Gene SpurPTPRB-like-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTPRB-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP112_AA protein Get Run
SpurP112_AA_81-358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 77-359 2.4e-136 448.5 In-house 7-280 (288) alignment 
Range on Protein: 77-359
Range on HMM: 7-280/288.0
RPSkkimfaQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLP
.|       ..|||.||||..|||.|||||.|.|| ..||..|.|.|..|||.|||||||..||.||.   | |.||||||||.......|||||||||.
spv......akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPla

NTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVAL
.|...|||.|.|.|.|||||.|.||||||||||.|||...||...|.||||||.||..|.|..|.||..||.|||..|.||||||.|||||.|.|||..|
dtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllel

LYQVKMTSQEDgalTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
|.|||...|.|   |||||||||||.||||||||.|.|..|...   .||||.||||||||.||..|||||.||.......|||||
lrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_PTPRB_pd Subfamily PTPRB 74-359 1.7e-120 396.5 In-house 2-286 (293) alignment 
Range on Protein: 74-359
Range on HMM: 2-286/293.0
THSRPSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQG
..|.| |. .|..||.||.|... .||.||..| |..| .||..|..|.|..|||..||||||..||.|   |.| |.|||||.|| . . .|..|||||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPL
|||.|.|.||.||||.|.|.|||.|.|||.||.|||.|||. ..|.|.|...|||| ....|... |.|.| |. .| .|..|....|.||||| .|..|
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

VALLYQVKmTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
......|. ...|. | ..||.||||||.|||||||| |.|..||..   .||.||.|.||.|||.|..||||  |||..|. .|.|..
ldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRD_pd Subfamily PTPRD 82-358 3.1e-96 318.3 In-house 8-281 (564) alignment 
Range on Protein: 82-358
Range on HMM: 8-281/564.0
IMFAQHVAKMSARNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDH
  ...||||. | ..  |. ||...    .   ...|..  |  |||. ||..|| .|| |   .|. | ||||||.|   . ...||||||||..||. 
aelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetied

FWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQkPHLHGNVTVTLVGSKQTEHFIQRTLLIGKK--GTELTVTHYQYLAWTDHGVPASTAPLVALLYQ
|| |||| . |||||.| |.| ||.||..|||. . .  .|..||||. ... .... ||. . ||      .|..... .| ||||| |...|..|. .
FWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirk

VKMTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|. ...     .|||.||||||.|||||||. |.... |.     . .|| ..|..||.||  .|||  |||..|...|  .
vralne...pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
0051299 (Phosphotyrosine protein) phosphatases II 84-358 3.1e-92 304.4 In-house 10-286 (288) alignment 
Range on Protein: 84-358
Range on HMM: 10-286/288.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---NDYINASYIADDQGNRKYIATQGPLPNTIDHFW
....| |. |... |. .|.. |...   . ...|.   | .|||...|||||..||.|. . |   .||||||||   . .||.||||||||||...||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

EMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG------KKGTELTVTHYQYLAWTDHGVPASTAPLVALL
 |||| . ..|||.| ||| |..||..|||. ...  .|..||||.  .. .....||| .       ..|...||||..|..| ||||| |. .|...|
rmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

YQVKMTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 .|.   .   .  ||..||||||.||||||||.|.|.. ...      .|. ..|..|||||  .|||. ||.......| ..
rlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 72-358 1.6e-91 302.1 In-house 19-299 (308) alignment 
Range on Protein: 72-358
Range on HMM: 19-299/308.0
ATTHSRPSKKIMFAQHVAKmsARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLkgEVGNDYINASYIADD--QGNRKYIATQ
 ...| .   . ..... |  | .. ... |.. |...  ..  .||.  .| ||||...|||||..|| |  . |.|||||||.       .||.||||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq

GPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTG--QKPHLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPA
||||||...|| |||| . ..|||.| ||| |. ||..|||.   ...  .|..||||.  .. .....||| . .  .| ..||||..|..| ||||| 
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

STAPLVALLYQVKMTSQEdgaltGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|...|...| .|. . ..     |||.||||||.||||||||.|.|.. ...      .|. ..|.||||||   |||. ||..|.|..| ..
speilldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0046845 (Phosphotyrosine protein) phosphatases II 99-358 1.6e-88 292.1 In-house 2-274 (284) alignment 
Range on Protein: 99-358
Range on HMM: 2-274/284.0
FSDEYNSLPAMEKIR--AVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYIADD-----QGNRKYIATQGPLPNTIDHFWEMVWETK
. .|.  |. .   .   ..||.   | .|||...|||||..|| || . |    .|||||||.          ..|.||||||||||...|| |||| .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

ASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGK---KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEd
...|||.| ||| |..||..|||. ...  .|..||||.  .. .....||| . .   .| ..||||..|..| |||||.|...|...| .|.   .. 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

GALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
    |||.||||||.||||||||.|.|.. ...   .  .|. ..|..|||||   |||| ||.......| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 92-358 3e-87 287.8 In-house 7-272 (273) alignment 
Range on Protein: 92-358
Range on HMM: 7-272/273.0
SARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLkGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTI
.. .....  |.. |. . ..   .||.  .| ||||...|||||..|| | |. |.|||||||.   . .||.||||||||||...|| |||| ....|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMMTALVEGGKTKCEHYWPTGQK--PHLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE--DG
||.| ||| |. ||..|||. .   .  .|..||||.. .. .....||| . .   | ..||||..|. | |||||.|...|. .. .|. . ..  ..
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

altGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
   ||..||||||.||||||||.|.|.. ...      .|.  .|..||.||   |||. ||..|....| ..
...gpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 90-358 3.7e-87 287.7 In-house 6-277 (297) alignment 
Range on Protein: 90-358
Range on HMM: 6-277/297.0
KMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLkGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKAS
.... .. ... |. .|. . ..   .||.. .| .|||...|||||..||.| .. |.|||||||.   . .||.||||||||||...|| |||| . .
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIVMMTALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQ--TEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE-
.|||.| ||| |. ||..|||.  ...  .|..||||.. ..   .....||| . .  .| ..||||..|. | ||||| |.|.|.... .|.   .. 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-DGaltGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 .|   ||..||||||.||.|||||||.... ..... .  .||  .| ||||||   |||| ||..|....| |.
psg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 84-358 1.6e-86 285.8 In-house 5-276 (317) alignment 
Range on Protein: 84-358
Range on HMM: 5-276/317.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIrAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---NDYINASYIADDQGNRKYIATQGPLPNTIDHFW
. ... .. .... ....|.. |. . .    .||.   | ||||...|||||..||.|. . |   .|||||||.   . .||.||||||||||...||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

EMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVK
.|||| . ..|||.| |.| |. ||..|||. ...  .|..||||.. .. .... ||| .   ......||||..|..|.||||| |. .|...| .|.
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

MTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
   .      ||..||||||.|||||||||..... ...      .|.  .|..|||||   |||. ||..|....| ..
eale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleyl
DSPc_SM00195 99-358 1.9e-85 281.7 In-house 2-262 (263) alignment 
Range on Protein: 99-358
Range on HMM: 2-262/263.0
FSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
.. |...| .... . .| |.  .| .|||..|||||| .||.|| |    |.|||||.||  .. ..||||||||||.|...||.||||.| ..|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQTE-HFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgalTGPI
  .| ||.||..|||   ...  .|...|.||  .... ..|.||| . |.|  .. .||.||| .|.||||| || ....|| .|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGIGRTGTFIAADMLMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.||||||.||||||...|.... ... .    .||  .| .||.|| ..|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 99-358 1.9e-85 281.7 In-house 2-262 (263) alignment 
Range on Protein: 99-358
Range on HMM: 2-262/263.0
FSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
.. |...| .... . .| |.  .| .|||..|||||| .||.|| |    |.|||||.||  .. ..||||||||||.|...||.||||.| ..|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQTE-HFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgalTGPI
  .| ||.||..|||   ...  .|...|.||  .... ..|.||| . |.|  .. .||.||| .|.||||| || ....|| .|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGIGRTGTFIAADMLMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.||||||.||||||...|.... ... .    .||  .| .||.|| ..|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045450 (Phosphotyrosine protein) phosphatases II 75-358 2.7e-84 278.8 In-house 5-304 (307) alignment 
Range on Protein: 75-358
Range on HMM: 5-304/307.0
HSRPSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEK--IRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYI--------ADDQ
.|.. .  .. ..|... . .. |.  |...|. ...  .   ..|.   | ||||...|||||..||.|. . |    .|||||||.            
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG---KKGTELTVTHYQYLA
 .||.||||||||.|...||.|.|| . ..|||.| ||| |. || .|||. . .  .||.||||.. .. .... ||| .    ..| ..||||..|..
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WTDHGVPASTAPLVALLYQVKMTSQEDgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
| ||||| |...|.... .|.   .|.    ||..||||||.|||||||||....  ...   . ..|.  .|..|||||   ||.. ||..|....| |
wpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

I
.
l
0039614 (Phosphotyrosine protein) phosphatases II 77-358 1.2e-83 276.3 In-house 12-289 (297) alignment 
Range on Protein: 77-358
Range on HMM: 12-289/297.0
RPSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEKIraVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYIADDQG-NRKYIATQGP
 | .  ...... .. | .. ..  |. .|. .      ..|.   | ||||...|||||..||.||.| |    .|||||||.      .||.||||||
ipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

LPNTIDHFWEMVWETKASTIVMMTALVEGGKtKCEHYWPTGQKphLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLV
||.|...||.|||| . ..|||.| ||| |. ||..|||. .    .|..||||.. .. .....||| . ..| ..||||.||. | ||||| |.. | 
lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelll

ALLYQVKMTSQEDgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 .| .|.   .|.    ||..||||||.|||||||||..... ...      .|.  .|..|||||   |||. ||..|....| |.
eflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 85-359 9.6e-83 272.5 In-house 3-277 (281) alignment 
Range on Protein: 85-359
Range on HMM: 3-277/281.0
AQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
 .|....|. .| ||  ||..| |..   . | ...  |  |||..||  ||  ||..   . .  .|||||....  .|...|||||||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLI-GKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMT
||||.|.|.|||.|. .|.|| || .||| ...    |.|||. . .......|.|.. .  ..| . .|.. .|.|| ||||||.|. |.    .|. .
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

SQEDGAltGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
....     |...|||||.|||||.|| | |..|.....    .|.  .||.||..|. .|||. || ......|  ..
tekktk..aplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldald
0043336 (Phosphotyrosine protein) phosphatases II 84-357 1.3e-82 272.6 In-house 7-276 (278) alignment 
Range on Protein: 84-357
Range on HMM: 7-276/278.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKiRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFW
........ . .. ... |. .|. . .    ..|.   | ||||...|||||..||.|.    . ..|||||||.   . .||.||||||||.|...||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

EMVWETKASTIVMMTALVEGGKTKCEHYWPtgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVK
.|||| . .||||.| ||| |..|| .|||  ...  .|..||||.. .. .....||| .   ..| ..|||||.||.| ||||| |...|. .| .|.
rmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavr

MTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
   .      ||..||||||.||||||||...|.. ...      .|.  .|..||||| . |||. ||..|....| .
eale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPN6_pd Subfamily PTPN6 93-359 9.1e-82 269.5 In-house 22-298 (306) alignment 
Range on Protein: 93-359
Range on HMM: 22-298/306.0
ARNNDGFSDEYNSLPAME--KIRAVTVARNARNDDKNRFRNILPYDYNRVQL--KGEVGNDYINASYIADD--QGNRKYIATQGPLPNTIDHFWEMVWET
  .. ||..|...|  .|  |    . .. ..|  |||..||||.| .|| |  .. .|.|||||.|| ..  . ...|||||| |..|.  ||.|||. 
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

KASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG---KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE
..  |||.|  || || || .|||. .. . .|...|| | .|.....| |.|..    ||..| .| .|.. .| |||||...  ....| .|.. ..|
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

DG-ALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
   | .|||.||||||||||||||  |.|.. |...     |||  .| ..||||  ||||  || ......   ||
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 84-358 1.1e-81 269.4 In-house 7-280 (318) alignment 
Range on Protein: 84-358
Range on HMM: 7-280/318.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFW
...||... .  .  .| ||. |   |.  . . . .  |  |||. |||.||  ||.|.   ||.| |||||.||   . ...|||.|.|||.||. ||
leshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfW

EMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE--LTVTHYQYLAWTDHGVPASTAPLVALLYQVK
 |||| ....|||.| ..| ||.|...|||  .... .|...|.|  ........ |.. . ....|   .|  |.| .|.|.|||.|.| |..|. ||.
rmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

MTSQEDGAltGPIIVHCSAGIGRTGTFIAADMLmnaIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 . |. ||  |||.||||||.||||.||| |.|   ..|  |   .|. .|| .|||||  .|||  ||.... ..|  .
kaqqksga..gpivvhCsaGvGrtGvfiavdil...lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
Y_phosphatase Protein-tyrosine phosphatase 123-355 1.1e-78 259.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 123-355
Range on HMM: 1-234/235.0
NDDKNRFRNILPYDYNRVQLKGEVG-NDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP-TGQKPHLHGN
| .|||...||||| .||.|||. | .|||||.|.   . ..|.|||||||..||..||.|||. | ..|||.| |.| |..||..||| . ...  .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSK-QTEHFIQRTLLIGKKGTEL---TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSqedGALTGPIIVHCSAGIGRTGTFIAADMLMNAI
..|.|.  .| ...... |.| . ||..|    .|....| .|.|||||.|. .|. |. .|. ..    | .||..||||||.||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..      .|.  .| .||.|| ..||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 123-355 1.1e-78 259.3 In-house 1-234 (235) alignment 
Range on Protein: 123-355
Range on HMM: 1-234/235.0
NDDKNRFRNILPYDYNRVQLKGEVG-NDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP-TGQKPHLHGN
| .|||...||||| .||.|||. | .|||||.|.   . ..|.|||||||..||..||.|||. | ..|||.| |.| |..||..||| . ...  .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSK-QTEHFIQRTLLIGKKGTEL---TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSqedGALTGPIIVHCSAGIGRTGTFIAADMLMNAI
..|.|.  .| ...... |.| . ||..|    .|....| .|.|||||.|. .|. |. .|. ..    | .||..||||||.||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..      .|.  .| .||.|| ..||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 85-358 1.5e-77 255.8 In-house 11-283 (319) alignment 
Range on Protein: 85-358
Range on HMM: 11-283/319.0
AQHVAKMSARNNDGFSDEYNSLPAMEKIrAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
.... .. .  . ..  |.. |   ..   .. | . .| .|||..|||.||  ||.|   .|  | ||||||.|   | ..|.||||.|| |||. || 
kerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MVWETKASTIVMMTALVEGGKTKCEHYWPTGqKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTEL---TVTHYQYLAWTDHGVPASTAPLVALLYQVK
|||| ..|..||.| ||| .| |...|||.  ...  |...|||   ...|..| | | . || .|.   .|.|.||..|.||.|| ..  |..|| ...
mvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir

MTSQEdgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 . ..     |||.||||||.|||||||. |. .. ... ..   .|.  || .|| ||  .||.  ||.... ..|  .
ksrek..tqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPN12_pd Subfamily PTPN12 109-359 3.6e-77 254.1 In-house 26-278 (290) alignment 
Range on Protein: 109-359
Range on HMM: 26-278/290.0
MEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKC
.||.   ..... .|  |||...|||||..||.|.    | |.|||||..|   .|. .|||.|||||.|.| || |.||.. . .||.  .|| ||.||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

EHYWPTGQKPHL-HGNVTVTLVGSKQTE-HFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgALTGPIIVHCSAGIGRTG
|.|||  .. .| .|...|||   |...  |. ||| . ..... .|. ..| || |||||.|. .|..|. .|. . .   .   |..||||||.||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtG

TFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
| || |.  ..... . .. .|.   |..||.||..||||  || .... ...|..
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 78-358 5.4e-77 254.0 In-house 8-290 (298) alignment 
Range on Protein: 78-358
Range on HMM: 8-290/298.0
PSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEK---IRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGP
.. |... . .|.. . .  |...|.. | ....       .|||. .| .|||. .|...|. || |.    .   ||||||..   .|.  .||||.|
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

LPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAP
|..|.  || ||.| ...||||.| |.| .|||...|||. .. . .|..||.|  ...   .|.|.| . ||   .| .| . ..  |.|.|||. .  
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenats

LVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
...|| .|... |. |    |.||.||||.||.||||| | ... ....     .|.  .|  ||..|. .|||  ||.... ..|  .
vldllrkvrasqqqag..nkpvivqCsaGvgRsGtfiaidsvlervkke...qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN13_pd Subfamily PTPN13 99-358 4e-76 250.9 In-house 13-269 (273) alignment 
Range on Protein: 99-358
Range on HMM: 13-269/273.0
FSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGndYINASYIADDQ--GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTA
 ..|.. |  .  .  ..|.....| ||||.||.||||  ||.|..| |  |||||.|       . .|||.|||||.|.. || |||| ||. |.|.| 
PaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LVEGGKTKCEHYWPTGQ--KPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDgalTGPII
 .|.|| ||. |||  .  |  ... ..|.|.. .. . | .|.| . .. .     |.| .. .| |||||.|.|.|. .. .|.   . |   .|||.
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.d...agPiv

VHCSAGIGRTGTFIAADMLMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|||||||||.||.|. |.... |.| .    .|.  .| |||||| ..|||  |||. ....| ..
vhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevl
0045098 (Phosphotyrosine protein) phosphatases II 98-358 4.4e-76 251.2 In-house 8-272 (278) alignment 
Range on Protein: 98-358
Range on HMM: 8-272/278.0
GFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQlkgevgnDYINASYIADDqgNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTAL
 .. |.  |...  .  .|.|    | ||||...|||||..||        ||||||||     ..|.||||||||.|...||.|.|| . ..|||.| |
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

VEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG------KKGTELTVTHYQYLAWTDHGVPAST--APLVALLYQVKMTSQE------
||.|. ||..|||  ...  .|..||||.  ....... ||||.       . .....|||..|| | ||||| ..  ...  || ...   ..      
velgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DGaltGPIIVHCSAGIGRTGTFIAADMLMNAIqrstaTDYIDIAGTVAKLREQRTS-LVQTLYQYIYLHRIMLSLI
       .|   ||..||||||.|||||..||....  .      . .|.  .|..||.||    ||.| ||..|.. .| |.
sslllldsg...gpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPRG_pd Subfamily PTPRG 84-359 5.2e-76 251.1 In-house 6-288 (563) alignment 
Range on Protein: 84-359
Range on HMM: 6-288/563.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIR--AVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---N-DYINASYIADDQGNRKYIATQGPLPNTID
||.|||.. | .. ||| |...|    . .   .. ...  |  |||  ||..||  ||.|..  |   . |||||.||   | ....|||||||..|.|
fakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfd

HFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGK------K--GTELTVTHYQYLAWTDHGVPASTAP
 || |.|| ....|||.| ||| |. ||. |||. ...   |...|||. ....    .||| | .      |   ||..|..|.|  | ||||| ...|
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

LvalLYQVKMTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
    |  ||  |.   | .|||.||||||.|||||.|. | |.. ||.    . ... |.. ..| ||  ||||  |||.|| ..|..| 
v...LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalleaia
0040439 (Phosphotyrosine protein) phosphatases II 116-358 8.5e-76 250.1 In-house 4-246 (249) alignment 
Range on Protein: 116-358
Range on HMM: 4-246/249.0
TVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTg
.||.   | ||||...|||||..||.|   .|  ..||||||||   . .|..||||||||.|...||.|.|| . ..|||.| ||| |. ||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

QKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgALTGPIIVHCSAGIGRTGTFIAADM
...  .|..||||.  .. .....||| .   ..|...||.|.||. | ||||| |...|.... .|.   .|.    ||..||||||.|||||||||..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaayl

LMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
... ...      .|.  .|..||.||   ||.. ||..|....| |.
mleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 84-358 6.9e-74 243.7 In-house 9-283 (305) alignment 
Range on Protein: 84-358
Range on HMM: 9-283/305.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKirAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGND---YINASYIADDQGNRKYIATQGPLPNTIDHFW
.|... .... ...|.  .|.||.  |.  .. | ..  |  |||...| ..| .|..|. .  .|   ||||||.   ... |||..||||.||.. ||
laayikearvysdkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfW

EMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLLIGK---KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQ
....|.| |||||.| |||||| ||. |||. ..  . .|...|.|  .|... .|.| | | .   .  . ||..||   | ||||| ... |. |. .
rliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr

VKMTSQEDGAltGPIIVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|. . ..|     |..||||||.||||.||| |. ..   |  . . .|... . .||..|  .|||| || .|| ..  ||
vqkdqkkdkg..vpllVhCsagvgRtGvfiavdiale...rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPRA_pd Subfamily PTPRA 86-355 2.8e-73 241.7 In-house 21-292 (330) alignment 
Range on Protein: 86-355
Range on HMM: 21-292/330.0
QHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEM
. . . || .|  | .|.|.||| .   .. .| .  | .|||. ||||||..|| |   .|.   ||||||.|   .   |.||.|||. .|.. || |
eeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrm

VWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT------ELTVTHYQYLAWTDHGVPASTAPLVALLYQ
.|| |..||||.| | |  ..||. |||. .    .||..|..  .. ....  | .|. ...       .  |. . . .| | |||. .  .. || .
iweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk

VKMTSQEDGAltgPIIVHCSAGIGRTGTFIAADMLMNAIQrstATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
|| . |  .    ||.||||||.|||||||. | ... ..   |   .|. ..| .|| ||. .|||. || ......|
vkklnqqsag...pivvhcsaGvGrtGtfivldavlervk...aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll
0042113 (Phosphotyrosine protein) phosphatases II 117-358 4.2e-73 241.1 In-house 3-243 (245) alignment 
Range on Protein: 117-358
Range on HMM: 3-243/245.0
VARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgQ
||.   | ||||...|||||..||.|. .    ..|||||||.  .. ..|.||||||||.|...||.|.|| . .||||.| ..| |. ||..|||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

KPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEdgALTGPIIVHCSAGIGRTGTFIAADML
 .  .|..||||.. .. .....||| .   ... ...|.||.|| | ||||| ... |. .|  |.   .|     ||..||||||.|||||||||...
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylm

MNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.. ...      ...  .|..||.||   |||. ||..|....| |.
leqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 118-357 1.2e-71 236.4 In-house 5-241 (243) alignment 
Range on Protein: 118-357
Range on HMM: 5-241/243.0
ARNARNDDKNRFRNILPYDYNRVQLKGevgNDYINASYIADDqgnRKYIATQGPLPNTIDH----FWEMVWETKASTIVMMTALVEGGKTKCEHYWPtGQ
|.   | .|||...|||||..|| |.|   .|||||..|      ...||||||||.|...    ||.|.|| . ..|||.| ||| |. ||..||| |.
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.ge

KphLHGNVTVTLVGSKQTEHFIQRTLLIGK---KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE-----DGALTGPIIVHCSAGIGRTGTF
.   .|..||||...........||||.     .. ...|.||.||.| ||||| |...|...| .|.   .|          ||..||||||.|||||.
v..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IAADMLMNAIqrstatDyIDIAGTVAKLREQRTS-LVQTLYQYIYLHRIMLSL
|||....  .      . .|.  .|..|||||    |||. ||..|....| |
iaaylmllll......g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 91-357 6.1e-71 234.1 In-house 16-285 (307) alignment 
Range on Protein: 91-357
Range on HMM: 16-285/307.0
MSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETK
     . |.  ||..|.| |  .  .|. .  |  |||. .| ..| .||.||    .   ||||||.|   . ..|.|| |.|. .||. || |..| .
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

ASTIVMMTALVEGGKTKCEHYWPTGQKPHlHGNVTVTLVGSKQTEHFIQRTLLIGKKG-------TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMT
  .|||.. | |  . ||..|||  .. . .|.. |.|| .......|.|.| . ||.        .  |. |.|..| |  || ..  |. |..||.  
vtlivmlsnlteknrkkcakYWpiedevq.ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

SQEDgalTGPIIVHCSAGIGRTGTFIAADMLmnaIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
 . .    .||.|||||| ||.|.|.| |.|   .|.  | | .||  || .||.||. ||| | ||..|.| .|  
ykln...rsPivvhCsaGvgrsgifvaldsl...lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPN3_pd Subfamily PTPN3 102-355 9.3e-71 233.0 In-house 20-272 (280) alignment 
Range on Protein: 102-355
Range on HMM: 20-272/280.0
EYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGnDYINASYIADDQGN----RKYIATQGPLPNTIDHFWEMVWETKASTIVMMTAL
... |   .. .|...|| ..| .|||.|.|||||  ||.|| .   |||||.|.  .        .||||||||..|  .||.|||| |.|.|||.| |
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgALTGPIIVHC
|| |..|| .|||. ..   .|. .|..  ...|. .. | |.. .|    | .... |||||.||||| ..| .. .. .|. . .   . . |..|||
verGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs...gkeePvvvhC

SAGIGRTGTFIAADMLMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIML
|||||||| .|. .. .  |... .   .||   | ..|.||..||||  || ..   .|
saGigrtGvlilletalalieaaepvypldi...vrtmrdqramlvqtasqykfvCeail
subfamily_PTPRK_pd Subfamily PTPRK 85-356 3.1e-70 231.5 In-house 10-275 (314) alignment 
Range on Protein: 85-356
Range on HMM: 10-275/314.0
AQHVAKMSARNNDGFSDEYNSLPAMekiraVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
 |..|.. . .. || .||.||.         .|..  | .|||. .||.||  ||.|.   |.  .|||||..|   .  ...|.|||||..|.  || 
lqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPhlHGNVTVTLVGSKQTEHFIQRTLLIGK--KGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQV
.|.. ....|||.| ||| |. || .|||   .   .|.. |.|| ..  . ...|.. . |  .|     .| ..|.|.|.||.|| |   |..|. .|
lvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

KMTSQEdgaLTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
|....|     |.|.|||||| |||||||| |.... |.|    . .|.  .| .||.... .|.|  ||.... ..| 
kksqee...eaGrivvhCsaGaGrtGtfiaidivldmiere...gvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 99-355 1.5e-69 229.1 In-house 7-265 (274) alignment 
Range on Protein: 99-355
Range on HMM: 7-265/274.0
FSDEYNSLPAMEKIRAVTVARnarNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYIADDQG-NRKYIATQGPLPNTIDHFWEMVWETKASTIVM
. .|. .||.  . . ..|..   .  |||...||| .  || |. | .     .|||| ||   .. .. |.|||||||||.. ||.|....... |||
lekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTALVEGGKTKCEHYWPTGQKP---HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGALTGP
.| | |  ..||..|.|. ..    . .|.| .. .. ......  |.|.. .   | .|.|| | .| || .| .. .|. |. .|. . .|. | ..|
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

IIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..||||||||||| |||... .. ...   .  .|. ..|..|| .|  .|||  || ..||.. 
vvvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 113-358 1.7e-69 228.8 In-house 10-264 (270) alignment 
Range on Protein: 113-358
Range on HMM: 10-264/270.0
RAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---NDYINASYIA-DDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHY
   ..   ||.   ||...|||    ||.|. .       |||| |..  |. ..||||..||||.|. .|| |.||.|...|||.| |.| |..||| |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPTGQKP---HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTA------PLVALLYQVKMTSQEDGALTgPIIVHCSAGI
||. .|      .|...|. . ....| .|.. | . .||.|  ..|..| .| ||||| ..        |...| .|. ...|    . |..||||||.
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGv

GRTGTFIAADMLMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|||||.|| |. ........  | . |   ...||..|. |||.  || .|.. ..  .
gRtGtlialDiavrlLeetkkvdvlai...ieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 86-355 7.3e-69 227.1 In-house 13-276 (315) alignment 
Range on Protein: 86-355
Range on HMM: 13-276/315.0
QHVAKMSARNNDGFSDEYNSLPAmEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEM
 .||.  |  ..|| ..|.|.|   ... . ||..  | .|||. ||..||  ||||   . . . ||.||..|   . .|.|||.|||...... || .
tyvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrl

VWETKASTIVMMTALVEGGKTKCEHYWPTGqkPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQ
|.| . ..|||.| |||| | |.|.|||      ..|..|||..  .. ...  ||| .  .    .|  ..| .| | |||..| ||. |  .||.  .
vfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht

EDGaltGPIIVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..    |.|.||||||.|||||||. | ...   .  | . ||.   . ..|..|  .||.. || ... ..|
nsv...gaivvhcsaGvGrtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_PTPN9_pd Subfamily PTPN9 87-355 2.6e-68 225.2 In-house 6-287 (297) alignment 
Range on Protein: 87-355
Range on HMM: 6-287/297.0
HVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMV
 || . .... | | ||  . ...    .....   |  |||. ..| ||  ||.|.   ..   |||||...   . .. .|||||||..|.. || ||
lvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

WETKASTIVMMTALVEGGKTKCEHYWPT-GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVK--
|| .. .|||.| .|| |. || .|||.  .. . .|...|. |  ...|.. .|.| |   |.. . .|||.|.|.| |.||| |.| |. .| .|.  
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

-------MTSQEDGALTG-PIIVHCSAGIGRTGTFIAADMLMNAIQrstATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
       ..... | ..| ||.||||||||||||||. |. .. ..    .. .|.  || .||.||.  .||  || . .  .|
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle...evgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 84-359 3.1e-68 224.7 In-house 7-284 (290) alignment 
Range on Protein: 84-359
Range on HMM: 7-284/290.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK-----GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDH
|...||.  |..|.|| .....| . |.  .|||.    |  .|||.||..|| ||. |.      .  |.||||.|| . . ...|||||||..||. .
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHlHGNVTVTLVGSKQTEHFIQRTLLIGKKGT---ELTVTHYQYLAWTDHGVPASTAPLVALLY
||...|. | . |||.|  .| ||.||  |||. .  .  |.....|.  ......|.|.| . .| .   . .||.||  .| ..|  . ..  . ...
FWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvie

QVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
..  |   .|   ..|.||||...||...|.||..   .|..   .  ||.   . ..| |.  .|||  || ....|.|. ..
emyktqrkrg..ntsivvHCSdtvgrsavfcaaat...tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 93-355 3.6e-68 224.9 In-house 12-273 (515) alignment 
Range on Protein: 93-355
Range on HMM: 12-273/515.0
A--RNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETK
.  |.   ||.|.. ||   .|   |||..  |  |||..|||||| .||.|   . .  .||.|||||   . .. |||.|||.. ..| || .|.. .
nknrhttlfseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

ASTIVMMTALVEGGKTKCEHYWPT-GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKmtsQEDGA
 .||.|.| | || | || .|||    .    |.. | ||  .     |.|.| . |     ||| ...  | |.|||  |  |. |. .||    . | 
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevk...adhgq

LTGPIIVHCSAGIGRTGTFIAADmlmNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.| |.|.|||||.|||| .|..|   . . .   |. .|.  .| ..|..|  ||||  || ... ..|
ythpliihcsaGvGrtGvvisid...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 92-354 1e-67 223.2 In-house 14-273 (315) alignment 
Range on Protein: 92-354
Range on HMM: 14-273/315.0
SARNNDGFSDEYNSLPAMEkIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKA
  |.   ||.|.. ||  . |   .|||.  |  |||..||||.| .||.|     .  .||||||||   . .. |||.||||. ..| ||.||...|.
knrhtalfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

STIVMMTALVEGGKTKCEHYWPT-GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTsqeDGAL
.||||.| . || | ||  |||    .    |.. |.|.  ...   ..| | . |  .  ||| .|.  | |.||.  |. |. |. .||     .|  
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkk

TGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
. ...||||||.|||| .|..|  .. |.|   |. .|.  .| .||..|  ||||  .| ... ..
efsllvhcsaGvGrtGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 101-356 1.9e-67 222.9 In-house 38-289 (319) alignment 
Range on Protein: 101-356
Range on HMM: 38-289/319.0
DEYNSLPAMEKI-RAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTa
 |.. .. .       | |   .| ||||. |||..| |.|.|.   || . ||||||...  | . ||||.||||.||.. || |.|| ..||||..| 
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.

lveggKTKCEHYWPTG-QKPHLHGNVTVTLVgsKQTEHFIQRTLLIGKKGTE---LTVTHYQYLAWTDHGVPASTAPLVALLYQVK-MTSQEDGalTGPI
     | ||  |||   .. . ...| |..|  ..|. .. | . . ..| |     .| . .| | |.||| ....|. |. .|. .||.|..    .|
.....kdkcsqywplkivikeerfkvkvdsv..eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh..rani

IVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
.||||||.||||..|. |.|.. ...    . .|.  .|  ||.||  ||| | || ...  .| 
vvhcsaGvGrtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 116-356 5.1e-67 220.7 In-house 2-240 (250) alignment 
Range on Protein: 116-356
Range on HMM: 2-240/250.0
TVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTkCEHYWPTg
.||.. .| .|||. .|...|  || |. |      ||||||..   .... .|||||||..|| .|| ||.| |..||||.| |.| .|| ...|||. 
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.

QKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADM
.|.. .|.|||.|  ...   ...|.| . |.    | .| ......| | |||. .   ..|| .|. . |. |  ..|.||.||||.||.|.||| | 
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag..naPvivqCsaGvgrsGafiaida

LMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
... ....     .|.   . .||..|   |..| ||.....|.| 
vlerlkkek...vvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_PTPN1_pd Subfamily PTPN1 115-348 1e-66 219.6 In-house 24-261 (290) alignment 
Range on Protein: 115-348
Range on HMM: 24-261/290.0
VTVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
...|.. .| ..||.|.. |||. |..|. .  ||||||| .  .. .|.|| ||||||||.||||.|||| |. ..||.  .|| ...|| .|||.|..
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-PHLH---GNVTVTLVGSKQTEHFIQRTLLIGKKGTEL--TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEdGALTGPIIVHCSAGIGRTGTFIAA
   |     ...|.|.  ....... |.| . .. |.   ...|. |..|.| ||| | | .. .|..|. .        || ..||||||||.|||. .
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsGtfclv

DMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYI
| ..  |...  .. .||  .. .||..|. |.||  |  
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 116-356 1.3e-66 220.0 In-house 18-253 (284) alignment 
Range on Protein: 116-356
Range on HMM: 18-253/284.0
TVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTalveggKTKCEHYWPTG
| |   .| ||||. .||..| |.|.|.   || . ||||||.|.  | . |||||||||.||.. || |.|| ..||||..|      | ||  |||  
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

Q-KPHLHGNVTVTLVgsKQTEHFIQRTLLIGKKGTE---LTVTHYQYLAWTDHGVPASTAPLVALLYQVK-MTSQEDGalTGPIIVHCSAGIGRTGTFIA
  . . ...| |..|  ...| .. | . . ..| |    ... . .| | |.||| ....|..|. .|. .||.|..    .|.||||||.||||..|.
ivikeerfkvkvdsv..eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenh..ranivvhcsagvgrtgvyiv

ADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
 |.|.. ...    . .|.  .| .||.||..||| | || ...  .| 
ldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN23_pd Subfamily PTPN23 112-356 2.1e-65 215.4 In-house 32-278 (288) alignment 
Range on Protein: 112-356
Range on HMM: 32-278/288.0
IRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADD-QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP
 |  ..|   .. .|||.|.||||| |||.|.|.  .||||||.. |   |  ..||||.||..|.  || ||.| |.|.|||..   | ||.|...|||
arkrsiaiaklyseknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

TG-QKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE--LTVTHYQYLAWTDHGVPASTAPLVALLYQVKM-TSQEDGALTGPIIVHCSAGIGRTGTFI
.   ... .|...|||   ..||....|.| .  ....   .|.| |. .|...|||||   |...| .|.   ...   .  |..||||||.||||.| 
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

AADMLMNAIqrSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
     ....  ..    .||   | .|||||   ||.  |.  .  ..| 
lvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 83-358 7.8e-65 213.7 In-house 6-278 (287) alignment 
Range on Protein: 83-358
Range on HMM: 6-278/287.0
MFAQHVAKMSARNNDGFSDEYNSLPA-MEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
.|.. |||  |..|.||.. .  |    ..   ||..   .| ||||...||..| .|| ||||  .|||||..|   . ....|....|. ||.  ||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk

MVWETKASTIVMMTALVEGGKTKCEHYWPTGQKpHLHGNVTVTLVGSKQTEHFIQRTLLIG---KKGTELTVTHYQYLAWTDHG-VPASTAPLVALlyqV
.... . ..|||.. . |  . .| .|||...   . |. ...|.  ......|.|.| .    |.|....|. ||. .| ..| |.   . |. .    
liddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi...e

KMTSQEDGALTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.|  ..     ..|.||||...||...|.||..   .|...     ||.   . . | |.   |||  ||...  |.|  .
emyktqrkrgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 84-355 1.8e-64 212.9 In-house 10-285 (325) alignment 
Range on Protein: 84-355
Range on HMM: 10-285/325.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIrAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFW
. .|| |  |...|||. |.. ||. . | | .||    | .||||.|....| .|| |.    .   |||||||. ||..   ..|.| ||..||. .|
lvehvekkkaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlW

EMV--WEtkaSTIVMMTALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLY
 .|  |.   ...|...  ...|| .|  |||    |    | . | |.  ..   ...| | .   |||  ..|  .|. .| | ||.   | |...| 
rlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq

QVKMTSQEDGA---LTGPIIVHCSAGIGRTGTFIAadmLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
 ||  |.   |    ..||.||||||.||||.||.   |  |...      .|| | | |||..| |.|.|  ||| ..  . 
lvkavservtantkastpilvhcsaGvGrtGvfis...lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 83-355 4.7e-63 208.1 In-house 14-281 (297) alignment 
Range on Protein: 83-355
Range on HMM: 14-281/297.0
MFAQHVAKmsARNNDGFSDEYNSLPAmEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGN---DYINASYIADDQGnrKYIATQGPLPNTIDHF
 ||  | |   |. | ||.|.. ||.  .|.. |||..  | .|.|..|||||| .||.|.    .   ||.|||..   .   ..|.|| | ..|.. |
dfatlvqk..nrhtdvfseeflclpe.aniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadf

WEMVWETKASTIVMMTALVEGGKtKCEHYWPTGQKPHlHGNVTVTLVGSKQTEHFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPA--STAPLVALLY
| ||.. ..|||||.. . |. | || .||.        |.|.|.|   .. | ||.|.| . |    ..  |  ||.. | |. |.   |.. |. |. 
Wamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklis

QVKMTSQedGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.|. . .  .   ||..|||.||.|||| ... |  .  ..|   .. .|| |.| |||..|  ||||  || ... ..|
evrkdfs..qnaegPllvhclaGvGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_PTPN14_pd Subfamily PTPN14 101-358 8.7e-62 203.8 In-house 27-296 (300) alignment 
Range on Protein: 101-358
Range on HMM: 27-296/300.0
DEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG--EVGNDYINASYIADDQG--NRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTA
 ||. .| ...   ...|..  | .||||...|||. |||.|.   |  ..||||| |    |  .|.||..||||..|.  ||.||||.. . |||.|.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

LVEGGKTKCEHYWPTGQKP---HLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDG------
  |.||.|. .|.|  ..      .|.  ||   |.... .| ..| .     . | || | ||  |.|||||    . .  | .|.   ..        
eeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

ALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
    |..||||||.||||  | .|.|.....     . |||  ..|.||||| .||||| || .......  .
eskPPvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 93-355 1.5e-61 202.7 In-house 5-263 (283) alignment 
Range on Protein: 93-355
Range on HMM: 5-263/283.0
ARNNDGFSDEYNSLPAMEKIRAVTVARnaRNDDKNRFRNILPYDYNRVQLKGEVGnDYINASYIA---DDQGNRKYIATQGPLPNTIDHFWEMVWETKAS
. ||. | . .. |   ..   ...|.  .|. |||...|.|.| .||.|| |   |||||..|    ... ..|||..|.|| .|.  || ||.. |..
vnnnklfrevlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

TIVMMTALVEGGKTKCEHYWPTGQKpHLHGNVTVTLVGSKQTEHFIQRTLLIGKK---GTELTVTHYQYLAWTDHGVPAstaPLVALLYQVKMTSQEDGA
.|||.| | |. . ||  |||       .|. ||||      . ||.. ||. ..    ..| ..|||.  |.. |  |   .. .|.   |. |.    
aivmltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa...iinslvkfnkvislqtes

LTGPIIVHCSAGIGRTGTFIAAdmlMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
  |||.||||.|||||..||||   . ...   .   .|.  .|  .||||  .|||| ||  .| ..|
kkgPivvhCstgiGrtavfiaa...sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 117-352 7.2e-60 197.2 In-house 32-271 (287) alignment 
Range on Protein: 117-352
Range on HMM: 32-271/287.0
VARNARNDDKNRFRNILPYDYNRVQL--KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
 | .  .  |||. ..||.| .|| |  .|| | ||||| |.|  . . ..||.|||.. |.  || .|.||.......||  || .. || .|||  ..
aaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev

PHLHGNVTVTLVGSKQT-EHFIQRTL-LIGKKGTE-LTVTHYQYLAWTDHGVPASTAPLVALLYQV--KMTSQEDGALTGPIIVHCSAGIGRTGTFIAAD
| . |  .|.|.  ..   ..  |.| ||  .. |   |  ...|.| |.... ..  |. .  .|  ..  . |.. .||..||...||||.|...|  
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

MLMnaiQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHR
.|.   .|   .  .|.| .|..|||.|..|||.  |. .|  
vlv...srledlGrvdvaavvirlreyraalvqavvqlrllye
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 122-355 4e-58 191.4 In-house 2-236 (237) alignment 
Range on Protein: 122-355
Range on HMM: 2-236/237.0
RNDDKNRFRNILPYDYNRVQLKGEVG-NDYINASYIADDQG-NRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHG
.|  |||. ||  ||..|| |||  .  |||||.|. . .|  .||||.|||| .. | ||.|||. | | |||.| |.|| . || .|||  ..|  .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

NVTVTLVGSKQTEHFIQRTLLIGKKGTELTV---THYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDGALTGPIIVHCSAGIGRTGTFIAADMLMNaiq
 .||.|   ..   .  |.||. |..|   |     ||. .| |.|||  || |. .  ..   |.   . .|| |.|||||.|||| |.  | ..    
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsp.hvsesgpwiihcsagvgrtgiflvidamlr...

RSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..     .||   |  . |.|  ..||  ||...|. .|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPRN_pd Subfamily PTPRN 94-349 2.3e-55 182.4 In-house 26-283 (297) alignment 
Range on Protein: 94-349
Range on HMM: 26-283/297.0
RNNDGFSDEYNSLPAMEKIRAV-TVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADD-QGNRKYIATQGPLPNTIDHFWEMVWETKA
.|.| .. |...| | |   .. .||.. .| .||| ...|||| .||.|| |     .|||||| | |.   .  ||||||||..|. .||.||||  .
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

STIVMMTALVEGGKTKCEHYWPTGQkPHLHGNVTVTLVGSK-QTEHFIQRTLLIGKKGTE--LTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedG
  ||..| | | | ..|..|||     ....   | ||  .  .. .. |.. .    |.   ||| . .|.|...|||||. .|. .  .|  . .  |
vvivnltrleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..G

aLTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatDYIDIAGTVAKLREQRTSLVQTLYQYIY
  . ||.||||.| ||||..|. |...| ...      |||| |. .||.||. ||.|  |. .
.rscpivvhcsdGaGrtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfef
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 83-356 2.8e-53 175.9 In-house 6-277 (439) alignment 
Range on Protein: 83-356
Range on HMM: 6-277/439.0
MFAQHVAKMSARNNDGFSDEYNSLPAMEKIRAV--TVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTID
 | .|| |.   ... |....... ...   |.  ..| .  .. |||.... ..|. || |    |     |||| ||     .. |||||||  .| |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

HFWEMVWETKASTIVMMTALVEGGKtkcehYWPTGQKpHLHGNVTVTLVGSKQTEHFIQRTLLIGKK----GTELTVTHYQYLAWTDHGVPASTAPLVAL
.|| .|.| |..||||.| |||  |     |||. ..   .|...|      .  ... | . . ..      | || ...|.|| |. ||| .. .. .
dfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

LYQVkmTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQrstATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
|  .   | .|   .||..||||||.||||| || |. .. ..   . . .|| | |  ||.||. .||.| ||....  .| 
lrai..nsandkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 86-355 1e-50 167.3 In-house 8-233 (392) alignment 
Range on Protein: 86-355
Range on HMM: 8-233/392.0
QHVAKM-SARNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
|  | .   | .  |..|.  ||   .|   |||..  |  |||..|||||| .||.|        .||.|||||   . .. |||.||| . ..| ||.
qfpafveknrhsalffeefhdlpgp.diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwr

MVWETKASTIVMMTALVEGGktkcehywptgqkphlhgnvtvtlvgskqtehfiqrtlligkKG-TELTVTHYQYLAWTDHGVPASTAPLVALlyqVKMT
||.. ...||.|.| | ||                                           ||    ||. ...  | |..||  |. |. .   .|  
mvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkf...ikev

SQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
. . |  | |.|.|||||.||||  |. | ..    ..  |  .|.   |...|..|  .|||  || ...  .|
kadfGqythpliihcsagvgrtgvvisidsvva...hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 103-357 5.2e-50 165.0 In-house 13-294 (297) alignment 
Range on Protein: 103-357
Range on HMM: 13-294/297.0
YNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGE-VGNDYINASYIA--DDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVE
...|    .  . ..|.      |||.|.|| .| .||.|..   ..||||| |..  |.. . ||| .|||| .|.| ||..|.|    .|||.. | |
kdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

GGKTKCEHYWPTGQKPHL-HGNVTVTLVGSKQTEhF---IQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVAL--------------LYQVK---
.|. ||  |||  ..  |  |.| |  . |   | |   |   | .  .  .  |.| |.|.| |||||.    || .              |  |.   
dGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemft

-------MTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATdyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
        . . .     ...||||||.||.|  . .|.... ...       |.|  . .|||||. ||||| |. .|. ..|  
amvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavlkk
subfamily_CG7180_pd Subfamily CG7180 113-356 1.9e-49 162.9 In-house 32-288 (296) alignment 
Range on Protein: 113-356
Range on HMM: 32-288/296.0
RAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKtKCEHYW
     . .. | .|||  ...||||||| |   .||  .|||||.|.     ...|| |..|  .|.| ||..|.. ..|..|..|   .  | ..  ||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PTGQkPHLHGNVTVTLVGSKQTEHFIQRTLLIGKK------------GTELTVTHYQYLAWTD-HGVPASTAPLVALLYQVKMTSQE--DGALTGPIIVH
|  .  . .|.. | .| .||  .. .||. . ||              . .|...|.  |   . || ||. |. |. .|..  ..  .   .||..|.
pnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
.| | .|.| ..|.|. .. ...   .. .|. . | .||..|  ||..  .| |.  ..| 
ssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
0041856 (Phosphotyrosine protein) phosphatases II 123-357 2e-49 163.0 In-house 1-170 (182) alignment 
Range on Protein: 123-357
Range on HMM: 1-170/182.0
NDDKNRFRNILPYDYNRvqlkgevGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTalveggktkCEHYWPTGQkphlhgnvt
| ||||...|||||..|       ..|||||.... .. ....|||||||..|. .|..|..| . .|||..|         .|.|||.           
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.........

vtlvgskqtehfiqrtlligkkgtELTVTHYQYLAWTDHGVPAsTAPLVALLYQVKMtsqedgaLTGPIIVHCSAGIGRTGTFIAADMLMNAiqrstatd
                        | ....|.|| | |||||  .  |.... .|.          ||..||||||.|||||..||....          
........................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl........

YIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
 ...  .|. .|..|   |.|. ||..|....| |
gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 90-355 3e-48 159.1 In-house 8-290 (301) alignment 
Range on Protein: 90-355
Range on HMM: 8-290/301.0
KMSARNNDGFSDEYNSLPAMEKiRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV-----GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVW
.. | ....|...|..|  .|. .  ||  . .|   |||.|| .|| ||. || .       ..||||||| . . ..|.||.|||. .|.  || ..|
hvaakhsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

ETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLL-----------------IGKKGTELTVTHYQYLAWTDHGVPAS
. | ..|||.| | || |.|||.|||....  .  |..||||| ..    |. | |                  . .. .  .|. .|   | ..||   
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

TAPLVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
 .  .  . .| .. |  |   ||..||||....|.|.... ..   ..    |   .|. . .  .| ..   |.|| ||. .. .. 
prtvLqviddvihrqqkig..ggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 83-359 6.1e-48 158.1 In-house 8-288 (305) alignment 
Range on Protein: 83-359
Range on HMM: 8-288/305.0
MFAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEM
   . | .   .   |.  |....  .. .  .   ..|.. .|||....   | |||.|.|    .|| | |..     ...| || || .|   || |
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwym

VWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHG-----NVTVTLV------GSKQTEHFIQRTLLI--GKKGTELTVTHYQYLAWTDHGVPASTAP
 .. |  .| |.  |.| |  || .|... .|. |.       ..| .         |...  ...| |.  |  .. . |||| .  | | ||||.   
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla

LVALLYQVKmtsqedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
.. || . .       .. |||.|||||||||||. .  . ... .      .  |    . |.||||   .||  ||...|...|  ..
ilellekar.......pskgpivvhcsagigrtgsvvmleyildqllagqiie..dtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 98-357 1.1e-47 157.6 In-house 17-276 (307) alignment 
Range on Protein: 98-357
Range on HMM: 17-276/307.0
GFSDEYNSLpAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGE-VGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTA
 . ||.. | |  .  .|||     | ||||....   | .|. .| . .  ||| | |.      .|.|..|||| ||. .|| |. . |  ...|.  
alvdefrvl.akktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

LVEGGKTKCEHYWPT--GQKPHLH---GNVTVTLVGSKQ---TEHFIQRTLL-IGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTsqedgal
..| .| ||| |||   |||         ..|. .|.|.    |..|. | | .   .   |..|.|.  | |.|||      . ||  |.         
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd.......

TGPIIVHCSAGIGRTGTFIAADMLMNAIQRStaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
| |..||||||.||.|| .|  .... . .    .  |.   | .||.||   .|| .||.||||..|. 
tnpvvvhcsaGvGrsGtivaislvqdkmiaG..inckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 118-355 2.1e-47 156.3 In-house 3-238 (239) alignment 
Range on Protein: 118-355
Range on HMM: 3-238/239.0
ARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNR-KYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQ
|..  |  |||. ||. ||..|| |.    .  .|||||||. | .|.   |||||| .  .   || |.|. .   |||.| |.|| | || .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

KphLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDGAltGPIIVHCSAGIGRTGTFIAADML
    . |. |||  ..    .| ||... . |   |  | .|..  | |.|||  .. .. |  ..   |   ||   | ..|||||.||||.|.  | .
s..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pga..rpwvihcsagvgrtgaflvidam

MNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.   ..  .   .||   |  .||.|  .|||  ||...|  .|
lrqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 119-355 2.2e-47 156.2 In-house 3-237 (239) alignment 
Range on Protein: 119-355
Range on HMM: 3-237/239.0
RNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNR-KYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
..  |  |||. ||. ||..|| |.    .  .|||||||. | .|.   |||||| .  .   || |.|. .   |||.| |.|| | || .|||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

phLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDGAltGPIIVHCSAGIGRTGTFIAADMLM
   . |. |||  ..    .| ||... . |   |  | .|..  | |.|||  .. .. |  ..   |   ||   | ..|||||.||||.|.  | ..
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pga..rpwvihcsagvgrtgaflvidaml

NAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
   ..  .   .||   |  .||.|  .|||  ||...|  .|
rqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 83-357 2.5e-47 155.9 In-house 13-282 (290) alignment 
Range on Protein: 83-357
Range on HMM: 13-282/290.0
MFAQHVAKMSARNNDGFSDEYNS-L----PAMEKIRAVtVARNArNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADdqGNRKYIATQGPLPNTID
 | .  ...  .| |... ||   |    |.    | .   .|. .  |||....   |  || ||     ||. | |.     .  .| |||.| .|. 
afekfasdvvkknvdelakeyleklkpylpvqylerki.fdknt.efkknrykdvvcndktrvilkdGydGdyvhanyvkG..lkamfiltqGalkdtvi

HFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPH-LHGNVTVTLVGSKQTE-HFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVAL
 .| || ..|...|||.  |.| ||.|||.|.|  .      |..||.   ... . . |..|| .   ..| |  . |..  .| |. |. ||  |. .
diwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

LYQVKMTSqedgaltGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
|. .. .|       ||..|||||||||||||.| ..   ..|  .    .|....|  ||. | . ||   ||. | .|.| |
lrilrkas.......GpvvvhcsaGiGrtGtfvaiev...glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0051429 (Phosphotyrosine protein) phosphatases II 148-358 4.4e-47 156.3 In-house 4-225 (272) alignment 
Range on Protein: 148-358
Range on HMM: 4-225/272.0
NDYINASYIADDQG---NRKYIATQGPLPNTIDHFWEMvWETKASTIVMMTALVEGGKTKCEHYWP-----------TGQKPHLHGNVTVTLVGSKQTEH
..||||...    .    .......||||.|...|| . .| . .|||... ..| |. ||. |||           ..  ..|.|...|||.  .....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FIQRTLLIG---KKGTELTVTHYQYLAWTDHGVPASTapLVALLYQVKMtsqedgalTGPIIVHCSAGIGRTGTFIAADMLMnaiQRSTATDYID-----
.| |.||.    . |. ..|.|..|..| ||||| ..  |..|| ..           ||..||||||..||||..|...|.   .. .... .|     
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYllt

---IAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
   ....|..||.||   |||  ||..|....| |.
nlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 117-357 1e-43 144.2 In-house 44-288 (305) alignment 
Range on Protein: 117-357
Range on HMM: 44-288/305.0
VARN-----ARNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADD-QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP
|| |       .  |||....   | . |.|.     ||| | |.      ....|..|||| .|||.|| || . |   |||.   || || || .|||
vafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

T--GQKPHLHGNVTVT-LVGSKQTE--HFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKmtsqedGAlTGPIIVHCSAGIGRTG
.  |.| .|.. . |  . |||  |    || |||      . ...| | |.  | | |||      . ||  ..      |.   ||.|||||||||||
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gs.kvpivvhcsagigrtg

TFIAADMLMNAIQRSTATDyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
| .| . ... |          .   |  ||.||.  .|.  ||...||.||  
tivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlny
0036282 (Phosphotyrosine protein) phosphatases II 147-352 3.4e-43 142.7 In-house 1-164 (174) alignment 
Range on Protein: 147-352
Range on HMM: 1-164/174.0
GNDYINASYIADDQGNRKYIATQGPLPntidhFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgqkphlhgnvtvtlvgskqtehfiqrtlliGKKGT
|.||||||..     ....||.||||.     ||||..| . .|.||.. ..| |..|| .|||.                               ..  
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

ELTVTHYQYLAWTDHGVPASTApLVALLYQVKMTSQEdgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQrstaTDYIDIAGTVAKLREQRTSLVQTLYQ
| .. .|.|| | ||||| ..  |  .. .|.   .|     ||..||||||.|||||..||....  .     ....|.  .|..|| ||   |||  |
erlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQ

YIYLHR
|..|. 
yrflyy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 101-354 7.9e-43 141.4 In-house 10-255 (267) alignment 
Range on Protein: 101-354
Range on HMM: 10-255/267.0
DEYNSLPAMEKIRAV-TVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVE
 |.. .  . ....  .      |...||. . |||| .|| |. .  ..||||||.   . ....|.||.|| ||| .|.... . | ..||..|   .
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

GgktKCEHYWPTG-QKPHLHGNVTVTLVGSKQTEHFIQRTLL-IGKKGTELTVTHYQYLAWTdhgVPASTAPLVALLYQVKMTSQEDGAlTGPIIVHCSA
.   .   .||    . . . ..||     |. . .   ||    |. .   || | |  |    . .   | .  |. .    | . .   |..|.||.
d...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwn...intnnkpylkplfgilaknqleng.nrPlvvacsd

GIGRTGTFIAADMLmnaIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
|.||.|||. .|     ..|    .  ||   . |.|.|| .||.|. .|||.|...
GvGrsGtflvidsq...leraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 96-355 8.2e-43 141.5 In-house 18-268 (288) alignment 
Range on Protein: 96-355
Range on HMM: 18-268/288.0
NDGFSDEYNSLPAMEKIRAVTVarNARNDDKNRFRNILPYDYNRVQLKgEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
 .|   ||.  |    |.....     |  ..|..|.   |. ||.|. .  . ||.|  ..  . .|. | .| ||  ||. .|.|. |.    |||..
veglkkeyrdspneasidiids..fianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

ALVEGGKTKCEHYWPT--GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG-KKGTELT-VTHYQYLAWTDHGVPASTAPLVALLYQVkmtsqedGALTGPI
 |.| || | ..|.|.  |.| ..  . ||. .  .. .. .. .||   |.| |   | .  .| | |.||| .  . . ||  .        .|. ||
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPi

IVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.||.|||.|||||.|   .   |..    .|.. |   .|||||.|   .||  ||.|.||..|
vvhssaGvGrtgtlilili...aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
0046846 (Phosphotyrosine protein) phosphatases II 145-357 1e-42 141.2 In-house 9-172 (176) alignment 
Range on Protein: 145-357
Range on HMM: 9-172/176.0
EVGNDYINASYIADDqgnrKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLhgnvtvtlvgskqtehfiqrtlligkk
. . |||||..|. .    ..||||||||.|. .|.||..| . ...|..| .|| |. || .|||  .|...                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

gteltvtHYQYLAWTDHGVPAStAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADMLMNaiqrstaTDYIDIAGTVAKLREQRT-SLVQT
       .|..| | ||||| . . |  || ...   .|.    ||..||||||||||||..||..|.           ...  ..|..||||    |||
.......qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqt

LYQYIYLHRIMLSL
  || .|.. .| |
peQyrflyefelll
subfamily_ptpA1_pd Subfamily ptpA1 121-316 1.5e-42 140.8 In-house 45-257 (418) alignment 
Range on Protein: 121-316
Range on HMM: 45-257/418.0
ARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIaDDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPT---GQK
 .|  |||. |||| .. |||||    . |.||||| || |    ...|.|||||||||  || |||| ..  |||..   |  . ||..|||    |..
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

PHL-------HGNVTVTLVGSKQT--EHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQ---EDGALTGPIIVHCSAGIGRT
  .        |  .| ||   |      | | . .  .|    .|.|||  | || .|  | |.  ||. .    .          |||||||||.|||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFIAADMLMNAIQ
||| .| ..|. ..
gtfctavimmkkld
0043147 (Phosphotyrosine protein) phosphatases II 147-351 2.2e-41 136.8 In-house 4-154 (172) alignment 
Range on Protein: 147-351
Range on HMM: 4-154/172.0
GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALveggktkcehywptgqkphlhgnvtvtlvgskqtehfiqrtlLIGKKGT
|.|||||||.      ...|||||||.||...||.|..| . ..||..| |                                          |  ... 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

ELTVTHYQYLAWTDHGVPaSTAPLVALLYQVKMTSQED-GaltGPIIVHCSAGIGRTGTFIAADMLMnaiqrstatDYIDIAGTVAKLREQRTSLVQTLY
| .. .|.|| | ||||| ... |  .| ...   ... |   ||..||||||.|||||..||....           ...  .|| .||.|   ||.  
erlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnps

QYIYLH
||..|.
qyrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 96-356 1e-40 134.2 In-house 10-267 (281) alignment 
Range on Protein: 96-356
Range on HMM: 10-267/281.0
NDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV----GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTI
 | | .|.  ||       .||  .  |. |||. ||   |  ||||| ..      ||| | ||     .| || ||||  .|   || |.|. ....|
lddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMMTALVEGGKTKCEHYWPTGQKPHLH-GNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSqedgaltGP
||.  ..|  . ||  |.|   .  |.  ...|.   |   . ..   | .  .|    .||. .  | |  || |.  .. .| ...  |        |
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.......tp

IIVHCSAGIGRTGTFIAADMLMNAIQRStaTDYIDIAGTVAKLRE-QRTSLVQTLYQYIYLHRIMLS
 ..|||||.||.||..| .. ...|.        ||   |..||   |.. |||| ||. . ...| 
pvihcsagvgrsgtlmaveialqsihsh..ftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0049772 (Phosphotyrosine protein) phosphatases II 116-358 1e-40 135.8 In-house 39-280 (314) alignment 
Range on Protein: 116-358
Range on HMM: 39-280/314.0
TVARNARNDDKNRFRNILPYDyNRVQLKG--EVGNDYINASYIaddQGNRKYIATQGPLPNTIDHF----------WEMV--WETKASTIVM--------
.||.  .| ||||. .|||.| |||.|.|    | |||||||.    | .|.|||||||..|.. |          |.||  .. .  .|||        
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyv...dgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------MTALVEGGktkceHYWPTGQKPHLHgnvtvtlvgskqteH-------FiqrtlligkkgtELTVTHYQYLAWTDHGVPaSTAPLVAL
              . | ..|      ...    ..|.                      |            | .. .| .. ..|...| ... . ..
elsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf............erlgikylripvpDgsap.lledfdef

LYQVKMTsqedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQrstatdyIDIAGTVAKLREQRT-----SLVQTLYQYIYLHRIMLSLI
|  ..          ||..|||.||.||||||..|..|| . .       .... ... .|..|.     .....| ||.. ....| ..
lefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRpinpnpgfieqleqyefilealleyl
0049260 (Phosphotyrosine protein) phosphatases II 161-351 1.1e-39 130.9 In-house 7-143 (152) alignment 
Range on Protein: 161-351
Range on HMM: 7-143/152.0
GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWptgqkphlhgnvtvtlvgskqtehfiqrtlligkkgteltvtHYQYLAWTD
 ....||||||.|||...||.|..| ...||||.| |.| || |||.|.                                          .|..| | |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpD

HGVPASTAPLVALLYQVKMTSQEDGaltGPIIVHCSAGIGRTGTFIAADMLMnaiqrstatDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
|||| ..  |  ||  ..   ...|   ||..||||||.|||||..||....           ...  .|| .||.|   |..  |...|.
hgvpdlsqlllflllfieklaldkg...gpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 123-350 9.4e-38 124.6 In-house 50-273 (301) alignment 
Range on Protein: 123-350
Range on HMM: 50-273/301.0
NDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLH-GNV
..||.|. ..       |..  .     | | .|  .   ...|||||||.|| . || |.   .  .|||..  ||  ..|||.| |.  . .|. |  
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

TVTLVGSKQ--TEHFIQRTLLIGKKGT---ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMNAIQ
..... ...   .. ..||| .          |||||||  |||.||| | | |  |.  || . .       ||.|||||||||. .||....| ....
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylareve

rstATDYIDIAGTVAKLREQRTSLVQTLYQYIYL
   |   |... ....|||.| . |||  |  ..
...adptieltealkhlrehrwngvqtnsqlywm
PTPc_DSPc_SM00012 249-355 1.4e-33 110.6 In-house 1-104 (105) alignment 
Range on Protein: 249-355
Range on HMM: 1-104/105.0
TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGAlTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatDYIDIAGTVAKLREQRTSLVQTLYQYI
||.||.|..|.||||| .. ... || .||   .. .  ..|..||||||.||||||.|.|.|.. ....|  . .||  .| .||.|| ..|||..||.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqyl

YLHRIML
.|.|..|
flyrall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 123-357 4.9e-33 109.1 In-house 43-275 (312) alignment 
Range on Protein: 123-357
Range on HMM: 43-275/312.0
NDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTG-------QKP
  | ||. ||  .|  |  | |.  | || | ..       ....||||| ||. |||...    ...|......|| |  || .|           .. 
fkdlnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

HLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMN
     .|   .| |  ..  .| | .     | |  . |||. .| |||.| |      ||  ||   .       |.| |||||.|||||..  . .. 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmia

AIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIMLSL
|..     .  |.      || .|.  |... ||.|  |..| .
alrhprkqnvkds...fvllrkdrarsvrvfpqyvyalrcvlef
subfamily_CG42327_pd Subfamily CG42327 100-280 7.2e-33 108.6 In-house 8-193 (319) alignment 
Range on Protein: 100-280
Range on HMM: 8-193/319.0
SDEYNSLPameKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIA-DDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
 .|.. ||   .. | . .  .  .||.|. |..|    || |.       . |..|||.   |. .  |||.| .| ..   || .||| .. .|| .|
aeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ALVEGGKTKCEHYWPT---GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTEL--TVTHYQYlAWTDHGVPASTAPLVALLYQVKMT
 | | |  .| .|.||   ..  .|.|.. ||| | .  ....  |||. .   |.   .||| |  | . .|||. |.|.|.| .|. .
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 97-357 1.4e-32 107.5 In-house 27-289 (310) alignment 
Range on Protein: 97-357
Range on HMM: 27-289/310.0
DGFSDEYNSLPAMEKiRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV--GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMM
.|.  .|  | | .   ..|     ..  |||. ...  |  ||.|| .    .||| | |.  .     .| .||||  ||  || |... .| .|...
eglvkqyrkldakqd.ssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEH--------FIQRTLLIGKKG---TELTVTHYQYLAWTDHGVPASTAPLVA--LLYQVKmts
   .| |. ||  |||.      .| . || ..    |         |.   . . ..     || |.  ..  | | |||      |   || ||.   
ckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr...

qedgalTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
       || .||||||..|... .| ..   .|...   ...|.   ...|. .|.  .||  ||....|... .
......hgpcvvhcsagkdrlyvvvalkl...kidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 119-355 2.7e-32 106.9 In-house 31-267 (285) alignment 
Range on Protein: 119-355
Range on HMM: 31-267/285.0
RNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIAD-DQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPH-
    | | ||. ..   .  || ||     ||| ||..    . .  ||.||||||.|.  || |... | . ..|. .|.|||  ||  |.|       
ayeanpdlnryadvrcieetrvvlknh.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LHGNVTVTLVGSKQT--EHFIQRTLLIGK----KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADM
  |.  .||   |.      |  .| . .        | . | |   | |.  |  . |.. |   ||    ..     || ||||||.||| ||.  | 
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke....kpicvhcsagvgrtatfvgidy

LMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIML
    |      . .||   | ..|  |   ||.  |...|. ...
atirimenpniemldi...vremramrfqavqshmqflflyvvlm
0044763 (Phosphotyrosine protein) phosphatases II 140-356 2.9e-32 107.1 In-house 10-169 (178) alignment 
Range on Protein: 140-356
Range on HMM: 10-169/178.0
VQLKGEVGNDYINASYIADDqgnrKYIATQGPlpntiDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKphlhgnvtvtlvgskqtehfiqrtl
  | |. . ||||||.| ..     |.....|      ...|...| . ..||..|  .|.|. || .|||..                           
snleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.........................

ligkkgteltvTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGaltGPIIVHCSAGIGRTGTFIAADMLMNAiqrstatdYIDIAGTVAKLREQRTs
            .|... . ||||| ... . ...  ..   .|.|   ||..||||||.||.||..||....           ...   .. .||.|  
...........iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvrerRp.

LVQTLYQYIYLHRIMLS
 |..  |. .|... | 
ivpnpgqlrqLyefelr
0051082 (Phosphotyrosine protein) phosphatases II 148-353 4.6e-32 106.1 In-house 3-148 (151) alignment 
Range on Protein: 148-353
Range on HMM: 3-148/151.0
NDYINASYIADDqgnrkYIATQGPLPntidHFWEMVWETKASTIVMMTALVEGGktKCEHYWPTGQkphlhgnvtvtlvgskqtehfiqrtlligkkgte
.||||.||. .      .....|||.    .|.|...| . .|||... ..| |  .| .|.|  .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

LTVTHYQYLAWTDHGVPASTAPLVALLYQVKMtsqedgaL-TGPIIVHCSAGIGRTGTFIAADMLMNAiqrstatdyIDIAGTVAKLREQRTSLVQTLYQ
..|.|...| |.|.|.| |.. ....| ..            ||..||||||.|||||..|.....           .... ... .|..|. .||.  |
ievlhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqq

YIYLHRI
...... 
flfqlfa
subfamily_egg_pd Subfamily egg 114-356 2.3e-31 103.6 In-house 31-268 (307) alignment 
Range on Protein: 114-356
Range on HMM: 31-268/307.0
AVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGgkTKCEHYWP
..| | .. | .| | . .   |. ||.|   .|   .|.| | ..  .    ..| .| || || | || ||.. .   |||.|. .|    .||.|||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

TGQKPHL-H--GNVTVTLVGSKQTEH--F-IQRTLLIGKKGTELTVTHYQYlAWTDHGvpASTAPLVaLLYQVKMTSQedgaltgPIIVHCSAGIGRTGT
  ..  |    |.. .. .. ...    | . .  |.| .  |. . |.|.  .   .      ||  .| ...  |.       |..|..  |. ...|
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss..dvysplr.vlrklrnlsk.......pvvvqdilGvskaat

FIAADMLMNAIQRSTATDYIdIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
..|... .  . |   | .. .  .|  || .|   |..  .|....|..| 
lvaieiallsllrGpitksl.vlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 112-218 1.4e-26 88.1 In-house 36-159 (350) alignment 
Range on Protein: 112-218
Range on HMM: 36-159/350.0
IRAVTVARNARNDDKNRFRNILPYDYNRVQLK-----------GEVGNDYINASYIADD------QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMM
.  | ..   .   |||..|||||. .||.||              .||||||.|.         . . ||||||.|||.|.| |.... . |   |...
snDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

TALVEGGKTKCEHYWPTGQKPHLH
|..|| .  ||..||. |.    .
tsdvelnlekcyrYWqegsyddit
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 167-350 3.9e-26 86.7 In-house 39-213 (255) alignment 
Range on Protein: 167-350
Range on HMM: 39-213/255.0
AtqgplpnTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQ--KPHLHG-NVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGV
        |.|.|....  ||....||.. . | |. ||..|.|. .  |  |.  |||.|   ..   . .. |. .|.|    ||.||.|  | ..  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PASTAPLVALLyQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMNAIQ---RSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYL
|  .  .  .| .|   |.       ...||||.||||. .|. |...   .    . | |  .|    . .||..|.. ..|  |  . 
Pelareilnil.kvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 160-351 2.1e-25 84.0 In-house 2-197 (199) alignment 
Range on Protein: 160-351
Range on HMM: 2-197/199.0
QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE----LTVTHYQ
.|.|.||||| || .|.  ||.||||| .  |||.       ..    |||| .     .|...||         .   .|.. .. |       ..|||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YLAWTDHGVPAStAPLVALLYQVKMTS-QEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStATDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
. .| ..  |   | .| ..   .  | . .     |.||||| | | || |.| |. . . . |  |  .|.     .||. |  .. .| .| ...
ftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 161-351 3e-25 83.6 In-house 2-196 (198) alignment 
Range on Protein: 161-351
Range on HMM: 2-196/198.0
GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE----LTVTHYQY
|.|.||||| || .|.  ||.||||| .  |||.       ..    |||| .     .|...||         .   .|.. .. |       ..|||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

LAWTDHGVPAStAPLVALLYQVKMTS-QEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStATDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
 .| ..  |   | .| ..   .  | . .     |.||||| | | || |.| |. . . . |  |  .|.     .||. |  .. .| .| ...
tswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 138-355 8.4e-25 82.5 In-house 33-257 (290) alignment 
Range on Protein: 138-355
Range on HMM: 33-257/290.0
NRVQLKG---EVGNDYINASYIADDQGnRKYIATQGPLPNT-------IDHFWEMVWETKASTIVMMTALVEGGKT----KCEHYWPTGQKPHLH-GNVT
.|| |||      .||| |...   .|  . |.|| |. ..       | .|| |. . |.  .||.    |  .      |..| |.    .|  ...|
trvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VTLVGSKQTEHFIQRTLLIG-KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKmTSqedgalTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStaT
|      . . ...|.|..   .. |.||||...  |..  |. .|  |..|. .|| .|      . |.||||  || |  .. | .. .  |  .  .
vkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as......ktpvivHcvdGiSrsAalaaiilgyQkiaet..s

DYIDIAGTVAKLREQRTSLVQTLYQYIYLH-RIML
. . ..  . .||.||  ....  .. .    |.|
gsvkledvlkalrkqralaitsalelafvdagivl
0048076 (Phosphotyrosine protein) phosphatases II 240-355 2.6e-23 77.7 In-house 37-140 (145) alignment 
Range on Protein: 240-355
Range on HMM: 37-140/145.0
LIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADMLMNaiqrstatDYIDIAGTVAKLREQRTS
   ... | ....|.|| | ||||| ... | ..| ...   .|.    ||..||||||.|||||..||....           ...  .....|.||  
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsqrpg

LVQTLYQYIYLHRIML
 |..  |...|..  |
avpnpgqlrflyefel
subfamily_hpo-7_pd Subfamily hpo-7 169-351 6.5e-23 76.0 In-house 42-220 (263) alignment 
Range on Protein: 169-351
Range on HMM: 42-220/263.0
QgpLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQ--KPHLH-GNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPA
   | .||| |....  ||....||..   | |. ||..|.|. .  |  |.  ||..| | |.   . .. .  .|.| .  ||.||.|  | ..  | 
l..lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpe

STAPLVALLyQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMNAIQ---RSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
 .   . .| .|   |.       ...||||.||||.  |  |...   .    . | |  .|    . .||..|.. ..|  |  .  
lareilnil.kvarnsk.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
0048179 (Phosphotyrosine protein) phosphatases II 241-352 3e-22 74.3 In-house 48-139 (144) alignment 
Range on Protein: 241-352
Range on HMM: 48-139/144.0
IgkkgteltVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADMLMnaiqrstaTDYIDIAGTVAKLREQRTSL
         ...|..| | ||||| ... | ..|  ..   .|.    ||..||||||.|||||..||....        .  ...  ..| .|..|   
e........giqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpga

VQTLYQYIYLHR
|..  |...|..
vpnpgqlrfLle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 100-358 3.2e-21 70.0 In-house 29-285 (302) alignment 
Range on Protein: 100-358
Range on HMM: 29-285/302.0
SDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVgNDYINASYIADDQGNRKYIATQGPLPNTI---DHFWEMVWETKASTIVMMTA
 .|.... .| |. .       .| .||.  ..  .| |.|.|..|  ..|.||| .   . .|. | .| |  ..    ..|| ||.. |  ..|..  
kkefkkidtm.kvdlekCkafkknlkknqsedvpildsnlvkleaep.dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg

LVEGGKtKCEHYWPTGQ-KPHLHGNVTV--TLVGSKQTEHfIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVkMTSQEDGalTGPI
  |  |   ....|. . . . .|.. |    | ... |.  . .. .  .|    . .. |    | .. || . | |..   .|  ......  . ..
eeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkika..dent

IVHCSAGIGRTGTFIAADMLMNAIQRSTATdyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
..    |.|| |.|... . .. .|.. .     |. .|...|.||.. |..| ||. |....| .|
vivSknGaGRagafltlavaveklqkgkep...nikeivksiRsqRpravdslkQyvslyialllyi
subfamily_eak_pd Subfamily eak 111-267 3.5e-20 66.7 In-house 40-198 (332) alignment 
Range on Protein: 111-267
Range on HMM: 40-198/332.0
KIRAVTVARNARNDDKNrFRNILPYDYNRVQLKGEVGN--DYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHY
.........   . ..|   .|.|||.. |.|     |   ||||| .   .  |||| |  .  . .  ||.|| | |. .||..   || .  | . |
rllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPTGQ-KPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPAST
.|    .   .| . |.     . . .  | | . |      | ||..  ||.  .|   
fpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 249-355 1.7e-19 64.5 In-house 90-191 (440) alignment 
Range on Protein: 249-355
Range on HMM: 90-191/440.0
TVTHYQYLAWTDHGVPASTAPLVALLYQVKmTSQEDgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYI
|. .|.| .| |.|||  ..|.. .. .|.  |||  |  ||..|||||| ||||  || | ..   .||   | |||   .  .|..|  .|||  || 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvn.esqek.agngpllvhcsagagrtgviiavdsilreakrs...dqidifsfinsmrnnrpqmvqtpeqya

YLHRIML
..|  .|
fvheavl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 115-353 7.1e-18 59.2 In-house 39-274 (303) alignment 
Range on Protein: 115-353
Range on HMM: 39-274/303.0
VTVARNARNDDKNRFRNILPYDYNRVQLKGevgNDYINASYIADDqGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
|.  .  .| ||||| ...  |. .|.|       || |||.  |  ..| | || ||. |   ||.|. | |   .... .  |  |   .  .|  | 
vsknqfvknmdknrfvdvicldhskvklsd...ssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

PHLHGNVTVTLVGSKQTEHFIQRTL--LIGKKGTELTVTH-YQYLAWTDHGVPASTA-PLVALLYQVKMTSQEDGALTGPIiVHCSAGIGRTGTFIAADM
     . .. .   |. |     .|  |   .|.  .  | ..| ||    .|. ..  .|  ..|..   .     | ..     .| ||.|||   . 
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptv.ymslsgcgragtfalfet

LMNAIQRSTATdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRI
   ...   |.  .|.   . ..|. |   || | |. ... .
ahlslhseqas..ldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 247-355 3e-17 57.4 In-house 214-341 (350) alignment 
Range on Protein: 247-355
Range on HMM: 214-341/350.0
ELTVTHYQYLAWTDHGV---PASTAPLVA----LLYQVKMTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMN-------AIQRSTATDYI----D-IA
 . | . |.  | | ..   | |  . .     |. .    |  | | . ||.||||||.|||||... |.|..         ..|.  |.     | | 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

GTVAKLREQRTSLVQTLYQYIYLHRIML
 .| .||.|| |.||.| |.|...  .|
iivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 117-228 1.9e-16 54.4 In-house 90-198 (244) alignment 
Range on Protein: 117-228
Range on HMM: 90-198/244.0
VARNARNDDKNRFRNILPYDYNRVQL-KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEggktkCEHYWPTGQKP
 | |  |  |||    ||.|.||| | || .|| |||||..       .|| || || .|   || |. | .   .|.. .. |      . |||  .  
dafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdsepl

-HLHGNVTVTLVGS
     ..||||   
ewyeeditvtltdr
subfamily_CG42327_pd Subfamily CG42327 288-354 2.1e-16 54.5 In-house 247-311 (319) alignment 
Range on Protein: 288-354
Range on HMM: 247-311/319.0
TGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
 ||..|||| |.||||. ||.|. .. .. |  .  .||  .|  .|..|.| |.|  || ......
qGPlvvhcsdGvGrtGlviasdiairsleeskrs..vdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 174-351 9.1e-16 52.2 In-house 102-281 (302) alignment 
Range on Protein: 174-351
Range on HMM: 102-281/302.0
NTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLH-GNVTVTLVGSK-QTEHFIQR------TLLI----GKKGTELTVTHYQYLAWTDH
.|.. .| .. . . . .| ....||... || .|. .  . .|. |. ||. |  | . |.|  .      |. |     || .. ||   .. || ||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPASTAPLVALLYQVKmtsqedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLH
| |. . . . .|   .       .    ..||||||.|||||..|    ..  ..   || ..|   |  .|. |   ||.  | ||| 
Gapkeaytaldilkfce.......sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi...vlpvrqcryGavqdeqqliyll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 110-214 6.3e-15 49.3 In-house 35-158 (349) alignment 
Range on Protein: 110-214
Range on HMM: 35-158/349.0
EKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK-----------------GEVGNDYINASYIADDQ--GNRKYIATQGPLPNTIDHFWEMVWETKAST
 .|  | ..   .   |||...||||.. ||.||                 . . .||||| |.   .   ..|||||| ||| |.| |....   .   
seiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvkl

IVMMTALVEGGKTKCEHYWPTGQK
.. ..   | .  ||. ||  .. 
vlsLnddkelslekcdiywqelsy
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 79-170 1.1e-14 48.3 In-house 5-95 (95) alignment 
Range on Protein: 79-170
Range on HMM: 5-95/95.0
SKKIMFAQHVAKMSARNNDGFSDEYNSLPaMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADDQGNRKYIATQG
 .  .|  || .| .  .. | .|..|.. |    . ||     |  |||| ||.|||  || |      ||||| ..     .  |||.||
ihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 126-194 1.6e-11 38.4 In-house 40-116 (347) alignment 
Range on Protein: 126-194
Range on HMM: 40-116/347.0
KN---------RFRNILPYDYNRvQLKGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMM
||           | .|  .  . . . .  . |||||.|  |. ...|| || |||.|.  || ||  || . .| .
knrskdvklidatrvvlspeksk.nsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 133-260 1.7e-11 38.6 In-house 3-123 (130) alignment 
Range on Protein: 133-260
Range on HMM: 3-123/130.0
LPYDYNRVQlkgevGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEggktkCEHYWPTGQKPH-LHGNVTVTLVGSKQT
|.....|.|     ||.|||||..   .  ..|. || || .|  .|| |. |     .|.. .. |      . |||  .  .    ...|||   .. 
lefevsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdef

eHFIQRTLLIG-KKGTE--LTVTHYQYLAWTD
 ..|. . | . ..  |   ..| .|   |  
.knikasnleiesdlneshqaltmfqisnwps
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 284-356 5.3e-11 36.4 In-house 261-342 (349) alignment 
Range on Protein: 284-356
Range on HMM: 261-342/349.0
DGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQ----RSTATDYI-----DIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
| . . ...|||||| ||||...  |.|.. ..     |   ..       |  .| .|| || |.|| | |.| ..  .| 
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 164-241 2.4e-10 34.3 In-house 237-311 (440) alignment 
Range on Protein: 164-241
Range on HMM: 237-311/440.0
KYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEggKTkCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLI
 .|||| ||  |.  || .| . . |||.|.  | .  || |  |||   .    |  ||   ||.. .    ||| .
afiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 292-354 3.4e-10 34.2 In-house 2-61 (69) alignment 
Range on Protein: 292-354
Range on HMM: 2-61/69.0
IVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
.||||.| ||||||||  . |    |  .   .||   |  .|  |  .|    .||..|  .
vvhcssgtgrtgtfiaimvema...rikseklvdifnnvqymrkcrpmmvmneieyifihdal
0038934 (Phosphotyrosine protein) phosphatases II 251-312 1.4e-09 33.4 In-house 80-139 (194) alignment 
Range on Protein: 251-312
Range on HMM: 80-139/194.0
THYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMLM
 .|  | . |.|.. |.. |   |  |.   .||    | . ||| ||.|||||..|| ...
ieylklpfpddgtvPsleillrfldlvdeflnedp..ggvvaVHCkaGlgRtGtlvaaYLiy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 292-353 1.6e-09 32.0 In-house 1-59 (69) alignment 
Range on Protein: 292-353
Range on HMM: 1-59/69.0
IVHCSAGIGRTGTFIAadmLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRI
.||||.| ||||||||   .|  . |  .   .||   |  .|  |  .|    .|...|  
vvhcssGtGrtGtfia...imvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_PTPDC1_pd Subfamily PTPDC1 250-350 2e-09 32.2 In-house 83-168 (182) alignment 
Range on Protein: 250-350
Range on HMM: 83-168/182.0
VTHYQYlAWTDHGVPASTaplvALLYQVKMTSQedGALTGPIIVHCSAGIGRTGTFIAADMLMNaiQRSTATDyidiagTVAKLREQRTSLVQTLYQYIY
...|.. .|.|.||.. .     .|  ||. ..      | . ||| || ||||  ||. .. .  .| || .      .. ..|..|.. .||  |   
iyvynf.gwkDygvasle....riLdivkvvaf..alqegkvavhChaGlGrtGvliacylvya..krltaek......aiklvrskrpksiqtreqvel

L
.
v
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 82-157 2.9e-09 30.7 In-house 9-84 (440) alignment 
Range on Protein: 82-157
Range on HMM: 9-84/440.0
IMFAQHVAkmSARNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIA
  ||..|   . |    | ||.. ||.    .   .|    |  |||.|||| ||..|| |   ||   .||||||||.
adfadyvq..nnrrsrafedewsllpsg.lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 119-205 1.1e-08 29.0 In-house 30-118 (332) alignment 
Range on Protein: 119-205
Range on HMM: 30-118/332.0
RNARNDDKNRFRNILPYDYNRVQLKGEVGN-DYINASYIADDQGNRKYIATQGPLPNTID-HFWEMVWETKASTIVMMTALVEGGKTKC
.   | | ||   .  .|..||.|  . |. |. |||..     .  || .| |. .  .  || || | | | |...  . |  | |.
kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 117-223 2.8e-08 26.9 In-house 21-98 (169) alignment 
Range on Protein: 117-223
Range on HMM: 21-98/169.0
VARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINAsyiaddqgnrkyiatqgplpntidhfwEMVWETKASTIVMMtalveGGKTKCEHYWPTGQ
.|  . |. |||    |   . ||.|.    ..|.|||||                           .|.||| || ||..     |.    . .||  .
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpeke

KPHLHGNVTV
   ||  | .
dyqlhpavil
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 117-223 3.5e-08 26.5 In-house 20-97 (169) alignment 
Range on Protein: 117-223
Range on HMM: 20-97/169.0
VARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINAsyiaddqgnrkyiatqgplpntidhfwEMVWETKASTIVMMtalveGGKTKCEHYWPTGQ
.|  . |. |||    |   . ||.|.    ..|.|||||                           .|.||| || ||..     |.    . .||  .
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpeke

KPHLHGNVTV
   ||  | .
dyqlhpavil
PTEN_1 258-326 1.3e-07 26.6 In-house 102-166 (196) alignment 
Range on Protein: 258-326
Range on HMM: 102-166/196.0
WTDHGVPaSTAPLVALLYQVKMTSQEDGAlTGPIIVHCSAGIGRTGTFIAAdMLMNAIQrSTATDYIDI
..|||.| | . | . .....   ..|    . ..||| ||.||.|| .||  || . . .|| . ...
ieDhgap.slselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeAlel
subfamily_CDKN3_pd Subfamily CDKN3 247-352 1.9e-07 24.8 In-house 99-190 (202) alignment 
Range on Protein: 247-352
Range on HMM: 99-190/202.0
ELTVTHYQYlawTDHGVPaSTAPLVALLYQVKMTSQEdGALTgpiIVHCSAGIGRTGTFIAADMLMnaiqrstATDYIDIAGTVAKLREQRTS-LVQTLY
 |.| || .   .| .|| . |  . .| ..... .. .  |   .|||  |.||.   ||  .|.         |.|.   ...|||. . |  .||. 
glivhhypi...adglvp.diasclkileelrinlka.yrkt...lvhcygglgrsslviacllly.......lddtiepkdaidklrdlkgsraiqtvk

QYIYLHR
|| ||. 
qynylse
subfamily_CDC14_pd Subfamily CDC14 287-313 2.2e-07 25.0 In-house 262-288 (328) alignment 
Range on Protein: 287-313
Range on HMM: 262-288/328.0
LTGPIIVHCSAGIGRTGTFIAADMLMN
 .| |.||| ||.|||||.||. .. .
aeGaiavhCkaGLGrtGtLiacylmkh
PTPc_motif_SM00404 269-320 2.2e-06 22.6 In-house 61-111 (140) alignment 
Range on Protein: 269-320
Range on HMM: 61-111/140.0
PLVALLYQVKMTSQEDGALTGPIIVHCSAGIGRTGTFIAAdMLMNAIQRSTA
.|.. | .|.   ..  .  | ..||| ||. |..|.|.|  ||.  | |.|
klskyldkvldfienaekkggkvlVHCqaGvSRSatliia.Ylmryrqlsla
0048567 (Phosphotyrosine protein) phosphatases II 258-312 2.6e-06 21.9 In-house 45-101 (157) alignment 
Range on Protein: 258-312
Range on HMM: 45-101/157.0
WTDHGvPASTAPLVALLYQVKMTSQEDGALTGPIIVHCSAGI---GRTGTFIAADMLM
. |.| | . | |. . ....   .      ..|.|||.||    |||.|.|.. ...
ffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil
DSPc Dual specificity phosphatase, catalytic domain 284-324 3.4e-06 22.0 Pfam-A 69-110 (133) alignment 
Range on Protein: 284-324
Range on HMM: 69-110/133.0
DGALTGPIIVHCSAGIGRTGTFIAADMLMN-AIQRSTATDYI
  .  . ..||| ||| |..|.|.| ...   .. . | ...
aeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv
DSPc Dual specificity phosphatase, catalytic domain 284-324 3.4e-06 22.0 In-house 69-110 (133) alignment 
Range on Protein: 284-324
Range on HMM: 69-110/133.0
DGALTGPIIVHCSAGIGRTGTFIAADMLMN-AIQRSTATDYI
  .  . ..||| ||| |..|.|.| ...   .. . | ...
aeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv
subfamily_PTEN_pd Subfamily PTEN 291-327 3.7e-06 22.1 In-house 117-152 (184) alignment 
Range on Protein: 291-327
Range on HMM: 117-152/184.0
IIVHCSAGIGRTGTFIAAdMLMNAIQRSTATDYIDIA
..||| || ||||. |.|  |... . ..|.. ... 
vvvHCkaGkGRtGvliva.yllkslllekaeealelf