Gene INPP5 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP119_AA protein Get Run
SpurP119_AA_226-553 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 48-575 2.6e-201 662.2 In-house 3-525 (951) alignment 
Range on Protein: 48-575
Range on HMM: 3-525/951.0
VFGVIGKLRIHPESEWRLLLIRSHRLVGQLPK-----GHDVYCITRIAVLPLSQNGHPDIEIERCDKHHFGIRQKANLILGPAEGQQKSLAKTWNSIKS-
|.|||||.... |.|..|.........|.||.      ..|..|.|.|.|.||.......| |.|......|......|.. .||..|. .|.|..|.. 
vygvigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldlsekdskelekeectgliglielegkiivatiegkskvnnkkwdlidid

----VAQVKKKEVKEREKLERRILEELNRMFTEsDWFYYSPTGDLTNSIQRHHTHKGAGY----DERFFWNQHMLQDILDTQNKELARpWIIPIVQGCVQ
    ... ..||..|.||||.|.||||...... ..||||.. ||||..|...... . .    |||||||...|.|......|. .. ...|..||.|.
ssgylqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldke.fltpviqGfve

IRECRMTfapeegaqsggsgadsddsDIKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQTAEHSVSFVQVRGSVPVFWSQPGIKYKPPPR
..|....                   . |..|.||||||..|||||..|||||..| .||.||||.||.......||.|.||||||||.|.| ||||...
tkeisie...................klkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkkykpkik

IDRDDDESQEAFKTHFEEDLQRYRHVAIISLIEQAGREAIVGSAFMKHVLLYDSPKLTYITFDFHEYCRGLRFDKVSVLLESIRDVIKEMRYCWADAEG-
|.|...|.|.||..||.|.|..|..|.|..|..|...| ....|.....| ..|.....|.|||||...| .|..|| |.|.|.. |||..|.. | .. 
itrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkek

VILEQRGVFRVNCMDCLDRTNVVQTALARVVLRTQLRKLGLLLPEQRLV-PSIKTIYQDMWANNGDIVSRQYAGTAALKGDYTRTGERKLTGLMKDGYNS
|| ||.||||.||.||||||||||.|....||..||.||||. ||...  ..... ....||.|||..|||||||.|||||.||.|||||.|..||||.|
viseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyks

ASRYVQNQLKDAFRQVAIDLMLGNQEIQEDLTLIDEQKASAEMG
.||| .|..||..|| .|||.||... ||. .|||..| . | .
vsryylnnfkdkyrqkvidlllGklpkqevvelidpkkeekeee
subfamily_SAC1_pd Subfamily SAC1 139-558 4.5e-129 422.0 In-house 47-455 (458) alignment 
Range on Protein: 139-558
Range on HMM: 47-455/458.0
IKSVAQVKKKEVKEREKLERRILEELNRMFtESDWFYYSPTGDLTNSIQRHHTH---------KGAGYDERFFWNQHMLQDILDtqnKELARPWIIPIVQ
| .|.. ... ..| .| |.. |. |. .. .|. ||.| | |||||.||..                |||||||.|.|.|. .   .. .. .|.|...
iipvkknslslteeqkkeekeylkllelvl.ksetfYfsytydltnslqrlekvtsaalkerslleradeRffwnkhlledlrk...epelesfilPvik

GCVQIRECRMtfapeegaqsggsG-AdsddsdiKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQTAEHSVSFVQVRGSVPVFWSQPGI-K
| ..|.|. .                       .....|||||| ||||||| .||.|..| .||.||||||... .. .||||||||.|..||| .  |
Gfikikelsl.............nak.......eikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLk

YKPPPRIDrDDDESQEAFKTHFEEDLQRYRHVAIISLIEQAGREAIVGSAFMKHVLLYDSPKLTYITFDFHEYCRGLRFDKVSVLLESIRDVIKEMRYCW
||| ...  . ..|..|||.|..|  ..| .  ...|..| |.|. .|.|. . |  ....|. |..||||. ||  |.|....|......  ... | .
ykPkvkls.esedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyfl

AD-AEGVILEQRGVFRVNCMDCLDRTNVVQTALARVVLRTQLRKLGLLLPEQRLV--PSIKTIYQDMWANNGDIVSRQYAGTAALKGDYTRTGERKLTGL
 . .. .. ||.||.| ||.||||||||||. ||| ||..||..||.|  |..|   ....|.....||.|.| || |||||.||| |.|||| |.|.|.
kseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGa

MKDGYNSASRYVQNQLKDAFRQVAIDLMLGNQEI
..||.||.|||..|. .| .|| .|||.||.  .
lrDgvnsvsryyknnfldgerqdsidLflgkyrv
Sac_COG5329 256-568 6.8e-107 349.9 In-house 218-531 (1070) alignment 
Range on Protein: 256-568
Range on HMM: 218-531/1070.0
SDDSDIKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQTAEHSVSFVQVRGSVPVFWSQ-PGIKYKPPPRIDRDDDESQEAFKTHFEEDLQ
....  .  | ||||||. |||||. .||.|..| .||.||||||...... .||.|||||.|.||.|  .  ..|. .| |.. ..|.||. ||..  .
ikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfe

RYRHVAIISLIEQAGREAIVGSAFMKHVLLYDSPKLTYITFDFHEYCRGLRFDKVSVLLESIRDVIKEMRYCW--ADAEGVILEQRGVFRVNCMDCLDRT
.|  | |. |... ..|. . ... ||. | . ||.....||||  ..  .||.|. ||. |.. ..|. |         .| || ||||.||.||||||
kYGdvhivNLlktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRT

NVVQTALARVVLRTQLRKLGLLLPEQRLvpSIKTIYQDMWANNGDIVSRQYAGTAALKGDYTRTGERKLTGLMKDGYNSASRYVQNQLKDAFRQVAIDLM
||.|. ... ||  |.|...     .    .. .... .||.||| .|..| || |||...||.| | . | ..|  .|.||. .|.  |. .| ||||.
NviQqliskrvlleqfrsikvisaidde..dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidll

LGNQEIQEDLTLIDEQ
||  . ||.. |.|. 
Lgklpdqeavelydpi
Syja_N SacI homology domain 48-407 1.2e-86 281.7 Pfam-A 1-318 (319) alignment 
Range on Protein: 48-407
Range on HMM: 1-318/319.0
VFGVIGKLRIHPesEWRLLLIRSHRLVGQLPKGHDVYCITRIAVLPLSQNGHPDIEIErcdkhhfgirqkanlilgpaegqqKslaktwnsiksvaqvkk
..|..| .|..   |  ||.| . . |... ..|..| |......||... . . .||                        .                 
aygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie........................e.................

kEVKEREKLERRILEELNRMFtESDWFYYSPTGDLTNSIQRHHTHKG-------------AGYDERFFWNQHMLQDILDTQnkELARPWIIPIVQGCVQI
 | .|.|| |...|..|.... .|. ||.| . |||.|.||.....                .||||.||...|..... .    .  |..|..||.|..
.ekeeeekeeekllkllkkll.ssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielk..ldlsrwllpliqGfveq

RECRMTfapeegaqsggsgadsddSDIKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQ-T-A--EHSVSFVQVRGSVPVFWSQ-PGIKYK
|.. .                   |. |..|.||||||. |||||| |||||..| .||.||||||.. . .  .. .||||.|||||.||.| .....|
rsievk..................skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslk

PPPRIDRDDDESQEAFKTHFEEDLQRYRHVAIISLIEQAGREAIVGSAFMKHVLLY-----DSPKLTYITFDFHEYCRGLRFD
|...|.|. ..||.||| ||.. ..||... ...|.|. |||. ...|. ...  .     .. || ||.||||. |.| .|.
pkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 48-407 1.2e-86 281.7 In-house 1-318 (319) alignment 
Range on Protein: 48-407
Range on HMM: 1-318/319.0
VFGVIGKLRIHPesEWRLLLIRSHRLVGQLPKGHDVYCITRIAVLPLSQNGHPDIEIErcdkhhfgirqkanlilgpaegqqKslaktwnsiksvaqvkk
..|..| .|..   |  ||.| . . |... ..|..| |......||... . . .||                        .                 
aygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie........................e.................

kEVKEREKLERRILEELNRMFtESDWFYYSPTGDLTNSIQRHHTHKG-------------AGYDERFFWNQHMLQDILDTQnkELARPWIIPIVQGCVQI
 | .|.|| |...|..|.... .|. ||.| . |||.|.||.....                .||||.||...|..... .    .  |..|..||.|..
.ekeeeekeeekllkllkkll.ssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielk..ldlsrwllpliqGfveq

RECRMTfapeegaqsggsgadsddSDIKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQ-T-A--EHSVSFVQVRGSVPVFWSQ-PGIKYK
|.. .                   |. |..|.||||||. |||||| |||||..| .||.||||||.. . .  .. .||||.|||||.||.| .....|
rsievk..................skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslk

PPPRIDRDDDESQEAFKTHFEEDLQRYRHVAIISLIEQAGREAIVGSAFMKHVLLY-----DSPKLTYITFDFHEYCRGLRFD
|...|.|. ..||.||| ||.. ..||... ...|.|. |||. ...|. ...  .     .. || ||.||||. |.| .|.
pkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
subfamily_Synaptojanin_pd Subfamily Synaptojanin 142-562 2e-82 268.8 In-house 45-441 (754) alignment 
Range on Protein: 142-562
Range on HMM: 45-441/754.0
VAQVKKKEVKEREKLERRILEeLNRMFTeSDWFYYSPTG------DLTNSIQRHHTHKGAgyDERFFWNQHMLQDIldTQNKELARPWIIPIVQGCVQIR
.....  ....  . | || | |..... |. ||.| .       ||. | ||.....    |.|||||. .   .  .. .  .. |..... | |.||
itstelvslrseasdedriie.lkklla.sgtfyfsssadsasrldlslsaqrrkqeese..dnrffWnrslhlhl..qrfgvncddWllkvmcGsveir

ECrmtFApeegaqsggsG-AdsddsdiKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQTAEHSVSFVQVRGSVPVFWSQPGIKYK-PPPR
     .|          |         . . .|||| |  |||||.  ||... |  ||.|||||..   .. .||||.|||||.||.|||..      .
tv...ya..........gak.......qakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvk

IDRDDDESQEAFKTHFEEDLQRYRHVAIISLIEQAGREAIVGSAFMKHVLLYD-SPKLTYITFDFHEYCRGLRFDKVSVLLESIRDV-IKEMRYCWADAE
. |. . |. ||. |.|.  .|| .|.|..|. . . |... .|| ||      .... ...||.|. ..| . .|.. ||. .    .... .  .  .
lsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgk

GVILEQRGVFRVNCMDCLDRTNVVQTALARVVLRTQLRKLGlLLPEQRLVPSIKTIYQDMWANNGDIVSRQYAGTAALKGDYTrtgerklTGLMKDGYNS
 |  || || ||||.||||||| |||.|.  || .||  |. |   ...|  .. .....| .||| .|. |||| ||.|.         .. .|||  |
evekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk.lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgars

ASRYVQNQLKDAFRQVAIDLMLGNQEIQEDL
 .| .|| . |. .| ||||.|  .  .|.|
vartiqnnfldsskqeaidllllgntyveel
subfamily_FIG4_pd Subfamily FIG4 174-562 6e-58 187.6 In-house 142-547 (569) alignment 
Range on Protein: 174-562
Range on HMM: 142-547/569.0
FYYSPTGDLTNSIQRHHT--------------------HKGAGYDERFFWNQHMLQDILDTQNKelaRPWIIPIVQGCVQIRECRMTfapeegaqsGGsg
||.| . |||...|   .                     |   ..|.| ||...|. . || ..     |.. |. | |.  .  .          |   
fyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvkt...fdWlleiihGfvsqskisvl.........gk..

adsddsdiKFNLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQILQTA-------EHSVSFVQVRGSVPVFWSQP--GIKYKPPPRIDRDDDESQEA
        . ...||.|||.  ||.|. .||....| .||.||||||...|       ..  ||||.|||||..|||    .. ||| .||. |   . |
........siyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaa

fKTHFEEDLQRYRH-VAIISLI---EQAGREAIVGSAFMKHV-----LLYDSPKLTYITFDFHEYCRGLRFDKVSVLLESIRDVIKEMRYCWADA-EGVI
  .||.. .|||   . |. |.   |.  ||.|. ..| . .     .| .. ||.||..|.. . .    . ..|| .  ....|.  .    .     
.alhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlest

LEQRGVFRVNCMDCLDRTNVVQTALARVVLRTQLRKLGLLL-PEQRLVPSIKTIYQDMWANNGDIVSRQYAGTAALKGDYTRTGERKLTGLMKDGYNSAS
  |.|. |.||.|||||||. | ....| |. || .||..  ..  .   . .. .... . || .. ||.|.   .   | .  ....   .|  .. .
kiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlk

RYVQNQLKDAFRQVAIDLMLGNQEIQEDL
||  | ..|| .| ||.|.||  . .| |
ryysnsfvdadkqdainlflGvyspregl
hSac2 Inositol phosphatase 584-688 1.7e-22 68.2 Pfam-A 10-112 (115) alignment 
Range on Protein: 584-688
Range on HMM: 10-112/115.0
EEDIKQRIQQCSRLLLPKNEAKmnLGGWVLIDCDSGDlddSGEDDRDIILIISEKAYYIASYDDEAEKITQYERIPIDAMTAVGIG--SATTFF-SHAKQ
|| ..| |..|..|.||..|    .|||.|...|  .   . ... . .|....||.|...||.| ||.||.|||.... . . ||  | .| . .  ..
eelreqaiekckklvlpddeel..iggWlLvsidhsn...ktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtysestlsedksen

RCVRIYHS
 ..|| ..
lglrinyr
Sac_COG5329 47-215 1.2e-13 41.1 In-house 60-188 (1070) alignment 
Range on Protein: 47-215
Range on HMM: 60-188/1070.0
KVFGVIGKLriHPESEWRLLLIRSHRLVGQLPKGHDVYCITRIAVLPLSQNGHPDIEIERcdkhhfgirqkanlilgpaegqqkslaktwnsikSVAQVK
...||.| .    | .  | .|.    |.|  .|. .| |  . ...| .|  .|.|||.                                  . |...
eiygvlGli..elegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeies..................................deaste

K---KevkereklerRILEELNRMFTeSDWFYYSPTGDLTNSIQRH----HTHKGAGYDERFFWNQHMLQDILDTQ
|   .            . ||  ...  . ||.| . |.||..|..    .  .   .||.|.||. .|.....  
klrse..........hpcselkkLls.ngsFYfStdfditntLqkrlkeelelsvdtadeefmwnsflleelinyr