Gene SpurPTP-sf4-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP104_AA protein Get Run
SpurP104_AA_265-537 phosphatase_domain Get Run
SpurP104_AA_549-668 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 258-572 1.6e-211 695.8 In-house 1-315 (315) alignment 
Range on Protein: 258-572
Range on HMM: 1-315/315.0
NAHQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||..|||||||||
nahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgp

NVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
||||||||||.|.|||.||||||||.|||||||.||||||||.||||||||||||||||.|||||.|||||||||||||.||||||||||||||.||||.
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnl

IRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLA
||||||||||||||||||||||||||||||||||.||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||.||||
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydslla

PSPDTGSTLLQEQFE
|||||||||||||||
pspdtgstllqeqfe
subfamily_PTPRD_pd Subfamily PTPRD 260-668 2.5e-156 516.6 In-house 2-413 (564) alignment 
Range on Protein: 260-668
Range on HMM: 2-413/564.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNV
..||| ..| ..||. ||. .  |...|..|  || .. ..|.| .||.|||| ||.||||||| |  .|.|. |||.||.|||||. .. |||.|||  
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK-KMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMN
 ...||||||||...  |||||...| .| ||.||||.| .  ||..||| ..||  ..|..|||..     .. ||| |||.||||| |||...|.|..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLL
.||.|......  | ||||||||||||||||..||||.....|. .|.|.... .|..|  |||  |||.||..|.||   ||.|..  . . |.   | 
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

APSPDTGSTLLQEQFERLDmFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRL
  ..||..| |.  |.||   . .   .|  .| .. | .|||. . |.....|  | ..  .....|||||.| .| .|  |. ||.|| ||| ||||.
eveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwrm

VFDYKISTIIMLN
|..... .|.||.
vweeevkiivmlt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 263-574 3.1e-105 346.7 In-house 2-318 (318) alignment 
Range on Protein: 263-574
Range on HMM: 2-318/318.0
IPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDV-AKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVAS
|....| . |.. ..| .  ....|| .   . ..  . . .  ||.||||.||.||||.||.|  ||... |||.|||.||||.  . |||||.|    
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
..|||||||| ..  |||||...|  |.|...|||.|. . |||..|. |.|   ..|..|.|.|     .. |.| |.||||||| |||. .. |....
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RTVKQHH-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLA
|.|.. . ....|.|||||||||||||.||..|..|....||. .||..... .|..|  |||. .||.||||.|||   .||| .  .   .|   |  
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

PSPDTGSTLLQEQFERL
..|..| | .. .|.||
qdpesgttemdaefqrl
subfamily_PTPRK_pd Subfamily PTPRK 266-572 1.6e-102 337.5 In-house 7-313 (314) alignment 
Range on Protein: 266-572
Range on HMM: 7-313/314.0
DQLITYVAQKKASTKNGFKQDYESIPGGqlhpLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDF
. |.  .|. |..   |||..|||.. |     |.||| ||..|||. .|.|||.|||.|  ...||.|||.||..||.|. |. .|..|||    ||||
adllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdf

WRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVVF----GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTV
||.|..|.|  |||||. ||  . || ||||.. ..||.| |.  . |... . ||.|.|       ..|||| ||....||| .||.. | |....| |
WrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLAPSPD
|... .. | |||||||| |||||||..| .|| .| |. .||.| .  .|.... ||.. |||.||||..||. .||.|.|    .   | . .   |.
kksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpq

TGSTLLQEQFE
| |. |.|.|.
tnssqlkeefq
subfamily_PTPRA_pd Subfamily PTPRA 258-544 9.6e-101 332.0 In-house 9-303 (330) alignment 
Range on Protein: 258-544
Range on HMM: 9-303/330.0
NAHQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLH-PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQG
. . |.|...|   . ...|   . |.......| |...  |..|.| |||.|||..||. ||.||| |. .|  ..|||.|| |||||.   ..|||||
kkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

PNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVV-FGDNI-----REVVQFHYTSWPDMGVPK
|   .|.|||||.|| .   |||||.  | .. ||..||||.  . ||.|.|. . |.|  .|||| | |   .|.      | | |||.|||||.||| 
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

YTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIA
 .  ...... ||. . .| |.||||||||||||||||.|||.|.. .||. .||..|.  .|..| .|||  |||.||| .||| .. ||| . 
epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld
0051299 (Phosphotyrosine protein) phosphatases II 260-536 1.8e-100 331.3 In-house 2-286 (288) alignment 
Range on Protein: 260-536
Range on HMM: 2-286/288.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLH-PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPN
. .|....|. .| ...|. ..|... .| ..  . . .| .|.. ||..|||| .|..||||||.|  |.....|||.||..|||||..|..||.||| 
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

VASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVV------FGDNIREVVQFHYTSWPDMGVPKYT
  .|.||||||||...  |||||..|| ...||..||| .....||.|||| .||||. .|||||. |.      .... |.| .||||.|||.||| ..
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
..|..|.| |.... .. | .|||||||||||||||.|| .|.| |.|. .||....  .|. |  |||  |||.|.|.|||| .
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 260-571 3.1e-100 330.3 In-house 2-318 (319) alignment 
Range on Protein: 260-571
Range on HMM: 2-318/319.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNV
...|....| ... . ............. . ...   .| |.| |||.|||| ||.|||..||.|. |.. . |||.||.|||||.  ...||.|.|  
dteievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVVF-GDNI--REVVQFHYTSWPDMGVPKYTTPLM
  ..|||||||||..  .||||. ||  | |..||||... . ||...|| ..||   .| .| ...    ...  |||..|.||.||| .||...| |.
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

NFIRTVKQHHTN-SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPS
.... ... . . . | ||||||||||||||||.|||||.. . |...||....  .|  |  |||  |||.|||.||||   .||| |  .   .|  .
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LLAPSPDTGSTLLQEQF
|    .||| | |. .|
laekvadtgetgleref
subfamily_PTPRB_pd Subfamily PTPRB 259-536 1.4e-99 327.9 In-house 3-285 (293) alignment 
Range on Protein: 259-536
Range on HMM: 3-285/293.0
AHQPIPLDQLITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGP
 ..|| |... ..|...|| .. .|...||..   |. .  ..|.. .|..|||| ||..||||||.|  |.....|||.|||.|.||| || .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

NVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK--KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLM
   .|.||||||||. .  |||||..||. | |||.|||..   ..||.|.|| ..||. .....|....  ....|.| |.|.||||| |||. |..|.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

NFIRTVKQHH--TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
.|.|||....  |.| . ||||||||||||||||.|| .|.. | |. .|.. ... .|..|  .||  .|| ||....|. .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0050432 (Phosphotyrosine protein) phosphatases II 260-539 2.4e-98 324.6 In-house 23-302 (308) alignment 
Range on Protein: 260-539
Range on HMM: 23-302/308.0
HQPIPLDQLITYVAQkkASTKNGFKQDYESIPGGQL-HPLDVAKKIENKQKNRYINIIAYDHSRVQLpllenDPHSDYVNANFIDGY--NYPRRYIAAQG
. ......|. .. .  |  . .... .| ..  .  .. .||.. ||| |||| .|..|||||| |     |..|||.||...|||  ..||..||.||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD----KKMIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKY
|   .|.||||||||...  |||||..|| .. ||..|||.    . ..|||.||| .||||. .|||||. ...  ... |.| .||||.|||.||| .
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

TTPLMNFIRTVKQHHTNsvGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCG
...|..|.. |.... .  | ||||||||||||||||.|| .|.| |.|. .||.. .  .|. |  |||  |||.|.|.|||| . . 
peilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0040438 (Phosphotyrosine protein) phosphatases II 269-571 1.1e-96 319.1 In-house 6-311 (317) alignment 
Range on Protein: 269-571
Range on HMM: 6-311/317.0
ITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRM
. .. . ..| ...... .| ..  .|.. .||.. |||.|||| .|. ||||||.|  |..|..|||.||...||.|..|..||.|||   .| |||||
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

VWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH
|||.... |||||...| ...||..||| .... ||..||| .|||.. ..|.||. |.   ... |.| .||||.|||.|||.....| .|.. |... 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLAPSPDTGST
 .. | ..||||||||||||||... ||.| | |. .||.. .  .|. | ..||  |||.|.|||||| . ...|..    .  ... ||.| . ....
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk

LLQEQF
| ....
lkekel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 269-534 1.6e-96 317.7 In-house 9-277 (288) alignment 
Range on Protein: 269-534
Range on HMM: 9-277/288.0
ITYVAQKKASTKNGFKQDYESI-PGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWR
...||.|.|....||...|.|. . .. .  ..... .|..|||| ||..||. ||.|  ||. . .||.||..|||..  ..|||.|||. ..|.|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKM--IYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH
.|.|..   |||||. |||.|.|||.||||..    ||..||| ....  .....|.. ..   . .|. |..|..|||.|||. ..||....|.||. .
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan

TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.. .| |.||||||||||||||.|||..|. |.|. ||| .... .|..|  .||. .||.|||..||.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 261-548 2.8e-96 317.2 In-house 2-295 (305) alignment 
Range on Protein: 261-548
Range on HMM: 2-295/305.0
QPIPLDQLITYVAQKKASTKNGFKQDYESIPGGqLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
..| ||.| .|. .... ...|....|.|..    ...|| || .||.|||. .|. .|..|..|   |....|||.||...|||.   .||.||||   
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMI---YGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPL
 |.||||...||   .|||||..|||.| ||..|||..|     .|...|. |||.  . |. | ... .    .. | |.|.. |.||| |||...| |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

MNFIRTVKQHHTNSVG-AIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLY
...|. |.... .. | ...|||||||||||.||..| .|.....|. .||.. .  .|..|.||||  .||.|..||| |   ||||||  . .
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
0046845 (Phosphotyrosine protein) phosphatases II 283-540 3.1e-95 314.1 In-house 2-278 (284) alignment 
Range on Protein: 283-540
Range on HMM: 2-278/284.0
FKQDYESIPGGQLH---PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEND-PHSDYVNANFIDGY-----NYPRRYIAAQGPNVASVKDFWRMVWEED
.....| ..  . .   .|.||.. ||. |||| .|..|||||| |  |..| ..|||.||...|||     ......||.|||   .|.||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CGKIVMLTNTVEGEKRKCEKYWP--DKKMIYGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHT--
.  |||||..|| .. ||..|||  .....||..||| .||||. .|||||.....   ... |.| .||||||||.||| ....|..|.|.|.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

NSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAEN---AIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGD
.. | ||||||||||||||||.|| .|.| |.|.    .||.. .  .|. |  |||  |||.|.|.|||| . .. 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 268-543 7e-95 312.7 In-house 14-297 (298) alignment 
Range on Protein: 268-543
Range on HMM: 14-297/298.0
LITYVAQKKASTKNGFKQDYESIPGGQL----HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVK
|  ..| ||. .  |...... .  ..     .  .||.| |||.|||| .|||.|.||| |   ..| .|||.|| |...|.    .||.|.| ...|.
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD-KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRT
||||||.||| | ||||||..| .| |..||||| .|  ||.|||. .|.|. . ..||.. |   .  . |||.|.|.||||| |||...| .....| 
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

VKQhHTNSVG--AIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSI
|.. ...  |  ...|.|||||||.|||| .|..|.....|. .||.. .  .|..|...||  ||| |||.| || . .... |
vra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPRG_pd Subfamily PTPRG 263-545 1.9e-94 311.9 In-house 1-296 (563) alignment 
Range on Protein: 263-545
Range on HMM: 1-296/563.0
IPLDQLITYVAQKKASTKNGFKQDYESIPGG---QLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPH-SDYVNANFIDGYNYPRRYIAAQGPN
.|....  .||. .|... ||....|..      .  . . ..| |||.||||.||.|||.|||.|  | .  .  ||.|||.||||.  . .||.||| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

VASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVVF--------GDNIREVVQFHYTSWPDMGVPK
   ..|||||.||.    |||.|| || ..|||. ||| |. . ||...|| ..||| . |||||...           |. ..| |.|||.|||.|||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQ
...| ..|..  .. . . .| ||||||||||||||.| ||..| | ..|||..|..|.  .| .|  .||  |||.|..|||||.   ..| . .
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
0043336 (Phosphotyrosine protein) phosphatases II 262-534 1.4e-93 308.6 In-house 1-275 (278) alignment 
Range on Protein: 262-534
Range on HMM: 1-275/278.0
PIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVAS
||.  .|. ........ | ......|...  .| . ..|...|||.|||| .|..||||||.| ||..|..|||.||...||||.||..||.|||.  .
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIR
|.||||||||...  |||||. || .. || .|||.. . ||..||| ..||.. .|||||. |.    .. |.|...||..|||.|||  ...|..|..
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

TVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.|...  .| |...||||||||||||||.|. .|.|.| |  .|... .  .|. | ..||  .||.|.|.||||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 281-541 2.8e-93 307.7 In-house 13-282 (297) alignment 
Range on Protein: 281-541
Range on HMM: 13-282/297.0
NGFKQDYESIPGGQ-LHPLDVAKKIENKQKNRYINIIAYDHSRVQLplleNDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVM
..... .|...  . | .|.||.. ||..|||| .|..|||.||.|    .|..|||.||...|||...|..||.|||   .| ||||||||...  |||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEV--NTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN--SVG
||. || .. ||..|||   .. . ||..||| .|.||  ...||.||. |..  ... |.| .||||.|||.||| ....|..||. |.... .  | |
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

AIVVHCSAGVGRTGTFITLDAMLDQAE---AENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDT
 ..|||||||||.||||..| ||.| |    |. .|.....  .|. |  .||  |||.|.|.|||| . ...|
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 275-534 3.1e-93 307.5 In-house 6-270 (273) alignment 
Range on Protein: 275-534
Range on HMM: 6-270/273.0
KKASTKNGFKQDYESIPGGQL-HPLDVAKKIENKQKNRYINIIAYDHSRVQLplleNDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEED
.|.. ...... .| ..  .  ..  ||...|||.|||| .|..|||||| |    .|..|||.||...||||..|..||.|||   .|.||||||||..
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

CGKIVMLTNTVEGEKRKCEKYWPDK----KMIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN
.  |||||..|| ...||..|||..    ...|||.||| .|||.. .|||||. ...   .. |.| .||||.|||.||| ....|..||. |.... .
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
  | | .|||||||||||||||.|| .||| |.|. .||.. .  .|. |  |||  |||.|.|.||||
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 260-538 2.8e-92 304.6 In-house 11-291 (297) alignment 
Range on Protein: 260-538
Range on HMM: 11-291/297.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHpLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEN-DPHSDYVNANFIDGYNY-PRRYIAAQGP
. ||||. |  ..  .||. |.......|...  .     .|...||| ||||..|..||||||.|  ... |..|||.||...|||.. .|..||.|||
sipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

NVASVKDFWRMVWEEDCGKIVMLTNTVEGEKrKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
.  .|.||||||||...  |||||..|| .. ||..|||..   ||..||| ...|.. .|||||..|. ..  |.| .|.||.|||.||| ... |..|
lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef

IRTVKQHHTN--SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
.. |.... .  . | ..||||||||||||||... ||.| | |  .||.. .  .|. | ..||  .||.|.|||||| . .
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 262-589 2e-91 301.7 In-house 1-329 (515) alignment 
Range on Protein: 262-589
Range on HMM: 1-329/515.0
PIPLDQLITYVAQKKASTKngFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVAS
|.|| |. ..|....  |   | ...  .|| ...|  ||..  | .|||| ||. || .||.| .....|||||.|| .| ...  . |||.|||| ||
plplaqfPafvnknrhttl..fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

VKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
|.||||.|..|.   |.|.|.  ||.| || |||||   . . .|.| |   | |  |  . |.. |. ||..| | |||.| ||| |||| |. |. .|
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllkli

RTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLAP
. ||  | .   ....|||||||||| .|..| .. .|.  ...||.||.| .||.| ..||  ||| |||.|.|| .   .| |    . .    | . 
kevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhss

SPDTGSTLLQEQFERLDMFTIKPRDDELRTA
    | . . ..|. |  ..  |   . |..
gdgrgrskmtkefqtlkslcpdppasqtrsg
0045450 (Phosphotyrosine protein) phosphatases II 257-536 2.9e-91 301.7 In-house 3-304 (307) alignment 
Range on Protein: 257-536
Range on HMM: 3-304/307.0
ENAHQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLH---PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEND-PHSDYVNANFI--------DG
 . ...|.. .|. .|...... ..|... .|...  . .   . ..|.. ||| |||| .|..|||.||.|  |... ..|||.||...        ||
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK--KMIYGKITVTRKSEEVNTHYTVRTFSVV---FGDNIREVVQFHY
|. .|..||.|||   .|.|||||.||.... |||||..|| ...|| .||||.  .. ||..||| .|||.  .|||||. |    . .. |.| .|||
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TSWPDMGVPKYTTPLMNFIRTVKQHHTN--SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENA---IDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|.|||.|||... .| .||. |.... .  . | ..||||||||||||||... ||.| |.|.    .|... .  .|. | ..||  |||.|.|.||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

TF
 .
ll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 269-535 4.3e-90 296.6 In-house 3-275 (281) alignment 
Range on Protein: 269-535
Range on HMM: 3-275/281.0
ITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWR
 . ..|.... ..||...||..   |. ..   .|. ||..||||.||.|||..||..   |.. ..||.||||..||. ...|||.|||  ||...||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK--MIYGKITVTRKSEEVNTHYTVRTFSV-VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH
||||..  .|||.|. .|..| || .||||..  ..||..||. ..|| ...|  |.|..   . . |||.|..||.||| |||. |. |..| . |.. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

H-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE-NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
. ...  ..|.|||||||||||.|.|| .....||| . .|| . .. .|..|  |||   ||.|.| |.|..
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Ptp69D_pd Subfamily Ptp69D 262-553 9.9e-90 295.8 In-house 3-303 (307) alignment 
Range on Protein: 262-553
Range on HMM: 3-303/307.0
PIPLDQLITYVAQKKASTKNGFKQDYESIPGGQL-HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
.|..|.| . . ..|  |. |....||...  .  .   |..| ||. |||| .|.|.|. ||.|. .. . .|||.||.|| ||.  ...||||.|  |
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVVFGD-------NIREVVQFHYTSWPDMGVPKYTT
 ..|||||..| .   ||||.|  | ...||.|||| .... ||.| |.  |||  ..|. |...|   .       . |.|||.|||.|.|. ||. ..
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

PLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRY
 |...|. |.... .. . |||||||||||.|.|..|| .|.| .||. .|..... ..|..|  .||  |||.|.| |||..   ||| .. | . ...
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

P
 
e
DSPc_SM00195 295-536 3.2e-88 290.8 In-house 15-262 (263) alignment 
Range on Protein: 295-536
Range on HMM: 15-262/263.0
LHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKY
 .. . |.| .||.|||| ||. |||.||.|.  |....|||.|||.|.|.|....|||.|||    |.|||||||||..  |||||. .| .|.||..|
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

WPDK---KMIYGKITVTRKSEEVNT-HYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFIT
||..   |. .|||.|. ...|    ....||... . .  . |.| |..|..||| |||. |.......|.||... .| | |||||||||||||||.|
wpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
.| .|.. |.|. .|. . .. .|..|..|||  |||.|||.|.|| .
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 295-536 3.2e-88 290.8 In-house 15-262 (263) alignment 
Range on Protein: 295-536
Range on HMM: 15-262/263.0
LHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKY
 .. . |.| .||.|||| ||. |||.||.|.  |....|||.|||.|.|.|....|||.|||    |.|||||||||..  |||||. .| .|.||..|
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

WPDK---KMIYGKITVTRKSEEVNT-HYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFIT
||..   |. .|||.|. ...|    ....||... . .  . |.| |..|..||| |||. |.......|.||... .| | |||||||||||||||.|
wpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
.| .|.. |.|. .|. . .. .|..|..|||  |||.|||.|.|| .
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 261-572 6.7e-88 289.5 In-house 1-313 (315) alignment 
Range on Protein: 261-572
Range on HMM: 1-313/315.0
QPIPLDQLITYVAQKKAStkNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
||||. |. ..| ... .    | ...  .|. . ..  ||.. .| .|||| ||. .|..||.| .....|.|||.|| .| ...  . |||.|||. |
qpipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
||.||||||..|.   |||.|.  ||.| || .||||   . . .|.| |.  | | .|  ..| . .  ... | | ||..| ||| ||.| |. |...
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllkl

IRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLA
|. ||  . .   ...||||||||||| .|..| ...|.. ....||.||.. .|..|...||  |.| |||||.|| .   .| |    . ..   | .
ikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht

PSPDTGSTLLQEQFE
 .  .| . . ..||
svdgsgrskmtkefe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 299-538 8.6e-86 282.2 In-house 2-244 (250) alignment 
Range on Protein: 299-538
Range on HMM: 2-244/250.0
DVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRkCEKYWP-D
.|||| .||.|||| .|||.|.||| |   . | .|||.|| |..||.  . .||.||| .|...||||||.||. | |||||| .| ||  ...||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIRE--VVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN-SVGAIVVHCSAGVGRTGTFITLDAMLD
|  .||..||. .|.|. . ||.|.. .    .  |  |.|.|...||| |||...|  ..... |.. . .   . ..|.|||||||.|.||..||.|.
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
... |. .||...|  .|..|...|.  ||| |.| ..|.  ..
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
Y_phosphatase Protein-tyrosine phosphatase 306-534 1.1e-84 278.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 306-534
Range on HMM: 1-235/235.0
NKQKNRYINIIAYDHSRVQLpllENDPH-SDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMI
||.|||| .|..||..||.|   ..... |||.|||...||. ....||.|||   ...|||||||.|..  |||||. .| ...||..|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKITVTRK-SEE-VNTHYTVRTFSVVFGDNI---REVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
||.|.|. | .|.  ...||.|....   ..    ||| |.|||.||| |||. ...|...|| |....... | .||||||||||||||..||..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|||. .||....  .|..|..||| .|||.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 306-534 1.1e-84 278.9 In-house 1-235 (235) alignment 
Range on Protein: 306-534
Range on HMM: 1-235/235.0
NKQKNRYINIIAYDHSRVQLpllENDPH-SDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMI
||.|||| .|..||..||.|   ..... |||.|||...||. ....||.|||   ...|||||||.|..  |||||. .| ...||..|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKITVTRK-SEE-VNTHYTVRTFSVVFGDNI---REVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
||.|.|. | .|.  ...||.|....   ..    ||| |.|||.||| |||. ...|...|| |....... | .||||||||||||||..||..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|||. .||....  .|..|..||| .|||.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 298-536 4.3e-83 274.0 In-house 3-246 (249) alignment 
Range on Protein: 298-536
Range on HMM: 3-246/249.0
LDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-
 .||.. ||| |||| .|..||||||.|  |.. ..|||.||..||||...||.||.|||   .|.|||||.||.... |||||..|| .. ||..||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DKKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN--SVGAIVVHCSAGVGRTGTFITLDAM
.. . ||..||| .|.||. .|||||. ..    .. |.| ...||.|||.|||... .|..||. |......  . | ..||||||||||||||... |
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
|.| | |. .|... .  .|. | ..||  |||.|.|.|||| .
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 303-546 3.5e-82 271.3 In-house 58-301 (319) alignment 
Range on Protein: 303-546
Range on HMM: 58-301/319.0
KIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTntvegeKRKCEKYWPDKKMI-
  .|| |||.|||.|.|...|.|  |.    |||.|| |..||  . .|||||||   ...|||||.|| .|  ||.||      | || .||| |  | 
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH--TNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
...  |  .| |    |.|| . .       .||.. |||.  |||.|||.|...|| ... |.  .   |    |||||||||||||..|.||..||. 
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQD
. |. .|||||. ..||.| ..||   ||.||| |||| .. | . .|  
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 259-545 3.7e-82 270.8 In-house 6-293 (297) alignment 
Range on Protein: 259-545
Range on HMM: 6-293/297.0
AHQPIPLDQLITYVaQKKASTkNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYprRYIAAQGPN
  .|||| .. |.| ||. .| . |....  .|  ...|  ||.|  | .|.|| ||. || |||.|  ...|| |||||| |. |...  |.|. | |.
errpiplsdfatlv.qknrht.dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

VASVKDFWRMVWEEDCGKIVMLTNTVEGEKrKCEKYWPDKKMI-YGKITVTRKSEEVNTHYTVRTFSVVFGD-NIRE-VVQFHYTSWPDMGVPK--YTTP
 |.|.|||.||..|.   ||||..  |..| || .||.|| .  .|...|. .| .  . .  |...|  |.   |  | |.....|||  |..   .. 
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LMNFIRTVKQHH-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQ
|...|  |.... .|. | ..|||.||||||| ..|.| .. .|. |...|...... .||.| ..||  |||.|.| |.||.... || |  
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
0042113 (Phosphotyrosine protein) phosphatases II 299-534 1.1e-81 269.1 In-house 2-241 (245) alignment 
Range on Protein: 299-534
Range on HMM: 2-241/245.0
DVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-D
.||...|||.|||| .|..|||.||.|.  ..|..|||.||...|||......||.|||   .|.|||||.||...  |||||...| .. ||..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

KKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHT-NSVGAIVVHCSAGVGRTGTFITLDAMLD
 .. ||..||| .|||.. .|||||..|.    |  |||...||..|||.||| ..  | .|.. |...   .| | ..||||||||||||||... ||.
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|.|.|  ..... .  .|. | ..||  .||.|.|.||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 274-533 1.3e-81 269.0 In-house 19-294 (306) alignment 
Range on Protein: 274-533
Range on HMM: 19-294/306.0
QKKASTKNGFKQDYESIP---GGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPlLENDPHSDYVNANFIDG--YNYPRRYIAAQGPNVASVKDFWRM
...  .|.||....|..      .|.  . ..|.|||.|||| ||. .||.|| |   .. | |||.|||.|..   .  ..|||.||   . |.|||||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK--MIYGKITVTRKSEEVNTHYTVRTFSV---VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQ
||.|..  |||.|. ||  | || .||||..    ||||.||  ||. ...|..|..||    .... |||.|.|..|||| |||| .  ...|...|..
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

HHTNSV----GAIVVHCSAGVGRTGTFITLDAMLDQAEA---ENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
.. ..     |.||||||||.||||||| .|..|.. |    .  ||.....  .|. |  .||...||.|.| |. 
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPN12_pd Subfamily PTPN12 296-536 6.1e-81 266.5 In-house 30-277 (290) alignment 
Range on Protein: 296-536
Range on HMM: 30-277/290.0
HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.. ....| ||..|||| .|. ||.|||.|   |....|||.||||| | . . .|||||||  . ..|||||.|| .   .||. . || .| |||.||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PDK---KMIYGKITVTRKSEEVNT-HYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDA
|..   .. .|...|| ..|.  .  ...||. | . .. |.| |||||.||| |||. ...|...|..|.......   .||||||||||||| |..| 
peegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

---MLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
   .| .   .. .||.. .. .|..|  .||  |||...| |..| .
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 305-546 1.1e-80 266.2 In-house 24-265 (284) alignment 
Range on Protein: 305-546
Range on HMM: 24-265/284.0
ENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTntvegeKRKCEKYWPDKKMI-YG
.|| |||...|.|.|...|.|  |     |||.|| || ||  . .|||.|||   ...|||||.|| .|  ||.||      | || .||| |  | ..
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

KITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH--TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEA
.  |  .| |    |.|| . .       .||.. |||.  |||.|||.|...|| ... |.  .   |    |||||||||||||..|.||..||. . 
rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke

ENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQD
|. .|||||. ..||.| ..||   ||.||| |||| .. | . .|  
ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalp
0045098 (Phosphotyrosine protein) phosphatases II 287-539 5.7e-79 260.7 In-house 14-275 (278) alignment 
Range on Protein: 287-539
Range on HMM: 14-275/278.0
YESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQlpllendphsDYVNANFIDGYnyPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEG
.. .. |.     .| ...|. |||| .|..||||||           ||.||..||||  |...||.|||    | |||||.||...  |||||. ||.
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

EKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVV------FGDNIREVVQFHYTSWPDMGVPKYT--TPLMNFIRTVKQHHTN----------
.. ||..|||... ..||..||| .||||. .||.||. |.       ..  |.| ..||..|||.||| ..  ... .... ..... .          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---SVGAIVVHCSAGVGRTGTFITLDAMLDQAeaENAIDVYNFITGMRQNRIK-MVQVAEQYQFIYDALLETFVCG
   | | ..||||||||||||.. .. ||..   |. .|... .. .|. |   .||  |||.|.|..||| . .|
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 266-572 7.1e-79 260.3 In-house 8-324 (325) alignment 
Range on Protein: 266-572
Range on HMM: 8-324/325.0
DQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDF
 .|. .| .|||  ..|| .... .|  .     || | |||.|||. |..|.|.||| |  ...||.|||.||...  .     ..||| |. |...|.
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WRMV--WEedcGKIVMLTNTVEGEKRKCEKYWPDK---KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
||.|  |.     .|...| ....| .| .|||..      .| . |  .. |  . |  | . |  | . . | | ||.. ||.||||.|. . |....
WrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RTVKQHH------TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRY
..||. .      |.. . |.|||||||||||.||.| ..|..   |  .|...|.  .|..| .||. ..|| .||.|| |....|.| .    .  . 
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakl

PSLLAPSPDTGSTLLQEQFE
 ||    | |    ....||
sslqernpltqklniekefe
subfamily_PTPN9_pd Subfamily PTPN9 265-534 3.9e-76 250.9 In-house 3-288 (297) alignment 
Range on Protein: 265-534
Range on HMM: 3-288/297.0
LDQLITYVAQKKastKNGFKQDYESIPGGQLH-PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVK
...|..|| .|.   |.| ...|. |   . .  ....|.  | .|||| ... ||..||.|. ...|..|||.||||.|||. .. .||.|||    |.
ieelvayvkekg...krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
||||||||...  ||| | .||  ..|| .|||   .. . .|...|.. . |.. .|.||.. .     ...|.|. | ..|||| |||. .. |....
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

RTVKQHHTNSVG-------------AIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
..|... . .|               ||||||||.||||||||||  |.. | .. .|| . .  .|. |  ..|. |||.| | |.||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 301-534 4.6e-75 246.8 In-house 2-238 (239) alignment 
Range on Protein: 301-534
Range on HMM: 2-238/239.0
AKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK
|||  || |||| ||..|||||| |  | |||||||.||...  |.  |. |||.||   .|  |||||.|.|    |||||  .|| |.|| .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

MIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAE
  | .. || .  || . | .||| .  |   . | | |.|.| ||| |||.|.| .. . | . .         |.||||||||||.|. .|||| ||.
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

AENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
 ....|..|..  .|..| .||| .||| ||. |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 300-534 5e-75 246.7 In-house 2-239 (239) alignment 
Range on Protein: 300-534
Range on HMM: 2-239/239.0
VAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK
 |||  || |||| ||..|||||| |  | |||||||.||...  |.  |. |||.||   .|  |||||.|.|    |||||  .|| |.|| .|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
   | .. || .  || . | .||| .  |   . | | |.|.| ||| |||.|.| .. . | . .         |.||||||||||.|. .|||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
. ....|..|..  .|..| .||| .||| ||. |.||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
0037934 (Phosphotyrosine protein) phosphatases II 300-534 5.1e-75 247.4 In-house 4-240 (243) alignment 
Range on Protein: 300-534
Range on HMM: 4-240/243.0
VAKKIENKQKNRYINIIAYDHSRVQLpllenDPhSDYVNANFIDGYNyprRYIAAQGPNVASVKD----FWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.|...||. |||| .|..|||||| |     .. |||.|||.|....   |.|| |||   .|.|    ||||.||.... |||||..|| .. ||..||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PDKKmIYGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH--------HTNSVGAIVVHCSAGVGRTG
|...  ||..||| .|||.  .|||||....    .|  |.|...||..|||.|||  ...|..|.. |...        . .| | ..|||||||||||
pgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFITLDAMLDQAeaeNaIDVYNFITGMRQNRIK-MVQVAEQYQFIYDALLE
|.|... ||..    . .|... .  .|. |   .||  .||.|.|.||||
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 263-542 4.4e-74 244.0 In-house 2-284 (287) alignment 
Range on Protein: 263-542
Range on HMM: 2-284/287.0
IPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKI--ENKQKNRYINIIAYDHSRVQLPllenDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
||....  .||. .|  ..|||. .  .   . .. .|  .|  .||.|||. .|. .|  || |     . | ||.|| |||||.  ...|.|..| . 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVVFGD---NIREVVQFHYTSWPDMG-VPKYTTPLM
 ...||......    ||||..  | ....| .|||..| ...|. ...  .||||..|..|.. |   .   . ..|.|...|.|.. | |... | |.
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

NFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTS
 . . .|... .. ..||||||..|||...|.  .  ..... | .|||.. .  .|. . ..|| .|||.||.|..||   ...| 
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 261-544 2.3e-72 238.5 In-house 2-244 (392) alignment 
Range on Protein: 261-544
Range on HMM: 2-244/392.0
QPIPLDQLITYVAQKKASTKngFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
||||  |. ..| ... |.   | ...  .|| ...|  ||.|  |..|||| ||. || .||.| .... |.|||.|| .|....  . |||.||||.|
qpipvaqfpafveknrhsal..ffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

SVKDFWRMVWEEDCGKIVMLTNTVEGEkrkcekywpdkkmiygkitvtrkseevnthytvrtfsvvFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRT
|..||||||..|.   |.|.|.  ||.                                        ||. | | |||.| ||| .|||.|. |..||. 
slddfwrmvfqenvttiamvtklkegd.......................................kgddartvaqfhftewPdkdvpkhtssllkfike

VKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIA
|| .. .    ...||||||||||  |..|... .|.    .||.||.| .|..|  |||. ||| ||| |.|| ..  .| | 
vkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlip
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 263-536 2.2e-71 235.1 In-house 2-283 (290) alignment 
Range on Protein: 263-536
Range on HMM: 2-283/290.0
IPLDQLITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLE--NDPHSDYVNANFIDGYNYPRRYIAAQGPNV
||.|..  .||...|  ..||.......    . |   |.   .||..||. ||. ||  |. |  .   .|   .|.|| .|.||.  ..|||.|||  
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK--KMiYGKITVTRKSEEVNTHYTVRTFSVVFGDN---IREVVQFHYTSWPDMG-VPKYTTP
  ..|||...|.|..  |||||| .| .| || .||||.  |. ||.....  .||. ..|. |...|   ..    ..|.|.. |.|.. | |....| 
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
|. . . .|... .  ..||||||..|||...|....  ..... |  |||.. .  .|. . ..|| ..|||.|.. .|. .
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 301-533 7.4e-71 233.4 In-house 23-265 (274) alignment 
Range on Protein: 301-533
Range on HMM: 23-265/274.0
AKKIENKQKNRYINIIAYDHSRVQL-PLLENDPHSDYVNANFIDGYNYP-RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK
 .   ...|||| .|.  ..||| | .   .|. |.|.|||.| ||..  . |.|.||| .  |.|||||...|.. .|||||.  | ...||..|.||.
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

KMI-----YGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH---HTNSVGAIVVHCSAGVGRTGTFITLD
. .     ||.. .. ..   . .|.||....    . |.|. . ||.|||. .|. ...|..... |..    ... ....|||||||.|||| ||. .
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

AMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
  . | ..|. .|| . .. .|..|  ||| .|||..|. || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 305-534 1.3e-69 229.1 In-house 2-237 (237) alignment 
Range on Protein: 305-534
Range on HMM: 2-237/237.0
ENKQKNRYINIIAYDHSRVQLPLLENDphSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD--KKMI
||| |||| ||.||||||| |    ..  |||.||....|..  |..|||||||  .| .|||.|||.| |  |||||  .||.. || ||||.  .   
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGKITVTRKSEEVNTHYTVRTFSVVFG---DNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTV--KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
||..||. | .|  . ||||.. ..      ..| . |...||||| |||..|. |. | . .  . .| .  |  ..|||||||||| |. .|||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
. .. .|.||..  . ..|  ..|. .|| ||....||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 302-548 1e-67 223.5 In-house 44-291 (439) alignment 
Range on Protein: 302-548
Range on HMM: 44-291/439.0
KKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKrkcekYWP-DKKM
 .  .. |||| .. |.||.|| |  .   ||| |.|||.|.||  .. |||.|||.  ...||||.|.|. . .|||||| ||  |     ||| |...
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev

IYGKITVTRKSEEVNTHYTVRTFSVVF----GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH-HTNSVGAIVVHCSAGVGRTGTFITLDAMLDQ
.|| |.|    .    .|..| | |.     ... | |.||||..|||  ||  .. ...|.|...    .. .| .||||||||||||| |.||  |.|
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLY
  .|| .|.   .. .|..| .|||   || |||.|.||  | ||.... | .
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 288-534 1.7e-67 222.3 In-house 2-262 (270) alignment 
Range on Protein: 288-534
Range on HMM: 2-262/270.0
ESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEG
. .. .. .. |. . . .|. ||| .|.   ..||.|. ||.|... |.|||.. |..  ...||||.||  ...|.||||.|||    |||.|. .| 
keldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

EKRKCEKYWPDK-----KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTT------PLMNFIRTVKQHHTNS--VGAIV
 ..|||.||| .     |. .|||.|.  ||| .. | ..   .    ..|..| |.|..||| |||. .        |.. .|.|......    . ..
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePll

VHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
||||||||||||.|.|| ..   | .. .|| . |. .|..|...||  |||.|.| |..|
vHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN3_pd Subfamily PTPN3 298-535 3.1e-67 221.5 In-house 33-274 (280) alignment 
Range on Protein: 298-535
Range on HMM: 33-274/280.0
LDVAKKIENKQKNRYINIIAYDHSRVQLpllENDPHsDYVNANFI----DGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEK
...|.| || .|||| .|..||. ||.|   .. .  ||.|||..    .. .   ||||.|||   ...|||.||||...  |||||..||  . || .
isaarkpenlsknryrdilpydatrvkl...keset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDK--KMIYGKITVTRKSEEVNTHYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITL
|||..  .. ||...|. ..|. .. | .| . .   .  . |...|. |..||| |||. .. ...|...|.. .. .   .|||||||.|||| .|.|
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
.  |   ||.... . . .  ||. |  .|| |.||.|. .|.|. 
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN1_pd Subfamily PTPN1 296-544 9.3e-66 216.5 In-house 22-281 (290) alignment 
Range on Protein: 296-544
Range on HMM: 22-281/290.0
HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENdphsDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.|  .||. ||...||| ..  |||||..|   .|    ||.||....  .  |.|| .||| .  |. ||.||||...  .||| . || |. || .||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

P----DKKMIYG--KITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH--TNSVGAIVVHCSAGVGRTGT
|    .|....   |..|.  |||.. .||||.. .     .. ||...||||.|||.|||.  . ...|.  |..    .. ||  |.|||||.||.||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FITLDAMLDQAEAE---NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE--TFVCGDTSIA
|. .|..| . |..   ...|. . .  .|. |. ..| |.| .| | |.||   .. ||.|. 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
subfamily_PTPN13_pd Subfamily PTPN13 299-535 6e-64 210.9 In-house 30-268 (273) alignment 
Range on Protein: 299-535
Range on HMM: 30-268/273.0
DVAKKIENKQKNRYINIIAYDHSRVQLpllEND-PhsdYVNANFIDGY--NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.|.|| |||.|||| |.. ||..||.|   ... .   |.||..|     .   .|||.|||   .|||||.|||| ..  |.|.|. .|..| ||..||
evgkkkenkdknryrnvlPydetrvkl...gdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PDKK----MIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTnSVGAIVVHCSAGVGRTGTFITL
|..|    .......|.    .    ..||.. |      . |||.......||| |||. ...|..|.. |.. .| . | ||||||||.||.||.||.
PesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtliti

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
|..|.  | .. .|| . .  .|. |  .||  .|| |.| |.|| 
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_CG7180_pd Subfamily CG7180 275-540 1.1e-60 199.7 In-house 11-294 (296) alignment 
Range on Protein: 275-540
Range on HMM: 11-294/296.0
KKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDC
|.   .  .|. .. .|  .      . . ||..|||..... ||. || |. |. . .|||.|| ..|..  .. ||  ..|   .|..|||.|..|..
krrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeei

GKIVMLTNTVEGEKrKCEKYWPDK-KMIYGKITVTRKSEEVNTHYTVRTFSVVFG------------DNIREVVQFHYTSWPD-MGVPKYTTPLMNFIRT
  .|.||.| . .| .. .||| | |  ||.| |   .|.  .. . ||| ..               . | | .|..| |.    ||  |. |....| 
savvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VKQHHTNS-----VGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGD
|..   .       | .||..| |..|.| ....|| |...| |. .||....  .|..| ..|.  |.|..||| ||| ..|. 
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 273-541 2.7e-59 195.3 In-house 7-298 (301) alignment 
Range on Protein: 273-541
Range on HMM: 7-298/301.0
AQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEN--DPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVW
... |  .|.|...|...  |. .. .|  . |||. ||. ||  ||. |. |   .|    . .|.||..||||.  ...||||||    ..||||..|
thvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

EEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDN-----------------IREVVQFHYTSWPDMGV-PK
.|   .|||.||. || | |||.|||.   ..  .|..||| ..| |   ...| ..|.  |                   ..|.|.. |.||. || . 
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

YTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDT
. | |.     ... .  . | .|||||..|.|.|......  |.|. ||  .||.. .  .|... ..|.  ||| .|||.. ... . .|
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 296-545 5.4e-59 194.4 In-house 23-275 (283) alignment 
Range on Protein: 296-545
Range on HMM: 23-275/283.0
HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENdphsDYVNANFID---GYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCE
 . |.|   |||.|||. .|...|  ||.|  . .    ||.|| ||     |.  ..||.||.|    |.|||.||..|.   |||||.  |... || 
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

KYWPDKKMI-YGKITVTRKSEEVNTHYTVRTFSVVFG---DNIREVVQFHYTSWPDMGVPKYTTPL--MNFIRTVKQHHTNsvGAIVVHCSAGVGRTGTF
.||| .  . ||. ||| . |  .  .... . .       .   .  . .  | ..|       |  .| ... .... .  | ||||||.|.|||..|
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskk..gPivvhCstgiGrtavf

ITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQ
|.. | ...| .|  .||.. .. ||..|. .||  .||...... ||  .|||| || 
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_PTPRN_pd Subfamily PTPRN 277-534 4.6e-57 188.0 In-house 25-290 (297) alignment 
Range on Protein: 277-534
Range on HMM: 25-290/297.0
ASTKNGFKQDYESIPGGQLHPL--DVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNyPR--RYIAAQGPNVASVKDFWRMVWEE
 . |. .....|..   . .|   .|||. .| .|||. ....||||||.|    .. .|||.|| .|   . ||   |||.|||  ..| |||.||||.
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd.prapayiatqgplastvadfwqmvweq

DCGKIVMLTNTVEGEKRKCEKYWPDK-KMIYGKITVTRKSEEVNT-HYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNS
 .  ||.||.  | . ..|..||||. . .|.   |   || . .  | ||.| .  .  .. | | |||. |||..|||  . .|..| | | . .   
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

VGAIVVHCSAGVGRTGTFITLDAMLDQA-EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
  .||||||.|.||||..| .| .|..     . ||.   .  .|..| ..|.  .|..|.. |. |
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN14_pd Subfamily PTPN14 284-534 8.3e-57 187.5 In-house 26-294 (300) alignment 
Range on Protein: 284-534
Range on HMM: 26-294/300.0
KQDYESIPGGQLHP-LDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDpHSDYVNANFIDGY--NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVML
 ..|| ||  ...  |..||  ||..|||. ... |...||.|   ... ...|.||  |        | ||.||||    |.|||.||||..   ||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TNTVEGEKRKCEKYWPDK-----KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVK---QHHTNSV-
|.. |. | |. ||.|..     .. .||  || |  |  . .. ... .  .   . |.|. . || ||| |||.  .. ..... |.   .. ...| 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

-----GAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
       ..|||||||||||  |. | ..   | .. ||. . .. .|. |  .||   ||.|.|..|..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPN23_pd Subfamily PTPN23 305-534 5.4e-56 184.5 In-house 42-278 (288) alignment 
Range on Protein: 305-534
Range on HMM: 42-278/288.0
ENKQKNRYINIIAYDHSRVQLPllenDPHSDYVNANFIDGY-NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKM
 . .|||. .|. |||.||.|     . . ||.|| |. .   .   .||.|.|   .. |||.||.|.    ||||..  | .| |...|||    . .
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

IYGKITVTRKSEEVNTHYTVRTFSVVFG--DNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHT----NSVGAIVVHCSAGVGRTGTFITLDAMLD
 .|...|| ||..   ..  |.... .   |....|.  ..||||..|||.    |..|.  |.....    .|   .||||||||||||.|  . | . 
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QAEAENAI-DVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
. |..| . |. . .  .|..|  |||  ||..| |.| ||
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 300-534 1.2e-55 183.3 In-house 32-275 (287) alignment 
Range on Protein: 300-534
Range on HMM: 32-275/287.0
VAKKIENKQKNRYINIIAYDHSRVQLpLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK-
 |... . .|||| ... .|..|| |   | .  |||.|||.. .|.   ..||||||  |.|.||||.|.|.    ....|  ||  . || ||||.. 
aaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

-KMIYGKITVTRKSEE-VNTHYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH-----HTNSVGAIVVHCSAGVGRTGTFITL
  |  |  .|.  . .  . .|.||.. ..  .  . | | |... |||| ...  .  |. |.  ||||      .. || .|||...|.||.|.....
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
 ..... |    .|| . .  .|. |  .|| . |....|.||  
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
0051429 (Phosphotyrosine protein) phosphatases II 332-536 1e-52 174.7 In-house 2-225 (272) alignment 
Range on Protein: 332-536
Range on HMM: 2-225/272.0
PHSDYVNANFIDGYNY---PRRYIAAQGPNVASVKDFWRMvWEEDCGKIVMLTNTVEGEKRKCEKYWP-------------DKKMIYGKITVTRKSEEVN
| |.|.||....||..   |.|.....||  ....||||. .|...  ||.|....| .. ||..|||             .  . ||...||  |||. 
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

THYTVRTFSVV---FGDNIREVVQFHYTSWPDMGVPKytTPLMNFIRTVKQhhtnsVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAID--------V
..|..|.. ..     ...||| ..|||.|||.|||.   .| .... . .      |...||||||..||||.. |. .| . ..|  .|        .
ldyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

YNFITGMRQNRIKMVQVAEQYQFIYDALLETF
....  .|. | ..||  |||.|.|.|||| .
eeaveelraqrpgavqteeqylflyeallell
0041856 (Phosphotyrosine protein) phosphatases II 306-540 2.7e-52 172.3 In-house 1-175 (182) alignment 
Range on Protein: 306-540
Range on HMM: 1-175/182.0
NKQKNRYINIIAYDHSRvqlpllendpHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTntvegekrkCEKYWPDKKmiygki
|. |||| .|. |||||          ..||.|||...|. ...|.||.|||   .| ||.||..|.... ||.||         .| |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

tvtrkseevnthytvrtfsvvfgdnIREVVQFHYTSWPDMGVPKyTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQaeaenAIDVY
                          |...|..|..|||.|||  .  | .||..|..    . |...||||||||||||.. .. |. .      ....
.........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

NFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGD
. .  .|. | .||.  .||.|...|||| . ...
eavklvrsrRpgmvitpnqyfflqlallellllkk
0036282 (Phosphotyrosine protein) phosphatases II 334-530 1.1e-47 157.3 In-house 2-164 (174) alignment 
Range on Protein: 334-530
Range on HMM: 2-164/174.0
SDYVNANFIDGYNYPRRYIAAQGPNVasvkdFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDkkmiygkitvtrkseevnthytvrtfsvVFGDNIRE
||| ||...|..  ..|.|| |||       ||.|..|...  .|||.. .| .. ||  |||.                               |  |.
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredlerl

VVQFHYTSWPDMGVPKYTTpLMNFIRTVKQHHTN-SVGAIVVHCSAGVGRTGTFITLDAMLDQAEaENAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
..|..|. |||.|||  .. | .|.. |.... . . | ..||||||||||||.. .. || . . |...|.....  .|. | .|||  .||.|.|.
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 305-534 3.2e-46 152.3 In-house 55-281 (290) alignment 
Range on Protein: 305-534
Range on HMM: 55-281/290.0
ENKQKNRYINIIAYDHSRVqlpLLENDPHSDYVNANFIDGYNYPrrYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK---MI
 . .|||| ...  | .||   .|..  . ||| ||...| . .  .| .||.  ..| |.|||| .|.   |||| . .|  | |||.|.|.|.   . 
tefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGKITVTRK-SEEVNTHYTVRTFSVVFGDNIREVVQFHY--TSWPDMGVPKYTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQAEA
.|.|||.   ... ...   .|.||   |. .| .  |.   ||||  |.. |  |.  .|....      | .|||||||.||||||..... |.    
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilld

ENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
  ..|. . .  .|. |.. |||  ||  . ..||.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 278-537 3.9e-43 142.1 In-house 8-270 (281) alignment 
Range on Protein: 278-537
Range on HMM: 8-270/281.0
STKNGFKQDYESIPGGQLHPLD-VAKKIENKQKNRYINIIAYDHSRVQLPL-LENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCG
 | . |||..  .||     |  | ..  |..||||.|| . | ||||| . . |   .||. ||.|      | || .|||.  .  |||||.|.|.  
mtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentt

KIVMLTNTVEGEKRKCEKYWPDKK---MIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvgai
 |||| . .| .. || .|.| .    . . |..|. .   ||       . . .  . | . .. .  |||  ||. .  ... .| .. . |      
aivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstpp....

VVHCSAGVGRTGTFITLDAMLDQAEAENAI-DVYNFITGMRQ-NRIKMVQVAEQYQFIYDALLETFV
|.||||||||.||.....  |.   .  .. |. . .. .|   |   ||  .|| .|.  ||.  |
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 305-534 2.2e-42 139.9 In-house 32-257 (267) alignment 
Range on Protein: 305-534
Range on HMM: 32-257/267.0
ENKQKNRYINIIAYDHSRVQLPLLENDphsdYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRkceKYWPDK---KMI
.|...||. . . ||..|| |   |..    |.|| ...||.  . .|. |.|   .. ||. .. ....  ||.||.. ... |   ..|| |      
knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir...lfwPPkmgqakk

YGKITVTRKSEEVNTHYTVRTFSVVFGDN-IREVVQFHYTSWPDMG-VPKYTTPLMNFIrtVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE
|  .|| .  |. .  | . |. . | ..  ..|. ..|  |        |  ||.  .   |..  |    .||.||.||||.|||...|..|..|  |
yqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.  |...|.  .|. || .|.. |.| .|.. | |
gvsdifdflrkirsqriglvdtkeryiyihellae
0049772 (Phosphotyrosine protein) phosphatases II 298-535 2.4e-42 141.1 In-house 38-279 (314) alignment 
Range on Protein: 298-535
Range on HMM: 38-279/314.0
LDVAKKIENKQKNRYINIIAYDhSRVQLPLLENDPhSDYVNANFIDGYnypRRYIAAQGPNVASVKDF----------WRMV--WEEDCGKIVM------
. ||.. .|. ||||..|. .| .||.|| |...  ||| ||...||.   ...||.|||.   | ||          ||||  .. ..  |||      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTNTVEGEKRKCEKYWPDKKmiygkitvtrkseevnthyT-------VrtfsvvfgdnIREVVQFHYTSWPDMGVPkYTTPLMNF
               |..  ..    ....... |                   .       .           |........ .|| ..|  .  .  |
adelsrLdaAlgKtpllildgngneptaadlellk...................eelydpelf..........erlgikylripvpDgsap.lledfdef

IRTVKQHhtNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAeNAIDVYNFITGMRQ---NRiKMVQVAEQYQFIYDALLET
.. ....  .  |...|||.||.||||||.... .. .    .. ......  .|    |.  ...  |||.||..|||| 
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp.gfieqleqyefilealley
0046846 (Phosphotyrosine protein) phosphatases II 328-534 5e-42 138.9 In-house 6-171 (176) alignment 
Range on Protein: 328-534
Range on HMM: 6-171/176.0
LENDPHSDYVNANFIDGYnyprRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDkkmiY----Gkitvtrkseevnthytvrtf
|  |...||.|||.|.|.    |.|| ||| . .. ||..|..|.... .|.||. || .. ||  |||.    .                         
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi....................

svvfgdnirevvQFHYTSWPDMGVPKYtTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLDqaeaENAIDVYNFITGMRQNRI-KMVQVA
            |.... |||.||| . . |..... .... ..  | ..||||||.|||||.. .. .      |. ..|.. .  .|. |  ..||  
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtp

EQYQFIYDALLE
|||.|.|...|.
eQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 331-529 5.9e-42 138.6 In-house 2-154 (172) alignment 
Range on Protein: 331-529
Range on HMM: 2-154/172.0
DPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTvegekrkcekywpdkkmiygkitvtrkseevnthytvrtfSVVFGDN
|..|||.||...|.|  |.|.|| |||    . |||||..|.... ||.||.                                          .   . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpell

IREVVQFHYTSWPDMGVPkYTTPLMNFIRTVKQ-HHTNSVGAIVVHCSAGVGRTGTFITLDAMLdqaeaeNAIDVYNFITGMRQNRIKMVQVAEQYQFIY
 |...|..|..|||.|||  .  |..|.. ... .. .. |...||||||||||||.. .. ||        ..... .  .|. | ..||  .||.|.|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
subfamily_ptpA1_pd Subfamily ptpA1 302-494 7e-42 138.6 In-house 43-254 (418) alignment 
Range on Protein: 302-494
Range on HMM: 43-254/418.0
KKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGyNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---
 |  |  |||| ||.  .|.||||  ...   |||.|||.|||  ||...|..|||   .. ||||||||. |  ||||.   |  . ||..|||..   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

--KMIYGKI---TVTRKSEEV------NTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNS------VGAIVVHCSAGVG
    |||.      |   | |      .     |   . |  . |.. |..|  |||  .| .| |. ...... ... .          |.||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTFITLDAMLD
||||| |   |. 
rtgtfctavimmk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 305-538 8.3e-42 138.2 In-house 40-279 (307) alignment 
Range on Protein: 305-538
Range on HMM: 40-279/307.0
ENKQKNRYINIIAYDHSRVQLPLleNDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMI
 | .|||| .. . |..|. . .  .   |||. ||..     |...|.||||  ... .|| |. .|.   ..|| ...|  | |||.|||    .|..
antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YGKI----TVTR----KSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhHTNsvgAIVVHCSAGVGRTGTFITLDAML
.|.     .|.     |    .    | |. |..... | . .. .. ||| |||.     .|.. .|.  .||    .||||||||||.|| ...  . 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.dtn...pvvvhcsaGvGrsGtivaislvq

DQA-EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
|.  . .|  |. ...  .|..|   .|   || ...  ||| |. 
dkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
0049260 (Phosphotyrosine protein) phosphatases II 341-530 5e-41 135.2 In-house 1-144 (152) alignment 
Range on Protein: 341-530
Range on HMM: 1-144/152.0
FIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWpdkkmiygkitvtrkseevnthytvrtfsvvfgdnirevvQFHYT
|||||..|...||.|||   ...|||||..| ... |||||. .|  | |||.|.                                        |....
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhl

SWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLdqaeaeNAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
 |||.|||. .  |. ... ....  .. | ..||||||||||||.. .. ||      . .......  .|. | ..|.  .|..|.|.
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 585-668 2.5e-40 133.4 In-house 40-124 (315) alignment 
Range on Protein: 585-668
Range on HMM: 40-124/315.0
ELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
 |..|....|..||||......||||..| ..|......|.||.|..||.||......|.|....|.|||||||...|..|.||.
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmlt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 267-536 2.5e-38 126.5 In-house 8-287 (305) alignment 
Range on Protein: 267-536
Range on HMM: 8-287/305.0
QLITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLplLENDPHsDYVNANFIDGYNYPRRYIAAQGPNVASVKDF
|.. .| .    . .|..... ..    ... .   |. ....|||| ..   |. ||.|      || .|. ||..     |.|.| .| |   .  ||
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadf

WRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK---MIY----GKITVTRKSEE-----VNTHYTVRTFSVV---FGDNIREVVQFHYTSWPDMGVPKY
| | ...   .| || | .|   .|| .|.. |.   . .     ||.|  .| .      ... .|.   .|    | . | | ..|.  ||| |||  
wymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa

TTPLMNFIRTVKqhhtNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVY-NFITGMRQNRIKMVQVAEQYQFIYDALLETF
 . .....   .     | | ||||||||.||||. . |. .|||  | . |.     .  .|..| . .|  .|| |... .|. |
dlailellekar....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 281-538 6.1e-38 125.5 In-house 19-273 (288) alignment 
Range on Protein: 281-538
Range on HMM: 19-273/288.0
NGFKQDYESIPGGQlhPLD-VAKKIENKQKNRYINIIAYDHSRVQLPlleNDPHSdYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVM
.| |..|.  | .   . | . . |.|  ..|| |.   | .||.|    .||.  |..|| .   .|.|| | || |  . .. .|.|. |.|   |||
eglkkeyrdspnea..sidiidsfianptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

LTNTVEGEKRKCEKYWPDK---KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVV---QFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTnsvgAIV
|.. .|  |.| ..|.| |   |. .|..    | . .. . .|.   .    .. | |   . |.  |.| |||.   . ....  .|...      ||
lcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....Piv

VHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
||.|||||||||.|    .|...  .. . . .... .|..| | .|.  || ...  .|| .. 
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 306-537 1.1e-37 124.4 In-house 55-290 (305) alignment 
Range on Protein: 306-537
Range on HMM: 55-290/305.0
NKQKNRYINIIAYDHSRVQLpllENDPHSDYVNANFIDGYNYP-RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP----DKKM
.. |||| .. . |.| |.|   .. . |||. ||..     | .|.|.||||   .. .|| || ..   .|||| .|||  | || .|||    .|. 
aitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

IYGKITVTR----KSEEVNTHYTVRTFSVVF-GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQ
. . | |      |  | ..   . .. . . ||.   | ....| ||| |||      .... ...     |   ||||||||.||||| .... .|..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilek

-AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFV
 ||  ..  . ...  .|..|   .|   || ||.  .|. |.
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
0044763 (Phosphotyrosine protein) phosphatases II 318-535 2.8e-37 123.4 In-house 2-170 (178) alignment 
Range on Protein: 318-535
Range on HMM: 2-170/178.0
YDHSRVQLPLLENDPHSDYVNANFIDGYnyprRYIAAQGPnvasvKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMiygkitvtrkseevnth
.|..|| |. ||. . ||| ||..|...     |.....|      |......|.... ||.||...|. . || .|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

ytvrtfsvvfgdnirevVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQaeaenAIDVYNFITGMRQNRIk
                 .|.... .||.|||  .  ...|.. ..... .. |...|||||||||.||.. .. |. .      ..... |  .|. |  
.................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.

MVQVAEQYQFIYDALLET
.|.  .|....|.  |. 
ivpnpgqlrqLyefelrl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 427-572 1.8e-35 117.1 In-house 84-230 (440) alignment 
Range on Protein: 427-572
Range on HMM: 84-230/440.0
FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQY
 | . | . |.|| .||| ||||.. |....|. |.. .   . | ..||||||.||||  |..|..| .|.  . ||...||  ||.|| .|||. |||
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

QFIYDALLETFVCGDTSIAQDLYLQRYPSLLAPSPDTGSTLLQEQFE
 |...|.|| ..|||| | .|   .|   .  |.| |  . ||..||
afvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
0051082 (Phosphotyrosine protein) phosphatases II 332-533 2.3e-35 116.8 In-house 1-150 (151) alignment 
Range on Protein: 332-533
Range on HMM: 1-150/151.0
PHSDYVNANFIDGYnyprrYIAAQGPnvasVKDFWRMVWEEDCGKIVMLTNTVEGEkrKCEKYWPDKKmiygkitvtrkseevnthytvrtfsvvfgdni
|.||| |.....|.     ... .||      ||.....|...  ||.|....| .  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

REVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhhtNSVGAIVVHCSAGVGRTGTFITLDAMLDQaeaenaIDVYNFITGMRQNRIKMVQVAEQYQFIYDA
.||.......||| |.| ..  ...|.. . .   .. | ..||||||.|||||.. |. || .      ....  .  .|. |  .||  .|..|.. |
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

LL
||
ll
PTPc_DSPc_SM00012 434-534 4.7e-35 115.3 In-house 2-105 (105) alignment 
Range on Protein: 434-534
Range on HMM: 2-105/105.0
VVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSV--GAIVVHCSAGVGRTGTFITLDAMLDQAEAE-NAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
| ..|||.|||.|||..........| ||.....|   . .||||||||||||||..|| .|.| |.| . .|.....  .|. | .|||  |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 281-547 5.7e-34 112.1 In-house 27-300 (310) alignment 
Range on Protein: 281-547
Range on HMM: 27-300/310.0
NGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPlLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVML
.|. ..|  .   |   |      .. .|||| ...  | |||.|  ...  . ||. ||..        .| .|||   .. |||||...| .  |..|
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TNTVEGEKRKCEKYWPDKKM--IYGKITVTRKSEEVNtHYTVRTFSVVF-GDNI---------RE--VVQFHYTSWPDMGVPKYTTplmnfiRTVKQHHT
 ...|  . ||  |||   .   || | ||  ||  .  . .  ..| |  ||.         .|  |   ..  |||.|||           || |   
ckvgeegrpkcvgywpslgvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrll

NS--VGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIyDALLETFVCGDTSIAQDL
     |  |||||||..|... ..|.  .|...  . .|. . .| ....|.. .|   || .| | .   |. |.| .|...
aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii.drvriifargetevaeki
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 335-526 1.7e-32 107.4 In-house 76-271 (301) alignment 
Range on Protein: 335-526
Range on HMM: 76-271/301.0
DYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---KMIYGK--ITVTRKSEEVNTHYTVRTFSVVFGD
  . ||.|.    |.|.||.|||  .. .||| |.   |  |||||...|| ...|||.| | |   |.  |.  |... |   .| . . ||. |.   
vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedst

---NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQ
   . | |. . |..|.| ||||  . |....  ||.    |   ||||||||.||. .||. . .  . ||.. |.. . .  .|..| . ||  .|  
gkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_CG42327_pd Subfamily CG42327 287-462 6.2e-32 105.5 In-house 11-191 (319) alignment 
Range on Protein: 287-462
Range on HMM: 11-191/319.0
YESIPggQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVE
.. .|  ||     .  .  |.|.|.||..   ..|| |.   .|... |..|... ||.  |  ||||| .   |  ||||.|||     || ||.  |
frdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlse

GEKRKCEKYWPDK-----KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYtSWPDMGVPKYTTPLMNFIRTVK
   ..| .|.| |     .  ||.| || |  ||. .| . |. .  | ... ||.  . |  |.. .||   ..|.  .  |.
lGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 300-457 1.2e-31 104.7 In-house 27-189 (297) alignment 
Range on Protein: 300-457
Range on HMM: 27-189/297.0
VAKKIENKQKNRYINIIAYDHSRVQLplLENDPHSDYVNANFIDGYN--YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD
.||.    .|||| .|.|.| .||.|  |   . .||.||...   .   . .|| ||||  |.|.|||..|.|.| . |||...  |. . ||  |||.
sakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

K---KMIYGKITVT---RKSEEVNTHYTvRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
    ..  |.. |    . |.| .. .    . ... .. | |    . |||| |||     |  |
vvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 306-538 1e-29 98.4 In-house 35-272 (285) alignment 
Range on Protein: 306-538
Range on HMM: 35-272/285.0
NKQKNRYINIIAYDHSRVQLpllENDpHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK---MI
| . ||| .. . . .|| |   .|    ||. |...         ||..|||   .. |||.|...|    ..||   .||   ||  |.|.|    . 
npdlnryadvrcieetrvvl...knh.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGK--ITVTRKSEEVNTHYTVRTFSVVFGDN-IREVVQF---HYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLDQ
.||  ||.|   ||  .   . ...|.  ..   | . .   .   |||   |. . |.... . ||.   .    |.|||||||||| ||. .|    .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyatir

AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
   .  |.. . .  ||  |.. ||   |. |.|  |.| |. 
imenpniemldivremramrfqavqshmqflflyvvlmeyfig
0051299 (Phosphotyrosine protein) phosphatases II 549-668 1.4e-28 95.7 In-house 11-124 (288) alignment 
Range on Protein: 549-668
Range on HMM: 11-124/288.0
LQRYPSLLapspDTGSTLLQEQFERLDMFTIKprdDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPN
|...  ||     .| |.|.|.||.|  ....    .|..|.   |..|||| | || |.|| .| .. . .|..|||||...|| .|  |. ||.||||
lklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVGDFWRLVFDYKISTIIMLN
||.||||.|.......|.||.
tvedFWrmvweqnvrvIvmlt
0050432 (Phosphotyrosine protein) phosphatases II 562-668 1.9e-28 95.1 In-house 39-140 (308) alignment 
Range on Protein: 562-668
Range on HMM: 39-140/308.0
TGSTLLQEQFERLDMFTIkprDDELRTARNSMNVHKNRYHDKLPTDKSRPYLitevENGTNYINASFLPGY--TKKDMFLGTQTPLPNTVGDFWRLVFDY
....||.|.||.| ....   . | ..|.   |..|||| | || |.|| .|    ..|..|||||. .||   ..  |. || ||||||.||||.|...
ldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

KISTIIMLN
....|.||.
nvrvIvmLt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 554-668 3.9e-28 93.6 In-house 16-131 (298) alignment 
Range on Protein: 554-668
Range on HMM: 16-131/298.0
SLLAPSPDTGSTLLQEQFERLDMFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDF
 | | ..... | ....|.||.  . . ...| . ||.. | .|||| | .. |.||  | . . .. ..||||||| .|.... |. ||.||..|| ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRLVFDYKISTIIMLN
||.| ...|.||.||.
WrmvteedigtiVmlt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 302-536 8.4e-28 92.0 In-house 39-276 (312) alignment 
Range on Protein: 302-536
Range on HMM: 39-276/312.0
KKIENKQKNRYINIIAYDHSRVQLPLLENdphsDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---
  .  |. ||| ||  .|  |  |   ||     |. |||.     | |....|||   ..  ||...    .  |..|.  ||    || ||  |    
aflkfkdlnrypniqcwdrgrftlagden....fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf

-----KMIYG----KITVTRKSEEVNTHYTVRTFSVVFGDNiREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTnsvgAIVVHCSAGVGRTGTFITL
     . .|     .| .  || .  ||  ..      |..   . .. ..|||| |.|      . .. .||. .      .. |||||||||||.. .
vdledhrvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlali

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
..|.         .| .    .|..| . |.|  || .   ..|| .
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
0047943 (Phosphotyrosine protein) phosphatases II 562-668 6.8e-27 90.0 In-house 9-109 (273) alignment 
Range on Protein: 562-668
Range on HMM: 9-109/273.0
TGSTLLQEQFERLDMFTIkprDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiteVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKI
.|.|||.|.||.|  ...   . . ..|.   | .||||.| || |.|| .|    ..|..|||||...|| .|  |. ||.||||||.||||.|.....
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

STIIMLN
..|.||.
rviVmLt
0036941 (Phosphotyrosine protein) phosphatases II 562-668 8.7e-27 89.6 In-house 10-110 (297) alignment 
Range on Protein: 562-668
Range on HMM: 10-110/297.0
TGSTLLQEQFERLDMFTIkprDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiteVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKI
....||...||.|. . .   . .|..|..  |..||||.| || |..| .|    ..|..|||||...||  |  |. ||.||||||.||||.|.....
lflalllkefeellplll...lgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

STIIMLN
..|.||.
tvIvmlt
0046845 (Phosphotyrosine protein) phosphatases II 567-668 9.4e-27 89.5 In-house 2-109 (284) alignment 
Range on Protein: 567-668
Range on HMM: 2-109/284.0
LQEQFERLDMFTIKPRdDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFLPGY-----TKKDMFLGTQTPLPNTVGDFWRLVFDY
|.|.||.| ..|.|.   .|..|.   |..|||| | || |.|| .| .. .  ....|||||...||      .|  |. ||.||||||.||||.|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KISTIIMLN
....|.||.
nvrvIVmlt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 566-668 1.1e-26 88.6 In-house 22-122 (288) alignment 
Range on Protein: 566-668
Range on HMM: 22-122/288.0
LLQEQFERLdmfTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
 ..|... |   .   ....  ..|.. | .||||.. || |  |  |   | |.|..|||||.. |. ||  .. ||.||..||.|||.||...|.|||
gfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti

IMLN
.||.
vmlt
0045450 (Phosphotyrosine protein) phosphatases II 556-668 2.9e-26 88.4 In-house 18-139 (307) alignment 
Range on Protein: 556-668
Range on HMM: 18-139/307.0
LAPSPDTGSTLLQEQFERLDMFTIKPrDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFL--------PGYTKKDMFLGTQTPL
..  . .. |.|...||.|  .|...  .| ..|.   | .|||| | || | .| .| .. .  ....|||||.         .|| .|. |. ||.||
vllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

PNTVGDFWRLVFDYKISTIIMLN
|.|| ||||.........|.||.
petvedFwrmlweqgvtvivmlt
0048076 (Phosphotyrosine protein) phosphatases II 413-533 4.4e-26 86.7 In-house 24-140 (145) alignment 
Range on Protein: 413-533
Range on HMM: 24-140/145.0
EVN--THYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLDqaeaENaIDVYNFITG
.     ..|| ...  . .  |...|..|..|||.|||  .  |..|.. ..... .  | ..||||||||||||.. .. ||     .. ..... .  
llkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealel

MRQNRIKMVQVAEQYQFIYDALL
.|. | ..|.  .|..|.|...|
vrsqrpgavpnpgqlrflyefel
0039614 (Phosphotyrosine protein) phosphatases II 562-668 5.8e-26 87.1 In-house 29-133 (297) alignment 
Range on Protein: 562-668
Range on HMM: 29-133/297.0
TGSTLLQEQFERLDMFTIkprdDeLRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFD
...|||...||.|  ...    |  ..|.   |..|||| | || | || .| .| .  ....|||||...|| . .. |. ||.|||.||.||||.|..
nsktllllefeellslkp....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKISTIIMLN
.....|.||.
qgvtvivmLt
0040438 (Phosphotyrosine protein) phosphatases II 565-668 5.9e-25 83.6 In-house 18-118 (317) alignment 
Range on Protein: 565-668
Range on HMM: 18-118/317.0
TLLQEQFERLDMFtikP-RddELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
|.|.|.||.|. .   .    . ..|.   | .|||| | || | || .|  . . ....|||||. .|. .|. |. ||.||||||.||||.|......
talleefedllsl...kld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIIMLN
.|.||.
vivmLt
DSPc_SM00195 567-668 6e-25 83.4 In-house 2-101 (263) alignment 
Range on Protein: 567-668
Range on HMM: 2-101/263.0
LQEQFERLDMFTIKPrddELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTII
|.|.||.|.. | .    | ..|. . |..|||| . || |..|  | .| . .|..||||... |..||  .  || |||.|| ||||.|.. |...|.
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLN
||.
mlt
PTPc_SM00194 567-668 6e-25 83.4 In-house 2-101 (263) alignment 
Range on Protein: 567-668
Range on HMM: 2-101/263.0
LQEQFERLDMFTIKPrddELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTII
|.|.||.|.. | .    | ..|. . |..|||| . || |..|  | .| . .|..||||... |..||  .  || |||.|| ||||.|.. |...|.
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLN
||.
mlt
subfamily_egg_pd Subfamily egg 297-534 6.3e-25 82.5 In-house 31-268 (307) alignment 
Range on Protein: 297-534
Range on HMM: 31-268/307.0
PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGekRKCEKYWP
.|  | . .|..| |   .   | |||.| | .     |.. || ..|      .| || |   .|.||||||..|..  ||||| ..|    .|| |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

DKK-----MIYG--KITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGvpKYTTPLmNFIRTVKQHHTnsvgAIVVHCSAGVGRTGTFITL
  .     .. |  .|.  .  .. .  ..|  . .| ||.    ..     .  ..  .  .|| . .| ...  .     .||..  || ...|....
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnss..dvyspl.rvlrklrnlsk....pvvvqdilGvskaatlvai

DAMLDQAE--AENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.  | .          | . .  .|..|   |. . .| |.|  .| 
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 561-668 6.9e-25 82.8 In-house 19-123 (319) alignment 
Range on Protein: 561-668
Range on HMM: 19-123/319.0
DTGSTLLQEQFERLDmftiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDY
.||.|||...|. |.    .. .|....| .  | .||||.. |. |..|  | . .  .|..||||||. || ... |. ||.|| ||. ||||.|...
stgetllekefkllk....eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWee

KISTIIMLN
..|...||.
essivvmlt
0048179 (Phosphotyrosine protein) phosphatases II 427-530 8.5e-25 82.6 In-house 42-139 (144) alignment 
Range on Protein: 427-530
Range on HMM: 42-139/144.0
FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLdqaeaENAIDVYNFITGMRQNRIKMVQVAEQYQ
  . .||..|.....|||.||| ... | .|.. ..... .. | ..||||||||||||..... |.     .. ..... .  .|. |  .|.  .|..
pefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlr

FIYD
|...
fLle
0043336 (Phosphotyrosine protein) phosphatases II 562-668 1.3e-24 82.5 In-house 17-120 (278) alignment 
Range on Protein: 562-668
Range on HMM: 17-120/278.0
TGSTLLQEQFERLDMFTIkprdDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
.. |||...||.|. |..    |. ..|.   |..|||| | || | || .|   . .....|||||...|| ... |. ||.|||.||.||||.|....
nlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

ISTIIMLN
..||.||.
vttivmLt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 349-530 2.6e-24 80.5 In-house 4-197 (198) alignment 
Range on Protein: 349-530
Range on HMM: 4-197/198.0
RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKM---IYGKITVTRKSEEVNTHYTVRTFS----VVFGDNIREVVQFHYTS
|||||.| |   .. |||.||||   |.|||. .     .     |||  .     || ..|| |.  ..  ||. ..     .      ||. .. .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGVPKYTTpLMNFI---RTV-KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE--NAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
| .   |. .  .. |.   | | |..  .    ..|||| | | || |..||  .   |      .|...    .|| |  ..   ..|.|||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 349-530 2.8e-24 80.4 In-house 5-198 (199) alignment 
Range on Protein: 349-530
Range on HMM: 5-198/199.0
RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKM---IYGKITVTRKSEEVNTHYTVRTFS----VVFGDNIREVVQFHYTS
|||||.| |   .. |||.||||   |.|||. .     .     |||  .     || ..|| |.  ..  ||. ..     .      ||. .. .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGVPKYTTpLMNFI---RTV-KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE--NAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
| .   |. .  .. |.   | | |..  .    ..|||| | | || |..||  .   |      .|...    .|| |  ..   ..|.|||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 571-667 3.8e-24 80.0 In-house 16-111 (287) alignment 
Range on Protein: 571-667
Range on HMM: 16-111/287.0
FERLDMFTiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
...|   . .     ...| . ..|.|||| | || |..|  | .| | |..|||| ....||... |. .|.|.. ||.||||.|.. . ...|..
vdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 577-668 9.4e-24 79.1 In-house 29-123 (325) alignment 
Range on Protein: 577-668
Range on HMM: 29-123/325.0
FTIKPRDDEL--RTARNSMNVHKNRYHDKLPTDKSRPYLITEVENG-TNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
| . | ||    ..|    |. |||... .. ||||. | |  ... ..|||||.|  . |||.|| .|.||..|..|.||||.|.. | ...||
fgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvln
subfamily_PTPRB_pd Subfamily PTPRB 565-667 2e-23 77.9 In-house 25-125 (293) alignment 
Range on Protein: 565-667
Range on HMM: 25-125/293.0
TLLQEQFERLDMFTikpRDDELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIST
. ..|..|.|  .    .| .  .|....|  ||||.. || |.||  |  .. |.|..||||...|||. .  |. || |||.|| ||||.|.. | |.
lrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IIML
|.||
ivml
subfamily_PTPRG_pd Subfamily PTPRG 563-667 2.3e-23 77.3 In-house 17-122 (563) alignment 
Range on Protein: 563-667
Range on HMM: 17-122/563.0
GSTLLQEQFERLDMFTiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
| . ..|.|| | . | ...| .  ....  | .|||| . .. |.||  |    .  .  .||||... || |.. |..|| ||..|. ||||.... .
gdigfseefealqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

ISTIIML
 ..|.|.
vaiivmi
subfamily_PTPRK_pd Subfamily PTPRK 588-668 3.2e-23 77.0 In-house 37-118 (314) alignment 
Range on Protein: 588-668
Range on HMM: 37-118/314.0
TARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
.|..  | .|||..| |. |.||. |||  ..  ..||||... .|..   |. || ||..|| ||||||.|.. ..|.||.
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 581-667 3.3e-23 77.3 In-house 33-120 (305) alignment 
Range on Protein: 581-667
Range on HMM: 33-120/305.0
PRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENG-TNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 ... .   ....|..|||.... . |..|  | .. ... ..|||||.. || .|. .. .|.||.||| |||||....|.|||.||
eeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivml
subfamily_PTPN12_pd Subfamily PTPN12 565-667 6.6e-23 76.0 In-house 8-114 (290) alignment 
Range on Protein: 565-667
Range on HMM: 8-114/290.0
TLLQEQFERLDMFTIKPRDDE---LRTARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
  ....|..| . . | ....     ..... ||.||||.| || ||||  | .. |. | .||||.|. | ..| ... .|.|||.|. ||||......
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

ISTIIML
.. ..|.
veivvma
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 588-667 1.2e-22 75.3 In-house 40-120 (318) alignment 
Range on Protein: 588-667
Range on HMM: 40-120/318.0
TARNSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 . ...| .|||| . |. |..|  |  .|.|.|..||||....||..|  .. .|.|||.|. ||||.|.. . ..|.||
kslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 305-533 1.3e-22 74.6 In-house 50-282 (302) alignment 
Range on Protein: 305-533
Range on HMM: 50-282/302.0
ENKQKNRYINIIAYDHSRVQLPlleNDpHSDYVNANFIDGYNYPRRYIAAQGPNVASV---KDFWRMVWEEDCGKIVMLTNTVEGEKrKCEKYWP---DK
.| .||.  .. ..|. .|.|.   .    .||||  ..  .  |  | || |.| |.    .|||||..| . ..|.|  . | .|   ....|   ..
knlkknqsedvpildsnlvkle...ae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

KMIYGKITV-TRKSEEVN---THYTVRTFSVVFGDNIREVVQfHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLD
   |||. | .|| |...   |.|..  .   . . .   |. . | |..  ||.  . |.. .  | ......   .|.    |.|| |.|.|| . ..
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy.vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
. .....  . . .. .|..| ..|. ..|| ..| |||
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 299-412 1.4e-22 74.9 In-house 40-167 (350) alignment 
Range on Protein: 299-412
Range on HMM: 40-167/350.0
DVAKKIENKQKNRYINIIAYDHSRVQLP--L------LENDPHSDYVNANFIDGY------NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTV
 ... .|   |||| ||. |.||||.|.  |            .||.|||..         |   .|||.|.|    |.||.... . .   |..||. |
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EGEKRKCEKYWPDKKMIYGKITVTRKSE
| . .||..||.. ..   .. .. | |
elnlekcyrYWqegsydditvklaskwe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 589-668 2.6e-22 74.2 In-house 4-84 (250) alignment 
Range on Protein: 589-668
Range on HMM: 4-84/250.0
ARNSMNVHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
|..  | .|||| | .. |.||  | .|  .. ..||||||| ||.....|. ||.||..|. ||||.|...|..||.||.
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 591-667 6.5e-22 73.2 In-house 58-135 (319) alignment 
Range on Protein: 591-667
Range on HMM: 58-135/319.0
NSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
   |  |||. . |. ||..  |  .. |....||||||. || .||... .| ||.||. ||||....|..|||..|
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll
0045098 (Phosphotyrosine protein) phosphatases II 584-668 7.3e-22 73.5 In-house 23-96 (278) alignment 
Range on Protein: 584-668
Range on HMM: 23-96/278.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYlitevengtNYINASFLPGYtkKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
.|  .|    |..||||.| || | || .         .|||||...||  .. |. || |||.|| ||||......|..|.||.
seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 592-667 8.1e-22 73.0 In-house 23-99 (284) alignment 
Range on Protein: 592-667
Range on HMM: 23-99/284.0
SMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
  |  |||. . |. ||..  |  .  |....||||||. || .||... || ||.||. ||||....|..|||..|
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 580-668 1.2e-21 71.9 In-house 30-119 (315) alignment 
Range on Protein: 580-668
Range on HMM: 30-119/315.0
KPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
 |   . |.||...| .||||.. || |..|  | . . .   .|||||..... .   .. .|.||. .| ||||.|...|..||.|..
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt
subfamily_PTPRA_pd Subfamily PTPRA 567-667 2.4e-21 71.0 In-house 34-132 (330) alignment 
Range on Protein: 567-667
Range on HMM: 34-132/330.0
LQEQFERLDMFTIKprdDELRTARNSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTII
..|.|. |   .|.     | .| .  | .|||. . || | || .|   | .. ..||||||. || .|| |. .| |. .|| ||||.....| .||.
freefnalPagpiq...atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativ

ML
||
ml
Y_phosphatase Protein-tyrosine phosphatase 594-668 2.4e-21 71.6 Pfam-A 1-74 (235) alignment 
Range on Protein: 594-668
Range on HMM: 1-74/235.0
NVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
| .||||.| || ||.|  | .. |. ..||||... ||..| .|. || ||..|..||||.|...|...|.||.
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmlt
Y_phosphatase Protein-tyrosine phosphatase 594-668 2.4e-21 71.6 In-house 1-74 (235) alignment 
Range on Protein: 594-668
Range on HMM: 1-74/235.0
NVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
| .||||.| || ||.|  | .. |. ..||||... ||..| .|. || ||..|..||||.|...|...|.||.
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmlt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 587-668 4.7e-21 70.2 In-house 44-124 (297) alignment 
Range on Protein: 587-668
Range on HMM: 44-124/297.0
RTARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKkdMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
 .|.. .| .|.||.. ||.|.||  |    ..   .|.||||..|. .   .. ||.| ..|| |||..|.|...|||.|||
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln
subfamily_PTPN9_pd Subfamily PTPN9 583-667 4.9e-21 70.0 In-house 31-116 (297) alignment 
Range on Protein: 583-667
Range on HMM: 31-116/297.0
DDELRTARNSMNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
  .. ...  .|..||||.| |  |..|  | ..  .. ..||||.|. || .|. |..|| ||..|| ||||.|.. .. .|.| 
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 299-535 6.8e-21 69.2 In-house 38-278 (303) alignment 
Range on Protein: 299-535
Range on HMM: 38-278/303.0
DV--AKKIENKQKNRYINIIAYDHSRVQLpllendPHSDYVNANFIDgYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP
.|   . ..| .|||....|  |||.|.|        | |. |....  .  .. | .| |   .  |||.|. |.    ...|    | .|   .  .|
svsknqfvknmdknrfvdvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

DKKMIY----GKITVT-RKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPL-MNF---IRTVKQHHTNSVGAIVVHCsAGVGRTGTFI
 .. .       | |   |  |.   ....  ||  ||    .   || .||   .|  ..|  ..    ...| .....|  .. .   .|.||.||| 
rnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsl.sgcgragtfa

TLD-AMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
 .. | |   . ....|. . .  .|. |.. ||   |. ..|  | | 
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 306-531 7.8e-21 69.5 In-house 18-254 (290) alignment 
Range on Protein: 306-531
Range on HMM: 18-254/290.0
NKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDgYNYPRRYIAAQGPNVAS-------VKDFWRMVWEEDCGKIVMLTNTVEGEKR----KCEKY
...... ...    ..|| |    .   .||. ||..  .    | |. | |  .        ...|| |. .|   ..||| .  | ..      |.||
khemdqRlevpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPDK---KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFH-YTSWPDMGVPKYTTPLMNFIRTVKQHHTnsvgAIVVHCSAGVGRTGTFITLD
 |..   .. .. .||  || | .    .|.  | |.|.    |. . . .| .. |.. |  |.. |..||...|    ...|||  |. |  .. ...
vpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaii

AMLDQ-AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDA
      || .... . . .  .|..| .... |... |.  .
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag
0040439 (Phosphotyrosine protein) phosphatases II 587-668 8.5e-21 70.1 In-house 4-86 (249) alignment 
Range on Protein: 587-668
Range on HMM: 4-86/249.0
RTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
..|.   |..||||.| || | ||..|    . ....|||||...||  |. |. ||.|||.||.||||......|..|.||.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLt
0042113 (Phosphotyrosine protein) phosphatases II 588-668 1e-20 69.6 In-house 3-84 (245) alignment 
Range on Protein: 588-668
Range on HMM: 3-84/245.0
TARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
.|.   |..|||| | || | .| .|  . .. ...|||||. .||  .. |. || |||.||.||||......|.||.||.
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 564-668 1.2e-20 68.1 In-house 17-118 (515) alignment 
Range on Protein: 564-668
Range on HMM: 17-118/515.0
STLLQEQFERLDMFTIKPRddelRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
 ||. |.|  |    | |.      |.. .| .||||.. || |..|  | . . .   .|.|||..|..     .. .|.|.. .| ||||||......
ttlfseefhdlpgpniypq....tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

TIIMLN
||.|..
tiamvt
subfamily_eak_pd Subfamily eak 299-462 1.5e-20 67.9 In-house 45-208 (332) alignment 
Range on Protein: 299-462
Range on HMM: 45-208/332.0
DVAKKIENKQKNrYINIIAYDHSRVQLPLLENDPhSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK
 .....|. ..|  ..|. ||.  |.|     ..   |.||  ..  .  |.|| .  ..   |  ||.|| |.    ||.| . || .  | .||.|||
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

K---MIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTpLMNFIRTVK
    . .|.. |.||.   .  . .| . .  |..  .|  ...  | .. .|||   .. . ...|
treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyed.flalrkvmk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 357-528 2.1e-20 67.4 In-house 99-280 (302) alignment 
Range on Protein: 357-528
Range on HMM: 99-280/302.0
PNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---KMIYGKITVTRKSEEVNT-HY----TVRTFSVVF-----GDNIREVV-QFHYTSW
|   ... .| .. . . . .| |.. ||.|..|| .|. ||   .. .|. ||. .| . .  ..    ... ..| .      .. .  |  .....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDMGVPKYTTPLMNFIRTVKQHHTNsvgaIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFI
|| | || . . .. ..  . . .|    ..||||||||||||....   ..    ..  |. . .. .|| |   || ..|  ..
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Ptp69D_pd Subfamily Ptp69D 566-667 2.7e-20 67.7 In-house 23-122 (307) alignment 
Range on Protein: 566-667
Range on HMM: 23-122/307.0
LLQEQFERLDMFtikPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
.|.. .|.|        | . ... .  |  ||||.|  . || |  |  .. .. ..||||||. || .|  |.  | |. .|.|||||.. . .. .|
glakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

IML
.||
vml
subfamily_CG7180_pd Subfamily CG7180 582-667 9e-20 65.5 In-house 30-116 (296) alignment 
Range on Protein: 582-667
Range on HMM: 30-116/296.0
RDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
. .. ... .. |  |||. . .| |. |..| . . |. ..||||..  ...||  .. |..|  .||..|||||.| .||....|
eigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvL
0037934 (Phosphotyrosine protein) phosphatases II 589-668 4e-19 64.6 In-house 5-80 (243) alignment 
Range on Protein: 589-668
Range on HMM: 5-80/243.0
ARNSMNVHKNRYHDKLPTDKSRPYLiteveNGTNYINASFLPGYtkkDMFLGTQTPLPNTVGD----FWRLVFDYKISTIIMLN
|.  .|..|||| | || | || .|     .|..||||.. ...   . .  || |||.|| |    |||......|..|.||.
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmlt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 564-668 5.9e-19 62.7 In-house 19-120 (392) alignment 
Range on Protein: 564-668
Range on HMM: 19-120/392.0
STLLQEQFERLDMFTIKPRddelRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
|.|. |.|  |    | |.    ..|.. .|..||||.. || |..|  | . .  . ..|.|||..|..  .  .. .|.| . .. ||||.||. ...
salffeefhdlpgpdiypq....tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

TIIMLN
||.|..
tiamvt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 583-667 6.9e-19 63.0 In-house 30-115 (281) alignment 
Range on Protein: 583-667
Range on HMM: 30-115/281.0
DDELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
|.  . ...  ||.||||..    |..|  .  .| .. |.||||.|.|||...  .. ||.|.|... .||..|...|.|.|.|.
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 553-667 9.4e-19 62.5 In-house 8-117 (287) alignment 
Range on Protein: 553-667
Range on HMM: 8-117/287.0
PSLLAPSPDTGSTLLQEQFERLDMFTikPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDF
  . |  ...|..  ..||  |.  |   |.||.  .  | | .|||... |. |. |  |    ..  .||||.|. || .|  |. ...|. ||. .|
gefvakghakgnegfknqftvleqvt..qredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnf

WRLVFDYKISTIIML
|.|. | ....|.||
Wkliddrnvtaivml
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 360-533 1.2e-18 62.1 In-house 39-218 (255) alignment 
Range on Protein: 360-533
Range on HMM: 39-218/255.0
ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEVNTHYTVRTFSVVFG--DNIREVVQFHYTSWPDMGVPKYTTPL
 .|. |....   .  ..|||..  | .. ||..|.|   |.|... ...||      .     ..    .|   . ..|  ..|. |..   |. .  .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

MNFIRTVKqhhtNSvGAIVVHCSAGVGRTGTFITLDAMLD-------QAEAeNAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
.| .. |.    .|  ..|||||.|.||. .|.  . .         ..|.   .|  .... .|..| . ..   |  |    .|
lnilkvvr....ds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 414-536 1.3e-18 61.9 In-house 198-344 (350) alignment 
Range on Protein: 414-536
Range on HMM: 198-344/350.0
VNTHYTVRTFSVVFGDNIReVVQFHYTSWPDMG---VPKYTTPLMN----FIRT--VKQHHTNS-VGAIVVHCSAGVGRTGTFITLDAMLD-------QA
.. ....    .   |    | |...  |.|..    |.   . ..    .| .   ..|  |.   .|.||||||||||||..||| .|          
lkdnnsltaitlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenlt

EAENAIDVYN--------FITGMRQNRIKMVQVAEQYQFIYDALLETF
.  . .|| .         .  .|. ||.|||  .|. |||.|||  |
kesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 592-667 9.4e-18 59.3 In-house 26-104 (274) alignment 
Range on Protein: 592-667
Range on HMM: 26-104/274.0
SMNVHKNRYHDKLPTDKSRPYLITEVEN--GTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
. . .||||.. || ..||  | .|  .   ..|||| .. || . . ... || |||||| ||||...  ... |.||
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml
subfamily_PTPN23_pd Subfamily PTPN23 563-667 1.2e-17 58.7 In-house 13-114 (288) alignment 
Range on Protein: 563-667
Range on HMM: 13-114/288.0
GSTLLQEQFERLDMFTIKPrDDELRTARNSMNVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTKK-DMFLGTQTPLPNTVGDFWRLVFDYKI
| | |...|. |..   |    .  .|   ....|||..| || |..|  |    ..  .||||||. . .     |. ||.||..|..|||..|.. | 
gktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

STIIML
|.|.||
sviVml
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 568-667 4.8e-17 56.8 In-house 9-106 (283) alignment 
Range on Protein: 568-667
Range on HMM: 9-106/283.0
QEQFERLDMFTIKPRDDELRTARNsmNVHKNRYHDKLPTDKSRPYLITEVEngtNYINASFLP---GYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
. ..|.|. ... ..| .. .|..  | .|||... .|.|. |  | .| .   .||||.|.|    | ..  .. .|.|| .|| |||..||| ||..|
klfrevlkrlsvpdldadiasade..nkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

IML
.||
vml
subfamily_PTPN6_pd Subfamily PTPN6 561-667 5.6e-17 56.7 In-house 22-129 (306) alignment 
Range on Protein: 561-667
Range on HMM: 22-129/306.0
DTGSTLLQEQFERLDMFTIKPRDDElRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLPGY--TKKDMFLGTQTPLPNTVGDFWRLVFD
... . ..|.||.|.    | . .  . ..   | .||||.  || |..|  |  .   |..||||... .   ...  .. ||  |..|| ||||.|..
slekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

YKISTIIML
 .   |.|.
ensrvivmt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 562-667 2.6e-16 54.4 In-house 17-122 (290) alignment 
Range on Protein: 562-667
Range on HMM: 17-122/290.0
TGSTLLQEQFERLDMftiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVEN---GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFD
.| .  ..||..||      .. .  ..  | | ..||... ...|  |  |    ..     .||||... || .|  .. ||.|..||. |||.|. .
kgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

YKISTIIML
 |.. |.||
ekvtiivml
subfamily_PTPN3_pd Subfamily PTPN3 569-667 2.7e-16 54.3 In-house 19-115 (280) alignment 
Range on Protein: 569-667
Range on HMM: 19-115/280.0
EQFERLdmFtIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiteVENGTNYINASFL----PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
 |||.|  .  | .. .. .|| . |..||||.| || |. |  |   .|. |.||||...    |. .    .. || ||..|. |||..|.. |.|.|
aqfeql..y.rkkpglaisaarkpenlsknryrdilpydatrvkl...kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

IML
.||
vml
subfamily_CG42327_pd Subfamily CG42327 462-532 3.8e-16 53.6 In-house 240-311 (319) alignment 
Range on Protein: 462-532
Range on HMM: 240-311/319.0
KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE-NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDAL
.  . .| | .||||| ||||||. |. |  . . |   ...|. . .  .|..| . |.  |||.|||  |
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 568-667 6.2e-16 53.2 In-house 9-103 (267) alignment 
Range on Protein: 568-667
Range on HMM: 9-103/267.0
QEQFERLDMftIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENgtnYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
...|| ..   | .    . .   . |  .||. |.|| |..|  | |. |.   |||||.. || .| .|. || || ||..||. .. |.|...|..|
ekefelikk..isdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll
subfamily_PTPN14_pd Subfamily PTPN14 577-667 6.8e-16 53.1 In-house 32-124 (300) alignment 
Range on Protein: 577-667
Range on HMM: 32-124/300.0
FTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLP--GYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 . |  | .| ||..  |..|||..| || ...|  |..  || |.||||| .     .|.  .. .|.||..|| |||..|.. ... |.||
ipkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 566-667 1.5e-15 51.7 In-house 16-116 (301) alignment 
Range on Protein: 566-667
Range on HMM: 16-116/301.0
LLQEQFERLDmftiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE---NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
 ..||...|.    . .|..     ...| . ||...  . |. |  | .. .     ..|||||.. ||..|  |  .| |. .|. |||||....| .
kfeeqykelk....egedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIIML
.|.|.
sivmv
subfamily_PTPN13_pd Subfamily PTPN13 575-667 1.5e-15 52.2 In-house 19-108 (273) alignment 
Range on Protein: 575-667
Range on HMM: 19-108/273.0
DMFTIKPRDdELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVEngtnYINASFLPGYTKKDMF--LGTQTPLPNTVGDFWRLVFDYKISTIIML
..  .|| | . .....  | .||||.. || |..|  |  |      |||||..     || .  . .| |||.|| |||..|.. | . |.|.
elrelkpld.tcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 472-537 1.6e-15 51.2 In-house 1-66 (69) alignment 
Range on Protein: 472-537
Range on HMM: 1-66/69.0
IVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFV
.|||||.| |||||||..   . .  .|  .|..| .  ||. |  ||    .| ||.||| |.. 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_hpo-7_pd Subfamily hpo-7 359-533 2e-15 51.4 In-house 44-224 (263) alignment 
Range on Protein: 359-533
Range on HMM: 44-224/263.0
VASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEVNTHYTVRTFSVVFG--DNIREVVQFHYTSWPDMGVPKYTTP
|  .. |....      ..|||..  | .. ||..|.|   |.|... ...|.      ..    . .  ..|   ....| .. |. |..   |. .  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

LMNFIRTVKqhhtNSvGAIVVHCSAGVGRTGTFITLDAMLD-------QAEAeNAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
 .| .. ..    ||   .|||||.|.||.  |   . .         ....   .|  .... .|..| . ..   |  |    .|
ilnilkvar....ns.kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 473-539 2.6e-15 50.5 In-house 1-67 (69) alignment 
Range on Protein: 473-539
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCG
|||||.| |||||||..   . .  .|  .|..| .  ||. |  ||   ..| ||.||| |..  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 297-408 3.1e-15 50.4 In-house 39-164 (349) alignment 
Range on Protein: 297-408
Range on HMM: 39-164/349.0
PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPH--------------SDYVNANFID--GYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVML
 . ... .|   |||| .|. |.||||.|.   . ..               ||.|||..    ..  ..||| | |  ..|.||....  .    .. |
dvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TNTVEGEKRKCEKYWPDKKmiYGKITVT
..  | . .||..|| . .  |  ||| 
nddkelslekcdiywqels..ysnitvk
0041856 (Phosphotyrosine protein) phosphatases II 594-668 4.3e-15 51.2 In-house 1-66 (182) alignment 
Range on Protein: 594-668
Range on HMM: 1-66/182.0
NVHKNRYHDKLPTDKSRpylitevenGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
|..|||| | || | ||         . .||||... |. . . |. ||.||..|| ||.|.. ...|.||..|.
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt
subfamily_PTPN1_pd Subfamily PTPN1 585-668 4.7e-15 50.1 In-house 23-103 (290) alignment 
Range on Protein: 585-668
Range on HMM: 23-103/290.0
ELRTARNSMNVHKNRYHDKLPTDKSRPYLITEvENgtNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
. |.|..  |  .||| |  | |.||  |  . .|  .|||||..     |  .. || ||||||. ||..|.. |  ...|||
ptreaklpenrnlnryrdvspydhsriklera.dn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmln
0049772 (Phosphotyrosine protein) phosphatases II 586-666 2e-14 49.5 In-house 38-126 (314) alignment 
Range on Protein: 586-666
Range on HMM: 38-126/314.0
LRTARNSMNVHKNRYHDKLPTDkSRPYLITEVENGTNYINASFLPGYtKKdmFLGTQTPLPNTVGDF----------WRLVF--DYKISTIIM
. .|.  .| .||||.| || | .|  | ..  .|..|||||.. |. .|  |. ||.||..|| ||          ||.|.  |... .| |
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lk..fIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm
subfamily_ptpA1_pd Subfamily ptpA1 590-667 4.7e-14 46.9 In-house 43-120 (418) alignment 
Range on Protein: 590-667
Range on HMM: 43-120/418.0
RNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDmFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 .  |  |||| . || ...|  |   . ..|..|||| .. |   |. |. || |||||. ||||.|.. .   |.||
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivml
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 261-345 5e-14 46.5 In-house 4-86 (440) alignment 
Range on Protein: 261-345
Range on HMM: 4-86/440.0
QPIPLDQLITYVAQKKAStkNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGY
.|| . ..  || ... |    |....  .| |  .| |.|   .|| |||| ||.||||||| |  ..  |.|||.|| .|.| 
rpiivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 462-536 5.3e-14 46.3 In-house 258-344 (349) alignment 
Range on Protein: 462-536
Range on HMM: 258-344/349.0
KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLD----QAEAENAIDVYNF--------ITGMRQNRIKMVQVAEQYQFIYDALLETF
.  .|. . ...|||||| ||||...||| .|.      .  | |.. .         .  .|. || |||   |. .||.|||. |
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 567-667 6.2e-14 46.3 In-house 22-122 (439) alignment 
Range on Protein: 567-667
Range on HMM: 22-122/439.0
LQEQFERLDmfTIKPR-DDELRTARNSMNVHKNRYHDKLPTDKSRPYL--ITEVEnGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIST
..| || ..  ...|    .   | .. .  ||||.|  . | .|  |  |  |   . |||| .. || ...... ||.|  .|. ||||||.. | .|
fkeifekin..stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp.hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IIML
|.||
ivml
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 631-668 8.4e-14 45.7 In-house 231-268 (440) alignment 
Range on Protein: 631-668
Range on HMM: 231-268/440.0
GYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
||.||. |. || ||  || |||||| ||.||||||||
gyskknafiatqmpldstvldfwrlvhdyristiimln
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 593-667 1e-13 45.9 In-house 19-95 (270) alignment 
Range on Protein: 593-667
Range on HMM: 19-95/270.0
MNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGYTKK-DMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 . . |||.| ||. ..|  | ..  .. |.|||| ...|....   .. ...|||.|. .|||.... | ..|.|.
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 262-356 2.1e-13 44.2 In-house 4-95 (95) alignment 
Range on Protein: 262-356
Range on HMM: 4-95/95.0
PIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLpllENDPHSDYVNANFIDGYNYPRRYIAAQG
|| .  . ..| . .. . . | ... ||.     |  |     |  |||..||. || .|| |        |||.|| |.|||     ||||||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 460-534 3e-13 44.3 In-house 220-293 (297) alignment 
Range on Protein: 460-534
Range on HMM: 220-293/297.0
TVKQHHTNSVgAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
... ..  ..  ..|||||||||.|  .  |..|..   .   ||  ... .|..| ..||  ||....||| |.
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPRN_pd Subfamily PTPRN 567-667 1.8e-12 41.6 In-house 31-131 (297) alignment 
Range on Protein: 567-667
Range on HMM: 31-131/297.0
LQEQFERLDMFTIKPRDDElrTARNSMNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGY-TKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
|....| |  .  .|.  |  .|..  ||.|||... || |.||  | .|  .. ..|||||..     .. ... ||.||..|| |||..|..  .  |
lekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

IML
..|
vnl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 582-667 3.4e-12 40.5 In-house 40-125 (310) alignment 
Range on Protein: 582-667
Range on HMM: 40-125/310.0
RDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
.|  |       ..||||| | .  |.||  |  .     .|| | ..     .. |. .| ||  |. ||||..|. .  .|..|
qdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 300-391 1.1e-11 38.8 In-house 28-118 (332) alignment 
Range on Protein: 300-391
Range on HMM: 28-118/332.0
VAKKIENKQKNRYINIIAYDHSRVQLplLENDPHSDYVNANFIDGYNYPRRYIAAQGPNV-ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKC
  | ..| . ||   . ..|||||.|    .| . |. ||...|||.    || || |    .   ||||| |     |... .  | .|||.
ydkflnnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 581-667 1.3e-11 38.9 In-house 20-107 (297) alignment 
Range on Protein: 581-667
Range on HMM: 20-107/297.0
PRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLItEVENGTNYINASFL--PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 | ... .|. .  ..||||.| | ||..|  |   |  ...|||| ..  |   ..  .. .| || .|| |||.||..  . .|.|.
argesfssakrnsslrknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 343-437 7.7e-11 36.0 In-house 230-323 (440) alignment 
Range on Protein: 343-437
Range on HMM: 230-323/440.0
DGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTvegEKRKCEKYWPD--KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQF
.||     .||.| |  ..| ||||.| .     |.|| .    . . |  |||   . . .| .||  |  |      |||. . . ... |. ||
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 583-667 1e-10 36.1 In-house 30-113 (307) alignment 
Range on Protein: 583-667
Range on HMM: 30-113/307.0
DDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEvENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 . . .   | | .||||.|    ||.|  . ..    ..|| | .|   .|   |. .| || ||. .|| .. . |. ..|||
pegvtveafsantdknryqdvkcqdkgrivvkfd.glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 555-667 1.1e-10 35.5 In-house 57-168 (244) alignment 
Range on Protein: 555-667
Range on HMM: 57-168/244.0
LLAPSPDTGSTLLQEQFERLDMFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWR
.|. |   ||  .. .. .     |.|    .. | |  | .|||    || | .|  | ..   |  ||||||.    .   .. || || .|  |||.
ilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvpl.skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwk

LVFDYKISTIIML
.... ..  ...|
mmlerhvnvlvvl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 593-667 1.4e-10 35.3 In-house 55-125 (290) alignment 
Range on Protein: 593-667
Range on HMM: 55-125/290.0
MNVHKNRYHDKLPTDKSRPYLiTEVENGtNYINASFLPGytKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 ...||||.|    ||.|  |  .  .| .|. | .. |   | ||. || .| .|| |.||.| . |...|.||
tefkknrykdvvcndktrvil.kdGydG.dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivml
subfamily_PTPDC1_pd Subfamily PTPDC1 423-529 2.3e-10 35.2 In-house 71-169 (182) alignment 
Range on Protein: 423-529
Range on HMM: 71-169/182.0
FSVVFGDNIREVVQFHYTSWPDMGVPKYTTpLMNFIRTVKQHHTNSvgAIVVHCSAGVGRTGTFITLDAMLDQ-AEAENAIDVynfitgMRQNRIKMVQV
||  . .  .. . ..  .|.| ||.  .. ... .. |..  ..   .. ||| || ||||  |.   .  .  .||.||..      .|..| | .| 
fsYdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaikl......vrskrpksiqt

AEQYQFIY
 || ... 
reqvelvk
0038934 (Phosphotyrosine protein) phosphatases II 433-528 4e-10 35.1 In-house 78-172 (194) alignment 
Range on Protein: 433-528
Range on HMM: 78-172/194.0
EVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSV-GAIVVHCSAGVGRTGTFITLDAML-DQAEAENAIDvynFITGMRQNRIKMVQVAEQYQFI
  ....   .|| |..  .  |..|.. |.... ..  |...||| ||.|||||..    .   .  || ||.   ... .|.. |  ..  |...  
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAia...lfrekRpgaipnqdyleallkr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 584-667 4e-10 33.9 In-house 38-119 (305) alignment 
Range on Protein: 584-667
Range on HMM: 38-119/305.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYLitEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
. ... ... . .||||.|    |. |  |  |     .|| | ..   |.   |. ||.|| .|  ||| . .. |. .|.||
ekmkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml
0051429 (Phosphotyrosine protein) phosphatases II 620-667 4.1e-10 35.3 In-house 3-52 (272) alignment 
Range on Protein: 620-667
Range on HMM: 3-52/272.0
GTNYINASFLPGYTK---KDMFLGTQTPLPNTVGDFWRLvFDYKISTIIML
 ..||||....||..   ..... .. |||.|. |||||  ...|.||..|
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdL
subfamily_eak_pd Subfamily eak 462-535 4.4e-10 33.5 In-house 229-304 (332) alignment 
Range on Protein: 462-535
Range on HMM: 229-304/332.0
KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLD--QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
| .||    | .. .. |  |.|.|. .| ..   ..  .|.  | ..|  ... ||. | || |. |||...|. 
kyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_egg_pd Subfamily egg 565-668 4.8e-10 33.6 In-house 11-115 (307) alignment 
Range on Protein: 565-668
Range on HMM: 11-115/307.0
TLLQEQFERLDMFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLitEVENGT---NYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKI
...||   || .      .  |.|| .. | .| | .     | ||  |  |...|    ..| |  . |    . |. .|.|| ||| ||||.||  ..
eivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeev

STIIMLN
  |.||.
qyivmlt
0043147 (Phosphotyrosine protein) phosphatases II 619-668 1.2e-09 33.6 In-house 3-52 (172) alignment 
Range on Protein: 619-668
Range on HMM: 3-52/172.0
NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
.|..|||||.|..| . | |. || ||.||. ||||.. ...|..|..|.
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnlt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 594-667 2.7e-09 31.6 In-house 3-76 (237) alignment 
Range on Protein: 594-667
Range on HMM: 3-76/237.0
NVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
|  |||| .    |.||  |     .|..||||..| |.      .. .| || ..  |||..|.. | | |.||
nkiknrygnivaydhsrvvl.kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivml
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 561-667 2.9e-09 31.0 In-house 20-127 (305) alignment 
Range on Protein: 561-667
Range on HMM: 20-127/305.0
DTGSTLLQEQFERLDMFTIKPRDDELRTARNSM--NVHKNRYHDKLPTDKSRpYLITEVEnGTNYINASFLPGY-TKKDMFLGTQTPLPNTVGDFWRLVF
| |   |.|.| .|  .|     . .  | .|   .. ||||.|    |.|   .. .    ..|| | ..      .  |. .| || .|. .|| .| 
dvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsa.vkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmvi

DYKISTIIML
. |.  |.||
qnkveqivml
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 584-667 3.7e-09 30.8 In-house 40-121 (301) alignment 
Range on Protein: 584-667
Range on HMM: 40-121/301.0
DELRTARNSMNVHKNRYhDKLPTDKSRPylITEVENGTN-YINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
|..  .   .. .|.|| ...| . |    .  ...|.   | | ..|   . . |. ||.||.||  ||| ..  |.. .|.||
dhitesyaylpkdkhry.ptvPckPsta..vevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivml
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 592-667 4.3e-09 30.4 In-house 45-114 (303) alignment 
Range on Protein: 592-667
Range on HMM: 45-114/303.0
SMNVHKNRYHDKLPTDKSRPYLiteveNGTNYINASFLPGYTKKDMFLgTQTPLPNTVGDFWRLVFDYKISTIIML
  |..|||. | .  |.|.  |       . || ||.|   ..|   | || ||. |  |||... . |.  ...|
vknmdknrfvdvicldhskvkl.....sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 594-668 4.8e-09 30.4 In-house 47-136 (350) alignment 
Range on Protein: 594-668
Range on HMM: 47-136/350.0
NVHKNRYHDKLPTDKSRPYLI---------TEVENGTNYINASFLP----GYTKKDMF--LGTQTPLPNTVGDFWRLVFDYKISTIIMLN
   ||||.. || ..||  |              .. .||||..|     .   .  |  . ||.|||.|| ||.....  |.  |..|.
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 303-450 7e-09 28.8 In-house 24-157 (169) alignment 
Range on Protein: 303-450
Range on HMM: 24-157/169.0
KIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNAnfidgynyprryiaaqgpnvasvkdfwRMVWEEDCGKIVMLTNTVEGEKRKCE--KYWPDKKM
   |. |||    .|  | ||.|  . .|  |||.||                           ||.|| .   ||.| .| . .    |   |     .
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpav

IYGKIT----------VTRKSEEVNTHYTVRTFSVVFGDNIR-EVVQFHYTSWPDMGVPKY
| |.            |. ... |.  . |      . |..  ..  .||..||. |||. 
ilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 303-450 9e-09 28.4 In-house 23-156 (169) alignment 
Range on Protein: 303-450
Range on HMM: 23-156/169.0
KIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNAnfidgynyprryiaaqgpnvasvkdfwRMVWEEDCGKIVMLTNTVEGEKRKCE--KYWPDKKM
   |. |||    .|  | ||.|  . .|  |||.||                           ||.|| .   ||.| .| . .    |   |     .
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpav

IYGKITV------TRKSE----EVNTHYTVRTFSVVFGDNIRE-VVQFHYTSWPDMGVPKY
| |.         | | .     |.  . |      . |.. | .  .||..||. |||. 
ilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 347-533 9e-09 28.4 In-house 113-306 (346) alignment 
Range on Protein: 347-533
Range on HMM: 113-306/346.0
YPRRYIAAQGP---NVASVKDFWRMVWEEDCgKIVMLTNTVEGEKRKCEKYWPDKKMIY---GKITVTRKSEEVNTHYTVRTFSVVFGDNIREVV-Q-FH
. .. | || |   | . |.||| |...|.  ..| |    .  |      . |..  |   ||. .  .  .|       |  |.   |   |. |  |
fehklivaqlpqmenesfvedfwymiyqeqi.hlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhh

YTSWPDMGVPKYTTPLMNFIRTVKQH-HTNSVGAIVVhCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
.. |  .  |  | |....|   .     ...|  ||    | ||. .||     ..| .     .... .  ..|.|   |.   ||  ||  ..
hapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 584-667 2.8e-08 27.8 In-house 27-112 (281) alignment 
Range on Protein: 584-667
Range on HMM: 27-112/281.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYLIT--EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
|   .  . .| .|||| .    | ||  |      .| |.|| | ..     |  .. || |  .|  ||||.... . ..|.||
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 589-667 3.7e-08 27.8 In-house 3-83 (239) alignment 
Range on Protein: 589-667
Range on HMM: 3-83/239.0
ARNSMNVHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
|.. .|  |||| . .  |.||  |     .  ..|||||.|  |      .. ||  .  . |||||.... .   |.||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 566-668 4.4e-08 27.5 In-house 13-114 (288) alignment 
Range on Protein: 566-668
Range on HMM: 13-114/288.0
LLQEQFERLDM-FTIKPRDDELRTARNSM-NVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIST
.||  .| |.  .   | .   ... . . |  ..||..    | .|  |    ..   ||.|  ..    |  .. .|.||  |.. .|.....  .  
vlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdvey

IIMLN
|.||.
ivmlc
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 589-667 4.7e-08 27.5 In-house 2-82 (239) alignment 
Range on Protein: 589-667
Range on HMM: 2-82/239.0
ARNSMNVHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
|.. .|  |||| . .  |.||  |     .  ..|||||.|  |      .. ||  .  . |||||.... .   |.||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml
0046846 (Phosphotyrosine protein) phosphatases II 611-668 5.1e-08 28.4 In-house 2-55 (176) alignment 
Range on Protein: 611-668
Range on HMM: 2-55/176.0
PYLITEVENGTNYINASFLPGYtkkdMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
.....  ... .||||... |.    ... || |||.|. ||........|.....|.
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlt
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 317-444 5.6e-08 27.2 In-house 4-123 (130) alignment 
Range on Protein: 317-444
Range on HMM: 4-123/130.0
AYDHSRVQlpllendpHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTnTVEGEkrkcEKYWPDKKMIY---GKITVTRKSEE
 .. ||.|          .|.||.|.   .  . |. .| |  ..  |||.|. |     .|.|  .|| |    ..|||| . .     .|.||    .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpdsePlewyeediivtltdrd

vnTHYTVRTFSVVFGDNIRE----VVQFHYTSWPD
      ...  .   ... |    .  |. . || 
..efknikasnleiesdlneshqaltmfqisnwps
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 594-666 5.9e-08 26.6 In-house 37-115 (347) alignment 
Range on Protein: 594-666
Range on HMM: 37-115/347.0
NVHKNRYHDKLPTDKSRPYLITE------VENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIM
.. ||| .|.  .|..|  |  |       ..  .||||| .     .  .. || |||.|| |||..|.  |.. .. 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 593-667 6.4e-08 26.9 In-house 34-106 (285) alignment 
Range on Protein: 593-667
Range on HMM: 34-106/285.0
MNVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
 |   ||| |    ...|  |    .   .|| ||..    | .  .. || |||.|. |||..... ||. ..||
anpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlml
subfamily_CG42327_pd Subfamily CG42327 595-667 7e-08 26.5 In-house 29-103 (319) alignment 
Range on Protein: 595-667
Range on HMM: 29-103/319.0
VHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTKK-DMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
  |.|. . .|  ..|. |     .. ..|..||.. || .    ....|..| ..  ||||.|.. .  .|. |
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivql
subfamily_PTEN_pd Subfamily PTEN 454-529 2.1e-07 26.1 In-house 98-173 (184) alignment 
Range on Protein: 454-529
Range on HMM: 98-173/184.0
LMNFIRTVKQHHT-NSVGAIVVHCSAGVGRTGTFITLdAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIY
| .........   ..   .|||| || ||||. |.   .| .   |.| .. .. . .| .  | |..  |  ...
leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve
0036282 (Phosphotyrosine protein) phosphatases II 620-668 2.2e-07 26.2 In-house 1-44 (174) alignment 
Range on Protein: 620-668
Range on HMM: 1-44/174.0
GTNYINASFLPGYTKKDMFLGTQTPLPntvgdFWRLVFDYKISTIIMLN
|..|||||.| ..   . .. .| ||.     ||.......|.|..||.
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmll
0048567 (Phosphotyrosine protein) phosphatases II 429-520 4.4e-07 24.4 In-house 25-126 (157) alignment 
Range on Protein: 429-520
Range on HMM: 25-126/157.0
DNIREVVQF-------HYTSWPDMGvPKYTTPLMNFIRTVKQHH---TNSVGAIVVHCSAGV---GRTGTFITLDAMLDQAEaeNAIDVYNFITGMRQNR
... ....|       ... . | | |   . |..||. ...     ..  .||.|||.||    |||.|.| . ..| .    .. ......  .|.. 
kslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf..tpeeaiaplrivrpgs

IKMVQ
.   .
vpfrd
subfamily_CDC14_pd Subfamily CDC14 452-492 5.3e-07 23.8 In-house 246-286 (328) alignment 
Range on Protein: 452-492
Range on HMM: 246-286/328.0
TPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAM
||  . ..   .   .. |||.||| ||.|||||.|.   |
tPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylm
PTPc_motif_SM00404 448-518 5.5e-07 24.5 In-house 63-123 (140) alignment 
Range on Protein: 448-518
Range on HMM: 63-123/140.0
PKYTTPLMNFIRTVkqhhTNSVGAIVVHCSAGVGRTGTFITLDAMldQAEAENAIDVYNFItgmRQNRiKM
 ||   ...||...    ... |...||| ||| |..|.|.   |  . .  .. ..|.|.   ...| ..
skyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefv...kerR.pi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 387-535 6.8e-07 23.1 In-house 146-301 (332) alignment 
Range on Protein: 387-535
Range on HMM: 146-301/332.0
EKRKCEKYWPDKKM--IYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMG-VPKYTTPL-----MNFIRTVKQHhTNSVGAIVVHCSA
. . | |.||.|.    .  ...    .  .||     ..|    . .. | .|.  | |   .|.|   .     ...||. |.     .| |.. |..
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskkt.gvcigpimlvcat

GVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
|| .   . |.| .. .   |  . . . .. .. .|.  ..    |    . |.. 
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf
0049260 (Phosphotyrosine protein) phosphatases II 628-668 7.5e-07 24.5 In-house 1-41 (152) alignment 
Range on Protein: 628-668
Range on HMM: 1-41/152.0
FLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
|..|| .. .|..|| |.|||. ||||.. ...|.||.||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmlt
PTEN_1 433-487 7.7e-07 24.1 In-house 93-148 (196) alignment 
Range on Protein: 433-487
Range on HMM: 93-148/196.0
EVVQFHYTSWPDMGVPKYTtPLMNFIRTVKQHHT--NSVGAIVVHCSAGVGRTGTFI
. |...  ...| |.|     |. ... ...     .. ....||| ||.||.|| .
sgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 306-383 1.2e-06 22.3 In-house 37-119 (347) alignment 
Range on Protein: 306-383
Range on HMM: 37-119/347.0
NKQKNRYINIIAYDHSRVQLP-----LLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNT
. .|||  .    | .|| |        . |.   |.||  |   |  . || .| |   .|.|||.||      ..| . . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 592-642 2.3e-06 21.7 In-house 46-94 (95) alignment 
Range on Protein: 592-642
Range on HMM: 46-94/95.0
SMNVHKNRYHDKLPTDKSRPYLITEVEngTNYINASFLPGYTKKDMFLGTQ
  |. |||. . .| | .|  | |  .  ..|||| |. ||..|. .. .|
eanipknrflnifpydatrvvlttkrd..sdyinacfvdgyarkncyiaaq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 620-668 2.9e-06 20.8 In-house 89-139 (349) alignment 
Range on Protein: 620-668
Range on HMM: 89-139/349.0
GTNYINASFL--PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLN
  .|||| .|  . .. .  .. || ||| || ||....   ..  .. ||
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn
subfamily_DSP23_pd Subfamily DSP23 442-530 3.3e-06 21.8 In-house 54-140 (148) alignment 
Range on Protein: 442-530
Range on HMM: 54-140/148.0
WPDMGVPKYTTP----LMNFIRTVKQHHtNSVGAIVVHCSAGVGRTGTFITLDAMLDQAeaenaIDVYNFITGMRQNRIKMVQVAEQYQFIYD
.  .... |. |    . .|.| |.. . .   |. |||  | |||||...   .  .      .   . |. .|. |   |.  || . ..|
lvrlriddyhppaleqvvefvrvveeae.ekneavsvhcllgrgrtgtmlacylvkerk.....laaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 305-345 3.4e-06 20.9 In-house 38-77 (244) alignment 
Range on Protein: 305-345
Range on HMM: 38-77/244.0
ENKQKNRYINIIAYDHSRVQLPLLENDpHSDYVNANFIDGY
 |  |||||||. .|..|| |   ...  |||.|||.|.| 
anatknryinilpfdetrvilssskke.gsdyinanyiqgs
DSPc Dual specificity phosphatase, catalytic domain 449-515 3.4e-06 22.0 Pfam-A 57-114 (133) alignment 
Range on Protein: 449-515
Range on HMM: 57-114/133.0
KYTTPLMNFIRTVkqhhTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEaeNAIDVYNFItgmRQNR
|.   ...||...    ... . ..||| ||. |..|.|.   |  .    .. . |.|.   ...|
keleeavefieka....eqkgkkvlVHCqaGisRSatliiaYlmktknl..slneAyefv...kerr
DSPc Dual specificity phosphatase, catalytic domain 449-515 3.4e-06 22.0 In-house 57-114 (133) alignment 
Range on Protein: 449-515
Range on HMM: 57-114/133.0
KYTTPLMNFIRTVkqhhTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEaeNAIDVYNFItgmRQNR
|.   ...||...    ... . ..||| ||. |..|.|.   |  .    .. . |.|.   ...|
keleeavefieka....eqkgkkvlVHCqaGisRSatliiaYlmktknl..slneAyefv...kerr
subfamily_DSP19_pd Subfamily DSP19 441-488 9.1e-06 20.1 In-house 65-108 (152) alignment 
Range on Protein: 441-488
Range on HMM: 65-108/152.0
SWPDMGVPKYTTPLMNFIRTVKQHHtnsvGAIVVHCSAGVGRTGTFIT
  |.  . .|    ..||. .....    ||..|||.||| |. ... 
DlpetdllsylkealdFieearskd....gavlvHCnAGvSRsasvvi