Gene SpurPTP-sf4-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP105_AA protein Get Run
SpurP105_AA_2061-2335 phosphatase_domain Get Run
SpurP105_AA_2347-2630 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 2057-2408 9.9e-127 418.9 In-house 3-354 (564) alignment 
Range on Protein: 2057-2408
Range on HMM: 3-354/564.0
PAVKIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
..... ||  .|..  ||... |. .|...  ||  |||.|. ..| .|||| ||..||||||.| . .  .  |||||||. || |.||||||||||..
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEF
|. |||||||.... .|||||||.|..| ||. ||||.  ||||..| |...| .. .|. ||....|. . | | |..||.||||| | | |||.||..
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

ITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQ
|.||.. . . .||..||||||||||||. .||.|..    |.....  .| ..|..|  ||||.|||.||.||.|| | || |.|..... | ...|..
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLae

TNLHTKRTFLEEHLSALDaMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYR
.. .|. | ||     |   .      ...... ..|..|||... ..|.. |
veedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescr
0051299 (Phosphotyrosine protein) phosphatases II 2059-2334 1.5e-100 331.7 In-house 5-286 (288) alignment 
Range on Protein: 2059-2334
Range on HMM: 5-286/288.0
VKIVELSGYVKEKTANGEMCFKLDYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTT
... ||  .|....||| . ..  .|.|.. . ..|. .| ..||..|||| .|.|||||||.| . .. .. ||||||...|| .....|||||||..|
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

VFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP-EDIETYGDFTLTVVAERNYLNYTERTLTIRKA----WDPEERRVQHFHYTSWPDMGLPLSATPL
| |||||||...|.||||||||||....||..||| .. .||||.| | . |  . .|| |||....     .| |.|.|.|||||.|||.| | |...|
vedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
|.|. .|... | ..||..||||||||||||. ..| ....  .|. ..||..| |.|..|  ||||||||.|.||||||.|
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2061-2368 1.7e-100 331.0 In-house 8-313 (315) alignment 
Range on Protein: 2061-2368
Range on HMM: 8-313/315.0
IVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFD
. .|  || .| |. .  || ||| .| ||..  .|| . ||. ||||||||.||.||| |      || ||.||.|. || |.. |||.|||. ..| |
ldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkd

FWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIrkAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVK
|||.|..| .  |||||.|||..|||.. |||..  .|| .|.| . |  . .|| |||..    . . | |  .|||||||||.| ...||...| .||
fwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswpdmgvpkytiplmnlirtvk

EFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQTNLHT
 ..    |. .||||||||||||. |.|...|    |. |.| .|. ..| .|.||||. ||| |||.|||| ..|| ||.  .  .| .  |   .  |
qhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapspdt

KRTFLEEH
  |.|.|.
gstllqeq
0050432 (Phosphotyrosine protein) phosphatases II 2073-2339 4.2e-99 327.0 In-house 38-304 (308) alignment 
Range on Protein: 2073-2339
Range on HMM: 38-304/308.0
ANGEMCFKLDYERLPDGQM-YTWEVATRQENVSKNRYINIIPYDHSRVILdtdpDaPHEDYINASFVSGY--LKPKAYIATQGPLSTTVFDFWRMVWQER
|..   ..  .|.|.. .  ....|| ..||..|||| .|.|||||||.|    | .. ||||||.|.||   .|...|||||||..|| |||||||...
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

VPVIVMLTKLVENKKRKCDPYWPE----DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEar
|.|||||||||||.. ||..|||.    ....||.||.|.. | .. .|| |||....  |.|.|.|.|||||.|||.| | |...||.|. .|...   
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYT
|.||..||||||||||||. ..| ....  .|. ..|.. |...|..|  ||||||||.|.|.|||| |.. .|
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0040438 (Phosphotyrosine protein) phosphatases II 2065-2348 7.4e-98 323.0 In-house 6-290 (317) alignment 
Range on Protein: 2065-2348
Range on HMM: 6-290/317.0
SGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRM
  ...   ... . ..  .|.|.. . .|..|| ..|| .|||| .|.|||||||.|  ..  .. ||||||.|.|. .....|||||||. ||.|||||
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

VWQERVPVIVMLTKLVENKKRKCDPYWP-EDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE
||...| ||||||.|.|....||..||| ..  |||||| |.. |  . ..| |||.. .  |.|.|.|.|||||.|||.|.| | ..||.|. .|.|. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQ
..|.||..||||||||||||. ... |...  .|....| . |...| .| ..|||||||.|.|.|||| |....|..| .  . 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2059-2366 1.3e-96 318.4 In-house 2-312 (318) alignment 
Range on Protein: 2059-2366
Range on HMM: 2-312/318.0
VKIVELSGYVKEKTANGEMCFKLDYERL-PDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTT
... .|   |..  ..||. .. .|||| .. .  |.  .. . |  ||||.||..|||.|| |..  . .  |||||... || . |||||.|.||. |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFI
. |||||||.    ||||||...|. |.|.. |||..  ..||. . ..  | .. .|. |......    |.| |. .||||||| |.| |.. ||...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

TKVKEFE-ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQ
 .|.. .     ||..|||||||||||.. ..|....  . |. ..|...| ..|..|  |||| .||.|||..||| | .| | | .. . .   .|..
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

TNLHTKRTFLE
.. .. .| ..
qdpesgttemd
0046845 (Phosphotyrosine protein) phosphatases II 2082-2340 3e-96 317.4 In-house 5-280 (284) alignment 
Range on Protein: 2082-2340
Range on HMM: 5-280/284.0
DYERLPDGQM---YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDA-PHEDYINASFVSGY-----LKPKAYIATQGPLSTTVFDFWRMVWQERVPV
..|.|.  ..   ....|| ..||.||||| .|.|||||||.|.. ..  .. ||||||.|.||      ..|..|||||||..|| |||||||...|.|
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLTKLVENKKRKCDPYWP--EDIETYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA--RPS
|||||.||||.. ||..|||  ..  |||||| |.. | .. .|| |||....   . |.|.|.|||||||||.| | |...||||. .|.|.     ..
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

GPTIVHCSAGVGRTGTYFTIDSMMDMSAREQ---QINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTS
||..||||||||||||. ..| ....  .|.    ..||. |.|.|..|  ||||.|||.|.||||||.|....| 
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_PTPRG_pd Subfamily PTPRG 2060-2348 2.5e-95 314.8 In-house 2-301 (563) alignment 
Range on Protein: 2060-2348
Range on HMM: 2-301/563.0
KIVELSGYVKEKTANGEMCFKLDYERLPDG---QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHE-DYINASFVSGYLKPKAYIATQGPLS
.. |.. .| .  |.|.. |. ..| |      .  . | . ..||  ||||.||..||.||| |   |.  .. |||||... || | ||.||||||| 
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

TTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRK-----AWD-PEERRVQHFHYTSWPDMGLPLS
.|. |||||.|...| .|||.|.|||...|||| |||.|  |||| ...| ..|     ||.|||.|..       .  .|..|...|||.|||.| | .
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

ATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQ
..| | |. | .  . .  ||..|||||||||||||  .|...    .|...||..|. ..|..|  .||| |||.|...||||... . | . .. . .
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
0043336 (Phosphotyrosine protein) phosphatases II 2060-2332 3.6e-95 313.9 In-house 3-275 (278) alignment 
Range on Protein: 2060-2332
Range on HMM: 3-275/278.0
KIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVF
.. .|  ...|. .|.  ...|..|.|.. . .|...| ..||..|||| .|.|||||||.|. ..  .. ||||||.|.|| .|...|||||||. || 
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKV
|||||||...|..|||||.|||... ||..|||.. .|||||| |.. |  . .|| |||.. .  |.|.| |.|.||..|||.|.| | ..||.|. .|
dFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

KEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.|. . ..||..||||||||||||. ... ....  .|. ..... | ..|..| ..||||.||.|.||||||
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 2057-2355 1.7e-94 311.2 In-house 2-298 (314) alignment 
Range on Protein: 2057-2355
Range on HMM: 2-298/314.0
PAVKIVELSGYVKEKTANGEMCFKLDYERLPDGqmytWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
||... .|   ..   ..    || .|| |..|    |..| ..|| .|||. .|..||.|||.| |  . |. |||||... .| .|.|.|.|||||  
pairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIRK--AWDPEERRVQHFHYTSWPDMGLPLSATPLLE
|| ||||.|..|.   |||||.|||. . ||  ||||| |.|||. ...|      ..  |.....|      | | |..|....||| . | ||| ||.
tvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

FITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
.. .||. ..   |...|||||| |||||. .||...||  ||. ..|   |  .|...| ||.| |||.|||...||. ||| |..|.  .   .    
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

Q
.
r
0047943 (Phosphotyrosine protein) phosphatases II 2071-2334 2.2e-94 311.2 In-house 6-272 (273) alignment 
Range on Protein: 2071-2334
Range on HMM: 6-272/273.0
KTANGEMCFKLDYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILdtdpDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQER
....|  .... .|.|.. . ..|..|| ..|| .|||| .|.|||||||.|    . .. ||||||.|.|| .....|||||||. || |||||||...
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VPVIVMLTKLVENKKRKCDPYWPED----IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR
|.||||||.|||....||..|||..     .|||.|| |.. | .. .|| |||....  ..|.| |.|||||.|||.| | | ..||||| .|... . 
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
   .||..||||||||||||. ..| ..|.  .|....||. |...|..|  ||||||||.|.||||||.|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 2058-2334 1.3e-93 308.3 In-house 6-285 (293) alignment 
Range on Protein: 2058-2334
Range on HMM: 6-285/293.0
AVKIVELSGYVKEKTANGEMCFKLDYERLPD-GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
 .|. .....||...|. .. |. .||.| . |.  . ..|....| .|||| ||.||||||| | .  | ...|||||....||  |. .||||||| .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED--IETYGDFTLTVVAERNYLNYTERTLTIRKawDPEERRVQHFHYTSWPDMGLPLSATPLLE
|| |||||||.... .|||||.|||. | ||. |||.|    .||| ..|.|||... ... |.|.|.|  . |||.|...|.||||| | | ....||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FITKVKEFE--ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
|. .|.|    .  ..|..||||||||||||. ..| ...   .|. .... .|...|..|. .||| .||.||....|. |
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2059-2367 2.2e-93 307.8 In-house 5-316 (319) alignment 
Range on Protein: 2059-2367
Range on HMM: 5-316/319.0
VKIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTV
... ||  ..|.  ..||. .. ... |  ..  |.. |...|| .|||| ||..||..||.| . .. .  |||||||. || . ...||||.||..|.
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

FDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFI
 |||||||.|.. ..||||||||. | |.  ||||   |.|| ...|.  |..  .|  | |...|.  . | |.|.||.||.||| . | .|| ||...
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

TKVKEFEAR-PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQ
 ....   .  ||| .||||||||||||. ..| |..   .|. ..|  .| |.||.|  |||.|||| |||||||| . .| | .  . . . . .|..
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlae

TNLHTKRTFLEE
 .  |  | || 
kvadtgetgler
0036941 (Phosphotyrosine protein) phosphatases II 2082-2343 2.2e-93 308.1 In-house 18-286 (297) alignment 
Range on Protein: 2082-2343
Range on HMM: 18-286/297.0
DYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILdtdpDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLV
 .|.|.. . .....|| ..||..|||| .|.||||.||.|    | .. ||||||.|.||  ....|||||||..|| |||||||...|.||||||.||
efeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelv

ENKKRKCDPYWP---EDIETYGDFTLTVVAERN--YLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR--PSGPTIVH
|. . ||..|||   ..  ||||||.|.. .    . .|| |||.. .  ..|.|.|.|||||.|||.|.| |...||.|| .|... .   ..||..||
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

CSAGVGRTGTYFTIDSMMDMSA---REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPT
|||||||.||. ..| |...     .|.....|..|  .|..|  .|||.|||.|.|||||| |....| .| 
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl
0039614 (Phosphotyrosine protein) phosphatases II 2067-2338 4.8e-93 307.1 In-house 22-293 (297) alignment 
Range on Protein: 2067-2338
Range on HMM: 22-293/297.0
YVKEKTANGEMCFKLDYERLPDGQMYtWEVATRQENVSKNRYINIIPYDHSRVILDTDPDA-PHEDYINASFVSGYLK-PKAYIATQGPLSTTVFDFWRM
... ..||. ....|..|.|.. .   ...| ..||..||||..|.|||||||.| . ..  .. ||||||.|.|| . ....|||||||. || |||||
llllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VWQERVPVIVMLTKLVENKKrKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIRKawDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA
||...|.||||||||||... ||..||||. .|||||| |.. .  . .|| |||....  . |.| |.||.||.|||.| | |.. ||||. .|.|. |
vweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreala

R--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
.  ..||..||||||||||||. ... |...  .|....||. | ..| .| ..||||.||.|.|.|||| |....
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_PTPRA_pd Subfamily PTPRA 2058-2368 6.1e-93 306.3 In-house 13-329 (330) alignment 
Range on Protein: 2058-2368
Range on HMM: 13-329/330.0
AVKIVELSGYVKEKTANGEMCFKLDYERLPDGQM-YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
 . . .|   .. ..|.    |. ... || |..  | |.|...||  |||..||.|||.||||| .    .. |||||||. || . . .||.|||.. 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWD----PEERRVQHFHYTSWPDMGLPLSATP
|| |||||.|. .   |||||.| | |. ||  |||.. . |||. ...|  |    .|| | . ...  |     ..| |. ||.|||||.|.|  .  
tvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFT
.|... |||. . . .|| .||||||||||||. ..|.....   |....| .|| |.|..| .|||| |||.|||..|||  | | | .   .. ... 
mlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

RLEQTNLHTKRTFLEEH
.| ..  .|... ||| 
klynkitgtdkigleee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2066-2341 1.3e-92 305.3 In-house 16-297 (298) alignment 
Range on Protein: 2066-2341
Range on HMM: 16-297/298.0
GYVKEKTANGEMCFKLDYERLPDGQM----YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDF
 ... | ... . ..|...||  ..      ..||| ..|| .|||| .||..|.|||.| .. .  . |||||||...| . .|.||||.|| .|| ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMVWQERVPVIVMLTKLVENKKRKCDPYWPE-DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVK
||||..| . .|||||.|.| .| |.  |||.   ||||..|... .. .. ... |.|.. |.   .||.|...|.||||| | |  || .|....||.
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

EfEARPSG--PTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSV
    . .|  | ||.|||||||.||.  |||...   .|| . |.. | ..|.||...||| ||||||||| || | .. . .
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0045450 (Phosphotyrosine protein) phosphatases II 2063-2335 1.5e-91 302.6 In-house 13-305 (307) alignment 
Range on Protein: 2063-2335
Range on HMM: 13-305/307.0
ELSGYVKEKTANGEMCFKLDYERLPDGQM---YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDA-PHEDYINASFV--------SGYLKPKAYIAT
 |  .|....... . ..  .|.|.. .    .....| ..|| .|||| .|.||||.||.| . ..  .. ||||||.|        .|| .....|||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED--IETYGDFTLTVVAERNYLNYTERTLTIRKA-WDPEERRVQHFHYTSWPDMGLPL
||||. || |||||.|...| ||||||.|||....||..|||..    |||.|| |.. |  . .|| |||..     . |.|.|.|||||.|||.|.| 
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SATPLLEFITKVKEFEAR--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQ---INVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
|  .||.|| .|... ..  ..||..||||||||||||. ... |...  .|.    ...|. | ..| .| ..||.||||.|.|||||| ||
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
DSPc_SM00195 2093-2333 2.2e-90 297.9 In-house 17-261 (263) alignment 
Range on Protein: 2093-2333
Range on HMM: 17-261/263.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
. . | ...|.||||| ||.||||.||.|..... ...|||||....|. |.|.||||||||..|| |||||||.|.|..|||||. .||.|.||| |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

EDI---ETYGDFTLTVVAERNYL-NYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTID
|..   ||.|......| . ..  ... |||...|  . |.|.|....|..||| |.| |....||.. .||. . . |||..||||||||||||. |||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
....  ..|..... . | ..|..| .|||| ||| |||||.||.
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 2093-2333 2.2e-90 297.9 In-house 17-261 (263) alignment 
Range on Protein: 2093-2333
Range on HMM: 17-261/263.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
. . | ...|.||||| ||.||||.||.|..... ...|||||....|. |.|.||||||||..|| |||||||.|.|..|||||. .||.|.||| |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

EDI---ETYGDFTLTVVAERNYL-NYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTID
|..   ||.|......| . ..  ... |||...|  . |.|.|....|..||| |.| |....||.. .||. . . |||..||||||||||||. |||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
....  ..|..... . | ..|..| .|||| ||| |||||.||.
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2060-2346 2.5e-90 297.7 In-house 5-295 (305) alignment 
Range on Protein: 2060-2346
Range on HMM: 5-295/305.0
KIVELSGYVKEKTANGEMCFKLDYERLPDGqMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVF
 . .|. |.||.... .  .. .|. |..    . .| ....|..|||. .|...|..|.|| .... ...||||||.| || . |.||..|||| .|| 
alddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIET---YGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEF
||||....|.| .|||||||||..| ||  |||| .     .|.|....  |... .|.|| |.| .   | |.| | ... |.||| | | .|| ||..
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

ITKVKEFEARPSG-PTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTI
| .|..   .  | | .|||||||||||.. ..| ...   .|....| . . ..|.||.||||| .||||...|| | . ||.||.  . .
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2067-2332 4e-86 283.6 In-house 11-277 (288) alignment 
Range on Protein: 2067-2332
Range on HMM: 11-277/288.0
YVKEKTANGEMCFKLDYERLPD-GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMV
.|..| |...  |. .|. |.  ..  . ... . .| .|||| ||.|||. || |.  .. . .||||||.. |. | |.||||||||  || |||..|
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WQERVPVIVMLTKLVENKKRKCDPYWPEDIE--TYGDFTLTVVAERNYLNYTERTLTIRKawDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE
.....  |||||.|||. |.||. |||.. .   ||..|.|.| ...  ....|.| . |  . .|.......|..|||.| | |..||||....||  .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllek..kkteleitqyqylaWpdhgvPeskapllellrqvkvan

ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
   .|| |||||||||||||. ..| ..|.  .|..|.|...| ..| .|  .||| .||.||||.||.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0040439 (Phosphotyrosine protein) phosphatases II 2093-2334 4.7e-85 280.4 In-house 2-246 (249) alignment 
Range on Protein: 2093-2334
Range on HMM: 2-246/249.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
...|| ..||..|||| .|.|||||||.|   |. .. ||||||...||  ....|||||||. || |||||.|.... ||||||.|||... ||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-EDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR--PSGPTIVHCSAGVGRTGTYFTIDS
 ..  .||||| |.. .  . .|| |||.. .  |.|.|.|.|..||.|||.|.| |  .||.|| .|... ..  ..||..||||||||||||. ... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
|...  .|....... |  .|..| ..||.||||.|.|||||| |
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2078-2409 5.6e-85 280.4 In-house 19-351 (515) alignment 
Range on Protein: 2078-2409
Range on HMM: 19-351/515.0
CFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLT
 |  ..  ||  ..|   ||  . | .|||| ||.||| .||.|.   |.||.||.|||.. ..   |||||.|||. ..| ||||.|.||.|  |.|.|
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

KLVENKKRKCDPYWPE---DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDpeERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHC
|| |. | ||  |||.   |   .| . . .|.     . . |.||. |  |   | |  ||.| ||| | |  .. || .| .||  . . . | |.||
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihc

SAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQTNLHTKRTFLEEHLSALDA
|||||||| . .|||..   .  . ..|..||  .| ||...||| ||| |||.|.|| ||   | .|   . ...  |  .     |. . ..  .| .
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks

MSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRP
.         ..|.. .|| |||| .|.||.. | 
lcpdppasqtrsgrtrdnhpknrygnnlplqrnrv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2096-2336 5.6e-85 279.5 In-house 3-244 (250) alignment 
Range on Protein: 2096-2336
Range on HMM: 3-244/250.0
VATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRkCDPYWP-ED
|| . .|  |||| .||..|.|||.| ..    . |||||||. || . ||.|||||||..|. ||||||..| . .|||||.|.|..|  .  ||| | 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR-PSGPTIVHCSAGVGRTGTYFTIDSMMDM
 |.||| |...  . .. .|| |.| . ||   .|| |...|...||| | |  ||  ||...||.  . .  ..| ||.|||||||.|.. .||.... 
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
  .|....| ... ..|..|...|.. |||||.||..|. | .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
Y_phosphatase Protein-tyrosine phosphatase 2102-2332 8e-85 279.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 2102-2332
Range on HMM: 1-235/235.0
NVSKNRYINIIPYDHSRVILdtDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP---EDIETY
| .|||| .|.|||..|| |  . .  ..|||||..|.|| ..|..|||||||. |. |||||||||.| ||||||.|.|....||..|||   |. .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDFTLTVV-AER-NYLNYTERTLTIRKAWDP-EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA
||......  |  .  .|| |.|...|  .. |.|.|...|||.||| |.| |...||..|.||.. ..  |||..||||||||||||. ..| ....  
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.|....||..| ..|..| .|||. |||.|.|.|.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 2102-2332 8e-85 279.4 In-house 1-235 (235) alignment 
Range on Protein: 2102-2332
Range on HMM: 1-235/235.0
NVSKNRYINIIPYDHSRVILdtDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP---EDIETY
| .|||| .|.|||..|| |  . .  ..|||||..|.|| ..|..|||||||. |. |||||||||.| ||||||.|.|....||..|||   |. .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDFTLTVV-AER-NYLNYTERTLTIRKAWDP-EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA
||......  |  .  .|| |.|...|  .. |.|.|...|||.||| |.| |...||..|.||.. ..  |||..||||||||||||. ..| ....  
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.|....||..| ..|..| .|||. |||.|.|.|.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0045098 (Phosphotyrosine protein) phosphatases II 2081-2337 4.1e-83 274.2 In-house 12-275 (278) alignment 
Range on Protein: 2081-2337
Range on HMM: 12-275/278.0
LDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVIldtdpdapheDYINASFVSGYlkPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLV
  .. |. |.......| . .|..|||| .|.|||||||.          ||||||...||  ||..||||||| .|| |||||.|.....||||||.||
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

ENKKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRKA----WDPEERRVQHFHYTSWPDMGLPLSA--TPLLEFITKVKEFEAR--------
|... ||..||||.  .||||||.|.. | .. .|| |||...       | |.| |.|.||..|||.| | .   ...||..  ..|. ..        
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----PSGPTIVHCSAGVGRTGTYFTIDSMMDMSarEQQINVLDFVYRMRTKRVK-MVQTPEQYVFIYEALLECLLCG
     ..||..||||||||||||.  .. |...   |.....|. |  .|..|   .||..|||.|.||.||| ||.|
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2067-2334 6.3e-83 273.1 In-house 5-276 (281) alignment 
Range on Protein: 2067-2334
Range on HMM: 5-276/281.0
YVKEKTANGEMCFKLDYERLPD-GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMV
 .|....| .  |. .|| | . |.  | . ....||| ||||.||. ||..|| .  . .. . |||||.||.|| ..|.|||||||. ... .||.||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WQERVPVIVMLTKLVENKKRKCDPYWPEDI--ETYGDFTLTVVAERNYLNYTERTLTIrKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE
|...| .|||.|. .|. | ||  |||.|    .|||.|.. .||..  .| ||.... .. . |.|.|....||.||| | | ... |||| ..|....
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

ARPS-GPTIVHCSAGVGRTGTYFTIDSMMDMSARE-QQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
 . .  | ..|||||||||||| ..| ...  ..| ....| . |  .| .|  ||||  || |.| |.|. |
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0042113 (Phosphotyrosine protein) phosphatases II 2095-2332 9.7e-83 272.6 In-house 2-241 (245) alignment 
Range on Protein: 2095-2332
Range on HMM: 2-241/245.0
EVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP-E
.|| ..||..|||| .|.||||.||.|  |.  .. ||||||.|.||  .. .|||||||. || |||||.|.... .|||||...|... ||..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA-RPSGPTIVHCSAGVGRTGTYFTIDSMMD
.. |||||| |.. | .. .|| |||.. .  |.|.| |.|.||..|||.| | .   ||.|.  |... |  ..||..||||||||||||. ... |..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.  .|. ... . |...| .| ..||||.||.|.||||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 2069-2331 3.6e-82 270.8 In-house 18-294 (306) alignment 
Range on Protein: 2069-2331
Range on HMM: 18-294/306.0
KEKTANGEMCFKLDYERLP---DGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDtDPDAPHEDYINASFVSGYLK--PKAYIATQGPLSTTVFDFWR
||..  .   |. ..|.|      .... . ....|| .|||| ||.|.||.||||  .|. | .|||||..... .|   |.|||||| |.||| ||||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MVWQERVPVIVMLTKLVENKKRKCDPYWPEDI--ETYGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVK
|||||   ||||.|| ||  | || .|||.    |.||. ..| |.|..  .|. |.|.. |   . |||.| ..|..|||| | | .   .|.|...|.
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

----EFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAR---EQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
    |.|.. .||..||||||.|||||.  || ....  .   . .|.. ..|  .|. |  .||| .|| |.|.|. 
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPN12_pd Subfamily PTPN12 2085-2333 4.4e-81 267.0 In-house 23-276 (290) alignment 
Range on Protein: 2085-2333
Range on HMM: 23-276/290.0
RLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKK
.. . ..|. |.....||| |||| .|.|||.||| | .. . ...|||||.|. |  ....|||.||||..|. |||||.|. .| ..||. ..||..|
kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

RKCDPYWPEDIE---TYGDFTLTVVAERNYL-NYTERTLTIRKAwdPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGR
 ||. ||||  |   ..|.|..|. .|..   ... |||....    |.|.|. ||||.||| | | ||..|||.|..|.|.. . . | .|||||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

TGTYFTIDSM---MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
|||  .|| .   .     .....| | | ..|..|. .||| |||...|.|..| 
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Ptp69D_pd Subfamily Ptp69D 2058-2352 1.4e-80 265.7 In-house 3-304 (307) alignment 
Range on Protein: 2058-2352
Range on HMM: 3-304/307.0
AVKIVELSGYVKEKTANGEMCFKLDYERLPDG-QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
|..|..|.  .| .  . .. .. .||.|.      . .|. ..||  |||| .|...|. ||.| . .   . |||||||. || . | .|| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP-EDIETYGDFTLTVVAERNYLNYTERTLTIRKAW-----DPEERRVQHFHYTSWPDMGLPLSAT
|..|||||...  | .||||..| | ...||. ||| ||.  |||   ..| |..  .|..|.| . |        ...|.|  .|||.|.|.  | .|.
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

PLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYF
 ||..|..|.| .    .| .|||||||||.|.. ..||...    |..... ..|  .| .|  .||  |||||.| |||.    | | .  ... . .
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

TR
 |
er
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2077-2350 3e-80 264.4 In-house 19-293 (315) alignment 
Range on Protein: 2077-2350
Range on HMM: 19-293/315.0
MCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVML
  |  ..  ||| ..|   ||  ..| .|||| ||.|.|..||.|.   | |..||||||.. .. . |||||.|||| ..| ||||||.||.|  |||.
alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TKLVENKKRKCDPYWPE---DIETYGDFTLTVVAERNYLNYTERTLTIRKAwdPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVH
||. |. | ||  |||.   |   .| . ....      . . | |..||.   | |.|  |..| ||| | .  .. ||..| .||  . .   . .||
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

CSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYF
|||||||||   .||....  .|.. ..|..||  .|.||...||| |.| |||.|.|| ||   | ..   .....
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl
subfamily_PTPN9_pd Subfamily PTPN9 2060-2333 3.3e-79 261.0 In-house 2-289 (297) alignment 
Range on Protein: 2060-2333
Range on HMM: 2-289/297.0
KIVELSGYVKEKTANGEMCfklDYERLPDG-QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTV
.| ||  |||||  .| .    .|. . .     | ...  . |..|||| ... ||..|| | . .. .. |||||.|| || ..||.|||||||  ||
eieelvayvkekgkrGlsk...eyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktv

FDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP---EDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEF
 |||||||...| |||| |..||....||  |||   |. . .||.....|  ... .|..|.|.|... . |.|.| || ..|||| | | ||. ||..
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

ITKVKEFEA------------RPSGPT-IVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
. ||.|  |            .||||  .||||||.|||||. |.|  ..   ......| . | ..||.|  ..||||||.| | |.|| 
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0037934 (Phosphotyrosine protein) phosphatases II 2094-2332 1.4e-77 255.8 In-house 2-240 (243) alignment 
Range on Protein: 2094-2332
Range on HMM: 2-240/243.0
WEVATRQENVSKNRYINIIPYDHSRVILdtdpdaPHEDYINASFVSGYlkPKaYIATQGPLSTTVFD----FWRMVWQERVPVIVMLTKLVENKKRKCDP
. .| ..||.||||| .|.|||||||.|      . .|||||... ..  |. .|||||||. ||.|    ||||.|.... ||||||.|||... ||..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPEDIeTYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEF--------EARPSGPTIVHCSAGVGR
|||... |||||| |.. |... .|| |||...    |...| |.|.||..|||.| | | ..||.|. .|.||         . ..||..|||||||||
ywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTYFTIDSMMDMSareqQINVLDFVYRMRTKRVK-MVQTPEQYVFIYEALLE
|||. ... |...     ...... | ..|..|   .||||.||.|.||||||
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2338-2633 1.7e-76 252.3 In-house 2-294 (298) alignment 
Range on Protein: 2338-2633
Range on HMM: 2-294/298.0
YTSVPTKTIVQYFTRLEQTNLHTKRTFLEEHLSALDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMY
 | . .... . ...|.. . ..| | ...    |...|    . ........||..||||.| |.||. |  | .  .. ...|.||.||.....|. .
nteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnaf

IATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVateSSRVIRQYSFVGWKER
|||| ||..||||||||. ......||||....  |. ....|||   ..  | . ... ..|. .|.|.|.. .|....    ..| .|| .|. | ..
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdk

QkYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
.  |.   |.| ||. |.| |.. || |..|.| .||.||| |.|| | . ..| |  .|||..|| |||    .| .|||| .|...| |.|.| .
g.vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_PTPRD_pd Subfamily PTPRD 2383-2633 5.1e-76 251.5 In-house 39-285 (564) alignment 
Range on Protein: 2383-2633
Range on HMM: 39-285/564.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWP
...| . ..| .|||| . .. |. |  | .   . ...|.||.|.||...|  ||||| ||..|.||||||....||..||||.... .  . |..|||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

AGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQrDLGNGPITVHCMDGVTRSGLFCA
. ... .| .......||.  |..|||| |....   ...|| .||. |. | ..   |.| .||| |.. |.| .   ..|||.|||  || |.| |..
ekgtetygeltVtleeeeeladyeirtfklkkkk...ssesreVrqFhFtsWPdhg.vpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfiv

IMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
| . . ..|.|...|..  ||.|||    || .|||| .||... |.||. .
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2056-2367 2.3e-74 245.4 In-house 2-321 (325) alignment 
Range on Protein: 2056-2367
Range on HMM: 2-321/325.0
PPAVKIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLS
| .. .|.|  .|..| |. .  |  ... ||  .  . .||.. ||..|||. |....|.|||.| |  |.|. ||||||..  . | . ..|.| ||.
pgsiavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlt

TTVFDFWRMV--WQerVPVIVMLTKLvENKKRKCDPYWPED---IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSAT
.|. |.||.|  |.   .|.|.| .| ...| .|  |||..     |.| . . ...  .. .|  | | .... . | | |. |.. ||.||| .   .
atindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpa

PLLEFITKVKEF------EARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTK
 |. ..  ||.       ... |.| .|||||||||||.. .. |...    | ......|| ..| .| .||.| .||..||||| | ...| | ||  
tlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs

TIVQYFTRLEQTNLHTKRTFLEE
..   .. |.. |  |..  .|.
sfeaklsslqernpltqklniek
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2078-2343 1.3e-73 242.8 In-house 27-293 (297) alignment 
Range on Protein: 2078-2343
Range on HMM: 27-293/297.0
CFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKpkAYIATQGPLSTTVFDFWRMVWQERVPVIVMLT
 |. ..  ||  ....  || .. | .|.|| ||.||| |||.|    | |  ||.||||| |. .   .|.|| |  .|| |||.||..|.| .||||.
vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln

KLVENKKrKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPL--SATPLLEFITKVKE-FEARPSGPTIVH
.. |..| ||  ||... . |.|| .... .  .   . .|.|...|     .| |. .....|||   .   ||. ||..|. |.. |. . .|| .||
ddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPT
|.||||||| . ||||..    ||........| ..| .|...||| ||| |.|.|.|| ||.  | ...
claGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2101-2332 4.2e-73 240.8 In-house 27-266 (274) alignment 
Range on Protein: 2101-2332
Range on HMM: 27-266/274.0
ENVSKNRYINIIPYDHSRVIL-DTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIET-
 . .|||| .|.| ..|||.|   .....  .|||| .. ||  . |||.||||||..||.|||||..||.|.|||||||| |....||  |.|..... 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

----YGDFTLTVVAERNYLNYTERTLTIRKAWDpeERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE---ARPSGPTIVHCSAGVGRTGTYFTIDSM
    |||. ..|.   .  .|. |.|..... .  ||.|.|. ||.|||.  | .|..||.....|.| .   . . .|..||||||.|||| . .|.  
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.    .|. ..||  |  .| .|  |||| ||| .|..|| .
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2069-2354 4.8e-72 238.0 In-house 26-311 (319) alignment 
Range on Protein: 2069-2354
Range on HMM: 26-311/319.0
KEKTANGEMCFKLDYERLPDGQ--MYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVW
|..  .    .. .. |...      . . |  ..|  |||.|||...|...| |.        ||||||||.|| ... |||.||||  |. |||||.|
ksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiw

QERVPVIVMLTklvenkKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA
. ..  ||.||      | ||  ||| .| .... | . | .  .  .|. | . . . .   . |... ||.  |||.| | ....|. .. ||. .. 
eyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

RPSGP--TIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
.  ..   .|||||||||||.| ..| ..|.  .|.|..| .||  .| .| ..||   || ||| ||||  | |.. |    .  |. .| 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
0051299 (Phosphotyrosine protein) phosphatases II 2339-2629 6.3e-72 237.8 In-house 3-286 (288) alignment 
Range on Protein: 2339-2629
Range on HMM: 3-286/288.0
TSVPTKTIVQYFTRLEqtnLHTKRTFLEEHLSALDAMSIfysdVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYI
|..... ..... .|    .. . ..|||.   |.        ... |..  ||..||||.| .|.|. | .| .  ... ..|.|| ..||.|.   .|
teisveellklvlkll...angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTV-ATESSRVIRQYSFVGWKeR
||| ||..||||||||....|..|||||...  .. ..| |||| |.   .|....    || ..|...||. ..|....  .. || .... . .|   
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.d

QKYPKSLASLLCLLDLVEAGQRdLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
. .| |. .|| .| ||   ..  |.||. |||..|| |.| |.|.   .  |. || .||..|||.||..   ||...|||....... |||
hgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 2092-2332 2.6e-71 234.8 In-house 31-273 (280) alignment 
Range on Protein: 2092-2332
Range on HMM: 31-273/280.0
YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVSGYLKP----KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKC
 . ..| . ||.||||| .|.|||. ||.|.  .     |||||..|.  .      . ||||||||..|. |||.|||.... .||||| |||. . ||
laisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DPYWPEDIE--TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYF
  ||||  .  .||.|....  |..  .|  | |.....   |||.. .. |..||| |.| ... .|||...|..  .  . |..||||||.|||| . 
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

TIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
...  . .  .......|| | .|| .|  .|||..|| |. ||.|.
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0050432 (Phosphotyrosine protein) phosphatases II 2360-2635 3.7e-71 235.3 In-house 39-305 (308) alignment 
Range on Protein: 2360-2635
Range on HMM: 39-305/308.0
TKRTFLEEHLSALDAMSIfysDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcsEGQTNYVNATFLDGF--NRRDMYIATQMPLQHTVEDFWRMIYD
. ...|||   .| .. .   . .. ...  ||..||||.| .|.|. | .|     .. ..|.|| . ||.  ...  .|||| ||..||||||||...
ldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

YNSNVIVMLNEINRND-QTCSQYWPAG---DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLV
.|..|||||...  |. ..| ||||     .   .|.|.. .  || ..|...||. |.|..   .. ||..... . .|.  .. | |...|| .|.||
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg...dgesrtvthfhytnWp.dhgvPpspeilldflelv

EAGQrdlGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIY
.  .   ..||| |||..|| |.| |.|.   .  |. ||..|||.||||||..   ||...||||...... ||| . ...
rksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2097-2354 1e-70 233.5 In-house 20-275 (284) alignment 
Range on Protein: 2097-2354
Range on HMM: 20-275/284.0
ATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTklvenkKRKCDPYWPEDI-
|  ..|  |||...|...|...| |.        |||||||..|| ... ||||||||  |. |||||.|. ..  ||.||      | ||  ||| .| 
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

ETYGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSG--PTIVHCSAGVGRTGTYFTIDSMMD
.... | . | .  .  .|. | . . . .   . |... ||.  |||.| | ....|. .. ||. .. .  .  . .|||||||||||.| ..| ..|
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
.  .|.|..| .||  .| .| ..||   || ||| ||||  | |.. |    .  |. .| 
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2387-2636 5.6e-70 230.4 In-house 4-249 (250) alignment 
Range on Protein: 2387-2636
Range on HMM: 4-249/250.0
GKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDEA
.|  .|..|||| | |.||. |  | .  .. ...|.||.||.|.. |...|||| |||.|.||||||.....|..||||.... ...|..||||.    
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

LIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTI
  |   ...  .|  .|...|.. ||...    ...|..||..|| | ..   |.   . | ||. |.| |.  ||.|. |.|  ||.||| |.|| . .
kyGdvtvsllskeefadytkrklklskak...kaderivrqlhfvvWPdkg.vPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYE
 .|| |  .|||. .|.|||   ..| |.||| ... .. ..| | | |.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2059-2334 6.6e-69 227.0 In-house 2-283 (290) alignment 
Range on Protein: 2059-2334
Range on HMM: 2-283/290.0
VKIVELSGYVKEKTANGEMCFKLDYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAP--HEDYINASFVSGYLKPKAYIATQGPLS
... ... .| ...|.|.  |. ....|  |.  .| .|.. ..|  .||. ||..||  |..|   .. .   ..||||... || . |.|||||||.|
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE-DIETYGDFTLTVVAERNYLNYTERTLTIRKAWD-PEERRVQHFHYTSWPDMG-LPLSATPL
 |. |||...|||.|..|||||. .|..| ||  |||. | ..|| |..... |... .|.||.| ...     ... |.... |.|.. | ..  .| |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
| .   .|    |  .. .||||..|||.... ...  ..    |..|.|.. ....|... ..||| .|| .|.. .|. |
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2095-2332 9.3e-69 226.2 In-house 1-239 (239) alignment 
Range on Protein: 2095-2332
Range on HMM: 1-239/239.0
EVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE
| | .. | .|||| ||. ||||||.|.   . || ||||||..  |   ||||||||| ....  |||||.||||  |||||| |.| .|.||  |||.
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDM
    | .. .|.     . .|  ||. . .  . ||| | ..|.| ||| |.|  || .| .  |. .     . | ..||||||||||... ||.|.  
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
. ... ......|  .|  | .|||| ||||||. |.||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2098-2332 1.1e-68 225.9 In-house 3-238 (239) alignment 
Range on Protein: 2098-2332
Range on HMM: 3-238/239.0
TRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE
 .. | .|||| ||. ||||||.|.   . || ||||||..  |   ||||||||| ....  |||||.||||  |||||| |.| .|.||  |||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAR
 | .. .|.     . .|  ||. . .  . ||| | ..|.| ||| |.|  || .| .  |. .     . | ..||||||||||... ||.|.  . .
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.. ......|  .|  | .|||| ||||||. |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN13_pd Subfamily PTPN13 2094-2334 1.4e-68 226.2 In-house 29-269 (273) alignment 
Range on Protein: 2094-2334
Range on HMM: 29-269/273.0
WEVATRQENVSKNRYINIIPYDHSRVILDTDPDaphedYINASFVSGYLKPK--AYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYW
 ||. ..|| .|||| |..|||..||.|. .       |||||..   .  .   |||.|||| .|| |||.|||. .. ||.|.|. .|..| ||. ||
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PED----IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArPSGPTIVHCSAGVGRTGTYFTI
||     .  .. ......   .. ... |.|....    | |.|.|.....||| | | ||..||.|...|....   .|| .||||||.||.||. ||
PesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtliti

DSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
| .... .|.....| . | ..| .|  .||| .||.|.|.|.|| |
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPRK_pd Subfamily PTPRK 2384-2627 4.2e-68 224.5 In-house 35-275 (314) alignment 
Range on Protein: 2384-2627
Range on HMM: 35-275/314.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPA
 .| |  ||..|||. | .. |. |. |.|   . ...|.||...|...|   .|.|| |||.||.||||..||.|.  ||||.|.  .    |..||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

GDEAlIGPFVIDVSAEEREGDVIIRTFLLSNTNTvATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDlGNGPITVHCMDGVTRSGLFCAI
  |   |.. . .   | . ....|.| .....  . |  |..||. |.|| .  . |.|  .|| |.  |.. | . ..|.| |||. |  |.| |.||
dtev.ygdikvelvetellaelvvrifrveklar.gqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiai

MSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
 . .  .. || .|||.|||.||.    ||  |||| .|.||. |
divldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2385-2636 9.8e-68 223.5 In-house 40-287 (318) alignment 
Range on Protein: 2385-2636
Range on HMM: 40-287/318.0
QAgKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAG
..  .. |..|||| . .. |. |  | .  .| ...|.|| ..||..|.  |||.| || .|.||||||... || ||||| .  .|  . . .|||  
ks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk

DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIM
.   .|  |.... | . .| ..|.| ...|.   .|.||..||| .  | ..   |.| |||| |.  |.. |.. |.|||.|||  || | | |.|. 
gsrsygklvvelkeevelsdyvlrefkvtrte...eeesrqvrqyhytsWpde.gvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd

STIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYE
. . ..| |. .|||. ||.||.    ||  |.|| .|.||. |.||| . . 
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2063-2340 1.1e-67 223.0 In-house 6-284 (287) alignment 
Range on Protein: 2063-2340
Range on HMM: 6-284/287.0
ELSGYVKEKTANGEMCFKLDYERLPD-GQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILDtdpdAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFD
... .|.. .|.|.  ||  .  | . .|      ..  ..|  |||. .|...|  ||.|       |.|||||.|. || . ||.|....|.. |. .
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarn

FWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMG-LPLSATPLLEFIT
||.......|..||||... ||....|  ||||.   ..|....... |  . .|.||.| ...   . ....|. ...|.|.. | ..  .| || .  
fWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

KVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTS
..|.   |  .. .||||..|||....  ..  .. . .|  |.|.. . ..| .. ..||| ||| ||....|| | .. | 
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0046845 (Phosphotyrosine protein) phosphatases II 2382-2634 1.6e-67 223.2 In-house 18-279 (284) alignment 
Range on Protein: 2382-2634
Range on HMM: 18-279/284.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSE-GQTNYVNATFLDGF-----NRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-Q
.|. ...  ||..||||.| .|.|. | .| .  .. . ..|.|| ..||.     ...  .||||.||..||||||||....|..|||||.|.  |. .
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

TCSQYWPAGD-EALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRD-LGNGPITVHCMDG
 |.||||  .    .|.| . .  || ..|...||. |.|...  |. || .... . .|   .. | |...|| .|.||.  ...  |.||| |||..|
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgy..tgesrtvthfhytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaG

VTRSGLFCAIMSTIGKLKSEG---NIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEI
| |.| |.|..  .  |. ||   ..||..|||.||..   || ..|||....... ||| .  .
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0040438 (Phosphotyrosine protein) phosphatases II 2361-2634 6e-67 221.5 In-house 17-281 (317) alignment 
Range on Protein: 2361-2634
Range on HMM: 17-281/317.0
KRTFLEEHLSALDAmsifY-SdvSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYN
.. .|||.   |.       .  ... ..  ||..|||||| .|.|  | .|    .   ..|.|| . ||.|... .|||| ||..||||||||.....
ftalleefedllsl....kld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

SNVIVMLNEINRN-DQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQR
..|||||.|   . ...| |||| |..  .|.|.. .  || ......||. ....    .. || .... . ||   .. |.|. .|| .|..|.. ..
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWp.dhgvppspdllldfleavreale

dLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEI
  ..||. |||..|| |.| |.|.   .  |. ||..||..|||.||.. . .|...||| ...|...|||   . 
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0047943 (Phosphotyrosine protein) phosphatases II 2359-2629 1.4e-66 220.1 In-house 9-272 (273) alignment 
Range on Protein: 2359-2629
Range on HMM: 9-272/273.0
HTKRTFLEEHLSALDAMSifysDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDY
  ....|||.   |.       ........  ||..||||.| .|.|. | .|    ..| ..|.|| ..||.|.   .||||.||..||||||||....
lgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NSNVIVMLNEINRNDQ-TCSQYWPAGD---EALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVE
|..|||||.|.  ... .| ||||      .   |.| . .  || ..|...||. |.|..   |. ||..... . ||   .. | ||.||| ...||.
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...tgesrtvthfhytgwp.dhgvppslesllefielvr

AGQRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
  .. | .|||. |||..|| |.| |.|.   .  |. ||..||. |||.||..   ||...|||....... |||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2083-2332 2.4e-66 218.5 In-house 1-262 (270) alignment 
Range on Protein: 2083-2332
Range on HMM: 1-262/270.0
YERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVE
...|. ... . .. .   .   ||| .|.|  ..||.|..  . ..  |||| .| |.  ..|.|||..||| ||...||||.|.|.|. |||.|.|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

NKKRKCDPYWPEDIET-----YGDFTLTVVAERNYLNYTERTLTIRkaWDPEERRVQHFHYTSWPDMGLPLSAT------PLLEFITKVKEFEARP--SG
. ..||. |||.. ..     .|. . ....|..   |  . |...   . ||||. ||.|..||| | | ..        ||. . .|...| .   ..
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
|..||||||||||||  ..| .. .  ......||  . ..| .|...||.|||| |.|.|..|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_CG7180_pd Subfamily CG7180 2076-2338 2.9e-66 218.1 In-house 16-294 (296) alignment 
Range on Protein: 2076-2338
Range on HMM: 16-294/296.0
EMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVM
.. .|| ..  |  .. .   . |.||  |||.....|||. ||.|..     ..|||||..| ..||.|.|| |..|   || .|||.|..| .  .|.
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LTKLVENKKrKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKA----------WDPEERRVQHFHYTSWPD-MGLPLSATPLLEFITKVKEFE
|||  . .| ..  |||..  | ||.. . .| |..| | . ||. . |            . |.| |..|..| |.    .|||.. |.|.. .|. . 
Ltktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

ARP-----SGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
 .       ||..|..| |..|.| |..||  ...  .|....| ..| ..| .| ..|.. |.| .||. ||| .||. 
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2382-2633 7e-66 217.5 In-house 38-287 (319) alignment 
Range on Protein: 2382-2633
Range on HMM: 38-287/319.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYW
....  .  ||..||||.. .. |. |  |..     ...|.||.|.||...|. .|||| ||..|.||||||.....| ..|||.... .    ...||
dtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

PAGDEALIGPFVIDVSAEEREGDVIIRTFLLsNTNTVATESsRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFC
|  .    | .....  ||.  |.||| . | |...   |. | . .. .  | .  . |... ||| ||  ..  ..   .|||.||| .|| | | |.
peenfeeyGrlivtleeeeeledyiirklkl.nkkssevet.RevkhfqyteWpdh.dvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi

AIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
..  .. ..| || .|||. |..||     ||  .||| .|.....|.. . .
vldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2371-2635 1e-65 216.5 In-house 25-289 (290) alignment 
Range on Protein: 2371-2635
Range on HMM: 25-289/290.0
ALDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLM--TGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE
   ..  . |. ... | .|.|...||. . .. | .|  |   .|  . . .|.||....|.. .  ||||| |...|. |||..|.. .. .|||| .
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltn

INRNDQ-TCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVatESSRVIRQYSFVGWKERQKYPKSLASLLCLlDLVEAGQRDLGNGPITV
|. ... .| ||||. | . .|.| | .. ||   . |.|.. . |.|.   .... . || .  |..  | ..  ..|| .   ..  ||  ||..| |
iieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvi.eemyktqrkrgntsivv

HCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIY
|| |.|.||..|||.. || | |.|| ||||. .|..| .   .| ...|| .|...| .|| | | |
HCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2377-2638 1e-65 216.9 In-house 31-295 (305) alignment 
Range on Protein: 2377-2638
Range on HMM: 31-295/305.0
IFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQT
.   . |.. ||...|..|||. ....||. |  | .  |.....|.||...||..|.. ||..| ||..||.||||.|...  ..|||| ..  . .. 
lyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdk

CSQYWPAGDEA--LIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGV
| ||||        .|.|.. .. |.   | |.| . .|. ..   . ||.. || .  | . .  |.. .||| |.. |.  |.   . |..||| .||
CrqYWpesktekkefgefsvelksektasdyieRklkisiede..dkesrtvlqyqltdWPd.hGvpqfatsllslikrvqkdqkkdkgvpllVhCsagv

TRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE---IYENF
 |.| |.|.   . .|| |. .|||. .|.||.    || . .|| ..||.. |.. . .   | .|.
gRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
0036941 (Phosphotyrosine protein) phosphatases II 2379-2633 1.3e-65 216.9 In-house 26-281 (297) alignment 
Range on Protein: 2379-2633
Range on HMM: 26-281/297.0
YSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCS
. . |. .... || .||||.| .|.|. | .|    ... ..|.|| ..||...   .|||| ||..||||||||....|..|||||.|    . ..| 
lllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPAG--DEALIGPFVIDVSAEER--EGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDL-GNGPITVHCMDG
||||    ..   |.|.. .  .|   ..|...||. ...|    .. ||..... . || .  . | | |||| ...||.  .. | ..||. |||..|
qywpleegesltygdftvtllsvevvllddytlrtlevtdt...gngesrtvthfhytgwpdh.gvpespaslldfielvrkvlkllpsggpvlVHCsaG

VTRSGLFCAIMSTIGKLK---SEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
| ||| |.|.   .  |.    ||..|.. ||||||..   .|...|||....... |.| . .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0039614 (Phosphotyrosine protein) phosphatases II 2355-2629 1.7e-65 216.8 In-house 24-289 (297) alignment 
Range on Protein: 2355-2629
Range on HMM: 24-289/297.0
QTNLHTKRTFLEEHLSALDAMSIfysDvsMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSE-GQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFW
. .  ...|.|...   |  . .   |  .  ... || .||||.| .|.|  | .| .  .    ..|.|| ..||...  . .|||| ||..||||||
llekansktllllefeellslkp...d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDEaLIGPFVIDVSAEEREGDVIIRTFLLSNtntvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDL
||.......|||||.. . ....| ||||   .   |.|.. .  .| ......||. ..|     .. || .... ..||    . | ||..|| .|.|
rmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.....ngesrtvthfqytgwp.dhgvppslellleflel

VEAGQRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|.  .. | ..||. |||..|| |.| |.|.   .  |..||..||..|||.||.. . .|....|| ...|...|.|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPN1_pd Subfamily PTPN1 2090-2335 2.5e-65 215.1 In-house 20-272 (290) alignment 
Range on Protein: 2090-2335
Range on HMM: 20-272/290.0
QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDP
. .. ..| ..|| ..||| .. ||||||..|. .      ||||||.|      . || |||||. ||  ||.|||...   .||| |.||... ||  
sdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPEDIE----TYG--DFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE--ARPSGPTIVHCSAGVGRT
|||.. |    ..    .......| .. .|| |.| . .    | | . |||||.|||.|.| | . .|.|. ||.|    ..  ||...|||||.||.
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GTYFTIDSMM-DMSAREQ--QINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
||.  .|...  . ....   ... . .  .|  |. ..||..|  | | |.||   
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2362-2626 5.1e-65 214.4 In-house 20-276 (288) alignment 
Range on Protein: 2362-2626
Range on HMM: 20-276/288.0
RTFLEEHLSALDAMSifySDVSMQAGKSSENHHKNRYPDNIPLDkYRPYLMTGCSE-GQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNS
|| ..|.  .| |.    .. | .||. ..|..||||.. .|.| ...  ...  |  ...|.||...|| ...  ||||| ||..||.|||...|....
rtgfseeynsLaale...ktksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

NVIVMLNEI-NRNDQTCSQYWPAGDE-ALIGPFVIDVSAEEREGDVIIRTFLLSntntvATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQR
. ||||.|. ......| .|||..|.  . | . . .  .. ..|.. |..||       ... . | || . .| . .  |.| | || ||. |.  . 
stivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhg.vPeskapllellrqvkvanq

DLgNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
.   |||.|||..|| |.| | |.   | ....|  |||. .|.||||    .|  ..|| .|..|. 
ad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2077-2354 1.3e-64 213.0 In-house 20-256 (392) alignment 
Range on Protein: 2077-2354
Range on HMM: 20-256/392.0
MCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVML
  |  ..  ||. ..|   || .. |. |||| ||.||| .||.|.   | |..||.|||.. ..   |||||.||| .... ||||||.||.|  |.|.
alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TKLVENKkrkcdpywpedietygdftltvvaernylnytertltirkaWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSA
||| |                                              . | |  ||.| ||| ..|  .. ||.|| .||    . . | |.||||
tklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
||||||   .|||..  . . . ..|..||  .| ||  |||| ||| ||| |.|| ||   | .|   .... . |.
gvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
subfamily_Ptp69D_pd Subfamily Ptp69D 2352-2630 1.3e-63 210.0 In-house 12-287 (307) alignment 
Range on Protein: 2352-2630
Range on HMM: 12-287/307.0
RLEQTNLHTKRTFLEEHlSALDAMsifYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDF
 |.. . .|.  ...|.   | |     .| | ....  ||  ||||.| .. ||.|  | .   . ...|.|| |. |.. .  .|| | |.. |..||
alksrkrdtdfglakey.ekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDf

WRMIYDYNSNVIVMLNEIN-RNDQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVA--TESSRVIRQYSFVGWKeRQKYPKSLASLLC
|||| . ....|||| ...  |.. |..|||  ||   |  ....  ||. .| |||.. .|...  .   | || . ||.. |||   | |..  .|| 
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllk

LLDLVEAGQRDLgNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|.. |.  ..   ..||.|||  || |||.| |. | . .|| | ..|.|. ||.||.    .| | ||| ...  . .|  
lieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2101-2332 1.6e-63 209.1 In-house 2-237 (237) alignment 
Range on Protein: 2101-2332
Range on HMM: 2-237/237.0
ENVSKNRYINIIPYDHSRVILDTDPDAphEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE--DIET
||  |||| ||. ||||||.|     .   |||||... |.   || |||.|||| ..  |||.|||||.  |||||| |.|... ||  |||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDFTLTVVAERNYLNYTERTLTIRKAWDPEERR-VQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR--PSGPTIVHCSAGVGRTGTYFTIDSMMDMS
|| .|...  . .. .|| |.|.. | .  .| | .. ...||||| |.|  .. || |  .. .       ||| |.|||||||||| .. ||.|.  .
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
  .. ... ..|| .   |  ..|| .|||||....||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
DSPc_SM00195 2383-2629 1.7e-63 209.8 In-house 17-262 (263) alignment 
Range on Protein: 2383-2629
Range on HMM: 17-262/263.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP
... .. ..|..|||| . .| |. |  | .  .. ...|.|| ...| |..  |||||.||..||||||||... ....||||.| .  . ..|..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

AG--DEALIGPFVIDVSAEEREG-DVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLgNGPITVHCMDGVTRSGL
    ..  .| . . .  .| .  ..|.||. |.....   | .| ..|| . .|... ..|.|  |.| ||  |.  ..   .||| ||| .|| |.| 
eesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgt

FCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|..| . . ||..| ..|.|. ||.|||   .|| ..||||.|.... ||.
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2383-2629 1.7e-63 209.8 In-house 17-262 (263) alignment 
Range on Protein: 2383-2629
Range on HMM: 17-262/263.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP
... .. ..|..|||| . .| |. |  | .  .. ...|.|| ...| |..  |||||.||..||||||||... ....||||.| .  . ..|..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

AG--DEALIGPFVIDVSAEEREG-DVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLgNGPITVHCMDGVTRSGL
    ..  .| . . .  .| .  ..|.||. |.....   | .| ..|| . .|... ..|.|  |.| ||  |.  ..   .||| ||| .|| |.| 
eesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgt

FCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|..| . . ||..| ..|.|. ||.|||   .|| ..||||.|.... ||.
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 2348-2629 1.9e-63 209.9 In-house 6-277 (278) alignment 
Range on Protein: 2348-2629
Range on HMM: 6-277/278.0
QYFTRLEQTNLHTKRTFLEEHLSALDAMSifysdVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHT
..  .|.. .|  |...|.|. . |.         ..  ... ||..||||.| .|.|  | .|    ..  ..|.|| ..||.|. . .|||| ||..|
dllkallelllnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPaGDEALIGPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKeRQKYPKSLASL
|||||||........||||.|   .. ..| |||| |.   .|.|.. .  || ..|...||. ..|     .  || ...| ..||   .. | ||..|
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwp.dhgvpeslsll

LCLLDLVEAGQRdLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
| .|  |   ..   |||. |||..|| |.|.|.|.   .  |..||..|...|||.||.. . .|....|| .......|||
ldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 2382-2629 6.6e-63 207.6 In-house 48-295 (330) alignment 
Range on Protein: 2382-2629
Range on HMM: 48-295/330.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN-RNDQTCSQYW
 .... .  ||..|||... .| |  | .| .   . ...|.||.|.||....| .||.| |...|||||||||....|  |||| |.. |... | |||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTV-ATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNgPITVHCMDGVTRSGLF
|       |   . |  |.   |. .| ||. . .     ..||..||. | .| .    |     .| ||  |.. ..  .. ||.|||  || |.| |
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtf

CAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
... . . ..|.|. .|||..||.||.   .|| ..||| .|. |..|| 
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN23_pd Subfamily PTPN23 2094-2332 1.5e-62 206.1 In-house 35-278 (288) alignment 
Range on Protein: 2094-2332
Range on HMM: 35-278/288.0
WEVATRQENVSKNRYINIIPYDHSRVILDtdpdAPHEDYINASFVSGYLK-PKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
  .|  . ...|||. .|.||||.|| |.      ..|||||||| .       .||||.|| .|. |||.||......|||||..  | .| |.| |||
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

EDIE---TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKE----FEARPSGPTIVHCSAGVGRTGTYF
|| .   ..||...|.  .|.  .. ||.|...     . . |.| ..||||..|.| |   ||.|. .|..     . .   | .|||||||||||.. 
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

TIDS-MMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
 . . . ......  ..... | |.|..|  |||. ||. | ||| ||
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2383-2638 1.6e-62 206.1 In-house 38-287 (287) alignment 
Range on Protein: 2383-2638
Range on HMM: 38-287/287.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWP
..  . .|.|..|||. . .. |.||  |     . . .|.||.|.||.. .  .|... |. .|. .||..| | | ..|||| . . ||.  | ||||
evthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp

AGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEaGQRDLGNGPITVHCMDGVTRSGLFCA
 ..  ..|.. | .  ||.. ..|.|.. . |.|   ... . ..|| .  |... | ..  ..|| . . .   ||  ||..| ||| |.| ||..|||
eeksvvlGeyniellneevnagyierklevknknk..agdkqqvkqyqitnWdstgkvtepqtillvieemyk.tqrkrgntsivvhCsdtvGrsamfca

IMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYENF
.  || | | || ||||  .|. |     .|   ||| .| |.| ||| | |.| .|
aattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0045450 (Phosphotyrosine protein) phosphatases II 2357-2629 2.9e-62 206.5 In-house 21-304 (307) alignment 
Range on Protein: 2357-2629
Range on HMM: 21-304/307.0
NLHTKRTFLEEHLSALDAMSIFYsDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSE-GQTNYVNATFL--------DGFNRRDMYIATQMPLQHT
.| . .| |...   |  . .|.   .. .... ||..||||.| .|.|  | .|..  .. . ..|.||..         ||... . .|||| ||..|
llldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEA-LIGPFVIDVSAEEREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWKeRQKYPKSLAS
|||||||.......|||||.|   ...  | ||||  .|   .|.|.. .  || ......||. ....    |. || .... . ||   .. |.|...
vedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwp.dhgvppsfee

LLCLLDLVEAGQRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGN---IDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|| ....|.. ...| ..||. |||..|| |.| |.|.   .  |..||    .|...|||.||.. . .|...||| .......|.|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2385-2632 3.3e-61 202.2 In-house 41-291 (325) alignment 
Range on Protein: 2385-2632
Range on HMM: 41-291/325.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAG-
..    ||  |||... ..||| |. | |   .....|.||..|  . ..|...|.|.|| .|..|.||...|... |.|.|||.. ... |..|||   
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkem

-DEALIGPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWK--ERQKYPKSLASLLCLLDLVEAGQRD--LGNGPITVHCMDGVTRSGL
 .    |.. . . . |   | . | . . .   |    .| ..|. . .|.    ||.| .|.|.| |.. |.   .    . .|| |||..|| |.| 
gksktfGglevklrtieeisdyvhrvldvkq...vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASC
| .. | . |.  | ..|.|  ||||||    || . .||  |.. . |.. | 
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
0040439 (Phosphotyrosine protein) phosphatases II 2387-2629 6.5e-61 201.4 In-house 6-246 (249) alignment 
Range on Protein: 2387-2629
Range on HMM: 6-246/249.0
GKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWPAGDE
..  ||..|||||| .|.|  |..|    .   ..|.|| ..||... . .|||| ||..||||||||.......|||||..  ..  ..| |||| |..
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

ALIGPFVIDVSAEEREGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRDL-GNGPITVHCMDGVTRSGLFCAIMS
  .| |.. .  .| ..|...||. |.|.    . .|| .... ...|   .. |.|...|| ....|.  ...|  .||. |||..|| |.|.|.|.  
leygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 .  |. |...|...|||.||.. . .|...||| .......|.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 2392-2625 1.4e-60 200.0 Pfam-A 1-233 (235) alignment 
Range on Protein: 2392-2625
Range on HMM: 1-233/235.0
NHHKNRYPDNIPLDKYRPYLmtGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP--AGDEALI
|..||||.| .| || |  |    |||...|.|| ...|...  ..||||.||..|.||||||.......|||||.. .  ....|.||||   ...   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPFVIDVS-AEE-REGDVIIRTFLLSNTNTVAteSSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQrDLGNGPITVHCMDGVTRSGLFCAIMSTI
| . . .   |.  | ....|.. |.....     .| ..|. . .|.  .. |.|  ||| |.. ||  . .  .||..|||..|| |.| |.|..  .
gdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 .|..|...||...||.|||.   || |.||| ......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 2392-2625 1.4e-60 200.0 In-house 1-233 (235) alignment 
Range on Protein: 2392-2625
Range on HMM: 1-233/235.0
NHHKNRYPDNIPLDKYRPYLmtGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP--AGDEALI
|..||||.| .| || |  |    |||...|.|| ...|...  ..||||.||..|.||||||.......|||||.. .  ....|.||||   ...   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPFVIDVS-AEE-REGDVIIRTFLLSNTNTVAteSSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQrDLGNGPITVHCMDGVTRSGLFCAIMSTI
| . . .   |.  | ....|.. |.....     .| ..|. . .|.  .. |.|  ||| |.. ||  . .  .||..|||..|| |.| |.|..  .
gdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 .|..|...||...||.|||.   || |.||| ......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRN_pd Subfamily PTPRN 2092-2332 5.2e-60 197.7 In-house 46-290 (297) alignment 
Range on Protein: 2092-2332
Range on HMM: 46-290/297.0
YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGY-LKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
 | ||| ...||.|||. ...||||||| |... .| ..||||||..     .  |||||||||..|| |||.|||.. | |||.||.| |.  ..|. |
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPED-IETYGDFTLTVVAERNYL-NYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKE-FEARpSGPTIVHCSAGVGRTGTYFTI
||..  |.|. . . .|.|  .  .|  |.. ..     | | |  ||. |||..| | || .||||  ||   .  | | | .||||.|.||||.|  |
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr.scpivvhcsdGaGrtGvyili

DSMMD-MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
| ... .    ..|..   .  .| .| ..|.| .|. |.. |. |
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0042113 (Phosphotyrosine protein) phosphatases II 2388-2629 2.5e-59 196.0 In-house 5-243 (245) alignment 
Range on Protein: 2388-2629
Range on HMM: 5-243/245.0
KSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGDEA
.  ||..||||.| .|.|  | .|.   ..  ..|.|| . ||... . .|||| ||..||||||||........||||.|   .. ..| |||| |.. 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

LIGPFVIDVSAEEREGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTI
 .| |.. .  || ..|...||. ..|.    .  || ...| ...|   .. | .|..|| .|..|.  ... .|||. |||..|| |.|.|.|.   .
tygdftvtllseehlddytvrtlevtnl...gddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
  |..|.......|||.||.. . .|....|| .......|.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2097-2344 4.3e-59 195.1 In-house 43-289 (439) alignment 
Range on Protein: 2097-2344
Range on HMM: 43-289/439.0
ATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKrkcdpYWPEDIE
|... . .|||| .. ..||.||.|.  |  ||  |||| .. || ..| |||||||   |. ||||.|.....  |||||.|||  |     ||| | |
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae

TY-GDFTLTVVAERNYLNYTERTLTIRKAWD--PEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEF-EARPSGPTIVHCSAGVGRTGTYFTIDSMMD
.. || .. |  . .  ||. | . . .  |    || | .|||..|||  .|  |. .|.|.  ..   . .  || .||||||||||||  ..|  ..
vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTK
    |.....   |  .| .| .|||.  ||||||.|.|| .  | ..|   
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtid
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2384-2629 3e-58 192.2 In-house 41-279 (315) alignment 
Range on Protein: 2384-2629
Range on HMM: 41-279/315.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPA
..  | .||..|||| . |. || |..|     . ...||||.|.||.|....|||.| |.  .|.||||......   ||||...  ...  . .||| 
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

GdEALIGPFVIDVSAEEREGDVIIRTFllsntNTVATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRDLGnGPITVHCMDGVTRSGLFCAI
  . . |.. .    || . .. .||.      .|  .  | . |. .  |    . ||.  .|. |   |   . .   |.| ||| .|| |.| |...
k.kviyGkitvtrkseevnteytvrtl.....svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitl

MSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 . . ... |  |||.......|.   .|| . ||| .|.|.. | .
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
0045098 (Phosphotyrosine protein) phosphatases II 2384-2629 3e-58 192.7 In-house 25-272 (278) alignment 
Range on Protein: 2384-2629
Range on HMM: 25-272/278.0
MQAGKSSENHHKNRYPDNIPLDKYRPYlmtgcsegqtNYVNATFLDGFnrRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPA
.  .   .| .||||.| .|.|  | .          .|.||...||.  .. .|||| ||..||.|||||.......|||||.|   .. . | |||| 
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTV-ATESSRVIRQYSFVGWKERqKYPKSL--ASLLCLLDLVEAGQR------------DLGNGPITV
|.   .|.|.. .  ||. .|...||.|. |...  ..  || .... ...| .    | .   .|.| ||. ... ..            . ..||. |
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllsslllldsggpvlV

HCMDGVTRSGLFCAIMSTIGKLksEGNIDVFHAVKKLRKCSGR-MVPSEEQYLYIHDVVREYL
||. || |.| ..|..  .  |  ||..|...|||.||.. .  .|...||| .......|.|
HCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPRG_pd Subfamily PTPRG 2376-2633 3.4e-58 192.2 In-house 31-291 (563) alignment 
Range on Protein: 2376-2633
Range on HMM: 31-291/563.0
SIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCS-EGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRND
 .  .|. ... .  ||..|||| . .. |. |  |      ... .|.|| ..||... . .|||| ||..|..||||||.. |...|||. .  .|. 
etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergr

QTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVATES---SRVIRQYSFVGWKERQKyPKSLASLLCLLDLVEAGQRDlGNGPITVHCM
. | .|||. .   .| . .   .||.     .||. . |..  ....    ...||| .  | . .  |.. .  |      .| ...   |||.||| 
rkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv.PehslpvLifvkkssaanka.eaGPivvHcs

DGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
 ||.|.| .... . . ....|  ..||. .|..|     .| .||||...||.. | .|| |
aGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2094-2341 5.9e-58 191.0 In-house 25-273 (283) alignment 
Range on Protein: 2094-2341
Range on HMM: 25-273/283.0
WEVATRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVS---GYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
 ..|. .||  |||. .|.|.|  || |....     |||||.|.     | . | ||..|.||  || |||.||..|..  ||||||| |... ||  |
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPED-IETYGDFTLTVVAERNYLNYTERTLTIRKA-WDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTID
||..  | ||.||.|.  |     .. . |..|.     ..  . |. .  | ..|       |. |   .      . || .||||.|.|||... .. 
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaas

SMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSV
. ..    |  ..|   |  || .|. .||| .|| ...|. ||  ||| | .
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
subfamily_PTPN14_pd Subfamily PTPN14 2081-2333 8e-58 190.8 In-house 27-295 (300) alignment 
Range on Protein: 2081-2333
Range on HMM: 27-295/300.0
LDYERLPDGQMY-TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDApHEDYINASFVSGYL--KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLT
 .|||.|  ..  . ..|. .||..|||. ...||...|| | .  .. ...||||| ..  .  | . ||..|||| .|| |||.|||.. | .|||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KLVENKKRKCDPYWPED-----IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR-------
.  |. | |.  |.|..       ..| | .|    ..   .. ..|...     ||| | |. || ||| |.|   .. |... .|.    .       
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
   . | .|||||||||||   . | ..     ...|..   . |.|..|  .|||  || |.|..|.. 
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2350-2633 1.3e-57 190.2 In-house 15-288 (297) alignment 
Range on Protein: 2350-2633
Range on HMM: 15-288/297.0
FTRLEQTNLHTKrTFLEEHLSALDAMsIFYSDVSmqagKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRrdMYIATQMPLQHTVE
|. | |.| ||.  | || |  . |. |. . |.    .   | .|.|| . .| |. |  |    .. . .|||| |. |..    .|.|||| . ||.
fatlvqknrhtd.vfseeflclpean.iqpqtva....ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatva

DFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERQKYP-KSLASLLC
|||.|..|.. ..|||||. |..|. | .||.    .  |  .. ... ..    | |.. ... ..    . ||..|| || | ...    .| .||| 
dfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgka...karrvvkqyqfveWPdkaverkdsassllk

LLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
|.. |.    .  .||. |||. || | |....| | . . | | ..|.|  |||||.    .|  .||| ... .| |.| | .
lisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_CG7180_pd Subfamily CG7180 2386-2629 1.5e-57 189.5 In-house 36-290 (296) alignment 
Range on Protein: 2386-2629
Range on HMM: 36-290/296.0
AGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDE
.|  .||  |||... .| |. |..| .   | ...|.||.. |.| .   || |..| ..||..|||..|| ... .|.| .     . . .|||   .
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnksk

ALIGPFVIDVSAEEREGDVIIRTFLLSNT-------NTVATESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEAGQRDL----GNGPITVHCMDGVT
.  |......  |.   .. |||| |  .       ..  .   |..... .  |.  .| | | ..|. |.  |.  ..       .||. |.. ||..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
||| ..||  .. ... |...|||.|||.||.   ..| . |.| || ||. |..
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2089-2331 1.6e-57 189.5 In-house 25-274 (287) alignment 
Range on Protein: 2089-2331
Range on HMM: 25-274/287.0
GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPhEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCD
.  .|.  |.   .|.|||| ...|.|..||.| ....    ||||| .|..| . .|.||.|||...|| ||||.|...|. .....|. ||. . || 
sstatfkaaeelaavkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

PYWPEDIE--TYGDFTLTVVAERNY-LNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKE-----FEARPSGPTIVHCSAGVGR
 ||||       | ......   .   .|. |.| . ..   | | |. ... |||| .|. .|  |. |. .||.      .|   || .||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
.|.....  ....     ...|   | |.| .|  .||.. |. ..|||| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2385-2630 6.9e-57 187.7 In-house 37-278 (315) alignment 
Range on Protein: 2385-2630
Range on HMM: 37-278/315.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPA-
.... ..|..|||| ...|||. |  |     . . .|.||... ...    |||.|.||. .|.|||||.....   |||... ...|.  | ||||  
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTntvatESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGqRDLGNGPITVHCMDGVTRSGLFCA
 .| .  | . ...   |  .| ..| . . ..     |.|| . |. | .| ..   .| ..||| |.  | |  ..  . .. |||. || |.|....
kadsvefGsikvellsleadtdgvarklvtrks.....eesrtvtqfqftewPdkG.vdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvis

IMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|.. . ..| .  .|||. ||.||.    .| .||.| .|.|.|.|.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRB_pd Subfamily PTPRB 2363-2631 3e-55 182.3 In-house 26-287 (293) alignment 
Range on Protein: 2363-2631
Range on HMM: 26-287/293.0
TFLEEHlsalDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNV
 | ||.    . .. . .| ...| ....|. |||| . .| |. |  |..  .| ...|.|| ...|.| .  .|||| || .||.|||||... .|..
rfseey....eelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLNEINRND-QTCSQYWPAG-DEALIGPFVIDVSAEEREGDVIIRTFLLSNtntvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAG-QRD
|||| ..  .  . | .||||  .. | |   ... |||.  | .||......     ....| .||| |. | .    |.. ..|| ..  |.   ...
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdh.gvPektktlldfvrtvreaiekt

LGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLAS
  ..||.|||  || |.| | |.   . ....|  .|.|  | .||.    .| .|.||..||..| ..| .
askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0041856 (Phosphotyrosine protein) phosphatases II 2102-2341 6.3e-55 180.9 In-house 1-178 (182) alignment 
Range on Protein: 2102-2341
Range on HMM: 1-178/182.0
NVSKNRYINIIPYDHSRvildtdpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTklvenkkrkCDPYWPedietygdf
|..|||| .|.||||||          . |||||... |.|... .|||||||  || ||.||...... .||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

tltvvaernylnytertltirkawDPEERRVQHFHYTSWPDMGLPLsATPLLEFITKVKEfearPSGPTIVHCSAGVGRTGTYFTIDSMMDMsareqQIN
                        . .|| . ...|..|||.| |     ||.|| .|.|    ..||..||||||||||||.  .. |. .     ...
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

VLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSV
. . |  .| .| .||.||.||.|.. |||| ||...| .
leeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2367-2630 8.9e-55 180.7 In-house 22-277 (515) alignment 
Range on Protein: 2367-2630
Range on HMM: 22-277/515.0
EHLSALDAMSIFYSDVSmqagKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML
| .  |    |.   |.    .   |..|||| ...|.|. |  |     . . .|.||... .|.    |||.|.|.. .|.||||.....|   |.|.
eefhdlpgpniypqtva....qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

NEINRNDQT-CSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLsntntVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRDLGnG
.. ...|.  |..|||   ||    | . ... . |  .. |.|.. .     .  . || . |. | .| ..   ||   ||| |.  | | .  .   
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.....lkgddsrtvtqfhfteWPdkG.vpkhtssllklikevkadhgqyt.h

PITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|. .||. || | |....|.| . . |    .|||. |...|.    .|  .||| .|...|.|.| 
pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0037934 (Phosphotyrosine protein) phosphatases II 2386-2629 1.1e-54 180.9 In-house 4-242 (243) alignment 
Range on Protein: 2386-2629
Range on HMM: 4-242/243.0
AGKSSENHHKNRYPDNIPLDKYRPYLmtgcsEGqTNYVNATFLDGFNRrdmYIATQMPLQHTVED----FWRMIYDYNSNVIVMLNEIN-RNDQTCSQYW
 ... ||..||||.| .|.|  | .|     || ..|.|| . ....|   .||||.||..||||    ||||.......|||||.|   .. . | |||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PagDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVATEssRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRD-------LGNGPITVHCMDGV
|  .|  .|.|.. .  ||  .|...||.||.|...   .  | ...| ...|   .. | | ..|| .|| | . ...        ..||. |||. ||
p..gevtygdftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

TRSGLFCAIMSTIGKLksegNIDVFHAVKKLRKCSGR-MVPSEEQYLYIHDVVREYL
 |.|...|.   . .|    ..|...|||.||.. .  .|....|| .......|.|
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
0051429 (Phosphotyrosine protein) phosphatases II 2128-2355 7.7e-54 178.4 In-house 2-245 (272) alignment 
Range on Protein: 2128-2355
Range on HMM: 2-245/272.0
PHEDYINASFVSGYLK---PKAYIATQGPLSTTVFDFWRMvWQERVPVIVMLTKLVENKKRKCDPYWP-------------EDIETYGDFTLTVVAERNY
| ..||||..|.|| .   |.......|||  |. ||||. ..... .||.|....| .. |||.|||             .   .||....|.. | ..
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

LNYTERTLTIRKA-WDPEERRVQHFHYTSWPDMGLPLSAtpLLEFITKVKEfearpSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQIN--------V
|.|. |.|....     | |.| |.|||.|||.| | .|  |||..  . .     .|| .||||||..||||.  .. ..    .|. ..        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LDFVYRMRTKRVKMVQTPEQYVFIYEALLEClLCGYTSVPTKTIVQYFTRLEQ
...| ..| .| ..|||.|||.|.||||||  |....||.  .. .... ...
eeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_PTPN12_pd Subfamily PTPN12 2381-2630 6.3e-53 174.5 In-house 29-278 (290) alignment 
Range on Protein: 2381-2630
Range on HMM: 29-278/290.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQY
 .| .||...|| .|||| | .| || |  | .  .| . .|.|| |. | . . .|||.| || .|..||||||...| ...||. .|.. . . | .|
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPAGDE-AL-IGPFVIDVSAEEREG-DVIIRTFLLSNTntvatESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRdLGNGPITVHCMDGVTRS
||   | .| .|.| .....|..   | .|||. . .      . ||...|. .  | ...  |.|  ||| |..||.  |.   . |. |||  || | 
WpeegeeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhg.vPssaksllelielvrelqe.sedaPlvvhCsaGvGrt

GLFCAIMSTIGKLKSEG---NIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|  .||  .   ||.|    ..|||. | .|||    .| ..||| ...  | |.. 
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2074-2336 4.2e-52 171.7 In-house 12-295 (301) alignment 
Range on Protein: 2074-2336
Range on HMM: 12-295/301.0
NGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPD--APHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVP
. .  |. .|..| .|.  . .| ...||   ||. || .||. |.|| . |.    ...|||||...|| . |..||.|||.  |. ||||..|||.. 
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

VIVMLTKLVENKKRKCDPYWPE---DIETYGDFTLTVVAERNYLNYTERTLT-----------------IRKAWdpEERRVQHFHYTSWPDMGLPLSATP
 |||.|.| |..| ||  |||.   . |..| || |.| | .| ... | |.                 ....   . . |  .. |.||. |.      
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt

LLEFITKVKEFEARP-SGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
 |. | .|   . ..  || .||||..|.|.|.| ...  ..   .|  ..| . . ..| .. ..|.| |||..||... . | .
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2389-2627 7.5e-52 171.6 In-house 58-289 (319) alignment 
Range on Protein: 2389-2627
Range on HMM: 58-289/319.0
SSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNeinrnDQTCSQYWPAGDEALI
  .|  |||. . .. || .  |     |  ..|.||.|..|. |.|.|||.| ||. |..||||||..||.  ||.|       . ||||||   .   
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivike

GPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLV-EAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIG
. | ..|.. |   . ..| . ||.      .  | |.|. | || .    |.. . |..|.. |    ..  .. .| |||  || |.| . ..   . 
erfkvkvdsveetaeyvvrdielsedgk..ekdirkitqfhflGwpdvG.vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

KLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
..| |  .||.. |. ||.   ..| .  || .|.  . |
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2390-2627 2e-51 170.2 In-house 23-253 (284) alignment 
Range on Protein: 2390-2627
Range on HMM: 23-253/284.0
SENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNeinrnDQTCSQYWPAGDEALIG
 .|  |||. . .. || .  |     |  ..|.||.|. |. |.|.||||| ||. |..||||||..||.  ||.|      .. ||||||   .   .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikee

PFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLV-EAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGK
 | ..|.. |   . ..| . ||.      .  | |||. | || .    |.. . |..|.. |    ..  .. .| |||  || |.| . ..   . .
rfkvkvdsveeseeyvvrdielsedgk..ekdirkirqfhflgwpdvg.vpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
.| |  .||.. |..||.   ..| .  || .|.  . |
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2095-2332 4e-51 168.4 In-house 49-281 (290) alignment 
Range on Protein: 2095-2332
Range on HMM: 49-281/290.0
EVATRQENVSKNRYINIIPYDHSRVILDtdpDAPHEDYINASFVSGyLKPkAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED
..  .. .. |||| ...  | .||||.   |  . ||. | .| | ||.  .| |||.|  ||.|.|||| ||.| .|||| .|.|. | ||..|.|| 
kifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkG.lka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

---IETYGDFTLTVVAERNYLN-YTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFearpSGPTIVHCSAGVGRTGTYFTIDSM
   . |.|..|..   | .  .    .||..|.  .  | ...|..  ||||  ..||.  ||  .  ...     ||| .||||||.|||||. .|.  
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievg

MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
...    .....|| |  .|  |.. ||   ||. . |.||.
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2381-2628 8.7e-50 164.2 In-house 22-265 (283) alignment 
Range on Protein: 2381-2628
Range on HMM: 22-265/283.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSegqtNYVNATFLD---GFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTC
| . .   ..||..|||. . .| |..|  | .       .|.||.|.      ..   ||..| ||..|| |||.|..| .   |||| ..  .  . |
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

SQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWKERQKYPksLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRS
|||||       |.| . .  |  .   ||. .|| .    ...|. ..  | ...| | .. .      |  ...| . |..  .||| |||  |. |.
sqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..ssakstlllahyqvidWleygeqa..iinslvkfnkvislqteskkgPivvhCstgiGrt

GLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
. |.|..... ....|  .|||  || .|.    .| . .||  .|..| | 
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_PTPN6_pd Subfamily PTPN6 2339-2631 2e-48 159.9 In-house 2-299 (306) alignment 
Range on Protein: 2339-2631
Range on HMM: 2-299/306.0
TSVPTKTIVQYFTRLEQTNLHTKRTFLEEHLSALDAMSiFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMtGCSEGQTNYVNATFLDG--FNRRDM
||. .|.| |  ..||... ..... .||.  .|. .    . .| . |.  ||..||||   .| |. |  |    |  ...|.|| ....   . .  
tsllakeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdks

YIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYWPAG-DEALIGPFVIDVSAEEREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWK
|||||  |..||.|||||... ||.||||. .|..|. . |..|||.  ..   |   .   .|..  | |.|....|..     ...| ..|| |  | 
yiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWP

ERqKYPKSLASLLCLLDLVEAGQRDLG---NGPITVHCMDGVTRSGLFCAI---MSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
.    ||.   .| .|. |.. |..|    .||| ||| .|. | | |  |   ...| | . . .||. ..||..|.    .|  |.|| ... ....|
dh.gvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

LAS
. .
iet
0036282 (Phosphotyrosine protein) phosphatases II 2130-2328 7.2e-48 157.9 In-house 2-164 (174) alignment 
Range on Protein: 2130-2328
Range on HMM: 2-164/174.0
EDYINASFVSGYLKPKAYIATQGPLSttvfdFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEdietygdftltvvaernylnytertltirkAWDPEE
.||||||.....  .. .||.||||.     ||.|...... ..|||....|... ||  ||||                               .. .|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RRVQHFHYTSWPDMGLPLSATpLLEFITKVKEFEAR-PSGPTIVHCSAGVGRTGTYFTIDSMMDMSArEQQINVLDFVYRMRTKRVKMVQTPEQYVFIYE
| . ...|. |||.| | ... ||||.  |.|. .. |.||..||||||||||||   .. |. .   |  ...||.|...|..| .|||||.|| |.|.
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2390-2630 1.5e-46 153.7 In-house 26-269 (274) alignment 
Range on Protein: 2390-2630
Range on HMM: 26-269/274.0
SENHHKNRYPDNIPLDKYRPYLMTGCSEGQ-TNYVNATFLDGFNRR-DMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN-RNDQTCSQYWPAGDEA
. ...|||| . .| .. |  | .  || . ..|.|| .. |....  .|.||| ||..||.|||||||  ...||||| ... .| | |..|.|   ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----LIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaT-EssrvIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQR--DLGNGPITVHCMDGVTRSGLF
      | . | |.   .. |  .|...|....   . .    .  | .  | . .| |..  .|| |.. ||  ..  .   .|. |||  |. | | |
eiserygdveikvekiverndysvrklvlkyler..ers....vkhywytdWPd.hksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 ||  .. .|. |. .||.. | .||   | || ..||| .|| .. .|| 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0049772 (Phosphotyrosine protein) phosphatases II 2093-2335 3.5e-46 153.7 In-house 37-281 (314) alignment 
Range on Protein: 2093-2335
Range on HMM: 37-281/314.0
TWEVATRQENVSKNRYINIIPYDhSRVILdTDPDAPHEDYINASFVSGYlkpKAYIATQGPLSTTVFDF----------WRMV--WQERVPVIVM-----
|. ||   .| .||||..|.|.| .||||    .    ||||||.|.|.   ...|||||||. ||.||          ||||  .. .| .|||     
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTKLVENKkrkcDPYWPEDIETYGdftlTVVAERNYLnytertltirkawdpeERRVQHFHYTSWPDMGLPlSATPLLEFITKV
                |..| .|     . ....|.|..     ... .....                ||.. ..... .|| . | .   ..||.  .
ladelsrLdaAlgKtpllildgng....neptaadlellk....eelydpelf................erlgikylripvpDgsap.lledfdeflefi

KEFeaRPSGPTIVHCSAGVGRTGTYFTIDSMMDMSareqQINVLDFVYRMRTKRV-----KMVQTPEQYVFIYEALLECLL
.|.  .. ||..|||.||.|||||. ... .|       .... . . ..| ||       .....|||.||.||||| | 
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0043147 (Phosphotyrosine protein) phosphatases II 2128-2328 5.7e-46 151.7 In-house 3-155 (172) alignment 
Range on Protein: 2128-2328
Range on HMM: 3-155/172.0
PHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLvenkkrkcdpywpedietygdftltvvaernylnytertltiRKAWDP
...||||||....| .|. .|||||||. |. |||||.... . .||.||.|                                           . ...
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

EERRVQHFHYTSWPDMGLPlSATPLLEFITKVKE-FEARPSGPTIVHCSAGVGRTGTYFTIDSMMdmsareQQINVLDFVYRMRTKRVKMVQTPEQYVFI
.|| . ...|..|||.| | ..  ||||.  ..| .  .|.||..||||||||||||   .. |.      ....... |  .|.|| ..||.|.|| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

YE
|.
yy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2381-2630 1.8e-45 150.3 In-house 30-277 (281) alignment 
Range on Protein: 2381-2630
Range on HMM: 30-277/281.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQY
| . .| |. || .|||| . .  |. |  .    .. .|.|.|| |..|..    ||||| |. .....||.|..... ..|||. .||. .   | .|
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

WPAGD-EALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGL
|| .. |  .| ...   |||..   | |.| |....      .| ..|  .. | .    |.. . ||   . |.  ..   . |. .||  || |.| 
WPddnselkygdvtvkstaeeekatyierkfkleres....getreveqlaytaWPdh.GvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

FCAIMSTIGKLKSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
. |.   . ....|  ..||   |..|||    || .  || ... .| ..| 
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2380-2637 4.3e-45 148.7 In-house 28-301 (301) alignment 
Range on Protein: 2380-2637
Range on HMM: 28-301/301.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTG--CSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTC
.| |.. | |.||.. ||. .. ..|. |  | .    .  |..|.||...||....  .||.| |...|. ||||.|...    |||. . . .  . |
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

SQYWPAG--DEALIGPFVIDVSAEEREGDVIIRTFLL-----SN-------TNTVATESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEAgQRDLGN
 |||| .  ..   ||| . .. |    | .|| . .     ||        .. .. ||. . |.  . | .    .     |  . | . . |.  | 
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihr.qqkigg

GPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYEN
||. ||| |.| ||| .|..  ..   |.|| .|||  .| .|.    .|   |||  |.||. .||.  ..| |
gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_PTPN9_pd Subfamily PTPN9 2385-2629 1.6e-44 147.1 In-house 35-290 (297) alignment 
Range on Protein: 2385-2629
Range on HMM: 35-290/297.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPAG
.| |.  | .|||| | . .|. |  | .   . ...|.|| |.||..... .|||| ||..||.|||||... .  ||||   . .|    |.|||| .
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DEALI--GPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQR------------DLGNGPITVHC
.|. .  | . . .   | | |  .|.. ..|..   || || .  . |..| .    |.| |||| .|. |   |             .. . || |||
eessaefgdlsvsnveveeeedykvrvleiknvk...teesrkvthfqflsWPdy.GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

MDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
  |. |.| |...  .. .|...|..||...||.||.    ..  .||| . .  | || 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2100-2332 2.1e-44 146.6 In-house 31-257 (267) alignment 
Range on Protein: 2100-2332
Range on HMM: 31-257/267.0
QENVSKNRYINIIPYDHSRVILDTDpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYG
..|  .||. . .|||..|||| |      |.|||||.| || . .|.|.||.||. |. ||. .. ...|||||.|||  ... |.  |    . . | 
eknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyq

DFTLTVVAERNYLNYTERTLTIRKAwDPEERRVQHFHYTSWPDMG-LPLSATPLLEFITKVKeFEaRPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQ
|.|.    |..  .|   || ..   .   . |  ..|  |           ||.  ..| . .|   . | .|.||.||||.||...|||...   .|.
dltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgilaknq.le.ngnrPlvvacsdGvGrsGtflvidsqlerakteg

QINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
  .. ||. ..| .|. .|.| |.|..|.| | |
vsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2097-2338 4.8e-44 145.6 In-house 36-281 (307) alignment 
Range on Protein: 2097-2338
Range on HMM: 36-281/307.0
ATRQENVSKNRYINIIPYDHSRVILDTDPDAphEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED--
 . . |  |||| ..   |..|... .|  |   ||| | ..   .||| .|..|||| .|...|| |. ||.|  ..|| |..|  | ||. ||| .  
eafsantdknryqdvkcqdkgrivvkfdgla..sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

-IETYGDFTLTVVAE---RNYLNYTERTL---TIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEfearPSGPTIVHCSAGVGRTGTYFTI
   ..|. . |.  .    . |   |  .   |..  |  . | .||. .. ||| | |      ....  |.        | .|||||||||.||  .|
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivai

DSMMD-MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
  ..| | | .   .. ..|  .|..|   .||  ||....  ||| .|  |
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
0049260 (Phosphotyrosine protein) phosphatases II 2137-2328 4.4e-43 141.9 In-house 1-144 (152) alignment 
Range on Protein: 2137-2328
Range on HMM: 1-144/152.0
FVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWpedietygdftltvvaernylnytertltirkawdpeerrvqHFH
|..|| .|...||||||.. |. |||||...  . .|||||.|.|..| ||. |.                                          ...
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

YTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMdmsareQQINVLDFVYRMRTKRVKMVQTPEQYVFIYE
.. |||.| | ..  ||...  ....  ...||..||||||||||||.  .. |.      ........| ..|.|| ..|..|.|. |.||
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2093-2334 6.4e-43 141.7 In-house 24-295 (297) alignment 
Range on Protein: 2093-2334
Range on HMM: 24-295/297.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPdaPHEDYINASFVSGY--LKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
.. .| |.  . |||| .|. .| .|| |   .  . .||||| .|      ..  || .|||||.|| |||..|... | ||||..|| |. . || ||
sfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WPEDI---ETYGDFTLTVVAER----NYLNYTERTLTIRkawdPEERRVQHFHYTSWPDMGLPLS----------------ATP-LLEFIT--------K
||.      . ||. .  ...     . .  || .|  |     |.| |.|  . |||| |.|                  | | .|  .         .
wpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflq

VKEFEARP--SGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
.. ..|    . ...|||||||||.|     | ....  ...  .|  ..  .| .| ..||| ||. ..|.| |. |
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_PTPN3_pd Subfamily PTPN3 2380-2625 1.6e-42 140.3 In-house 29-271 (280) alignment 
Range on Protein: 2380-2625
Range on HMM: 29-271/280.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFL----DGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQ
 .....| . .|| .|||| | .| |. |  |     |..|.|.|| ..    .. .    ||||| ||..|..|||.|... .|..|||| . ..|  .
pglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

TCSQYWPAG-DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAgQRDLGNGPITVHCMDGV
 | ||||   ||   | | . .. |...  ...| ..|....|   . .| | |  .. | .  . |.. |..| ... |.. .|   . |. |||  |.
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdket...keerkilqlqylaWpdh.gvPddsadflefvervrk.lrsgkeePvvvhCsaGi

TRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 |.|.. ..  .. .. .. .. . . |...|   . .|....|| .. . .
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
0046846 (Phosphotyrosine protein) phosphatases II 2126-2332 6e-42 138.7 In-house 8-171 (176) alignment 
Range on Protein: 2126-2332
Range on HMM: 8-171/176.0
DAPHEDYINASFVSGYLkpkaYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGdftltvvaernylnytertltirkaw
. .. |||||... |..    .|||||||  |. ||..|...... ..|.||..|| .. ||. ||||  .                             
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

dpeerrvqHFHYTSWPDMGLPLSaTPLLEFITKVKEFEARPsGPTIVHCSAGVGRTGTYFTIDsmmdMSAREQQINVLDFVYRMRTKRV-KMVQTPEQYV
        ..... |||.| | . . |||..  ..|.  .  ||..||||||.|||||.  ..    .  .|....|.. ....| .|  ..||||||| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIYEALLE
|.||..|.
flyefell
subfamily_ptpA1_pd Subfamily ptpA1 2099-2292 6e-41 135.5 In-house 44-254 (418) alignment 
Range on Protein: 2099-2292
Range on HMM: 44-254/418.0
RQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYlKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE--
.. | ||||| ||.| .|.|| |    |    ||||| .. |   || .|.|||||  |. |||||||..|. .||||..  || . ||| ||||.|   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

---TYGD----FTLTVVAERNYLNYTER---TLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEF--EARPS----GPTIVHCSAGVGR
    ||.    |    |   . ..  ||   |  || ... | | . ...|  |||  .|  . |. ...  . .   .  ||     | ||||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYFTIDSMMD
|||. |   || 
tgtfctavimmk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2101-2332 3.3e-40 132.7 In-house 47-285 (305) alignment 
Range on Protein: 2101-2332
Range on HMM: 47-285/305.0
ENVSKNRYINIIPYDHSRVILdtDPDAPHeDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGD
..  |||| ..   |. || |  ..  || .|| | .||   .|| .| || ||  |  ||| | .|..|  | || .|.|   .||  |.. . .   .
qeagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

F-----TLTVVAERN---------YLNYTERTLTIRKAwDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKvkefeARP-SGPTIVHCSAGVGRTGTYF
|      ..|  |             . ||  |.|  .   . |.|.|.|.  ||| |.| . . .||...|     |||  ||..||||||.||||.  
feekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellek.....arpskgpivvhcsagigrtgsvv

TIDSMMDMSAREQQINVLD-FVYRMRTKRVKMVQTPEQYVFIYEALLE
 .. ..|     |.|.  |  . ..| .| . .|| .||.|... .|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2096-2332 6.7e-40 131.5 In-house 31-267 (281) alignment 
Range on Protein: 2096-2332
Range on HMM: 31-267/281.0
VATRQENVSKNRYINIIPYDHSRVILDT-DPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED
|  .  |  ||||.||   | ||| |    |.    ||| | ..   .  . || ||||   |  |||||.|||    |||| ...| .. ||  |.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

IETYGDFT-LTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKefeARpSGPTIVHCSAGVGRTGTYFTIDSMMD-
     .|  |.|  |   .| .  |  .  ... | | . |. .  |||  .| |.  .|. . |..   || | | ..||||||||.|| ....  .. 
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir...ar.stppvihcsagvgrsgtlmaveialqs

MSAREQQINVLDFVYRMR-TKRVKMVQTPEQYVFIYEALLE
. ..    .. . | ..| | |   ||| .||..|.. ||.
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2383-2635 8e-40 131.4 In-house 29-284 (287) alignment 
Range on Protein: 2383-2635
Range on HMM: 29-284/287.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGqTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYWP
 ..| .   . .|||| | .|.|. |  | .    | ..|.|| .. .... . .||.| |.  || ||||.... .| .....  |..   . | .|||
tfkaaeelaavkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

AGDEA-LIGPF-VIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERQKYPKSLASLLCLLDL---VEAGQRDLGNGPITVHCMDGVTRS
  .   ..| . |. .. . .| .  .|.. | . .   |. .||..|. .. | ..   | ... .   ||    .|. .   . ||. ||.  |. ||
erevPmrvGGysvvlldydikePeygvralrlidle...trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR-EYLASCEIY
|.. |..  . .|.. |..||  .| .||.    .| .  |. .. . .   | .  ..|
GillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqly
subfamily_PTPRN_pd Subfamily PTPRN 2375-2627 3.4e-39 129.3 In-house 38-290 (297) alignment 
Range on Protein: 2375-2627
Range on HMM: 38-290/297.0
MSIFYSDV-SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFL-DGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN
.  . ..  . ...|. .| .|||. . .| |. |  | .  |. ...|.||... |   |. .||||| || .|| |||.|...  . |||.| ... .
lcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleee

D-QTCSQYWPAGDEALIGPFVIDVSAEE-REGDVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDlGNGPITVHCM
. . |..|||   ... . . ... .|     | ..|.| | | .|   . .| . |. |. |.|.   | |  ||| .   |.   |     || |||.
gvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt...setrtvtqfhflswpee.gvPasaksllefrrkvnksyrG.rscpivvhcs

DGVTRSGLFCAIMSTIGKL-KSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
||. |.| ...|   . .| |   .||.  ....||     .| ...|. ..  .| |
dGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2376-2628 3.8e-39 129.3 In-house 19-258 (267) alignment 
Range on Protein: 2376-2628
Range on HMM: 19-258/267.0
SIFYSDVSMQAgkSSENHHKNRYPDNIPLDKYRPYLMTGCSEgqtnYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDqt
|   | .|     ...|. .||. ||.| |. |  | |   |    |.||....|.... ..|.|| ||. |. ||. .| |..  |||.|  .  ..  
sdtsstisqsi..aeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..

CSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRVIRQYSFVGWKERQKYPKSLASLlclLDLVEAGQRDLGNGPITVHCMDGV
  ..||   |.      .... | |. | |  | |. |   |    ||.. .  | .  |.   .    |  |   . ..   | . || |. |.| |||
irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn....esahnvtlyyykkwnintnnkpylkpl...fgilaknqlengnrPlvvacsdGv

TRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
 ||| |  | | . ..| ||  |.|. ..|.|.    .| . |.|.|||... ||
GrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0041856 (Phosphotyrosine protein) phosphatases II 2392-2629 2.9e-38 126.7 In-house 1-171 (182) alignment 
Range on Protein: 2392-2629
Range on HMM: 1-171/182.0
NHHKNRYPDNIPLDKYRpylmtgcsegQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNeinrndqtCSQYWPagdealigpf
|..||||.| .| |  |            .|.|| ...|  . . .|||| ||..||.||.||..... ..||.|.        . .|||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

vidvsaeeregdviirtfllsntntvaTESSRVIRQYSFVGWKERQKYPksLASLLCLLDLVEAgqrdlGNGPITVHCMDGVTRSGLFCAIMstigkL--
                           ..  | . || ...|      .  | .|| ... |..      .||. |||. || |.| ..|.      |  
...........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaay.....lmk

-KsegNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 .   ......||| .|..   || ...|| .......|.|
kl...gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2360-2629 3.2e-38 126.3 In-house 17-279 (439) alignment 
Range on Protein: 2360-2629
Range on HMM: 17-279/439.0
TKRTFLEEHLSALDAMSIFYSDVSMQAGKsSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYN
 |. ...| .  ....|  |. ..  | . . .. |||| |  ..|  |  |       .. |.|| ...|.   ..|||||.| ..|..||||.... .
nkqeifkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

SNVIVMLNEINRNDQtcsqYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRD
.  |||| ..    .    |||. .|.  |  .. |  .    . .|| | . |     ||  | . |. .. | ...  |   . .| .|  ... . .
tvtivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerd.ttekertvlqfhyiawpdkn.vpaqashvldflrainsandk

LGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
   ||. |||  || |.|   |.  .. .||.| ..|.   || |||   .|| .  ||..|.. | | .
eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2100-2338 1.5e-37 123.9 In-house 53-293 (305) alignment 
Range on Protein: 2100-2338
Range on HMM: 53-293/305.0
QENVSKNRYINIIPYDHSRVILDTDPdapHEDYINASFVSGYLKP-KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETY
. ...|||| ..   |.| | ||  .     ||| | .|   . | | .|..||||  |. .|| || |..|  |||| | ||  | ||  |||      
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

GDFTLTVVAE----RNYLN-YTERTLTI-RKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMM
 ..   .| |     . ..  .|  .|. . ..   ..  |.|...| ||| |.|      ||... ..  .     | .||||||.|||||  .|. ..
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhcsagigrtgtivaieyil

DMSAREQQIN-VLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
.  | ...   . ..|  .| .|   .|.  ||.||.  .|. .|  |
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2390-2626 1.7e-37 123.9 In-house 1-236 (237) alignment 
Range on Protein: 2390-2626
Range on HMM: 1-236/237.0
SENHHKNRYPDNIPLDKYRPYLMTGCSEgqTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAGDE-A
|||. |||| . .  |. |  |    |.  ..|.|||.|.||.     |||.| ||. . .|||.|... .  |||||   |..|.. | .|||  |. |
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

LIGPFVIDVSAEEREGDVIIRTFLLSNTNTVAteSSRVIRQYSFVGWKERQkYPKSLASLLCLL-DLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMST
  | . . .  .|   |  .|..|||.  |.     |.| || |  | .|   |.  |.|| .  ....  .     ||  .||  || |.|.|  | . 
aygvltvslkkkeefsdytvrslllskrltlk..evrlihqyqftswpdrg.vpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

IGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
. . | .  .|..  |. . .    .. ...||..||... 
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPN13_pd Subfamily PTPN13 2383-2630 2.7e-37 123.5 In-house 28-270 (273) alignment 
Range on Protein: 2383-2630
Range on HMM: 28-270/273.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSegqtnYVNATFLDGFN--RRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EINRNDQTCSQY
. . ||. ||..|||| . .| |. |  |    .     |.||...       .  |||.| || .||.|||.|... ...||.|.  | ...   | .|
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPAGDEA--L-IGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRdlGNGPITVHCMDGVTRS
||   .      . . ...   ..  .  .|.. .....   .. || . .  || | .  . |.| |.|| ..  |   |.   .||| |||  |. ||
wPesknkklkvsnrlevellkvqkldgfvvralavkdse...sgesrevahlnfvkwPdh.gvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
| . .|   .| .. . ..|| . |.|||.    .| ...||.... .. | | 
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2389-2630 3.6e-37 122.8 In-house 17-265 (270) alignment 
Range on Protein: 2389-2630
Range on HMM: 17-265/270.0
SSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWPAGDEA
   ... ||| | .|  . |  | .  .. .|.|.|| .. ||.  .  |||.. ||. |...|||||.. ... |||. ...  . . |..||||  . 
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

LI--GPFVIDVSAEE-REGDVIIRTFLLSNtntVATESSRVIrQYSFVGWKERQKYPK-----SLASLLCLLDLVEAGQRDLGNG-PITVHCMDGVTRSG
 .      | | |.. .  .  |.| |  .      |. |..  . .. | ..   ..     |  .|| .|  | . ...| .. |. ||| .|| |.|
kvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

LFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
.. |.  ..  |......|| . ...|||    .|   ||| ... .|.||  
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN1_pd Subfamily PTPN1 2380-2608 6.2e-37 121.9 In-house 20-250 (290) alignment 
Range on Protein: 2380-2608
Range on HMM: 20-250/290.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQ
||..... |  ||. .||| |  | |. |  |     .....|.||....  . .  || || || .||. ||.|... .|  .||||.. ... . | |
sdfptreaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPAGDE--ALIGP---FVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKERqKYPKSLASLLCLLD-LVEAGQRDLGNGPITVHCMDG
||| |.|  .|.     . ... .|||.   ..|.. | |   . |. .|.| .. .. | .    |.| |..| .|  . |.|      ||  .||  |
ywPqgeeekellledtklkvkliseerksyytvrllelen...lktqetreilhfhyttwpdf.gvpespaaflkflfkvresGslssdvGpavihcsaG

VTRSGLFCAIMSTIGKLKSEGN---IDVFHAVKKLRKCS
. ||| || . . . ... ...   .|. . . .|||  
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyr
0044763 (Phosphotyrosine protein) phosphatases II 2113-2332 1.1e-36 121.5 In-house 1-169 (178) alignment 
Range on Protein: 2113-2332
Range on HMM: 1-169/178.0
PYDHSRVILDTDPDAPHEDYINASFVSGYlkpkAYIATQGPlsttvFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIEtygdftltvvaernyl
|.|..||.|.. .. .  ||||||.. ..     |.....|      |........ . .||.||. .|. . ||||||||. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

nytertltirkawdpeerrvQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMsareqQINVLDFVYRMRTK
                     ..... .||.| | .   .|||.  ..|. ... ||..|||||||||.||   .. |. .     .... . . ..| .
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RVkMVQTPEQYVFIYEALLE
|  .|..|.|. ..||  |.
Rp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2099-2335 2.3e-36 120.2 In-house 32-271 (285) alignment 
Range on Protein: 2099-2335
Range on HMM: 32-271/285.0
RQENVSKNRYINIIPYDHSRVILDTDpdapHEDYINASFVSGYLKP-KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE-
 . |   ||| ..   . .||.|         ||| ||..    |   .||.|||||  |. |||.|..||..  ..||  |.|    ||  |.|| .  
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

--TYGDF--TLTVVAERNYLNYTERTLTIRKAWDP--EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARpSGPTIVHCSAGVGRTGTYFTIDSM
   .| .  ||| . |         .||. .. |   |   ..| .   |||   |  | |..|.   ||. . .   |  |||||||||| |.  ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidya

MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
      . .|..|| |  ||. |.. ||.  |..|.|  |.| ..
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_PTPN23_pd Subfamily PTPN23 2390-2626 4.7e-36 119.1 In-house 41-277 (288) alignment 
Range on Protein: 2390-2626
Range on HMM: 41-277/288.0
SENHHKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAGD--E
  . .|||. | .| |. |  |     ... .|.||.|. .       .|||| ||| |. |||.|.|.  |.||||| .  ..... ...|||.     
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEA---GQRDLGNGPITVHCMDGVTRSGLFCAI
   |.. . .. ... . .. |.. |.  .   ..  . ..   .  | |    |.|  .|| .|| ||.    ..   . |. |||  || |.|.|. .
vkfgdlsvtlksvretethvervlkletld...adavksvshlqltsWpel.GvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

MSTIGKLKS-EGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
.. . .|.  .| .|. . |..||.    ||  .||.    ..| 
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2098-2329 1.1e-35 117.7 In-house 48-285 (310) alignment 
Range on Protein: 2098-2329
Range on HMM: 48-285/310.0
TRQENVSKNRYINIIPYDHSRVILDTDpDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE--DI
. .... |||| ...  | ||| |  |  . .|||| | .|      ...| .||||  |. |||||..|||   |..| | .|. . ||  |||     
aykkymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

ETYGDFTLTVVAERN-YLNYTERTLTIR--------KAWDPEERRVQHFHYTSWPDMGLPLSATPLL--EFITKVKefearpSGPTIVHCSAGVGRTGTY
||||   .| ..|    ..  . ..|.         .  . .| ||.  ..  |||.|.|      .   ....|.       || .||||||..|... 
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr......hgpcvvhcsagkdrlyvv

FTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEA
 ...  .| . | ..... . .  .. .|.. .||. ||..|   
valklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2100-2336 1.4e-35 117.7 In-house 41-273 (288) alignment 
Range on Protein: 2100-2336
Range on HMM: 41-273/288.0
QENVSKNRYINIIPYDHSRVILDTDPDAphedYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYG
 .| ...|| |.   | .|| |. |||     ||.|  ||    ..  | .| || .|.  .|.|. .. |  ||||..|.|  |.| . |.|  .    
ianptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

DFT---LTVVAERNYLNYTERTLTIRKAWDPEERR-VQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMMDMSA
 .      |  .|. .. . .  ..|     ||.  |.. |.  |.| |.| .  . | ... .|...     | .||.|||||||||   |  ....  
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlililialeslr

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
 . .. .  .. ..| .| | .||  ||....  .|| || 
lddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0051429 (Phosphotyrosine protein) phosphatases II 2420-2630 2.4e-35 117.9 In-house 4-226 (272) alignment 
Range on Protein: 2420-2630
Range on HMM: 4-226/272.0
TNYVNATFLDGFNR---RDMYIATQMPLQHTVEDFWRMiYDYNSNVIVMLNEINRND-QTCSQYWP------------AGDEALIGPFVIDVSAEEREGD
..|.|| ...|..|   .........||..|..||||. .... ..||.| . .  . . |..|||            .  . |.| ... .  ||   |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VIIRTFLLSNTNTVATEssRVIRQYSFVGWKERQKYPKSlasLLCLLDLVEAgqrdlgNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNID-------
.|.|..||... .  .   | .... . .|  .   ...   || ||.|. .      .||. |||. |. |.|...|.   .  .  |  .|       
yilrellltlllsagea..revmhlhytdwpdhgvpqea...llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 ...||..||..   .|..|||||.......|.| 
yleeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 2128-2331 8.5e-35 114.9 In-house 1-150 (151) alignment 
Range on Protein: 2128-2331
Range on HMM: 1-150/151.0
PHEDYINASFVSGYlkpkaYIATQGPLSttvfDFWRMVWQERVPVIVMLTKLVENKkrKCDPYWPE-Dietygdftltvvaernylnytertltirkawd
|..||||.|.| |.     .....|||.    ||....... . .||.|....|..  .|  |.|| .                                
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

peeRRVQHFHYTSWPDMGLPLSATPLLEFITKVKEfeaRPSGPTIVHCSAGVGRTGTYFTIDSMMDMsareqqINVLDFVYRMRTKRVKMVQTPEQYVFI
   ..| |.....||| |||||   .|||. .. .    ..||..||||||.|||||   .. |. .      ... . .  .| ||  .||...|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YEALL
. |||
lfall
PTPc_DSPc_SM00012 2232-2332 2.9e-34 112.8 In-house 2-105 (105) alignment 
Range on Protein: 2232-2332
Range on HMM: 2-105/105.0
VQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARP--SGPTIVHCSAGVGRTGTYFTIDSMMDMSARE-QQINVLDFVYRMRTKRVKMVQTPEQYVFIYE
|.|.|||.|||.|.| .....||.. .||...     |.|..||||||||||||. ..| ....  .| ........| ..|..| .|||| |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_PTPN14_pd Subfamily PTPN14 2381-2631 5.5e-33 109.2 In-house 38-298 (300) alignment 
Range on Protein: 2381-2631
Range on HMM: 38-298/300.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMtGCSEGQTNYVNATFLDGF--NRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCS
|  ....|  || .|||..| .| .. |  |.  . | .|.|.||. .      ..  ||..| ||..||.|||.|... . ..|||| |.. .  . . 
dallstaklpenaeknrfkdvlPyednrvels.ptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPAG----DEALIGPFVIDVSAEEREGDVIIRTFLLsntNTVATESSRVIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQRDL--------GNGPI
.|.|      ...  | | .     |  . || ... |   . . ..  | .    .. | . .. |. . . |  |. |.. .|           . |.
kyfPkleskkktvefgkfkvttkfsedsdsvittglkl...khlpskeertvwhlqytDWpd.hgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

TVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLAS
 ||| .|| |.|        |  |. . .||. .....||.    .|..  || ....|. .|| .
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0049772 (Phosphotyrosine protein) phosphatases II 2381-2629 6.6e-33 110.2 In-house 35-280 (314) alignment 
Range on Protein: 2381-2629
Range on HMM: 35-280/314.0
DVSMQAGKSSENHHKNRYPDNIPLDkYRPYLmTGCSEGQTNYVNATFLDGFnrRDmYIATQMPLQHTVEDF----------WRMI--YDYNSNVIVM---
. .. ...  .|..||||.| .| |  |  |  | .   ..| || ..|||  .. .|||| ||..||.||          |||.  .|.|. .|||   
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lk.fIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LNEINRNDqtcsQYWPAGDEALIGpfvidvsaeeregdviirtfllsntnTVATES---SRVIRQYSFVGWKErQKYPkSLA
                  |...  |      ...| | .|.                           .. ..    .| . .|  . .      | .|.
evladelsrLdaAlgKtpllildgng....neptaadlellk..........................eelydpelferlgikylripvpD.gsap.lle

SLLCLLDLVEAGqrdLGNGPITVHCMDGVTRSG--LFCAIMSTIGklksegNIDVFHAVKKLRKCSG-----RMVPSEEQYLYIHDVVREYL
 .. .|...|.      .||. |||..|. |.|  ...|..          ....  |.. .|..       ..... |||..|.....|||
dfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleyl
0036282 (Phosphotyrosine protein) phosphatases II 2420-2623 1.9e-32 107.7 In-house 2-164 (174) alignment 
Range on Protein: 2420-2623
Range on HMM: 2-164/174.0
TNYVNATFLDGFNRRDMYIATQMPLQhtvedFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAgdealigpfvidvsaeeregdviirtfllsntntVA
..| ||..||.. . . .||.| ||.     ||.|.........|||.| . ..   | .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

TESSRVIRQYSFVGWKERQKYPKSLasLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKsEGNIDVFHAVKKLRKCSGRMVPSEEQY
.  .| . || ...|  ..  . |   || ....||  . . ..||. |||. || |.|...|..  .  |. |. .|... |..||.. ..||....||
edlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

LYIHD
 ....
rflyy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2386-2626 2.3e-32 107.1 In-house 2-238 (239) alignment 
Range on Protein: 2386-2626
Range on HMM: 2-238/239.0
AGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAG
| |   |. |||| . .  |. |  |     . ...|.||..|  ..     |||||  .. .  |||||...    |||||   |.   . | ||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

DEALIgPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAgQRDLGNGPITVHCMDGVTRSGLFCAIM
       . . .   |   | |||||..|.   |     | . || |  | ..   |.  ...| |   .   .   |  |  .||  || |.| |  | 
tskyc.nlrvtlrktevfadyiirtfvmsq...vgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvid

STIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
. . . | .  .|.|  || .|.   .|| . |||..||  | 
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2388-2627 2.8e-32 106.8 In-house 3-238 (239) alignment 
Range on Protein: 2388-2627
Range on HMM: 3-238/239.0
KSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAGDE
|   |. |||| . .  |. |  |     . ...|.||..|  ..     |||||  .. .  |||||...    |||||   |.   . | ||||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

ALIgPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAgQRDLGNGPITVHCMDGVTRSGLFCAIMST
     . . .   |   | |||||..|.   |     | . || |  | ..   |.  ...| |   .   .   |  |  .||  || |.| |  | . 
kyc.nlrvtlrktevfadyiirtfvmsq...vgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidam

IGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
. . | .  .|.|  || .|.   .|| . |||..||  | |
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2105-2357 3.1e-32 106.5 In-house 46-296 (312) alignment 
Range on Protein: 2105-2357
Range on HMM: 46-296/312.0
KNRYINIIPYDHSRVILDTDpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP--------EDIE
 ||| ||  .|  |  |  |     . || | ||    ||. ...|||||  |.  ||...       |..|. .||.   ||  |          ||  
lnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

TYGDFTLT-VVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEfearPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA
 | ..     .  .   . | | | .      .| ...|. ..|||| |.| |    | ... ||        | | |||||||||||   |.||.    
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaalr

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLlcgYTSVPTKTIVQYFTRLEQTN
  .. || |    .|  | . |..  |||.   ..|| |   |.    |   | .|....| 
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl...yskglykrneqewtkfkety
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2228-2369 8.3e-32 105.1 In-house 87-229 (440) alignment 
Range on Protein: 2228-2369
Range on HMM: 87-229/440.0
EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE-ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFI
| | ....|| .||| |.|  | |.|..|  |.| .    .|| .||||||.||||   ..||..  . | .||... |.  || .| .||||||||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YEALLECLLCGYTSVPTKTIVQYFTRLEQTNLHTKRTFLEEHL
.||.|| |||| | .    |..   ...  | || .. |....
heavlegllcgdtliledditerveqiqwpnphtdksplqqef
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2133-2325 2e-31 103.8 In-house 78-272 (301) alignment 
Range on Protein: 2133-2325
Range on HMM: 78-272/301.0
INASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIET---YGDFTLTVVAERNYLN--YTERTLTIRKAW-D
| | ...   .|. .|||||||. |  ||| |. |  |  ||||.. ||....||. | | .|.     | |..... .   ||   ..||| .. .  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

PEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVF
 . | | |. |..|.| |.| | . | ...  ||. |     | .||||||.||. .. . . .      ...|.. . . ..| .| . ||| .|  .
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_CG42327_pd Subfamily CG42327 2103-2260 6.5e-31 102.2 In-house 29-191 (319) alignment 
Range on Protein: 2103-2260
Range on HMM: 29-191/319.0
VSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLK-PKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE-----DIE
  |.|.||..|  ..||.|.  .| ... |..||.| || . |  |||.| .|  .  ||||.||. .  ||| ||.| |.  ..|  |.|      . .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYtSWPDMGLPLSATPLLEFITKVK
.|||. .|.       .|   || ...  . | | . |. |  |.. ..| . ..|.  . .|.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
0043147 (Phosphotyrosine protein) phosphatases II 2418-2623 6.6e-31 102.7 In-house 3-155 (172) alignment 
Range on Protein: 2418-2623
Range on HMM: 3-155/172.0
GQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEInrndqtcsqywpagdealigpfvidvsaeeregdviirtfllsntNTV
. ..|.|| .||.    | .|||| ||..|..|||||..... ..||.|.|                                               . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

ATESSRVIRQYSFVGWKERQKYpkSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIgklkseGNIDVFHAVKKLRKCSGRMVPSEEQ
..  .| . || ...|        .|. || .|....  .    .||. |||. || |.|...|.   .       ......||. .|.. . .|....|
pellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YLYIHD
| ....
yrflyy
0046846 (Phosphotyrosine protein) phosphatases II 2418-2630 8.1e-30 99.3 In-house 10-174 (176) alignment 
Range on Protein: 2418-2630
Range on HMM: 10-174/176.0
GQTNYVNATFLDGFnrrdMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPAGDEALIgpfvidvsaeeregdviirtfllsntnt
.  .|.|| ...|     ..|||| || .|..||..|..... ...|.|.|    .   | .|||   .. |                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

vatessrvirQYSFVGWKERQKYPKslASLLCLLDLVEAGQRDlgNGPITVHCMDGVTRSGLFCAIMstigKLKSEGNIDVFHAVKKLRKCSG-RMVPSE
          || ...| . .  .   . || ||....  ...  .||. |||. |. |.|...|.      |..| ...|..|....|..   ..|...
..........qylhlpwpDhgvpdl..elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYLYIHDVVREYLA
||| .........| 
eQyrflyefellllk
0049260 (Phosphotyrosine protein) phosphatases II 2427-2623 8e-29 95.7 In-house 1-144 (152) alignment 
Range on Protein: 2427-2623
Range on HMM: 1-144/152.0
FLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWpagdealigpfvidvsaeeregdviirtfllsntntvatessrvi
|.||...  ..|||| |. .|..|||||..... ..||||.|   ..   | ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rQYSFVGWKERQKYPKSLASLLCLLDLVEAgqRDLGNGPITVHCMDGVTRSGLFCAIMSTIgklkseGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
 || .. |     .. |   | .|| . ..  .   .||. |||. || |.|...|.   .       ......||. .|..   .||...|. ....
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2392-2628 9.2e-29 95.0 In-house 56-282 (290) alignment 
Range on Protein: 2392-2628
Range on HMM: 56-282/290.0
NHHKNRYPDNIPLDKYRPYLMTGcseGQTNYVNATFLDGFNrrDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWP--AGDEALI
. .|||| | .  || |  |  |   .. .|| | ...| .   |.| || .|. || |.|||. . .  .|||| |.  . .  |.||.|  .|.   .
efkknrykdvvcndktrvilkdG...ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GPFVIDVSAEEREGDVIIrTFLLSNTNtVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVeagqRDLgNGPITVHCMDGVTRSGLFCAIMSTIGK
| . .  | |. . . ||   .||  . . .  . ... .  . | ..   ..|  .|| .|  .    | . .||..|||  |. |.| | ||  ..  
Geitvlcseeddkdanii.kktlsvrd.kdsGkehklkhlkikswpdks.valstlallrtlril....rka.sGpvvvhcsaGiGrtGtfvaievglqi

LKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
|    ..|.   |. ||..    |  . ||| . ... ..
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2096-2203 4.2e-27 89.8 In-house 41-160 (350) alignment 
Range on Protein: 2096-2203
Range on HMM: 41-160/350.0
VATRQENVSKNRYINIIPYDHSRVILDTDPDAP--------HEDYINASFVSGY-----LKPKA-YIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVE
..   |  .|||| ||.||.||||.|   . ..         .|||||....        .|.  |||||.||  || ||.... .  |.||..||..||
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

NKKRKCDPYWPEDieTYGDFTL
.  .||. ||.|   .| |.|.
lnlekcyrYWqeg..sydditv
subfamily_egg_pd Subfamily egg 2096-2331 6e-26 85.8 In-house 34-267 (307) alignment 
Range on Protein: 2096-2331
Range on HMM: 34-267/307.0
VATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENkkRKCDPYWPED-
 |  ..|  | |   .   | ||| |.       .|.| |  |.|      .| .| ||  || ||||||.||.|. |||||  .|.   .|. |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

---IET-YGDFTLTVVAE--RNYLNYTERTLTIrKAWDPEERRVQHFHYtSWPDMGLPLSatPlLEFITKVKEFearpSGPTIVHCSAGVGRTGTYFTID
   . |  | . .. .    .    ..   | .    | ||| ..|. .  .  ..   |  | |. . |...     | |..|..  || ...|  .|.
sdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnssdvys..p.lrvlrklrnl....skpvvvqdilGvskaatlvaie

SMMDMSAR--EQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
  .    |    .  ||  |  .| .|   |... .|.|.|  .|
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2385-2630 1.1e-24 82.1 In-house 34-278 (307) alignment 
Range on Protein: 2385-2630
Range on HMM: 34-278/307.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYWPA-
..   | | .|||| |    || |  . .  .   ..|. | .|    .   .|..| ||. |. .|| |. . . . ..|| . |.     | ||||. 
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

-GDEALIGPFVIDVSAEEREGDVII--R-TFLLSNTNTVATESSRVIRQYSFVGWKERQKYPKSLASllclLDLVEAGQRDlgNGPITVHCMDGVTRSGL
 |..   |     .| ..   . .        ... . . .. || |... .  | .|   .  |..    ..|.|| . |  . |. |||  || ||| 
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlta....inlleavryd..tnpvvvhcsaGvGrsGt

FCAIMSTIGKLKSEGN-IDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
  ||     |. .  |  |. . |..||.     . .| ||||.| |. ||. 
ivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0048076 (Phosphotyrosine protein) phosphatases II 2219-2331 1.9e-24 81.4 In-house 34-140 (145) alignment 
Range on Protein: 2219-2331
Range on HMM: 34-140/145.0
LTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPsGPTIVHCSAGVGRTGTYFTIDSMMDmsareQQINVLDFVYRMRTKRVKMVQ
|..    . .|| . ...|..|||.| | ..  ||||.  ..|. ... ||..||||||||||||.  .. |.      ..... . . ..|..| ..|.
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavp

TPEQYVFIYEALL
.|.|. |.||..|
npgqlrflyefel
0044763 (Phosphotyrosine protein) phosphatases II 2403-2628 2.5e-24 81.3 In-house 1-170 (178) alignment 
Range on Protein: 2403-2628
Range on HMM: 1-170/178.0
PLDKYRPYLMTGCSEGQTNYVNATFLDGFnrrdMYIATQMPlqhtvEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGDEaligpfvidvsaeere
||| .|  |..   .  . | ||.. ...    .|.... |     .|......... ..||.|.|  ..  . | .||| . .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

gdviirtfllsntntvatessrviRQYSFVGWKERQKYPkSLASLLCLLDLVEAGQRdLGNGPITVHCMDGVTRSGLFCAIMSTIGKlksegNIDVFHAV
                         || ....      . .|. .| .....|. .    .||. |||. || |||...|.   .       ......|.
........................iqylhipipDhgvpd.llehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

KKLRKCSGrMVPSEEQYLYIHDVVREY
. .|..   .||...|. ..... ...
elvrerRp.ivpnpgqlrqLyefelrl
0048179 (Phosphotyrosine protein) phosphatases II 2219-2328 2e-23 78.1 In-house 36-139 (144) alignment 
Range on Protein: 2219-2328
Range on HMM: 36-139/144.0
LTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPsGPTIVHCSAGVGRTGTYFTIDSMMdmsarEQQINVLDFVYRMRTKRVKMVQ
||    .. .|| . ......|||.| | ... ||||.  ..|. ... ||..||||||||||||. ... |.     ...... . ....|..|  .|.
lteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavp

TPEQYVFIYE
.|.|. |..|
npgqlrfLle
0051082 (Phosphotyrosine protein) phosphatases II 2420-2625 2.6e-23 77.7 In-house 3-149 (151) alignment 
Range on Protein: 2420-2625
Range on HMM: 3-149/151.0
TNYVNATFLDGFnrrdmYIATQMPLQhtveDFWRMIYDYNSNVIVMLNEINRNDqTCSQYWPAGDealigpfvidvsaeeregdviirtfllsntntvat
..| |.....|.     ......||.    ||........ ..||.|..   .. .| .|.|. .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

essRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAgqrdLGNGPITVHCMDGVTRSGLFCAIMSTIgkLKsegnIDVFHAVKKLRKCSGRMVPSEEQYL
   . .... ...|..  . | |....| .|.|...     .|||. |||. |. |.|...|..  .  |.    .... |.. .|.. . .| ...|.|
...ievlhipildwpdp.glplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqfl

YIHDVV
... ..
fqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2392-2619 3.3e-23 76.9 In-house 50-271 (301) alignment 
Range on Protein: 2392-2619
Range on HMM: 50-271/301.0
NHHKNRYPdNIPLDKYRpyLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EINRNDQTCSQYWPA--GDEALI
...|.||| ..| .      .   ..|.   . | ...   . . .|||| ||. | |||| |.  |. . ||||  ..... . |..| |   ...  |
pkdkhryp.tvPckPst..avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GPFVIDVSAEER--EGDVIIRTFLLSntNTVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRdlgngPITVHCMDGVTRSGLFCAIMSTI
| | | .  .|   . ... ||. .   ..    ..| .  | .. | .|.  ||| | |  |..||   ..     || ||| .|. ||  | .     
grfkikiknkelilnkkiskrtleve..dstgkfatrtvthyqysewtdrg.vPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteyla

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYL
 ..... .|.. .|.|.||.   . |  ..|  
reveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2372-2634 4.5e-23 76.4 In-house 28-292 (305) alignment 
Range on Protein: 2372-2634
Range on HMM: 28-292/305.0
LDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCsegQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EIN
. ||  |     |.| | .....|||| |   ||. |  | .       .|. | ..        .| || ||..|  ||| | .. . . | ||   ..
fvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnlle

RNDQTCSQYWPAGDEALIG----PFVIDVSAEEREGDVIIRTFLLSNTNTV-----ATESSRVIRQYSFVGWKERQKyPKSLASllcLLDLVEAGQrdLG
.  . |..|... |.  .        | |  |  .   . .      |.||     . |..| . .| .. | .|   | .  .   .|.|.|  .    
kgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv.paadla...ilellekar..ps

NGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVF-HAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEI
 |||.|||  |. |.|    .   . .| .   |.   . ..|.|.     . ...|||..|.|. .|.   ..
kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2418-2631 8.5e-23 75.8 In-house 65-273 (288) alignment 
Range on Protein: 2418-2631
Range on HMM: 65-273/288.0
GQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLSNT
    |..|  .   . .   | .| ||. |.| .|.|. . . . ||||.|. ..  .   .|.|   |..| || .  .|  .  . | ...  || ..
dpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllris

NTVATESsrVIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQRdlgngPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPS
... ..   ....  .  |.. .  |..  | | ||. ... |.     || ||.  || |.| .  |.  .  |... .. . . ..|||.   . . .
kegeekv..ivkilhlleWdd.dgvPenylsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqt

EEQYLYIHDVVREYLAS
| ||||.| .| |.|. 
emqylyvhrcvleelll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2384-2629 1.5e-22 74.6 In-house 46-289 (305) alignment 
Range on Protein: 2384-2629
Range on HMM: 46-289/305.0
MQAGKSSE-NHHKNRYPDnIPLDKYRPYLMTGCSegQTNYVNATFLDGFN-RRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EINRNDQTCSQYW
..| .|.. .  |||| | .| .     ..   |   ..|. | ..         .|..| ||..|...|| |. . . . ||||   ..     |.|||
fnanqsadiaitknryqd.vpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PAGD--E-ALI-GPFVIDVSAE-EREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWKERQKYPKSLASLlCLLDLVEAGQrdlgnGPITVHCMDGVTR
||       |  |  | .||     | |  |.  ||  |   . . .  .|.  .  | .|   |  |.||  ||  .   .      || |||  |. |
paaqgeklelksgivvenvsgskpmerdaeiqitllnlt..ysgdqkmsvrhlqwtewpdrgvppckltsl.ellsairgsk.....vpivvhcsagigr

SGLFCAIMSTIGKLKSEGNID-VFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
.|   ||   . |.  . .   . . || ||      . .. |||.|| |. .|.
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2115-2331 1.6e-22 75.0 In-house 31-256 (290) alignment 
Range on Protein: 2115-2331
Range on HMM: 31-256/290.0
DHSRVILDTDPDAPHEDYINASFVSgYLKPKAYIATQGPLST-------TVFDFWRMVWQERVPVIVMLTKLVENKKR----KCDPYWPEDIE---TYGD
 ..||.|        .||| |..|. . .  . |.|| |.         |...|| |. ||.|  .||| .  |...      |  | || ..   ....
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

FTLTVVAERNYLNYTERTLTIRkAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMMDMSA-REQQ
.|.      .  .  .|.|...   | ||  |.|  . .| ..  . .   ||. | |||  ..    | ||||  |. |  .  .|.  . . |  ...
ltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiilgyQkiaetsgs

INVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
... | .. .| .| ......... |.  ...
vkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2153-2327 3.2e-22 73.4 In-house 99-281 (302) alignment 
Range on Protein: 2153-2327
Range on HMM: 99-281/302.0
PLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE---TYGDFTLTVV-AERNYLNYTERT------L--TIRKAWDPEERRVQHFHYTSW
|   |.  .| .. | .| ..| |...||....|| .|. ....   ..| .|.. |  . .  ..|..       .  .  |  .  .. |. .....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDMGLPLSATPLLEFITKVKEFEARpsgpTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIY
|| | |  | . |. .   . .        .||||||||||||  .|   ... ....  ..|. |  .|. |   ||. .| ... 
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2381-2625 1e-21 71.8 In-house 41-286 (310) alignment 
Range on Protein: 2381-2625
Range on HMM: 41-286/310.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEgQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQY
| |.      .. ||||| | . ||. |  |    |    .|. | ..     |. .| .| |||||. ||||||..  .. |..|  . .. .  |  |
dssltyeaykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPA-GDEALIGPF-V--IDVSAEEREGDVIIRTFLLSNTNTVATESSRVIRQYSFVGWKERQKypKSLASLLCLlDLVEAGQRDLGNGPITVHCMDGVTR
||. |     |   |  .  |.|| |   .  ||.  |       .     . |.. | .     . .    |   . .    ..  ||  |||  |. |
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd..rgvpdekch.tvpqrllaqvrhgpcvvhcsagkdr

SGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 .. .|.  .| ||.   ..|. . . .|.|     . .| |||.|. | 
lyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2145-2328 1.2e-21 71.8 In-house 5-198 (199) alignment 
Range on Protein: 2145-2328
Range on HMM: 5-198/199.0
KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE---TYGDFTLTVVAERNYLNY--TERTLTIRKAWDPEERRVQHFHYTS
. ||||| ||  |. |||.|||.     |||.     ||.     |||        || ...|. .     .|  |   ||   .  |  | . |. .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGLPLSATpLLEFITK----VKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMdMSAREQQINVLD---FVYRMRTKRVKMVQTPEQYVFIYE
| .   |  |  .. |.       | .|     | ||||| | | || . ..|  .  |  | .  |.|      |.|  |. .. . ..| |||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2145-2328 1.2e-21 71.8 In-house 4-197 (198) alignment 
Range on Protein: 2145-2328
Range on HMM: 4-197/198.0
KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE---TYGDFTLTVVAERNYLNY--TERTLTIRKAWDPEERRVQHFHYTS
. ||||| ||  |. |||.|||.     |||.     ||.     |||        || ...|. .     .|  |   ||   .  |  | . |. .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGLPLSATpLLEFITK----VKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMdMSAREQQINVLD---FVYRMRTKRVKMVQTPEQYVFIYE
| .   |  |  .. |.       | .|     | ||||| | | || . ..|  .  |  | .  |.|      |.|  |. .. . ..| |||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
PTPc_DSPc_SM00012 2525-2626 1.8e-21 71.7 In-house 2-104 (105) alignment 
Range on Protein: 2525-2626
Range on HMM: 2-104/105.0
IRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLG-NGPITVHCMDGVTRSGLFCAIMSTIGKLKSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIH
...| . ||..  . |..  |.| ||. |.  ... . ..|. ||| .|| |.| |.|.   . .|..| ...|.|  ||.|||   .|| .|||||...
vkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DVVR
... 
rall
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2435-2623 2.5e-21 70.8 In-house 5-198 (199) alignment 
Range on Protein: 2435-2623
Range on HMM: 5-198/199.0
DMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEA--LIGPFVIDVSAEEREGDVIIRTFLLSNtNTVATESSRVIRQYSFV
  ||||| ||..|. |||.|...  |  |||.|. ..| .   . |||. . .    | . . . .   . |  | ...|.| || |  |.| | .| | 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.nttappstreishyqft

GWKERQKYPKSLAS-LLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKL-KSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
 |||.     .|   ..     |     .  . |. ||| ||   .|.| |.   .    .|    .|.|   |.||..   .. | ..| .|..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2436-2623 2.6e-21 70.7 In-house 5-197 (198) alignment 
Range on Protein: 2436-2623
Range on HMM: 5-197/198.0
MYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEA--LIGPFVIDVSAEEREGDVIIRTFLLSNtNTVATESSRVIRQYSFVG
 ||||| ||..|. |||.|...  |  |||.|. ..| .   . |||. . .    | . . . .   . |  | ...|.| || |  |.| | .| |  
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.nttappstreishyqfts

WKERQKYPKSLAS-LLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKL-KSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
|||.     .|   ..     |     .  . |. ||| ||   .|.| |.   .    .|    .|.|   |.||..   .. | ..| .|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_eak_pd Subfamily eak 2091-2248 9.2e-21 68.6 In-house 41-197 (332) alignment 
Range on Protein: 2091-2248
Range on HMM: 41-197/332.0
MYTWEVATRQENVSKNrYINIIPYDHSRVILdTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
. . ....| |.| .|  ..|.|||.  | | |     .. ||||| .      . || |  .  . || ||.|| ... | ||.| . ||.|  | | |
llsisetarleavnrn.vvkivpydrylvrl.tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPEDI---ETYGDFTLTVVAERNYLNYTERTLTIRKAwdPEERRVQHFHYTSWPDMGLPLS
.|..      .| . ..     .  ..  | | ..|    |  ||.|...  | .. ||  
fpdktreelkfGildverkefvkrniletrllelskG..nethrvlhykvfGwtettlpky
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2384-2484 1.5e-20 68.0 In-house 37-146 (392) alignment 
Range on Protein: 2384-2484
Range on HMM: 37-146/392.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-----DQTCSQ
 ....   | .|||| ...|.|. |  |       ...|.||.....|.    |||.|.|   ...|||||... |   |.|.....       ..|..|
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaq

Y----WPAGD
.    ||  |
fhftewPdkd
subfamily_ptpA1_pd Subfamily ptpA1 2386-2589 2.4e-20 67.7 In-house 41-256 (418) alignment 
Range on Protein: 2386-2589
Range on HMM: 41-256/418.0
AGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRdMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPA--
 |    |  |||| . .|... |  |     .  ..|.|| ..||   .  .|.|| ||  |. |||||...    .||||.  . |    | .|||   
egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

GDEA-LI---GPFVIDVSAEEReGDVI---IRTFLLSNTNTVATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDL-----GNGPITVHCM
| |   |   |  |.   . |   .||    |  .  |        .| | || . || .. . |     .  ||  .   | ..      | || ||| 
ggeqfsiygngnevfgtysvel.veviqdpereiitrnirltfegetrditqyqyegwpdh.nipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

DGVTRSGLFCAIMSTIGKL
 || |.| ||. .  . ||
agvgrtgtfctavimmkkl
subfamily_CG42327_pd Subfamily CG42327 2393-2550 4.4e-20 66.6 In-house 29-187 (319) alignment 
Range on Protein: 2393-2550
Range on HMM: 29-187/319.0
HHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAG----DEA
. |.|. . .|| . |. |    .. ...|..|... |..  .  |||.|..|. .  ||||.... .| ||| | ..  .  . |..|.|.     .. 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

LIGPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFvGWKERqKYPKSLASLLCLL
| | . . .   | .   .| |.|| .   |  | || .  | .  | |  . | . |.|...|
lyGdilvtlkgrevkdryaistlllkr...vdkeesrelthywy.kwlea.evPaeeaaliaml
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2098-2331 1.3e-19 64.7 In-house 47-282 (302) alignment 
Range on Protein: 2098-2331
Range on HMM: 47-282/302.0
TRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVSGY-LKpKAYIATQGPLSTTV---FDFWRMVWQERVPVIVMLTKLVENKKrKCDPYWPE
. ..|..||.  ..  .|. .|.|.. ||    .|.||| |.   |. .  | .| | ....    .|||||.||..  .|.| .  | ||   . ..|.
afkknlkknqsedvpildsnlvkleaepd....syvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpk

DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEER----RVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDS
  ..| ..    |  |   .  | .        ||.      ..  . | |..   | . . | . ..|| . ..  . .|..    |.|| |. .|   
ksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

MMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
 ..   .... |. . |  .|..| ..|.. .|||..| |||
aveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2428-2512 2.5e-19 63.9 In-house 229-312 (440) alignment 
Range on Protein: 2428-2512
Range on HMM: 229-312/440.0
LDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEInrNDQTCSQYWPAGDEA-LIGPFVIDVSAEEREGDVIIRTFLLS
..|. ... .|||||||. || ||||...||.   |.|||..  ||.||| |||    .  .||| .     |    | .||. | 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2142-2362 3e-19 64.1 In-house 25-243 (255) alignment 
Range on Protein: 2142-2362
Range on HMM: 25-243/255.0
LKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFT-LTVVAERNYLNYTERTLTIRKAWD--PEERRVQHFHYT
.||.     .   | ||  |.... | .  |.|||. . |... ||. |.| . .    .. ..|.. ..  .   |||.|        . . |.|..|.
vkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysyk

SWPDMGLPLSATPLLEFItKVkefeARPSGPTIVHCSAGVGRTGTYFTIDSMMD---MS---AREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
 |..   |  |  .|. . ||    .| | . .||||.|.||. ..  ....     .|   .   ... | ..  .| || . ..|| |  |    .|.
GWieknaPelareilnil.kv....vrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

CLlcgytsVPTKTIVQYFTRLEQTNLHTKR
 .       | . . . .... .. ||...
lv......fpkgeleakyqeirksylharq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2390-2628 3.8e-19 63.4 In-house 35-268 (281) alignment 
Range on Protein: 2390-2628
Range on HMM: 35-268/281.0
SENHHKNRYPDNIPLDKYRPYLMT-GCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPAGDEAL
  | .|||| .   ||  |  |      .  |.|. | ..     .  || || | . |  ||||||.. |.  |||| .. . | . |..|.|    . 
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

IGPFVIDVSAEereGDVIIRTFLLSNTNTVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAgqRdlgNGPITVHCMDGVTRSGLFCAIMSTIG
.    . || |      . .... .  |      .|.| .. .  | . |  |.|   .| .|  . |  |     |  .||  || ||| . |.  .. 
lqfdklsvsye...dstvnkslvttrlnlsyegetrlithwlwkewpdwq.vpessevmlkilrkira..r...stppvihcsagvgrsgtlmaveialq

KLKSEGNI-DVFHAVKKLRkCSGRM--VPSEEQYLYIHDVVREY
 ..|   . |. . | .||  .||   | . .||. |  |. ..
sihshftlpdikqivshlr.vtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2394-2632 6.7e-19 62.9 In-house 37-273 (285) alignment 
Range on Protein: 2394-2632
Range on HMM: 37-273/285.0
HKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFLDGFN-RRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN-RNDQTCSQYWPA--GDEALIG
  ||| |   ... |  |     . . .|. |...      .  ||.|| ||  |. |||.|||. .   ..||  .     . |. |.|   |.   .|
dlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

PFVIDVSaeEREGDVIIRTFL--LSNTNTVATESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEAGqrDLGNGPITVHCMDGVTRSGLFCAIMSTIG
 . | ..  | . . |  | |  |. .||  . |  .  ..  | |   |  |.    .. |   |.    .  . || |||  || |.  |  |  .  
kyeitlt..eckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidyati

KLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASC
..  . ||...  |...|    . | |  |.|... |. ||.   
rimenpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2101-2335 1.1e-18 61.9 In-house 46-280 (303) alignment 
Range on Protein: 2101-2335
Range on HMM: 46-280/303.0
ENVSKNRYINIIPYDHSRVILDtDpdaphEDYINASFVSGYLKPKAyIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE--DIETY
.|. |||....|  |||.| |  |       || ||..    . || | || ||| |  |||.|. ...| ....|    | .|   |  .|.  |.  .
knmdknrfvdvicldhskvkls.d.....ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQH-FHYTSWPDMGLPLSATP-LLEFITKVKEFE--ARPSGPTIVHCSAGVGRTGTYFTIDS-MMDM
 . .. |   ..       .| .    . . .   |  || .||   .|  ..| ..  | ... .     .| ||.    .|.||.||.  ...  . .
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
 . .  ....  .  .|  |.. ||   |. ..|  | | .|
hseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2098-2194 4.1e-18 59.8 In-house 44-156 (349) alignment 
Range on Protein: 2098-2194
Range on HMM: 44-156/349.0
TRQENVSKNRYINIIPYDHSRVILDTDPDAPH--------------EDYINASFVSG--YLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVE
   |  .|||| .|.||.||||.|   . ...              .||||| ...   .   | ||||| || .|| ||....  ..|.... |..  |
eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

NKKRKCDPYWPED
.  .||| || | 
lslekcdiywqel
subfamily_egg_pd Subfamily egg 2382-2627 4.5e-18 60.0 In-house 30-268 (307) alignment 
Range on Protein: 2382-2627
Range on HMM: 30-268/307.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEInRNDQTCSQYWP
.|..   |..| .| | .     |  |  |         ... |  ..|    . .| .| ||. ||.|||||..  . . ||||.   .. . |  |||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr.keserceyywp

AG--DEALI--GPFVIDVSAEEREGDVIIRTFLLSNtntVATEssrviRQYSFV-GWKERQKYPKSLASLLCLLDLVeagqRDLGNgPITVHCMDGVTRS
    | . .  | . |.    ... | . |   |     | ..     ..  |.  |.   ..   . | | .| ..    |.| . |. |....||...
kaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgd.....deerflehwqgdvnnssdvysplrvlrkl....rnlsk.pvvvqdilGvska

GLFCAIMSTIGKLKSE--GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
. . ||  .. .|         | .||. ||.     | |  .||... .|  
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2518-2635 5e-18 59.7 In-house 273-390 (392) alignment 
Range on Protein: 2518-2635
Range on HMM: 273-390/392.0
ATESSRVIRQYSFVGWKERQKYPK-SLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEE
.. .|  . || | ||       .    ||| |.  | .   .  .  | |||. |  |.|.||. |  | ..     .|.| .|| ||    ..| .||
slkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqtee

QYLYIHDVVREYLAScEIY
.| ...||.|||| . | |
eyafvydvireylht.eky
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2388-2625 5.5e-18 59.9 In-house 29-291 (297) alignment 
Range on Protein: 2388-2625
Range on HMM: 29-291/297.0
KSSENHHKNRYPDNIPLDKYRPYLMTGCSEgqTNYVNATFLDGFNRR--DMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGD
| .   .|||| | .  |. |  |. . .|  ..|.|| ..   .      || .| ||. ||.|||..... . .||||. ... .  . |  |||  .
krnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

E--ALIGPFVIDV-SAEEREgdviIRTFLLSNTNTVATESSRVIRQYSFVGWKERQkYP---KS--------------LASLLCLLD--------LVEAG
.     | .|..  |    |      .  |.. . .  . |||.|   |..| .    |   .               .  .|.|..         .|. 
qerlkagdvvveflsstsde....fdrviltelqliyrsesrvvrhvqflswpdhG.vpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

QRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
. .   | .. |||  || |||.    .  . ||. .   ||   ...||.   |.| . ||. ...|.|
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2223-2331 1.6e-17 58.3 In-house 210-341 (350) alignment 
Range on Protein: 2223-2331
Range on HMM: 210-341/350.0
KAWDPEErrVQHFHYTSWPDMGL---PLSATPLLE----FIT---KVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMD----MSA---REQQINV---
 | || .  | ....  |.|..|   | |  . ||    .|      . ..   | | .||||||||||||. |.||..     ..    . ....|   
aasdPyv..vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak

-----LDFVYRMRTKRVKMVQTPEQYVFIYEALL
        | ..| .|..|||. .|..|||||||
trDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2517-2631 1.9e-16 54.4 In-house 83-196 (440) alignment 
Range on Protein: 2517-2631
Range on HMM: 83-196/440.0
VATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEE
..   ||...|| . || ..   ||  . .| ... |.  |   ||||. |||  |. |.|.  |. | . . |   .||.|  .. .|.   .|| . |
ingiesrtlkqyhyqgwpdk.gvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYLYIHDVVREYLAS
|| ..|..| | | .
qyafvheavlegllc
subfamily_hpo-7_pd Subfamily hpo-7 2154-2337 3.6e-16 53.9 In-house 43-230 (263) alignment 
Range on Protein: 2154-2337
Range on HMM: 43-230/263.0
LSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFT-LTVVAERNYLNYTERTLTIRKAWD--PEERRVQHFHYTSWPDMGLPLSAT
|  |.  |.... | .  |.|||.   |. . ||. |.| . .    .. ..|.. .   .   .|| . .  .   . . |.|. |. |..   |  | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLLEFITkVkefeARPSGPTIVHCSAGVGRTGTYFTIDSMMD---MS---AREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCG
  |. .  |    || | . .||||.|.||.  .  ....     .|   .   ... | ..  .| .| . ..|| |  |    .|. .|  
eilnilk.v....arnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2567-2629 6.8e-16 52.4 In-house 2-64 (69) alignment 
Range on Protein: 2567-2629
Range on HMM: 2-64/69.0
VHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|||  |  |.| | |||  . ..|||  .|.|  |. .|||   ||  |..|..||| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2566-2629 7.1e-16 52.4 In-house 2-65 (69) alignment 
Range on Protein: 2566-2629
Range on HMM: 2-65/69.0
TVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 |||  |  |.| | |||  . ..|||  .|.|  |. .|||   ||  | .|..||| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2439-2626 3.3e-15 51.0 In-house 64-256 (290) alignment 
Range on Protein: 2439-2626
Range on HMM: 64-256/290.0
ATQMPLQ-------HTVEDFWRMIYDYNSNVIVMLNEINRNDQT-----CSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRV
.|| |..        |.|.|| |. . ... .||| | . ...      |..| |   |.|  .. . .     | | ||..|. ..   .    |    
ltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd....eeeft

IRQYSFVGWKERQkYPKSLASLLCLLDLVEAGqrdlgNGPITVHCMDGVTRSGLFCAIMSTIGKLK-SEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
.  . ..||....  ...  .|| |.. |.|      . |. |||.||. ||  . ||     |.  ..|.. .  ..|.|||    .. |.... ..  
vtHsllkgWnkln.vqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

VVR
.. 
giv
0048076 (Phosphotyrosine protein) phosphatases II 2519-2628 3.5e-15 51.4 In-house 41-142 (145) alignment 
Range on Protein: 2519-2628
Range on HMM: 41-142/145.0
TESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDlgNGPITVHCMDGVTRSGLFCAIMstI--GklkseGNIDVFHAVKKLRKCSGRMVPSEE
.  .| . || ...|  .   | .|. || .|...|. ...  .||. |||. || |.|...|..  .         ......|....|..   .||...
ellerlgiqylylpwpDh.gvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaay..lmll.....lgvsleealelvrsqrpgavpnpg

QYLYIHDVVREY
|. .......|.
qlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 2522-2623 7.5e-15 50.4 In-house 46-139 (144) alignment 
Range on Protein: 2522-2623
Range on HMM: 46-139/144.0
SRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRdlGNGPITVHCMDGVTRSGLFCAIMSTIgklksEGNIDVFHAVKKLRKCSGRMVPSEEQYLYI
 | . || ...|  ..  | .|. || .|...|. ..   .||. |||. || |.|...|.   .     . ......|.. .|..   .||...|. ..
eregiqylhlpwpDhg.vpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

HD
..
le
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2066-2152 7.8e-15 48.8 In-house 12-95 (95) alignment 
Range on Protein: 2066-2152
Range on HMM: 12-95/95.0
GYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDApheDYINASFVSGYLKPKAYIATQG
 .| |  .| .  |  ..  ..     .. | . . |. |||..||.||| .||.| |  |.   ||||| || || . ..|||.||
shvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrds...dyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2390-2484 3.1e-14 47.5 In-house 45-154 (350) alignment 
Range on Protein: 2390-2484
Range on HMM: 45-154/350.0
SENHHKNRYPDNIPLDKYRPYLMTG--------CSEGQTNYVNATFLDGF-----NRRDM-YIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQ
 |   |||| . .| .. |  |  .         |    .|.|| .|           |  ||||| ||. ||.||...|.  . .||..|.. .. | .
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

TCSQYWPAGD
 | .||. |.
kcyrYWqegs
fn3 Fibronectin type III domain 1681-1770 3.2e-14 46.0 Pfam-A 2-82 (85) alignment 
Range on Protein: 1681-1770
Range on HMM: 2-82/85.0
PVTELQVLNRTLDSIELRWEAPKSLNGELLGYTISYVPVVKNEpkdgnlstkrPVMNIHNTRST-HILVSELDPATEYIFRISANNRVGDG
... |.| ..| .|..|.|..||. .|.. ||.. | .. ..|          .  .....|.| .  ...| | ||| ||. | |..| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2101-2199 9.6e-14 45.6 In-house 33-129 (332) alignment 
Range on Protein: 2101-2199
Range on HMM: 33-129/332.0
ENVSKNRYINIIPYDHSRVILdtDPDAPHEDYINASFVSGYLKPKAYIATQGPLS-TTVFDFWRMVWQERVPVIVMLTKLVENKKRKCdPYWPEDIETYG
.|.  ||   .  .||||| |   |.  ..|. |||.| || |  ||| .| |.   | . ||||| . .  .|...  . |..|||. ||   |     
nnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka.pydisdrgfek
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2384-2483 9.7e-14 45.6 In-house 88-181 (244) alignment 
Range on Protein: 2384-2483
Range on HMM: 88-181/244.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGcSEGQTnYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDqtcsQYWPAG
|.   . .| .|||    .|.|  |  |  | | |.| |.||.|.  . |   || || ||  |  |||.|. .   ||.|.|  .. .|    .|||  
mkdafnpnnswknregaglpfdfnrvplskg.smgnt.yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpds
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2395-2636 3e-13 44.1 In-house 46-283 (312) alignment 
Range on Protein: 2395-2636
Range on HMM: 46-283/312.0
KNRYPDNIPLDKYRpYLMTGcseGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWP-------AGDEA
 ||||.    |. | . ..|    .  |. | |.    . . ...|| ||. |.  ||..     |  |..|  . .   . |..|           |  
lnrypniqcwdrgr.ftlag...denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

LIGPFVIDVSAEEREGDVIIRTFLLSNTNTVATESsrVIRQYSFVGWKERqKYPKSLASLLCLLDLVEagqRDlgNGPITVHCMDGVTRSGLFCAIMSTI
.   .. ..    .  | |    |    ..   ||   . .| .  | .    | |  . | ||  |    .|  . |.  ||  || |.| .. | | |
vyteycteieiggkskdkithrvlkvvvkatgqes..klnhyqwaswpdh.gmpdscdtalrllsavk...kd..kkpviahcsagvgrtgtlaliesmi

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYE
  |.   . .| ..   |||   | |    ||.|   .| |.| |  .|.
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2437-2585 3.9e-13 44.1 In-house 37-171 (255) alignment 
Range on Protein: 2437-2585
Range on HMM: 37-171/255.0
YIAtqmplqhTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVaTESSRVIRQYSFVGWKE
|.        ||. |...|   ...|.||| . .  . . ||.|.|   .       ..|.. .   ||..||  .  | .      . .. ||. || |
ysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWie

RqKYPKSLASLLCLLDLVEAGqRdlgngPITVHCMDGVTRSGLFCAIMST
. . |.    .| .| .|    .     .. |||  |. ||  |  . . 
k.naPelareilnilkvvrds.k.....svvvhCstGiGrsaafvlaelv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2131-2244 6.5e-13 42.9 In-house 123-234 (244) alignment 
Range on Protein: 2131-2244
Range on HMM: 123-234/244.0
DYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENkkrkcDPYWP--EDIETYG-DFTLTVVAERNYLNYTERTLTIRKAWDP
 |||||||    .   || || ||. | .|||.|. .  | |.|.|  . |.     | |||  | .| |  | |.|.    .. |     | |    . 
tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmne

EERRVQHFHYTSWPDMG
  . .  |  . ||  |
shqaltmfqisnwpsdg
fn3 Fibronectin type III domain 1579-1667 7.5e-13 41.6 Pfam-A 1-85 (85) alignment 
Range on Protein: 1579-1667
Range on HMM: 1-85/85.0
PKPTGLEVLEIGETNVTLQWVRPNPPHGIIHEYKLQFWRQSEMRsnQSIEITiRSEDEKvNGTLIGLNPFTAYVIKIRGVTSAGPGDWS
..|..| | |...|..||.|  |....| |  |..... .....  .. |.| ...... . || ||.| | |..... |. || | .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeft.vprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2139-2221 7.6e-13 42.6 In-house 230-311 (440) alignment 
Range on Protein: 2139-2221
Range on HMM: 230-311/440.0
SGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLveNKkRKCDPYWPEDIE--TYGDFTLTVVAERNYLNYTERTLTI
 || | .|.|||| || .||.||||.| . |.  |.|| .|  |  . |  ||| .    |.| ||.      |      ||| .
egyskknafiatqmpldstvldfwrlvhdyristiimlnql..nd.ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_CG42327_pd Subfamily CG42327 2267-2331 1.1e-12 42.3 In-house 247-312 (319) alignment 
Range on Protein: 2267-2331
Range on HMM: 247-312/319.0
SGPTIVHCSAGVGRTGTYFTIDSMMDM-SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
 || .|||| ||||||.  . |  .      .. ... . |. .|  | . |.| ||| |||  | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2271-2336 4.4e-12 40.2 In-house 2-67 (69) alignment 
Range on Protein: 2271-2336
Range on HMM: 2-67/69.0
IVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
.||||.| |||||. .|   |     |. ..... |  ||  |  ||    .|.||..|| | |  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_hpo-7_pd Subfamily hpo-7 2433-2584 5.7e-12 40.1 In-house 36-176 (263) alignment 
Range on Protein: 2433-2584
Range on HMM: 36-176/263.0
RRDMYIAtqmpLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVaTESSRVIRQYSFV
|...|.     |  |.. |...|   ...|.||| . | .  . ||.|.|   .       ..|.. .   ||...|  | .|        . ...||..
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.Kkkthtvkhysyk

GWKERQkYPKSLASLLCLLDLVEAGqRdlgngPITVHCMDGVTRSGLFCAIMS
|| |..  |.   . | .|...    .     .. |||  |. ||  |  . .
gWiekn.dpelareilnilkvarns.k.....slvvhcstGiGrsaafsvaEl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2112-2244 9e-12 39.4 In-house 3-125 (130) alignment 
Range on Protein: 2112-2244
Range on HMM: 3-125/130.0
IPYDHSRVIldtdpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENkkrkcDPYWPE--DIETYG-DFTLTVVAE
.... ||.          ..|||||||    . . |. || ||. |  |||.|. .  | |.|.|  . |.     | |||.   .| |  | ..|.   
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

RNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMG
 .. |     | | .      . .  |. . ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg
fn3 Fibronectin type III domain 1387-1469 9.9e-12 38.0 Pfam-A 9-84 (85) alignment 
Range on Protein: 1387-1469
Range on HMM: 9-84/85.0
TSDNPTSIRLNWNAPPNQKCPINSYVVSYRLVRQDRclldddwPTHELAVVANHGDVEIDSLIPFSTYELKVFAVTEAGNGSM
.. ..||..|.|..|.... || .| | || ... .       ...|  | ...  |..  | | ..||..| ||..||.|  
sevtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2271-2337 1.3e-11 38.7 In-house 1-67 (69) alignment 
Range on Protein: 2271-2337
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCG
.||||.| |||||. .|   |     |. ..... |  ||  |  ||   ..|.||..|| | |  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2062-2140 1.9e-11 38.0 In-house 9-85 (440) alignment 
Range on Protein: 2062-2140
Range on HMM: 9-85/440.0
VELSGYVKEKTAngEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSG
.... ||...       |. ..  || | .   ..|.  .|  |||| ||. ||||||.|.     |..||||||...|
adfadyvqnnrr..srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
fn3 Fibronectin type III domain 669-751 2.1e-11 37.0 Pfam-A 1-85 (85) alignment 
Range on Protein: 669-751
Range on HMM: 1-85/85.0
SAPSAVEVIDLSTDSVTLSWGEVPcgHRKGLISNYLLMLRGAQQG----TQIVSASQHSYTFPDLAECFMYNFTVAAHNMAGVGPTS
|||. . |.. ...|.|||| . .  ...| |..| . .| ...|    .. |.....|.|...| .   |.|.|.|.| || ||.|
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1484-1566 2.2e-11 36.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 1484-1566
Range on HMM: 2-85/85.0
APDAITVDLVTSREIEFSWREPPcgTRHGDIVHYEYQLLDA--KN-DRTLMATTTETVVQIGFLTPYTEYRFSVRAASLKGYGPFS
||  ..|. |||.....|| .|.  ...|.|..|| .. ..   . ...  .. |.| |..  |.|.|||.|.|.| . .|.||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 766-853 3.5e-11 36.3 Pfam-A 2-84 (85) alignment 
Range on Protein: 766-853
Range on HMM: 2-84/85.0
PVPNLRVTS-TPTEIHLSWDPP-VQSACQMEYIVRYTPQVLDQciaqltegPIVAGNTNL-TTDFTIAGLVPYSTYSVEVLARNSIGFGVP
.. ||.|.. |.|...|||.||  ...    | |.| ..   .        . .  ..   || .|. || |...|...| |.|  | | .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2262-2332 8.7e-11 35.7 In-house 260-342 (349) alignment 
Range on Protein: 2262-2332
Range on HMM: 260-342/349.0
FEARPSGPTIVHCSAGVGRTGTYFTIDSMMD-MSAREQQINVLDF-----------VYRMRTKRVKMVQTPEQYVFIYEALLE
...  . . .|||||| ||||.. |.|.... ..  ... | ...           |  .| .|. |||   |...||||||.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
fn3 Fibronectin type III domain 1169-1255 1.4e-10 34.3 Pfam-A 2-79 (85) alignment 
Range on Protein: 1169-1255
Range on HMM: 2-79/85.0
PVTSLNLQTLSSAEMNITWSPPAAQPCPIVSYGLRYLPTNTDQcdatirrltATRTSDVETQNTSAVVSGLLPFTTYRVMVWARTDA
... |..   .| .....||||. .  ||..| ..| .... .         .... .|. . ||....|| | |.|.. | |...|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1288-1364 1.6e-10 34.1 Pfam-A 12-85 (85) alignment 
Range on Protein: 1288-1364
Range on HMM: 12-85/85.0
KPTKLNVSWEEVPcgHRCGDITFYAYELEALEDSAlNSKTSKIPASHRYVTLDDLEPCEVYQFRVRARTRKGWGPFS
 .|.|..||.. .  .. |.|| |  |..  ...   .|. ..|.... ||| .|.|   |.|||.|....|.||.|
tstsltlsWsppk..dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2100-2176 2.9e-10 34.2 In-house 35-116 (347) alignment 
Range on Protein: 2100-2176
Range on HMM: 35-116/347.0
QENVSKNRYINIIPYDHSRVILDT-----DPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVML
. ..||||  .    | .||.|        .  . | ||||| .      | || || ||  || |||.||   .|  .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_CG42327_pd Subfamily CG42327 2561-2630 5.3e-10 33.4 In-house 246-316 (319) alignment 
Range on Protein: 2561-2630
Range on HMM: 246-316/319.0
GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 .||..||| ||| |.||  |   .| .|.     .|. . |  .|.  .. | . ||| .|. |. || .
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
fn3 Fibronectin type III domain 868-950 5.9e-10 32.3 Pfam-A 3-83 (85) alignment 
Range on Protein: 868-950
Range on HMM: 3-83/85.0
VTQLTLVETTEDSISLTWDLPCgQTHGGILLFHYELSNENVPIaALTEGDSPRNATSLTINNLASCTPYEFRIKAKTSAGYGR
...|.. |.|..|..|.|. |  . .| |  .  |..... .  . .| . ||..||.|...|   |.||||..| . ||.|.
PenlsvsevtstsltlsWsppk.dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_eak_pd Subfamily eak 2382-2537 1.7e-09 31.6 In-house 42-193 (332) alignment 
Range on Protein: 2382-2537
Range on HMM: 42-193/332.0
VSMQAGKSSENHHKNrYPDNIPLDKYRPYLmTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYW
 |.. ..  |. ..|   . .| |.|   | | .   .  |.||. ..  .    || | .. .  |  ||.|... .|  ||.| .... . .   .|.
lsisetarleavnrn.vvkivpydrylvrl.tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PAG--DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRViRQYSFVGWKERQ
|    .|   | . ..     ... .  | . ||  |    |. ||   | . || | .
pdktreelkfGildverkefvkrniletrllelskGn....ethrv.lhykvfGwtett
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2388-2466 2.2e-09 31.3 In-house 43-114 (303) alignment 
Range on Protein: 2388-2466
Range on HMM: 43-114/303.0
KSSENHHKNRYPDNIPLDKYRPYLMtgcsegQTNYVNATFLDgFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML
.  .| .|||. | | ||. .  |       .. |. |..|. .. .   | ||.||.||  |||.|| . . .....|
qfvknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll
fn3 Fibronectin type III domain 981-1054 2.3e-09 30.5 Pfam-A 15-80 (85) alignment 
Range on Protein: 981-1054
Range on HMM: 15-80/85.0
EADVTWSPPEVNGCPILYYRVTYVLTNLGMcgpissSLRMFRfAGNTSHwFIRLSNLEPYSTYDVYVQAVSDAG
.. ..||||. .| || .|.|.|  .. |         . |. . .|..    |..|.|...| . ||||..||
sltlsWsppkdgggpitgYeveyrekggge......ewkeft.vprttt.svtltgLkpgteYefrVqavngag
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2417-2628 2.9e-09 30.8 In-house 72-284 (302) alignment 
Range on Protein: 2417-2628
Range on HMM: 72-284/302.0
EGQTNYVNATFLDGF--NrRDMYIaTQMPLQHTV---EDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWP--AGDEALIGPFVIDVSAEEREGDVIiRTF
. . .||||. ..    . | ... .|.| . ..   |.||||... .   .|.|   .  ..| |...|  .||    | . . .   |.  .     .
aepdsyvnaskvevPelt.rsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.try

LLSNTNTVATEsSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVeAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSG
 .       .. | ..  | .  ||.  | |.. |.|      |   .   .. .. .  . |. | | | . . .. ||... .  .   ||..|.   
viEvlPegcsn.svlanvyvltnWkqk.kvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRp

RMVPSEEQYLYIHDVVREY
|.| | .||  .. ..  |
ravdslkQyvslyiallly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2417-2483 5.2e-09 29.9 In-house 87-156 (349) alignment 
Range on Protein: 2417-2483
Range on HMM: 87-156/349.0
EGQTNYVNATFLD--GFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWPAG
    .|.|| .|    ..    |||||.||  ||.||...|   . .... ||. . .  . | .||  .
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2439-2622 6.6e-09 29.6 In-house 95-281 (302) alignment 
Range on Protein: 2439-2622
Range on HMM: 95-281/302.0
ATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWP--AGDEALIGPFVIDV-SAEER------EGDVIIRTFLLSNTNTVAtESSRVIRQY
   .| . |.| .| .| .||  ..| | .. . ... |..|.    |.|   | . .   | ..         .. . |  . |...   .  . .   
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdil

SFVGWKERQkYPKSLASLLCLLDLVEAGQRDlgngpITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIH
 | .| .    ||   . | .|   |. ...     . |||  || |.| . ||   |   . .   |. . |. .|.|    | .|.| .|. 
afsawpdhG.apkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2420-2503 7e-09 30.1 In-house 13-92 (130) alignment 
Range on Protein: 2420-2503
Range on HMM: 13-92/130.0
TNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDqtcsQYWPAGDEALIGPFVIDVSAEEREGD
 .|.|| |.   .|   |. || ||  |  |||.|. .   ||.|.|  .. .|    .|||  .        | |.  .|.. 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdef
0038934 (Phosphotyrosine protein) phosphatases II 2222-2322 1.1e-07 27.2 In-house 67-165 (194) alignment 
Range on Protein: 2222-2322
Range on HMM: 67-165/194.0
RKAWDPEERRV--QHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR-PSGPTIVHCSAGVGRTGTyFTIDSMMDMsareQQINVLDFVYRMRTKRVKMVQ
 . .||||      ...   .|| | . |   ||.|.  |.|| .. |.|   ||| ||.||||| . .  .. .    ..... . ....| || ....
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGt.lvaaYLiyr....lgmsaeeAialfrekRpgaip

TPEQ
....
nqdy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2388-2475 1.1e-07 25.7 In-house 30-116 (332) alignment 
Range on Protein: 2388-2475
Range on HMM: 30-116/332.0
KSSENHHKNRYPDNIPLDKYRPYLMtgCSEGQTNYVNATFLDGFNRRDMYIATQMPLQ-HTVEDFWRMIYDYNSNVIVMLNEINRNDQT
|  .|   || |    .|. |  |     .|. .. ||...||....  || .| |.. ||   ||||. . . ..|... .|. ... 
kflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2380-2441 2.1e-07 25.0 In-house 36-94 (95) alignment 
Range on Protein: 2380-2441
Range on HMM: 36-94/95.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTgcsEGQTNYVNATFLDGFNRRDMYIATQ
|  .  .| |  |  |||. . .| |  |  | |     ...|.|| |.||. |.. |||.|
sgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2413-2470 3.5e-07 24.1 In-house 63-120 (347) alignment 
Range on Protein: 2413-2470
Range on HMM: 63-120/347.0
TGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN
.. ..   .|.||. .   | .  || || || .|| |||.|..  .   .| . |  
nsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_eak_pd Subfamily eak 2264-2335 4.2e-07 23.7 In-house 233-306 (332) alignment 
Range on Protein: 2264-2335
Range on HMM: 233-306/332.0
ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA--REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
. ||   |. .. |  |.|..  || .. .    ..    | |.. ....||.. | .  |. ||||..|. ||
tppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_PTEN_pd Subfamily PTEN 2252-2327 7.4e-07 24.3 In-house 98-175 (184) alignment 
Range on Protein: 2252-2327
Range on HMM: 98-175/184.0
LLEFITKVKEF-EARPSGPTIVHCSAGVGRTGTYfTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFI--Y
| |........ |. ..   .||| || ||||.  ..  .. .   |.. ..|..  ..|||  | |. | |  ..  |
leeivediekwleedkknvvvvHCkaGkGRtGvl.ivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy
hEGF Human growth factor-like EGF 239-251 9.1e-07 17.6 Pfam-A 1-13 (13) alignment 
Range on Protein: 239-251
Range on HMM: 1-13/13.0
ECVCPPGFTGQLC
.|.||||.||. |
tCqCppGyTGpnC
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2440-2630 1.5e-06 21.1 In-house 123-310 (346) alignment 
Range on Protein: 2440-2630
Range on HMM: 123-310/346.0
TQMPLQHTVEDFWRMIYDYNSNVIV-MLNEINRNDQTCSQYW-PAGDEALIGPFVIDVSAEEREGDVIIRTFL-LSNTNtvateSSRVI-RQYSFVGWKE
 ||  .  ||||| |||. . ...  |. . . .. | | .    |     | ..|.    .  ||    |   | . |     |  || . .    || 
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegn.....sdsvicqvhhhapwkh

RQKYPKSLASLLCLLDLVEagQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 |. ||.|  .  . ..    .... |  . |  . |  |.  |   . .| .|    . ...  .|....     | |  ||  |. .| .|.|
lqqppktlpiikmihqfls..ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
fn3 Fibronectin type III domain 461-539 2.8e-06 20.6 Pfam-A 6-80 (85) alignment 
Range on Protein: 461-539
Range on HMM: 6-80/85.0
PTIVTVNSDAVELAWNAWNaavdTGSGPVTAYIVQSREHGVAAWETAGNVTEGPFTFTVMSLGSRITYDFQVVAVRPGL
...  |.|. ..| |.. .    .|.||.| | |. || |   ...  .|..   ..|.  |    .| |.| ||  . 
lsvsevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_PTPDC1_pd Subfamily PTPDC1 2234-2326 3.7e-06 21.5 In-house 84-168 (182) alignment 
Range on Protein: 2234-2326
Range on HMM: 84-168/182.0
HFHYTSWPDMGLPlSATPLLEfITKVKEFEARpSGPTIVHCSAGVGRTGTYftIDSMMDMSareQQINVLDFVYRMRTKRVKMVQTPEQYVFI
 ..  .|.| | . | . .|. | || .|  .  | . ||| || ||||    | ...  .   ....  . .  .| || | .|| ||  ..
yvynfgwkDygva.sleriLd.ivkvvafalq.egkvavhChaGlGrtGvl..iacylvya...krltaekaiklvrskrpksiqtreqvelv
fn3 Fibronectin type III domain 1073-1155 6.5e-06 19.4 Pfam-A 6-85 (85) alignment 
Range on Protein: 1073-1155
Range on HMM: 6-85/85.0
VMVVDVmerTQSSLKFRWNTLEcgDRHGPEVIYHYRLESPSGL-YWNGQVHDPES-LAAVYGLLPCLMYSFKVQAETSAGFGEPS
. | .|   | .|| ..|.  .  |..|| . |  .... .|  .|. .  .. .  . . || |   |.|.||| . || |..|
lsvsev...tstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 561-644 8.1e-06 19.1 Pfam-A 3-73 (85) alignment 
Range on Protein: 561-644
Range on HMM: 3-73/85.0
IPSLSVSSIpnKSTSLLVTWEPTLERRCDVAYYIIHYditrfD-----QcadrkatsgsdVSQSGTFNTTETSWTINGLNEYSSYVVFV
.  ||||..   |||| ..|.|  ... .. .| ..|           .           .... |   |.|| |..||.....|.. |
Penlsvsev..tstsltlsWsppkdgggpitgYevey.....rekggge...........ewkeftvprtttsvtltgLkpgteYefrV