Gene SpurPTP-sf4-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP105_AA protein Get Run
SpurP105_AA_2061-2335 phosphatase_domain Get Run
SpurP105_AA_2347-2630 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 2057-2408 9.9e-127 418.9 In-house 3-354 (564) alignment
Range on Protein: 2057-2408
Range on HMM: 3-354/564.0
PAVKIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
..... ||  .|..  ||... |. .|...  ||  |||.|. ..| .|||| ||..||||||.| . .  .  |||||||. || |.||||||||||..
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEF
|. |||||||.... .|||||||.|..| ||. ||||.  ||||..| |...| .. .|. ||....|. . | | |..||.||||| | | |||.||..
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

ITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQ
|.||.. . . .||..||||||||||||. .||.|..    |.....  .| ..|..|  ||||.|||.||.||.|| | || |.|..... | ...|..
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLae

TNLHTKRTFLEEHLSALDaMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYR
.. .|. | ||     |   .      ...... ..|..|||... ..|.. |
veedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescr

0051299 (Phosphotyrosine protein) phosphatases II 2059-2334 1.5e-100 331.7 In-house 5-286 (288) alignment
Range on Protein: 2059-2334
Range on HMM: 5-286/288.0
VKIVELSGYVKEKTANGEMCFKLDYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTT
... ||  .|....||| . ..  .|.|.. . ..|. .| ..||..|||| .|.|||||||.| . .. .. ||||||...|| .....|||||||..|
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

VFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP-EDIETYGDFTLTVVAERNYLNYTERTLTIRKA----WDPEERRVQHFHYTSWPDMGLPLSATPL
| |||||||...|.||||||||||....||..||| .. .||||.| | . |  . .|| |||....     .| |.|.|.|||||.|||.| | |...|
vedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
|.|. .|... | ..||..||||||||||||. ..| ....  .|. ..||..| |.|..|  ||||||||.|.||||||.|
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2061-2368 1.7e-100 331.0 In-house 8-313 (315) alignment
Range on Protein: 2061-2368
Range on HMM: 8-313/315.0
IVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFD
. .|  || .| |. .  || ||| .| ||..  .|| . ||. ||||||||.||.||| |      || ||.||.|. || |.. |||.|||. ..| |
ldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkd

FWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIrkAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVK
|||.|..| .  |||||.|||..|||.. |||..  .|| .|.| . |  . .|| |||..    . . | |  .|||||||||.| ...||...| .||
fwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswpdmgvpkytiplmnlirtvk

EFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQTNLHT
 ..    |. .||||||||||||. |.|...|    |. |.| .|. ..| .|.||||. ||| |||.|||| ..|| ||.  .  .| .  |   .  |
qhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapspdt

KRTFLEEH
  |.|.|.
gstllqeq

0050432 (Phosphotyrosine protein) phosphatases II 2073-2339 4.2e-99 327.0 In-house 38-304 (308) alignment
Range on Protein: 2073-2339
Range on HMM: 38-304/308.0
ANGEMCFKLDYERLPDGQM-YTWEVATRQENVSKNRYINIIPYDHSRVILdtdpDaPHEDYINASFVSGY--LKPKAYIATQGPLSTTVFDFWRMVWQER
|..   ..  .|.|.. .  ....|| ..||..|||| .|.|||||||.|    | .. ||||||.|.||   .|...|||||||..|| |||||||...
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

VPVIVMLTKLVENKKRKCDPYWPE----DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEar
|.|||||||||||.. ||..|||.    ....||.||.|.. | .. .|| |||....  |.|.|.|.|||||.|||.| | |...||.|. .|...   
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYT
|.||..||||||||||||. ..| ....  .|. ..|.. |...|..|  ||||||||.|.|.|||| |.. .|
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

0040438 (Phosphotyrosine protein) phosphatases II 2065-2348 7.4e-98 323.0 In-house 6-290 (317) alignment
Range on Protein: 2065-2348
Range on HMM: 6-290/317.0
SGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRM
  ...   ... . ..  .|.|.. . .|..|| ..|| .|||| .|.|||||||.|  ..  .. ||||||.|.|. .....|||||||. ||.|||||
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

VWQERVPVIVMLTKLVENKKRKCDPYWP-EDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE
||...| ||||||.|.|....||..||| ..  |||||| |.. |  . ..| |||.. .  |.|.|.|.|||||.|||.|.| | ..||.|. .|.|. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQ
..|.||..||||||||||||. ... |...  .|....| . |...| .| ..|||||||.|.|.|||| |....|..| .  . 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselkl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2059-2366 1.3e-96 318.4 In-house 2-312 (318) alignment
Range on Protein: 2059-2366
Range on HMM: 2-312/318.0
VKIVELSGYVKEKTANGEMCFKLDYERL-PDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTT
... .|   |..  ..||. .. .|||| .. .  |.  .. . |  ||||.||..|||.|| |..  . .  |||||... || . |||||.|.||. |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFI
. |||||||.    ||||||...|. |.|.. |||..  ..||. . ..  | .. .|. |......    |.| |. .||||||| |.| |.. ||...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

TKVKEFE-ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQ
 .|.. .     ||..|||||||||||.. ..|....  . |. ..|...| ..|..|  |||| .||.|||..||| | .| | | .. . .   .|..
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

TNLHTKRTFLE
.. .. .| ..
qdpesgttemd

0046845 (Phosphotyrosine protein) phosphatases II 2082-2340 3e-96 317.4 In-house 5-280 (284) alignment
Range on Protein: 2082-2340
Range on HMM: 5-280/284.0
DYERLPDGQM---YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDA-PHEDYINASFVSGY-----LKPKAYIATQGPLSTTVFDFWRMVWQERVPV
..|.|.  ..   ....|| ..||.||||| .|.|||||||.|.. ..  .. ||||||.|.||      ..|..|||||||..|| |||||||...|.|
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLTKLVENKKRKCDPYWP--EDIETYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA--RPS
|||||.||||.. ||..|||  ..  |||||| |.. | .. .|| |||....   . |.|.|.|||||||||.| | |...||||. .|.|.     ..
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

GPTIVHCSAGVGRTGTYFTIDSMMDMSAREQ---QINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTS
||..||||||||||||. ..| ....  .|.    ..||. |.|.|..|  ||||.|||.|.||||||.|....| 
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

subfamily_PTPRG_pd Subfamily PTPRG 2060-2348 2.5e-95 314.8 In-house 2-301 (563) alignment
Range on Protein: 2060-2348
Range on HMM: 2-301/563.0
KIVELSGYVKEKTANGEMCFKLDYERLPDG---QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHE-DYINASFVSGYLKPKAYIATQGPLS
.. |.. .| .  |.|.. |. ..| |      .  . | . ..||  ||||.||..||.||| |   |.  .. |||||... || | ||.||||||| 
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

TTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRK-----AWD-PEERRVQHFHYTSWPDMGLPLS
.|. |||||.|...| .|||.|.|||...|||| |||.|  |||| ...| ..|     ||.|||.|..       .  .|..|...|||.|||.| | .
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

ATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQ
..| | |. | .  . .  ||..|||||||||||||  .|...    .|...||..|. ..|..|  .||| |||.|...||||... . | . .. . .
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee





0043336 (Phosphotyrosine protein) phosphatases II 2060-2332 3.6e-95 313.9 In-house 3-275 (278) alignment
Range on Protein: 2060-2332
Range on HMM: 3-275/278.0
KIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVF
.. .|  ...|. .|.  ...|..|.|.. . .|...| ..||..|||| .|.|||||||.|. ..  .. ||||||.|.|| .|...|||||||. || 
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKV
|||||||...|..|||||.|||... ||..|||.. .|||||| |.. |  . .|| |||.. .  |.|.| |.|.||..|||.|.| | ..||.|. .|
dFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

KEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.|. . ..||..||||||||||||. ... ....  .|. ..... | ..|..| ..||||.||.|.||||||
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_PTPRK_pd Subfamily PTPRK 2057-2355 1.7e-94 311.2 In-house 2-298 (314) alignment
Range on Protein: 2057-2355
Range on HMM: 2-298/314.0
PAVKIVELSGYVKEKTANGEMCFKLDYERLPDGqmytWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
||... .|   ..   ..    || .|| |..|    |..| ..|| .|||. .|..||.|||.| |  . |. |||||... .| .|.|.|.|||||  
pairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIRK--AWDPEERRVQHFHYTSWPDMGLPLSATPLLE
|| ||||.|..|.   |||||.|||. . ||  ||||| |.|||. ...|      ..  |.....|      | | |..|....||| . | ||| ||.
tvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

FITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
.. .||. ..   |...|||||| |||||. .||...||  ||. ..|   |  .|...| ||.| |||.|||...||. ||| |..|.  .   .    
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

Q
.
r

0047943 (Phosphotyrosine protein) phosphatases II 2071-2334 2.2e-94 311.2 In-house 6-272 (273) alignment
Range on Protein: 2071-2334
Range on HMM: 6-272/273.0
KTANGEMCFKLDYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILdtdpDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQER
....|  .... .|.|.. . ..|..|| ..|| .|||| .|.|||||||.|    . .. ||||||.|.|| .....|||||||. || |||||||...
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VPVIVMLTKLVENKKRKCDPYWPED----IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR
|.||||||.|||....||..|||..     .|||.|| |.. | .. .|| |||....  ..|.| |.|||||.|||.| | | ..||||| .|... . 
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
   .||..||||||||||||. ..| ..|.  .|....||. |...|..|  ||||||||.|.||||||.|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPRB_pd Subfamily PTPRB 2058-2334 1.3e-93 308.3 In-house 6-285 (293) alignment
Range on Protein: 2058-2334
Range on HMM: 6-285/293.0
AVKIVELSGYVKEKTANGEMCFKLDYERLPD-GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
 .|. .....||...|. .. |. .||.| . |.  . ..|....| .|||| ||.||||||| | .  | ...|||||....||  |. .||||||| .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED--IETYGDFTLTVVAERNYLNYTERTLTIRKawDPEERRVQHFHYTSWPDMGLPLSATPLLE
|| |||||||.... .|||||.|||. | ||. |||.|    .||| ..|.|||... ... |.|.|.|  . |||.|...|.||||| | | ....||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FITKVKEFE--ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
|. .|.|    .  ..|..||||||||||||. ..| ...   .|. .... .|...|..|. .||| .||.||....|. |
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2059-2367 2.2e-93 307.8 In-house 5-316 (319) alignment
Range on Protein: 2059-2367
Range on HMM: 5-316/319.0
VKIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTV
... ||  ..|.  ..||. .. ... |  ..  |.. |...|| .|||| ||..||..||.| . .. .  |||||||. || . ...||||.||..|.
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

FDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFI
 |||||||.|.. ..||||||||. | |.  ||||   |.|| ...|.  |..  .|  | |...|.  . | |.|.||.||.||| . | .|| ||...
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

TKVKEFEAR-PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQ
 ....   .  ||| .||||||||||||. ..| |..   .|. ..|  .| |.||.|  |||.|||| |||||||| . .| | .  . . . . .|..
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlae

TNLHTKRTFLEE
 .  |  | || 
kvadtgetgler

0036941 (Phosphotyrosine protein) phosphatases II 2082-2343 2.2e-93 308.1 In-house 18-286 (297) alignment
Range on Protein: 2082-2343
Range on HMM: 18-286/297.0
DYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILdtdpDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLV
 .|.|.. . .....|| ..||..|||| .|.||||.||.|    | .. ||||||.|.||  ....|||||||..|| |||||||...|.||||||.||
efeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelv

ENKKRKCDPYWP---EDIETYGDFTLTVVAERN--YLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR--PSGPTIVH
|. . ||..|||   ..  ||||||.|.. .    . .|| |||.. .  ..|.|.|.|||||.|||.|.| |...||.|| .|... .   ..||..||
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

CSAGVGRTGTYFTIDSMMDMSA---REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPT
|||||||.||. ..| |...     .|.....|..|  .|..|  .|||.|||.|.|||||| |....| .| 
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl

0039614 (Phosphotyrosine protein) phosphatases II 2067-2338 4.8e-93 307.1 In-house 22-293 (297) alignment
Range on Protein: 2067-2338
Range on HMM: 22-293/297.0
YVKEKTANGEMCFKLDYERLPDGQMYtWEVATRQENVSKNRYINIIPYDHSRVILDTDPDA-PHEDYINASFVSGYLK-PKAYIATQGPLSTTVFDFWRM
... ..||. ....|..|.|.. .   ...| ..||..||||..|.|||||||.| . ..  .. ||||||.|.|| . ....|||||||. || |||||
llllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VWQERVPVIVMLTKLVENKKrKCDPYWPEDIETYGDFTLTVVAERNYLNYTERTLTIRKawDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA
||...|.||||||||||... ||..||||. .|||||| |.. .  . .|| |||....  . |.| |.||.||.|||.| | |.. ||||. .|.|. |
vweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreala

R--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
.  ..||..||||||||||||. ... |...  .|....||. | ..| .| ..||||.||.|.|.|||| |....
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

subfamily_PTPRA_pd Subfamily PTPRA 2058-2368 6.1e-93 306.3 In-house 13-329 (330) alignment
Range on Protein: 2058-2368
Range on HMM: 13-329/330.0
AVKIVELSGYVKEKTANGEMCFKLDYERLPDGQM-YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
 . . .|   .. ..|.    |. ... || |..  | |.|...||  |||..||.|||.||||| .    .. |||||||. || . . .||.|||.. 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWD----PEERRVQHFHYTSWPDMGLPLSATP
|| |||||.|. .   |||||.| | |. ||  |||.. . |||. ...|  |    .|| | . ...  |     ..| |. ||.|||||.|.|  .  
tvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFT
.|... |||. . . .|| .||||||||||||. ..|.....   |....| .|| |.|..| .|||| |||.|||..|||  | | | .   .. ... 
mlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

RLEQTNLHTKRTFLEEH
.| ..  .|... ||| 
klynkitgtdkigleee

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2066-2341 1.3e-92 305.3 In-house 16-297 (298) alignment
Range on Protein: 2066-2341
Range on HMM: 16-297/298.0
GYVKEKTANGEMCFKLDYERLPDGQM----YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDF
 ... | ... . ..|...||  ..      ..||| ..|| .|||| .||..|.|||.| .. .  . |||||||...| . .|.||||.|| .|| ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMVWQERVPVIVMLTKLVENKKRKCDPYWPE-DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVK
||||..| . .|||||.|.| .| |.  |||.   ||||..|... .. .. ... |.|.. |.   .||.|...|.||||| | |  || .|....||.
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

EfEARPSG--PTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSV
    . .|  | ||.|||||||.||.  |||...   .|| . |.. | ..|.||...||| ||||||||| || | .. . .
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0045450 (Phosphotyrosine protein) phosphatases II 2063-2335 1.5e-91 302.6 In-house 13-305 (307) alignment
Range on Protein: 2063-2335
Range on HMM: 13-305/307.0
ELSGYVKEKTANGEMCFKLDYERLPDGQM---YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDA-PHEDYINASFV--------SGYLKPKAYIAT
 |  .|....... . ..  .|.|.. .    .....| ..|| .|||| .|.||||.||.| . ..  .. ||||||.|        .|| .....|||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED--IETYGDFTLTVVAERNYLNYTERTLTIRKA-WDPEERRVQHFHYTSWPDMGLPL
||||. || |||||.|...| ||||||.|||....||..|||..    |||.|| |.. |  . .|| |||..     . |.|.|.|||||.|||.|.| 
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SATPLLEFITKVKEFEAR--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQ---INVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
|  .||.|| .|... ..  ..||..||||||||||||. ... |...  .|.    ...|. | ..| .| ..||.||||.|.|||||| ||
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

DSPc_SM00195 2093-2333 2.2e-90 297.9 In-house 17-261 (263) alignment
Range on Protein: 2093-2333
Range on HMM: 17-261/263.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
. . | ...|.||||| ||.||||.||.|..... ...|||||....|. |.|.||||||||..|| |||||||.|.|..|||||. .||.|.||| |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

EDI---ETYGDFTLTVVAERNYL-NYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTID
|..   ||.|......| . ..  ... |||...|  . |.|.|....|..||| |.| |....||.. .||. . . |||..||||||||||||. |||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
....  ..|..... . | ..|..| .|||| ||| |||||.||.
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 2093-2333 2.2e-90 297.9 In-house 17-261 (263) alignment
Range on Protein: 2093-2333
Range on HMM: 17-261/263.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
. . | ...|.||||| ||.||||.||.|..... ...|||||....|. |.|.||||||||..|| |||||||.|.|..|||||. .||.|.||| |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

EDI---ETYGDFTLTVVAERNYL-NYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTID
|..   ||.|......| . ..  ... |||...|  . |.|.|....|..||| |.| |....||.. .||. . . |||..||||||||||||. |||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
....  ..|..... . | ..|..| .|||| ||| |||||.||.
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2060-2346 2.5e-90 297.7 In-house 5-295 (305) alignment
Range on Protein: 2060-2346
Range on HMM: 5-295/305.0
KIVELSGYVKEKTANGEMCFKLDYERLPDGqMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVF
 . .|. |.||.... .  .. .|. |..    . .| ....|..|||. .|...|..|.|| .... ...||||||.| || . |.||..|||| .|| 
alddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIET---YGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEF
||||....|.| .|||||||||..| ||  |||| .     .|.|....  |... .|.|| |.| .   | |.| | ... |.||| | | .|| ||..
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

ITKVKEFEARPSG-PTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTI
| .|..   .  | | .|||||||||||.. ..| ...   .|....| . . ..|.||.||||| .||||...|| | . ||.||.  . .
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2067-2332 4e-86 283.6 In-house 11-277 (288) alignment
Range on Protein: 2067-2332
Range on HMM: 11-277/288.0
YVKEKTANGEMCFKLDYERLPD-GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMV
.|..| |...  |. .|. |.  ..  . ... . .| .|||| ||.|||. || |.  .. . .||||||.. |. | |.||||||||  || |||..|
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WQERVPVIVMLTKLVENKKRKCDPYWPEDIE--TYGDFTLTVVAERNYLNYTERTLTIRKawDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE
.....  |||||.|||. |.||. |||.. .   ||..|.|.| ...  ....|.| . |  . .|.......|..|||.| | |..||||....||  .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllek..kkteleitqyqylaWpdhgvPeskapllellrqvkvan

ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
   .|| |||||||||||||. ..| ..|.  .|..|.|...| ..| .|  .||| .||.||||.||.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

0040439 (Phosphotyrosine protein) phosphatases II 2093-2334 4.7e-85 280.4 In-house 2-246 (249) alignment
Range on Protein: 2093-2334
Range on HMM: 2-246/249.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
...|| ..||..|||| .|.|||||||.|   |. .. ||||||...||  ....|||||||. || |||||.|.... ||||||.|||... ||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-EDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR--PSGPTIVHCSAGVGRTGTYFTIDS
 ..  .||||| |.. .  . .|| |||.. .  |.|.|.|.|..||.|||.|.| |  .||.|| .|... ..  ..||..||||||||||||. ... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
|...  .|....... |  .|..| ..||.||||.|.|||||| |
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2078-2409 5.6e-85 280.4 In-house 19-351 (515) alignment
Range on Protein: 2078-2409
Range on HMM: 19-351/515.0
CFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLT
 |  ..  ||  ..|   ||  . | .|||| ||.||| .||.|.   |.||.||.|||.. ..   |||||.|||. ..| ||||.|.||.|  |.|.|
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

KLVENKKRKCDPYWPE---DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDpeERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHC
|| |. | ||  |||.   |   .| . . .|.     . . |.||. |  |   | |  ||.| ||| | |  .. || .| .||  . . . | |.||
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihc

SAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLEQTNLHTKRTFLEEHLSALDA
|||||||| . .|||..   .  . ..|..||  .| ||...||| ||| |||.|.|| ||   | .|   . ...  |  .     |. . ..  .| .
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks

MSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRP
.         ..|.. .|| |||| .|.||.. | 
lcpdppasqtrsgrtrdnhpknrygnnlplqrnrv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2096-2336 5.6e-85 279.5 In-house 3-244 (250) alignment
Range on Protein: 2096-2336
Range on HMM: 3-244/250.0
VATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRkCDPYWP-ED
|| . .|  |||| .||..|.|||.| ..    . |||||||. || . ||.|||||||..|. ||||||..| . .|||||.|.|..|  .  ||| | 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR-PSGPTIVHCSAGVGRTGTYFTIDSMMDM
 |.||| |...  . .. .|| |.| . ||   .|| |...|...||| | |  ||  ||...||.  . .  ..| ||.|||||||.|.. .||.... 
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
  .|....| ... ..|..|...|.. |||||.||..|. | .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

Y_phosphatase Protein-tyrosine phosphatase 2102-2332 8e-85 279.4 Pfam-A 1-235 (235) alignment
Range on Protein: 2102-2332
Range on HMM: 1-235/235.0
NVSKNRYINIIPYDHSRVILdtDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP---EDIETY
| .|||| .|.|||..|| |  . .  ..|||||..|.|| ..|..|||||||. |. |||||||||.| ||||||.|.|....||..|||   |. .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDFTLTVV-AER-NYLNYTERTLTIRKAWDP-EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA
||......  |  .  .|| |.|...|  .. |.|.|...|||.||| |.| |...||..|.||.. ..  |||..||||||||||||. ..| ....  
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.|....||..| ..|..| .|||. |||.|.|.|.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 2102-2332 8e-85 279.4 In-house 1-235 (235) alignment
Range on Protein: 2102-2332
Range on HMM: 1-235/235.0
NVSKNRYINIIPYDHSRVILdtDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP---EDIETY
| .|||| .|.|||..|| |  . .  ..|||||..|.|| ..|..|||||||. |. |||||||||.| ||||||.|.|....||..|||   |. .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDFTLTVV-AER-NYLNYTERTLTIRKAWDP-EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA
||......  |  .  .|| |.|...|  .. |.|.|...|||.||| |.| |...||..|.||.. ..  |||..||||||||||||. ..| ....  
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.|....||..| ..|..| .|||. |||.|.|.|.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0045098 (Phosphotyrosine protein) phosphatases II 2081-2337 4.1e-83 274.2 In-house 12-275 (278) alignment
Range on Protein: 2081-2337
Range on HMM: 12-275/278.0
LDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVIldtdpdapheDYINASFVSGYlkPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLV
  .. |. |.......| . .|..|||| .|.|||||||.          ||||||...||  ||..||||||| .|| |||||.|.....||||||.||
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

ENKKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRKA----WDPEERRVQHFHYTSWPDMGLPLSA--TPLLEFITKVKEFEAR--------
|... ||..||||.  .||||||.|.. | .. .|| |||...       | |.| |.|.||..|||.| | .   ...||..  ..|. ..        
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----PSGPTIVHCSAGVGRTGTYFTIDSMMDMSarEQQINVLDFVYRMRTKRVK-MVQTPEQYVFIYEALLECLLCG
     ..||..||||||||||||.  .. |...   |.....|. |  .|..|   .||..|||.|.||.||| ||.|
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2067-2334 6.3e-83 273.1 In-house 5-276 (281) alignment
Range on Protein: 2067-2334
Range on HMM: 5-276/281.0
YVKEKTANGEMCFKLDYERLPD-GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMV
 .|....| .  |. .|| | . |.  | . ....||| ||||.||. ||..|| .  . .. . |||||.||.|| ..|.|||||||. ... .||.||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WQERVPVIVMLTKLVENKKRKCDPYWPEDI--ETYGDFTLTVVAERNYLNYTERTLTIrKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE
|...| .|||.|. .|. | ||  |||.|    .|||.|.. .||..  .| ||.... .. . |.|.|....||.||| | | ... |||| ..|....
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

ARPS-GPTIVHCSAGVGRTGTYFTIDSMMDMSARE-QQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
 . .  | ..|||||||||||| ..| ...  ..| ....| . |  .| .|  ||||  || |.| |.|. |
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0042113 (Phosphotyrosine protein) phosphatases II 2095-2332 9.7e-83 272.6 In-house 2-241 (245) alignment
Range on Protein: 2095-2332
Range on HMM: 2-241/245.0
EVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP-E
.|| ..||..|||| .|.||||.||.|  |.  .. ||||||.|.||  .. .|||||||. || |||||.|.... .|||||...|... ||..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA-RPSGPTIVHCSAGVGRTGTYFTIDSMMD
.. |||||| |.. | .. .|| |||.. .  |.|.| |.|.||..|||.| | .   ||.|.  |... |  ..||..||||||||||||. ... |..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.  .|. ... . |...| .| ..||||.||.|.||||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPN6_pd Subfamily PTPN6 2069-2331 3.6e-82 270.8 In-house 18-294 (306) alignment
Range on Protein: 2069-2331
Range on HMM: 18-294/306.0
KEKTANGEMCFKLDYERLP---DGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDtDPDAPHEDYINASFVSGYLK--PKAYIATQGPLSTTVFDFWR
||..  .   |. ..|.|      .... . ....|| .|||| ||.|.||.||||  .|. | .|||||..... .|   |.|||||| |.||| ||||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MVWQERVPVIVMLTKLVENKKRKCDPYWPEDI--ETYGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVK
|||||   ||||.|| ||  | || .|||.    |.||. ..| |.|..  .|. |.|.. |   . |||.| ..|..|||| | | .   .|.|...|.
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

----EFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAR---EQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
    |.|.. .||..||||||.|||||.  || ....  .   . .|.. ..|  .|. |  .||| .|| |.|.|. 
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

subfamily_PTPN12_pd Subfamily PTPN12 2085-2333 4.4e-81 267.0 In-house 23-276 (290) alignment
Range on Protein: 2085-2333
Range on HMM: 23-276/290.0
RLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKK
.. . ..|. |.....||| |||| .|.|||.||| | .. . ...|||||.|. |  ....|||.||||..|. |||||.|. .| ..||. ..||..|
kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

RKCDPYWPEDIE---TYGDFTLTVVAERNYL-NYTERTLTIRKAwdPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGR
 ||. ||||  |   ..|.|..|. .|..   ... |||....    |.|.|. ||||.||| | | ||..|||.|..|.|.. . . | .|||||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

TGTYFTIDSM---MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
|||  .|| .   .     .....| | | ..|..|. .||| |||...|.|..| 
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Ptp69D_pd Subfamily Ptp69D 2058-2352 1.4e-80 265.7 In-house 3-304 (307) alignment
Range on Protein: 2058-2352
Range on HMM: 3-304/307.0
AVKIVELSGYVKEKTANGEMCFKLDYERLPDG-QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLST
|..|..|.  .| .  . .. .. .||.|.      . .|. ..||  |||| .|...|. ||.| . .   . |||||||. || . | .|| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP-EDIETYGDFTLTVVAERNYLNYTERTLTIRKAW-----DPEERRVQHFHYTSWPDMGLPLSAT
|..|||||...  | .||||..| | ...||. ||| ||.  |||   ..| |..  .|..|.| . |        ...|.|  .|||.|.|.  | .|.
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

PLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYF
 ||..|..|.| .    .| .|||||||||.|.. ..||...    |..... ..|  .| .|  .||  |||||.| |||.    | | .  ... . .
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

TR
 |
er

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2077-2350 3e-80 264.4 In-house 19-293 (315) alignment
Range on Protein: 2077-2350
Range on HMM: 19-293/315.0
MCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVML
  |  ..  ||| ..|   ||  ..| .|||| ||.|.|..||.|.   | |..||||||.. .. . |||||.|||| ..| ||||||.||.|  |||.
alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TKLVENKKRKCDPYWPE---DIETYGDFTLTVVAERNYLNYTERTLTIRKAwdPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVH
||. |. | ||  |||.   |   .| . ....      . . | |..||.   | |.|  |..| ||| | .  .. ||..| .||  . .   . .||
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

CSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYF
|||||||||   .||....  .|.. ..|..||  .|.||...||| |.| |||.|.|| ||   | ..   .....
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl

subfamily_PTPN9_pd Subfamily PTPN9 2060-2333 3.3e-79 261.0 In-house 2-289 (297) alignment
Range on Protein: 2060-2333
Range on HMM: 2-289/297.0
KIVELSGYVKEKTANGEMCfklDYERLPDG-QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTV
.| ||  |||||  .| .    .|. . .     | ...  . |..|||| ... ||..|| | . .. .. |||||.|| || ..||.|||||||  ||
eieelvayvkekgkrGlsk...eyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktv

FDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP---EDIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEF
 |||||||...| |||| |..||....||  |||   |. . .||.....|  ... .|..|.|.|... . |.|.| || ..|||| | | ||. ||..
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

ITKVKEFEA------------RPSGPT-IVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
. ||.|  |            .||||  .||||||.|||||. |.|  ..   ......| . | ..||.|  ..||||||.| | |.|| 
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

0037934 (Phosphotyrosine protein) phosphatases II 2094-2332 1.4e-77 255.8 In-house 2-240 (243) alignment
Range on Protein: 2094-2332
Range on HMM: 2-240/243.0
WEVATRQENVSKNRYINIIPYDHSRVILdtdpdaPHEDYINASFVSGYlkPKaYIATQGPLSTTVFD----FWRMVWQERVPVIVMLTKLVENKKRKCDP
. .| ..||.||||| .|.|||||||.|      . .|||||... ..  |. .|||||||. ||.|    ||||.|.... ||||||.|||... ||..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPEDIeTYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEF--------EARPSGPTIVHCSAGVGR
|||... |||||| |.. |... .|| |||...    |...| |.|.||..|||.| | | ..||.|. .|.||         . ..||..|||||||||
ywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTYFTIDSMMDMSareqQINVLDFVYRMRTKRVK-MVQTPEQYVFIYEALLE
|||. ... |...     ...... | ..|..|   .||||.||.|.||||||
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2338-2633 1.7e-76 252.3 In-house 2-294 (298) alignment
Range on Protein: 2338-2633
Range on HMM: 2-294/298.0
YTSVPTKTIVQYFTRLEQTNLHTKRTFLEEHLSALDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMY
 | . .... . ...|.. . ..| | ...    |...|    . ........||..||||.| |.||. |  | .  .. ...|.||.||.....|. .
nteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnaf

IATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVateSSRVIRQYSFVGWKER
|||| ||..||||||||. ......||||....  |. ....|||   ..  | . ... ..|. .|.|.|.. .|....    ..| .|| .|. | ..
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdk

QkYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
.  |.   |.| ||. |.| |.. || |..|.| .||.||| |.|| | . ..| |  .|||..|| |||    .| .|||| .|...| |.|.| .
g.vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

subfamily_PTPRD_pd Subfamily PTPRD 2383-2633 5.1e-76 251.5 In-house 39-285 (564) alignment
Range on Protein: 2383-2633
Range on HMM: 39-285/564.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWP
...| . ..| .|||| . .. |. |  | .   . ...|.||.|.||...|  ||||| ||..|.||||||....||..||||.... .  . |..|||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

AGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQrDLGNGPITVHCMDGVTRSGLFCA
. ... .| .......||.  |..|||| |....   ...|| .||. |. | ..   |.| .||| |.. |.| .   ..|||.|||  || |.| |..
ekgtetygeltVtleeeeeladyeirtfklkkkk...ssesreVrqFhFtsWPdhg.vpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfiv

IMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
| . . ..|.|...|..  ||.|||    || .|||| .||... |.||. .
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2056-2367 2.3e-74 245.4 In-house 2-321 (325) alignment
Range on Protein: 2056-2367
Range on HMM: 2-321/325.0
PPAVKIVELSGYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLS
| .. .|.|  .|..| |. .  |  ... ||  .  . .||.. ||..|||. |....|.|||.| |  |.|. ||||||..  . | . ..|.| ||.
pgsiavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlt

TTVFDFWRMV--WQerVPVIVMLTKLvENKKRKCDPYWPED---IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSAT
.|. |.||.|  |.   .|.|.| .| ...| .|  |||..     |.| . . ...  .. .|  | | .... . | | |. |.. ||.||| .   .
atindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpa

PLLEFITKVKEF------EARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTK
 |. ..  ||.       ... |.| .|||||||||||.. .. |...    | ......|| ..| .| .||.| .||..||||| | ...| | ||  
tlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs

TIVQYFTRLEQTNLHTKRTFLEE
..   .. |.. |  |..  .|.
sfeaklsslqernpltqklniek

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2078-2343 1.3e-73 242.8 In-house 27-293 (297) alignment
Range on Protein: 2078-2343
Range on HMM: 27-293/297.0
CFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKpkAYIATQGPLSTTVFDFWRMVWQERVPVIVMLT
 |. ..  ||  ....  || .. | .|.|| ||.||| |||.|    | |  ||.||||| |. .   .|.|| |  .|| |||.||..|.| .||||.
vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln

KLVENKKrKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPL--SATPLLEFITKVKE-FEARPSGPTIVH
.. |..| ||  ||... . |.|| .... .  .   . .|.|...|     .| |. .....|||   .   ||. ||..|. |.. |. . .|| .||
ddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPT
|.||||||| . ||||..    ||........| ..| .|...||| ||| |.|.|.|| ||.  | ...
claGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2101-2332 4.2e-73 240.8 In-house 27-266 (274) alignment
Range on Protein: 2101-2332
Range on HMM: 27-266/274.0
ENVSKNRYINIIPYDHSRVIL-DTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIET-
 . .|||| .|.| ..|||.|   .....  .|||| .. ||  . |||.||||||..||.|||||..||.|.|||||||| |....||  |.|..... 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

----YGDFTLTVVAERNYLNYTERTLTIRKAWDpeERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE---ARPSGPTIVHCSAGVGRTGTYFTIDSM
    |||. ..|.   .  .|. |.|..... .  ||.|.|. ||.|||.  | .|..||.....|.| .   . . .|..||||||.|||| . .|.  
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.    .|. ..||  |  .| .|  |||| ||| .|..|| .
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2069-2354 4.8e-72 238.0 In-house 26-311 (319) alignment
Range on Protein: 2069-2354
Range on HMM: 26-311/319.0
KEKTANGEMCFKLDYERLPDGQ--MYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVW
|..  .    .. .. |...      . . |  ..|  |||.|||...|...| |.        ||||||||.|| ... |||.||||  |. |||||.|
ksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiw

QERVPVIVMLTklvenkKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEA
. ..  ||.||      | ||  ||| .| .... | . | .  .  .|. | . . . .   . |... ||.  |||.| | ....|. .. ||. .. 
eyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

RPSGP--TIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
.  ..   .|||||||||||.| ..| ..|.  .|.|..| .||  .| .| ..||   || ||| ||||  | |.. |    .  |. .| 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels

0051299 (Phosphotyrosine protein) phosphatases II 2339-2629 6.3e-72 237.8 In-house 3-286 (288) alignment
Range on Protein: 2339-2629
Range on HMM: 3-286/288.0
TSVPTKTIVQYFTRLEqtnLHTKRTFLEEHLSALDAMSIfysdVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYI
|..... ..... .|    .. . ..|||.   |.        ... |..  ||..||||.| .|.|. | .| .  ... ..|.|| ..||.|.   .|
teisveellklvlkll...angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTV-ATESSRVIRQYSFVGWKeR
||| ||..||||||||....|..|||||...  .. ..| |||| |.   .|....    || ..|...||. ..|....  .. || .... . .|   
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.d

QKYPKSLASLLCLLDLVEAGQRdLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
. .| |. .|| .| ||   ..  |.||. |||..|| |.| |.|.   .  |. || .||..|||.||..   ||...|||....... |||
hgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPN3_pd Subfamily PTPN3 2092-2332 2.6e-71 234.8 In-house 31-273 (280) alignment
Range on Protein: 2092-2332
Range on HMM: 31-273/280.0
YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVSGYLKP----KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKC
 . ..| . ||.||||| .|.|||. ||.|.  .     |||||..|.  .      . ||||||||..|. |||.|||.... .||||| |||. . ||
laisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DPYWPEDIE--TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYF
  ||||  .  .||.|....  |..  .|  | |.....   |||.. .. |..||| |.| ... .|||...|..  .  . |..||||||.|||| . 
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

TIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
...  . .  .......|| | .|| .|  .|||..|| |. ||.|.
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

0050432 (Phosphotyrosine protein) phosphatases II 2360-2635 3.7e-71 235.3 In-house 39-305 (308) alignment
Range on Protein: 2360-2635
Range on HMM: 39-305/308.0
TKRTFLEEHLSALDAMSIfysDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcsEGQTNYVNATFLDGF--NRRDMYIATQMPLQHTVEDFWRMIYD
. ...|||   .| .. .   . .. ...  ||..||||.| .|.|. | .|     .. ..|.|| . ||.  ...  .|||| ||..||||||||...
ldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

YNSNVIVMLNEINRND-QTCSQYWPAG---DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLV
.|..|||||...  |. ..| ||||     .   .|.|.. .  || ..|...||. |.|..   .. ||..... . .|.  .. | |...|| .|.||
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg...dgesrtvthfhytnWp.dhgvPpspeilldflelv

EAGQrdlGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIY
.  .   ..||| |||..|| |.| |.|.   .  |. ||..|||.||||||..   ||...||||...... ||| . ...
rksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2097-2354 1e-70 233.5 In-house 20-275 (284) alignment
Range on Protein: 2097-2354
Range on HMM: 20-275/284.0
ATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTklvenkKRKCDPYWPEDI-
|  ..|  |||...|...|...| |.        |||||||..|| ... ||||||||  |. |||||.|. ..  ||.||      | ||  ||| .| 
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

ETYGDFTLTVVAERNYLNYTERTLTIRK-AWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSG--PTIVHCSAGVGRTGTYFTIDSMMD
.... | . | .  .  .|. | . . . .   . |... ||.  |||.| | ....|. .. ||. .. .  .  . .|||||||||||.| ..| ..|
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
.  .|.|..| .||  .| .| ..||   || ||| ||||  | |.. |    .  |. .| 
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2387-2636 5.6e-70 230.4 In-house 4-249 (250) alignment
Range on Protein: 2387-2636
Range on HMM: 4-249/250.0
GKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDEA
.|  .|..|||| | |.||. |  | .  .. ...|.||.||.|.. |...|||| |||.|.||||||.....|..||||.... ...|..||||.    
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

LIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTI
  |   ...  .|  .|...|.. ||...    ...|..||..|| | ..   |.   . | ||. |.| |.  ||.|. |.|  ||.||| |.|| . .
kyGdvtvsllskeefadytkrklklskak...kaderivrqlhfvvWPdkg.vPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYE
 .|| |  .|||. .|.|||   ..| |.||| ... .. ..| | | |.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2059-2334 6.6e-69 227.0 In-house 2-283 (290) alignment
Range on Protein: 2059-2334
Range on HMM: 2-283/290.0
VKIVELSGYVKEKTANGEMCFKLDYERLPDGQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAP--HEDYINASFVSGYLKPKAYIATQGPLS
... ... .| ...|.|.  |. ....|  |.  .| .|.. ..|  .||. ||..||  |..|   .. .   ..||||... || . |.|||||||.|
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE-DIETYGDFTLTVVAERNYLNYTERTLTIRKAWD-PEERRVQHFHYTSWPDMG-LPLSATPL
 |. |||...|||.|..|||||. .|..| ||  |||. | ..|| |..... |... .|.||.| ...     ... |.... |.|.. | ..  .| |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
| .   .|    |  .. .||||..|||.... ...  ..    |..|.|.. ....|... ..||| .|| .|.. .|. |
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2095-2332 9.3e-69 226.2 In-house 1-239 (239) alignment
Range on Protein: 2095-2332
Range on HMM: 1-239/239.0
EVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE
| | .. | .|||| ||. ||||||.|.   . || ||||||..  |   ||||||||| ....  |||||.||||  |||||| |.| .|.||  |||.
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDM
    | .. .|.     . .|  ||. . .  . ||| | ..|.| ||| |.|  || .| .  |. .     . | ..||||||||||... ||.|.  
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
. ... ......|  .|  | .|||| ||||||. |.||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2098-2332 1.1e-68 225.9 In-house 3-238 (239) alignment
Range on Protein: 2098-2332
Range on HMM: 3-238/239.0
TRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE
 .. | .|||| ||. ||||||.|.   . || ||||||..  |   ||||||||| ....  |||||.||||  |||||| |.| .|.||  |||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAR
 | .. .|.     . .|  ||. . .  . ||| | ..|.| ||| |.|  || .| .  |. .     . | ..||||||||||... ||.|.  . .
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
.. ......|  .|  | .|||| ||||||. |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPN13_pd Subfamily PTPN13 2094-2334 1.4e-68 226.2 In-house 29-269 (273) alignment
Range on Protein: 2094-2334
Range on HMM: 29-269/273.0
WEVATRQENVSKNRYINIIPYDHSRVILDTDPDaphedYINASFVSGYLKPK--AYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYW
 ||. ..|| .|||| |..|||..||.|. .       |||||..   .  .   |||.|||| .|| |||.|||. .. ||.|.|. .|..| ||. ||
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PED----IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArPSGPTIVHCSAGVGRTGTYFTI
||     .  .. ......   .. ... |.|....    | |.|.|.....||| | | ||..||.|...|....   .|| .||||||.||.||. ||
PesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtliti

DSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
| .... .|.....| . | ..| .|  .||| .||.|.|.|.|| |
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPRK_pd Subfamily PTPRK 2384-2627 4.2e-68 224.5 In-house 35-275 (314) alignment
Range on Protein: 2384-2627
Range on HMM: 35-275/314.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPA
 .| |  ||..|||. | .. |. |. |.|   . ...|.||...|...|   .|.|| |||.||.||||..||.|.  ||||.|.  .    |..||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

GDEAlIGPFVIDVSAEEREGDVIIRTFLLSNTNTvATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDlGNGPITVHCMDGVTRSGLFCAI
  |   |.. . .   | . ....|.| .....  . |  |..||. |.|| .  . |.|  .|| |.  |.. | . ..|.| |||. |  |.| |.||
dtev.ygdikvelvetellaelvvrifrveklar.gqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiai

MSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
 . .  .. || .|||.|||.||.    ||  |||| .|.||. |
divldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2385-2636 9.8e-68 223.5 In-house 40-287 (318) alignment
Range on Protein: 2385-2636
Range on HMM: 40-287/318.0
QAgKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAG
..  .. |..|||| . .. |. |  | .  .| ...|.|| ..||..|.  |||.| || .|.||||||... || ||||| .  .|  . . .|||  
ks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk

DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIM
.   .|  |.... | . .| ..|.| ...|.   .|.||..||| .  | ..   |.| |||| |.  |.. |.. |.|||.|||  || | | |.|. 
gsrsygklvvelkeevelsdyvlrefkvtrte...eeesrqvrqyhytsWpde.gvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd

STIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYE
. . ..| |. .|||. ||.||.    ||  |.|| .|.||. |.||| . . 
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2063-2340 1.1e-67 223.0 In-house 6-284 (287) alignment
Range on Protein: 2063-2340
Range on HMM: 6-284/287.0
ELSGYVKEKTANGEMCFKLDYERLPD-GQ-MYTWEVATRQENVSKNRYINIIPYDHSRVILDtdpdAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFD
... .|.. .|.|.  ||  .  | . .|      ..  ..|  |||. .|...|  ||.|       |.|||||.|. || . ||.|....|.. |. .
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarn

FWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDI-ETYGDFTLTVVAERNYLNYTERTLTIRKAW-DPEERRVQHFHYTSWPDMG-LPLSATPLLEFIT
||.......|..||||... ||....|  ||||.   ..|....... |  . .|.||.| ...   . ....|. ...|.|.. | ..  .| || .  
fWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

KVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTS
..|.   |  .. .||||..|||....  ..  .. . .|  |.|.. . ..| .. ..||| ||| ||....|| | .. | 
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

0046845 (Phosphotyrosine protein) phosphatases II 2382-2634 1.6e-67 223.2 In-house 18-279 (284) alignment
Range on Protein: 2382-2634
Range on HMM: 18-279/284.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSE-GQTNYVNATFLDGF-----NRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-Q
.|. ...  ||..||||.| .|.|. | .| .  .. . ..|.|| ..||.     ...  .||||.||..||||||||....|..|||||.|.  |. .
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

TCSQYWPAGD-EALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRD-LGNGPITVHCMDG
 |.||||  .    .|.| . .  || ..|...||. |.|...  |. || .... . .|   .. | |...|| .|.||.  ...  |.||| |||..|
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgy..tgesrtvthfhytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaG

VTRSGLFCAIMSTIGKLKSEG---NIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEI
| |.| |.|..  .  |. ||   ..||..|||.||..   || ..|||....... ||| .  .
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0040438 (Phosphotyrosine protein) phosphatases II 2361-2634 6e-67 221.5 In-house 17-281 (317) alignment
Range on Protein: 2361-2634
Range on HMM: 17-281/317.0
KRTFLEEHLSALDAmsifY-SdvSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYN
.. .|||.   |.       .  ... ..  ||..|||||| .|.|  | .|    .   ..|.|| . ||.|... .|||| ||..||||||||.....
ftalleefedllsl....kld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

SNVIVMLNEINRN-DQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQR
..|||||.|   . ...| |||| |..  .|.|.. .  || ......||. ....    .. || .... . ||   .. |.|. .|| .|..|.. ..
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWp.dhgvppspdllldfleavreale

dLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEI
  ..||. |||..|| |.| |.|.   .  |. ||..||..|||.||.. . .|...||| ...|...|||   . 
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt

0047943 (Phosphotyrosine protein) phosphatases II 2359-2629 1.4e-66 220.1 In-house 9-272 (273) alignment
Range on Protein: 2359-2629
Range on HMM: 9-272/273.0
HTKRTFLEEHLSALDAMSifysDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDY
  ....|||.   |.       ........  ||..||||.| .|.|. | .|    ..| ..|.|| ..||.|.   .||||.||..||||||||....
lgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NSNVIVMLNEINRNDQ-TCSQYWPAGD---EALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVE
|..|||||.|.  ... .| ||||      .   |.| . .  || ..|...||. |.|..   |. ||..... . ||   .. | ||.||| ...||.
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...tgesrtvthfhytgwp.dhgvppslesllefielvr

AGQRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
  .. | .|||. |||..|| |.| |.|.   .  |. ||..||. |||.||..   ||...|||....... |||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2083-2332 2.4e-66 218.5 In-house 1-262 (270) alignment
Range on Protein: 2083-2332
Range on HMM: 1-262/270.0
YERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVE
...|. ... . .. .   .   ||| .|.|  ..||.|..  . ..  |||| .| |.  ..|.|||..||| ||...||||.|.|.|. |||.|.|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

NKKRKCDPYWPEDIET-----YGDFTLTVVAERNYLNYTERTLTIRkaWDPEERRVQHFHYTSWPDMGLPLSAT------PLLEFITKVKEFEARP--SG
. ..||. |||.. ..     .|. . ....|..   |  . |...   . ||||. ||.|..||| | | ..        ||. . .|...| .   ..
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
|..||||||||||||  ..| .. .  ......||  . ..| .|...||.|||| |.|.|..|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_CG7180_pd Subfamily CG7180 2076-2338 2.9e-66 218.1 In-house 16-294 (296) alignment
Range on Protein: 2076-2338
Range on HMM: 16-294/296.0
EMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVM
.. .|| ..  |  .. .   . |.||  |||.....|||. ||.|..     ..|||||..| ..||.|.|| |..|   || .|||.|..| .  .|.
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LTKLVENKKrKCDPYWPED-IETYGDFTLTVVAERNYLNYTERTLTIRKA----------WDPEERRVQHFHYTSWPD-MGLPLSATPLLEFITKVKEFE
|||  . .| ..  |||..  | ||.. . .| |..| | . ||. . |            . |.| |..|..| |.    .|||.. |.|.. .|. . 
Ltktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

ARP-----SGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
 .       ||..|..| |..|.| |..||  ...  .|....| ..| ..| .| ..|.. |.| .||. ||| .||. 
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2382-2633 7e-66 217.5 In-house 38-287 (319) alignment
Range on Protein: 2382-2633
Range on HMM: 38-287/319.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYW
....  .  ||..||||.. .. |. |  |..     ...|.||.|.||...|. .|||| ||..|.||||||.....| ..|||.... .    ...||
dtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

PAGDEALIGPFVIDVSAEEREGDVIIRTFLLsNTNTVATESsRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFC
|  .    | .....  ||.  |.||| . | |...   |. | . .. .  | .  . |... ||| ||  ..  ..   .|||.||| .|| | | |.
peenfeeyGrlivtleeeeeledyiirklkl.nkkssevet.RevkhfqyteWpdh.dvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi

AIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
..  .. ..| || .|||. |..||     ||  .||| .|.....|.. . .
vldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2371-2635 1e-65 216.5 In-house 25-289 (290) alignment
Range on Protein: 2371-2635
Range on HMM: 25-289/290.0
ALDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLM--TGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE
   ..  . |. ... | .|.|...||. . .. | .|  |   .|  . . .|.||....|.. .  ||||| |...|. |||..|.. .. .|||| .
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltn

INRNDQ-TCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVatESSRVIRQYSFVGWKERQKYPKSLASLLCLlDLVEAGQRDLGNGPITV
|. ... .| ||||. | . .|.| | .. ||   . |.|.. . |.|.   .... . || .  |..  | ..  ..|| .   ..  ||  ||..| |
iieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvi.eemyktqrkrgntsivv

HCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIY
|| |.|.||..|||.. || | |.|| ||||. .|..| .   .| ...|| .|...| .|| | | |
HCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2377-2638 1e-65 216.9 In-house 31-295 (305) alignment
Range on Protein: 2377-2638
Range on HMM: 31-295/305.0
IFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQT
.   . |.. ||...|..|||. ....||. |  | .  |.....|.||...||..|.. ||..| ||..||.||||.|...  ..|||| ..  . .. 
lyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdk

CSQYWPAGDEA--LIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGV
| ||||        .|.|.. .. |.   | |.| . .|. ..   . ||.. || .  | . .  |.. .||| |.. |.  |.   . |..||| .||
CrqYWpesktekkefgefsvelksektasdyieRklkisiede..dkesrtvlqyqltdWPd.hGvpqfatsllslikrvqkdqkkdkgvpllVhCsagv

TRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE---IYENF
 |.| |.|.   . .|| |. .|||. .|.||.    || . .|| ..||.. |.. . .   | .|.
gRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl

0036941 (Phosphotyrosine protein) phosphatases II 2379-2633 1.3e-65 216.9 In-house 26-281 (297) alignment
Range on Protein: 2379-2633
Range on HMM: 26-281/297.0
YSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCS
. . |. .... || .||||.| .|.|. | .|    ... ..|.|| ..||...   .|||| ||..||||||||....|..|||||.|    . ..| 
lllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPAG--DEALIGPFVIDVSAEER--EGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDL-GNGPITVHCMDG
||||    ..   |.|.. .  .|   ..|...||. ...|    .. ||..... . || .  . | | |||| ...||.  .. | ..||. |||..|
qywpleegesltygdftvtllsvevvllddytlrtlevtdt...gngesrtvthfhytgwpdh.gvpespaslldfielvrkvlkllpsggpvlVHCsaG

VTRSGLFCAIMSTIGKLK---SEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
| ||| |.|.   .  |.    ||..|.. ||||||..   .|...|||....... |.| . .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0039614 (Phosphotyrosine protein) phosphatases II 2355-2629 1.7e-65 216.8 In-house 24-289 (297) alignment
Range on Protein: 2355-2629
Range on HMM: 24-289/297.0
QTNLHTKRTFLEEHLSALDAMSIfysDvsMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSE-GQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFW
. .  ...|.|...   |  . .   |  .  ... || .||||.| .|.|  | .| .  .    ..|.|| ..||...  . .|||| ||..||||||
llekansktllllefeellslkp...d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDEaLIGPFVIDVSAEEREGDVIIRTFLLSNtntvaTESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDL
||.......|||||.. . ....| ||||   .   |.|.. .  .| ......||. ..|     .. || .... ..||    . | ||..|| .|.|
rmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.....ngesrtvthfqytgwp.dhgvppslellleflel

VEAGQRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|.  .. | ..||. |||..|| |.| |.|.   .  |..||..||..|||.||.. . .|....|| ...|...|.|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_PTPN1_pd Subfamily PTPN1 2090-2335 2.5e-65 215.1 In-house 20-272 (290) alignment
Range on Protein: 2090-2335
Range on HMM: 20-272/290.0
QMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDP
. .. ..| ..|| ..||| .. ||||||..|. .      ||||||.|      . || |||||. ||  ||.|||...   .||| |.||... ||  
sdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPEDIE----TYG--DFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE--ARPSGPTIVHCSAGVGRT
|||.. |    ..    .......| .. .|| |.| . .    | | . |||||.|||.|.| | . .|.|. ||.|    ..  ||...|||||.||.
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GTYFTIDSMM-DMSAREQ--QINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
||.  .|...  . ....   ... . .  .|  |. ..||..|  | | |.||   
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2362-2626 5.1e-65 214.4 In-house 20-276 (288) alignment
Range on Protein: 2362-2626
Range on HMM: 20-276/288.0
RTFLEEHLSALDAMSifySDVSMQAGKSSENHHKNRYPDNIPLDkYRPYLMTGCSE-GQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNS
|| ..|.  .| |.    .. | .||. ..|..||||.. .|.| ...  ...  |  ...|.||...|| ...  ||||| ||..||.|||...|....
rtgfseeynsLaale...ktksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

NVIVMLNEI-NRNDQTCSQYWPAGDE-ALIGPFVIDVSAEEREGDVIIRTFLLSntntvATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQR
. ||||.|. ......| .|||..|.  . | . . .  .. ..|.. |..||       ... . | || . .| . .  |.| | || ||. |.  . 
stivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhg.vPeskapllellrqvkvanq

DLgNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
.   |||.|||..|| |.| | |.   | ....|  |||. .|.||||    .|  ..|| .|..|. 
ad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2077-2354 1.3e-64 213.0 In-house 20-256 (392) alignment
Range on Protein: 2077-2354
Range on HMM: 20-256/392.0
MCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVML
  |  ..  ||. ..|   || .. |. |||| ||.||| .||.|.   | |..||.|||.. ..   |||||.||| .... ||||||.||.|  |.|.
alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TKLVENKkrkcdpywpedietygdftltvvaernylnytertltirkaWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSA
||| |                                              . | |  ||.| ||| ..|  .. ||.|| .||    . . | |.||||
tklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTKTIVQYFTRLE
||||||   .|||..  . . . ..|..||  .| ||  |||| ||| ||| |.|| ||   | .|   .... . |.
gvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

subfamily_Ptp69D_pd Subfamily Ptp69D 2352-2630 1.3e-63 210.0 In-house 12-287 (307) alignment
Range on Protein: 2352-2630
Range on HMM: 12-287/307.0
RLEQTNLHTKRTFLEEHlSALDAMsifYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDF
 |.. . .|.  ...|.   | |     .| | ....  ||  ||||.| .. ||.|  | .   . ...|.|| |. |.. .  .|| | |.. |..||
alksrkrdtdfglakey.ekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDf

WRMIYDYNSNVIVMLNEIN-RNDQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVA--TESSRVIRQYSFVGWKeRQKYPKSLASLLC
|||| . ....|||| ...  |.. |..|||  ||   |  ....  ||. .| |||.. .|...  .   | || . ||.. |||   | |..  .|| 
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllk

LLDLVEAGQRDLgNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|.. |.  ..   ..||.|||  || |||.| |. | . .|| | ..|.|. ||.||.    .| | ||| ...  . .|  
lieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2101-2332 1.6e-63 209.1 In-house 2-237 (237) alignment
Range on Protein: 2101-2332
Range on HMM: 2-237/237.0
ENVSKNRYINIIPYDHSRVILDTDPDAphEDYINASFVSGYL-KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE--DIET
||  |||| ||. ||||||.|     .   |||||... |.   || |||.|||| ..  |||.|||||.  |||||| |.|... ||  |||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDFTLTVVAERNYLNYTERTLTIRKAWDPEERR-VQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR--PSGPTIVHCSAGVGRTGTYFTIDSMMDMS
|| .|...  . .. .|| |.|.. | .  .| | .. ...||||| |.|  .. || |  .. .       ||| |.|||||||||| .. ||.|.  .
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
  .. ... ..|| .   |  ..|| .|||||....||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

DSPc_SM00195 2383-2629 1.7e-63 209.8 In-house 17-262 (263) alignment
Range on Protein: 2383-2629
Range on HMM: 17-262/263.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP
... .. ..|..|||| . .| |. |  | .  .. ...|.|| ...| |..  |||||.||..||||||||... ....||||.| .  . ..|..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

AG--DEALIGPFVIDVSAEEREG-DVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLgNGPITVHCMDGVTRSGL
    ..  .| . . .  .| .  ..|.||. |.....   | .| ..|| . .|... ..|.|  |.| ||  |.  ..   .||| ||| .|| |.| 
eesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgt

FCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|..| . . ||..| ..|.|. ||.|||   .|| ..||||.|.... ||.
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 2383-2629 1.7e-63 209.8 In-house 17-262 (263) alignment
Range on Protein: 2383-2629
Range on HMM: 17-262/263.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP
... .. ..|..|||| . .| |. |  | .  .. ...|.|| ...| |..  |||||.||..||||||||... ....||||.| .  . ..|..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

AG--DEALIGPFVIDVSAEEREG-DVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLgNGPITVHCMDGVTRSGL
    ..  .| . . .  .| .  ..|.||. |.....   | .| ..|| . .|... ..|.|  |.| ||  |.  ..   .||| ||| .|| |.| 
eesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgt

FCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|..| . . ||..| ..|.|. ||.|||   .|| ..||||.|.... ||.
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0043336 (Phosphotyrosine protein) phosphatases II 2348-2629 1.9e-63 209.9 In-house 6-277 (278) alignment
Range on Protein: 2348-2629
Range on HMM: 6-277/278.0
QYFTRLEQTNLHTKRTFLEEHLSALDAMSifysdVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHT
..  .|.. .|  |...|.|. . |.         ..  ... ||..||||.| .|.|  | .|    ..  ..|.|| ..||.|. . .|||| ||..|
dllkallelllnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPaGDEALIGPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKeRQKYPKSLASL
|||||||........||||.|   .. ..| |||| |.   .|.|.. .  || ..|...||. ..|     .  || ...| ..||   .. | ||..|
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwp.dhgvpeslsll

LCLLDLVEAGQRdLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
| .|  |   ..   |||. |||..|| |.|.|.|.   .  |..||..|...|||.||.. . .|....|| .......|||
ldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 2382-2629 6.6e-63 207.6 In-house 48-295 (330) alignment
Range on Protein: 2382-2629
Range on HMM: 48-295/330.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN-RNDQTCSQYW
 .... .  ||..|||... .| |  | .| .   . ...|.||.|.||....| .||.| |...|||||||||....|  |||| |.. |... | |||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTV-ATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNgPITVHCMDGVTRSGLF
|       |   . |  |.   |. .| ||. . .     ..||..||. | .| .    |     .| ||  |.. ..  .. ||.|||  || |.| |
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtf

CAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
... . . ..|.|. .|||..||.||.   .|| ..||| .|. |..|| 
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN23_pd Subfamily PTPN23 2094-2332 1.5e-62 206.1 In-house 35-278 (288) alignment
Range on Protein: 2094-2332
Range on HMM: 35-278/288.0
WEVATRQENVSKNRYINIIPYDHSRVILDtdpdAPHEDYINASFVSGYLK-PKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP
  .|  . ...|||. .|.||||.|| |.      ..|||||||| .       .||||.|| .|. |||.||......|||||..  | .| |.| |||
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

EDIE---TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKE----FEARPSGPTIVHCSAGVGRTGTYF
|| .   ..||...|.  .|.  .. ||.|...     . . |.| ..||||..|.| |   ||.|. .|..     . .   | .|||||||||||.. 
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

TIDS-MMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
 . . . ......  ..... | |.|..|  |||. ||. | ||| ||
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2383-2638 1.6e-62 206.1 In-house 38-287 (287) alignment
Range on Protein: 2383-2638
Range on HMM: 38-287/287.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWP
..  . .|.|..|||. . .. |.||  |     . . .|.||.|.||.. .  .|... |. .|. .||..| | | ..|||| . . ||.  | ||||
evthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp

AGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEaGQRDLGNGPITVHCMDGVTRSGLFCA
 ..  ..|.. | .  ||.. ..|.|.. . |.|   ... . ..|| .  |... | ..  ..|| . . .   ||  ||..| ||| |.| ||..|||
eeksvvlGeyniellneevnagyierklevknknk..agdkqqvkqyqitnWdstgkvtepqtillvieemyk.tqrkrgntsivvhCsdtvGrsamfca

IMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYENF
.  || | | || ||||  .|. |     .|   ||| .| |.| ||| | |.| .|
aattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

0045450 (Phosphotyrosine protein) phosphatases II 2357-2629 2.9e-62 206.5 In-house 21-304 (307) alignment
Range on Protein: 2357-2629
Range on HMM: 21-304/307.0
NLHTKRTFLEEHLSALDAMSIFYsDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSE-GQTNYVNATFL--------DGFNRRDMYIATQMPLQHT
.| . .| |...   |  . .|.   .. .... ||..||||.| .|.|  | .|..  .. . ..|.||..         ||... . .|||| ||..|
llldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEA-LIGPFVIDVSAEEREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWKeRQKYPKSLAS
|||||||.......|||||.|   ...  | ||||  .|   .|.|.. .  || ......||. ....    |. || .... . ||   .. |.|...
vedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwp.dhgvppsfee

LLCLLDLVEAGQRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGN---IDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|| ....|.. ...| ..||. |||..|| |.| |.|.   .  |..||    .|...|||.||.. . .|...||| .......|.|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2385-2632 3.3e-61 202.2 In-house 41-291 (325) alignment
Range on Protein: 2385-2632
Range on HMM: 41-291/325.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAG-
..    ||  |||... ..||| |. | |   .....|.||..|  . ..|...|.|.|| .|..|.||...|... |.|.|||.. ... |..|||   
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkem

-DEALIGPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWK--ERQKYPKSLASLLCLLDLVEAGQRD--LGNGPITVHCMDGVTRSGL
 .    |.. . . . |   | . | . . .   |    .| ..|. . .|.    ||.| .|.|.| |.. |.   .    . .|| |||..|| |.| 
gksktfGglevklrtieeisdyvhrvldvkq...vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASC
| .. | . |.  | ..|.|  ||||||    || . .||  |.. . |.. | 
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg

0040439 (Phosphotyrosine protein) phosphatases II 2387-2629 6.5e-61 201.4 In-house 6-246 (249) alignment
Range on Protein: 2387-2629
Range on HMM: 6-246/249.0
GKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWPAGDE
..  ||..|||||| .|.|  |..|    .   ..|.|| ..||... . .|||| ||..||||||||.......|||||..  ..  ..| |||| |..
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

ALIGPFVIDVSAEEREGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRDL-GNGPITVHCMDGVTRSGLFCAIMS
  .| |.. .  .| ..|...||. |.|.    . .|| .... ...|   .. |.|...|| ....|.  ...|  .||. |||..|| |.|.|.|.  
leygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 .  |. |...|...|||.||.. . .|...||| .......|.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

Y_phosphatase Protein-tyrosine phosphatase 2392-2625 1.4e-60 200.0 Pfam-A 1-233 (235) alignment
Range on Protein: 2392-2625
Range on HMM: 1-233/235.0
NHHKNRYPDNIPLDKYRPYLmtGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP--AGDEALI
|..||||.| .| || |  |    |||...|.|| ...|...  ..||||.||..|.||||||.......|||||.. .  ....|.||||   ...   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPFVIDVS-AEE-REGDVIIRTFLLSNTNTVAteSSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQrDLGNGPITVHCMDGVTRSGLFCAIMSTI
| . . .   |.  | ....|.. |.....     .| ..|. . .|.  .. |.|  ||| |.. ||  . .  .||..|||..|| |.| |.|..  .
gdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 .|..|...||...||.|||.   || |.||| ......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 2392-2625 1.4e-60 200.0 In-house 1-233 (235) alignment
Range on Protein: 2392-2625
Range on HMM: 1-233/235.0
NHHKNRYPDNIPLDKYRPYLmtGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWP--AGDEALI
|..||||.| .| || |  |    |||...|.|| ...|...  ..||||.||..|.||||||.......|||||.. .  ....|.||||   ...   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPFVIDVS-AEE-REGDVIIRTFLLSNTNTVAteSSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQrDLGNGPITVHCMDGVTRSGLFCAIMSTI
| . . .   |.  | ....|.. |.....     .| ..|. . .|.  .. |.|  ||| |.. ||  . .  .||..|||..|| |.| |.|..  .
gdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 .|..|...||...||.|||.   || |.||| ......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPRN_pd Subfamily PTPRN 2092-2332 5.2e-60 197.7 In-house 46-290 (297) alignment
Range on Protein: 2092-2332
Range on HMM: 46-290/297.0
YTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGY-LKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
 | ||| ...||.|||. ...||||||| |... .| ..||||||..     .  |||||||||..|| |||.|||.. | |||.||.| |.  ..|. |
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPED-IETYGDFTLTVVAERNYL-NYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKE-FEARpSGPTIVHCSAGVGRTGTYFTI
||..  |.|. . . .|.|  .  .|  |.. ..     | | |  ||. |||..| | || .||||  ||   .  | | | .||||.|.||||.|  |
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr.scpivvhcsdGaGrtGvyili

DSMMD-MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
| ... .    ..|..   .  .| .| ..|.| .|. |.. |. |
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

0042113 (Phosphotyrosine protein) phosphatases II 2388-2629 2.5e-59 196.0 In-house 5-243 (245) alignment
Range on Protein: 2388-2629
Range on HMM: 5-243/245.0
KSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGDEA
.  ||..||||.| .|.|  | .|.   ..  ..|.|| . ||... . .|||| ||..||||||||........||||.|   .. ..| |||| |.. 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

LIGPFVIDVSAEEREGDVIIRTFLLSNTntvATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTI
 .| |.. .  || ..|...||. ..|.    .  || ...| ...|   .. | .|..|| .|..|.  ... .|||. |||..|| |.|.|.|.   .
tygdftvtllseehlddytvrtlevtnl...gddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
  |..|.......|||.||.. . .|....|| .......|.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2097-2344 4.3e-59 195.1 In-house 43-289 (439) alignment
Range on Protein: 2097-2344
Range on HMM: 43-289/439.0
ATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKrkcdpYWPEDIE
|... . .|||| .. ..||.||.|.  |  ||  |||| .. || ..| |||||||   |. ||||.|.....  |||||.|||  |     ||| | |
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae

TY-GDFTLTVVAERNYLNYTERTLTIRKAWD--PEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEF-EARPSGPTIVHCSAGVGRTGTYFTIDSMMD
.. || .. |  . .  ||. | . . .  |    || | .|||..|||  .|  |. .|.|.  ..   . .  || .||||||||||||  ..|  ..
vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSVPTK
    |.....   |  .| .| .|||.  ||||||.|.|| .  | ..|   
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtid

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2384-2629 3e-58 192.2 In-house 41-279 (315) alignment
Range on Protein: 2384-2629
Range on HMM: 41-279/315.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPA
..  | .||..|||| . |. || |..|     . ...||||.|.||.|....|||.| |.  .|.||||......   ||||...  ...  . .||| 
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

GdEALIGPFVIDVSAEEREGDVIIRTFllsntNTVATESSRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRDLGnGPITVHCMDGVTRSGLFCAI
  . . |.. .    || . .. .||.      .|  .  | . |. .  |    . ||.  .|. |   |   . .   |.| ||| .|| |.| |...
k.kviyGkitvtrkseevnteytvrtl.....svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitl

MSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 . . ... |  |||.......|.   .|| . ||| .|.|.. | .
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

0045098 (Phosphotyrosine protein) phosphatases II 2384-2629 3e-58 192.7 In-house 25-272 (278) alignment
Range on Protein: 2384-2629
Range on HMM: 25-272/278.0
MQAGKSSENHHKNRYPDNIPLDKYRPYlmtgcsegqtNYVNATFLDGFnrRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPA
.  .   .| .||||.| .|.|  | .          .|.||...||.  .. .|||| ||..||.|||||.......|||||.|   .. . | |||| 
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTV-ATESSRVIRQYSFVGWKERqKYPKSL--ASLLCLLDLVEAGQR------------DLGNGPITV
|.   .|.|.. .  ||. .|...||.|. |...  ..  || .... ...| .    | .   .|.| ||. ... ..            . ..||. |
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllsslllldsggpvlV

HCMDGVTRSGLFCAIMSTIGKLksEGNIDVFHAVKKLRKCSGR-MVPSEEQYLYIHDVVREYL
||. || |.| ..|..  .  |  ||..|...|||.||.. .  .|...||| .......|.|
HCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_PTPRG_pd Subfamily PTPRG 2376-2633 3.4e-58 192.2 In-house 31-291 (563) alignment
Range on Protein: 2376-2633
Range on HMM: 31-291/563.0
SIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCS-EGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRND
 .  .|. ... .  ||..|||| . .. |. |  |      ... .|.|| ..||... . .|||| ||..|..||||||.. |...|||. .  .|. 
etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergr

QTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVATES---SRVIRQYSFVGWKERQKyPKSLASLLCLLDLVEAGQRDlGNGPITVHCM
. | .|||. .   .| . .   .||.     .||. . |..  ....    ...||| .  | . .  |.. .  |      .| ...   |||.||| 
rkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv.PehslpvLifvkkssaanka.eaGPivvHcs

DGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
 ||.|.| .... . . ....|  ..||. .|..|     .| .||||...||.. | .|| |
aGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2094-2341 5.9e-58 191.0 In-house 25-273 (283) alignment
Range on Protein: 2094-2341
Range on HMM: 25-273/283.0
WEVATRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVS---GYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
 ..|. .||  |||. .|.|.|  || |....     |||||.|.     | . | ||..|.||  || |||.||..|..  ||||||| |... ||  |
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPED-IETYGDFTLTVVAERNYLNYTERTLTIRKA-WDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTID
||..  | ||.||.|.  |     .. . |..|.     ..  . |. .  | ..|       |. |   .      . || .||||.|.|||... .. 
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaas

SMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSV
. ..    |  ..|   |  || .|. .||| .|| ...|. ||  ||| | .
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi

subfamily_PTPN14_pd Subfamily PTPN14 2081-2333 8e-58 190.8 In-house 27-295 (300) alignment
Range on Protein: 2081-2333
Range on HMM: 27-295/300.0
LDYERLPDGQMY-TWEVATRQENVSKNRYINIIPYDHSRVILDTDPDApHEDYINASFVSGYL--KPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLT
 .|||.|  ..  . ..|. .||..|||. ...||...|| | .  .. ...||||| ..  .  | . ||..|||| .|| |||.|||.. | .|||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KLVENKKRKCDPYWPED-----IETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR-------
.  |. | |.  |.|..       ..| | .|    ..   .. ..|...     ||| | |. || ||| |.|   .. |... .|.    .       
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

--PSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLEC
   . | .|||||||||||   . | ..     ...|..   . |.|..|  .|||  || |.|..|.. 
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2350-2633 1.3e-57 190.2 In-house 15-288 (297) alignment
Range on Protein: 2350-2633
Range on HMM: 15-288/297.0
FTRLEQTNLHTKrTFLEEHLSALDAMsIFYSDVSmqagKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRrdMYIATQMPLQHTVE
|. | |.| ||.  | || |  . |. |. . |.    .   | .|.|| . .| |. |  |    .. . .|||| |. |..    .|.|||| . ||.
fatlvqknrhtd.vfseeflclpean.iqpqtva....ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatva

DFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERQKYP-KSLASLLC
|||.|..|.. ..|||||. |..|. | .||.    .  |  .. ... ..    | |.. ... ..    . ||..|| || | ...    .| .||| 
dfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgka...karrvvkqyqfveWPdkaverkdsassllk

LLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCE
|.. |.    .  .||. |||. || | |....| | . . | | ..|.|  |||||.    .|  .||| ... .| |.| | .
lisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_CG7180_pd Subfamily CG7180 2386-2629 1.5e-57 189.5 In-house 36-290 (296) alignment
Range on Protein: 2386-2629
Range on HMM: 36-290/296.0
AGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWPAGDE
.|  .||  |||... .| |. |..| .   | ...|.||.. |.| .   || |..| ..||..|||..|| ... .|.| .     . . .|||   .
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnksk

ALIGPFVIDVSAEEREGDVIIRTFLLSNT-------NTVATESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEAGQRDL----GNGPITVHCMDGVT
.  |......  |.   .. |||| |  .       ..  .   |..... .  |.  .| | | ..|. |.  |.  ..       .||. |.. ||..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
||| ..||  .. ... |...|||.|||.||.   ..| . |.| || ||. |..
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2089-2331 1.6e-57 189.5 In-house 25-274 (287) alignment
Range on Protein: 2089-2331
Range on HMM: 25-274/287.0
GQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPhEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCD
.  .|.  |.   .|.|||| ...|.|..||.| ....    ||||| .|..| . .|.||.|||...|| ||||.|...|. .....|. ||. . || 
sstatfkaaeelaavkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

PYWPEDIE--TYGDFTLTVVAERNY-LNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKE-----FEARPSGPTIVHCSAGVGR
 ||||       | ......   .   .|. |.| . ..   | | |. ... |||| .|. .|  |. |. .||.      .|   || .||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
.|.....  ....     ...|   | |.| .|  .||.. |. ..|||| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2385-2630 6.9e-57 187.7 In-house 37-278 (315) alignment
Range on Protein: 2385-2630
Range on HMM: 37-278/315.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPA-
.... ..|..|||| ...|||. |  |     . . .|.||... ...    |||.|.||. .|.|||||.....   |||... ...|.  | ||||  
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTntvatESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGqRDLGNGPITVHCMDGVTRSGLFCA
 .| .  | . ...   |  .| ..| . . ..     |.|| . |. | .| ..   .| ..||| |.  | |  ..  . .. |||. || |.|....
kadsvefGsikvellsleadtdgvarklvtrks.....eesrtvtqfqftewPdkG.vdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvis

IMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|.. . ..| .  .|||. ||.||.    .| .||.| .|.|.|.|.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPRB_pd Subfamily PTPRB 2363-2631 3e-55 182.3 In-house 26-287 (293) alignment
Range on Protein: 2363-2631
Range on HMM: 26-287/293.0
TFLEEHlsalDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNV
 | ||.    . .. . .| ...| ....|. |||| . .| |. |  |..  .| ...|.|| ...|.| .  .|||| || .||.|||||... .|..
rfseey....eelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLNEINRND-QTCSQYWPAG-DEALIGPFVIDVSAEEREGDVIIRTFLLSNtntvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAG-QRD
|||| ..  .  . | .||||  .. | |   ... |||.  | .||......     ....| .||| |. | .    |.. ..|| ..  |.   ...
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdh.gvPektktlldfvrtvreaiekt

LGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLAS
  ..||.|||  || |.| | |.   . ....|  .|.|  | .||.    .| .|.||..||..| ..| .
askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0041856 (Phosphotyrosine protein) phosphatases II 2102-2341 6.3e-55 180.9 In-house 1-178 (182) alignment
Range on Protein: 2102-2341
Range on HMM: 1-178/182.0
NVSKNRYINIIPYDHSRvildtdpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTklvenkkrkCDPYWPedietygdf
|..|||| .|.||||||          . |||||... |.|... .|||||||  || ||.||...... .||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

tltvvaernylnytertltirkawDPEERRVQHFHYTSWPDMGLPLsATPLLEFITKVKEfearPSGPTIVHCSAGVGRTGTYFTIDSMMDMsareqQIN
                        . .|| . ...|..|||.| |     ||.|| .|.|    ..||..||||||||||||.  .. |. .     ...
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

VLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGYTSV
. . |  .| .| .||.||.||.|.. |||| ||...| .
leeavklvrsrRpgmvitpnqyfflqlallellllkktrp

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2367-2630 8.9e-55 180.7 In-house 22-277 (515) alignment
Range on Protein: 2367-2630
Range on HMM: 22-277/515.0
EHLSALDAMSIFYSDVSmqagKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML
| .  |    |.   |.    .   |..|||| ...|.|. |  |     . . .|.||... .|.    |||.|.|.. .|.||||.....|   |.|.
eefhdlpgpniypqtva....qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

NEINRNDQT-CSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLsntntVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRDLGnG
.. ...|.  |..|||   ||    | . ... . |  .. |.|.. .     .  . || . |. | .| ..   ||   ||| |.  | | .  .   
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.....lkgddsrtvtqfhfteWPdkG.vpkhtssllklikevkadhgqyt.h

PITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|. .||. || | |....|.| . . |    .|||. |...|.    .|  .||| .|...|.|.| 
pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

0037934 (Phosphotyrosine protein) phosphatases II 2386-2629 1.1e-54 180.9 In-house 4-242 (243) alignment
Range on Protein: 2386-2629
Range on HMM: 4-242/243.0
AGKSSENHHKNRYPDNIPLDKYRPYLmtgcsEGqTNYVNATFLDGFNRrdmYIATQMPLQHTVED----FWRMIYDYNSNVIVMLNEIN-RNDQTCSQYW
 ... ||..||||.| .|.|  | .|     || ..|.|| . ....|   .||||.||..||||    ||||.......|||||.|   .. . | |||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PagDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVATEssRVIRQYSFVGWKeRQKYPKSLASLLCLLDLVEAGQRD-------LGNGPITVHCMDGV
|  .|  .|.|.. .  ||  .|...||.||.|...   .  | ...| ...|   .. | | ..|| .|| | . ...        ..||. |||. ||
p..gevtygdftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

TRSGLFCAIMSTIGKLksegNIDVFHAVKKLRKCSGR-MVPSEEQYLYIHDVVREYL
 |.|...|.   . .|    ..|...|||.||.. .  .|....|| .......|.|
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

0051429 (Phosphotyrosine protein) phosphatases II 2128-2355 7.7e-54 178.4 In-house 2-245 (272) alignment
Range on Protein: 2128-2355
Range on HMM: 2-245/272.0
PHEDYINASFVSGYLK---PKAYIATQGPLSTTVFDFWRMvWQERVPVIVMLTKLVENKKRKCDPYWP-------------EDIETYGDFTLTVVAERNY
| ..||||..|.|| .   |.......|||  |. ||||. ..... .||.|....| .. |||.|||             .   .||....|.. | ..
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

LNYTERTLTIRKA-WDPEERRVQHFHYTSWPDMGLPLSAtpLLEFITKVKEfearpSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQIN--------V
|.|. |.|....     | |.| |.|||.|||.| | .|  |||..  . .     .|| .||||||..||||.  .. ..    .|. ..        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LDFVYRMRTKRVKMVQTPEQYVFIYEALLEClLCGYTSVPTKTIVQYFTRLEQ
...| ..| .| ..|||.|||.|.||||||  |....||.  .. .... ...
eeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide

subfamily_PTPN12_pd Subfamily PTPN12 2381-2630 6.3e-53 174.5 In-house 29-278 (290) alignment
Range on Protein: 2381-2630
Range on HMM: 29-278/290.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQY
 .| .||...|| .|||| | .| || |  | .  .| . .|.|| |. | . . .|||.| || .|..||||||...| ...||. .|.. . . | .|
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPAGDE-AL-IGPFVIDVSAEEREG-DVIIRTFLLSNTntvatESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRdLGNGPITVHCMDGVTRS
||   | .| .|.| .....|..   | .|||. . .      . ||...|. .  | ...  |.|  ||| |..||.  |.   . |. |||  || | 
WpeegeeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhg.vPssaksllelielvrelqe.sedaPlvvhCsaGvGrt

GLFCAIMSTIGKLKSEG---NIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
|  .||  .   ||.|    ..|||. | .|||    .| ..||| ...  | |.. 
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2074-2336 4.2e-52 171.7 In-house 12-295 (301) alignment
Range on Protein: 2074-2336
Range on HMM: 12-295/301.0
NGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPD--APHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVP
. .  |. .|..| .|.  . .| ...||   ||. || .||. |.|| . |.    ...|||||...|| . |..||.|||.  |. ||||..|||.. 
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

VIVMLTKLVENKKRKCDPYWPE---DIETYGDFTLTVVAERNYLNYTERTLT-----------------IRKAWdpEERRVQHFHYTSWPDMGLPLSATP
 |||.|.| |..| ||  |||.   . |..| || |.| | .| ... | |.                 ....   . . |  .. |.||. |.      
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt

LLEFITKVKEFEARP-SGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
 |. | .|   . ..  || .||||..|.|.|.| ...  ..   .|  ..| . . ..| .. ..|.| |||..||... . | .
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2389-2627 7.5e-52 171.6 In-house 58-289 (319) alignment
Range on Protein: 2389-2627
Range on HMM: 58-289/319.0
SSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNeinrnDQTCSQYWPAGDEALI
  .|  |||. . .. || .  |     |  ..|.||.|..|. |.|.|||.| ||. |..||||||..||.  ||.|       . ||||||   .   
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivike

GPFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLV-EAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIG
. | ..|.. |   . ..| . ||.      .  | |.|. | || .    |.. . |..|.. |    ..  .. .| |||  || |.| . ..   . 
erfkvkvdsveetaeyvvrdielsedgk..ekdirkitqfhflGwpdvG.vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

KLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
..| |  .||.. |. ||.   ..| .  || .|.  . |
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2390-2627 2e-51 170.2 In-house 23-253 (284) alignment
Range on Protein: 2390-2627
Range on HMM: 23-253/284.0
SENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNeinrnDQTCSQYWPAGDEALIG
 .|  |||. . .. || .  |     |  ..|.||.|. |. |.|.||||| ||. |..||||||..||.  ||.|      .. ||||||   .   .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikee

PFVIDVSAEEREGDVIIRTFLLSNTNTvaTESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLV-EAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGK
 | ..|.. |   . ..| . ||.      .  | |||. | || .    |.. . |..|.. |    ..  .. .| |||  || |.| . ..   . .
rfkvkvdsveeseeyvvrdielsedgk..ekdirkirqfhflgwpdvg.vpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
.| |  .||.. |..||.   ..| .  || .|.  . |
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2095-2332 4e-51 168.4 In-house 49-281 (290) alignment
Range on Protein: 2095-2332
Range on HMM: 49-281/290.0
EVATRQENVSKNRYINIIPYDHSRVILDtdpDAPHEDYINASFVSGyLKPkAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED
..  .. .. |||| ...  | .||||.   |  . ||. | .| | ||.  .| |||.|  ||.|.|||| ||.| .|||| .|.|. | ||..|.|| 
kifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkG.lka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

---IETYGDFTLTVVAERNYLN-YTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFearpSGPTIVHCSAGVGRTGTYFTIDSM
   . |.|..|..   | .  .    .||..|.  .  | ...|..  ||||  ..||.  ||  .  ...     ||| .||||||.|||||. .|.  
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievg

MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
...    .....|| |  .|  |.. ||   ||. . |.||.
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2381-2628 8.7e-50 164.2 In-house 22-265 (283) alignment
Range on Protein: 2381-2628
Range on HMM: 22-265/283.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSegqtNYVNATFLD---GFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTC
| . .   ..||..|||. . .| |..|  | .       .|.||.|.      ..   ||..| ||..|| |||.|..| .   |||| ..  .  . |
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

SQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWKERQKYPksLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRS
|||||       |.| . .  |  .   ||. .|| .    ...|. ..  | ...| | .. .      |  ...| . |..  .||| |||  |. |.
sqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..ssakstlllahyqvidWleygeqa..iinslvkfnkvislqteskkgPivvhCstgiGrt

GLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
. |.|..... ....|  .|||  || .|.    .| . .||  .|..| | 
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_PTPN6_pd Subfamily PTPN6 2339-2631 2e-48 159.9 In-house 2-299 (306) alignment
Range on Protein: 2339-2631
Range on HMM: 2-299/306.0
TSVPTKTIVQYFTRLEQTNLHTKRTFLEEHLSALDAMSiFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMtGCSEGQTNYVNATFLDG--FNRRDM
||. .|.| |  ..||... ..... .||.  .|. .    . .| . |.  ||..||||   .| |. |  |    |  ...|.|| ....   . .  
tsllakeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdks

YIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYWPAG-DEALIGPFVIDVSAEEREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWK
|||||  |..||.|||||... ||.||||. .|..|. . |..|||.  ..   |   .   .|..  | |.|....|..     ...| ..|| |  | 
yiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWP

ERqKYPKSLASLLCLLDLVEAGQRDLG---NGPITVHCMDGVTRSGLFCAI---MSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
.    ||.   .| .|. |.. |..|    .||| ||| .|. | | |  |   ...| | . . .||. ..||..|.    .|  |.|| ... ....|
dh.gvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

LAS
. .
iet

0036282 (Phosphotyrosine protein) phosphatases II 2130-2328 7.2e-48 157.9 In-house 2-164 (174) alignment
Range on Protein: 2130-2328
Range on HMM: 2-164/174.0
EDYINASFVSGYLKPKAYIATQGPLSttvfdFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEdietygdftltvvaernylnytertltirkAWDPEE
.||||||.....  .. .||.||||.     ||.|...... ..|||....|... ||  ||||                               .. .|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RRVQHFHYTSWPDMGLPLSATpLLEFITKVKEFEAR-PSGPTIVHCSAGVGRTGTYFTIDSMMDMSArEQQINVLDFVYRMRTKRVKMVQTPEQYVFIYE
| . ...|. |||.| | ... ||||.  |.|. .. |.||..||||||||||||   .. |. .   |  ...||.|...|..| .|||||.|| |.|.
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy





subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2390-2630 1.5e-46 153.7 In-house 26-269 (274) alignment
Range on Protein: 2390-2630
Range on HMM: 26-269/274.0
SENHHKNRYPDNIPLDKYRPYLMTGCSEGQ-TNYVNATFLDGFNRR-DMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN-RNDQTCSQYWPAGDEA
. ...|||| . .| .. |  | .  || . ..|.|| .. |....  .|.||| ||..||.|||||||  ...||||| ... .| | |..|.|   ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----LIGPFVIDVSAEEREGDVIIRTFLLSNTNTvaT-EssrvIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQR--DLGNGPITVHCMDGVTRSGLF
      | . | |.   .. |  .|...|....   . .    .  | .  | . .| |..  .|| |.. ||  ..  .   .|. |||  |. | | |
eiserygdveikvekiverndysvrklvlkyler..ers....vkhywytdWPd.hksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 ||  .. .|. |. .||.. | .||   | || ..||| .|| .. .|| 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0049772 (Phosphotyrosine protein) phosphatases II 2093-2335 3.5e-46 153.7 In-house 37-281 (314) alignment
Range on Protein: 2093-2335
Range on HMM: 37-281/314.0
TWEVATRQENVSKNRYINIIPYDhSRVILdTDPDAPHEDYINASFVSGYlkpKAYIATQGPLSTTVFDF----------WRMV--WQERVPVIVM-----
|. ||   .| .||||..|.|.| .||||    .    ||||||.|.|.   ...|||||||. ||.||          ||||  .. .| .|||     
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTKLVENKkrkcDPYWPEDIETYGdftlTVVAERNYLnytertltirkawdpeERRVQHFHYTSWPDMGLPlSATPLLEFITKV
                |..| .|     . ....|.|..     ... .....                ||.. ..... .|| . | .   ..||.  .
ladelsrLdaAlgKtpllildgng....neptaadlellk....eelydpelf................erlgikylripvpDgsap.lledfdeflefi

KEFeaRPSGPTIVHCSAGVGRTGTYFTIDSMMDMSareqQINVLDFVYRMRTKRV-----KMVQTPEQYVFIYEALLECLL
.|.  .. ||..|||.||.|||||. ... .|       .... . . ..| ||       .....|||.||.||||| | 
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

0043147 (Phosphotyrosine protein) phosphatases II 2128-2328 5.7e-46 151.7 In-house 3-155 (172) alignment
Range on Protein: 2128-2328
Range on HMM: 3-155/172.0
PHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLvenkkrkcdpywpedietygdftltvvaernylnytertltiRKAWDP
...||||||....| .|. .|||||||. |. |||||.... . .||.||.|                                           . ...
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

EERRVQHFHYTSWPDMGLPlSATPLLEFITKVKE-FEARPSGPTIVHCSAGVGRTGTYFTIDSMMdmsareQQINVLDFVYRMRTKRVKMVQTPEQYVFI
.|| . ...|..|||.| | ..  ||||.  ..| .  .|.||..||||||||||||   .. |.      ....... |  .|.|| ..||.|.|| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

YE
|.
yy

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2381-2630 1.8e-45 150.3 In-house 30-277 (281) alignment
Range on Protein: 2381-2630
Range on HMM: 30-277/281.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQY
| . .| |. || .|||| . .  |. |  .    .. .|.|.|| |..|..    ||||| |. .....||.|..... ..|||. .||. .   | .|
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

WPAGD-EALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGL
|| .. |  .| ...   |||..   | |.| |....      .| ..|  .. | .    |.. . ||   . |.  ..   . |. .||  || |.| 
WPddnselkygdvtvkstaeeekatyierkfkleres....getreveqlaytaWPdh.GvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

FCAIMSTIGKLKSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
. |.   . ....|  ..||   |..|||    || .  || ... .| ..| 
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2380-2637 4.3e-45 148.7 In-house 28-301 (301) alignment
Range on Protein: 2380-2637
Range on HMM: 28-301/301.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTG--CSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTC
.| |.. | |.||.. ||. .. ..|. |  | .    .  |..|.||...||....  .||.| |...|. ||||.|...    |||. . . .  . |
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

SQYWPAG--DEALIGPFVIDVSAEEREGDVIIRTFLL-----SN-------TNTVATESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEAgQRDLGN
 |||| .  ..   ||| . .. |    | .|| . .     ||        .. .. ||. . |.  . | .    .     |  . | . . |.  | 
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihr.qqkigg

GPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYEN
||. ||| |.| ||| .|..  ..   |.|| .|||  .| .|.    .|   |||  |.||. .||.  ..| |
gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_PTPN9_pd Subfamily PTPN9 2385-2629 1.6e-44 147.1 In-house 35-290 (297) alignment
Range on Protein: 2385-2629
Range on HMM: 35-290/297.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPAG
.| |.  | .|||| | . .|. |  | .   . ...|.|| |.||..... .|||| ||..||.|||||... .  ||||   . .|    |.|||| .
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DEALI--GPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQR------------DLGNGPITVHC
.|. .  | . . .   | | |  .|.. ..|..   || || .  . |..| .    |.| |||| .|. |   |             .. . || |||
eessaefgdlsvsnveveeeedykvrvleiknvk...teesrkvthfqflsWPdy.GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

MDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
  |. |.| |...  .. .|...|..||...||.||.    ..  .||| . .  | || 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2100-2332 2.1e-44 146.6 In-house 31-257 (267) alignment
Range on Protein: 2100-2332
Range on HMM: 31-257/267.0
QENVSKNRYINIIPYDHSRVILDTDpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYG
..|  .||. . .|||..|||| |      |.|||||.| || . .|.|.||.||. |. ||. .. ...|||||.|||  ... |.  |    . . | 
eknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyq

DFTLTVVAERNYLNYTERTLTIRKAwDPEERRVQHFHYTSWPDMG-LPLSATPLLEFITKVKeFEaRPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQ
|.|.    |..  .|   || ..   .   . |  ..|  |           ||.  ..| . .|   . | .|.||.||||.||...|||...   .|.
dltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgilaknq.le.ngnrPlvvacsdGvGrsGtflvidsqlerakteg

QINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
  .. ||. ..| .|. .|.| |.|..|.| | |
vsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2097-2338 4.8e-44 145.6 In-house 36-281 (307) alignment
Range on Protein: 2097-2338
Range on HMM: 36-281/307.0
ATRQENVSKNRYINIIPYDHSRVILDTDPDAphEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED--
 . . |  |||| ..   |..|... .|  |   ||| | ..   .||| .|..|||| .|...|| |. ||.|  ..|| |..|  | ||. ||| .  
eafsantdknryqdvkcqdkgrivvkfdgla..sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

-IETYGDFTLTVVAE---RNYLNYTERTL---TIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEfearPSGPTIVHCSAGVGRTGTYFTI
   ..|. . |.  .    . |   |  .   |..  |  . | .||. .. ||| | |      ....  |.        | .|||||||||.||  .|
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivai

DSMMD-MSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
  ..| | | .   .. ..|  .|..|   .||  ||....  ||| .|  |
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely

0049260 (Phosphotyrosine protein) phosphatases II 2137-2328 4.4e-43 141.9 In-house 1-144 (152) alignment
Range on Protein: 2137-2328
Range on HMM: 1-144/152.0
FVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWpedietygdftltvvaernylnytertltirkawdpeerrvqHFH
|..|| .|...||||||.. |. |||||...  . .|||||.|.|..| ||. |.                                          ...
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

YTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMdmsareQQINVLDFVYRMRTKRVKMVQTPEQYVFIYE
.. |||.| | ..  ||...  ....  ...||..||||||||||||.  .. |.      ........| ..|.|| ..|..|.|. |.||
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2093-2334 6.4e-43 141.7 In-house 24-295 (297) alignment
Range on Protein: 2093-2334
Range on HMM: 24-295/297.0
TWEVATRQENVSKNRYINIIPYDHSRVILDTDPdaPHEDYINASFVSGY--LKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
.. .| |.  . |||| .|. .| .|| |   .  . .||||| .|      ..  || .|||||.|| |||..|... | ||||..|| |. . || ||
sfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WPEDI---ETYGDFTLTVVAER----NYLNYTERTLTIRkawdPEERRVQHFHYTSWPDMGLPLS----------------ATP-LLEFIT--------K
||.      . ||. .  ...     . .  || .|  |     |.| |.|  . |||| |.|                  | | .|  .         .
wpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflq

VKEFEARP--SGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECL
.. ..|    . ...|||||||||.|     | ....  ...  .|  ..  .| .| ..||| ||. ..|.| |. |
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_PTPN3_pd Subfamily PTPN3 2380-2625 1.6e-42 140.3 In-house 29-271 (280) alignment
Range on Protein: 2380-2625
Range on HMM: 29-271/280.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFL----DGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQ
 .....| . .|| .|||| | .| |. |  |     |..|.|.|| ..    .. .    ||||| ||..|..|||.|... .|..|||| . ..|  .
pglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

TCSQYWPAG-DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAgQRDLGNGPITVHCMDGV
 | ||||   ||   | | . .. |...  ...| ..|....|   . .| | |  .. | .  . |.. |..| ... |.. .|   . |. |||  |.
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdket...keerkilqlqylaWpdh.gvPddsadflefvervrk.lrsgkeePvvvhCsaGi

TRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 |.|.. ..  .. .. .. .. . . |...|   . .|....|| .. . .
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

0046846 (Phosphotyrosine protein) phosphatases II 2126-2332 6e-42 138.7 In-house 8-171 (176) alignment
Range on Protein: 2126-2332
Range on HMM: 8-171/176.0
DAPHEDYINASFVSGYLkpkaYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGdftltvvaernylnytertltirkaw
. .. |||||... |..    .|||||||  |. ||..|...... ..|.||..|| .. ||. ||||  .                             
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

dpeerrvqHFHYTSWPDMGLPLSaTPLLEFITKVKEFEARPsGPTIVHCSAGVGRTGTYFTIDsmmdMSAREQQINVLDFVYRMRTKRV-KMVQTPEQYV
        ..... |||.| | . . |||..  ..|.  .  ||..||||||.|||||.  ..    .  .|....|.. ....| .|  ..||||||| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIYEALLE
|.||..|.
flyefell

subfamily_ptpA1_pd Subfamily ptpA1 2099-2292 6e-41 135.5 In-house 44-254 (418) alignment
Range on Protein: 2099-2292
Range on HMM: 44-254/418.0
RQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYlKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE--
.. | ||||| ||.| .|.|| |    |    ||||| .. |   || .|.|||||  |. |||||||..|. .||||..  || . ||| ||||.|   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

---TYGD----FTLTVVAERNYLNYTER---TLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEF--EARPS----GPTIVHCSAGVGR
    ||.    |    |   . ..  ||   |  || ... | | . ...|  |||  .|  . |. ...  . .   .  ||     | ||||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYFTIDSMMD
|||. |   || 
tgtfctavimmk

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2101-2332 3.3e-40 132.7 In-house 47-285 (305) alignment
Range on Protein: 2101-2332
Range on HMM: 47-285/305.0
ENVSKNRYINIIPYDHSRVILdtDPDAPHeDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGD
..  |||| ..   |. || |  ..  || .|| | .||   .|| .| || ||  |  ||| | .|..|  | || .|.|   .||  |.. . .   .
qeagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

F-----TLTVVAERN---------YLNYTERTLTIRKAwDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKvkefeARP-SGPTIVHCSAGVGRTGTYF
|      ..|  |             . ||  |.|  .   . |.|.|.|.  ||| |.| . . .||...|     |||  ||..||||||.||||.  
feekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellek.....arpskgpivvhcsagigrtgsvv

TIDSMMDMSAREQQINVLD-FVYRMRTKRVKMVQTPEQYVFIYEALLE
 .. ..|     |.|.  |  . ..| .| . .|| .||.|... .|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2096-2332 6.7e-40 131.5 In-house 31-267 (281) alignment
Range on Protein: 2096-2332
Range on HMM: 31-267/281.0
VATRQENVSKNRYINIIPYDHSRVILDT-DPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPED
|  .  |  ||||.||   | ||| |    |.    ||| | ..   .  . || ||||   |  |||||.|||    |||| ...| .. ||  |.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

IETYGDFT-LTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKefeARpSGPTIVHCSAGVGRTGTYFTIDSMMD-
     .|  |.|  |   .| .  |  .  ... | | . |. .  |||  .| |.  .|. . |..   || | | ..||||||||.|| ....  .. 
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir...ar.stppvihcsagvgrsgtlmaveialqs

MSAREQQINVLDFVYRMR-TKRVKMVQTPEQYVFIYEALLE
. ..    .. . | ..| | |   ||| .||..|.. ||.
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2383-2635 8e-40 131.4 In-house 29-284 (287) alignment
Range on Protein: 2383-2635
Range on HMM: 29-284/287.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGqTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYWP
 ..| .   . .|||| | .|.|. |  | .    | ..|.|| .. .... . .||.| |.  || ||||.... .| .....  |..   . | .|||
tfkaaeelaavkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

AGDEA-LIGPF-VIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERQKYPKSLASLLCLLDL---VEAGQRDLGNGPITVHCMDGVTRS
  .   ..| . |. .. . .| .  .|.. | . .   |. .||..|. .. | ..   | ... .   ||    .|. .   . ||. ||.  |. ||
erevPmrvGGysvvlldydikePeygvralrlidle...trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR-EYLASCEIY
|.. |..  . .|.. |..||  .| .||.    .| .  |. .. . .   | .  ..|
GillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqly

subfamily_PTPRN_pd Subfamily PTPRN 2375-2627 3.4e-39 129.3 In-house 38-290 (297) alignment
Range on Protein: 2375-2627
Range on HMM: 38-290/297.0
MSIFYSDV-SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFL-DGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN
.  . ..  . ...|. .| .|||. . .| |. |  | .  |. ...|.||... |   |. .||||| || .|| |||.|...  . |||.| ... .
lcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleee

D-QTCSQYWPAGDEALIGPFVIDVSAEE-REGDVIIRTFLLSNTNTvatESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDlGNGPITVHCM
. . |..|||   ... . . ... .|     | ..|.| | | .|   . .| . |. |. |.|.   | |  ||| .   |.   |     || |||.
gvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt...setrtvtqfhflswpee.gvPasaksllefrrkvnksyrG.rscpivvhcs

DGVTRSGLFCAIMSTIGKL-KSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
||. |.| ...|   . .| |   .||.  ....||     .| ...|. ..  .| |
dGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2376-2628 3.8e-39 129.3 In-house 19-258 (267) alignment
Range on Protein: 2376-2628
Range on HMM: 19-258/267.0
SIFYSDVSMQAgkSSENHHKNRYPDNIPLDKYRPYLMTGCSEgqtnYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDqt
|   | .|     ...|. .||. ||.| |. |  | |   |    |.||....|.... ..|.|| ||. |. ||. .| |..  |||.|  .  ..  
sdtsstisqsi..aeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..

CSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRVIRQYSFVGWKERQKYPKSLASLlclLDLVEAGQRDLGNGPITVHCMDGV
  ..||   |.      .... | |. | |  | |. |   |    ||.. .  | .  |.   .    |  |   . ..   | . || |. |.| |||
irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn....esahnvtlyyykkwnintnnkpylkpl...fgilaknqlengnrPlvvacsdGv

TRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
 ||| |  | | . ..| ||  |.|. ..|.|.    .| . |.|.|||... ||
GrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0041856 (Phosphotyrosine protein) phosphatases II 2392-2629 2.9e-38 126.7 In-house 1-171 (182) alignment
Range on Protein: 2392-2629
Range on HMM: 1-171/182.0
NHHKNRYPDNIPLDKYRpylmtgcsegQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNeinrndqtCSQYWPagdealigpf
|..||||.| .| |  |            .|.|| ...|  . . .|||| ||..||.||.||..... ..||.|.        . .|||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

vidvsaeeregdviirtfllsntntvaTESSRVIRQYSFVGWKERQKYPksLASLLCLLDLVEAgqrdlGNGPITVHCMDGVTRSGLFCAIMstigkL--
                           ..  | . || ...|      .  | .|| ... |..      .||. |||. || |.| ..|.      |  
...........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaay.....lmk

-KsegNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 .   ......||| .|..   || ...|| .......|.|
kl...gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2360-2629 3.2e-38 126.3 In-house 17-279 (439) alignment
Range on Protein: 2360-2629
Range on HMM: 17-279/439.0
TKRTFLEEHLSALDAMSIFYSDVSMQAGKsSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYN
 |. ...| .  ....|  |. ..  | . . .. |||| |  ..|  |  |       .. |.|| ...|.   ..|||||.| ..|..||||.... .
nkqeifkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

SNVIVMLNEINRNDQtcsqYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTvATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRD
.  |||| ..    .    |||. .|.  |  .. |  .    . .|| | . |     ||  | . |. .. | ...  |   . .| .|  ... . .
tvtivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerd.ttekertvlqfhyiawpdkn.vpaqashvldflrainsandk

LGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
   ||. |||  || |.|   |.  .. .||.| ..|.   || |||   .|| .  ||..|.. | | .
eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2100-2338 1.5e-37 123.9 In-house 53-293 (305) alignment
Range on Protein: 2100-2338
Range on HMM: 53-293/305.0
QENVSKNRYINIIPYDHSRVILDTDPdapHEDYINASFVSGYLKP-KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETY
. ...|||| ..   |.| | ||  .     ||| | .|   . | | .|..||||  |. .|| || |..|  |||| | ||  | ||  |||      
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

GDFTLTVVAE----RNYLN-YTERTLTI-RKAW-DPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMM
 ..   .| |     . ..  .|  .|. . ..   ..  |.|...| ||| |.|      ||... ..  .     | .||||||.|||||  .|. ..
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhcsagigrtgtivaieyil

DMSAREQQIN-VLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCGY
.  | ...   . ..|  .| .|   .|.  ||.||.  .|. .|  |
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2390-2626 1.7e-37 123.9 In-house 1-236 (237) alignment
Range on Protein: 2390-2626
Range on HMM: 1-236/237.0
SENHHKNRYPDNIPLDKYRPYLMTGCSEgqTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAGDE-A
|||. |||| . .  |. |  |    |.  ..|.|||.|.||.     |||.| ||. . .|||.|... .  |||||   |..|.. | .|||  |. |
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

LIGPFVIDVSAEEREGDVIIRTFLLSNTNTVAteSSRVIRQYSFVGWKERQkYPKSLASLLCLL-DLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMST
  | . . .  .|   |  .|..|||.  |.     |.| || |  | .|   |.  |.|| .  ....  .     ||  .||  || |.|.|  | . 
aygvltvslkkkeefsdytvrslllskrltlk..evrlihqyqftswpdrg.vpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

IGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
. . | .  .|..  |. . .    .. ...||..||... 
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_PTPN13_pd Subfamily PTPN13 2383-2630 2.7e-37 123.5 In-house 28-270 (273) alignment
Range on Protein: 2383-2630
Range on HMM: 28-270/273.0
SMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSegqtnYVNATFLDGFN--RRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EINRNDQTCSQY
. . ||. ||..|||| . .| |. |  |    .     |.||...       .  |||.| || .||.|||.|... ...||.|.  | ...   | .|
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPAGDEA--L-IGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRdlGNGPITVHCMDGVTRS
||   .      . . ...   ..  .  .|.. .....   .. || . .  || | .  . |.| |.|| ..  |   |.   .||| |||  |. ||
wPesknkklkvsnrlevellkvqkldgfvvralavkdse...sgesrevahlnfvkwPdh.gvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
| . .|   .| .. . ..|| . |.|||.    .| ...||.... .. | | 
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2389-2630 3.6e-37 122.8 In-house 17-265 (270) alignment
Range on Protein: 2389-2630
Range on HMM: 17-265/270.0
SSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWPAGDEA
   ... ||| | .|  . |  | .  .. .|.|.|| .. ||.  .  |||.. ||. |...|||||.. ... |||. ...  . . |..||||  . 
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

LI--GPFVIDVSAEE-REGDVIIRTFLLSNtntVATESSRVIrQYSFVGWKERQKYPK-----SLASLLCLLDLVEAGQRDLGNG-PITVHCMDGVTRSG
 .      | | |.. .  .  |.| |  .      |. |..  . .. | ..   ..     |  .|| .|  | . ...| .. |. ||| .|| |.|
kvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

LFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
.. |.  ..  |......|| . ...|||    .|   ||| ... .|.||  
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPN1_pd Subfamily PTPN1 2380-2608 6.2e-37 121.9 In-house 20-250 (290) alignment
Range on Protein: 2380-2608
Range on HMM: 20-250/290.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLmtgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQ
||..... |  ||. .||| |  | |. |  |     .....|.||....  . .  || || || .||. ||.|... .|  .||||.. ... . | |
sdfptreaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPAGDE--ALIGP---FVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKERqKYPKSLASLLCLLD-LVEAGQRDLGNGPITVHCMDG
||| |.|  .|.     . ... .|||.   ..|.. | |   . |. .|.| .. .. | .    |.| |..| .|  . |.|      ||  .||  |
ywPqgeeekellledtklkvkliseerksyytvrllelen...lktqetreilhfhyttwpdf.gvpespaaflkflfkvresGslssdvGpavihcsaG

VTRSGLFCAIMSTIGKLKSEGN---IDVFHAVKKLRKCS
. ||| || . . . ... ...   .|. . . .|||  
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyr

0044763 (Phosphotyrosine protein) phosphatases II 2113-2332 1.1e-36 121.5 In-house 1-169 (178) alignment
Range on Protein: 2113-2332
Range on HMM: 1-169/178.0
PYDHSRVILDTDPDAPHEDYINASFVSGYlkpkAYIATQGPlsttvFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIEtygdftltvvaernyl
|.|..||.|.. .. .  ||||||.. ..     |.....|      |........ . .||.||. .|. . ||||||||. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

nytertltirkawdpeerrvQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMDMsareqQINVLDFVYRMRTK
                     ..... .||.| | .   .|||.  ..|. ... ||..|||||||||.||   .. |. .     .... . . ..| .
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RVkMVQTPEQYVFIYEALLE
|  .|..|.|. ..||  |.
Rp.ivpnpgqlrqLyefelr

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2099-2335 2.3e-36 120.2 In-house 32-271 (285) alignment
Range on Protein: 2099-2335
Range on HMM: 32-271/285.0
RQENVSKNRYINIIPYDHSRVILDTDpdapHEDYINASFVSGYLKP-KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE-
 . |   ||| ..   . .||.|         ||| ||..    |   .||.|||||  |. |||.|..||..  ..||  |.|    ||  |.|| .  
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

--TYGDF--TLTVVAERNYLNYTERTLTIRKAWDP--EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARpSGPTIVHCSAGVGRTGTYFTIDSM
   .| .  ||| . |         .||. .. |   |   ..| .   |||   |  | |..|.   ||. . .   |  |||||||||| |.  ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidya

MDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
      . .|..|| |  ||. |.. ||.  |..|.|  |.| ..
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfi

subfamily_PTPN23_pd Subfamily PTPN23 2390-2626 4.7e-36 119.1 In-house 41-277 (288) alignment
Range on Protein: 2390-2626
Range on HMM: 41-277/288.0
SENHHKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAGD--E
  . .|||. | .| |. |  |     ... .|.||.|. .       .|||| ||| |. |||.|.|.  |.||||| .  ..... ...|||.     
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvaTESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEA---GQRDLGNGPITVHCMDGVTRSGLFCAI
   |.. . .. ... . .. |.. |.  .   ..  . ..   .  | |    |.|  .|| .|| ||.    ..   . |. |||  || |.|.|. .
vkfgdlsvtlksvretethvervlkletld...adavksvshlqltsWpel.GvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

MSTIGKLKS-EGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
.. . .|.  .| .|. . |..||.    ||  .||.    ..| 
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2098-2329 1.1e-35 117.7 In-house 48-285 (310) alignment
Range on Protein: 2098-2329
Range on HMM: 48-285/310.0
TRQENVSKNRYINIIPYDHSRVILDTDpDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE--DI
. .... |||| ...  | ||| |  |  . .|||| | .|      ...| .||||  |. |||||..|||   |..| | .|. . ||  |||     
aykkymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

ETYGDFTLTVVAERN-YLNYTERTLTIR--------KAWDPEERRVQHFHYTSWPDMGLPLSATPLL--EFITKVKefearpSGPTIVHCSAGVGRTGTY
||||   .| ..|    ..  . ..|.         .  . .| ||.  ..  |||.|.|      .   ....|.       || .||||||..|... 
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr......hgpcvvhcsagkdrlyvv

FTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEA
 ...  .| . | ..... . .  .. .|.. .||. ||..|   
valklkidkldrglkvdaeevktellksraiciqtelqyliidrv

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2100-2336 1.4e-35 117.7 In-house 41-273 (288) alignment
Range on Protein: 2100-2336
Range on HMM: 41-273/288.0
QENVSKNRYINIIPYDHSRVILDTDPDAphedYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYG
 .| ...|| |.   | .|| |. |||     ||.|  ||    ..  | .| || .|.  .|.|. .. |  ||||..|.|  |.| . |.|  .    
ianptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

DFT---LTVVAERNYLNYTERTLTIRKAWDPEERR-VQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMMDMSA
 .      |  .|. .. . .  ..|     ||.  |.. |.  |.| |.| .  . | ... .|...     | .||.|||||||||   |  ....  
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlililialeslr

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
 . .. .  .. ..| .| | .||  ||....  .|| || 
lddflgirsllaklreerfkaiqtemqylyvhrcvleelll

0051429 (Phosphotyrosine protein) phosphatases II 2420-2630 2.4e-35 117.9 In-house 4-226 (272) alignment
Range on Protein: 2420-2630
Range on HMM: 4-226/272.0
TNYVNATFLDGFNR---RDMYIATQMPLQHTVEDFWRMiYDYNSNVIVMLNEINRND-QTCSQYWP------------AGDEALIGPFVIDVSAEEREGD
..|.|| ...|..|   .........||..|..||||. .... ..||.| . .  . . |..|||            .  . |.| ... .  ||   |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VIIRTFLLSNTNTVATEssRVIRQYSFVGWKERQKYPKSlasLLCLLDLVEAgqrdlgNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNID-------
.|.|..||... .  .   | .... . .|  .   ...   || ||.|. .      .||. |||. |. |.|...|.   .  .  |  .|       
yilrellltlllsagea..revmhlhytdwpdhgvpqea...llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 ...||..||..   .|..|||||.......|.| 
yleeaveelraqrpgavqteeqylflyeallellr

0051082 (Phosphotyrosine protein) phosphatases II 2128-2331 8.5e-35 114.9 In-house 1-150 (151) alignment
Range on Protein: 2128-2331
Range on HMM: 1-150/151.0
PHEDYINASFVSGYlkpkaYIATQGPLSttvfDFWRMVWQERVPVIVMLTKLVENKkrKCDPYWPE-Dietygdftltvvaernylnytertltirkawd
|..||||.|.| |.     .....|||.    ||....... . .||.|....|..  .|  |.|| .                                
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

peeRRVQHFHYTSWPDMGLPLSATPLLEFITKVKEfeaRPSGPTIVHCSAGVGRTGTYFTIDSMMDMsareqqINVLDFVYRMRTKRVKMVQTPEQYVFI
   ..| |.....||| |||||   .|||. .. .    ..||..||||||.|||||   .. |. .      ... . .  .| ||  .||...|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YEALL
. |||
lfall

PTPc_DSPc_SM00012 2232-2332 2.9e-34 112.8 In-house 2-105 (105) alignment
Range on Protein: 2232-2332
Range on HMM: 2-105/105.0
VQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARP--SGPTIVHCSAGVGRTGTYFTIDSMMDMSARE-QQINVLDFVYRMRTKRVKMVQTPEQYVFIYE
|.|.|||.|||.|.| .....||.. .||...     |.|..||||||||||||. ..| ....  .| ........| ..|..| .|||| |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_PTPN14_pd Subfamily PTPN14 2381-2631 5.5e-33 109.2 In-house 38-298 (300) alignment
Range on Protein: 2381-2631
Range on HMM: 38-298/300.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMtGCSEGQTNYVNATFLDGF--NRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCS
|  ....|  || .|||..| .| .. |  |.  . | .|.|.||. .      ..  ||..| ||..||.|||.|... . ..|||| |.. .  . . 
dallstaklpenaeknrfkdvlPyednrvels.ptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPAG----DEALIGPFVIDVSAEEREGDVIIRTFLLsntNTVATESSRVIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQRDL--------GNGPI
.|.|      ...  | | .     |  . || ... |   . . ..  | .    .. | . .. |. . . |  |. |.. .|           . |.
kyfPkleskkktvefgkfkvttkfsedsdsvittglkl...khlpskeertvwhlqytDWpd.hgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

TVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLAS
 ||| .|| |.|        |  |. . .||. .....||.    .|..  || ....|. .|| .
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

0049772 (Phosphotyrosine protein) phosphatases II 2381-2629 6.6e-33 110.2 In-house 35-280 (314) alignment
Range on Protein: 2381-2629
Range on HMM: 35-280/314.0
DVSMQAGKSSENHHKNRYPDNIPLDkYRPYLmTGCSEGQTNYVNATFLDGFnrRDmYIATQMPLQHTVEDF----------WRMI--YDYNSNVIVM---
. .. ...  .|..||||.| .| |  |  |  | .   ..| || ..|||  .. .|||| ||..||.||          |||.  .|.|. .|||   
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lk.fIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LNEINRNDqtcsQYWPAGDEALIGpfvidvsaeeregdviirtfllsntnTVATES---SRVIRQYSFVGWKErQKYPkSLA
                  |...  |      ...| | .|.                           .. ..    .| . .|  . .      | .|.
evladelsrLdaAlgKtpllildgng....neptaadlellk..........................eelydpelferlgikylripvpD.gsap.lle

SLLCLLDLVEAGqrdLGNGPITVHCMDGVTRSG--LFCAIMSTIGklksegNIDVFHAVKKLRKCSG-----RMVPSEEQYLYIHDVVREYL
 .. .|...|.      .||. |||..|. |.|  ...|..          ....  |.. .|..       ..... |||..|.....|||
dfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

0036282 (Phosphotyrosine protein) phosphatases II 2420-2623 1.9e-32 107.7 In-house 2-164 (174) alignment
Range on Protein: 2420-2623
Range on HMM: 2-164/174.0
TNYVNATFLDGFNRRDMYIATQMPLQhtvedFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAgdealigpfvidvsaeeregdviirtfllsntntVA
..| ||..||.. . . .||.| ||.     ||.|.........|||.| . ..   | .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

TESSRVIRQYSFVGWKERQKYPKSLasLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKsEGNIDVFHAVKKLRKCSGRMVPSEEQY
.  .| . || ...|  ..  . |   || ....||  . . ..||. |||. || |.|...|..  .  |. |. .|... |..||.. ..||....||
edlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

LYIHD
 ....
rflyy

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2386-2626 2.3e-32 107.1 In-house 2-238 (239) alignment
Range on Protein: 2386-2626
Range on HMM: 2-238/239.0
AGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAG
| |   |. |||| . .  |. |  |     . ...|.||..|  ..     |||||  .. .  |||||...    |||||   |.   . | ||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

DEALIgPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAgQRDLGNGPITVHCMDGVTRSGLFCAIM
       . . .   |   | |||||..|.   |     | . || |  | ..   |.  ...| |   .   .   |  |  .||  || |.| |  | 
tskyc.nlrvtlrktevfadyiirtfvmsq...vgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvid

STIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVR
. . . | .  .|.|  || .|.   .|| . |||..||  | 
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2388-2627 2.8e-32 106.8 In-house 3-238 (239) alignment
Range on Protein: 2388-2627
Range on HMM: 3-238/239.0
KSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQTCSQYWPAGDE
|   |. |||| . .  |. |  |     . ...|.||..|  ..     |||||  .. .  |||||...    |||||   |.   . | ||||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

ALIgPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAgQRDLGNGPITVHCMDGVTRSGLFCAIMST
     . . .   |   | |||||..|.   |     | . || |  | ..   |.  ...| |   .   .   |  |  .||  || |.| |  | . 
kyc.nlrvtlrktevfadyiirtfvmsq...vgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidam

IGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
. . | .  .|.|  || .|.   .|| . |||..||  | |
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2105-2357 3.1e-32 106.5 In-house 46-296 (312) alignment
Range on Protein: 2105-2357
Range on HMM: 46-296/312.0
KNRYINIIPYDHSRVILDTDpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWP--------EDIE
 ||| ||  .|  |  |  |     . || | ||    ||. ...|||||  |.  ||...       |..|. .||.   ||  |          ||  
lnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

TYGDFTLT-VVAERNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEfearPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA
 | ..     .  .   . | | | .      .| ...|. ..|||| |.| |    | ... ||        | | |||||||||||   |.||.    
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaalr

REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLlcgYTSVPTKTIVQYFTRLEQTN
  .. || |    .|  | . |..  |||.   ..|| |   |.    |   | .|....| 
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl...yskglykrneqewtkfkety

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2228-2369 8.3e-32 105.1 In-house 87-229 (440) alignment
Range on Protein: 2228-2369
Range on HMM: 87-229/440.0
EERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFE-ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFI
| | ....|| .||| |.|  | |.|..|  |.| .    .|| .||||||.||||   ..||..  . | .||... |.  || .| .||||||||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YEALLECLLCGYTSVPTKTIVQYFTRLEQTNLHTKRTFLEEHL
.||.|| |||| | .    |..   ...  | || .. |....
heavlegllcgdtliledditerveqiqwpnphtdksplqqef

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2133-2325 2e-31 103.8 In-house 78-272 (301) alignment
Range on Protein: 2133-2325
Range on HMM: 78-272/301.0
INASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIET---YGDFTLTVVAERNYLN--YTERTLTIRKAW-D
| | ...   .|. .|||||||. |  ||| |. |  |  ||||.. ||....||. | | .|.     | |..... .   ||   ..||| .. .  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

PEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVF
 . | | |. |..|.| |.| | . | ...  ||. |     | .||||||.||. .. . . .      ...|.. . . ..| .| . ||| .|  .
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

subfamily_CG42327_pd Subfamily CG42327 2103-2260 6.5e-31 102.2 In-house 29-191 (319) alignment
Range on Protein: 2103-2260
Range on HMM: 29-191/319.0
VSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLK-PKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE-----DIE
  |.|.||..|  ..||.|.  .| ... |..||.| || . |  |||.| .|  .  ||||.||. .  ||| ||.| |.  ..|  |.|      . .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TYGDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQHFHYtSWPDMGLPLSATPLLEFITKVK
.|||. .|.       .|   || ...  . | | . |. |  |.. ..| . ..|.  . .|.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

0043147 (Phosphotyrosine protein) phosphatases II 2418-2623 6.6e-31 102.7 In-house 3-155 (172) alignment
Range on Protein: 2418-2623
Range on HMM: 3-155/172.0
GQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEInrndqtcsqywpagdealigpfvidvsaeeregdviirtfllsntNTV
. ..|.|| .||.    | .|||| ||..|..|||||..... ..||.|.|                                               . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

ATESSRVIRQYSFVGWKERQKYpkSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIgklkseGNIDVFHAVKKLRKCSGRMVPSEEQ
..  .| . || ...|        .|. || .|....  .    .||. |||. || |.|...|.   .       ......||. .|.. . .|....|
pellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YLYIHD
| ....
yrflyy

0046846 (Phosphotyrosine protein) phosphatases II 2418-2630 8.1e-30 99.3 In-house 10-174 (176) alignment
Range on Protein: 2418-2630
Range on HMM: 10-174/176.0
GQTNYVNATFLDGFnrrdMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPAGDEALIgpfvidvsaeeregdviirtfllsntnt
.  .|.|| ...|     ..|||| || .|..||..|..... ...|.|.|    .   | .|||   .. |                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

vatessrvirQYSFVGWKERQKYPKslASLLCLLDLVEAGQRDlgNGPITVHCMDGVTRSGLFCAIMstigKLKSEGNIDVFHAVKKLRKCSG-RMVPSE
          || ...| . .  .   . || ||....  ...  .||. |||. |. |.|...|.      |..| ...|..|....|..   ..|...
..........qylhlpwpDhgvpdl..elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYLYIHDVVREYLA
||| .........| 
eQyrflyefellllk

0049260 (Phosphotyrosine protein) phosphatases II 2427-2623 8e-29 95.7 In-house 1-144 (152) alignment
Range on Protein: 2427-2623
Range on HMM: 1-144/152.0
FLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWpagdealigpfvidvsaeeregdviirtfllsntntvatessrvi
|.||...  ..|||| |. .|..|||||..... ..||||.|   ..   | ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rQYSFVGWKERQKYPKSLASLLCLLDLVEAgqRDLGNGPITVHCMDGVTRSGLFCAIMSTIgklkseGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
 || .. |     .. |   | .|| . ..  .   .||. |||. || |.|...|.   .       ......||. .|..   .||...|. ....
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2392-2628 9.2e-29 95.0 In-house 56-282 (290) alignment
Range on Protein: 2392-2628
Range on HMM: 56-282/290.0
NHHKNRYPDNIPLDKYRPYLMTGcseGQTNYVNATFLDGFNrrDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWP--AGDEALI
. .|||| | .  || |  |  |   .. .|| | ...| .   |.| || .|. || |.|||. . .  .|||| |.  . .  |.||.|  .|.   .
efkknrykdvvcndktrvilkdG...ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GPFVIDVSAEEREGDVIIrTFLLSNTNtVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVeagqRDLgNGPITVHCMDGVTRSGLFCAIMSTIGK
| . .  | |. . . ||   .||  . . .  . ... .  . | ..   ..|  .|| .|  .    | . .||..|||  |. |.| | ||  ..  
Geitvlcseeddkdanii.kktlsvrd.kdsGkehklkhlkikswpdks.valstlallrtlril....rka.sGpvvvhcsaGiGrtGtfvaievglqi

LKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREY
|    ..|.   |. ||..    |  . ||| . ... ..
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2096-2203 4.2e-27 89.8 In-house 41-160 (350) alignment
Range on Protein: 2096-2203
Range on HMM: 41-160/350.0
VATRQENVSKNRYINIIPYDHSRVILDTDPDAP--------HEDYINASFVSGY-----LKPKA-YIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVE
..   |  .|||| ||.||.||||.|   . ..         .|||||....        .|.  |||||.||  || ||.... .  |.||..||..||
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

NKKRKCDPYWPEDieTYGDFTL
.  .||. ||.|   .| |.|.
lnlekcyrYWqeg..sydditv

subfamily_egg_pd Subfamily egg 2096-2331 6e-26 85.8 In-house 34-267 (307) alignment
Range on Protein: 2096-2331
Range on HMM: 34-267/307.0
VATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENkkRKCDPYWPED-
 |  ..|  | |   .   | ||| |.       .|.| |  |.|      .| .| ||  || ||||||.||.|. |||||  .|.   .|. |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

---IET-YGDFTLTVVAE--RNYLNYTERTLTIrKAWDPEERRVQHFHYtSWPDMGLPLSatPlLEFITKVKEFearpSGPTIVHCSAGVGRTGTYFTID
   . |  | . .. .    .    ..   | .    | ||| ..|. .  .  ..   |  | |. . |...     | |..|..  || ...|  .|.
sdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnssdvys..p.lrvlrklrnl....skpvvvqdilGvskaatlvaie

SMMDMSAR--EQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
  .    |    .  ||  |  .| .|   |... .|.|.|  .|
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2385-2630 1.1e-24 82.1 In-house 34-278 (307) alignment
Range on Protein: 2385-2630
Range on HMM: 34-278/307.0
QAGKSSENHHKNRYPDNIPLDKYRPYLMTgcSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYWPA-
..   | | .|||| |    || |  . .  .   ..|. | .|    .   .|..| ||. |. .|| |. . . . ..|| . |.     | ||||. 
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

-GDEALIGPFVIDVSAEEREGDVII--R-TFLLSNTNTVATESSRVIRQYSFVGWKERQKYPKSLASllclLDLVEAGQRDlgNGPITVHCMDGVTRSGL
 |..   |     .| ..   . .        ... . . .. || |... .  | .|   .  |..    ..|.|| . |  . |. |||  || ||| 
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlta....inlleavryd..tnpvvvhcsaGvGrsGt

FCAIMSTIGKLKSEGN-IDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
  ||     |. .  |  |. . |..||.     . .| ||||.| |. ||. 
ivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl

0048076 (Phosphotyrosine protein) phosphatases II 2219-2331 1.9e-24 81.4 In-house 34-140 (145) alignment
Range on Protein: 2219-2331
Range on HMM: 34-140/145.0
LTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPsGPTIVHCSAGVGRTGTYFTIDSMMDmsareQQINVLDFVYRMRTKRVKMVQ
|..    . .|| . ...|..|||.| | ..  ||||.  ..|. ... ||..||||||||||||.  .. |.      ..... . . ..|..| ..|.
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavp

TPEQYVFIYEALL
.|.|. |.||..|
npgqlrflyefel

0044763 (Phosphotyrosine protein) phosphatases II 2403-2628 2.5e-24 81.3 In-house 1-170 (178) alignment
Range on Protein: 2403-2628
Range on HMM: 1-170/178.0
PLDKYRPYLMTGCSEGQTNYVNATFLDGFnrrdMYIATQMPlqhtvEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGDEaligpfvidvsaeere
||| .|  |..   .  . | ||.. ...    .|.... |     .|......... ..||.|.|  ..  . | .||| . .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

gdviirtfllsntntvatessrviRQYSFVGWKERQKYPkSLASLLCLLDLVEAGQRdLGNGPITVHCMDGVTRSGLFCAIMSTIGKlksegNIDVFHAV
                         || ....      . .|. .| .....|. .    .||. |||. || |||...|.   .       ......|.
........................iqylhipipDhgvpd.llehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

KKLRKCSGrMVPSEEQYLYIHDVVREY
. .|..   .||...|. ..... ...
elvrerRp.ivpnpgqlrqLyefelrl

0048179 (Phosphotyrosine protein) phosphatases II 2219-2328 2e-23 78.1 In-house 36-139 (144) alignment
Range on Protein: 2219-2328
Range on HMM: 36-139/144.0
LTIRKAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPsGPTIVHCSAGVGRTGTYFTIDSMMdmsarEQQINVLDFVYRMRTKRVKMVQ
||    .. .|| . ......|||.| | ... ||||.  ..|. ... ||..||||||||||||. ... |.     ...... . ....|..|  .|.
lteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavp

TPEQYVFIYE
.|.|. |..|
npgqlrfLle

0051082 (Phosphotyrosine protein) phosphatases II 2420-2625 2.6e-23 77.7 In-house 3-149 (151) alignment
Range on Protein: 2420-2625
Range on HMM: 3-149/151.0
TNYVNATFLDGFnrrdmYIATQMPLQhtveDFWRMIYDYNSNVIVMLNEINRNDqTCSQYWPAGDealigpfvidvsaeeregdviirtfllsntntvat
..| |.....|.     ......||.    ||........ ..||.|..   .. .| .|.|. .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

essRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAgqrdLGNGPITVHCMDGVTRSGLFCAIMSTIgkLKsegnIDVFHAVKKLRKCSGRMVPSEEQYL
   . .... ...|..  . | |....| .|.|...     .|||. |||. |. |.|...|..  .  |.    .... |.. .|.. . .| ...|.|
...ievlhipildwpdp.glplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqfl

YIHDVV
... ..
fqlfal

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2392-2619 3.3e-23 76.9 In-house 50-271 (301) alignment
Range on Protein: 2392-2619
Range on HMM: 50-271/301.0
NHHKNRYPdNIPLDKYRpyLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EINRNDQTCSQYWPA--GDEALI
...|.||| ..| .      .   ..|.   . | ...   . . .|||| ||. | |||| |.  |. . ||||  ..... . |..| |   ...  |
pkdkhryp.tvPckPst..avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GPFVIDVSAEER--EGDVIIRTFLLSntNTVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRdlgngPITVHCMDGVTRSGLFCAIMSTI
| | | .  .|   . ... ||. .   ..    ..| .  | .. | .|.  ||| | |  |..||   ..     || ||| .|. ||  | .     
grfkikiknkelilnkkiskrtleve..dstgkfatrtvthyqysewtdrg.vPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteyla

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYL
 ..... .|.. .|.|.||.   . |  ..|  
reveadptieltealkhlrehrwngvqtnsqly

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2372-2634 4.5e-23 76.4 In-house 28-292 (305) alignment
Range on Protein: 2372-2634
Range on HMM: 28-292/305.0
LDAMSIFYSDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCsegQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EIN
. ||  |     |.| | .....|||| |   ||. |  | .       .|. | ..        .| || ||..|  ||| | .. . . | ||   ..
fvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnlle

RNDQTCSQYWPAGDEALIG----PFVIDVSAEEREGDVIIRTFLLSNTNTV-----ATESSRVIRQYSFVGWKERQKyPKSLASllcLLDLVEAGQrdLG
.  . |..|... |.  .        | |  |  .   . .      |.||     . |..| . .| .. | .|   | .  .   .|.|.|  .    
kgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv.paadla...ilellekar..ps

NGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVF-HAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEI
 |||.|||  |. |.|    .   . .| .   |.   . ..|.|.     . ...|||..|.|. .|.   ..
kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2418-2631 8.5e-23 75.8 In-house 65-273 (288) alignment
Range on Protein: 2418-2631
Range on HMM: 65-273/288.0
GQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLSNT
    |..|  .   . .   | .| ||. |.| .|.|. . . . ||||.|. ..  .   .|.|   |..| || .  .|  .  . | ...  || ..
dpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllris

NTVATESsrVIRQYSFVGWKErQKYPKSLASLLCLLDLVEAGQRdlgngPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPS
... ..   ....  .  |.. .  |..  | | ||. ... |.     || ||.  || |.| .  |.  .  |... .. . . ..|||.   . . .
kegeekv..ivkilhlleWdd.dgvPenylsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqt

EEQYLYIHDVVREYLAS
| ||||.| .| |.|. 
emqylyvhrcvleelll

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2384-2629 1.5e-22 74.6 In-house 46-289 (305) alignment
Range on Protein: 2384-2629
Range on HMM: 46-289/305.0
MQAGKSSE-NHHKNRYPDnIPLDKYRPYLMTGCSegQTNYVNATFLDGFN-RRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLN-EINRNDQTCSQYW
..| .|.. .  |||| | .| .     ..   |   ..|. | ..         .|..| ||..|...|| |. . . . ||||   ..     |.|||
fnanqsadiaitknryqd.vpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PAGD--E-ALI-GPFVIDVSAE-EREGDVIIRTFLLSNTntVATESSRVIRQYSFVGWKERQKYPKSLASLlCLLDLVEAGQrdlgnGPITVHCMDGVTR
||       |  |  | .||     | |  |.  ||  |   . . .  .|.  .  | .|   |  |.||  ||  .   .      || |||  |. |
paaqgeklelksgivvenvsgskpmerdaeiqitllnlt..ysgdqkmsvrhlqwtewpdrgvppckltsl.ellsairgsk.....vpivvhcsagigr

SGLFCAIMSTIGKLKSEGNID-VFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
.|   ||   . |.  . .   . . || ||      . .. |||.|| |. .|.
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2115-2331 1.6e-22 75.0 In-house 31-256 (290) alignment
Range on Protein: 2115-2331
Range on HMM: 31-256/290.0
DHSRVILDTDPDAPHEDYINASFVSgYLKPKAYIATQGPLST-------TVFDFWRMVWQERVPVIVMLTKLVENKKR----KCDPYWPEDIE---TYGD
 ..||.|        .||| |..|. . .  . |.|| |.         |...|| |. ||.|  .||| .  |...      |  | || ..   ....
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

FTLTVVAERNYLNYTERTLTIRkAWDPEERRVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEArpsgPTIVHCSAGVGRTGTYFTIDSMMDMSA-REQQ
.|.      .  .  .|.|...   | ||  |.|  . .| ..  . .   ||. | |||  ..    | ||||  |. |  .  .|.  . . |  ...
ltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiilgyQkiaetsgs

INVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
... | .. .| .| ......... |.  ...
vkledvlkalrkqralaitsalelafvdagiv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2153-2327 3.2e-22 73.4 In-house 99-281 (302) alignment
Range on Protein: 2153-2327
Range on HMM: 99-281/302.0
PLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE---TYGDFTLTVV-AERNYLNYTERT------L--TIRKAWDPEERRVQHFHYTSW
|   |.  .| .. | .| ..| |...||....|| .|. ....   ..| .|.. |  . .  ..|..       .  .  |  .  .. |. .....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDMGLPLSATPLLEFITKVKEFEARpsgpTIVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIY
|| | |  | . |. .   . .        .||||||||||||  .|   ... ....  ..|. |  .|. |   ||. .| ... 
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2381-2625 1e-21 71.8 In-house 41-286 (310) alignment
Range on Protein: 2381-2625
Range on HMM: 41-286/310.0
DVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEgQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQY
| |.      .. ||||| | . ||. |  |    |    .|. | ..     |. .| .| |||||. ||||||..  .. |..|  . .. .  |  |
dssltyeaykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPA-GDEALIGPF-V--IDVSAEEREGDVIIRTFLLSNTNTVATESSRVIRQYSFVGWKERQKypKSLASLLCLlDLVEAGQRDLGNGPITVHCMDGVTR
||. |     |   |  .  |.|| |   .  ||.  |       .     . |.. | .     . .    |   . .    ..  ||  |||  |. |
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd..rgvpdekch.tvpqrllaqvrhgpcvvhcsagkdr

SGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
 .. .|.  .| ||.   ..|. . . .|.|     . .| |||.|. | 
lyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2145-2328 1.2e-21 71.8 In-house 5-198 (199) alignment
Range on Protein: 2145-2328
Range on HMM: 5-198/199.0
KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE---TYGDFTLTVVAERNYLNY--TERTLTIRKAWDPEERRVQHFHYTS
. ||||| ||  |. |||.|||.     |||.     ||.     |||        || ...|. .     .|  |   ||   .  |  | . |. .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGLPLSATpLLEFITK----VKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMdMSAREQQINVLD---FVYRMRTKRVKMVQTPEQYVFIYE
| .   |  |  .. |.       | .|     | ||||| | | || . ..|  .  |  | .  |.|      |.|  |. .. . ..| |||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2145-2328 1.2e-21 71.8 In-house 4-197 (198) alignment
Range on Protein: 2145-2328
Range on HMM: 4-197/198.0
KAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIE---TYGDFTLTVVAERNYLNY--TERTLTIRKAWDPEERRVQHFHYTS
. ||||| ||  |. |||.|||.     |||.     ||.     |||        || ...|. .     .|  |   ||   .  |  | . |. .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGLPLSATpLLEFITK----VKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMdMSAREQQINVLD---FVYRMRTKRVKMVQTPEQYVFIYE
| .   |  |  .. |.       | .|     | ||||| | | || . ..|  .  |  | .  |.|      |.|  |. .. . ..| |||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

PTPc_DSPc_SM00012 2525-2626 1.8e-21 71.7 In-house 2-104 (105) alignment
Range on Protein: 2525-2626
Range on HMM: 2-104/105.0
IRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLG-NGPITVHCMDGVTRSGLFCAIMSTIGKLKSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIH
...| . ||..  . |..  |.| ||. |.  ... . ..|. ||| .|| |.| |.|.   . .|..| ...|.|  ||.|||   .|| .|||||...
vkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DVVR
... 
rall

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2435-2623 2.5e-21 70.8 In-house 5-198 (199) alignment
Range on Protein: 2435-2623
Range on HMM: 5-198/199.0
DMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEA--LIGPFVIDVSAEEREGDVIIRTFLLSNtNTVATESSRVIRQYSFV
  ||||| ||..|. |||.|...  |  |||.|. ..| .   . |||. . .    | . . . .   . |  | ...|.| || |  |.| | .| | 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.nttappstreishyqft

GWKERQKYPKSLAS-LLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKL-KSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
 |||.     .|   ..     |     .  . |. ||| ||   .|.| |.   .    .|    .|.|   |.||..   .. | ..| .|..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2436-2623 2.6e-21 70.7 In-house 5-197 (198) alignment
Range on Protein: 2436-2623
Range on HMM: 5-197/198.0
MYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDQ-TCSQYWPAGDEA--LIGPFVIDVSAEEREGDVIIRTFLLSNtNTVATESSRVIRQYSFVG
 ||||| ||..|. |||.|...  |  |||.|. ..| .   . |||. . .    | . . . .   . |  | ...|.| || |  |.| | .| |  
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.nttappstreishyqfts

WKERQKYPKSLAS-LLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKL-KSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
|||.     .|   ..     |     .  . |. ||| ||   .|.| |.   .    .|    .|.|   |.||..   .. | ..| .|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_eak_pd Subfamily eak 2091-2248 9.2e-21 68.6 In-house 41-197 (332) alignment
Range on Protein: 2091-2248
Range on HMM: 41-197/332.0
MYTWEVATRQENVSKNrYINIIPYDHSRVILdTDPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPY
. . ....| |.| .|  ..|.|||.  | | |     .. ||||| .      . || |  .  . || ||.|| ... | ||.| . ||.|  | | |
llsisetarleavnrn.vvkivpydrylvrl.tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPEDI---ETYGDFTLTVVAERNYLNYTERTLTIRKAwdPEERRVQHFHYTSWPDMGLPLS
.|..      .| . ..     .  ..  | | ..|    |  ||.|...  | .. ||  
fpdktreelkfGildverkefvkrniletrllelskG..nethrvlhykvfGwtettlpky

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2384-2484 1.5e-20 68.0 In-house 37-146 (392) alignment
Range on Protein: 2384-2484
Range on HMM: 37-146/392.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-----DQTCSQ
 ....   | .|||| ...|.|. |  |       ...|.||.....|.    |||.|.|   ...|||||... |   |.|.....       ..|..|
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaq

Y----WPAGD
.    ||  |
fhftewPdkd

subfamily_ptpA1_pd Subfamily ptpA1 2386-2589 2.4e-20 67.7 In-house 41-256 (418) alignment
Range on Protein: 2386-2589
Range on HMM: 41-256/418.0
AGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRdMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPA--
 |    |  |||| . .|... |  |     .  ..|.|| ..||   .  .|.|| ||  |. |||||...    .||||.  . |    | .|||   
egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

GDEA-LI---GPFVIDVSAEEReGDVI---IRTFLLSNTNTVATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDL-----GNGPITVHCM
| |   |   |  |.   . |   .||    |  .  |        .| | || . || .. . |     .  ||  .   | ..      | || ||| 
ggeqfsiygngnevfgtysvel.veviqdpereiitrnirltfegetrditqyqyegwpdh.nipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

DGVTRSGLFCAIMSTIGKL
 || |.| ||. .  . ||
agvgrtgtfctavimmkkl

subfamily_CG42327_pd Subfamily CG42327 2393-2550 4.4e-20 66.6 In-house 29-187 (319) alignment
Range on Protein: 2393-2550
Range on HMM: 29-187/319.0
HHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNR-RDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAG----DEA
. |.|. . .|| . |. |    .. ...|..|... |..  .  |||.|..|. .  ||||.... .| ||| | ..  .  . |..|.|.     .. 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

LIGPFVIDVSAEEREGDVIIRTFLLSNtntVATESSRVIRQYSFvGWKERqKYPKSLASLLCLL
| | . . .   | .   .| |.|| .   |  | || .  | .  | |  . | . |.|...|
lyGdilvtlkgrevkdryaistlllkr...vdkeesrelthywy.kwlea.evPaeeaaliaml

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2098-2331 1.3e-19 64.7 In-house 47-282 (302) alignment
Range on Protein: 2098-2331
Range on HMM: 47-282/302.0
TRQENVSKNRYINIIPYDHSRVILDTDPDapheDYINASFVSGY-LKpKAYIATQGPLSTTV---FDFWRMVWQERVPVIVMLTKLVENKKrKCDPYWPE
. ..|..||.  ..  .|. .|.|.. ||    .|.||| |.   |. .  | .| | ....    .|||||.||..  .|.| .  | ||   . ..|.
afkknlkknqsedvpildsnlvkleaepd....syvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpk

DIETYGDFTLTVVAERNYLNYTERTLTIRKAWDPEER----RVQHFHYTSWPDMGLPLSATPLLEFITKVKEFEARPSGPTIVHCSAGVGRTGTYFTIDS
  ..| ..    |  |   .  | .        ||.      ..  . | |..   | . . | . ..|| . ..  . .|..    |.|| |. .|   
ksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

MMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
 ..   .... |. . |  .|..| ..|.. .|||..| |||
aveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2428-2512 2.5e-19 63.9 In-house 229-312 (440) alignment
Range on Protein: 2428-2512
Range on HMM: 229-312/440.0
LDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEInrNDQTCSQYWPAGDEA-LIGPFVIDVSAEEREGDVIIRTFLLS
..|. ... .|||||||. || ||||...||.   |.|||..  ||.||| |||    .  .||| .     |    | .||. | 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2142-2362 3e-19 64.1 In-house 25-243 (255) alignment
Range on Protein: 2142-2362
Range on HMM: 25-243/255.0
LKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFT-LTVVAERNYLNYTERTLTIRKAWD--PEERRVQHFHYT
.||.     .   | ||  |.... | .  |.|||. . |... ||. |.| . .    .. ..|.. ..  .   |||.|        . . |.|..|.
vkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysyk

SWPDMGLPLSATPLLEFItKVkefeARPSGPTIVHCSAGVGRTGTYFTIDSMMD---MS---AREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLE
 |..   |  |  .|. . ||    .| | . .||||.|.||. ..  ....     .|   .   ... | ..  .| || . ..|| |  |    .|.
GWieknaPelareilnil.kv....vrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

CLlcgytsVPTKTIVQYFTRLEQTNLHTKR
 .       | . . . .... .. ||...
lv......fpkgeleakyqeirksylharq

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2390-2628 3.8e-19 63.4 In-house 35-268 (281) alignment
Range on Protein: 2390-2628
Range on HMM: 35-268/281.0
SENHHKNRYPDNIPLDKYRPYLMT-GCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWPAGDEAL
  | .|||| .   ||  |  |      .  |.|. | ..     .  || || | . |  ||||||.. |.  |||| .. . | . |..|.|    . 
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

IGPFVIDVSAEereGDVIIRTFLLSNTNTVATESSRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAgqRdlgNGPITVHCMDGVTRSGLFCAIMSTIG
.    . || |      . .... .  |      .|.| .. .  | . |  |.|   .| .|  . |  |     |  .||  || ||| . |.  .. 
lqfdklsvsye...dstvnkslvttrlnlsyegetrlithwlwkewpdwq.vpessevmlkilrkira..r...stppvihcsagvgrsgtlmaveialq

KLKSEGNI-DVFHAVKKLRkCSGRM--VPSEEQYLYIHDVVREY
 ..|   . |. . | .||  .||   | . .||. |  |. ..
sihshftlpdikqivshlr.vtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2394-2632 6.7e-19 62.9 In-house 37-273 (285) alignment
Range on Protein: 2394-2632
Range on HMM: 37-273/285.0
HKNRYPDNIPLDKYRPYLMtgcsEGQTNYVNATFLDGFN-RRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN-RNDQTCSQYWPA--GDEALIG
  ||| |   ... |  |     . . .|. |...      .  ||.|| ||  |. |||.|||. .   ..||  .     . |. |.|   |.   .|
dlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

PFVIDVSaeEREGDVIIRTFL--LSNTNTVATESSRVIRQYSFVGWKERQKYPKSLASLLCLLDLVEAGqrDLGNGPITVHCMDGVTRSGLFCAIMSTIG
 . | ..  | . . |  | |  |. .||  . |  .  ..  | |   |  |.    .. |   |.    .  . || |||  || |.  |  |  .  
kyeitlt..eckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidyati

KLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASC
..  . ||...  |...|    . | |  |.|... |. ||.   
rimenpniemldivremramrfqavqshmqflflyvvlmeyfige

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2101-2335 1.1e-18 61.9 In-house 46-280 (303) alignment
Range on Protein: 2101-2335
Range on HMM: 46-280/303.0
ENVSKNRYINIIPYDHSRVILDtDpdaphEDYINASFVSGYLKPKAyIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPE--DIETY
.|. |||....|  |||.| |  |       || ||..    . || | || ||| |  |||.|. ...| ....|    | .|   |  .|.  |.  .
knmdknrfvdvicldhskvkls.d.....ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GDFTLTVVAERNYLNYTERTLTIRKAWDPEERRVQH-FHYTSWPDMGLPLSATP-LLEFITKVKEFE--ARPSGPTIVHCSAGVGRTGTYFTIDS-MMDM
 . .. |   ..       .| .    . . .   |  || .||   .|  ..| ..  | ... .     .| ||.    .|.||.||.  ...  . .
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
 . .  ....  .  .|  |.. ||   |. ..|  | | .|
hseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2098-2194 4.1e-18 59.8 In-house 44-156 (349) alignment
Range on Protein: 2098-2194
Range on HMM: 44-156/349.0
TRQENVSKNRYINIIPYDHSRVILDTDPDAPH--------------EDYINASFVSG--YLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVE
   |  .|||| .|.||.||||.|   . ...              .||||| ...   .   | ||||| || .|| ||....  ..|.... |..  |
eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

NKKRKCDPYWPED
.  .||| || | 
lslekcdiywqel

subfamily_egg_pd Subfamily egg 2382-2627 4.5e-18 60.0 In-house 30-268 (307) alignment
Range on Protein: 2382-2627
Range on HMM: 30-268/307.0
VSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEInRNDQTCSQYWP
.|..   |..| .| | .     |  |  |         ... |  ..|    . .| .| ||. ||.|||||..  . . ||||.   .. . |  |||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr.keserceyywp

AG--DEALI--GPFVIDVSAEEREGDVIIRTFLLSNtntVATEssrviRQYSFV-GWKERQKYPKSLASLLCLLDLVeagqRDLGNgPITVHCMDGVTRS
    | . .  | . |.    ... | . |   |     | ..     ..  |.  |.   ..   . | | .| ..    |.| . |. |....||...
kaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgd.....deerflehwqgdvnnssdvysplrvlrkl....rnlsk.pvvvqdilGvska

GLFCAIMSTIGKLKSE--GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVRE
. . ||  .. .|         | .||. ||.     | |  .||... .|  
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2518-2635 5e-18 59.7 In-house 273-390 (392) alignment
Range on Protein: 2518-2635
Range on HMM: 273-390/392.0
ATESSRVIRQYSFVGWKERQKYPK-SLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEE
.. .|  . || | ||       .    ||| |.  | .   .  .  | |||. |  |.|.||. |  | ..     .|.| .|| ||    ..| .||
slkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqtee

QYLYIHDVVREYLAScEIY
.| ...||.|||| . | |
eyafvydvireylht.eky

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2388-2625 5.5e-18 59.9 In-house 29-291 (297) alignment
Range on Protein: 2388-2625
Range on HMM: 29-291/297.0
KSSENHHKNRYPDNIPLDKYRPYLMTGCSEgqTNYVNATFLDGFNRR--DMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRND-QTCSQYWPAGD
| .   .|||| | .  |. |  |. . .|  ..|.|| ..   .      || .| ||. ||.|||..... . .||||. ... .  . |  |||  .
krnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

E--ALIGPFVIDV-SAEEREgdviIRTFLLSNTNTVATESSRVIRQYSFVGWKERQkYP---KS--------------LASLLCLLD--------LVEAG
.     | .|..  |    |      .  |.. . .  . |||.|   |..| .    |   .               .  .|.|..         .|. 
qerlkagdvvveflsstsde....fdrviltelqliyrsesrvvrhvqflswpdhG.vpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

QRDL-GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVV
. .   | .. |||  || |||.    .  . ||. .   ||   ...||.   |.| . ||. ...|.|
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2223-2331 1.6e-17 58.3 In-house 210-341 (350) alignment
Range on Protein: 2223-2331
Range on HMM: 210-341/350.0
KAWDPEErrVQHFHYTSWPDMGL---PLSATPLLE----FIT---KVKEFEARPSGPTIVHCSAGVGRTGTYFTIDSMMD----MSA---REQQINV---
 | || .  | ....  |.|..|   | |  . ||    .|      . ..   | | .||||||||||||. |.||..     ..    . ....|   
aasdPyv..vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak

-----LDFVYRMRTKRVKMVQTPEQYVFIYEALL
        | ..| .|..|||. .|..|||||||
trDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2517-2631 1.9e-16 54.4 In-house 83-196 (440) alignment
Range on Protein: 2517-2631
Range on HMM: 83-196/440.0
VATESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEE
..   ||...|| . || ..   ||  . .| ... |.  |   ||||. |||  |. |.|.  |. | . . |   .||.|  .. .|.   .|| . |
ingiesrtlkqyhyqgwpdk.gvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYLYIHDVVREYLAS
|| ..|..| | | .
qyafvheavlegllc

subfamily_hpo-7_pd Subfamily hpo-7 2154-2337 3.6e-16 53.9 In-house 43-230 (263) alignment
Range on Protein: 2154-2337
Range on HMM: 43-230/263.0
LSTTVFDFWRMVWQERVPVIVMLTKLVENKKRKCDPYWPEDIETYGDFT-LTVVAERNYLNYTERTLTIRKAWD--PEERRVQHFHYTSWPDMGLPLSAT
|  |.  |.... | .  |.|||.   |. . ||. |.| . .    .. ..|.. .   .   .|| . .  .   . . |.|. |. |..   |  | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLLEFITkVkefeARPSGPTIVHCSAGVGRTGTYFTIDSMMD---MS---AREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCG
  |. .  |    || | . .||||.|.||.  .  ....     .|   .   ... | ..  .| .| . ..|| |  |    .|. .|  
eilnilk.v....arnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2567-2629 6.8e-16 52.4 In-house 2-64 (69) alignment
Range on Protein: 2567-2629
Range on HMM: 2-64/69.0
VHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
|||  |  |.| | |||  . ..|||  .|.|  |. .|||   ||  |..|..||| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2566-2629 7.1e-16 52.4 In-house 2-65 (69) alignment
Range on Protein: 2566-2629
Range on HMM: 2-65/69.0
TVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYL
 |||  |  |.| | |||  . ..|||  .|.|  |. .|||   ||  | .|..||| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2439-2626 3.3e-15 51.0 In-house 64-256 (290) alignment
Range on Protein: 2439-2626
Range on HMM: 64-256/290.0
ATQMPLQ-------HTVEDFWRMIYDYNSNVIVMLNEINRNDQT-----CSQYWPA--GDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRV
.|| |..        |.|.|| |. . ... .||| | . ...      |..| |   |.|  .. . .     | | ||..|. ..   .    |    
ltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd....eeeft

IRQYSFVGWKERQkYPKSLASLLCLLDLVEAGqrdlgNGPITVHCMDGVTRSGLFCAIMSTIGKLK-SEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHD
.  . ..||....  ...  .|| |.. |.|      . |. |||.||. ||  . ||     |.  ..|.. .  ..|.|||    .. |.... ..  
vtHsllkgWnkln.vqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

VVR
.. 
giv

0048076 (Phosphotyrosine protein) phosphatases II 2519-2628 3.5e-15 51.4 In-house 41-142 (145) alignment
Range on Protein: 2519-2628
Range on HMM: 41-142/145.0
TESSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVEAGQRDlgNGPITVHCMDGVTRSGLFCAIMstI--GklkseGNIDVFHAVKKLRKCSGRMVPSEE
.  .| . || ...|  .   | .|. || .|...|. ...  .||. |||. || |.|...|..  .         ......|....|..   .||...
ellerlgiqylylpwpDh.gvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaay..lmll.....lgvsleealelvrsqrpgavpnpg

QYLYIHDVVREY
|. .......|.
qlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 2522-2623 7.5e-15 50.4 In-house 46-139 (144) alignment
Range on Protein: 2522-2623
Range on HMM: 46-139/144.0
SRVIRQYSFVGWKERQkYPKSLASLLCLLDLVEAGQRdlGNGPITVHCMDGVTRSGLFCAIMSTIgklksEGNIDVFHAVKKLRKCSGRMVPSEEQYLYI
 | . || ...|  ..  | .|. || .|...|. ..   .||. |||. || |.|...|.   .     . ......|.. .|..   .||...|. ..
eregiqylhlpwpDhg.vpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

HD
..
le

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2066-2152 7.8e-15 48.8 In-house 12-95 (95) alignment
Range on Protein: 2066-2152
Range on HMM: 12-95/95.0
GYVKEKTANGEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDApheDYINASFVSGYLKPKAYIATQG
 .| |  .| .  |  ..  ..     .. | . . |. |||..||.||| .||.| |  |.   ||||| || || . ..|||.||
shvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrds...dyinacfvdgyarkncyiaaqg

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2390-2484 3.1e-14 47.5 In-house 45-154 (350) alignment
Range on Protein: 2390-2484
Range on HMM: 45-154/350.0
SENHHKNRYPDNIPLDKYRPYLMTG--------CSEGQTNYVNATFLDGF-----NRRDM-YIATQMPLQHTVEDFWRMIYDYNSNVIVMLNE-INRNDQ
 |   |||| . .| .. |  |  .         |    .|.|| .|           |  ||||| ||. ||.||...|.  . .||..|.. .. | .
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

TCSQYWPAGD
 | .||. |.
kcyrYWqegs

fn3 Fibronectin type III domain 1681-1770 3.2e-14 46.0 Pfam-A 2-82 (85) alignment
Range on Protein: 1681-1770
Range on HMM: 2-82/85.0
PVTELQVLNRTLDSIELRWEAPKSLNGELLGYTISYVPVVKNEpkdgnlstkrPVMNIHNTRST-HILVSELDPATEYIFRISANNRVGDG
... |.| ..| .|..|.|..||. .|.. ||.. | .. ..|          .  .....|.| .  ...| | ||| ||. | |..| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngageg

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2101-2199 9.6e-14 45.6 In-house 33-129 (332) alignment
Range on Protein: 2101-2199
Range on HMM: 33-129/332.0
ENVSKNRYINIIPYDHSRVILdtDPDAPHEDYINASFVSGYLKPKAYIATQGPLS-TTVFDFWRMVWQERVPVIVMLTKLVENKKRKCdPYWPEDIETYG
.|.  ||   .  .||||| |   |.  ..|. |||.| || |  ||| .| |.   | . ||||| . .  .|...  . |..|||. ||   |     
nnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka.pydisdrgfek





subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2384-2483 9.7e-14 45.6 In-house 88-181 (244) alignment
Range on Protein: 2384-2483
Range on HMM: 88-181/244.0
MQAGKSSENHHKNRYPDNIPLDKYRPYLMTGcSEGQTnYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDqtcsQYWPAG
|.   . .| .|||    .|.|  |  |  | | |.| |.||.|.  . |   || || ||  |  |||.|. .   ||.|.|  .. .|    .|||  
mkdafnpnnswknregaglpfdfnrvplskg.smgnt.yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpds





subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2395-2636 3e-13 44.1 In-house 46-283 (312) alignment
Range on Protein: 2395-2636
Range on HMM: 46-283/312.0
KNRYPDNIPLDKYRpYLMTGcseGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWP-------AGDEA
 ||||.    |. | . ..|    .  |. | |.    . . ...|| ||. |.  ||..     |  |..|  . .   . |..|           |  
lnrypniqcwdrgr.ftlag...denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

LIGPFVIDVSAEEREGDVIIRTFLLSNTNTVATESsrVIRQYSFVGWKERqKYPKSLASLLCLLDLVEagqRDlgNGPITVHCMDGVTRSGLFCAIMSTI
.   .. ..    .  | |    |    ..   ||   . .| .  | .    | |  . | ||  |    .|  . |.  ||  || |.| .. | | |
vyteycteieiggkskdkithrvlkvvvkatgqes..klnhyqwaswpdh.gmpdscdtalrllsavk...kd..kkpviahcsagvgrtgtlaliesmi

GKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLASCEIYE
  |.   . .| ..   |||   | |    ||.|   .| |.| |  .|.
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2437-2585 3.9e-13 44.1 In-house 37-171 (255) alignment
Range on Protein: 2437-2585
Range on HMM: 37-171/255.0
YIAtqmplqhTVEDFWRMIYDYNSNVIVMLNEINR-NDQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVaTESSRVIRQYSFVGWKE
|.        ||. |...|   ...|.||| . .  . . ||.|.|   .       ..|.. .   ||..||  .  | .      . .. ||. || |
ysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWie

RqKYPKSLASLLCLLDLVEAGqRdlgngPITVHCMDGVTRSGLFCAIMST
. . |.    .| .| .|    .     .. |||  |. ||  |  . . 
k.naPelareilnilkvvrds.k.....svvvhCstGiGrsaafvlaelv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2131-2244 6.5e-13 42.9 In-house 123-234 (244) alignment
Range on Protein: 2131-2244
Range on HMM: 123-234/244.0
DYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENkkrkcDPYWP--EDIETYG-DFTLTVVAERNYLNYTERTLTIRKAWDP
 |||||||    .   || || ||. | .|||.|. .  | |.|.|  . |.     | |||  | .| |  | |.|.    .. |     | |    . 
tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmne

EERRVQHFHYTSWPDMG
  . .  |  . ||  |
shqaltmfqisnwpsdg

fn3 Fibronectin type III domain 1579-1667 7.5e-13 41.6 Pfam-A 1-85 (85) alignment
Range on Protein: 1579-1667
Range on HMM: 1-85/85.0
PKPTGLEVLEIGETNVTLQWVRPNPPHGIIHEYKLQFWRQSEMRsnQSIEITiRSEDEKvNGTLIGLNPFTAYVIKIRGVTSAGPGDWS
..|..| | |...|..||.|  |....| |  |..... .....  .. |.| ...... . || ||.| | |..... |. || | .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeft.vprttt.svtltgLkpgteYefrVqavngagegpeS

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2139-2221 7.6e-13 42.6 In-house 230-311 (440) alignment
Range on Protein: 2139-2221
Range on HMM: 230-311/440.0
SGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLveNKkRKCDPYWPEDIE--TYGDFTLTVVAERNYLNYTERTLTI
 || | .|.|||| || .||.||||.| . |.  |.|| .|  |  . |  ||| .    |.| ||.      |      ||| .
egyskknafiatqmpldstvldfwrlvhdyristiimlnql..nd.ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel

subfamily_CG42327_pd Subfamily CG42327 2267-2331 1.1e-12 42.3 In-house 247-312 (319) alignment
Range on Protein: 2267-2331
Range on HMM: 247-312/319.0
SGPTIVHCSAGVGRTGTYFTIDSMMDM-SAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALL
 || .|||| ||||||.  . |  .      .. ... . |. .|  | . |.| ||| |||  | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2271-2336 4.4e-12 40.2 In-house 2-67 (69) alignment
Range on Protein: 2271-2336
Range on HMM: 2-67/69.0
IVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLC
.||||.| |||||. .|   |     |. ..... |  ||  |  ||    .|.||..|| | |  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl

subfamily_hpo-7_pd Subfamily hpo-7 2433-2584 5.7e-12 40.1 In-house 36-176 (263) alignment
Range on Protein: 2433-2584
Range on HMM: 36-176/263.0
RRDMYIAtqmpLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWPAGDEALIGPFVIDVSAEEREGDVIIRTFLLSNTNTVaTESSRVIRQYSFV
|...|.     |  |.. |...|   ...|.||| . | .  . ||.|.|   .       ..|.. .   ||...|  | .|        . ...||..
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.Kkkthtvkhysyk

GWKERQkYPKSLASLLCLLDLVEAGqRdlgngPITVHCMDGVTRSGLFCAIMS
|| |..  |.   . | .|...    .     .. |||  |. ||  |  . .
gWiekn.dpelareilnilkvarns.k.....slvvhcstGiGrsaafsvaEl

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2112-2244 9e-12 39.4 In-house 3-125 (130) alignment
Range on Protein: 2112-2244
Range on HMM: 3-125/130.0
IPYDHSRVIldtdpdapHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVMLTKLVENkkrkcDPYWPE--DIETYG-DFTLTVVAE
.... ||.          ..|||||||    . . |. || ||. |  |||.|. .  | |.|.|  . |.     | |||.   .| |  | ..|.   
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

RNYLNYTERTLTIRKAWDPEERRVQHFHYTSWPDMG
 .. |     | | .      . .  |. . ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg

fn3 Fibronectin type III domain 1387-1469 9.9e-12 38.0 Pfam-A 9-84 (85) alignment
Range on Protein: 1387-1469
Range on HMM: 9-84/85.0
TSDNPTSIRLNWNAPPNQKCPINSYVVSYRLVRQDRclldddwPTHELAVVANHGDVEIDSLIPFSTYELKVFAVTEAGNGSM
.. ..||..|.|..|.... || .| | || ... .       ...|  | ...  |..  | | ..||..| ||..||.|  
sevtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2271-2337 1.3e-11 38.7 In-house 1-67 (69) alignment
Range on Protein: 2271-2337
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTYFTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLLCG
.||||.| |||||. .|   |     |. ..... |  ||  |  ||   ..|.||..|| | |  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2062-2140 1.9e-11 38.0 In-house 9-85 (440) alignment
Range on Protein: 2062-2140
Range on HMM: 9-85/440.0
VELSGYVKEKTAngEMCFKLDYERLPDGQMYTWEVATRQENVSKNRYINIIPYDHSRVILDTDPDAPHEDYINASFVSG
.... ||...       |. ..  || | .   ..|.  .|  |||| ||. ||||||.|.     |..||||||...|
adfadyvqnnrr..srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

fn3 Fibronectin type III domain 669-751 2.1e-11 37.0 Pfam-A 1-85 (85) alignment
Range on Protein: 669-751
Range on HMM: 1-85/85.0
SAPSAVEVIDLSTDSVTLSWGEVPcgHRKGLISNYLLMLRGAQQG----TQIVSASQHSYTFPDLAECFMYNFTVAAHNMAGVGPTS
|||. . |.. ...|.|||| . .  ...| |..| . .| ...|    .. |.....|.|...| .   |.|.|.|.| || ||.|
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 1484-1566 2.2e-11 36.9 Pfam-A 2-85 (85) alignment
Range on Protein: 1484-1566
Range on HMM: 2-85/85.0
APDAITVDLVTSREIEFSWREPPcgTRHGDIVHYEYQLLDA--KN-DRTLMATTTETVVQIGFLTPYTEYRFSVRAASLKGYGPFS
||  ..|. |||.....|| .|.  ...|.|..|| .. ..   . ...  .. |.| |..  |.|.|||.|.|.| . .|.||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 766-853 3.5e-11 36.3 Pfam-A 2-84 (85) alignment
Range on Protein: 766-853
Range on HMM: 2-84/85.0
PVPNLRVTS-TPTEIHLSWDPP-VQSACQMEYIVRYTPQVLDQciaqltegPIVAGNTNL-TTDFTIAGLVPYSTYSVEVLARNSIGFGVP
.. ||.|.. |.|...|||.||  ...    | |.| ..   .        . .  ..   || .|. || |...|...| |.|  | | .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2262-2332 8.7e-11 35.7 In-house 260-342 (349) alignment
Range on Protein: 2262-2332
Range on HMM: 260-342/349.0
FEARPSGPTIVHCSAGVGRTGTYFTIDSMMD-MSAREQQINVLDF-----------VYRMRTKRVKMVQTPEQYVFIYEALLE
...  . . .|||||| ||||.. |.|.... ..  ... | ...           |  .| .|. |||   |...||||||.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

fn3 Fibronectin type III domain 1169-1255 1.4e-10 34.3 Pfam-A 2-79 (85) alignment
Range on Protein: 1169-1255
Range on HMM: 2-79/85.0
PVTSLNLQTLSSAEMNITWSPPAAQPCPIVSYGLRYLPTNTDQcdatirrltATRTSDVETQNTSAVVSGLLPFTTYRVMVWARTDA
... |..   .| .....||||. .  ||..| ..| .... .         .... .|. . ||....|| | |.|.. | |...|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 1288-1364 1.6e-10 34.1 Pfam-A 12-85 (85) alignment
Range on Protein: 1288-1364
Range on HMM: 12-85/85.0
KPTKLNVSWEEVPcgHRCGDITFYAYELEALEDSAlNSKTSKIPASHRYVTLDDLEPCEVYQFRVRARTRKGWGPFS
 .|.|..||.. .  .. |.|| |  |..  ...   .|. ..|.... ||| .|.|   |.|||.|....|.||.|
tstsltlsWsppk..dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2100-2176 2.9e-10 34.2 In-house 35-116 (347) alignment
Range on Protein: 2100-2176
Range on HMM: 35-116/347.0
QENVSKNRYINIIPYDHSRVILDT-----DPDAPHEDYINASFVSGYLKPKAYIATQGPLSTTVFDFWRMVWQERVPVIVML
. ..||||  .    | .||.|        .  . | ||||| .      | || || ||  || |||.||   .|  .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_CG42327_pd Subfamily CG42327 2561-2630 5.3e-10 33.4 In-house 246-316 (319) alignment
Range on Protein: 2561-2630
Range on HMM: 246-316/319.0
GNGPITVHCMDGVTRSGLFCAIMSTIGKLKSE-GNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 .||..||| ||| |.||  |   .| .|.     .|. . |  .|.  .. | . ||| .|. |. || .
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

fn3 Fibronectin type III domain 868-950 5.9e-10 32.3 Pfam-A 3-83 (85) alignment
Range on Protein: 868-950
Range on HMM: 3-83/85.0
VTQLTLVETTEDSISLTWDLPCgQTHGGILLFHYELSNENVPIaALTEGDSPRNATSLTINNLASCTPYEFRIKAKTSAGYGR
...|.. |.|..|..|.|. |  . .| |  .  |..... .  . .| . ||..||.|...|   |.||||..| . ||.|.
PenlsvsevtstsltlsWsppk.dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_eak_pd Subfamily eak 2382-2537 1.7e-09 31.6 In-house 42-193 (332) alignment
Range on Protein: 2382-2537
Range on HMM: 42-193/332.0
VSMQAGKSSENHHKNrYPDNIPLDKYRPYLmTGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML-NEINRNDQTCSQYW
 |.. ..  |. ..|   . .| |.|   | | .   .  |.||. ..  .    || | .. .  |  ||.|... .|  ||.| .... . .   .|.
lsisetarleavnrn.vvkivpydrylvrl.tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PAG--DEALIGPFVIDVSAEEREGDVIIRTFLLSNTNtvatESSRViRQYSFVGWKERQ
|    .|   | . ..     ... .  | . ||  |    |. ||   | . || | .
pdktreelkfGildverkefvkrniletrllelskGn....ethrv.lhykvfGwtett

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2388-2466 2.2e-09 31.3 In-house 43-114 (303) alignment
Range on Protein: 2388-2466
Range on HMM: 43-114/303.0
KSSENHHKNRYPDNIPLDKYRPYLMtgcsegQTNYVNATFLDgFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVML
.  .| .|||. | | ||. .  |       .. |. |..|. .. .   | ||.||.||  |||.|| . . .....|
qfvknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll

fn3 Fibronectin type III domain 981-1054 2.3e-09 30.5 Pfam-A 15-80 (85) alignment
Range on Protein: 981-1054
Range on HMM: 15-80/85.0
EADVTWSPPEVNGCPILYYRVTYVLTNLGMcgpissSLRMFRfAGNTSHwFIRLSNLEPYSTYDVYVQAVSDAG
.. ..||||. .| || .|.|.|  .. |         . |. . .|..    |..|.|...| . ||||..||
sltlsWsppkdgggpitgYeveyrekggge......ewkeft.vprttt.svtltgLkpgteYefrVqavngag

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2417-2628 2.9e-09 30.8 In-house 72-284 (302) alignment
Range on Protein: 2417-2628
Range on HMM: 72-284/302.0
EGQTNYVNATFLDGF--NrRDMYIaTQMPLQHTV---EDFWRMIYDYNSNVIVMLNEINRNDQTCSQYWP--AGDEALIGPFVIDVSAEEREGDVIiRTF
. . .||||. ..    . | ... .|.| . ..   |.||||... .   .|.|   .  ..| |...|  .||    | . . .   |.  .     .
aepdsyvnaskvevPelt.rsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.try

LLSNTNTVATEsSRVIRQYSFVGWKERqKYPKSLASLLCLLDLVeAGQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSG
 .       .. | ..  | .  ||.  | |.. |.|      |   .   .. .. .  . |. | | | . . .. ||... .  .   ||..|.   
viEvlPegcsn.svlanvyvltnWkqk.kvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRp

RMVPSEEQYLYIHDVVREY
|.| | .||  .. ..  |
ravdslkQyvslyiallly

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2417-2483 5.2e-09 29.9 In-house 87-156 (349) alignment
Range on Protein: 2417-2483
Range on HMM: 87-156/349.0
EGQTNYVNATFLD--GFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRN-DQTCSQYWPAG
    .|.|| .|    ..    |||||.||  ||.||...|   . .... ||. . .  . | .||  .
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2439-2622 6.6e-09 29.6 In-house 95-281 (302) alignment
Range on Protein: 2439-2622
Range on HMM: 95-281/302.0
ATQMPLQHTVEDFWRMIYDYNSNVIVMLNEI-NRNDQTCSQYWP--AGDEALIGPFVIDV-SAEER------EGDVIIRTFLLSNTNTVAtESSRVIRQY
   .| . |.| .| .| .||  ..| | .. . ... |..|.    |.|   | . .   | ..         .. . |  . |...   .  . .   
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdil

SFVGWKERQkYPKSLASLLCLLDLVEAGQRDlgngpITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIH
 | .| .    ||   . | .|   |. ...     . |||  || |.| . ||   |   . .   |. . |. .|.|    | .|.| .|. 
afsawpdhG.apkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2420-2503 7e-09 30.1 In-house 13-92 (130) alignment
Range on Protein: 2420-2503
Range on HMM: 13-92/130.0
TNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEINRNDqtcsQYWPAGDEALIGPFVIDVSAEEREGD
 .|.|| |.   .|   |. || ||  |  |||.|. .   ||.|.|  .. .|    .|||  .        | |.  .|.. 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdef

0038934 (Phosphotyrosine protein) phosphatases II 2222-2322 1.1e-07 27.2 In-house 67-165 (194) alignment
Range on Protein: 2222-2322
Range on HMM: 67-165/194.0
RKAWDPEERRV--QHFHYTSWPDMGLPLSATPLLEFITKVKEFEAR-PSGPTIVHCSAGVGRTGTyFTIDSMMDMsareQQINVLDFVYRMRTKRVKMVQ
 . .||||      ...   .|| | . |   ||.|.  |.|| .. |.|   ||| ||.||||| . .  .. .    ..... . ....| || ....
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGt.lvaaYLiyr....lgmsaeeAialfrekRpgaip

TPEQ
....
nqdy

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2388-2475 1.1e-07 25.7 In-house 30-116 (332) alignment
Range on Protein: 2388-2475
Range on HMM: 30-116/332.0
KSSENHHKNRYPDNIPLDKYRPYLMtgCSEGQTNYVNATFLDGFNRRDMYIATQMPLQ-HTVEDFWRMIYDYNSNVIVMLNEINRNDQT
|  .|   || |    .|. |  |     .|. .. ||...||....  || .| |.. ||   ||||. . . ..|... .|. ... 
kflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2380-2441 2.1e-07 25.0 In-house 36-94 (95) alignment
Range on Protein: 2380-2441
Range on HMM: 36-94/95.0
SDVSMQAGKSSENHHKNRYPDNIPLDKYRPYLMTgcsEGQTNYVNATFLDGFNRRDMYIATQ
|  .  .| |  |  |||. . .| |  |  | |     ...|.|| |.||. |.. |||.|
sgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2413-2470 3.5e-07 24.1 In-house 63-120 (347) alignment
Range on Protein: 2413-2470
Range on HMM: 63-120/347.0
TGCSEGQTNYVNATFLDGFNRRDMYIATQMPLQHTVEDFWRMIYDYNSNVIVMLNEIN
.. ..   .|.||. .   | .  || || || .|| |||.|..  .   .| . |  
nsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi

subfamily_eak_pd Subfamily eak 2264-2335 4.2e-07 23.7 In-house 233-306 (332) alignment
Range on Protein: 2264-2335
Range on HMM: 233-306/332.0
ARPSGPTIVHCSAGVGRTGTYFTIDSMMDMSA--REQQINVLDFVYRMRTKRVKMVQTPEQYVFIYEALLECLL
. ||   |. .. |  |.|..  || .. .    ..    | |.. ....||.. | .  |. ||||..|. ||
tppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_PTEN_pd Subfamily PTEN 2252-2327 7.4e-07 24.3 In-house 98-175 (184) alignment
Range on Protein: 2252-2327
Range on HMM: 98-175/184.0
LLEFITKVKEF-EARPSGPTIVHCSAGVGRTGTYfTIDSMMDMSAREQQINVLDFVYRMRTKRVKMVQTPEQYVFI--Y
| |........ |. ..   .||| || ||||.  ..  .. .   |.. ..|..  ..|||  | |. | |  ..  |
leeivediekwleedkknvvvvHCkaGkGRtGvl.ivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy

hEGF Human growth factor-like EGF 239-251 9.1e-07 17.6 Pfam-A 1-13 (13) alignment
Range on Protein: 239-251
Range on HMM: 1-13/13.0
ECVCPPGFTGQLC
.|.||||.||. |
tCqCppGyTGpnC

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2440-2630 1.5e-06 21.1 In-house 123-310 (346) alignment
Range on Protein: 2440-2630
Range on HMM: 123-310/346.0
TQMPLQHTVEDFWRMIYDYNSNVIV-MLNEINRNDQTCSQYW-PAGDEALIGPFVIDVSAEEREGDVIIRTFL-LSNTNtvateSSRVI-RQYSFVGWKE
 ||  .  ||||| |||. . ...  |. . . .. | | .    |     | ..|.    .  ||    |   | . |     |  || . .    || 
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegn.....sdsvicqvhhhapwkh

RQKYPKSLASLLCLLDLVEagQRDLGNGPITVHCMDGVTRSGLFCAIMSTIGKLKSEGNIDVFHAVKKLRKCSGRMVPSEEQYLYIHDVVREYLA
 |. ||.|  .  . ..    .... |  . |  . |  |.  |   . .| .|    . ...  .|....     | |  ||  |. .| .|.|
lqqppktlpiikmihqfls..ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia

fn3 Fibronectin type III domain 461-539 2.8e-06 20.6 Pfam-A 6-80 (85) alignment
Range on Protein: 461-539
Range on HMM: 6-80/85.0
PTIVTVNSDAVELAWNAWNaavdTGSGPVTAYIVQSREHGVAAWETAGNVTEGPFTFTVMSLGSRITYDFQVVAVRPGL
...  |.|. ..| |.. .    .|.||.| | |. || |   ...  .|..   ..|.  |    .| |.| ||  . 
lsvsevtstsltlsWsppk....dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag

subfamily_PTPDC1_pd Subfamily PTPDC1 2234-2326 3.7e-06 21.5 In-house 84-168 (182) alignment
Range on Protein: 2234-2326
Range on HMM: 84-168/182.0
HFHYTSWPDMGLPlSATPLLEfITKVKEFEARpSGPTIVHCSAGVGRTGTYftIDSMMDMSareQQINVLDFVYRMRTKRVKMVQTPEQYVFI
 ..  .|.| | . | . .|. | || .|  .  | . ||| || ||||    | ...  .   ....  . .  .| || | .|| ||  ..
yvynfgwkDygva.sleriLd.ivkvvafalq.egkvavhChaGlGrtGvl..iacylvya...krltaekaiklvrskrpksiqtreqvelv

fn3 Fibronectin type III domain 1073-1155 6.5e-06 19.4 Pfam-A 6-85 (85) alignment
Range on Protein: 1073-1155
Range on HMM: 6-85/85.0
VMVVDVmerTQSSLKFRWNTLEcgDRHGPEVIYHYRLESPSGL-YWNGQVHDPES-LAAVYGLLPCLMYSFKVQAETSAGFGEPS
. | .|   | .|| ..|.  .  |..|| . |  .... .|  .|. .  .. .  . . || |   |.|.||| . || |..|
lsvsev...tstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 561-644 8.1e-06 19.1 Pfam-A 3-73 (85) alignment
Range on Protein: 561-644
Range on HMM: 3-73/85.0
IPSLSVSSIpnKSTSLLVTWEPTLERRCDVAYYIIHYditrfD-----QcadrkatsgsdVSQSGTFNTTETSWTINGLNEYSSYVVFV
.  ||||..   |||| ..|.|  ... .. .| ..|           .           .... |   |.|| |..||.....|.. |
Penlsvsev..tstsltlsWsppkdgggpitgYevey.....rekggge...........ewkeftvprtttsvtltgLkpgteYefrV