Gene LHPP-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP137_AA protein Get Run
SpurP137_AA_11-268 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LHPP_pd Subfamily LHPP 14-245 3.8e-97 315.7 In-house 1-227 (227) alignment 
Range on Protein: 14-245
Range on HMM: 1-227/227.0
VLLDITGVLYNstdeGGVPIPGSIEAVKRLKASGVRVRFCTNETQCTRQQLVDKLQRLGFELSVPEVFAPAPAACQLLKARGLTPHLLVYPGVLPEFEAF
||||..|||.|    ....|||..||.|||...||.|||.||.|......||..|.||||.... |.|....||.|||..| |.|.||| ..| ..||..
vllDlsGvlhn....edaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedi

DlGAKPTCVVVGDAADIFNYETMNNTFRKLLEMDPPVLISMGVGKYY-RHGGeLMLDVGPFTKALEYAVRCEAIVVGKPDRNFFLGALQDMGVQPQNAIM
|  .||..||.|.|.. |.|||.|..||.|||.. ..||... |||| |. | |.|..|.|.||||||....| |||||...||  ||...||.|..|.|
d.tdkpnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavm

VGDDIVNDVGGAQKCGLKGLQVRTGKFRPSDEH
.|||. .||.||.|.||.|..|.||||||.||.
iGDdvedDveGAlkaGlrgvlVktGkfrpedek
Chronophin_1 12-262 5.1e-31 99.1 In-house 2-256 (261) alignment 
Range on Protein: 12-262
Range on HMM: 2-256/261.0
EGVLLDITGVLYNstdeGGVPIPGSIEAVKRLKASGVRVRFCTNETQCTRQQLVDKLQRLGFE-LSVPEVFAPAPAACQLLKARGLTPHLLV--YPGVLP
. ||||. |||..    |.  .||  |....||  | .| | ||... ||..|...|.|||.. ... |.|. | || .||..  .. . .|    |.  
qlvLlDldGVlik....geeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrk

EFEAFDL--G----AKPTCVVVGDAaDIFNYETMNNTFRKLLEMdpPVLISMGVGKY-YRHGGeLMLDVGPFTKALEYAVRCEAIVVGKPDRNFFLGALQ
|...  |       .... ||||   . ...| ...  . . .     ..     ..  .. |  .   |  . |.| |   |..|||||..  |  ||.
elreaGlrlvdepedrveaVvvGyd.eelsfeklaeaialirdg..alfvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvvGKPepvmfeeale

DMGVQPQNAIMVGDDIVNDVGGAQKCGLKGLQVRTGKFRPSDEHHP--EVRPDGFVENLAHAV
..|..|....|||| .  |.  ....||. | |.||  .... ..   ..|||  ||..|  .
kigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqaykkdlrPdavvesiadll
Hydrolase_6 Haloacid dehalogenase-like hydrolase 14-94 3.8e-19 60.0 Pfam-A 1-77 (101) alignment 
Range on Protein: 14-94
Range on HMM: 1-77/101.0
VLLDITGVLYNstdeGGVPIPGSIEAVKRLKASGVRVRFCTNETQCTRQQLVDKLQRLGFELSVPEVFAPAPAACQLLKAR
.|.|. |||..    |  .|||. ||.|.|.|.|..| ..||... .......||..||....  .|. .| || ..|| |
flfDvdGvLwr....gdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkr
subfamily_PGP_pd Subfamily PGP 111-263 2.6e-18 57.3 In-house 122-277 (279) alignment 
Range on Protein: 111-263
Range on HMM: 122-277/279.0
EAFDLGAKPTCVVVGdAADIFNYETMNNTFRKLLEMDpPVLISMGVGKYYRHGGE-LMLDVGPFTKALEYAVRCEAIVVGKPDRNFFLGALQDMGVQPQN
|...|  .  .||||   . ..|  . .. . | | .  ...     . ..   |  . . |.. .|.| |.  ...|.||| .. .   |.   ..|. 
eelkldkdvgAVvvg.vdeklsyakllkAanyLrepe.vlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidper

AIMVGDDIVNDVGGAQKCGLKGLQVRTGKFRPSDEHHPEV----RPDGFVENLAHAVD
..|.|| .  |.  ...|||. | | .|  . .| .. .      || ....||. ..
tlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkeeklvPdyyldsladlle
Hydrolase_like HAD-hyrolase-like 188-260 6.4e-17 52.6 Pfam-A 2-74 (75) alignment 
Range on Protein: 188-260
Range on HMM: 2-74/75.0
VGKPDRNFFLGALQDMGVQPQNAIMVGDDIVNDVGGAQKCGLKGLQVRTGKFRPSDEHHPEVRPDGFVENLAH
 |||.. ..  ||...|. |....|.||..  |. .|...|.. . |.|| .|. |  ... .|| .|..|. 
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlklakakpdyvvddlee
subfamily_PGP_pd Subfamily PGP 14-98 1.2e-15 48.6 In-house 2-83 (279) alignment 
Range on Protein: 14-98
Range on HMM: 2-83/279.0
VLLDITGVLYNSTDeggvPIPGSIEAVKRLKASGVRVRFCTNETQCTRQQLVDKLQRLGFE-LSVPEVFAPAPAACQLLKARGLTP
||.|. ||| ..      .|||..||...||. | .| |.||.   .|..|..|...|||| ..  |.. .| |... || .  . 
vlfDcDGVlWlget....aipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqkkfek
Chronophin_2 13-92 3.1e-11 34.1 In-house 2-78 (282) alignment 
Range on Protein: 13-92
Range on HMM: 2-78/282.0
GVLLDITGVLYNstdeGGVPIPGSIEAVKRLKASGVRVRFCTNETQCTRQQLVDKLQRLGF-ELSVPEVFAPAPAACQLLK
.||.|  ||..|    |   ..|. | |.||.  | .| | ||... .|...| |. |||| ..   ..|. |  . ..|.
nvlfdcdgviwn....gekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylr
Chronophin_2 163-237 3.4e-11 33.9 In-house 169-243 (282) alignment 
Range on Protein: 163-237
Range on HMM: 169-243/282.0
GGELMLDVGPFTKALEYAVRCEAIVVGKPDRNFFLGALQDMGVQPQNAIMVGDDIVNDVGGAQKCGLKGLQVRTG
.|. .   | .| ||| |   .|.|.||| | .|    ... |.| ...|.|| .  |.   ..|||. .   ||
dgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdrletdilfgsncglstvltltg
HAD_2 Haloacid dehalogenase-like hydrolase 179-234 3.8e-09 28.4 Pfam-A 122-176 (176) alignment 
Range on Protein: 179-234
Range on HMM: 122-176/176.0
YAVRCEAIVVGKPDRNFFLGALQDMGVQPQNAIMVGDDIvNDVGGAQKCGLKGLQV
  . .. . . ||| ...  .|.  ||.|.......| . .|| .|...|... .|
avftsddvgapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv
Hydrolase haloacid dehalogenase-like hydrolase 184-228 2.8e-07 22.5 Pfam-A 172-215 (215) alignment 
Range on Protein: 184-228
Range on HMM: 172-215/215.0
EA--IvvGKPDRNFFLGALQDMGVQPQNAIMVGDDIvNDVGGAQKCG
 |  .  |||.   |. |.. ....|....||||.. ||. .....|
faevv..gkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
CECR5_TIGR01456 210-268 3.2e-07 20.0 In-house 304-361 (370) alignment 
Range on Protein: 210-268
Range on HMM: 304-361/370.0
AIMVGDDIVNDVGGAQKCGLKGLQVRTGKFRPSDEHHpEVRPDGFVENLAHAVDLLLQH
  ||||.   |. ||.. ||    |.|| .  .||.. |....  |..  .||. .|..
lymvGDnPasDiiGarnaGlfsilvktgvydgadelk.egkarlvvdsvseavikiLek