Gene SpurPTPRB-like-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTPRB-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP111_AA protein Get Run
SpurP111_AA_1947-2223 phosphatase_domain Get Run
SpurP111_AA_2239-2512 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1943-2359 3.8e-141 466.5 In-house 2-416 (564) alignment 
Range on Protein: 1943-2359
Range on HMM: 2-416/564.0
HEPIHISNLAKVIKAKRMSRD-GFEKEYKALLNKSDEGC-IGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNA
..||....|.. ..  ....|  ||.||| . ... . .   |.|.||.||||.||. ||. ||.|.|.. ..| |||||.|||||.|..|.||.||| |
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGnHKRYGELEVIAREVKDEGSYVLRKFEVgKPDRTTNRLNITQYHYTIWPDMGVPESSQPL
 ...|||.||.||..|||||||.| ||.|.|| .|||. | ...||||.|   | ..   |..|.|.. |  .. .  ...|.|.| ||| ||||| ..|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKT
||... |...|. |.|||.||||||||||||||.|..|.| |..||..|........|| | .||| ..|| ||.|..|.  .| . . .. .| .... 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

WGTIKDADGRTEMSRQFEVLEYMAPMEsTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDF
  ....  . |.... |. |.   ..| . . . .  |.| ||||... ..... .  | .  .  .. ||||||...   .|. .. || ||  || ||
LaeveedtemtgleleFqrLatakeie.leefavatkpknkkknrfsnilalescrvvlsaira.keesdyinasyleayrekrafiatqaplkntvedf

WRLVWDYDIHTIIHLNEMD
||.||......|. |....
wrmvweeevkiivmltkle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1943-2221 3.5e-136 447.9 In-house 1-278 (288) alignment 
Range on Protein: 1943-2221
Range on HMM: 1-278/288.0
HEPIHISNLAKVIKAKRMSRDGFEKEYKAL--LNKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNA
.||||||..|||.|.....|.||..||..|  |.|......|....|..||||.||..|||.||||.||..|.|||||||..|||.||....||.|||.|
sepihispvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPla

ASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIAREVKDEGSYVLRKFEVGkpdRTTNRLNITQYHYTIWPDMGVPESSQPL
...||||..|||..||||||||.|.|..|.||.||||.|...|.||...|...|.|.....||||....   .....|.||||.|..|||.|||||..||
dtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapl

LDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
|.....||.||.||.||||||||||||||||||.....|...|.|..|||.......||.||..||...|||||||.||. 
lellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2239-2518 2.7e-111 366.2 In-house 9-288 (288) alignment 
Range on Protein: 2239-2518
Range on HMM: 9-288/288.0
KTWGTIKDADGRTEMSRQFEVLeymAPMESTGSDQKGSLPVNAKKNRYPDRVPVDkFKPLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVG
 .....|.|..||..|.....|   |..|.| |...|.|.||||||||....|.| .|.. ..|..|....||||||..|.|..|.....||.||..||.
vakvakksarnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

DFWRLVWDYDIHTIIHLNEM----DSTCGQYWPDSDK-TNFGSFTIELLSDRTLTDTMTERVLKVttsKKKGERQITQLQYLGWPNDSlVPRSKMDFFEL
|||.||......||..|.|.    ...|..||||.|| .|.||.|..|.....|.|......|..   |||.|..|||.|||.||... ||.||....||
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhg.vPeskapllel

LTQVDNNNTSE-KKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLA--AYQDSVQTYA
|.||...|... ....|.|..|||...||.|..|.||.|.|....|....|..|||.|. .|..|..|||.|.||.  ...|.|...|
lrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgvaeva
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1946-2259 1.9e-99 327.7 In-house 2-317 (318) alignment 
Range on Protein: 1946-2259
Range on HMM: 2-317/318.0
IHISNLAKVIKAKRM-SRDGFEKEYKALLN--KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAAS
|....|.. ..  |.  .  ...||..|    ..      ..| || |||| ||..||. ||||..| .|.|.||||| .||||....|.||.|.| .  
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

LNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNhKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRlNITQYHYTIWPDMGVPESSQPLLD
..|||.||.|| ...|||||.. |. |.|.  |||| |  . ||.| | ..| .. ..||||.|.| . .   .| .. ||||| ||| |||||.  |||
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgaslld

FRDIVKNAN-PADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTW
.   |..|. ... |||.|||||||||||.||... ..| |.||. .|||......|..|  |||...||||||..||.  .. .   .  || . ..  
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

GTIKDADGRTEMSRQFEV
   .   |.|||  .|. 
reqdpesgttemdaefqr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1944-2257 2e-91 301.4 In-house 3-318 (319) alignment 
Range on Protein: 1944-2257
Range on HMM: 3-318/319.0
EPIHISNLAKVIKAKR-MSRDGFEKEYKALLNK-SDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAA
..|.. .|.. .|| .  .  ..|||.| | .  .|.    ...|||.||||.||..||  ||.| .|.  .|.|||||.|||||.....||| |.| . 
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

SLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAgNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLL
 ..|||.||.|...|..||||.| || | |. .|||.. |...||.| |   | .    |. ||... |     .  ......|| ||| .|||... ||
tiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

DFRDIVKNANPA-DSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKT
|.   ....    .||||.||||||||||||||... |.| .. |  .|||......|  | .||| ..||.||||.||.. .. .  . . || . .|.
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

WGTIKDADGRTEMSRQF
    .   | | ..|.|
laekvadtgetgleref
0050432 (Phosphotyrosine protein) phosphatases II 1941-2223 2.1e-91 301.7 In-house 21-300 (308) alignment 
Range on Protein: 1941-2223
Range on HMM: 21-300/308.0
PQHEPIHISNLAKVIKAkRMSRDGFEKEYKALLNKSDEGC--IGNNPENKPKNRYKNIITYDEHRVKLnklptEPGADYINATFIDGY--KKENAFIASQ
. ...... .|.| ..   ... ..|.|...||.. . .   ... ||||.|||||.|. ||  ||||     ..| ||||| ..|||  |....||| |
vsslklsvldllkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatq

GPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSA--GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTtNRLNITQYHYTIWPDMGVP
||   ...|||.||.||....|||||.| |....|| .|||.   |. ..|| . |  .... ...|..|..|. . .   . . .|..||| |||.|||
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvP

ESSQPLLDFRDIVKNANpaDSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
.| ..|||| ..|.. .  ..|||.||||||||||||||.. ...|..|.|...|||. .. .|..|..|||  .||.|.|..|| . .
pspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0051299 (Phosphotyrosine protein) phosphatases II 1954-2221 2.3e-91 301.5 In-house 13-285 (288) alignment 
Range on Protein: 1954-2221
Range on HMM: 13-285/288.0
VIKA-KRMSRDGFEKEYKALLNKSDEG--CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMV
.... .. .  |...|...||..   .   ... |||..||||..|. ||  ||||. |. ..| ||||| .||||.....||| |||   ...|||.||
lvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

YEQRTSTIVMLTNLLEKDKKKCIEYWPSaGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPD---RTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIV
.||....|||||.| |....||  |||. |... ||.. |  .... ...|..|..|| . |    . . ...|..||| |||.|||.| ..||||  .|
weqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

KNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
..|.....||..||||||||||||||.. ...|..|.|...||..... .|..| .|||  .||.|.||.|| .
rkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_PTPRB_pd Subfamily PTPRB 1943-2221 6.2e-91 299.5 In-house 4-284 (293) alignment 
Range on Protein: 1943-2221
Range on HMM: 4-284/293.0
HEPIHISNLAKVIK-AKRMSRDGFEKEYKAL--LNKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPN
..||....... .|  |. |  .| .||. |  ..|. .  . ....|. ||||.||..||. ||||..| .|.|.||||| .|.||. .. |||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIAREVKDEGSYVLRKFEVGKpdrTTNRLNITQYHYTIWPDMGVPESSQP
  ...|||.||.|...|.|||||.|.|| |.|| ||||.  .   ||...|   . ..   .|.|.... |   .... ...|||.| ||| ||||....
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektkt

LLDFRDIVKNAN--PADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
||||   |..|    |...||.||||||||||||||... ... || |  .|.| .. |.|..|...|| ..|| ||....|. 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_PTPRA_pd Subfamily PTPRA 1942-2237 6.4e-91 299.7 In-house 10-310 (330) alignment 
Range on Protein: 1942-2237
Range on HMM: 10-310/330.0
QHEPIHISNLAKVIKAkRMSRD--GFEKEYKALLNKSDEG--CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQG
.. |. . .| . |.  |.. |   | .|..||   . ..   . .. ||| |||. ||. ||  || |...  .. .|||||.||||||. . |||.||
kyfplpvekleeeiri.rsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

PNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHkRYGELEVIAREVKDEGSYVLRKFEVG-KPDRT--TNRLNITQYHYTIWPDMGVP
| . ...|||.|..||...||||||.| |....||  |||. |    ||.. |  ....   .| .||| |  .|| |   .   ..|.|.| |||.|||
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

ESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDL
  .. .|..   ||. |.  .|||.||||||||||||||... ..|...||.|.|||.|....|..|. ||| ..||||||..||..     . . .. |
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssl

PTT
 . 
ekh
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1946-2224 2.7e-89 294.4 In-house 12-292 (298) alignment 
Range on Protein: 1946-2224
Range on HMM: 12-292/298.0
IHISNLAKVIKAKRMSrdGFEKEYKALLNKSD-----EGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNA
.....||.| |.|...  |...|.. | . |.     |  ....|||| |||| .||..|  || |.|  ..  .|||||.|...||..|||||.|.|  
aalqklaavkkkkklt..gyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt

ASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNhKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTtNRLNITQYHYTIWPDMGVPESSQPL
....|||.|| |.  .|||||||| |.|| |. .|||. |. ..|||..|  .. .. . .. ||..| | ... .. .. | |.| ||| |||| .. .
etvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsv

LDFRDIVKNaNPADSG--PIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHC
||... |.  .. ..|  |.||.|||||||.|||| |. ..| ...|...|||. .. .||.|. .|| ..|| ||||  |.  ..
ldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
0046845 (Phosphotyrosine protein) phosphatases II 1964-2223 7.5e-89 293.1 In-house 1-275 (284) alignment 
Range on Protein: 1964-2223
Range on HMM: 1-275/284.0
GFEKEYKALLNKSDEG----CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTE-PGADYINATFIDGY-----KKENAFIASQGPNAASLNDFWQMVYEQ
|.|.|...||.          ... |||. |||||.|. ||  ||||. |. . .. ||||| ..|||     .....||| |||   ...|||.||.||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANP-
....|||||.| |....||  |||. |. ..||.. |  .... ...|..|..|. . . | . . .|..||| |||.|||.|...||.| ..|..... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-ADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEK---KIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
  ..|||.||||||||||||||.. ...|..|.|.   ..||.. .. .|..| .|||  .||.|.||.|| .  
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 1959-2254 1.1e-88 292.8 In-house 14-308 (317) alignment 
Range on Protein: 1959-2254
Range on HMM: 14-308/317.0
RMSRDGFEKEYKALLNKSDEG-CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTST
...  ....|.. ||. . .   ... ||||.||||..|. ||  ||||. |.  .. ||||| ..||... ..||| |||   ...|||.||.||....
ksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLTNLLEKDKKKCIEYWPSaGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPdRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGP
|||||.| |....|| .|||. |. . ||.. |  .... .....||..|| .  .. . . .|..||| |||.|||.| ..|||| ..|..|.. ..||
ivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggp

IIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTWGTIKDADGRTEMS
..||||||||||||||.. .|.|..| |...||.. ..|.|..|. .||  .||.|.|. ||..  .  .. .. .|.. .. . ...  |. ... 
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1945-2236 6.6e-88 289.8 In-house 3-297 (305) alignment 
Range on Protein: 1945-2236
Range on HMM: 3-297/305.0
PIHISNLAKVIKAKRMSRD-GFEKEYKALLNKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASL
.| ...||. || .|.  | |.|..||.| ....   .|.. .|| |||.|.|...|..|..|.. .... .|||||...||||.....|..|||    .
iialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

NDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNH-KRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLD
.|||....| ..|||||||.| | .|.||  ||| . .. |..||..|. .. |    |. ||... . |   .  ...||. | ||| |||...  ||.
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FRDIVKNANPADSG-PIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPT
. . |...   | | |..|||||||||||.||... ..| ...|. .|||. ....|..|  ||| ..|| |... | .  .| . |  . .|  
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlra
subfamily_PTPRG_pd Subfamily PTPRG 1946-2223 1.6e-87 289.1 In-house 1-288 (563) alignment 
Range on Protein: 1946-2223
Range on HMM: 1-288/563.0
IHISNLAKVI-KAKRMSRDGFEKEYKALLNKSDEG----CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGA-DYINATFIDGYKKENAFIASQGPN
......|| . . .  .  ||..|..|| ... .        ..|||| |||| ||..||. ||||..|| . .  ||||| .||||.|..||||.||| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSaGNHKRYGELEVIAREVKDEGSYVLRKFEVGK-----PDRTTNRLNITQYHYTIWPDMGVP
.  ..|||.|..||....|||.||| |. ..||  |||.  . ..||.|.|   | .   .|  |.. . .      ... . ....||||| |||.|||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

ESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
|.| | | |    . ||.|. |||.||||||||||||.| .. ... |..|....||.|.  .| .| |.|| . || |....||..  
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Ptp69D_pd Subfamily Ptp69D 1945-2234 4.1e-87 287.2 In-house 3-298 (307) alignment 
Range on Protein: 1945-2234
Range on HMM: 3-298/307.0
PIHISNLAKVIKAKRMSR-DGFEKEYKALL--NKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAA
.|.| .|.. .|...     |..|||. |   . . .  .... ||. ||||..|...|..||||.|.. .  .||||| || |||... |||.|.|  |
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

SLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAgNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRT----TNRLNITQYHYTIWPDMGVPESS
 ..|||.|. ||   .||||.|| ||..|||  |||   . ..||.. |   . .  . |. |...| | . .     .. ...||||| |.|. |||..
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

QPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDL
. ||.. . |.. .  . .||.|||||||||.|.|.... ... ..||.|.|.|... ..|..| ..||  .||.|.|  ||..|.  .   .. ||
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl
0036941 (Phosphotyrosine protein) phosphatases II 1957-2227 4.7e-87 287.3 In-house 7-282 (297) alignment 
Range on Protein: 1957-2227
Range on HMM: 7-282/297.0
AKRMSRDGFEKEYKALLNKSDEGC--IGNNPENKPKNRYKNIITYDEHRVKLnklpTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQR
 | ... ...||.. ||.    |   ....|||..|||||.|. ||  ||||    ...| ||||| ..|||. ...||| |||   ...|||.||.||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

TSTIVMLTNLLEKDKKKCIEYWPSA-GNHKRYGELEVIAREVKD--EGSYVLRKFEVGKPdRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNAN
...|||||.| |....|| .|||.  |. . ||.. |  ..|.   ...|.||..|| .  .. . . .|..||| |||.||||| ..|||| . |....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvl

PA--DSGPIIVHCSAGVGRTGTFITINCMIEMIE---AEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKV
..  ..||..|||||||||.||||.. .|....|    |...|........|..|...||  .||.|.||.||..  . ..
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1943-2229 6.8e-86 283.0 In-house 3-286 (315) alignment 
Range on Protein: 1943-2229
Range on HMM: 3-286/315.0
HEPIHISNLAKVIKAK-RMSRDGFEKEYKALLNKS-DEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNA
|.|| . .|   .  |   ...||...|...         . .. ||| |||| |||.||. ||.|  | ..|..||.||.|||||.|.. .||.||||.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAgnHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTnrlNITQYHYTIWPDMGVPESSQPL
||..|||..|.|.  ..||||||| |..|.|. .|||    .  ||.. |  .. . .  |  | . |   |.     .. |.||| |||||||... ||
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnir...evvqlhytswpdmgvpkytipl

LDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSF
...   ||  . .. |.|.|||||||||||||||...... .|||. |||.|||. .|. |  |||| .||.|||..||.   |   | 
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi
0047943 (Phosphotyrosine protein) phosphatases II 1958-2220 2.3e-85 281.7 In-house 7-270 (273) alignment 
Range on Protein: 1958-2220
Range on HMM: 7-270/273.0
KRMSRDGFEKEYKALLNKSDEG--CIGNNPENKPKNRYKNIITYDEHRVKLnklpTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRT
|. .......|...||.  ...   ... |||| |||||.|. ||  ||||    ...| ||||| ..|||.....||| |||   ...|||.||.||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

STIVMLTNLLEKDKKKCIEYWPSAGN--HKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTnRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPA
..|||||.| |....||  |||. |.  ...||.. |  .... ...|..|..|. . .     . .|..||| |||.|||.| ..||.| ..|..|. |
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalea

--DSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQ
  ..||..||||||||||||||.. ......|.|...||.. .. .|..|  |||  .||.|.||.|| 
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
DSPc_SM00195 1966-2221 6.5e-85 280.0 In-house 3-261 (263) alignment 
Range on Protein: 1966-2221
Range on HMM: 3-261/263.0
EKEYKALLNKS--DEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTN
..|.. |...   .|   .. ..|| |||||||. ||. ||||.| ....| ||||| .|.|..|....|| |||    ..|||.||.|.....|||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LLEKDKKKCIEYWPSA-GNHKRYGELEVIAREVKDEG-SYVLRKFEVGKPDRtTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVH
  |..|.|| .|||.  |. ...|...|  .||. .  ...||..|. | ..  .  ..|||.|. ||| |||.| ...|..   ||. .   ||||.||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
|||||||||||.||..... .|.|||.|.|. ..|.|| |. ||| ..|| ||||..|..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1966-2221 6.5e-85 280.0 In-house 3-261 (263) alignment 
Range on Protein: 1966-2221
Range on HMM: 3-261/263.0
EKEYKALLNKS--DEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTN
..|.. |...   .|   .. ..|| |||||||. ||. ||||.| ....| ||||| .|.|..|....|| |||    ..|||.||.|.....|||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LLEKDKKKCIEYWPSA-GNHKRYGELEVIAREVKDEG-SYVLRKFEVGKPDRtTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVH
  |..|.|| .|||.  |. ...|...|  .||. .  ...||..|. | ..  .  ..|||.|. ||| |||.| ...|..   ||. .   ||||.||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
|||||||||||.||..... .|.|||.|.|. ..|.|| |. ||| ..|| ||||..|..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0039614 (Phosphotyrosine protein) phosphatases II 1956-2221 1.8e-84 279.0 In-house 25-288 (297) alignment 
Range on Protein: 1956-2221
Range on HMM: 25-288/297.0
KAKRMSRDGFEKEYKALLNKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTE-PGADYINATFIDGYKK-ENAFIASQGPNAASLNDFWQMVYEQ
. |..|. ....|.. ||.  ..  |.. ||||.|||||.|. || .||||. ..   .. ||||| ..|||..  ..|||.|||.  ...|||.||.||
lekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

RTSTIVMLTNLLEKDKkKCIEYWPSAGNhkRYGELEVIAREVKDEGSYVLRKFEVGKPDRTtnrLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPA
....|||||.| |... || .|||. |.  .||.. |  ..|. .. |..|..|| . . .   . .|...|| |||.|||.|.. ||.| ..|..|. .
gvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhgvppslellleflelvrealae

--DSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
  ..||..||||||||||||||..  |.|..| |...||.. ..|.|..|  .||  .||.|.|. ||..
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1954-2220 8.9e-84 275.9 In-house 5-274 (281) alignment 
Range on Protein: 1954-2220
Range on HMM: 5-274/281.0
VIKAKRM-SRDGFEKEYKALLN--KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMV
 .|...  .  || .||..| .   ..     ...||. ||||.||. ||  |||...  ..  .||||| |..|||.|...||.|||  |||..|||||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

YEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIAREVKDEGSYVLRKFEVgkPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKN-
.||. |.|||.|. .|..| ||  |||   .. .||.. |   . ... .|. |||..    ....  ...| .|| ||| |||.... ||.||. |.. 
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkl

ANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAE-KKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQ
 ..    |...|||||||||||.|... ... .||| ...|| . ..|.||.| .|||   ||||.| ..|.
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
0045450 (Phosphotyrosine protein) phosphatases II 1961-2221 1.1e-83 276.8 In-house 25-303 (307) alignment 
Range on Protein: 1961-2221
Range on HMM: 25-303/307.0
SRDGFEKEYKALLNKSD----EGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTE-PGADYINATFI--------DGYKKENAFIASQGPNAASLNDFW
.. |..||.. ||.  .    |  |.. ||||.|||||.|. || .||||. |. . .. |||||...        |||.. ..||| |||   ...|||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

QMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIV
.|..||....|||||.| |....|| .|||. | .. ||.. |  .... ...|..|..||   | | . . .|..||| |||.|||.| ..|||| ..|
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KNANPA--DSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKK---IDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
..|. .  ..||..||||||||||||||..  |....|.|..   .|... ....|..|  .|| ..||.|.|| ||..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 1959-2221 1.7e-83 275.6 In-house 16-276 (278) alignment 
Range on Protein: 1959-2221
Range on HMM: 16-276/278.0
RMSRDGFEKEYKALLNKS-DEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTST
. .. ....|.. ||.   |.  |.. ||||.|||||.|. || .||||. |. ... ||||| ..|||.. ..|||.|||.  ...|||.||.|....|
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLTNLLEKDKKKCIEYWPsaGNHKRYGELEVIAREVKDEGSYVLRKFEVGKpDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGP
|||||.| |....|| .|||  |....||.. |  .... .. |..|..|| .  .. . . .|.|||. |||.||||| ..||||  .|..|.. ..||
ivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

IIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
..||||||||||||||..  ..|..| |...|... ..|.|..|. .|| ..||.|.|| ||..
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRK_pd Subfamily PTPRK 1951-2237 3.6e-83 274.0 In-house 9-292 (314) alignment 
Range on Protein: 1951-2237
Range on HMM: 9-292/314.0
L-AKVIKAKRMSRDGFEKEYKALLNKSDegcIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQM
|  .. . ||    || .||..|..  |     .. ||. |||...|..|| .||.|  .  .| .|||||..||.||. .|||. |||    ..|||..
llqsiallkraegygfkeeyeslfegwd...aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

VYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHkrYGELEVIAREVKDEGSYVLRKFEVGKPDRTTN-RLNITQYHYTIWPDMGVPESSQPLLDFRDIVK
||......|||||.| |. . ||..|||  ...  ||...|   |.. .  .| | | | |  |. . .  . |.... ||| .|| | . ||..   ||
vydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvk

NANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTT
. .. . |.|.|||||| |||||||.|. ...||| |. .|||| . ..|.|.  ||....|| |||. .|.   | . .  . .. ..
ksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkal
Y_phosphatase Protein-tyrosine phosphatase 1987-2219 9.8e-82 269.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 1987-2219
Range on HMM: 1-234/235.0
NKPKNRYKNIITYDEHRVKLnklPTEPG-ADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWP-SAGNHKR
|| |||||.|. ||. ||||     ..|  ||||| ...|||....|||.|||   ...|||.||.......|||||.| ||...|| .||| . .. ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGELEVIAR-EVK-DEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMI
||...|  . ..| || .|.|||.|. | .. ...  ..|.||| ||| |||||...|||. . |.. . |.|||..|||||||||||||.......|..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
|||...||.....|.||.|. |||  .||.|.|...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1987-2219 9.8e-82 269.2 In-house 1-234 (235) alignment 
Range on Protein: 1987-2219
Range on HMM: 1-234/235.0
NKPKNRYKNIITYDEHRVKLnklPTEPG-ADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWP-SAGNHKR
|| |||||.|. ||. ||||     ..|  ||||| ...|||....|||.|||   ...|||.||.......|||||.| ||...|| .||| . .. ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGELEVIAR-EVK-DEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMI
||...|  . ..| || .|.|||.|. | .. ...  ..|.||| ||| |||||...|||. . |.. . |.|||..|||||||||||||.......|..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
|||...||.....|.||.|. |||  .||.|.|...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1981-2224 2.3e-81 267.7 In-house 3-244 (250) alignment 
Range on Protein: 1981-2224
Range on HMM: 3-244/250.0
IGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKkCIEYWPSAG
....|.|| |||| .||..|. || |.|  ..  .|||||.|..||....||||.|||  |...|||.||.|. ..|||||||| |..|. . .|||  .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

nHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRlNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPA-DSGPIIVHCSAGVGRTGTFITINCMI
  ..||.. |   . .  . |. ||. . |  .. .|  . |.|.. ||| ||||  .  |.... |.  ..  ...|.||.|||||||.|.||.|....
.aekyGdvtvsllskeefadytkrklklskakkader.ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHC
| .. ||..|||..|. .|| |  .|. ..|| |.|| .|.   .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1963-2243 1.4e-79 262.7 In-house 34-312 (319) alignment 
Range on Protein: 1963-2243
Range on HMM: 34-312/319.0
DGFEKEYKALLNKSDEGC---IGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIV
  .| |.... ... ...     | ..|| |||. ||...|. .|||..|  | ..|||||.|..||.... .||.|||   .|.|||.|..|...||||
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLTnllekdKKKCIEYWPSAGNHKrYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNA--NPADSGP
.||      |.|| .|||  .. | ... .|    |..   ||.|..|. .  . ..  .|||.|.  |||.|||... .|. . . |.       .  .
llt......kdkcsqywplkivik.eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

IIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTWGT
|.|||||||||||..|.......... ||..||.||....|..|  .||   || ||| .||.     .   .. |.|. ..   .
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
subfamily_PTPN6_pd Subfamily PTPN6 1948-2223 1.5e-79 262.2 In-house 13-298 (306) alignment 
Range on Protein: 1948-2223
Range on HMM: 13-298/306.0
ISNLAKviKAKRMSRDGFEKEYKALLNK----SDEGCIGNNPENKPKNRYKNIITYDEHRVKLNkLPTEPGADYINATFIDG--YKKENAFIASQGPNAA
.|.| |  . ..... |||.|...| ..      .   |. |||| |||||||. .|. ||.|.  |  ||.||||| .|..   ......||.||   .
vselek..eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclet

SLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLL
 ..|||.||... .  |||.|. .|. |.||. |||.. ....||...|   . |.  .|.||.. | | .. ..  .. |||.. ||| |||.. . .|
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

DFRDIVKNAN----PADSGPIIVHCSAGVGRTGTFITINCMIEMIEAE---KKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
|| . |.. .     |..|||.||||||.||||||| |......|| .    .||. .... .|. |  .||..||| |.|... .. .
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0042113 (Phosphotyrosine protein) phosphatases II 1983-2220 2.7e-79 261.3 In-house 5-241 (245) alignment 
Range on Protein: 1983-2220
Range on HMM: 5-241/245.0
NNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSaGNH
. ||||.||||..|. ||  ||||.  ..... ||||| ..|||.  . |||.||| . ...|||.|..|.. .||||||.. |....|| .|||. |..
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges

KRYGELEVIAREVKDEGSYVLRKFEVGKpDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANP-ADSGPIIVHCSAGVGRTGTFITINCMIEM
..||.. |  .... ...|..|..|| . ...   .....|||. |||.|||.... |||| ..|..|    ..||..||||||||||||||..  |.|.
ltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQ
.|.|....... . |.|..|  .|| ..||.|.|| ||.
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1963-2259 8.9e-79 259.6 In-house 19-314 (315) alignment 
Range on Protein: 1963-2259
Range on HMM: 19-314/315.0
DGFEKEYKALLNK-SDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVML
  | .|.. | .    .  .. ...| .|||||||. .|. ||||. .  .|  |||||..| ......|.||||||. ||..|||.||......||||.
alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TNLLEKDKKKCIEYWPS-AGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDrttNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIV
|.. | || ||  |||   ..  ..|...|   ...  .  | ||. . | .   .  ..||...| ||| ||.. .  || .   ||  |  .  ...|
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse...esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllv

HCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTWGTIKDADGRTEMSRQFEV
|||||||||| .|.|. ... |. .. .|||||....|. | ..|| ...| |||...|.  .  ..   .| .   ..   |  |. ||..|...|| 
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefet
subfamily_PTPN9_pd Subfamily PTPN9 1948-2223 2.1e-78 258.4 In-house 3-291 (297) alignment 
Range on Protein: 1948-2223
Range on HMM: 3-291/297.0
ISNLAKVIKAkrMSRDGFEKEYKALLNKSDEGCIG--NNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLND
|..| . .|.  . . |  |||... |.. || .   . . |  ||||.... ||| ||.|.|.. .. .||||| |.||||...|||| |||     .|
ieelvayvke..kgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWP-SAGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRlNITQYHYTIWPDMGVPESSQPLLDFR
||.||.||.. .||| | ..|. . || .||| . .. ...|.|.|   ||. |  |. |..|. . .   .| ..| . .. ||| |||.|.. |||..
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaaslldvl

DIVKNAN-------------PADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
. |...              ...  ||.||||||.||||||||..  .. .| . ..||.. .. .|..|||..|...|||| | ..|... 
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1986-2269 3.7e-78 257.9 In-house 42-323 (515) alignment 
Range on Protein: 1986-2269
Range on HMM: 42-323/515.0
ENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPS-AGNHKR
 | .|||||||. ||  ||||. .  .|  ||.||..| ... ..|.||||||| ||..|||..|......||.|.|.| | || || .|||   |.  .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YGELEVIAREVKDEGSYVLRKFEVGKPDRttnRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEA
.|...|    ..  .  . ||..| | |       .||.|.| ||| |||. .. || .   ||  .   . |.|.|||||||||| .|.|. ..  .. 
fGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakt

EKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTWGTIKDADGRTEMSRQFEVLEYMAPMEST
 . .|||||.. .|..| ..|| |.|| |||...|.  .  .    .| .   ..   .  |  ||. | ..|. |. ..|   .
trmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1980-2241 3.9e-78 257.8 In-house 18-274 (284) alignment 
Range on Protein: 1980-2241
Range on HMM: 18-274/284.0
CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTnllekdKKKCIEYWPSA
   | ..|| |||. .|...|. .|||..|  | ..|||||.|| ||.... .||.|||   .|.|||.|..|...||||.||      |.|| .|||  
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

GNHKrYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNA--NPADSGPIIVHCSAGVGRTGTFITINC
.. | ... .|    |..   ||.|..|. .  . ..  .|.|.|.  |||.|||... .|. . . |.       .  .|.|||||||||||..|....
ivik.eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

MIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTW
...... ||..||.||....|..|  .||   || ||| .||.     .   .. |.|. ..  
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0045098 (Phosphotyrosine protein) phosphatases II 1976-2222 8.7e-78 256.8 In-house 22-272 (278) alignment 
Range on Protein: 1976-2222
Range on HMM: 22-272/278.0
SDEGCIGNNPENKPKNRYKNIITYDEHRVKlnklptepgaDYINATFIDGYkkENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEY
 .|   .. ..|..|||||.|. ||  |||          |||||..||||   ..||| |||    ..|||.|..|.....|||||.|.|....|| .|
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPSaGNHKRYGELEVIAREVKDEGSYVLRKFEVGKP---DRTTNRLNITQYHYTIWPDMGVPESS--QPLLDFRDIVKNANPA-------------DSGP
||. |....||...|   ...  . |.||...|      . .   ...|..||. |||.|||...  ...|.. . ...|. .             ..||
wpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

IIVHCSAGVGRTGTFITINCMIEMIeaEKKIDVFNFINEMRKRRAF-MVQVQQQYEFIYETLLQWS
..||||||||||||.. . .|.|..  |...|... ..|.|..| . .|| ..||.|.|| ||.. 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0040439 (Phosphotyrosine protein) phosphatases II 1982-2221 1.2e-77 256.1 In-house 6-245 (249) alignment 
Range on Protein: 1982-2221
Range on HMM: 6-245/249.0
GNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSaGN
.. ||||.||||..|. || .||||. ||  .. ||||| .||||.  ..||| |||   ...|||.|..|.. ..|||||.| |....|| .|||. |.
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.gg

HKRYGELEVIAREVKDEGSYVLRKFEVGKPdRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPA--DSGPIIVHCSAGVGRTGTFITINCMI
.. ||.. |  ..|. ...|..|..|. .   . . . .....|| |||.|||.| ..|||| ..|..|. .  ..||..||||||||||||||..  |.
sleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

EMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
|..| |...|... ....|..|  .|| ..||.|.|| ||..
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 1980-2221 1.2e-76 252.3 In-house 33-276 (290) alignment 
Range on Protein: 1980-2221
Range on HMM: 33-276/290.0
CIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSA
  |...||. |||||.|. ||. ||.|.|   |.| ||||| || | ... ..||.||| .. |.|||.|..|.... .||. ...| .||||  |||. 
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

GNHKR-YGELEVIAREVKDEG-SYVLRKFEVGKPdrtTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINC
|...  .||.||   | |     ...| ..| .     .. ...|.||| ||| |||.| ..||.. . |.. . ... |..|||||||||||| |.|. 
geeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

MIEMIEAEKK---IDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
. |...|||    .|||. . |.||.|| .|| ..|||..|..... 
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1949-2221 1.7e-73 242.5 In-house 8-287 (325) alignment 
Range on Protein: 1949-2221
Range on HMM: 8-287/325.0
SNLA-KVIKAKRMSRDGFEKEYKALLNKSDE-GCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDF
 ||  .| | |   .||| .|.. | ..      .   |||| |||.||....|. || |. .  .| .|||||...  .|| . |.|.| |..|..||.
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WQMVYEQRtSTIVMLTNLLEKDKKKCIEYWPSA-GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTtNRLNITQYHYTIWPDMGVPESSQPLLDFRD
|..|.. | ...|...| |...|..|  |||   |. |..| |||  | ...   || |...| ....  . . . |...  |.||||..    |. . .
WrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilq

IVKN------ANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
.||.      ||   |.||.|||||||||||.||.. .... .  | ..|.|.|.. .|| |  ||.   || .|||.| . 
lvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
0037934 (Phosphotyrosine protein) phosphatases II 1983-2221 2.4e-72 238.7 In-house 6-241 (243) alignment 
Range on Protein: 1983-2221
Range on HMM: 6-241/243.0
NNPENKPKNRYKNIITYDEHRVKLnklptePGADYINATFIDGYKKenaFIASQGPNAASLND----FWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPs
. |||..||||..|..||  ||||      .| ||||| .|.....   .||.|||   ...|    ||.|..|.....|||||.| |....|| .||| 
llpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

aGNHkRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNA--------NPADSGPIIVHCSAGVGRTG
 |.. .||...|   ...  ..|..|....  .| .   .....|||. |||.|||.| ..|||| |.|..         .  ..||..|||||||||||
.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFITINCMIEMIeaekKIDVFNFINEMRKRRAF-MVQVQQQYEFIYETLLQW
|.|..  |....    ..|... ....|..| . .|| ..||.|.|| ||..
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1956-2226 7.7e-72 236.7 In-house 13-282 (287) alignment 
Range on Protein: 1956-2226
Range on HMM: 13-282/287.0
KAKRMSRDGFEKEYKALLN---KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNklptEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYE
| .. ...||.. .. | .   . ||  ..  ..||.|||...|. .|..|| |.    .   |||||.||||||...|||....| .  . .||... .
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWklidd

QRTSTIVMLTNLLEKDKKKCIEYWPSAGNhKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMG-VPESSQPLLDFRDIVKNAN
.. ..||||... |.|...| .|||.  .   .|| ..   . . . .|. ||.|| . ..........||..| |.. | |.|    || . . .|.  
rnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr

PADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEK
    ..|.||||..|||...|. ..  |.  . |  ||||. ....| ..  .||  .||.||.. .|.  .. .
krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1939-2226 8.2e-72 236.8 In-house 3-288 (297) alignment 
Range on Protein: 1939-2226
Range on HMM: 3-288/297.0
RPPQHEPIHISNLAKVIKaKRMSRDGFEKEYKALLNK-SDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKenAFIASQG
 | . .|| .|..| ... | .. | |..|.. |..    ..   ..  | .|.|||||. ||  ||||. . ..| .||.|| |. |.|.   .|..| 
spkerrpiplsdfatlvq.knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqm

PNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKkKCIEYWPSAGNHKrYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLnITQYHYTIWPDMGVPE--
|. |...|||.||.....||||||... |.|| ||  ||.  |  . .|.. |.   |..   .. |..|| | .  ..|. . ||... |||  |..  
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrv.vkqyqfveWPdkaverkd

SSQPLLDFRDIVKNANP-ADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEK
| . ||.. . |..      .||..|||.||||||| ..||. ..  .. ||..|.|.... .|. | ..|| ..||.|.|...|.   .|.
sassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_PTPN3_pd Subfamily PTPN3 1981-2222 3.9e-71 234.2 In-house 35-275 (280) alignment 
Range on Protein: 1981-2222
Range on HMM: 35-275/280.0
IGNNPENKPKNRYKNIITYDEHRVKLNKLPTepgaDYINATFI----DGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYW
. . ||| .||||..|..||. ||||.. .|    ||||| ..    .. .  | .||.||| | . .||||||.||..|.|||||.|.|. ..|| .||
aarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PSAGNHKRYGELEVIAREVKDEGSYVLRKFEVGKpDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITIN
|. ... .|||..|  .. . . |||||.. . .  .|... .|.|  |. ||| |||..|. .|.| . |...  ... |..||||||.|||| .|...
Petedeleygefsvkcekedetksyvlrelvlkd.ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

CMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWS
  . .|||.... . . . .|| .|| .|| ..||.|. |..|. .
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1954-2221 6.1e-71 233.6 In-house 11-282 (290) alignment 
Range on Protein: 1954-2221
Range on HMM: 11-282/290.0
VIKAKRMSRDGFEKEYKALLNK--SDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPG--ADYINATFIDGYKKENAFIASQGPNAASLNDFWQM
|.. .   ..||....|.| .   . .  .|. ..||..||..||. ||..|. |.... ..    .||||..|.|||.....|| |||    | |||..
vanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

VYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKrYGELEVIA-REVKDEgSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMG-VPESSQPLLDFRDIV
....... ||||||  |..|.||  |||...... ||| ..    | . . .|. ||.|| . . . .. ..|||. | |.. | |.. .  || .. ..
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy

KNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
|.      ..|.||||..|||...|....  |.  . |  ||||. ....|  .  .|| .|||..|.. .|. 
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1986-2223 3.4e-68 224.7 In-house 27-269 (274) alignment 
Range on Protein: 1986-2223
Range on HMM: 27-269/274.0
ENKPKNRYKNIITYDEHRVKL-NKLPTEPGADYINATFIDGYK-KENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNH-
 .. |||||.|.  .. || | .. .... ..|||| .| ||. ...|..| ||| .  ..|||.|.|..... |||||.| |....|| .|.| | .  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--KRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNrlnITQYHYTIWPDMGVPESSQPLLDFRDIVKNANP---ADSGPIIVHCSAGVGRTGTFITINC
  .|||..|.  ......  | .||. . .  |. .   .. | || |||. .|.. ..|||. . |....    |  .|..||||||.|||| ||.|. 
iserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

MIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
 .  ...|...||.. . ..|  |  ||| ..|||.|...| .. .
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0050432 (Phosphotyrosine protein) phosphatases II 2241-2518 1.1e-66 220.7 In-house 32-306 (308) alignment 
Range on Protein: 2241-2518
Range on HMM: 32-306/308.0
WGTIKDADGRTEMSRQFEVLEYMAPmesTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLmtkgdEvDDNDYINASFFDVE--GRKNVHVCTQCPLMSTVG
.  ...|.... ....|| |  . |    ..   ..|| | .||||.| .| |.    |     . ...||||||. |.   ....  ..|| || .||.
lkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....d.egsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRLVWDYDIHTIIHLNEMDST----CGQYWPDS---DKTNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFF
||||.||......|. |.. .      | ||||..   . ...| ||..|||  .  |..| |.|..| .... .|..|...|..|| |  || |  ...
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeill

ELLTQVDNNNtSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYA
..| .|.. . .... .| |..||| . ||.|.  ..........||.|.|||.||. |||.|  .| |.|.|..|. |  ...|..
dflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
0051299 (Phosphotyrosine protein) phosphatases II 2245-2510 8.2e-65 214.4 In-house 18-285 (288) alignment 
Range on Protein: 2245-2510
Range on HMM: 18-285/288.0
KdADGRTEMSRQFEVLEYMAPMestGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLV
. |.| | . ..|| |  . |.   ..   ..|| | .||||.| .| |. .  | . .. |...||||||. |.  .|.  ..|| || .||.||||.|
l.angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

WDYDIHTIIHLNEMD----STCGQYWPDSDKTNFGSFTIELLSDRTlTDTMTERVLKVTTS----KKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQ
|......|. |.. .     .| ||||.......| .|..|||  .  |..| |.|.||      ... .|..|...|..|| |  || |  .....| .
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrl

VDNNNTS-EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
|.. . | ..  .| |..||| . ||.|.  ....... ..||...||||||. |||.|  .| |.|.|..|. |
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1945-2259 1e-64 213.4 In-house 3-273 (392) alignment 
Range on Protein: 1945-2259
Range on HMM: 3-273/392.0
PIHISNLAKVIKAKRMSRdGFEKEYKALLN-KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASL
|| ....  ... .| |   | .|.. | . .  .  ..... |..|||||||. ||. ||||. .   |  ||.||..|.... |.|.|||||||||||
pipvaqfpafveknrhsa.lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

NDFWQMVYEQRTSTIVMLTNLLEKDkkkcieywpsagnhkrygeleviarevkdegsyvlrkfevgkpdRTTNRLNITQYHYTIWPDMGVPESSQPLLDF
.|||.||......||.|.|.| | |                                            .  .   ..|.|.| ||| .||. .  || |
ddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkf

RDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTVKTWGT
   ||      . |.|.||||||||||  |.|....   .  . .|||||. ..|..| .|||...|| ||| ..|.     ..   .. .   ...  |
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

IKDADGRTEMSRQFEV
  | |.|. ....|. 
ssdGdvrskqlkefrs
0046845 (Phosphotyrosine protein) phosphatases II 2253-2518 1.5e-64 213.4 In-house 2-281 (284) alignment 
Range on Protein: 2253-2518
Range on HMM: 2-281/284.0
MSRQFEVLEYMAPMEStGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNDYINASFFDVE-----GRKNVHVCTQCPLMSTVGDFWRLVWDY
. ..|| |  . .. .  |   . || | .||||.| .| |. .  | . .....|.||||||. |.       .|.  ..|| || .||.||||.||..
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

DIHTIIHLNEMDS----TCGQYWPDSD-KTNFGSFTIELLSDRTlTDTMTERVLKVTTSK-KKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNN
....|. |.| ..     | ||||... . ..| ||..|||  .  |..| |.|..|  . .. .|..|...|..|| |  || |  |..|.| .|.. .
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrell

TS---EKKFLVVCMDGVGASPTFLAANAAIDRVREDK---TVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYA
..   ... .| |..||| . ||.|.  .........   .||...||||||. ||| |  || |.|.|..|. |  .. |..
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1986-2219 3.9e-64 211.1 In-house 2-236 (237) alignment 
Range on Protein: 1986-2219
Range on HMM: 2-236/237.0
ENKPKNRYKNIITYDEHRVKLNKLPTEpgADYINATFIDGYKK-ENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKR
||| |||| ||..||  || |.   ..  .||||||...|.    . .||.|||  .| .||||||.... | ||||| |.|....|| .||||. . . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPA--DSGPIIVHCSAGVGRTGTFITINCMIEMI
|| | |  .  ..   | .| . . |  .  .   | ||..| ||| |||. .  || ||  . | .|   .||| |.|||||||||| |. |..|.   
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

EAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
. .| .|..|..  . . | ...|...|| ||..|.|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPN13_pd Subfamily PTPN13 1959-2220 4e-64 211.5 In-house 7-267 (273) alignment 
Range on Protein: 1959-2220
Range on HMM: 7-267/273.0
RMSRDGFEKEYKALLN--KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTepgadYINATFIDGYKKE--NAFIASQGPNAASLNDFWQMVYEQR
.. ..  ..|.| | .    |.  .|.. ||| ||||.|.. ||| ||||..  .     ||||..|     .    .||.|||   . .||||||.||.
kldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

TSTIVMLTNLLEKDKKKCIEYWPSAGNHK--RYGELEVIAREVKDEGSYVLRKFEVGKpDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANP
.. |.|.|.  ||.| ||  |||.  |.|   .. |||   .|..  ..|.|...| .  ....  .... ... ||| ||| |...|| |   |.. . 
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd.sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

aDSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQ
 |.|||.||||||.||.||.|||. ....|| .|..|| . ....|..|  .|| ..|| |.|...|.
.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2239-2518 1.1e-63 210.2 In-house 15-297 (298) alignment 
Range on Protein: 2239-2518
Range on HMM: 15-297/298.0
KTWGTIKDADGRTEMSRQFEVLEYMAPMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVG
.   ..| . . | .. .|. |. .     . . . .. | | |||||.| ...|. . .| .. |. .. ||||||| .   ..| .. || ||..|| 
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeke.dadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDSDKTNFGSFTIELLSDRTLTDTmTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELL
||||.|...|| ||. |...      .. .||||. |...|..|..|||. . .|  . | |||. .|...||.. ||..  || |  ||. .   ..||
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadl.ivrklkvskkkeekerevrqlhftsWp.dkgvpenatsvldll

TQVDNNNTSEK--KFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYA
..|  ...  .    .| | .||| | || | .. ..||.....||.| .||.|||.|||.|.  |.| |.|..   . || ....
rkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0047943 (Phosphotyrosine protein) phosphatases II 2244-2510 3.1e-63 209.2 In-house 5-271 (273) alignment 
Range on Protein: 2244-2510
Range on HMM: 5-271/273.0
IKDADGRTEMSRQFEVLEYMAPmesTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLmtkgdEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRL
.....|.| . ..|| |  . |    .. . ..|| | .||||.| .|.|.    |     . ...||||||. |.  .|.  ..|| || .||.||||.
lekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VWDYDIHTIIHLNEMDST----CGQYWPDSD---KTNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQ
||......|. |.| ..     | ||||..    ....| ||..|||  |  |..| |.|..| .. . .|..|...|.||| |  || |  ...|.. .
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefiel

VDNNNT---SEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
|.. .    |... .| |..||| . ||.|.  ..|.... ..||...|||.||. |||.|  .| |.|.|..|. |
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1979-2224 1.9e-62 205.7 In-house 12-266 (270) alignment 
Range on Protein: 1979-2224
Range on HMM: 12-266/270.0
GCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKE-NAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWP
  . .   .|  |||..|.   . ||.|..| ... . |||| .. |...| ...||..|| ...|..||.|..|.....|||.|.| || .|||  |||
sdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

SAGNH---KRYGELEVIAREVKDEGSYVLRKFEVGkpdRTTNRLNITQYHYTIWPDMGVPESSQ------PLLD-FRDIVKNANPADS-GPIIVHCSAGV
.  ..    ..|...|.| . . |  |.|.. ..    .. .. ... ..|. ||| |||....       ||  .|.. .  .  |  .|..|||||||
aepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHC
|||||.|... .....| .||.|| . |.|.|| |  .||  .||||.|...... . 
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
DSPc_SM00195 2255-2510 5.9e-62 204.7 In-house 4-261 (263) alignment 
Range on Protein: 2255-2510
Range on HMM: 4-261/263.0
RQFEVLEYMAPMEstgSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEvDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIH
..|| || ... .   . ...  . | .|||| . .|.|. .  | .. .. ...|||||.. ... .|.  ..|| || ||| ||||.||. ....|. 
eefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LNEMDS----TCGQYWPDS--DKTNFGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDsLVPRSKMDFFELLTQVDNN-NTSEKKF
|.| .     .| .|||..  .|..||.....| .  .  | .. |.|..|  .|. .|..||.|| .||.   || |.....||| .|..  .||..  
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpi

LVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.|.| .||| . ||.... ......|.|.||||. ||.|||.|||.|..|| | |.|.....|
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 2255-2510 5.9e-62 204.7 In-house 4-261 (263) alignment 
Range on Protein: 2255-2510
Range on HMM: 4-261/263.0
RQFEVLEYMAPMEstgSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEvDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIH
..|| || ... .   . ...  . | .|||| . .|.|. .  | .. .. ...|||||.. ... .|.  ..|| || ||| ||||.||. ....|. 
eefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LNEMDS----TCGQYWPDS--DKTNFGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDsLVPRSKMDFFELLTQVDNN-NTSEKKF
|.| .     .| .|||..  .|..||.....| .  .  | .. |.|..|  .|. .|..||.|| .||.   || |.....||| .|..  .||..  
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpi

LVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.|.| .||| . ||.... ......|.|.||||. ||.|||.|||.|..|| | |.|.....|
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1985-2231 6e-62 204.5 In-house 46-288 (439) alignment 
Range on Protein: 1985-2231
Range on HMM: 46-288/439.0
PENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKkkcieYWPSAGNhKR
  ...|||||.. ..|  || |...|  | . |||| .|.|| ... .||.|||.  . .|||..|.|..|.||||||||.|  |     |||| ..   
eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vc

YGELEVIAREVKDEGSYVLRKFEV-GKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDF-RDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMI
||.. | .    .   ||.| | |  . |.| .   . |.||. |||  ||  .  .||| | |    .  . ||..|||||||||||| |...  .| .
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql

EAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSI
 .|.|.|.   .. .||.|  |||   || |||...|.     ... .|
klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavti
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1987-2219 1.1e-61 203.1 In-house 7-237 (239) alignment 
Range on Protein: 1987-2219
Range on HMM: 7-237/239.0
NKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKK-ENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGnhKRY
|| |||| ||.|||  || |.||  .| .|||||...  |    .|.||.||  ..|  |||.|....|   ||||| |.|  |||| .||| .    .|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sky

GELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLnITQYHYTIWPDMGVPESSQPLLDFR-DIVKNANPAdSGPIIVHCSAGVGRTGTFITINCMIEMIEA
 .| |  |. .    |..| | . .  .| .|  . |||.|.||| |||. .  .| .|  | |.. |  . | ..||||||||||.|. |..|.   . 
cnlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtgaflvidamlrqakk

EKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
.| .|.||... .|. | .|||  .|| ||. ..|
qktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1987-2219 1.2e-61 202.9 In-house 8-238 (239) alignment 
Range on Protein: 1987-2219
Range on HMM: 8-238/239.0
NKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKK-ENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGnhKRY
|| |||| ||.|||  || |.||  .| .|||||...  |    .|.||.||  ..|  |||.|....|   ||||| |.|  |||| .||| .    .|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sky

GELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLnITQYHYTIWPDMGVPESSQPLLDFR-DIVKNANPAdSGPIIVHCSAGVGRTGTFITINCMIEMIEA
 .| |  |. .    |..| | . .  .| .|  . |||.|.||| |||. .  .| .|  | |.. |  . | ..||||||||||.|. |..|.   . 
cnlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtgaflvidamlrqakk

EKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
.| .|.||... .|. | .|||  .|| ||. ..|
qktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN23_pd Subfamily PTPN23 1961-2222 2e-61 202.3 In-house 13-280 (288) alignment 
Range on Protein: 1961-2222
Range on HMM: 13-280/288.0
SRDGFEKEYKALLNKSDEG----CIGNNPENKPKNRYKNIITYDEHRVKLNklptEPGADYINATFIDGYKKE-NAFIASQGPNAASLNDFWQMVYEQRT
 . ...|..| | .| |.      |     .  |||...|. ||. ||||.    .   |||||.|. .       |||.|.| . .|||||.|||||..
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

STIVMLTNLLEKDKKKCIEYWPSA-GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRtTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNA----
|.||||..  |..|.|. .|||.. |. ...|.|.|  ..|.. . .| |....   |   .  ...  ..| ||..|||.| . ||.| | |..|    
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasPetllqfldevesayeav

NPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKI-DVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWS
.     |..|||||||||||.|  . . .. .|... . |. . .. .|. | |||| ..|..| ||  |.  
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0036941 (Phosphotyrosine protein) phosphatases II 2248-2510 8.6e-61 201.2 In-house 10-276 (297) alignment 
Range on Protein: 2248-2510
Range on HMM: 10-276/297.0
DGRTEMSRQFEVLeymAPMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLmtkgdEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDY
.... ....|| |    |.   ||   ..|| | .||||.| .| |.    |     . ...||||||. |. ..|.  ..|| || .||.||||.||..
lflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

DIHTIIHLNEMDST----CGQYWPDS--DKTNFGSFTIELLSDRT-LTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNN
....|. |.| ..     | ||||.   .  ..| ||..|||  . | |..| |.|.||  ... .|..|...|.||| |  || |  ...... .|.. 
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielvrkv

NT---SEKKFLVVCMDGVGASPTFLAANAAIDRVR---EDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.    |... || |..||| | ||.||  ......   . ..|||..||| ||. |||.|  || |.|.|..|. .
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1968-2238 5.1e-60 197.8 In-house 14-282 (283) alignment 
Range on Protein: 1968-2238
Range on HMM: 14-282/283.0
EYKALLNKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTepgaDYINATFID---GYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNL
 .| |   . .  |  . |||.|||...|...| .||.|. ..     |||||.||     ||... .|..|.|      |||.||.... ..|||||.|
vlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltkl

LEKDKKKCIEYWPSAGNHkRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSA
 |  ..||  |||. |    |||. |  |.   . |.. ... . .   . . | .. | .  | ..|       |. |  .. . .    |||.||||.
qedlrikCsqyWPkrGse.dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCst

GVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKVSFSIIDLPTTV
|.|||..||.. . .. . .|  .|||. .. ||..|  .|| ..|| ...|  |. . |       .|| .|.
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti
subfamily_PTPRN_pd Subfamily PTPRN 1961-2218 9.7e-60 196.8 In-house 27-288 (297) alignment 
Range on Protein: 1961-2218
Range on HMM: 27-288/297.0
SRDGFEKEYKALLNKSDEGC---IGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFI-DGYKKENAFIASQGPNAASLNDFWQMVYEQRTS
 .| .|||..|| .   | .   ......|  |||.|....||. ||||..  ..   |||||..| |   .. |.||.||| |... ||||||.|| . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMLTNLLEKDKKKCIEYWPSAGNHK-RYGELEVIAREVKDEgSYVLRKFEVgKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADS
 ||.||.| |.. |.| .|||  |..     |.....  .  .  |..| | . |  .|..   .||.|.  ||..||| |...||.||  |  .    |
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcd.dylvrsfyl.knlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs

GPIIVHCSAGVGRTGTFITINCMIE-MIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETL
 ||.||||.|.||||..| |. ... ..   |.||.   .. .| .|. .|. ..|.||.. ..
cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0039614 (Phosphotyrosine protein) phosphatases II 2241-2510 1.5e-59 197.3 In-house 22-288 (297) alignment 
Range on Protein: 2241-2510
Range on HMM: 22-288/297.0
WGTIKDADGRTEMSRQFEVLEYMAPmestgSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNDYINASFFDVEGR-KNVHVCTQCPLMSTVGD
.  ...|...| . ..|| |  . |     .   . ||.| .||||.| .| |     | .... . |.||||||. |.  . ..  ..|| || .||.|
llllekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWRLVWDYDIHTIIHLNEMDST---CGQYWPDSDKtNFGSFTIELLSDRTlTDTMTERVLKVTTskKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQ
|||.||......|. |.. .     | ||||..   ..| ||..||.  .  | .| |.|.||   .. .|..|..||.||| |  || |  ...|.| .
FwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslellleflel

VDNNNT---SEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
|.. .    .... || |..||| . ||.||  ....... ..||...|||.||. |||.|  .. |.|.||.|. .
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_PTPN14_pd Subfamily PTPN14 1965-2221 5.5e-59 194.6 In-house 25-295 (300) alignment 
Range on Protein: 1965-2221
Range on HMM: 25-295/300.0
FEKEYKALLNKSDEGC--IGNNPENKPKNRYKNIITYDEHRVKLNKLPTEpGADYINATFIDGY--KKENAFIASQGPNAASLNDFWQMVYEQRTSTIVM
  .||  . .|. ..    ...|||..|||.|... |.. ||.|.    .   .||||. |      ||  .|..|||    ..||||||.|| .. |||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LTNLLEKDKKKCIEYWPSA---GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDrTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKN----ANPA
||.  |. |.|...|.|.     .. ..|. .|... ..| .|.. .....     . .. ..    || ||| ||||  .. |.. . |.     .|  
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

D-----SGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
      . |..|||||||||||  |. . .|. .| ...||. . .. .|..| ..||   ||.|.|..|...
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_CG7180_pd Subfamily CG7180 1954-2225 5.7e-59 194.2 In-house 8-293 (296) alignment 
Range on Protein: 1954-2225
Range on HMM: 8-293/296.0
VIKAKRMSRDGFEKEYKALLNKSDEGCI-GNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYE
... .|  |  ...|.|   . . . |  | . ||. |||. ... ||  || |.||  |   |||||...|.. |....|  ..|   ....||..||.
lvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvyd

QRTSTIVMLTNLLEKDKkKCIEYWPSAGnHKRYGELEVIAREVKDEGSYVLRKFEVGKP---------DRTTNRLNITQYHYTIWPD-MGVPESSQPLLD
. .|..|.||.  .  | .. .|||  . ...|||..|   |.|     . |.| . |          . ...   ......| |.    || |.. |..
eeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalie

FRDIVKNA-----NPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCE
.|  |.       .  . ||..|..| |..|.| ...|.  .|..| |...|||...  .|. |  .|.  ..| .||..||..  |.
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1959-2223 7.4e-59 193.9 In-house 11-294 (301) alignment 
Range on Protein: 1959-2223
Range on HMM: 11-294/301.0
RMSRDGFEKEYKALLNKSDEGC-IGNNPENKPKNRYKNIITYDEHRVKLNKLPT--EPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRT
 .  ..||..||.| ...|. | .| . |||. ||.||| .||..|. |.. |.      .||||..||||.....|||.|||    | |||........
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

STIVMLTNLLEKDKKKCIEYWPSA-GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTT--------------NRLNITQYHYTIWPDMGV-PESSQP
..|||.||| |. |.|| .|||..  .....|...|   . .   ..|.|.. |   | .               .  ...|.. | ||. || .|    
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
|    |...  .  . ||..||||..|.|.|......  .|   ||  .|||. .. .|. .  .|.  .|| .||. . .. .
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
Y_phosphatase Protein-tyrosine phosphatase 2280-2508 8.4e-59 194.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 2280-2508
Range on HMM: 1-234/235.0
NAKKNRYPDRVPVDKFKPLLmtkGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWP--DSDKTN
| |||||.| .| || .  |    .. ...|||||.. .   .|.  ..||.|| ||..||||.||......|. |.. .     .| ||||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGSFTIELL-SDRTLTDTMTERVLKVTTSKKK-GERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNN-TSEKKFLVVCMDGVGASPTFLAANAAIDR
.|....||  .  . .. .| |.|... .|..  .|...||.| .|| |. ||.|. ....|...| ... ..... .|.|..||| . ||.|.......
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLA
......||....||.|||.|||.|..|| |.|.|....
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2280-2508 8.4e-59 194.2 In-house 1-234 (235) alignment 
Range on Protein: 2280-2508
Range on HMM: 1-234/235.0
NAKKNRYPDRVPVDKFKPLLmtkGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWP--DSDKTN
| |||||.| .| || .  |    .. ...|||||.. .   .|.  ..||.|| ||..||||.||......|. |.. .     .| ||||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGSFTIELL-SDRTLTDTMTERVLKVTTSKKK-GERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNN-TSEKKFLVVCMDGVGASPTFLAANAAIDR
.|....||  .  . .. .| |.|... .|..  .|...||.| .|| |. ||.|. ....|...| ... ..... .|.|..||| . ||.|.......
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLA
......||....||.|||.|||.|..|| |.|.|....
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2247-2519 1e-58 193.9 In-house 16-288 (318) alignment 
Range on Protein: 2247-2519
Range on HMM: 16-288/318.0
ADGRTEMSRQFEVLEymaPMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWD
..|....|...| |.   . |.| .  |   |||..|||| . .. |. . .| .. . . . |||||.. |   ||. .. .| ||  |. ||||.||.
esGelllseeyerls...rseetvtslkslepvnkaknryanilaydhtrvkLqmleg.eegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWe

YDIHTIIHLNEMD----STCGQYWPDSDKTNFGSFTIELLSDRTLTDtMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNN-
 .  .|. | ..       . .|||... ...|. ..|| .. .|.| .. | .||| .... .||. | .|  || |. || | ... .|. ||.. . 
qnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWp.degvpesgaslldlvrqvskaqq

TS-EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYAN
.| ..  .| |  |||   .|.| .. ..|......||.|  ||.||. |. .|   ..|||.||||  .  | .|...
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2278-2519 2.5e-58 192.2 In-house 7-250 (250) alignment 
Range on Protein: 2278-2519
Range on HMM: 7-250/250.0
PVNAKKNRYPDRVPVDKFKPLLMTKGdEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN---EMDSTCGQYWPDSDKTNF
| | .|||| | ...|. . .| ..    .. ||||||| ..   .. .. || || .|. ||||.|..... ||. |.   |.. |. ||||    ...
pqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaeky

GSFTIELLSDRTLTDtMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTS--EKKFLVVCMDGVGASPTFLAANAAIDRVR
|. |..|||. . .| .| |.||..  ||..||.. ||... || |  ||.     .|||..|  ..    ..  .| |  ||| | .|.| .| ..|..
Gdvtvsllskeefad.ytkrklklskakkaderivrqlhfvvWP.dkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

EDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYAN
..|.||.|  .|.||| ||..|. ||.| |.| ..  . |||. ||.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
0040438 (Phosphotyrosine protein) phosphatases II 2272-2510 6.1e-58 191.9 In-house 35-275 (317) alignment 
Range on Protein: 2272-2510
Range on HMM: 35-275/317.0
DQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDST----CGQYWP
 . ..||.| .|||||| .| |  .  |   |  . |.||||||. |.  .|.  ..|| || .||.||||.||......|. |.| .      | ||||
ysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

DSDKTNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTS-EKKFLVVCMDGVGASPTFLAANA
. .....| ||..|||  .  . .| |.|.|. .... .|..|...|.||| |  || |  .....| .|.... . ... || |..||| . ||.||  
lgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaayl

AIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
....... ..||...|||.||. |||.|  .| |.|.||.|. |
mleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
subfamily_PTPN1_pd Subfamily PTPN1 1982-2225 7.8e-58 190.5 In-house 27-274 (290) alignment 
Range on Protein: 1982-2225
Range on HMM: 27-274/290.0
GNNPENKPKNRYKNIITYDEHRVKLNKLPTepgaDYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGN
 ..|||...|||...  ||  |.||..  .    |||||....  . .  .| .||| .   . |||||.||.. ..||| ...||.. || .|||.  .
aklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

--HKRYG----ELEVIAREVKdeGSYVLRKFEVGKpDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNAN--PADSGPIIVHCSAGVGRTGTFI
     .     ....|..|.|    |..|..|. .  .| .  .|...||| |||.||||| . .|.|   |...     | || ..|||||.||.|||.
ekellledtklkvkliseerk..syytvrllelen.lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

TINCMIEMIEAEKK---IDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCE
 .....  ||....   .|. . . |.|| |  ..| ..| .| | ..|. ... 
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
0045450 (Phosphotyrosine protein) phosphatases II 2240-2510 8.3e-58 191.9 In-house 16-303 (307) alignment 
Range on Protein: 2240-2510
Range on HMM: 16-303/307.0
TWGTIKDADGRTEMSRQFEVLEYMAPMEsTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNDYINASFF--------DVEGRKNVHVCTQC
 .  .. .|..| . ..|| |  . ..   |.   ..||.| .||||.| .| |     |.. .....|.||||||.         |.  .|.  ..|| 
llvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLMSTVGDFWRLVWDYDIHTIIHLNEMDST----CGQYWPDSDKT-NFGSFTIELLSDRTlTDTMTERVLKVTTS-KKKGERQITQLQYLGWPNDSlVPR
|| .|| ||||..|......|. |.| .      | |||||.. . ..| ||..|||  .  | .| |.|.|| . ... .|..|...|.|||... || 
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhg.vpp

SKMDFFELLTQVDN---NNTSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKT---VDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
|  ...... .|..   ....... || |..||| ..||.||  .........|   ||...|||.||. |||.|  .| |.|.|..|. .
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2271-2516 5.2e-57 188.3 In-house 37-288 (305) alignment 
Range on Protein: 2271-2516
Range on HMM: 37-288/305.0
SDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN----EMDSTCGQYW
| . |.  .|..|||. . .. |. .  | .| ...||.||||||. |   ||. .. .| || .|| |||||.... ..||. |     . .. | |||
sidvgkkeankaknrlkeitlldddriiltek.eslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PDSDKT--NFGSFTIELLSDRTLTDtMTERVLKVTT-SKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNNTSEKK--FLVVCMDGVGASPTF
|.| .   .||.|..|| | .| .|  .|| ||... ...| .|...|.|   ||..  ||..   . .|. .| ..  ..|.   ||.| .||| . .|
pesktekkefgefsvelksektasd.yieRklkisiededkesrtvlqyqltdWPdhG.vpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

LAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQT
.| . |..|......||.|  .|.||..|...| .|..| |..|.|. .  . .|
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
0043336 (Phosphotyrosine protein) phosphatases II 2249-2510 9.1e-57 188.0 In-house 18-276 (278) alignment 
Range on Protein: 2249-2510
Range on HMM: 18-276/278.0
GRTEMSRQFEVLEYMAPmestGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYD
..| ....|| |  . .    ..   . || | .||||.| .| |     | .  ... |.||||||. |.  ...  ..|| || .||.||||.||...
lktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvkl.sllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

IHTIIHLNEMD----STCGQYWPdSDKTNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNT-S
..||. |.| .     .| |||| .. ...| ||..||.  .  |..| |.|.||  ... .|..|...||||| |  || |  .....| .|.. .  |
vttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavrealeds

EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
... || |..||| . ||.|.  ......  ..||...|||.||. ||| |  .. |.|.|..|. |
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRD_pd Subfamily PTPRD 2304-2517 4.6e-54 179.0 In-house 71-287 (564) alignment 
Range on Protein: 2304-2517
Range on HMM: 71-287/564.0
DEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN---EMDS-TCGQYWPDSDKTNFGSFTIELLSDRTLTDtMTERVLKVT
. ... ||||||| |   ...  . || || .|. ||||.||.....||. |.   |..   | .|||.......|..|..| .  .|.| .. | .|..
egdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeelad.yeirtfklk

TSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEKKFL-VVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELE
..|..  |...| ..  || |. || |  .. .|...| . |..... . | |  ||| . ||.. .| ..|..|.|||||.. ||.||| |. .|.. |
kkkssesreVrqFhFtsWP.dhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqtee

RYEFCYDVLAAYQDSVQTY
 | |...... . .. .| 
QYiFiheailealacgnte
0040439 (Phosphotyrosine protein) phosphatases II 2276-2510 6.6e-54 178.5 In-house 7-245 (249) alignment 
Range on Protein: 2276-2510
Range on HMM: 7-245/249.0
SLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDSDK
.||.| .|||||| .| |   . |   .. . ..||||||..|.  .|.  ..||.|| .||.||||..|...|..|. |.. .     .| ||||... 
llpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

TNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNT---SEKKFLVVCMDGVGASPTFLAANAAI
...| ||..|||  .  | .| |.|..| .... .|.....||..|| |  || |  |..... .|.. ..   .... || |..||| ..||.||  ..
leygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

DRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
..... ..||...||| ||. |||.|  .| |.|.|..|. .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 2279-2507 1.6e-53 176.6 In-house 42-273 (314) alignment 
Range on Protein: 2279-2507
Range on HMM: 42-273/314.0
VNAKKNRYPDRVPVDKFKPLLMTKGDEVdDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDSDKTnF
 | .|||. | .. |. .. |.|  ..  ..|||||.. |   | . .. || || .|| ||||||.|..  .|. |.|. .     | .|||.  .. .
enreknrsgdilaydrsrvflitidgdp.ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.y

GSFTIELLSDRTLTDTMtERVLKVTT--SKKKGERQITQLQYLGWPNDsLVPRSKMDFFELLTQVDNNNT-SEKKFLVVCMDGVGASPTFLAANAAIDRV
| . .||..  .|.. .  |...|.    .... |.. |.|.||||.   || |.  ...|. .|.. .  .. . .| |. | | . ||.| .  .| .
gdikvelvetellaelv.vrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi

REDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
.....||.| ||| ||.... .|.  |.| |.|||.
eregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Ptp69D_pd Subfamily Ptp69D 2248-2516 7.6e-53 174.6 In-house 19-291 (307) alignment 
Range on Protein: 2248-2516
Range on HMM: 19-291/307.0
DGRTEMSRQFEVLEYMapmESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDY
|    . . .| ||     |.  | . .    || ||||.| .. || .  | .|    .| |||||||      |. ... | |. .|.|||||.... 
dtdfglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkL.kkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

DIHTIIHLNEMD---S-TCGQYWPDSDKTNFGSFTIELLSDRTLTDtMTERVLKVTTSKKKG-----ERQITQLQYLGWPnDSLVPRSKMDFFELLTQVD
....|. | ...      | .|||. |....|.  ..| | .. .|  ..| |.|.. |...     .|...| .|.||. || ||..    ..|..|| 
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsd.yiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvr

NNNTS-EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQT
. .   .   .| |  ||| | .|.| .  .........||||  || ||. |. .|. || |.|.|  |. |..  .|
elyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2246-2516 7.9e-53 174.6 In-house 18-288 (319) alignment 
Range on Protein: 2246-2516
Range on HMM: 18-288/319.0
DADGRTEMSRQFEVLEYMAPMestgSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVW
.. | | . ..|. |.   ..    . .. | . | |||||.. ...|. .  |..  . |.. ||||||| |   ... .. || ||  |. ||||.||
astgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

DYDIHTIIHLNEM----DSTCGQYWPDSDKTNFGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNN
........ |...    .  . .|||. . ...| ....|.... | | .  ..   . | .   |.... ||. ||..  ||.. .   .|| .. .  
eeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhd.vPekatslldllkrirksr

TS--EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQT
    ..   | | .|||   ||.. .|...||.|. ..|.|| |.|||  |. .|.. | |.|.|..| .. .. .|
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0042113 (Phosphotyrosine protein) phosphatases II 2276-2510 9.4e-53 174.5 In-house 5-242 (245) alignment 
Range on Protein: 2276-2510
Range on HMM: 5-242/245.0
SLPVNAKKNRYPDRVPVDKFKPLLMTKGDeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMD----STCGQYWPDSDK
.||.| .||||.| .| |     |.  |    |.||||||. |.  ...   .||.|| .||.||||..|...|.||. |.| .     .| ||||....
llpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

TNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNT--SEKKFLVVCMDGVGASPTFLAANAAID
...| ||..|||  .  |..| |.|.||  ... .|......||.|| |  || .  .....|  |..     |... || |..||| . ||.||  ...
ltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.... ..|....|||.||. |||.|  .. |.|.|..|. .
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_CG7180_pd Subfamily CG7180 2257-2510 1.9e-52 172.8 In-house 19-289 (296) alignment 
Range on Protein: 2257-2510
Range on HMM: 19-289/296.0
FEVLEYMAPMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNdYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN
.. .  ..|  ..|  . |    | .|||... || |.....| . . | ... ||||.. |   .|. .. |. |  .||..|||||.| .|.... | 
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

EMDS---TCGQYWPDSDKTNFGSFTIELLSDRTLTDtMTERVLKVTTS----------KKKGERQITQLQYLGWPNDSLVPRSKMDFFELLTQV---DNN
.  .    . .|||   |...| . .|... ..... .. | .|.|             |  .| ....|.  |. .  || |   . ||. .|    ..
ktfdfakmypsywpnkskeqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrek

N---TSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.     |.  .||. ||.. |  .||..|... |.... ||.| |||.||.|||..|.. | | ..||||  .
vdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2279-2507 3.5e-52 172.3 In-house 48-275 (315) alignment 
Range on Protein: 2279-2507
Range on HMM: 48-275/315.0
VNAKKNRYPDRVPVDKFKPLL-MTKGDevDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPDSdKTN
 | .|||| .... || .. | ... |  .. ||.||.| |   .|. ....| |....|.||||||...|| .|. |...     . . .||||  |  
enkqknryiniiaydksrvqlpllend..phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kvi

FGSFTIELLSDRTlTDTMTERVLKVTTskKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSE-KKFLVVCMDGVGASPTFLAANAAIDRVR
.| .|. . |.    . .| | | |.   ..  |.. ||.|  || |. ||.. . . .|  .|   .|..    .| | .|||.. ||.. .| .|.. 
yGkitvtrkseev.nteytvrtlsvvf..gdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae

EDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
 .. .|.. .....|. | ..|. .|.|.| ||.|
aenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1984-2221 1.7e-51 169.7 In-house 35-276 (287) alignment 
Range on Protein: 1984-2221
Range on HMM: 35-276/287.0
NPENKPKNRYKNIITYDEHRVKLNKLPtEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHK
.  .  |||| ... .|. || | . . | |.||||| .. .|....||||.||| ||...|||..|.|.|.......|  .|. ..|| .|||      
elaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

RYGELEVIAREV-KDEGSYVLRKFEVGKPDRTTNRLnITQYHYTIWPDMGVPESSQPLLDFRD-----IVKNANPADSGPIIVHCSAGVGRTGTFITINC
| |   |.. .  . |  |  | . . . .    |. . |...  ||| ... ..  |. |       |  . . .. ||..||...|.||.|.....  
rvGGysvvlldydikePeygvralrlidletrearv.vkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

MIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
.... |   ..|| . .  .|..|| .||   |. ..||.|  .
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPRA_pd Subfamily PTPRA 2275-2510 2.1e-51 169.8 In-house 53-294 (330) alignment 
Range on Protein: 2275-2510
Range on HMM: 53-294/330.0
GSLPVNAKKNRYPDRVPVDkFKPLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMD----STCGQYWPDSD
 |   | .|||... .| | |. . ... . |.. ||||||| |   .|. .. .| |.  || ||||..|... .||. | |..    . | |||||  
askeenkeknrvvnilPyd.fsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

KTNFGSFTIELlSDRTLTDTMTERVLKVT----TSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEK-KFLVVCMDGVGASPTFLAAN
   .|  ..|.  | |..  .| | . |.    ....| .|...|. . .|| |  ||   .  ..|| .| . |  .     | |  ||| . ||.. .
lvtyGnirvev.edetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

AAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
| ..||. .. ||.| .|||||. || .|  .|.|||.| ||  |
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2265-2514 3.1e-51 169.4 In-house 33-291 (325) alignment 
Range on Protein: 2265-2514
Range on HMM: 33-291/325.0
PMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEvDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMD---ST
| . . . .   .| | .|||... |..|| .. | ||.|.  . ||||||..  . .|.| . .| || .|..|.|||| |.    .. |||.|     
psddgiakkvamkpenkaknrfknvvaldksrvvletkkdd.pssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdr

CGQYWPDS--DKTNFGSFTIELLSDRTLTDTMtERVLKVTTSKKKGERQITQLQYLGWP--NDSLVPRSKMDFFELLTQVDNNNTS----EKKFLVVCMD
| .|||.   .  .||.. ..| .  ...| .  |||.|   ||   | . |.|. .|.       | . . . .|. .|..  |.       .|| |..
cavywpkemgksktfGglevklrtieeisdyv.hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSV
||| . .|..  .|...| |.  ||||  ||.||| || .|.  ..| ..|. |. .  | 
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
0045098 (Phosphotyrosine protein) phosphatases II 2269-2510 3.2e-50 166.4 In-house 22-271 (278) alignment 
Range on Protein: 2269-2510
Range on HMM: 22-271/278.0
TGSDQKGSLPVNAKKNRYPDRVPVDKFKPLlmtkgdevddnDYINASFFDVEgrKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQ
 ..   . .. |..||||.| .|.|                ||||||. |.   ..  ..|| || ||| ||||..|...|..|. |.|        | |
pseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPDSDKTNFGSFTIELLSDRTLtDTMTERVLKVTTS----KKKGERQITQLQYLGWPnDSLVPRSK--MDFFELLTQVDNNNT--------------SE
|||...  ..| ||..|||  .| |..| |.|.||      .   .| .|.|.||.|| |  || .   . |.||| .... .               |.
ywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwp.dhgvpslpilksflellefirealkllaslllsslllldsg

KKFLVVCMDGVGASPTFLAANAAIDRVreDKTVDIFSAVKRLRKSRPG-VVDELERYEFCYDVLAAY
.. || |. ||| . |. ||   ....  ...||...||| ||. ||| .|  || |.|.|..|. .
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
0051429 (Phosphotyrosine protein) phosphatases II 2014-2221 9e-50 165.1 In-house 3-224 (272) alignment 
Range on Protein: 2014-2221
Range on HMM: 3-224/272.0
GADYINATFIDGYKK---ENAFIASQGPNAASLNDFWQMvYEQRTSTIVMLTNLLEKDKKKCIEYWP-----------SAGNHKRYGELEVIAREVKDEG
  .|||| ...|| .   ......|.||  .. .|||.. .|.. .|||.|... |... ||  |||           ..    .|| | |.  ...   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

SYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSqpLLDFRDIVKNanpadSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKID--------VF
 |.||.... .   ... . ....||| |||.|||...  ||.. ... .     .||..||||||..||||.. .  ... ...|  .|        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NFINEMRKRRAFMVQVQQQYEFIYETLLQW
....|.|..|. .|| ..||.|.|| ||..
eaveelraqrpgavqteeqylflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 1987-2226 3.3e-49 162.3 In-house 1-175 (182) alignment 
Range on Protein: 1987-2226
Range on HMM: 1-175/182.0
NKPKNRYKNIITYDEHRvklnklptepGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTnllekdkkkCIEYWPsagnhkryg
|..||||..|. ||  |          . ||||| ...|. . . ||| |||   ...||..|..|.. .|||.||         .  |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

eleviarevkdegsyvlrK-FevgkpdrttnRLNITQYHYTIWPDMGVPEsSQPLLDFRDIVKNanpaDSGPIIVHCSAGVGRTGTFITINCMIEMieae
                  . .            ...||.|. |||.|||.  . |||| ..|..    ..||..||||||||||||.. .  |...    
..................ell..........erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

kKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEK
 ...... ....|.||  ||.  .|| |..  ||.. .. |
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2252-2513 3.6e-49 162.5 In-house 22-286 (297) alignment 
Range on Protein: 2252-2513
Range on HMM: 22-286/297.0
EMSRQFEVLEYMAPMES-TGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVdDNDYINASFfdVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIH
... ...  |.  . |. . .. .    || .|.|| . .|.|. .  |   .|.  | ||.||||  |.| |. ...|| |  .|| |||..|.|... 
nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddp.dsDyvnasf..vkgnkhrlittqmPmkatvadfWamvldeqvs

TIIHLNE---MDSTCGQYWPDSDKTNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSLVPR-SKMDFFELLTQVDNNNTSEKK
||. ||.    |  | .||.|.  |.||. ...|||       . .| |.|| .| | .| . | |.. ||...   . |   . .|...| ..  ....
tivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae

--FLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDS
   || |. |||    .|. .  . .....|.||||  ||.||..|| .|   | |.| | ..  .  |
gPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2246-2517 6.1e-49 161.4 In-house 15-289 (290) alignment 
Range on Protein: 2246-2517
Range on HMM: 15-289/290.0
DADGRTEMSRQFEVLEYmapMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVD-DNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLV
 | |.. .  ||..|.     ||  . . |  . | ..||. . |. | ..  |  .... |  |.||||.. .    |. .. || |...|. |||.|.
hakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WDYDIHTIIHLNE---M-DSTCGQYWPDSDKTNFGSFTIELLSDRTLTdTMTERVLKVTTSKK-KGERQITQLQYLGWPNDSLVPRSKMDFFELLTQVDN
|. ..  |. | .   .   .| ||||||| ...| |.|.||...||. ...|| |.|. ... . ....||.|   |...  |.  .     .  ....
wqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

NN-TSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTY
.  . ..  .| | |.|| | .|.||. .|.... .  .|.|. .|..|  .|| |   ..|.. ....  | ||..||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0036282 (Phosphotyrosine protein) phosphatases II 2015-2216 8.5e-49 160.9 In-house 2-164 (174) alignment 
Range on Protein: 2015-2216
Range on HMM: 2-164/174.0
ADYINATFIDGYKKENAFIASQGPNAaslndFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSagnhkrygeleviarevkdegsyvlrkfevgkpDRT
 |||||...|..   . .||.||| |     ||.|..|.. .|.|||... |... ||| |||.                                 .|.
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

TNRLNITQYHYTIWPDMGVPESSQpLLDFRDIVKNANPA-DSGPIIVHCSAGVGRTGTFITINCMIEMIEaEKKIDVFNFINEMRKRRAFMVQVQQQYEF
  . .. ||.|. |||.|||..|. ||.| ..|..|    ..||..||||||||||||.. .  |. ... |. .|..... |.|. |  ||| ..||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IYE
.|.
lyy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2274-2510 6.1e-48 158.3 In-house 38-276 (315) alignment 
Range on Protein: 2274-2510
Range on HMM: 38-276/315.0
KGSLPVNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE---MDS-TCGQYWPD-
 .  ..| ||||| . .|.|. .  |    |.  |.||||||..      . ....| || ..| ||||.|..... ||. ...    |   | ||||| 
varetinfkknryknilPldsarvklevi.ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-SDKTNFGSFTIELLSDRTLTDtMTERVLkvTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNN-NTSEKKFLVVCMDGVGASPTFLAANA
 .| ..|||. .||||  . || .. | |  .| | .  |..|| |. .||.   |..    ...|. .|  . .. |  .|| |. ||| .  ..... 
kadsvefGsikvellsleadtd.gvarkl..vtrkseesrtvtqfqftewPdkG.vdkqtssllklikevkadngkkefsllvhcsaGvGrtGvviside

AIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
 ...... ..||.|  || ||. || .|   |.| | ||..  .
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
0037934 (Phosphotyrosine protein) phosphatases II 2276-2509 2e-47 157.2 In-house 6-240 (243) alignment 
Range on Protein: 2276-2509
Range on HMM: 6-240/243.0
SLPVNAKKNRYPDRVPVDKFKPLLmtkgdevDDNDYINASFFDVEGRknvHVCTQCPLMSTVGD----FWRLVWDYDIHTIIHLNEMD----STCGQYWP
.||.| .||||.| .| |     |       ...|||||.. .| .|     .||.|| .|| |    |||..|...|..|. |.| .      | ||||
llpenlsknrysdilpydhsrvkl.......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dsDKTNFGSFTIELLSDRTLTDtMTERVLKVTTSK-KKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDN---------NNTSEKKFLVVCMDGVGA
  .....| ||..||| ..| | .| |.|...  . .. .|......||.|| |  || |  |. ..| .| .         .. |... || |. ||| 
..gevtygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SPTFLAANAAIDRVredkTVDIFSAVKRLRKSRPG-VVDELERYEFCYDVLAA
. |..||   ....    .||...|||.||. ||| .|  .. |.|.|..|. 
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2246-2519 5.3e-47 155.2 In-house 15-286 (287) alignment 
Range on Protein: 2246-2519
Range on HMM: 15-286/287.0
DADGRTEMSRQFEVLEYMAPMESTGSdqKGSLPVNAKKNRYPDRVPVDKFKPLLMtkgdeVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVW
 | |... . || ||| .   |       .  . | .|||. . .. |... ||        ..|||||.| |    |. .. .. |...|. .||.|..
hakgnegfknqftvleqvtqredevt..hniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesPmfntarnfWklid

DYDIHTIIHL---NEMD-STCGQYWPDSDKTNFGSFTIELLSDRtLTDTMTERVLKVTTSKKKGE-RQITQLQYLGWPNDSLVPRSKMDFFELLTQVDNN
|  ...|. |   .| | . | ||||... . .| ..||||..   .. ..|| |.|. ..|.|. .|..| |.  |..   |.. .  .. .  .. ..
drnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

NTS-EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYAN
  . .   .| | |.|| | .|.||. .|...... ..|.|. .|. |  .|| |   |.|.| .|.. .| || .||..
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2269-2507 5.7e-47 155.6 In-house 49-287 (319) alignment 
Range on Protein: 2269-2507
Range on HMM: 49-287/319.0
TGSDQK-GSLPVNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNemDSTCGQYWP
 ..||.   |. |  |||. . .. || .  |  . . ..  ||||||| .   ||. .. .| ||  |. ||||..|.|.. ||. |      | ||||
nladqtfanldqnkdknriinilafdknvvkl.erliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywp

DSDKTNFGSFTIELLSDrTLTDTMTERVLKVTT-SKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQ---VDNNNTSEKKFLVVCMDGVGASPTFLA
   . . . | ... |  . |.  . | ....  .|.|. |.|||  .||||.   || . .|.. |. .   . . .  ... .| |  ||| . ....
lkivikeerfkvkvdsv.eetaeyvvrdielsedgkekdirkitqfhflGwpdvG.vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

ANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
 .. .||..|.| ||..  |. ||. |. .|..| .| |.|  |
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2275-2507 1.9e-46 153.8 In-house 20-251 (284) alignment 
Range on Protein: 2275-2507
Range on HMM: 20-251/284.0
GSLPVNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNemDSTCGQYWPDSDKTNF
  |. |  |||. . .. || .  |  . . ..  |||||||     ||. .. || ||  |. ||||..|.|.. ||. |   .  | ||||   . . 
anldqnkdknrighilafdknvvkl.erliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivike

GSFTIELLSDrTLTDTMTERVLKVTT-SKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQ---VDNNNTSEKKFLVVCMDGVGASPTFLAANAAIDR
. | ... |  . .. .. | ....  .|.|. |.|.|  .||||.   || . .|.. |. .   . . .  ... .| |  ||| . .... .. .||
erfkvkvdsv.eeseeyvvrdielsedgkekdirkirqfhflgwpdvg.vpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

VREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
..|.| ||..  |. ||. |. .|..| .| |.|  |
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN12_pd Subfamily PTPN12 2253-2510 3.6e-46 152.4 In-house 10-276 (290) alignment 
Range on Protein: 2253-2510
Range on HMM: 10-276/290.0
MSRQFEVLEYMA---PMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKpLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDI
....|. |  ..    .|.. | ..|. ..| ||||| | .| || . . ..| .|....|||||.|      |  .. .| ||  |. ||||..|....
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksr.velskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

HTIIH---LNEMD-STCGQYWPDS--DKTNFGSFTIELLSDRTLTDTMTERVLKVTTSkkKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTS
. ..    . |..   | .|||..  ....||.|...| ......| .. | |||...  | .|...|..|  || |  ||.|. . .||...| . ..|
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWP.DhgvPssaksllelielvrelqes

EKK-FLVVCMDGVGASPTFLAANAAIDRVREDKT---VDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
|.. ..| |  |||   | .| . . . ....|.   .|.|. | .||| |. .|   |.||. |  .| .
edaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1982-2222 1.7e-45 149.9 In-house 52-283 (290) alignment 
Range on Protein: 1982-2222
Range on HMM: 52-283/290.0
GNNPENKpKNRYKNIITYDEHRVKLNKlpTEPGaDYINATFIDGYKkeNAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPS-AG
 .|.| | |||||...  |  || |.     .| ||. | ...| |    || .||. ...  |.|.|| ......|||| .|.|. | || .|.|  .|
dkntefk.knrykdvvcndktrvilkd..GydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

NHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNAnpadSGPIIVHCSAGVGRTGTFITINCMIE
.   .||. |.  | .|. . . .|    .   .     .  ..   |||  |. |.  ||    |...|    |||..||||||.||||||..|.  ..
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglq

MIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWS
..   |..|. . .  .|. |.  |||. ||  . | ||.. 
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2279-2509 2.6e-44 146.2 In-house 42-274 (515) alignment 
Range on Protein: 2279-2509
Range on HMM: 42-274/515.0
VNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE---MDST-CGQYWPD--SDKT
.| ||||| . .| |. .  |    ..  ..||.|||.       . ....| |. ..| ||||||..... ||. ...    |   ||.||||  .|  
infkknryknilPydsvrvklevi.ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

NFGSFTIELLSDRTLTDtMTERVLKVTTSKKkgERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNN-NTSEKKFLVVCMDGVGASPTFLAANAAIDRV
.|||. .||.|  . |. .. | |.|. ...   | .|| .. .||.   ||.    .. |. .|  . .  .  ... |. |||    .....  . ..
kfGsikvelvsleactg.gikrkltvlkgdd..srtvtqfhfteWPdkG.vpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

REDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAA
.. ..||.|  |. .|. || .|   |.| | |...  
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_PTPRG_pd Subfamily PTPRG 2247-2510 2.7e-44 146.3 In-house 15-286 (563) alignment 
Range on Protein: 2247-2510
Range on HMM: 15-286/563.0
ADGRTEMSRQFE-VLEYMAPMESTGsdQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVW
||| . .|..|| . . ..... .   .. . | | .|||| . |..|. .  |    .. .. |||||.. |   ... .. || || .|. ||||..|
adgdigfseefealqsetiskdlda..ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiW

DYDIHTIIHLNE----MDSTCGQYWPDSDKTNFGSFTIELLSDRTLTdTMTERVLKVTT--SKKK----GERQITQLQYLGWPNdSLVPRSKMDFFELLT
.   ..|. . .    .   | .|||  .  ..|.... | .  .|. . |.| |..     |||     |....| .|  ||.   || ...       
eqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevla.lytvrtlviknlklkkkkqcdteklvrqyhytkWPd.hgvPehslpvLifvk

QVDNNNTSEK-KFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
. .  | .|    .| |  ||| . |... .. . .......|..|  .|..|  |. .| . | | | .|.|   
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
0049772 (Phosphotyrosine protein) phosphatases II 1982-2221 5.4e-44 146.5 In-house 41-279 (314) alignment 
Range on Protein: 1982-2221
Range on HMM: 41-279/314.0
GNNPENKPKNRYKNIITYDeHRVKLNKLPTEpGADYINATFIDGYkkeNAFIASQGPNAASLNDF----------WQMV--YEQRTSTIVM---------
.. ..|. ||||..|. .| .||.|..|| . | ||||| ..||.   ..|||.|||.   ..||          |.||  ..... .|||         
adlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTNLLEKDkkkcieywpsagN---HKRYGELEviarEVKDEGSYVlrkfevgkpdrttnRLNITQYHYTIWPDMGVPeSSQPLLDFRD
            |..| ..             |    ... .|.    |. ......                .. .|... .|| ..| ... ...| .
lsrLdaAlgKtpllildgng............neptaadlellk....eelydpelf..............erlgikylripvpDgsap.lledfdefle

IVKNAnpADSGPIIVHCSAGVGRTGTFITINCMIEMIeaekKIDVFNFINEMRKRRA-----FMVQVQQQYEFIYETLLQW
....|   . ||..|||.||.||||||... ...       ....   ....|..|       ... ..|||||.| ||..
fieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
0043147 (Phosphotyrosine protein) phosphatases II 2012-2216 6.3e-44 145.1 In-house 2-155 (172) alignment 
Range on Protein: 2012-2216
Range on HMM: 2-155/172.0
EPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLlekdkkkcieywpsagnhkrygeleviarevkdegsyvlrkfevgKP
..| ||||| ..|.| . . ||| |||    |.|||.|..|.  ..||.||.|                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

DRTTNRLNITQYHYTIWPDMGVPeSSQPLLDFRDIVKN-ANPADSGPIIVHCSAGVGRTGTFITINCMIemieaeKKIDVFNFINEMRKRRAFMVQVQQQ
|..    .. ||.|. |||.||| ... ||.| ..... ..  ..||..||||||||||||.. .  |.      ....... ....|..|  .|| ..|
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YEFIYE
| |.|.
yrflyy
subfamily_PTPN6_pd Subfamily PTPN6 2245-2515 8.1e-44 144.8 In-house 20-301 (306) alignment 
Range on Protein: 2245-2515
Range on HMM: 20-301/306.0
KDADGRTEMSRQFEVLEYMApMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMtkGDEVDDNDYINASFFD--VEGRKNVHVCTQCPLMSTVGDFWR
..  ... .. .|| |. .. .... | ..|. | |..||||   .|.|. .  |    ..| ..|||||.. .  |.| .. .. ||  | .|| ||||
eeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

LVWDYDIHTIIHL-NEM---DSTCGQYWPDSD-KTNFGSFTIELLSDrTLTDTMTERVLKVT-TSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQ
.||. . . |. . .|.    . | .||||.  |...|. ... .|. . ... . | |.|. ..||| ||.. |...  ||. . ||...  . ..|..
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhg.vpkdpgavLdfled

VDNNNTSEK-----KFLVVCMDGVGASPTFLAANAAIDRVRE---DKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQ
|.... . .       .| | .|.|   ||.  .. .. ...   |  .|| ..|| .|. | |.|   . | | | ....| .. .
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1983-2221 1.6e-43 143.6 In-house 29-258 (267) alignment 
Range on Protein: 1983-2221
Range on HMM: 29-258/267.0
NNPENKPKNRYKNIITYDEHRVKLNKLPTEpgadYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKcieYWPSA-GN
   .|. .||. . . ||. || | .   |    ||||....|||..||||. |.|   .  ||.... .|. ..||.||.  . . ..   .||   |.
iaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPkmgq

HKRYGELEVIAREVKDEGSYVLRKFEVGKPDRttNRLNITQYHYTIWPdmgVPESSQPLLD--FRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMI
 |.| .| |     |.|  | .  .|.   .   .  |.| |.|  |    .    .| |   |  . ||     . |..|.||.||||.|||..|. ..
akkyqdltvehslekeendyqiitlelkfkne..sahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsql

EMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
| .  |   |.|.|. ..|..|  .|.....| .|.|.| ..
eraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN9_pd Subfamily PTPN9 2253-2511 7.6e-43 141.6 In-house 18-290 (297) alignment 
Range on Protein: 2253-2511
Range on HMM: 18-290/297.0
MSRQFEVLEYmapMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTI
.|.... .     .. .|  ..  |..| .|||| | . .|. .  | .| || .  |||||.| |   .|. .. || ||  || ||||.||. .. .|
lskeyaeirn...epveGtflasklranleknrytdvlcydetrvvl.akvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

IHL---NEM-DSTCGQYWP--DSDKTNFGSFTIELLSDRTLTDtMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTS---
.      |.    ||||||  . . ..||..... .....  |  ..|||... .|.. .|..|  |.|.|| |  ||.| ......| .| .. ..   
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleiknvkteesrkvthfqflsWP.dyGvPssaaslldvlekvrekqalavk

-----------EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQ
           .   .| |  |.| . || . . ...|..|  |||.. .||.||. |   .   |.|||||  .  | 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0046846 (Phosphotyrosine protein) phosphatases II 2009-2220 9.7e-43 141.3 In-house 6-171 (176) alignment 
Range on Protein: 2009-2220
Range on HMM: 6-171/176.0
LPTEPGADYINATFIDGYKkenaFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRygeleviarevkdegsyvlrkfev
|  ... ||||| .|.|..    .|| |||   .| ||..|..|.. ...|.||.. |... ||  |||   ...                         
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

gkpdrttnrlnitQYHYTIWPDMGVPESsQPLLDFRDIVKNANPADsGPIIVHCSAGVGRTGTFITINcmieMIEAEKKIDVFNFINEMRKRRA-FMVQV
             ||... |||.|||.. . ||.. .....|  .. ||..||||||.|||||.. .     ..| || ..|.. . ..|..|  ..|| 
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

QQQYEFIYETLLQ
..||.|.|| .|.
peQyrflyefell
subfamily_PTPN3_pd Subfamily PTPN3 2274-2513 1.4e-42 140.5 In-house 35-278 (280) alignment 
Range on Protein: 2274-2513
Range on HMM: 35-278/280.0
KGSLPVNAKKNRYPDRVPVDKFKPLLMTKgdevdDNDYINASFFDVE--GRKNV--HVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQY
.  .| |..|||| | .| |. .  |        ..|||||.. ..|  . . |  .. || || .|. |||..||. ....|. | ..       | ||
aarkpenlsknryrdilpydatrvklkes.....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPDS-DKTNFGSFTIELLSDrTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNN-TSEKKFLVVCMDGVGASPTFLA
||.. |....|.|.... ..   | ..  | | .. ...| ||.|.||||| || |. || .. ||.|....| .   ..|.  .| |  |.| .  ...
WPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWp.dhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

ANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEF-CYDVLAAYQDS
 . |.  . . . | .   |...|  |  .|.  ..|.| |  .|..|...
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeei
0049260 (Phosphotyrosine protein) phosphatases II 2022-2216 1.6e-42 140.1 In-house 1-144 (152) alignment 
Range on Protein: 2022-2216
Range on HMM: 1-144/152.0
FIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWpsagnhkrygeleviarevkdegsyvlrkfevgkpdrttnrlnit
|||||.. ..||| |||   .|.|||.|..|.  .||||||.|||..| || .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIemieaeKKIDVFNFINEMRKRRAFMVQVQQQYEFIYE
||... |||.|||..|| ||.. .... ..  ..||..||||||||||||.. .  |.      .......... .|..|  .|. ..|..|.||
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPRB_pd Subfamily PTPRB 2246-2509 1.6e-42 140.5 In-house 20-283 (293) alignment 
Range on Protein: 2246-2509
Range on HMM: 20-283/293.0
DADGRTEMSRQFEVLEYMapmESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVW
 ||  ...| ..| |. .   ... . .. .|.||..|||| . .| |. .  |..  .. ...|||||.. .    .. .. || || .|| ||||.||
kadsdlrfseeyeelkav...gkdqavkaaelavnraknrytnilpydhsrvkLaal.kdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvw

DYDIHTIIHLNEM----DSTCGQYWPDS-DKTNFGSFTIELLSDRTLtDTMTERVLKVTTskKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDN-
.   ..|. | ..       | .|||.  . ...|. ...|.....| .  . | ||..   .| ||...|.... || |  || .   . ... .|.. 
ekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.edwvirelkiek..ekeerkvrqyhftsWp.dhgvPektktlldfvrtvrea

--NNTSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAA
  ...|..  .| |  ||| . ||.| .  .....|. .||||. | .||..|  .|   ..| | .... .
iektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1985-2224 1.2e-40 134.1 In-house 46-289 (305) alignment 
Range on Protein: 1985-2224
Range on HMM: 46-289/305.0
PENKPKNRYKNIITYDEHRVKLNklPTEPgADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHK-
 ... |||||..   |. ||||.  .. |  .|| | ..    . . || .| |   .  ||| | ....  .| || |||||  |||.||..|  ... 
aqeagknrykdvgcldnnrvkle..gpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

RYGElEVIAREVKDEGS----------YVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDfrdIVKNANPAdSGPIIVHCSAGVGRTGTFI
 . | .     || | |           .... ..      .. . .|.||.  ||| ||| . . .|.   ....| |.  |||.||||||.||||. .
efee.kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlaile...llekarps.kgpivvhcsagigrtgsvv

TINCMIEMIEAEKKIDVFN-FINEMRKRRAFMVQVQQQYEFIYETLLQWSHC
 .. ... . | ..|.  .  .. .|..|   .| ..|| |... .|.. . 
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1956-2222 1.3e-40 133.8 In-house 4-269 (281) alignment 
Range on Protein: 1956-2222
Range on HMM: 4-269/281.0
KAKRMSRDGFEKEYKALLN--KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNK-LPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYE
 ...|. | |..|.  |     ||   . |.| |. |||| ||   |  ||.|.  .| .  .||| | .|     .  .| .|||.  .  |||.|...
ssqkmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwq

QRTSTIVMLTNLLEKDKKKCIEYWPSAG-NHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTtnRLnITQYHYTIWPDMGVPESSQPLLDfrdIVKNAN
. |..|||| ..|| ...|| ||.|       .. .| |   .   . | |  ....     |  || ||.. .  |||  |||||. .|    |...  
enttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeget..rl.ithwlwkewpdwqvpessevmlk...ilrkir

pADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKI-DVFNFINEMRK-RRAFMVQVQQQYEFIYETLLQWS
 | | | ..||||||||.||.....  .. | .   . |. . .  .|   ||  ||  ||| .|.. ||.. 
.arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2274-2512 4.6e-40 132.5 In-house 35-277 (281) alignment 
Range on Protein: 2274-2512
Range on HMM: 35-277/281.0
KGSLPVNAKKNRYPDRVPVDKFKpLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHL-NEMDS---TCGQYWPDS
    . | .|||| . |  |. .   .|. .|  ..|||||.| .    .. .. || |. ... .||..||......|. . .|...    | .|||| 
askadenvlknrYsnivaYDatr.vkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

D-KTNFGSFTIELLSDRTlTDTMTERVLKVtTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEK--KFLVVCMDGVGASPTFLAANA
. ....| .|.. .. .. . |. ||..|. . ..  .|...||.|. || |  || . ....|  ..| . .....   ... |  ||| . |..| . 
nselkygdvtvkstaeee.katyierkfkl.eresgetreveqlaytaWP.dhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr

AIDRVRE-DKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQD
....| .  ...|.   |. |||.|  .|  . .||| | ..  . |
lvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0044763 (Phosphotyrosine protein) phosphatases II 1999-2219 5.1e-40 132.3 In-house 2-168 (178) alignment 
Range on Protein: 1999-2219
Range on HMM: 2-168/178.0
YDEHRVKLNKLPTEPGADYINATFIDGYkkenAFIASQGPnaaslNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNhkrygeleviarevkde
.|..||.|..|. ....|||||..|...     ...|..|      |......|.  ..||.||. ||  . ||..|||.  .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

gsyvlrkfevgkpdrttnrlniTQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMieaekKIDVFNFINEMR
                       ||... .||.|||.... .|.| .....| . . ||..|||||||||.||.. .  |...     ...... |...|
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

KRRAfMVQVQQQYEFIYETLL
.||  .|. . |....||  |
erRp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1963-2221 1.4e-39 130.9 In-house 16-276 (307) alignment 
Range on Protein: 1963-2221
Range on HMM: 16-276/307.0
DGFEKEYKALLNKSDEGCIGN-NPENKPKNRYKNIITYDEHRVKLNkLPTePGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVML
. .  |.. | .|. ||   .    |  ||||...   |  |. .. ..    .||| | ..    | . ||..|||  ..  .|| |. ...  ...||
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNLLEKDKKKCIEYWPS-AGNHKRYGELEVIaREVK---------DEGSYVLRKFEVgkpDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKnan
 ...|  | || .|||   |... .||       |.         ||    . ...|   | . .   |... .. ||| |||.     ... . |.   
ckvielakikceqywpleegqklvfgeapnt.isvanlgakklapdedlinvttlkv...dwaqksrtiqhlqwenwpdrgvpqinltainlleavr...

pADSGPIIVHCSAGVGRTGTFITINCM-IEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
  |  |..|||||||||.|| ..|  .   ||. .   |. ....|.|..| . .| . || ...  ||..
.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2265-2514 1.7e-39 130.6 In-house 15-271 (274) alignment 
Range on Protein: 2265-2514
Range on HMM: 15-271/274.0
PMEStgSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNDYINASFFD-VEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIH---LNEMDS
|..   . .. ... ...|||| . .| .. . || ..  | .| .|||| .    .......| || ||..|| ||||...  ... |.    |.|.. 
Plnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

-TCGQYWPDSDKT----NFGSFTIELLSdRTLTDTMTERVLKVTTSKKkgERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEKKF----LVVC
  | .|.||. ..    ..| . |.  .  . ..  . | | .  ...  ||...   |  || |  .|..   ...|...|......|..     .| |
qkCavyfPdaedyeiserygdveikvek.iverndysvrklvlkyler..ersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhC

MDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSV
  |.|    |.|.. |. ..||...||... |  ||  | |.|.. |.||. . .|. |.  .
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1961-2219 4.2e-38 126.0 In-house 17-268 (288) alignment 
Range on Protein: 1961-2219
Range on HMM: 17-268/288.0
SRDGFEKEYKALLNKSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNklptEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVM
. .| .|||.   |.. .  | .  .|  ..||.|.   |  ||||.    .    ||.|  .   | .. .| .| |  . .. .|.|. |.    |||
aveglkkeyrdspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

LTNLLEKDKKKCIEYWPS-AGNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANpadsGPII
|..|||| |.|  ||.||  |.. |.| |  . .. ...   ...   .     . ..  . . |.  |.| ||||. .. | . ...|. .     ||.
lcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPiv

VHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
||.|||||||||.| |  ..|..  .  . . ......|. |   .|...|| ...  .|
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_PTPN14_pd Subfamily PTPN14 2251-2510 6e-38 125.5 In-house 20-295 (300) alignment 
Range on Protein: 2251-2510
Range on HMM: 20-295/300.0
TEMSRQFEVLEYMAPMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGDEvdDNDYINASFFD--VEGRKNVHVCTQCPLMSTVGDFWRLVWDYD
 | .. |   | .....  .  . ..||.||.|||..| .| .. .  |..  ..  ...|||||     | |..  .. .| ||  || |||..||. .
leegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqg

IHTIIHLNEM----DSTCGQYWPDS----DKTNFGSFTIELlSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDN-
.. |. | |        . .|.|..    .. .|| | .     .. .|... . ||.     | ||..  |||  ||..  ||.   .|.. | .|.  
vqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt.kfsedsdsvittglklkhlpskeertvwhlqytDWpdhg.vPeDvkgflsyLeevqsv

--NNTSEK-------KFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
  . .||.         || | .||| .   . ..  |  .  ....|| ....|||. |  .|. | .|.| |.||  |
rrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1987-2227 1.4e-37 124.2 In-house 35-275 (285) alignment 
Range on Protein: 1987-2227
Range on HMM: 35-275/285.0
NKPKNRYKNIITYDEHRVKLNKLptepGADYINATFIDGY-KKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPS-AGNHKR
|   ||| ..   .| || |..       ||| |...    | ....|..|||   .|.|||.|.|... . ..||  |.|   .||  |.|   |.  .
npdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGELEVIAREVKDEG--SYVLRKFEVG-KPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADSgPIIVHCSAGVGRTGTFITINCMIEM
.|. |.   |.|.|     .|  . |    | ... | . . .   |||   || ..|....   ||. || .  || |||||||||| ||. |.     
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyatir

IEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCEKV
|  . .|.... . |||  |   || . |. |.|  |...   | |
imenpniemldivremramrfqavqshmqflflyvvlmeyfigegv
subfamily_PTPN23_pd Subfamily PTPN23 2246-2510 1.4e-37 124.1 In-house 10-279 (288) alignment 
Range on Protein: 2246-2510
Range on HMM: 10-279/288.0
DADGRTEMSRQFEVLEYMAPMEsTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMtkgdeVDDNDYINASFF-DVEGRKNVHVCTQCPLMSTVGDFWRLV
  ||.|.. ..|. ||     | . .       ....|||. | .| |. .  |         .|||||||  |.       ..|| || ||..|||..|
mldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WDYDIHTIIHLN---EMDST-CGQYWPDS--DKTNFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVD
..    .|. |    |.. . . .||| .  . ..|| ... | | |. |.|. |||||..| ...  .... ||.  ||.   || |  .....| .|.
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletldadavksvshlqltsWpelG.vPasPetllqfldeve

N-----NNTSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKT-VDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.     .. |..  .| |  ||| . .|    ||.  .....  .||   |.|||. |  .| | |...|.|..   .
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2279-2517 2.6e-37 123.2 In-house 37-284 (287) alignment 
Range on Protein: 2279-2517
Range on HMM: 37-284/287.0
VNAKKNRYPDRVPVDKFKPLLMTKGDEvdDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHL-NEMDST---CGQYWPDSDKT-N
 ..||||| | .|.|. . || ..|.     ||||| .     ... ....| |. .||.||||.|..    ..| .  |.. .   | .|||. ..   
aavkknryadvlPiddtrvllsaegel..GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmr

FGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSLVPR-SKMDFFELLT----QVDNNNTSEKKFLVVCMDGVGASPTFLAANAAI
 | ... ||.   .    . | |..   . .  | . ||..| ||...| |    .  | |      ..  . .     .| .  |.| | ..||  . .
vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

DRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY-QDSVQTY
.|  .   ||.  .| |||. | ..|    .. . |. |..| .   | |
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqly
subfamily_PTPN13_pd Subfamily PTPN13 2253-2507 1e-36 121.6 In-house 13-265 (273) alignment 
Range on Protein: 2253-2507
Range on HMM: 13-265/273.0
MSRQFEVLEYMAPMESTGSDQKGSlpvNAKKNRYPDRVPVDKFKPLLMTKGDevddndYINASFFDVEGRKNVH--VCTQCPLMSTVGDFWRLVWDYDIH
 . .|. |. . |.... . .| .   | .|||| . .|.|. .  |  .|       |||||.  |.  |. .  . .| ||  || |||..||. . .
Paeefkelrelkpldtcevgkkke...nkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

TIIHLN-E---MDSTCGQYWPDSDKTNF---GSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNNTS
 |. .  |       | .|||.| . .    . ...|||      |... | |.|. |. .  |....|..  ||. . ||.| ... .....| . .|.
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqk.ldgfvvralavkdsesgesrevahlnfvkwPdhg.vPssaaellqfvaevrrlqtd

EKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
.   .| |  |.| | |... ..... .  || .|.   |..||. | |||   ..| |.| ..
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
0051082 (Phosphotyrosine protein) phosphatases II 2014-2218 1.2e-36 121.0 In-house 2-149 (151) alignment 
Range on Protein: 2014-2218
Range on HMM: 2-149/151.0
GADYINATFIDGYkkenaFIASQGPNAaslnDFWQMVYEQRTSTIVMLTNLLEKDkkKCIEYWPSAGnhkrygeleviarevkdegsyvlrkfevgkpdr
  ||||.....|.     ...|.|| |    ||.....|.  .|||.|... | .  .| ||.|..|                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ttnrLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNanpADSGPIIVHCSAGVGRTGTFITINCMIEMieaekkIDVFNFINEMRKRRAFMVQVQQQYEF
    ......... ||| |.|.| . .|.| ... .    ..||..||||||.|||||.. . .|...      ....  ..|.|..|  .||  ||. |
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IYETL
..  |
qlfal
subfamily_ptpA1_pd Subfamily ptpA1 1976-2183 1.4e-36 121.2 In-house 36-257 (418) alignment 
Range on Protein: 1976-2183
Range on HMM: 36-257/418.0
SDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKeNAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEY
  |   |..  |  |||| ||.  .  ||.|.|.  . |.||||| .|||    . ||..|||   .. |||.||.|.|   ||||.   |. . ||  |
psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPSAGNH---KRYGELEVIAREVKDEGSYVLRKFEV---GKPDRT---TNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNAN----PA--DSGPIIV
||          ||. . .      |   |..  |     .  |     .  .||||.|  |||  .|. .||. ..   . | .    |.     ||||
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGVGRTGTFITINCMIEMIE
|||||||||||| |   |.. ..
hcsagvgrtgtfctavimmkkld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1954-2225 1.5e-36 120.5 In-house 18-293 (310) alignment 
Range on Protein: 1954-2225
Range on HMM: 18-293/310.0
VIKAKRMSRDGFEKEYKALLNKSDEGCIG-NNPENKPKNRYKNIITYDEHRVKLnKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYE
.| ....  .|. |.|. |  | |         ..  |||| ...  |. |||| |.      ||| | ..      ..|| ||||   .. |||.|...
iiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifq

QRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYGELEVIA-REVKDEG-------SYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFR
.|. .|..| .  |. . ||. |||| |  . || . |    |  .|        ..|  .  | .     . | ..  ..  |||.|||.     .  |
eraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqr

DIVKnanpADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSHCE
 . .       || .||||||..|... ....  |. ..  .|.|. . . |..|.||  .| . || .|    . ... |
llaq....vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarge
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1987-2221 3.2e-36 119.5 In-house 55-288 (305) alignment 
Range on Protein: 1987-2221
Range on HMM: 55-288/305.0
NKPKNRYKNIITYDEHRVKLNKLPtepGADYINATFIDGY-KKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRY
.. ||||...   |.  |||.| .    .||| | ..      |. ||..|||   ....|| || ...   |||| . .|  | || .||| |   |. 
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GELEVIAREVKDEGsYVLRKFEVG--KPDRT---TNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANpadsGPIIVHCSAGVGRTGTFITINCMIE
    ..  .|      . |  |.     . |    ... . . ..| ||| |||      |..   .. ..     ||.||||||.||||| ..|. ..|
lksgivvenvsgsk.pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyile

MIEAEKKID-VFNFINEMRKRRAFMVQVQQQYEFIYETLLQW
 |  .|.   . .... .| .||| .| . || ||.  .|..
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_PTPRN_pd Subfamily PTPRN 2249-2508 7.8e-36 118.3 In-house 27-289 (297) alignment 
Range on Protein: 2249-2508
Range on HMM: 27-289/297.0
GRTEMSRQFEVLEYMAPMESTgsDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASF-FDVEGRKNVHVCTQCPLMSTVGDFWRLVWDY
 .. .....| |      .||   . .. . |.||||. . .| |. .  | ..  . ...||||||. .| . |. ... ||.|| ||| |||..||. 
nkdrlekewealcayeaepst..kevakaeknvkknrskavlpydhsrvklkee.asaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

DIHTIIHLNEMDS----TCGQYWPDSDKTNFGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNNTS
 .  |..| ...      | .||||  .  .. . ..|.|.   .|    | . .   ...  | .||. .| ||. . || |   ..|.  .|.     
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeeg.vPasaksllefrrkvnksyrG

E-KKFLVVCMDGVGASPTFLAANAAIDRV-REDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLA
     .| |.||.| . .... .  ..|. .  | .|| .... ||  |||.|   ...||.. ..|
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2278-2519 8.3e-36 118.2 In-house 38-301 (301) alignment 
Range on Protein: 2278-2519
Range on HMM: 38-301/301.0
PVNAKKNRYPDRVPVDKFKPLLMTKGD-EVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMD----STCGQYWPDS--D
  |.. ||. . ...|. . .| .| . ..  ..|||||. |   .|.  . .| |. .|. |||||.|..   .|. . ...    | | ||||.|  .
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

KTNFGSFTIELLSDRTLT----------------DTMTERVLKVTTSKkkGERQITQLQYLGWPNDSLVPRSKMDFFELLTQVDNNNTSEK-KFLVVCMD
...|| ||..| .. ..                 .. .|| .||...|    ....|||   ||.| .|.  ..    .  ..  ..  .. . .| | |
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSd

GVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSVQTYAN
.|. | .. . . ... .. .  ||.|  .|..|.|.||.|  || | . |||.  |    .||||
tVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
PTPc_DSPc_SM00012 2120-2219 1.9e-35 116.6 In-house 2-104 (105) alignment 
Range on Protein: 2120-2219
Range on HMM: 2-104/105.0
ITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPAD--SGPIIVHCSAGVGRTGTFITINCMIEMIEAE-KKIDVFNFINEMRKRRAFMVQVQQQYEFIYE
...|||| |||.||||.|...|.. . ||. . .   |.|..|||||||||||||... ......|.| |..|.|....|.||.|. ||| ..|| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLL
 ||
all
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2278-2507 6.4e-35 115.4 In-house 31-262 (283) alignment 
Range on Protein: 2278-2507
Range on HMM: 31-262/283.0
PVNAKKNRYPDRVPVDKFKPLLMTKGDevddnDYINASFFDVE---GRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPDSD
  | .|||. . ||.|...  | ..       |||||.|  |.    ... .. .| ||  || |||..|.| .| .|. | ..    .  | ||||   
denkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

KTNFGSFTIELLSDRTlTDTMTERVLKVTTS-KKKGERQITQLQYLGWpnDSLVPRSKMDFFELLTQVDNNNTSEKK--FLVVCMDGVGASPTFLAANAA
  ..| ||. |  . |  .... . | . ..   | .  ..  |. .|   .  . . .. .  . .|  . | .||   .| |  |.| . .|.|| |.
sedyGeftvtlrkett.snsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

IDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
.. .. .  ||.|. || .|. |...| .|..| . ... 
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN1_pd Subfamily PTPN1 2273-2505 1.4e-33 110.8 In-house 25-265 (290) alignment 
Range on Protein: 2273-2505
Range on HMM: 25-265/290.0
QKGSLPVNAKKNRYPDRVPVDKFKPLLmtkgdEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPD
..  || | ..||| |  | |. .  |     | .||||||||....|  |  .. || || .||. ||..||. . .... ||..       | |||| 
reaklpenrnlnryrdvspydhsrikl.....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

SDK---TNFG--SFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEK---KFLVVCMDGVGASPT
 ..     .   .....|.|  . ... | |.|...  | .  |.|..  |. || |  ||.|   |...| .| .  .  .     .. |  |.| | |
geeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwp.dfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FLAANAA---IDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYD
|  ...    |..  . ..|||   .  ||| | |..   .. .| | 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2018-2211 3.2e-33 109.8 In-house 78-270 (301) alignment 
Range on Protein: 2018-2211
Range on HMM: 78-270/301.0
INATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHK----RYgELEVIAREVKDEGSYVLRKFEVGKPDR
| | .|.   . . |||.|||  .. .||| |.      .||||.. .|| ..|| || |.  ..|    |. ....  .|.  . . . |..||    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf.kikiknkelilnkkiskrtlevedstg

TTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANpadsGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQY
  .   .| | |. |.| |||.|   | |. ..||...     ||.||||||.||. .||. ...   .||...|.. . ....|..|   || ..| 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2248-2512 7.1e-33 108.7 In-house 3-260 (267) alignment 
Range on Protein: 2248-2512
Range on HMM: 3-260/267.0
DGRTEMSRQFEVLEYMAPMESTGSDQKGSlpVNAKKNRYPDRVPVDKFKPLLMTKGDEvddndYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDY
| ..|. ..|| .. ... .|| |   ..   |...||. | .| |. .  | || .|     |||||. .   .|| .. || ||  |..||. .. |.
deeceiekefelikkisdtsstisqsiae..knqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdq

DIHTIIHLNEM-DSTCGQYWPDS--DKTNFGSFTIELLSDRTLTDTMTeRVLKVtTSKKKGERQITQLQYLGWPNDSLVPRSKMDFFELLTQVDNNNTsE
.. .|. |         ..||    .  ..  .|.|   ..   |     .|..   |..  ...|   |  |  ..        .| .|.. . .|  .
kvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqi.itlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqleng.n

KKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQD
. ..| | |||| | ||| ... ..|.... ..|||  ....|. |.|.|| .||| .....|| | .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1964-2223 3.3e-31 103.1 In-house 20-277 (312) alignment 
Range on Protein: 1964-2223
Range on HMM: 20-277/312.0
GFEKEYKALLNK-SDEGCIgNNPENKPKNRYKNIITYDEHRVKLNKlptePGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLT
 . |||||. |  ||  |       |  ||| ||  .|  |  |          || | |.    | . |...|||   .   |||..    ...|..|.
qltkeykavgnivsdsect.aflkfkdlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

NLLEKDKKKCIEYWPS------AGNHKRYGELEV---IAREVKDEGSYVLRKFEVgKPdrTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNanpa
 ..|   .|| .|           .|. | |      |    ||  .. . |  | |   | .  .. .| .. ||| |.|.| .  | .   ||.    
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvv.ka..tgqesklnhyqwaswpdhgmpdscdtalrllsavkk....

DSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWSH
|  |.| |||||||||||.. |. ||  .   .| .| .    .|| ||  |.|  || .   ..|.. .
dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0041856 (Phosphotyrosine protein) phosphatases II 2280-2509 3.5e-31 103.6 In-house 1-169 (182) alignment 
Range on Protein: 2280-2509
Range on HMM: 1-169/182.0
NAKKNRYPDRVPVDKFKpllmtkgdevdDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNemdstCGQYWPdsdktnfgsfti
| .||||.| .|.|              |.|||||....   . .  ..|| ||.||| ||.|......|.||. |.     . .|||            
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp............

ellsdrtltdtmtervlkvttskKKGERQITQLQYLGWPNDSLVPrsKMDFFELLTQVDNnntSEKKFLVVCMDGVGASPTFLAANAAIDRvredkTVDI
                       .. ||...|..||.|| ..  .    ...... .| .   .... || |. ||| ..|. ||   . .      |..
.......................ellerlgiqylylpwpDhgvpd..ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

FSAVKRLRKSRPGVVDELERYEFCYDVLAA
..||| .|. |||.|  .. | |....|  
eeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2280-2507 1.4e-30 101.1 In-house 48-275 (439) alignment 
Range on Protein: 2280-2507
Range on HMM: 48-275/439.0
NAKKNRYPDRVPVDKFKPLlMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN-EMDSTCgqYWPDSDKTNFGSFT
.  |||| | .. |  .   . .   |    |||| . .    ..... ||.|   |. ||||||..    ||. |   ..|    ||| .... .|  .
dqtknrykdvgafdhtrvt.lqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsdaevcygdia

IELLSDRTLTdTMTERVLKVTTSKKK--GERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNNTSEKK--FLVVCMDGVGASPTFLAANAAIDRVRED
.    .  |    . | .||   . .   || . |..|. ||.   ||       ..|  ..  | .|.    .| |  ||| . | .| . |..... .
vrvdrnielp.nyvirgfkvfnerdttekertvlqfhyiawpdkn.vpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkle

KTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
. |||   || ||| |  .|..| .| | |. .
nkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1963-2143 4.6e-30 99.5 In-house 7-189 (297) alignment 
Range on Protein: 1963-2143
Range on HMM: 7-189/297.0
DGFEKEYKALLNKSDEGCIGNNPENKP--KNRYKNIITYDEHRVKLNKLPTEpgADYINATFIDGYKK--ENAFIASQGPNAASLNDFWQMVYEQRTSTI
   |.|. .||...  .       |    ||||..|...|. |||| . .||   ||||| ..   ..  .  .| .|||  |...|||..|.||   .|
keleaekdllldeargesfssakrnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvi

VMLTNLLEKDKKKCIEYWPSAGNHK-RYGELEVI-AREVKDEGSYVLRkFEVGKPDRtTNRLNITQYHYTIWPDMGVPESSQPLLDF
||...| |  ..||  ||||. . . . |.. |    .. ||   |    |.    | ...  ..   .  ||| |||   . |  |
vmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.telqliyr.sesrvvrhvqflswpdhGvpsdledlvrf
0051429 (Phosphotyrosine protein) phosphatases II 2307-2514 3.5e-29 97.7 In-house 2-228 (272) alignment 
Range on Protein: 2307-2514
Range on HMM: 2-228/272.0
DDNDYINASFFDVEGR---KNVHVCTQCPLMSTVGDFWRLvWDYDIHTIIHLNEMD----STCGQYWP------------DSDKTNFGSFTIELLSDRTL
. ..||||.. .  ||   ...  ....||  |. ||||| ....|.||. | . .      | .|||            .    ..| ... |||  .|
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSLVPRSKMDFFELLTQvdnnntsEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVD--------I
.|..  . | . ... .  |....|.|..|| ..  . .  ...||| .       ....|| |. |.. . |. |.   . .| ..  ||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSV
. ||..||. |||.|   | |.|.|..|... .|.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2279-2514 7.8e-29 95.5 In-house 19-267 (270) alignment 
Range on Protein: 2279-2514
Range on HMM: 19-267/270.0
VNAKKNRYPDRVPVDKFKPLLMTKgDEVDDNDYINASFFD-VEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMD----STCGQYWPDSDKT-
 ..| ||| | .|  . .  | .  .| .   |||| .   ..|.|.  .... || .|. .|||..|.   ..|. . ..     . | .||| . |. 
rgkklnRyadiLPsPatRvrleel.eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-NFGSFTIELLSDR-TLTDTMTERVLKVTtsKKKGERQITQLQYLGWPNDSLVPRSK-----MDFFELLTQVDNNNTSEKK---FLVVCMDGVGASPTFL
 ..   .|. |.   . ..    . |...  .|  ||...  .|  ||... ....       .  ..| .| . ... .|   .|| | .||| . |..
vkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

AANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQDSV
| . |.  . |.| ||. . ...||| |. .|.  |.||| | ... | . .
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_CG42327_pd Subfamily CG42327 1984-2142 9.7e-29 95.0 In-house 25-185 (319) alignment 
Range on Protein: 1984-2142
Range on HMM: 25-185/319.0
NPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKK-ENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSA---
 .  |.|.|. |..   | || |.. . ..   |..|... ||.. .| .||.| .   |  |||..|.||.. .|| ||.| |.  |.| ||.|.    
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRTTNRlNITQYHYtIWPDMGVPESSQPLLD
 |.. ||.. |  .. . .  |..  . . . |.   | ..| | |  |.. .|| . ..|. 
dntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleaevPaeeaalia
0049772 (Phosphotyrosine protein) phosphatases II 2273-2517 2.1e-28 95.4 In-house 39-286 (314) alignment 
Range on Protein: 2273-2517
Range on HMM: 39-286/314.0
QKGSLPVNAKKNRYPDRVPVDKFKPLlmtKGDEVDDNDYINASFFDVEgrkNVHVCTQCPLMSTVGDF----------WRLV--WDYDIHTIIH------
 ...|..| .||||.| .|.| .  |   .| .|.. ||||||..|     .  ..|| ||  || ||          ||.|  .|.....|        
lvadlflnrdknryldilpadnrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LNEMDSTCgQYWPDSDKTNFGsftiellsdrtltdtmtervlKVTTSKKKGERQITQLQYLGWPNdSLVPrSKMDFFELLTQVDN
               |...|     ... .|  ..                      ........ ||.. .. .. .|    .| .  || |.|  ...
adelsrLdaAlgKtpllildgng.neptaadlellk.....................eelydpelferlgikylripvpD.gsap.lledfdeflefiee

NnTSEKKFLVVCMDGVGASPTFLAANAAIDRVredkTVDIFSAVKRLRKSRP-----GVVDELERYEFCYDVLAAYQDSVQTY
.   ....|| |..|.| ..||..|   . .      |..  |....|. ||     | .  ||.|||....|  |.. ....
a.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2280-2505 4.2e-28 93.2 In-house 3-233 (237) alignment 
Range on Protein: 2280-2505
Range on HMM: 3-233/237.0
NAKKNRYPDRVPVDKFKPLLMTKGDEvddNDYINASFF-DVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE----MDSTCGQYWPDSDKT-N
|  |||| . |  |. . .|   | .    |||||... ...|  . ....| || |.  |||..||.     |. |       .  | .|||..|.   
nkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

FGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNNTS---EKKFLVVCMDGVGASPTFLAANAAIDR
.| .|. |  .  ..|     .| ..  ..|. | | | |.  ||.   ||.    .. .  .. |..        ... |  ||| .  ||  .| . .
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrg.vpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

VREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYD
 .| | |||.  |. . . || ...  ..| | ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2279-2504 2.5e-27 90.6 In-house 6-233 (239) alignment 
Range on Protein: 2279-2504
Range on HMM: 6-233/239.0
VNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFF-DVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE----MDSTCGQYWPDSDkTN
||  |||| . |  |. . .|  |  .   .||||||.. | .|  . ...||  .  . |||||..|.     |. |          | ||||||  ..
vnkaknryanivtydhsrvvl.eklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

FGSFTIELLSDRTLTDTMTeRVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNT-SEKKFLVVCMDGVGASPTFLAANAAIDRVR
.  . . |     ..| .  | . ..   .  || . | ..  || |  ||.     . |  .. ...    . ... |  ||| . .||  .| . . .
ycnlrvtlrktevfadyii.rtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

EDKTVDIFSAVKRLRKSRPGVVDELERYEFCY
..||||||  || .|. || .|.  |.| | .
kqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2279-2504 2.6e-27 90.5 In-house 7-234 (239) alignment 
Range on Protein: 2279-2504
Range on HMM: 7-234/239.0
VNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFF-DVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE----MDSTCGQYWPDSDkTN
||  |||| . |  |. . .|  |  .   .||||||.. | .|  . ...||  .  . |||||..|.     |. |          | ||||||  ..
vnkaknryanivtydhsrvvl.eklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

FGSFTIELLSDRTLTDTMTeRVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNT-SEKKFLVVCMDGVGASPTFLAANAAIDRVR
.  . . |     ..| .  | . ..   .  || . | ..  || |  ||.     . |  .. ...    . ... |  ||| . .||  .| . . .
ycnlrvtlrktevfadyii.rtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

EDKTVDIFSAVKRLRKSRPGVVDELERYEFCY
..||||||  || .|. || .|.  |.| | .
kqktvdifnyvkairedrphmvqtseqyvfih
0048076 (Phosphotyrosine protein) phosphatases II 2117-2219 1.5e-26 88.2 In-house 44-140 (145) alignment 
Range on Protein: 2117-2219
Range on HMM: 44-140/145.0
RLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADsGPIIVHCSAGVGRTGTFITINCMIEmieaeKKIDVFNFINEMRKRRAFMVQVQQQYEFIYE
  ...||.|. |||.|||.... ||.| .....| ... ||..||||||||||||.. . .|..     ....... ....|..| ..|. ..|..|.||
erlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflye

TLL
 .|
fel
0048179 (Phosphotyrosine protein) phosphatases II 2115-2216 3.8e-26 86.9 In-house 44-139 (144) alignment 
Range on Protein: 2115-2216
Range on HMM: 44-139/144.0
TNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKNANPADsGPIIVHCSAGVGRTGTFITINCMIemieaEKKIDVFNFINEMRKRRAFMVQVQQQYEFI
    ...||... |||.|||.... ||.| .....| . . ||..||||||||||||....  |.     ........ ....|.|| ..|. ..|..|.
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

YE
.|
le
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2282-2494 1.1e-25 85.0 In-house 52-264 (301) alignment 
Range on Protein: 2282-2494
Range on HMM: 52-264/301.0
KKNRYPDrVPVDKFKP-LLMTKGDEVDdndyINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN----EMDSTCGQYWPDS--DKTNF
.|.|||  || .      ....|  |     | | . . .|. .  ..|| || .|  ||| ..  ||...|. |     .. . | .| | .  .| . 
dkhrypt.vPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GSFTIELLSD-RTLTDTMTERVLKVTTS-KKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNnntSEKKFLVVCMDGVGASPTFLAANAAIDRVR
| |.|.. .    | . ...| |.|. | .|   | .|  ||  |..   ||.|... |.|.  | .   |||  .| | .|.| | .|....    .| 
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrg.vPkshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteylareve

EDKTVDIFSAVKRLRKSRPGVV
 |.|...  |.|.||. |   |
adptieltealkhlrehrwngv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2259-2499 4.5e-25 82.9 In-house 33-271 (290) alignment 
Range on Protein: 2259-2499
Range on HMM: 33-271/290.0
VLEYMAPMESTGSDQKGSLPVNA--KKNRYPDRVPVDKFKPLLMtKGdevDDNDYINASFfdVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN
 || . |   ..  ..  .  |.  ||||| | |  || . .|   |    | ||. | .  |.| | . . || .| .|| |.||.| . .. .|. | 
yleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk.dG...ydGdyvhany..vkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlc

EM----DSTCGQYWPDSD--KTNFGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDnnnTSEKKFLVV
|.     . | ||.|. .     ||..|.    . .  . .  ..| |   ..  | ..  |.   ||. | |. |.. .. .|  .    .      | 
eliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valstlallrtlrilr...kasGpvvvh

CMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELER
|  |.| . || | ..... . . | .|.   |. ||.|| . |.   .
csaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1965-2222 2.1e-24 80.5 In-house 28-285 (302) alignment 
Range on Protein: 1965-2222
Range on HMM: 28-285/302.0
FEKEYKALLNK--SDEGCIgNNPENKPKNRYKNIITYDEHRVKLNKLPtepgADYINATFIDGYKKENAFIASQGPNAASL---NDFWQMVYEQRTSTIV
 .||.|.. .   . | |     .|  ||. ...  .|...|||.. |     .|.||. ..  . ..  | .| |.  |    ..||.||....  ..|
vkkefkkidtmkvdlekCk.afkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLTNLLEKDKkKCIEYWP-SAGNHKRYGELEVIAREVKDEGSYVlRK--FEVgKPDRTTNRLNITQYHYTIWPDMGVPESSQPLLDFRDIV-KNANPADS
.|    | .|    |..|  .|..| ||.. |  | |.     .  .   ||  |.  .| . .. |. | |..  ||..   |      | ..  .||.
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEv.lPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade

GpIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWS
  ...    |.|| |.|.|    .| ....|.  . . .. .|. |. .|.  .|| ..| .|| . 
n.tvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2119-2227 2.1e-24 80.7 In-house 90-199 (440) alignment 
Range on Protein: 2119-2227
Range on HMM: 90-199/440.0
NITQYHYTIWPDMGVPESSQPLLDF-RDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYET
 . ||||  ||| |||. . |.| . .|. .. . | .||..||||||.||||  |......   .   .||.|.||| ||. |  |||. .|| |..|.
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

LLQWSHCEKV
.|.   |  .
vlegllcgdt
0036282 (Phosphotyrosine protein) phosphatases II 2309-2505 5.1e-24 80.3 In-house 2-164 (174) alignment 
Range on Protein: 2309-2505
Range on HMM: 2-164/174.0
NDYINASFFDVEGRKNVHVCTQCPLMstvgdFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDsdktnfgsftiellsdrtltdtmtervlkvttSKKK
.||||||. |.  . .  ...|.||      ||.......|.|.. |.|        | .|||.                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

GERQITQLQYLGWPNDSLVPRSKmdFFELLTQVDNNNTS--EKKFLVVCMDGVGASPTFLAANAAIDRVReDKTVDIFSAVKRLRKSRPGVVDELERYEF
 || . |..||.|| ..  . |.  ..|.. .|..   .  ... || |. ||| ..|. ||   . . .  ..||... |..||. |||.|   . |.|
lerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYD
.|.
lyy
subfamily_egg_pd Subfamily egg 1965-2219 8.2e-24 78.8 In-house 16-267 (307) alignment 
Range on Protein: 1965-2219
Range on HMM: 16-267/307.0
FEKEYKALLNKSDEGCIG--NNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLT
.|. .. | . .||  .    . .|. | | | .   |  ||||.        |.| |  ..|    | || .| |   . .|||.||....   |||||
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlt

NllEKDKKKCIEYWPSAGNHK-RY--GELEVIAREVKDEG--SYVLRKFEVGKPDRTTNRLNITQYHYTIWPDMGVPessqplldFRdIVKNANPAdSGP
    |. ..|  ||| | ..  ..  | |.. . .|...    . . |. .  .|.    |.  |. .    |.  |        .| ... .  . | |
s..rkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysp........lr.vlrklrnl.skp

IIVHCSAGVGRTGTFITINCM-IEMIE-AEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
..|..  || ...|...|.   ....     |  | . .  .|.|| . |.   .| |.|  .|
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0046846 (Phosphotyrosine protein) phosphatases II 2306-2512 9.4e-24 79.5 In-house 9-174 (176) alignment 
Range on Protein: 2306-2512
Range on HMM: 9-174/176.0
VDDNDYINASFFDVEgrknVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMD----STCGQYWPDSDKTNFgsftiellsdrtltdtmtervlkvtts
  | |||||....        ..|| || .|. ||........|.... |.|.       | .|||.  | ..                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

kkkgerqitQLQYLGWPNDSLVPRskMDFFELLTQVDNNNTSEKKFLVVCMDGVGASPTFLAANaaidRVREDKTVDIFSAVKRLRKSRP-GVVDELERY
         | ..|.||  .  .    ...||| ....  .. .. || |. |.| ..|..||      .. .| .... |....|. || |.|   | |
.........qylhlpwpDhgvpdl..elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

EFCYDVLAAYQD
.|.|...  ...
rflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 2307-2504 2.5e-23 78.1 In-house 3-154 (172) alignment 
Range on Protein: 2307-2504
Range on HMM: 3-154/172.0
DDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMdstcgqywpdsdktnfgsftiellsdrtltdtmtervlkvTTSKKKGE
...||||||. |.    .  ..|| || .|. ||||......|..|. |.|                                         .. ... |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpelle

RQITQLQYLGWPNDSLVprSKMDFFELLTQVDN--NNTSEKKFLVVCMDGVGASPTFLAANAAIdrvredKTVDIFSAVKRLRKSRPGVVDELERYEFCY
|.. |..||.||  .    .   . |.| ..|.  .. .... || |. ||| ..|. ||   .      . .... ||. .|. |||.|   . | |.|
rlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2321-2509 6.9e-23 75.7 In-house 233-436 (440) alignment 
Range on Protein: 2321-2509
Range on HMM: 233-436/440.0
GRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM-DSTCGQYWPDSDK-TNFGSFTIELLSDRTLTdTMTERVLKVttSKKKGERQITQLQYLGWP
 .||  ..|| || ||| |||||| || | ||| ||.. | ||  |||   .   || ||.       .   .  | |..    |.   .| |..   ||
skknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmn.rvkvrtlel..kykeevheirqfevqtwp

N----DSLVPRS-KMD----FFELLTQVDNNNTSEK-------KFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEF
     | .  .   ||    ... | ... . ..|.         || |. |.  |  | .    .... .| ..|.|  .. || |||  |  |  | .
twiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyll

CYDVLAA
|| .|. 
cykllth
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2027-2216 2.4e-21 70.8 In-house 2-198 (199) alignment 
Range on Protein: 2027-2216
Range on HMM: 2-198/199.0
KKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLlEKDKK-KCIEYWPSAG-NHKRYGELEVIAREVKDEGSYVLRKFEVGKPDR-TTNRLNITQY
| .  .||.| |   .. ||||||.|  .  |||. .  .|.|.     |||..     .|| | | .. .  .  |..  . . .         .|..|
kgqrryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HYTIWPDMGVPESSQ---PLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKK--IDVFNFINEMRKRRAFMVQVQQQYEFIYE
 .| | .   |. .     ..  |.. |. .     |.||||| | | || |....  .   |  |   .|.|.  . .|. |  ..   |.|.|||.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2034-2214 3e-21 70.1 In-house 95-280 (302) alignment 
Range on Protein: 2034-2214
Range on HMM: 95-280/302.0
ASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPS-AGNHKRYGELEVIAREVK-------DEGSYVLRKFEVGKPDR-TTNRLNITQYH
    |   .|. .| .. . ... .| |... |...||| ||.    |.. ..|.  | . .||       |  |..| . |.    . .  .  .   .
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

YTIWPDMGVPESSQPLLDfrdIVKNANPADSgPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFI
.. ||| | |. ... ||   |.|  .      ..||||||||||||...|   |..   .|  |. . .  .|. |   || .||  ..
fsawpdhGapkeaytald...ilkfcesykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2029-2216 3.5e-21 70.3 In-house 3-197 (198) alignment 
Range on Protein: 2029-2216
Range on HMM: 3-197/198.0
ENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLlEKDKK-KCIEYWPSAG-NHKRYGELEVIAREVKDEGSYVLRKFEVGKPDR-TTNRLNITQYHY
.  .||.| |   .| ||||||.|  .  |||. .  .|.|.     |||..     .|| | | .. .  .  |..  . . .         .|..| .
qrryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TIWPDMGVPESSQ---PLLDFRDIVKNANPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAEKK--IDVFNFINEMRKRRAFMVQVQQQYEFIYE
| | .   |. .     ..  |.. |. .     |.||||| | | || |....  .   |  |   .|.|.  . .|. |  ..   |.|.|||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1992-2217 4.9e-21 70.1 In-house 24-254 (290) alignment 
Range on Protein: 1992-2217
Range on HMM: 24-254/290.0
RYKNIITyDEHRVKLNKLPTEPGADYINATFIDgYKKENAFIASQGPNAAS-------LNDFWQMVYEQRTSTIVMLTNLLEKDKK----KCIEYWPS-A
|... .   . || |.   .    ||| | ..  . .  ..|..| | ..        ...|| |. . .   .||| .  ||...     | .| |  .
RlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv

GNHKRYGELEVIAREVKDEGSYVLRKFEVGKPDRttNRLNITQYHYTIWPDMGVPESSQPLLDFRDIVKnanpADSGPIIVHCSAGVGRTGTFITINCMI
|.. ... |.|   .   |     |. .|   |.  . . .| . .  | .. |.|... ||.  . ||    |   |.||||  |. |  .. .|.   
geelkfkgltvkCkskekeddvetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

EMIE-AEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYET
 .|   .... . . ....||.|| ... .... |.   
Qkiaetsgsvkledvlkalrkqralaitsalelafvdag
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2241-2510 5.5e-21 69.9 In-house 6-276 (307) alignment 
Range on Protein: 2241-2510
Range on HMM: 6-276/307.0
WGTIKDADGRTEMSRQFEVLEYMAPMESTGSdqkgSLPVNAKKNRYPDRVPVDKFKPLLMTKGDevdDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDF
|       | ...  .|.||  ..|   |      ..  |..|||| |   .|| . .. ..|      ||| | .. .  . .  .|.| || .|. .|
wvqrtldkgvqalvdefrvlakktpegvtve....afsantdknryqdvkcqdkgrivvkfdgl...asdyihanylgiaikpkkficaqgplentqysf

WRLVWDYDIHTIIHLNEMD----STCGQYWPDS--DKTNFGSF--T--IELLSDRTLtdTMTERVLKVTTSK---KKGERQITQLQYLGWPnDSLVPRSK
| .. . .. ..| | ..       | ||||    .|  ||.   |  .. |  ..|  .  | ...||| |    .. | |..||.  || |  ||. .
wamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakkl..apdedlinvttlkvdwaqksrtiqhlqwenwp.drgvpqin

MDFFELLTQVDNNNtseKKFLVVCMDGVGASPTFLAANAAIDRVR-EDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.   .||  |  ..      .| |  ||| | | .|     |..       |.   |. ||. |.  . .  .| . . ||  |
ltainlleavrydt...npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
PTPc_DSPc_SM00012 2409-2508 5.9e-21 70.0 In-house 2-104 (105) alignment 
Range on Protein: 2409-2508
Range on HMM: 2-104/105.0
ITQLQYLGWPNDsLVPRSKMDFFELLTQVDNNNTSE---KKFLVVCMDGVGASPTFLAANAAIDRVRED-KTVDIFSAVKRLRKSRPGVVDELERYEFCY
.....|.|||.   ||..  ...||| .|..|.. .   |  .|.| .||| . || |.  .......  |.||||  ||.|||.|||.|...| | |.|
vkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DVLA
..|.
rall
subfamily_ptpA1_pd Subfamily ptpA1 2256-2466 1.9e-20 68.0 In-house 26-251 (418) alignment 
Range on Protein: 2256-2466
Range on HMM: 26-251/418.0
QFEVL-EYMAPMESTGSDQKgslpVNAKKNRYPDRVPVDKFKPLLmTKGDEVDDNDYINASFFDVEGRKNvHVCTQCPLMSTVGDFWRLVWDYDIHTIIH
.| .| | . | |..  |.|     |. |||| . .||.. .  |  | .. . .||||| . |    |.  .||| ||  |. ||||.||.   . |. 
efrlleesvgpsetsegdkk....hntsknrytnilpvnhtrvql.kkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivm

LNEMD----STCGQYWPDS-----------DKTNFGSFTIELLSdrTLTDTMTERVLKVTTSKKKGE-RQITQLQYLGWPNDSlVPRSKMDFFELLTQVD
|.         | .|||.             .  ||....||.    . |   | . .      .|| |.||| || |||.   .|     | .||  . 
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelve..viqdpereiitrnirltfegetrditqyqyegwpdhn.ipdhtqpfrqllhsit

NNN-----TSEK--KFLVVCMDGVGASPTFLAANA
| .     .|..    .| |  ||| . || .|  
nrqnqiipssdrnvpiivhcsagvgrtgtfctavi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1981-2084 2.2e-20 67.7 In-house 41-158 (350) alignment 
Range on Protein: 1981-2084
Range on HMM: 41-158/350.0
IGNNPENKPKNRYKNIITYDEHRVKLNKLP--------TEPGADYINATFIDGY----KKENAF--IASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLE
. .  |   |||||||. |.  ||||.| .        .  . ||||| ..       . .  |  || |.|    ..||......     |..||.. |
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

KDKKKCIEYWPSAGNHKR
 . .|| .||.  . .. 
lnlekcyrYWqegsyddi
0049260 (Phosphotyrosine protein) phosphatases II 2321-2505 2.6e-20 68.1 In-house 6-144 (152) alignment 
Range on Protein: 2321-2505
Range on HMM: 6-144/152.0
GRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDST----CGQYWpdsdktnfgsftiellsdrtltdtmtervlkvttskkkgerqitQLQYLG
....  ..|| |.  |. ||||......|.||. |.| .      | ||.                                            | ..| 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlp

WPNDSlVPRSKMDFFELLTQVDN-NNTSEKKFLVVCMDGVGASPTFLAANAAIdrvredKTVDIFSAVKRLRKSRPGVVDELERYEFCYD
|| .. || . . . .||  ..  .  .... || |. ||| ..|. ||   .      . |... ||...|. |||.|   . ..|.|.
wpDhg.vpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2042-2220 7.7e-20 66.0 In-house 40-219 (255) alignment 
Range on Protein: 2042-2220
Range on HMM: 40-219/255.0
SLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHK-RYGELEVIAREvkDEGSYVLRKFEVGKPDR-TTNRLNITQYHYTIWPDMGVPESSQP
... |.|..  ..|...|||... |....|| .|.|   . | .. ...|.. .       |||  |.        .  ... |.|. |..   || .. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLDFRDIVKnanpaDSGPIIVHCSAGVGRTGTFITINCMIE-MIEA-----EKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQ
.|    .|.     || ...||||.|.||. .|. .. .   || .       ..|  ....|.|..|.  ..   |  |   ..|.
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2280-2432 8.7e-19 62.5 In-house 33-188 (297) alignment 
Range on Protein: 2280-2432
Range on HMM: 33-188/297.0
NAKKNRYPDRVPVDKFKPLLMTKgdeVDDNDYINASF--FDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPDSDKT-
  .|||| | . .|. .  |.     . ..||||| .  |  |  .  ....| || .|| |||.||.. |. .|. . ..     . |  |||....  
slrknryrdilatddtrvkllrv...iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

-NFGSFTIELLSDRTlTDTMTERVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFE
 . |.. .| ||. .  .  .  . ...   .. .|...  |.|.|| |  ||    |   
lkagdvvveflssts.defdrviltelqliyrsesrvvrhvqflswp.dhGvpsdledlvr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2279-2510 1.1e-18 62.2 In-house 34-269 (285) alignment 
Range on Protein: 2279-2510
Range on HMM: 34-269/285.0
VNAKKNRYPDRVPVDKFKPLLMTkgdevDDNDYINASFFDVEGRK-NVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPDS--DK
 |   ||| |   ... . .|        | ||| ||.. . |.  . .. || ||  |. |||.....  |  .. |  .       |  |.|.   . 
anpdlnryadvrcieetrvvlkn.....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

TNFGSFTIELL--SDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSLVPRSKMDFFELLTQVDNNNTSEKKFLVVCMDGVGASPTFLAANAAID
 .|| . | |    . ... |. . .  . |     |    .   . |  | | |     . ||   | . |  ||   | |  ||| . ||.  . |  
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

RVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
|. |.  ....  |. .|  |   |.   .. | | ||  |
rimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_egg_pd Subfamily egg 2252-2513 8.8e-18 59.0 In-house 15-273 (307) alignment 
Range on Protein: 2252-2513
Range on HMM: 15-273/307.0
EMSRQFEVLEYMAPMESTgsdQKGSLPVNAKKNRYpDRVPVDKFKPLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHT
|. |..|||| ..  .|    ..     | .| |   ||.  ..  . .        .|.| |   . .   |  ...| ||  || ||||.|.  ... 
elerrlevleesvdeisl...ttaasdnnlekars.krvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqy

IIHLNEMD--STCGQYWPDS--DKTNF--GSFTIELLSDRTLTDTMT-ERVLKVtTSKKKGERQITQLQYlGWPNDSlvprSKMDFFELLTQVDNnntSE
|. |.       |  ||| .  |   .  ||. || |     .| .     ||.    .. || .   |.  . | |         ...| .. |     
ivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnss....dvysplrvlrklrn...ls

KKFLVVCMDGVGASPTFLAANAAIDRV-REDKT-VDIFSAVKRLRKSRPGVVDELERYEFCYDVLAA-YQDS
|  .| ...||  . |..|.. |.  . |   |   .  ||. ||. |.  |.   .| | | ...  ..| 
kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2281-2507 2.2e-17 58.0 In-house 44-267 (288) alignment 
Range on Protein: 2281-2507
Range on HMM: 44-267/288.0
AKKNRYPDRVPVDKFKpLLMTkgdevDDND-YINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPD--SDKTN
. ..|| .    |  . . ..     || | ||.|  .  .  |.  .|.|.|| .|.. .|... . |.. |. |.|.         .|.|    .|. 
ptrdryenlprcditr.vkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGSFTIELLSDRtltdTMTERVLKVTTSKK---KGERQ-ITQLQYLGWPNDSlVPRSKMDFFELLTQVdnnNTSEKKFLVVCMDGVGASPTFLAANAAID
.| .      .|    .  ....||.. .      |.. . .| .| |..|. || . . .. ||. .   .. .|  .| .  ||| . |.     |..
igrlctvvkkkr....adidklvkvsllriskegeekvivkilhlleWdddg.vPenylsplrllevl...kslqkPivvhssaGvGrtgtlililiale

RVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
 .| |  . | | ...||..|   .    .| . . ..
slrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2277-2510 3e-17 57.2 In-house 34-268 (281) alignment 
Range on Protein: 2277-2510
Range on HMM: 34-268/281.0
LPVNAKKNRYPDRVPVDKFKPLLMTKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDSDKT
 ||| ||||| .   .|  .  |  |  . .  ||| | .      |  .. || |   |  ||||..|. .  .|. | ..       | .|.|   . 
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

--NFGSFTIELlSDRTLTDTMTERVLKVttSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEkkfLVVCMDGVGASPTFLAANAAIDR
  .|  ....   | |.  ..    |..  | .   | ||.  .  || |  || |   ....| ..    |     .. |  ||| | |..| . |.. 
clqfdklsvsy.edstvnkslvttrlnl..syegetrlithwlwkewp.dwqvpessevmlkilrkirarstpp...vihcsagvgrsgtlmaveialqs

VREDKTV-DIFSAVKRLRK-SRPGVVDELERYEFCYDVLAAY
..   |. ||   | .||   |   |. |..| . . ||  .
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2118-2222 8.5e-17 55.9 In-house 215-344 (350) alignment 
Range on Protein: 2118-2222
Range on HMM: 215-344/350.0
LNITQYHYTIWPDMG---VPESSQPLLD-FRDIVKN------ANPADSGPIIVHCSAGVGRTGTFITINCMIE------MI-EAEKKIDV--------FN
. . | ..  |.|..    |||  . |.   |.. .       . | | ||.||||||||||||..|.. ...      .. .  .|.||        . 
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

FINEMRKRRAFMVQVQQQYEFIYETLLQWS
 .||.||.|  |||  .|. ||||.|| . 
ivnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2307-2510 9.4e-17 55.4 In-house 73-284 (302) alignment 
Range on Protein: 2307-2510
Range on HMM: 73-284/302.0
DDNDYINASFFDVEGRKNVHVCTQCPLMSTV---GDFWRLVWDYDIHTI---IHLNEMDSTCGQYWP--DSDKTNFGSFTIELLSDRTLTDTMTERVLKV
  ..|.|||  .|   ..  . .| | ....    .|||.|..  | ..   .  .|.. |  ...|    | ...|.. .         .. |. |. |
epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEv

TtSKKKGERQITQLQYLGWPNDSLVPRSKMDFFELLTQV-DNNNTSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDEL
   .   .  ..... |   ... || .  .  .  ..| ...  .... ..| . |.|   .||.. .|.... ..| . |   || .|. || .|| |
l.PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl

ERYEFCYDVLAAY
. | . | .|. |
kQyvslyiallly
subfamily_hpo-7_pd Subfamily hpo-7 2042-2219 1.1e-16 55.6 In-house 46-224 (263) alignment 
Range on Protein: 2042-2219
Range on HMM: 46-224/263.0
SLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHK-RYGELEVIAREVKDegSYVLRKFEVGK-PDRTTNRLNITQYHYTIWPDMGVPESSQP
 .. |.|..  ..|...|||..  |....|| .|.|   . | .. ...| . .|..    .|.  |. .  ..  .  ....| |. |..   || .. 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLDFRDIVKNanpadSGPIIVHCSAGVGRTGTFITINCMIE-MIEA-----EKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
 |   ....|     | ...||||.|.||.  |  .. .   || .       ..|  ....|.|..|.  ..   |  |   ..|
ilnilkvarn.....skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2275-2376 1.1e-16 55.2 In-house 40-152 (392) alignment 
Range on Protein: 2275-2376
Range on HMM: 40-152/392.0
GSLPVNAKKNRYPDRVPVDKFKPLLMTkGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE--------MDSTCGQY-
.  ..| ||||| . .| |. .  |    |.. |.||.|||...    .. ....| | .... ||||.|.. .. ||. ...         . |. |. 
aqkeinlkknryknilpydsarvklev.iddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfh

---WPDSDKTNFGS
   |||.|  .. |
ftewPdkdvpkhts
subfamily_CG42327_pd Subfamily CG42327 2153-2222 1.2e-16 55.3 In-house 245-315 (319) alignment 
Range on Protein: 2153-2222
Range on HMM: 245-315/319.0
ADSGPIIVHCSAGVGRTGTFITINCMIEMIEAE-KKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWS
 . ||..|||| ||||||. |. .  |. .|   . .|. . .  .|. ||  |. ..|||||| .| ...
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
0051082 (Phosphotyrosine protein) phosphatases II 2310-2506 1.5e-16 55.8 In-house 4-148 (151) alignment 
Range on Protein: 2310-2506
Range on HMM: 4-148/151.0
DYINASFFDveGRknvHVCTQCPlmstVGDFWRLVWDYDIHTIIHLNE---MDsTCGQYWPDSDktnfgsftiellsdrtltdtmtervlkvttskkkge
||||.|. .  |.     ....|      ||..|.....| ||. |..   .. .| .|.|. .                                    
dyinfsyvt..gg...lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg....................................

RQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNnnTSEKKFLVVCMDGVGASPTFLAANAAIDRvredktVDIFSAVKRLRKSRPGVVDELERYEFCYDV
........|.||. . .| |   . |.| ....  ......|| |. |.| . |. |.   . .      |....|.. .|..|||||   . . |.. .
ievlhipildwpdpg.lplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2159-2219 1.6e-16 54.4 In-house 2-62 (69) alignment 
Range on Protein: 2159-2219
Range on HMM: 2-62/69.0
IVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
.||||.| |||||||.|   .  | .|| .|.|| .. ||| |  ||  ...| ||...| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2275-2510 1.7e-16 54.8 In-house 50-288 (305) alignment 
Range on Protein: 2275-2510
Range on HMM: 50-288/305.0
GSLPVNAKKNRYPDrVPVDKFKPLLMTKGDevdDNDYINASFFDVEGR-KNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN---EM-DSTCGQYWPDS
 |  ..  |||| | ||..  . ... |       ||| | .  .    ..  .|.| ||  |. .|| .| .  .  |. |    |.    | |||| .
qsadiaitknryqd.vpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

--DK-TNFGSFTIELLSDRTLTDTMTERVLKVTTSKKKG--ERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDnnnTSEKKFLVVCMDGVGASPTFLAA
  .| .  .   .| .|     .  .|  . .      |  .  . .||.  || |  ||  |.  .|||. .     |.   .| |  |.| . | .| 
qgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewp.drgvppckltslellsair...gskvpivvhcsagigrtgtivai

NAAIDRVREDKTVD-IFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
.  .... |.| .  .   || ||  |   ...  .| | . |.  |
eyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2325-2506 1.9e-16 54.8 In-house 6-199 (199) alignment 
Range on Protein: 2325-2506
Range on HMM: 6-199/199.0
VHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDSTC----GQYWPDS--DKTNFGSFTIELLSDRTLTD-TMTERVLKVTTSKKKGERQITQLQYLGW
 ...|| ||  |. |||..||.     |. .|. .         ||| .    ...||...   .  |  | |.|  .|   |.     |.|.. |.  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PNDSlVPRSK--MDFFELLTQVDNNNTSEKK--FLVVCMDGVGASPTFLAANAAIDRVREDKT--VDIFSAVKRLRKSRPGVVDELERYEFCYDV
 . .  |     . |     .| ..   ||    .| | || | .  |.| .  .    | ||  ||.|   ||||..| |..  |. |.| |.|
kekt.tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2159-2219 2e-16 54.1 In-house 1-61 (69) alignment 
Range on Protein: 2159-2219
Range on HMM: 1-61/69.0
IVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
.||||.| |||||||.|   .  | .|| .|.|| .. ||| |  ||  . .| ||...| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2325-2506 2e-16 54.8 In-house 5-198 (198) alignment 
Range on Protein: 2325-2506
Range on HMM: 5-198/198.0
VHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDSTC----GQYWPDS--DKTNFGSFTIELLSDRTLTD-TMTERVLKVTTSKKKGERQITQLQYLGW
 ...|| ||  |. |||..||.     |. .|. .         ||| .    ...||...   .  |  | |.|  .|   |.     |.|.. |.  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PNDSlVPRSK--MDFFELLTQVDNNNTSEKK--FLVVCMDGVGASPTFLAANAAIDRVREDKT--VDIFSAVKRLRKSRPGVVDELERYEFCYDV
 . .  |     . |     .| ..   ||    .| | || | .  |.| .  .    | ||  ||.|   ||||..| |..  |. |.| |.|
kekt.tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_CG42327_pd Subfamily CG42327 2277-2440 4e-16 53.6 In-house 24-193 (319) alignment 
Range on Protein: 2277-2440
Range on HMM: 24-193/319.0
LPVNA-KKNRYPDRVPVDKFKPLLMTKGDEvDDNDYINASFFD-VEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN---EMD-STCGQYWPDSD
.|| . .|.|. . ||. . .. |  .||. | . |..||.    .  .| ....| .| ..  ||||.||.    .|. |    |     | .|.| ..
vPvtskdksrvinvvPlPetrvvlqrigdd.dkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

K----TNFGSFTIELlSDRTLTDTMTERVLKVTTSKKKGERQITQLQYlGWPnDSLVPRSKMDFFELLTQVDNN
       .| . . |  .|   |      | .   .|.  |..|   |  |. .. || ..  .. .| .| . 
tldntslyGdilvtl.kgrevkdryaistlllkrvdkeesrelthywy.kwl.eaevPaeeaaliamllevrss
subfamily_eak_pd Subfamily eak 1986-2150 7e-16 52.5 In-house 51-210 (332) alignment 
Range on Protein: 1986-2150
Range on HMM: 51-210/332.0
ENKPKNrYKNIITYDEHRVKLNKLPTEPgADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAG-NHKR
|.  .|   .|. || . |.|     ..   ||||. ..  .  . .| .  ..   .  |||||.||.. .||.| . .|.. .|   |.|  . .  .
eavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGELEVIAREVKDEGSYVLRKFEVGKPDRTTNrlnITQYHYTIWPDMGVPESsQPLLDFRDIVKNA
.| |.|  .|   .. .  |..|. | . | .   .  |..  | .. .|   . .| .|...|..
fGildverkefvkrniletrllelskGnethr...vlhykvfGwtettlpky.edflalrkvmkev
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1944-2037 1.5e-15 51.2 In-house 3-95 (95) alignment 
Range on Protein: 1944-2037
Range on HMM: 3-95/95.0
EPIHISNL-AKVIKAKRMSRDGFEKEYKALLNKSDE-GCIGNNPENKPKNRYKNIITYDEHRVKLNklpTEPGADYINATFIDGYKKENAFIASQG
 |||.| . ..|.. .  | . |..|.|..   |     .|    | ||||. ||. ||  || |    |   .||||| |.||| . |..||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1987-2219 1.5e-15 51.6 In-house 47-276 (303) alignment 
Range on Protein: 1987-2219
Range on HMM: 47-276/303.0
NKPKNRYKNIITYDEHRVKLNKlptepgADYINATFIDGYKKENAfIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKCIEYWPSAGNHKRYG
|  |||. ..|  |  .|||        . || |....   . .| | .| | . .  |||||. ||.   ...|    | ||      .|   .  .. 
nmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

ELEVIAREVKD---EGSYVLRKFEVGKPDRTTnrlNITQYHYTIWPDMGVPESSQPLL-----DFRDIVKnaNPADSGPIIVHCSAGVGRTGTFITINCM
|  .   | |       .||.   | . |  .    .  .||  ||   .|  . | .     . . ...  . .|| | .    .|.||.|||  ..  
ersirvgefkrvelgdgwvlkvlsvsngdyks...flhvhhykawphnsipsdgspkfvkqiwqlqsvlr..kysdstptvymslsgcgragtfalfeta

I-EMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLL
   . . .  .|. . .. .|. |   ||   |. ..|  | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2390-2511 1.9e-15 51.2 In-house 262-385 (392) alignment 
Range on Protein: 2390-2511
Range on HMM: 262-385/392.0
TMTERVLKVTTSKKkGERQITQLQYLGWPNDS----LVPRSKMdffELLTQVDN--NNTSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAV
 .. . ||.. | |     .|| |. |||       .  || .    |.  | .  |.. |   || |. | | .  | .|   | .. | ..|||| .|
dvrskqlkefrslk.ashtvtqyqfhgwpkhgsdqqsgarsll...kliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtv

KRLRKSRPGVVDELERYEFCYDVLAAYQ
| ||  |  .|.  | | | |||   | 
kilradrmqfvqteeeyafvydvireyl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2151-2222 3.7e-15 50.1 In-house 261-344 (349) alignment 
Range on Protein: 2151-2222
Range on HMM: 261-344/349.0
NPADSGPIIVHCSAGVGRTGTFITINCMIEMIEAE----KKIDVF--------NFINEMRKRRAFMVQVQQQYEFIYETLLQWS
. ... ...|||||| ||||...|.. .....|       ||..           .||.|| |  |||  .|. .|||.||.. 
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
0044763 (Phosphotyrosine protein) phosphatases II 2307-2507 1e-14 50.1 In-house 16-167 (178) alignment 
Range on Protein: 2307-2507
Range on HMM: 16-167/178.0
DDNDYINASFFDvegrKNVHVCTQCPlmstvGDFWRLVWDYDIHTIIHLNEMDSTC----GQYWPDSDKtnfgsftiellsdrtltdtmtervlkvttsk
   ||||||. .     .. .... |      |...|.....|..|. |.| .        .|||..                                 
ersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

kkgerqitqLQYLGWPN-DSLVPRSKMDFFELLTQVDNNN-TSEKKFLVVCMDGVGASPTFLAANAAIDRvredkTVDIFSAVKRLRKSRPgVVDELERY
         .||| .|  |. || .   |.|..  ...   ..... || |. ||| |.|. ||   . .      .....|....|. || .|   . .
.........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgql

EFCYDVL
...|.. 
rqLyefe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2278-2426 2.1e-14 47.8 In-house 94-239 (244) alignment 
Range on Protein: 2278-2426
Range on HMM: 94-239/244.0
PVNAKKNRYPDRVPVDkFKPLLMTKGDEvdDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDSTcGQYWPDSDKTNFGSF
| |. |||    .|.| |. . ..||     | ||||||    ||   .. || ||  |  |||... .  .  .. |  ..    .|||||.  ..   
pnnswknregaglpfd.fnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.deywpdseplewyee

TIE-LLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSLVPRS
 |   |.||     .    |.. .  ..  . .| .|   || |   |  
ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpnd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2274-2509 6.9e-13 42.9 In-house 41-277 (303) alignment 
Range on Protein: 2274-2509
Range on HMM: 41-277/303.0
KGSLPVNAKKNRYPDRVPVDKFKPllmtkgdEVDDNDYINASFFDVEGRKNVhVCTQCPLMSTVGDFWRLVWDYDIHTIIHL---NEMDSTCGQY-WP-D
|  .  | .|||. | . .|. |        .. |  || ||. ... .|.  . || ||  |  |||... .  .. .. |   .|.|.  |.. .| .
knqfvknmdknrfvdvicldhskv.......klsdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

SDKTNFGSFTIELLSdRTLTDTMTERVLKVTTS-KKKGERQITQLQYLGWPNDSLVPRSKMDFFELLTQVDN---NNTSEKKFLVVCMDGVGASPTFL-A
 |  .|   .| .       . .   |||| .  . .    .   .|  || .|.   .   |   . |..    . .  .  . . . |.| . ||   
qdflkfeersirvge.fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf

ANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAA
  | .    |. ..|.   .. .|. |   |..| .. . | .|| 
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2284-2510 9.1e-13 42.6 In-house 47-275 (312) alignment 
Range on Protein: 2284-2510
Range on HMM: 47-275/312.0
NRYPDRVPVDKFKPLLmtKGdevDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN----EMDSTCGQYWPD-------SDKT
||||.    |. .  |   |   |.| || | |  .  . .  |||| || .|.  ||.|.      .|| |     .    | .|  |        |. 
nrypniqcwdrgrftl..ag...denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

NFGSFTIELLSDRTLTDTMTERVLKVTTSKKKGERQITQLQYLGWPNDSlVPRSKMDFFELLTQVDNNntsEKKFLVVCMDGVGASPTFLAANAAIDRVR
 .  .  |.       | .| |||||       | .. . |.  ||.   .| |    . ||. | ..    |  .  |  ||| . |.   .. |  .|
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhg.mpdscdtalrllsavkkd...kkpviahcsagvgrtgtlaliesmiaalr

EDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAY
  .  ..  .   ||| |   |  . .| ..  ..  .
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2155-2220 1.6e-12 41.9 In-house 228-293 (297) alignment 
Range on Protein: 2155-2220
Range on HMM: 228-293/297.0
SGPIIVHCSAGVGRTGTFITINCMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQ
. ...|||||||||.|  .  . .....  ..  ||  ... .|..|| .||  .|.|..|.  |.
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2305-2424 2.9e-12 41.0 In-house 9-128 (130) alignment 
Range on Protein: 2305-2424
Range on HMM: 9-128/130.0
EVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDSTcGQYWPDSDKTNF-GSFTIELLSDRTLTDTMTERVLKVTTSKK
 ...|.||||||  . || . .. || ||  |  |||... .  .  .. |  ..    .|||||.  ..     |  |.||   . .    |..    .
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.deywpdsePlewyeediivtltdrdefknikasnleiesdln

KGERQITQLQYLGWPNDSLVP
.  . .| .|   || |   |
eshqaltmfqisnwpsdgttp
0048076 (Phosphotyrosine protein) phosphatases II 2394-2508 4.4e-12 41.4 In-house 32-140 (145) alignment 
Range on Protein: 2394-2508
Range on HMM: 32-140/145.0
RVLKVTTSKKKGERQITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEKKFLVVCMDGVGASPTFLAANAAIDrvredKTVDIFSAVKRLRKSRPGV
.|| .|. ..  ||...|..||.|| |  || .  .. |.| ....   .... || |. ||| ..|. ||   .      . |....|....|. |||.
tvlnltselellerlgiqylylpwp.DhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga

VDELERYEFCYDVLA
|   . ..|.|... 
vpnpgqlrflyefel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2024-2090 7.7e-12 39.3 In-house 230-293 (440) alignment 
Range on Protein: 2024-2090
Range on HMM: 230-293/440.0
DGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLlekDKKKCIEYWPSAGNHKRYGELEV
.|| | |||||.| |  ... |||..|.. | |||.|| .|   . | |  |||       .| . |
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2329-2504 1e-11 39.5 In-house 65-252 (290) alignment 
Range on Protein: 2329-2504
Range on HMM: 65-252/290.0
TQCPL-------MSTVGDFWRLVWDYDIHTIIHLNEMDS--------TCGQYWPDSDK--TNFGSFTIELlSDRTLTDTMTERVLKVTTSKKKgERQITQ
|| |.        ||. .|| .. .  .. .. | |..         .| .| |.|     .|. .|..   ..   | . .| | |.  ... | ..| 
tqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddvetRelvvkfddee.eftvtH

LQYLGWpNDSLVPRSKMDFFELLTQVDNNNTSekkFLVVCMDGVGASPTFLAANAAIDRVR-EDKTVDIFSAVKRLRKSRPGVVDELERYEFCY
 .. || |.. |....  . .|. .| ...|     .| |.||.  | .. | . .   .    . | . ...| ||| |  .. . . . |  
sllkgW.nklnvqedtktllsliqkvkasktp...vivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1984-2097 1.3e-11 38.6 In-house 93-199 (244) alignment 
Range on Protein: 1984-2097
Range on HMM: 93-199/244.0
NPENKPKNRYKNIITYDEHRVKLNKlpTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDkkkciEYWPSAGNHK
||.|  |||    . .|  || |.|     |  ||||.|.    .   .| .| | | .  |||.|. |.    .|.|  . |.|     |||| .   .
npnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdseple

RYGELEVIAREVKD
 | |   ..   .|
wyeeditvtltdrd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1944-2025 3.8e-11 37.0 In-house 4-85 (440) alignment 
Range on Protein: 1944-2025
Range on HMM: 4-85/440.0
EPIHISNLAKVIKAKRMSRdGFEKEYKALLN-KSDEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPGADYINATFIDG
 || ....|  .. .| ||  || |.  | .  |. . | . |.|| ||||.||..||  || |...   | .|||||..|.|
rpiivadfadyvqnnrrsr.afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2280-2490 6.2e-11 36.4 In-house 52-269 (310) alignment 
Range on Protein: 2280-2490
Range on HMM: 52-269/310.0
NAKKNRYPDRVPVDKFKPLLmtKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLN----EMDSTCGQYWPDSDKTN-F
. .|||| | |  |. .  |  | |    .||| | .   .  ..  .|.| ||  |. ||||....    .|. |     |    |  |||    |. .
ymhknrysdvvcldtsrvkl..kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GSFTIELLSDRTLTDTMTERVLKV-----TTSKKKGERQITQLQYLGWPN--DSLVPRSKMDFF--ELLTQVDNNntsekKFLVVCMDGVGASPTFLAAN
|   .  ||. .    . .  .          ..  . .  ... . |||  |  ||  |       ||.||          .| |  |..   . .| .
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg.....pcvvhcsagkdrlyvvvalk

AAIDRVREDKTVDIFSAVKRLRKSR
 .||.... . ||.   .  |.|||
lkidkldrglkvdaeevktellksr
0048179 (Phosphotyrosine protein) phosphatases II 2387-2505 6.4e-11 37.7 In-house 48-139 (144) alignment 
Range on Protein: 2387-2505
Range on HMM: 48-139/144.0
LtdtmtervlkvttskkkgerqITQLQYLGWPnDSLVPRSKMDFFELLTQVDNNNTSEKKFLVVCMDGVGASPTFLAANAAIdrvrEDKtVDIFSAVKRL
                      ..|...|.|| |  || .  .. |.|  ...   .... || |. ||| ..|. ||   .    . . .....|....
e.....................giqylhlpwp.DhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalv

RKSRPGVVDELERYEFCYD
|. |||.|   . ..|...
rsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1987-2072 1.1e-10 35.6 In-house 34-118 (332) alignment 
Range on Protein: 1987-2072
Range on HMM: 34-118/332.0
NKPKNRYKNIITYDEHRVKLNklPTEPGADYINATFIDGYKKENAFIASQGPN-AASLNDFWQMVYEQRTSTIVMLTNLLEKDKKKC
|   ||   .  .|  ||.|   | .   |. ||...||| |..|.| .| |    .   ||.|| |.. | |... .. ||.|.|.
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
fn3 Fibronectin type III domain 1768-1847 1.3e-10 34.5 Pfam-A 9-85 (85) alignment 
Range on Protein: 1768-1847
Range on HMM: 9-85/85.0
TAKNDTSISIEWPLVDdtdLGMYRITHYTVSYSSGTADGdtIDVTYITSPMV--CTIAPLEPGTEYYIKVRAVNEGGPGGWS
.. ..||....|   .    |   ||.|.| |.. .  .   .... ...    .|.  |.||||| ..|.|||..| |..|
sevtstsltlsWsppk...dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2282-2402 2.3e-10 34.8 In-house 49-183 (350) alignment 
Range on Protein: 2282-2402
Range on HMM: 49-183/350.0
KKNRYPDRVPVDKFKPLLM-------TKGDEVDDNDYINASFFDVE---GRKNV---HVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQ
 |||| . .| .. .  |        .|   .  ||||||..  ..    . |    .. || || ||| ||....   ... |. |.. .      | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDsdkTNFGSFTIELLSDRTLTDTMTERVLKVTTSK
||..    ..  .|. | | .  .  . . .| ..  |
YWqe...gsydditvklaskwenimgindsslysadvk
0038934 (Phosphotyrosine protein) phosphatases II 2122-2215 3.7e-10 35.2 In-house 81-170 (194) alignment 
Range on Protein: 2122-2215
Range on HMM: 81-170/194.0
QYHYTIWPDMGVPESSQPLLDFRDIVKNANPAD-SGPIIVHCSAGVGRTGTFITINCMIEmieaeKKIDVFNFINEMRKRRAFMVQVQQQYEFIY
.|.  ..|| |.. | . ||.| |.|.  . .| .| . ||| ||.|||||..    .        ....   |. .| .|  ... |...| ..
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleall
subfamily_PTPDC1_pd Subfamily PTPDC1 2118-2217 4.1e-10 34.4 In-house 81-171 (182) alignment 
Range on Protein: 2118-2217
Range on HMM: 81-171/182.0
LNITQYHYTiWPDMGVPeSSQPLLDFRDIVKNAnpADSGPIIVHCSAGVGRTGTFITINCMIemieaEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYET
 .|. | .. |.| ||. | . .||   .|. |   . | . ||| || ||||  |.   .       |...  . |. .|..|.  .| ..| |.. | 
qgiyvynfg.wkDygva.sleriLdivkvvafa..lqegkvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqvelvkef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1977-2078 4.3e-10 33.4 In-house 38-155 (349) alignment 
Range on Protein: 1977-2078
Range on HMM: 38-155/349.0
DEGCIGNNPENKPKNRYKNIITYDEHRVKLNKLPTEPG--------------ADYINATFID--GYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVM
|.  . .  |   |||||.|. |.  ||||.| .  .                ||||| ..    .. |. .|| | |  ....||....  ..   .. 
ddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvls

LTNLLEKDKKKCIEYWPS
|..  |.. .||  ||  
Lnddkelslekcdiywqe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2280-2511 5.2e-10 33.5 In-house 48-287 (305) alignment 
Range on Protein: 2280-2511
Range on HMM: 48-287/305.0
NAKKNRYPDRVPVDKFKPLLmtkgDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEM----DSTCGQYWPDSDKTN--
.|.|||| |   .|. .  |    .     .|| | .       .  .||| ||  |  ||| . ..  ...|. | ..       | .|..  ||    
eagknrykdvgcldnnrvkl....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FG----SFTIELLSDRTLT------DTMTERVLKVTTSKKKgERQITQLQYLGWPnDSLVPRSKMDFFELLTqvdNNNTSEKKFLVVCMDGVGASPTFLA
|       .. . |  ||        ..|| || .  . .|  |..|.  .  || |  || . .  .|||.   .  .|     | |  |.| . . . 
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwp.drgvpaadlailelle...karpskgpivvhcsagigrtgsvvm

ANAAIDRVREDKTVDIF-SAVKRLRKSRPGVVDELERYEFCYDVLAAYQ
 .  .|.. . . ..     ....|. |   ..  ..| | ..|.  | 
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
fn3 Fibronectin type III domain 1675-1746 5.9e-10 32.3 Pfam-A 8-84 (85) alignment 
Range on Protein: 1675-1746
Range on HMM: 8-84/85.0
VDSTNQTYTIIAWEKPELINGLFFRYDI--QKDNDN---IIMIVEEEERIYSFSDLEPNKEYTIQVRAVSNGGNGAW
|.... |.  . |..|.  .| . .|..  ......       |.. .. . ...|.|..||...|.||...|.| .
vsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2322-2496 1.3e-09 32.0 In-house 89-273 (302) alignment 
Range on Protein: 2322-2496
Range on HMM: 89-273/302.0
RKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE----MDSTCGQYWPDS--DKTNFGSFTIELLSDRT----LTDTMTERVLKV--TTSKKK--GER
...|      |  ||.  .| |. .|..  .. | .     .  | .|. |   .. .|| .|.. .| .|    .||  . .. .|  . .|||   ..
kekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkk

QITQLQYLGWPNDSlVPRSKMDFFELLTQVDnnnTSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDE
 .  |.. .||.    |.     ...|   .   .  |. || |  ||| . |..|    |.   ..|. |. | |. .|. | | | .
tvdilafsawpdhG.apkeaytaldilkfce...sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd
subfamily_eak_pd Subfamily eak 2152-2222 1.8e-09 31.4 In-house 234-305 (332) alignment 
Range on Protein: 2152-2222
Range on HMM: 234-305/332.0
PADSGPIIvHCSAGVGRTGTFITINCMIEMIEAEKK--IDVFNFINEMRKRRAFMVQVQQQYEFIYETLLQWS
|    |||  .. |  |.|.|. |. .|..|.. ||    | ..|  ....|   | |..|. |||| .|.. 
ppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2449-2508 1.9e-09 31.7 In-house 2-61 (69) alignment 
Range on Protein: 2449-2508
Range on HMM: 2-61/69.0
VVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLA
| |  | | . ||.|    . |.. .| ||||  |. .|| || .| . . | | .| |.
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2448-2508 2.5e-09 31.4 In-house 2-62 (69) alignment 
Range on Protein: 2448-2508
Range on HMM: 2-62/69.0
LVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLA
.| |  | | . ||.|    . |.. .| ||||  |. .|| || .| .   | | .| |.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_CG42327_pd Subfamily CG42327 2447-2512 3.1e-09 30.9 In-house 250-316 (319) alignment 
Range on Protein: 2447-2512
Range on HMM: 250-316/319.0
FLVVCMDGVGASPTFLAANAAIDRVRED-KTVDIFSAVKRLRKSRPGVVDELERYEFCYDVLAAYQD
  | | |||| . . .|.. || .. |  ..|||   |  .|. |   | . |.||| | ||  |  
lvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2323-2495 7.6e-09 30.0 In-house 34-205 (255) alignment 
Range on Protein: 2323-2495
Range on HMM: 34-205/255.0
KNVHVCtqcplmsTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDS--DKTNFGSFTIELLSdrTLTDTM-TERVLKVTTSKKKGERQITQLQYL
||...        ||  |.. .   . .... | ..       | .|.|    .|  .   ..      . .| .   ...  | ..||  ....  .| 
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysyk

GWPNDsLVPRSKMDFFELLTQVDNnntSeKKFLVVCMDGVGASPTFLAANAAID----RVREDKTVDI--FSAVKRLRKSRPGVVD
||..    |.   .  ..|  | .   | |  .|.|  |.| | .|  |. .       ... .||..   | .. ||..|.. . 
GWiek.naPelareilnilkvvrd...s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2005-2132 1.1e-08 29.5 In-house 11-125 (130) alignment 
Range on Protein: 2005-2132
Range on HMM: 11-125/130.0
KlnklptepGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLTNLLEKDkkkciEYWPSAGNHKRYGELEVIAREVKDEGSYVLR
.        | .|||| |.    . . .. .| | |..  |||.|. |.    .|.|  . |.|     |||| .   . | |  ...   .||  ..  
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknika

KFEVGKPDRTTNRLNITQYHYTIWPDMG
..  .. |       .| .. . ||  |
snleiesdlneshqaltmfqisnwpsdg
subfamily_hpo-7_pd Subfamily hpo-7 2322-2494 3.6e-08 27.6 In-house 36-210 (263) alignment 
Range on Protein: 2322-2494
Range on HMM: 36-210/263.0
RKNVHVCtqcpLMSTVGDFWRLVWDYDIHTIIHLNEMDS----TCGQYWPDS--DKTNFGSFTIelLSDRTLTDTMT-ERVLKVTTSKKKGERQITQLQY
|||...     |. |.  |.. .     .... | ..       | .|.|    .|  .   ..   . ..  |..   ..|  | ..||  ..... .|
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqsdvllktlellstlgeKkkthtvkhysy

LGWPNDslvpRSKMDFFELLTQVDNNNTSeKKFLVVCMDGVGASPTFLAANAAID----RVREDKTVDI--FSAVKRLRKSRPGVV
 ||..     .  ... | |  .. .  | |.  |.|  |.| |  |  |. .       ... .||..   | .. ||.||.. .
kgWiek....ndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkrai
PTEN_1 2118-2209 2e-07 26.0 In-house 92-186 (196) alignment 
Range on Protein: 2118-2209
Range on HMM: 92-186/196.0
LNITQYHYTIWPDMGVPESSQpLLDFRDIVKNANPA-D-SGPIIVHCSAGVGRTGTFITINCMIEMIeaekkIDVFNFINEMRKRR-------AFMVQVQ
 .  .|.   ..| |.|  |. |.|. . ....  . .  . ..||| ||.||.|| .    |  .       .. . .  .|..|       ... ...
ksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerll

Q
.
e
SKG6 Transmembrane alpha-helix domain 1858-1893 2.3e-07 20.1 Pfam-A 2-40 (40) alignment 
Range on Protein: 1858-1893
Range on HMM: 2-40/40.0
PTT-GGPNSLAVGLGVGVPILLIIMVS-SGFI-VYKKRR
|.  ...|. |...||..|.. |. |   ..| ||....
psdkdstntvaIavgVviPVgvIalvLlvfLilvyRRkk
PTPc_motif_SM00404 2145-2221 2.7e-07 25.6 In-house 71-137 (140) alignment 
Range on Protein: 2145-2221
Range on HMM: 71-137/140.0
DIVKNAnPADSGPIIVHCSAGVGRTGTFITINCMiemieAEKKIDVFNFINEMRKRRafmVQVQQQYEFIYEtLLQW
|...||  .. | ..||| ||| |..|.|.  .|      ...... . .. ...||   ...... .|... |...
dfiena.ekkggkvlVHCqaGvSRSatliiaYlm.....ryrqlslaeayefvkerR...piispnlnfvrq.Liey
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1987-2074 3.8e-07 24.0 In-house 37-126 (347) alignment 
Range on Protein: 1987-2074
Range on HMM: 37-126/347.0
NKPKNRYKNIITYDEHRVKLN-----KLPTEPGADYINATFIDGYKKENAFIASQGPNAASLNDFWQMVYEQRTSTIVMLtnlLEKDKKKCIE
.  ||| |.    |. || |      . ....   ||||. |   . .. .| .| |   .. |||.||.  . . .| .   .|  | ..||
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti...fepikdeaie
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2303-2403 4.3e-07 23.6 In-house 84-187 (349) alignment 
Range on Protein: 2303-2403
Range on HMM: 84-187/349.0
GDEVDDNDYINASFFDVEG--RKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNEMDST----CGQYWpdsDKTNFGSFTIELLSDRTLTDTMTERVL
 |    .||||| .. .     .. ...|| || ||| ||....    .. .. ||. . .    | .||   .. .. ..|. |      .  .   .|
sdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw...qelsysnitvklqnsslyianvqGnsl

KVTTSKK
.| | |.
rvstvkd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2442-2507 4.8e-07 23.9 In-house 226-291 (297) alignment 
Range on Protein: 2442-2507
Range on HMM: 226-291/297.0
TSEKKFLVVCMDGVGASPTFLAANAAIDRVREDKTVDIFSAVKRLRKSRPGVVDELERYEFCYDVL
  .   || |  ||| |   . ... ....| ..  |. . .. ||. |. .|  ||..|..||. 
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_DSP23_pd Subfamily DSP23 2119-2218 7.2e-07 24.0 In-house 51-144 (148) alignment 
Range on Protein: 2119-2218
Range on HMM: 51-144/148.0
NITQYHYTIwPDMGVPeSSQPLLDFRDIVKNANPAdSGPIIVHCSAGVGRTGTFITinCMieMIeAEKKIDVFNFINEMRKRRAFMVQVQQQYEFIYE--
|.| ..  | .|.  | . . . .|  .|..|.   .  . |||  | |||||...  |   ..  |.|.   . | |.|..|   |.  .| . ...  
nltlvrlri.ddyhpp.aleqvvefvrvveeaeek.neavsvhcllgrgrtgtmla..cy..lv.kerklaaaeaiaevrrlrpgsvetveqeklvrdye

TL
|.
tf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2301-2357 1.1e-06 22.4 In-house 62-118 (347) alignment 
Range on Protein: 2301-2357
Range on HMM: 62-118/347.0
TKGDEVDDNDYINASFFDVEGRKNVHVCTQCPLMSTVGDFWRLVWDYDIHTIIHLNE
 ..   | . |||||    .  .. .. || || .|| |||..|    .  .. . |
knsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1987-2137 1.3e-06 21.4 In-house 27-158 (169) alignment 
Range on Protein: 1987-2137
Range on HMM: 27-158/169.0
NKPKNRYKNIITYDEHRVKLNKLPTEPGADYINAtfidgykkenafiasqgpnaaslndfwQMVYEQRTSTIVMLTNLLEKD----KKKCIEYWPSAGNH
|. |||    ..    ||||...  . |.|||||                           .|..|  .| ||.| .  .|.    .|.  .  |.    
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilg

KRYG-ELEVIAREVKDEGSYVLRKFEVGK-----PDRTTNRLNItqYHYTIWPDMGVPESS
. |   | | .  |.   | |   |||       .|  |..|..  .||. ||. |||.| 
ewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsl..lhystwpqngvpqsp
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2264-2330 1.6e-06 22.2 In-house 32-94 (95) alignment 
Range on Protein: 2264-2330
Range on HMM: 32-94/95.0
APMESTGSDQKGSLPVNAKKNRYPDRVPVDKFKPLLMTKGdevdDNDYINASFFDVEGRKNVHVCTQ
 .| |  .   ||   |  |||. . .| |  .  | ||     | ||||| | |   |||.....|
ismtsgapytvgsseanipknrflnifpydatrvvlttkr....dsdyinacfvdgyarkncyiaaq
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1987-2137 1.8e-06 20.9 In-house 26-157 (169) alignment 
Range on Protein: 1987-2137
Range on HMM: 26-157/169.0
NKPKNRYKNIITYDEHRVKLNKLPTEPGADYINAtfidgykkenafiasqgpnaaslndfwQMVYEQRTSTIVMLTNLLEKD----KKKCIEYWPSAGNH
|. |||    ..    ||||...  . |.|||||                           .|..|  .| ||.| .  .|.    .|.  .  |.    
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilG

KRYG-ELEVIAREVKDEGSYVLRKFEVGKPD-----RTTNRLNItqYHYTIWPDMGVPESS
. |   | | .  |. . | |   |||           |..|..  .||. ||. |||.| 
ewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsl..lhystwpqngvpqsp
subfamily_CDC14_pd Subfamily CDC14 2130-2208 2.1e-06 21.8 In-house 243-311 (328) alignment 
Range on Protein: 2130-2208
Range on HMM: 243-311/328.0
DMGVPESsQPLLDFRDIVKNAnpadSGPIIVHCSAGVGRTGTFITINCMIEMieaekKIDVFNFINEMRKRRAFMVQVQ
| ..|.. . .  | .|...|    .| |.||| ||.|||||.|.   | .      ..   . |  .|  |  .|  .
DGstPsd.aivkkfleiaeka....eGaiavhCkaGLGrtGtLiacylmkhy.....rftaaeaiawlricrPGsvigp
subfamily_PTEN_pd Subfamily PTEN 2158-2214 8e-06 20.9 In-house 117-172 (184) alignment 
Range on Protein: 2158-2214
Range on HMM: 117-172/184.0
IIVHCSAGVGRTGTFITINcMIEMIEAEKKIDVFNFINEMRKRRAFMVQVQQQYEFI
..||| || ||||. |.   ....   ||. .. .. .|.| . .  |..  |  ..
vvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqrRYv