGSIALETLEVTALDSESTMNFVKRRFTVTSDSGESM---TVEQFEMLGW
 ..||| || .|. |.|.. ..     |||.|. . .       |||    |.    .| ||.    .  ...   . .|...        . ....  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

gmsHNKPDSPVSL-LGLIEAVQG-SIKTAT-CKGPAIVHCVNGIGRSGVFCALWSVME--KLRKDNTIDIFQAVKRLRSSRPNMVE
   ..|    |.| .|.. | .  | |       | |||| .| | .||| ||   .   .  |   .|.|.  |||| .|  .. 
...kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 12-108 6.2e-11 36.2 In-house 47-155 (349) alignment 
Range on Protein: 12-108
Range on HMM: 47-155/349.0
KNKPKNRFRNIIAYDHSRVVLEKVD--------------GDPHSDYFNANYLSVSIYRIQNicLFFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEA
.   |||...|. |.||||.|.|                .    || |||||... . ...   .    ||  ...  |...|  ..|  .. ...  | 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek..kyiatqaPlPstvddfykvillngvklvlsLnddkel

GKDRCRQYWPK
. ..| .|| .
slekcdiywqe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 144-262 8.6e-11 35.7 In-house 214-342 (349) alignment 
Range on Protein: 144-262
Range on HMM: 214-342/349.0
SEEKRTIVQYHYLSWPDMGVPEYYTTLISFTDtVKQHHTKHQRGHTELSQSLFPLLLSpVCSAGVGRTGTFICLYNMLD---MMK-EEGRVD--------
.|.   ..|  .  |.|...     ...   . ||..    .  .  | ..  . ||   |||| ||||... |  .|.   ... |  ...        
vekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllv.hcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDl

IFSFISKMRENRIKMVQTKEQYIFLYNALLE
|.  . ..|  || |||   |.|..|.|||.
isiivnelrkqrismvqnlaqfiaiyealLk
subfamily_CG42327_pd Subfamily CG42327 203-261 1.6e-10 35.1 In-house 253-312 (319) alignment 
Range on Protein: 203-261
Range on HMM: 253-312/319.0
VCSAGVGRTGTFICLYNMLDMMKEE-GRVDIFSFISKMRENRIKMVQTKEQYIFLYNALL
 || ||||||. |     .  ..|    |||   .| .|..| . |.||||| |.|. | 
hcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 203-262 2e-10 35.0 In-house 234-293 (297) alignment 
Range on Protein: 203-262
Range on HMM: 234-293/297.0
VCSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE
 |||||||.|  .    .|.... .   |. ...|..||.| ..||| ||. .||.| |.
hcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 491-537 1.4e-09 32.2 In-house 2-48 (69) alignment 
Range on Protein: 491-537
Range on HMM: 2-48/69.0
IVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMV
.|||  | ||.| | |.   | ... .  .|||  |. .|  || ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 491-537 2.2e-09 31.5 In-house 1-47 (69) alignment 
Range on Protein: 491-537
Range on HMM: 1-47/69.0
IVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMV
.|||  | ||.| | |.   | ... .  .|||  |. .|  || ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 349-410 3.2e-09 30.6 In-house 89-155 (349) alignment 
Range on Protein: 349-410
Range on HMM: 89-155/349.0
STDYINASFLN--TFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEET---CVQYWPE
  ||||| .|.   .. .  ..||| ||| ||.| ...    . .... ||. .|..   | .|| |
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 349-446 4.2e-09 30.8 In-house 12-109 (130) alignment 
Range on Protein: 349-446
Range on HMM: 12-109/130.0
STDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEETcvQYWPEEGSIA--LETLEVTALDSESTMNFVKRRFTVTSDSGES
  .||||||.   ..   .| || || .|  |.|.. ..    |.|.|  ..||   .|||.   .    | . ||  | .   |     . . ||  ||
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed..eywpdsePlewyeediivtltdrdefknikasnleiesdlnes
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 288-534 1.4e-08 28.7 In-house 16-259 (303) alignment 
Range on Protein: 288-534
Range on HMM: 16-259/303.0
SVTKKANIHV-EFKNLHTLTP-TPSANSFRSgrasiNRKKNRFPDILPLERNRPYLAcpgsigSTDYINASFLNTFQKKDVFLaTQSPLPNTVEDLWRLA
 . . ||| | ||... .  | . | | | .     | .|||| |.. |.  .  |.       . || ||.|.   .|   | || ||. |  |.|.. 
tldedaniavnefekvvsylppsvsknqfvk.....nmdknrfvdvicldhskvkls......dssyihasyleldsskkail.tqlplshtaadfwqmi

FDWK--CPVIVML-NELDEETCVQYWPEEGS-IALET--LEVTALDSESTMNFVKRRFTVTSDSGESMTVEQFEMLGWGMSHNKPDSPVSLLGLIEAVQG
 . |  | ....  .| |.      .|..   . .|   . |  .     ..  . .    |.      .       |  .    |.   ..  |  .| 
ieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqs

SIKTATCKGPAIVHCVNGIGRSGVFCALWSVMEKLR-KDNTIDIFQAVKRLRSSRP
 ..  .   |..   . | ||.| |. . .    |  .....|. . .. .|  | 
vlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrl
subfamily_eak_pd Subfamily eak 302-458 1.5e-08 28.4 In-house 32-190 (332) alignment 
Range on Protein: 302-458
Range on HMM: 32-190/332.0
LHTLTPTPSANSFRSGRASINRKKNrFPDILPLERNRPYLAcPGSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNE---
.. |     . | . ..   . ..|   .|.| .|.   |. .       ||||| ..  .    .. |  .  . |  .|.. .. | | ||.| |   
vadlddyqrllsisetarleavnrn.vvkivpydrylvrlt.ssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve

LDEETCVQYWPEEG--SIALETLEVTALDSESTMNFVKRRFTVtSDSGESMTVEQFEMLGWG
|. |   .|.|...   .    |.|.  .     ..  | . . |   |.  |  ... || 
lkleksdkyfpdktreelkfGildverkefvkrniletrllel.skGnethrvlhykvfGwt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 488-540 2.3e-08 28.3 In-house 229-281 (297) alignment 
Range on Protein: 488-540
Range on HMM: 229-281/297.0
GPAIVHCVNGIGRSGVFCALWSVMEKLRKDNTIDIFQAVKRLRSSRPNMVETL
 . .|||  |.|||||      ...||||.   |.   .. ||. |. .|.||
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-49 3.2e-08 27.6 In-house 38-81 (95) alignment 
Range on Protein: 3-49
Range on HMM: 38-81/95.0
SPWEVASKEKNKPKNRFRNIIAYDHSRVVLEKvdgDPHSDYFNANYL
.|. | | | | ||||| ||. || .||||        ||| || ..
apytvgsseanipknrflnifpydatrvvltt...krdsdyinacfv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 289-371 3.5e-08 27.5 In-house 15-94 (95) alignment 
Range on Protein: 289-371
Range on HMM: 15-94/95.0
VTKKANIHVEFKNLHTLTPTPSANSFRSGRASINRKKNRFPDILPLERNRPYLACpgsIGSTDYINASFLNTFQKKDVFLATQ
.  ..|   || |     .  |  ..  | .  |  |||| .|.| .  |  |.       .||||| |.. . .|....|.|
lemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 62-144 3.8e-08 27.1 In-house 238-316 (440) alignment 
Range on Protein: 62-144
Range on HMM: 238-316/440.0
FFVSSAPNTASLTAFWRMIWQENVATIVMVTNLIEagkDRCRQYWPKNPRSVeVMGDFSLFLLEVEQFSDHIVRTLIVKKKES
|  .  |  ...  |||.. . ...||.|. .| .     |  ||| | |||  .| |..     |..    |||| .| || 
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsv.tfgpftvghkgsenmnrvkvrtlelkykee
subfamily_CG42327_pd Subfamily CG42327 483-539 6e-08 26.7 In-house 243-300 (319) alignment 
Range on Protein: 483-539
Range on HMM: 243-300/319.0
TATCKGPAIVHCVNGIGRSGVFCALWSVMEKLRKD-NTIDIFQAVKRLRSSRPNMVET
|   .|| .||| .|.||.|.  |    ...| .  ...|| | |  .|  | . | |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 67-178 7e-08 26.3 In-house 98-221 (302) alignment 
Range on Protein: 67-178
Range on HMM: 98-221/302.0
APNTASLTAFWRMIWQENVATIVMVTNLIEAGKDRCRQYWPKNPRSVEVMGDFSLFLLEV----EQFSDHIVR---TLIV--KKKESEEKRTIVQYHYLS
 |   .|  .| .| | ||| .| .....| .. .| .|. .. . .  .| ...  ..|    |.|.|       |. .  .||... |.|.   .. .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDMGVPEYYT---TLISFTDTVK
||| | |.       .. | .. |
wpdhGapkeaytaldilkfcesyk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 204-257 2.7e-07 24.4 In-house 228-281 (302) alignment 
Range on Protein: 204-257
Range on HMM: 228-281/302.0
CSAGVGRTGTFICLYNMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLY
||||||||||.. .   ... ...   |. | .  .|. |   ||...| |.| 
csaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 11-108 4.6e-07 22.9 In-house 25-86 (169) alignment 
Range on Protein: 11-108
Range on HMM: 25-86/169.0
EKNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNAnylsvsiyriqniclffvssapntasltafwRMIWQENVATIVMVTNlieagKDRCRQYWPK
  |. |||    .|  | || |..|  |  ||| ||                               ||||. | . ||.. .      |   ..||.
tcnetknrpagplapshtrvklqrvmedlgsdyina...............................rmiwetnasvivvlgd.....tddknnfwpe
0038934 (Phosphotyrosine protein) phosphatases II 484-538 5.4e-07 25.0 In-house 112-161 (194) alignment 
Range on Protein: 484-538
Range on HMM: 112-161/194.0
ATCKGPAIVHCVNGIGRSGVFCALWsvmekLRKDNTIDIFQAVKRLRSSRPNMVE
.  .|   |||. |.||.|...| .     | . . ..  .|....|. ||....
edpggvvaVHCkaGlgRtGtlvaaY.....LiyrlgmsaeeAialfrekRpgaip
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 12-108 5.5e-07 22.6 In-house 25-85 (169) alignment 
Range on Protein: 12-108
Range on HMM: 25-85/169.0
KNKPKNRFRNIIAYDHSRVVLEKVDGDPHSDYFNAnylsvsiyriqniclffvssapntasltafwRMIWQENVATIVMVTNlieagKDRCRQYWPK
 |. |||    .|  | || |..|  |  ||| ||                               ||||. | . ||.. .      |   ..||.
cnetknrpagplapshtrvklqrvmedlgsdyina...............................rmiwetnasvivvlGd.....tddknnfwpe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 438-515 9.7e-07 22.8 In-house 206-290 (350) alignment 
Range on Protein: 438-515
Range on HMM: 206-290/350.0
TVTSDSGESMTVEQFEMLGWGMS--HNKPDSPVSLLG----LIEAVQGSIKTATCKGP-AIVHCVNGIGRSGVFCALWSVMEKLR
 .|  . . . | |. .  |  .   ..| | .. |     ||.         . ...  .|||  |.|| |....| |..... 
aitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 350-402 2.2e-06 21.4 In-house 70-122 (347) alignment 
Range on Protein: 350-402
Range on HMM: 70-122/347.0
TDYINASFLNTFQKKDVFLATQSPLPNTVEDLWRLAFDWKCPVIVMLNELDEE
  ||||| ..  . .  .. || |||.|| |.|.. .  |   .| . |  ..
etyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 398-521 3.5e-06 20.7 In-house 144-269 (332) alignment 
Range on Protein: 398-521
Range on HMM: 144-269/332.0
ELDEETCVQYWPEEGSI-ALETLEVTALDSESTMNFVKRRFTVTSDSGESMTVEqFEMLGWGMSHNKPDSPVSLLGLI--EAVQGSIKTATCKGPAIVHC
||  . | ..|||..|   . .| . | |  |   .    .|||    .  ||  . .  |  . . |.  . .   |  . .. | ||  | || .. |
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvl.mhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvc

VNGIGRSGVFCALWSVMEKLRKDNTID
  |. .  .....  .. .. ..  . 
atgvekcaisatidiivsriteehrvg
subfamily_DSP1_pd Subfamily DSP1 483-536 3.9e-06 21.0 In-house 91-143 (163) alignment 
Range on Protein: 483-536
Range on HMM: 91-143/163.0
TATCKGPAIVHCVNGIGRSGVFCALWsVMEKlRKDNTIDIFQAVKRLRS-SRPNM
  ...|  ..||  || ||  .| .. .|.. .. .  . |. ||. || ..||.
vkkknGkvlihCqaGisRsstlclay.lmkt.krvsleeafdfvkqrRsiisPna
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 322-402 4e-06 20.5 In-house 34-113 (332) alignment 
Range on Protein: 322-402
Range on HMM: 34-113/332.0
NRKKNRFPDILPLERNRPYLACpgSIGSTDYINASFLNTFQKKDVFLATQSPLPNTVED-LWRLAFDWKCPVIVMLNELDEE
|   || | .  ....|  ||     |  |. |||... . ||  .. .|.|. .  |  .||.  . |  .|... ..||.
nmdmnriphlycfdhsrvelap..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_ptpA1_pd Subfamily ptpA1 219-264 7.3e-06 20.0 In-house 353-399 (418) alignment 
Range on Protein: 219-264
Range on HMM: 353-399/418.0
NMLDMMKEEGRVDIFSFISKMRENRIKMVQTKEQYIFLYNALLE-VY
 ..|  .    ...|| . |.||.|  |||  |||.| |...|. .|
aimdkynsridfnlfsivlklreqrpgmvqqleqylfcyktildeiy
subfamily_PTPDC1_pd Subfamily PTPDC1 203-256 8.4e-06 20.3 In-house 120-168 (182) alignment 
Range on Protein: 203-256
Range on HMM: 120-168/182.0
VCSAGVGRTGTFICLYNMLDMmkeegRVDIFSFISKMRENRIKMVQTKEQYIFL
 | || ||||  |. | .        |..    |...|..| | .||.||  ..
hChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelv