Gene LHPP-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP138_AA protein Get Run
SpurP138_AA_7-256 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LHPP_pd Subfamily LHPP 10-233 1.3e-106 346.6 In-house 1-226 (227) alignment 
Range on Protein: 10-233
Range on HMM: 1-226/227.0
VLIDLSGTIHIEDAAIPGAVAALQRLRERTTNIKFVTNTTKESMTTLRNRLSRIGFDIKQNEIFSSLTAARNKVQEMGCRPMLLLQDSAKEDFKDICTDD
||.||||..|.||||||||| ||.|||.......|||||||||...| .||.|.|||....|||.||.|||. ..|. .||.||..|...|||.||.||.
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedidtdk

PNCVVVGLSPDSFNYRTLNQAFRLILD--GHPLIAIHKAKYFKRQDGLALGPGAFVEGLEYATGVRATVVGKPERAFYQEALKTMSCAPEEAVMIGDDVE
||.||.||.|.||.|.||||||||.|.  ...||||.|.||.||.|||||||||||..|||||||.|.|||||...|...||......||||||||||||
pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmiGDdve

GDVQGAQTIGMKGFLVKTGKYRPGDE
 ||.||...|..|.||||||.||.||
dDveGAlkaGlrgvlVktGkfrpede
Chronophin_1 9-233 2.5e-41 132.9 In-house 3-236 (261) alignment 
Range on Protein: 9-233
Range on HMM: 3-236/261.0
AVLIDLSGTIHIEDAAIPGAVAALQRLRERTTNIKFVTNTTKESMTTLRNRLSRIGFD-IKQNEIFSSLTAARNKVQ--EMGCRPMLLLQDSAKEDFKD-
 ||.|| | .  ...|.|||  ....|... ... |||| ...  . | .||.|.|.| ....||||| .||.. ..  ... . ..| ..  ...... 
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrkelrea

--ICTD----DPNCVVVGLSPdSFNYRTLNQAFRLILDGHPLIAIHKAKYFKRQDGLALGPGAFVEGLEYATGVRATVVGKPERAFYQEALKTMSCAPEE
  ...|    ... ||||  . ..... |..| .|| ||  ..|  . ... ...| | | |. .  .| |.| ...||||||.. ..|||....  |||
GlrlvdepedrveaVvvGyde.elsfeklaeaialirdgalfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekigadpee

AVMIGDDVEGDVQGAQTIGMKGFLVKTGKYRPGDE
.||.|| .. |.. ..  |.. .|| ||  .. . 
tvmvGDRldTDilagaraglstllvltGvseleea
Chronophin_2 9-226 1.8e-22 70.9 In-house 2-243 (282) alignment 
Range on Protein: 9-226
Range on HMM: 2-243/282.0
AVLIDLSGTIHIEDAAIPGAVAALQRLRERTTNIKFVTNTTKESMTTLRNRLSRIGF-DIKQNEIFSSLT-A---------ARNKVQEMGCRPMLL-LQD
.||.|  | |   . |..||.. ..|| ..  |. |||| .. .   . ....|.|| |.....||||   .         .| ||  .|.  ..  |..
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadvrgkvfviggeglrkelre

SAKEDFKDI---------CTDDPN--CVVVGLSpDSFNYRTLNQAFRLILDGHPL-IAIHKAKYFKRQDGLA-LGPGAFVEGLEYATGVRATVVGKPERA
.  .  .|          |. ||.   |.||   ... .  | .|   . | . | .|  .  .   .||    | |..   || |.| .|||.||| | 
agvpvvedadeqeasiydcaldpdvravlvgyd.ekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrf

FYQEALKTMSCAPEEAVMIGDDVEGDVQGAQTIGMKGFLVKTG
...   . .|  | ...|||| .| |.   .  |..  |  ||
mfecissqfsvdparslmigdrletdilfgsncglstvltltg
subfamily_PGP_pd Subfamily PGP 105-232 1.1e-18 58.5 In-house 124-253 (279) alignment 
Range on Protein: 105-232
Range on HMM: 124-253/279.0
IC-TDDPNCVVVGLSpDSFNYRTLNQAFRLILDGH-PLIAIHKAKYFKRQDGLA-LGPGAFVEGLEYATGVRATVVGKPERAFYQEALKTMSCAPEEAVM
.    | ..||||.  . ..|  | .| . . . .  ..|  . . .. ....   |.|..|. .| |.| ...|.|||..   .  |.  .  || ..|
lkldkdvgAVvvgvd.eklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlm

IGDDVEGDVQGAQTIGMKGFLVKTGKYRPGD
||| .. |.. ... |..  || .| ..  |
iGDrlktDilfgkncGlqtLlvlsGvtkled
Hydrolase_like HAD-hyrolase-like 177-247 1.4e-18 58.0 Pfam-A 2-72 (75) alignment 
Range on Protein: 177-247
Range on HMM: 2-72/75.0
VGKPERAFYQEALKTMSCAPEEAVMIGDDVEGDVQGAQTIGMKGFLVKTGKYRPGDEGKITQPPAEICEDF
 |||.. .|..||. ... |.|.|||||... |...|. .|..  ||.|| .|..|  .    |. ...|.
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlklakakpdyvvddl
Hydrolase_6 Haloacid dehalogenase-like hydrolase 10-94 5.6e-18 56.2 Pfam-A 1-87 (101) alignment 
Range on Protein: 10-94
Range on HMM: 1-87/101.0
VLIDLSGTIHIEDAAIPGAVAALQRLRERTTNIKFVTNTTKESMTTLRNRLSRIGFDIKQNEIFSSLTAARNKVQE--MGCRPMLLL
.|.|. |... .| |||||. ||..||..  .. ..|| ...|  .. ..|...|.|........| |||.. ...   . . ... 
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrkadkkvlvig
subfamily_PGP_pd Subfamily PGP 10-80 2.4e-12 37.7 In-house 2-73 (279) alignment 
Range on Protein: 10-80
Range on HMM: 2-73/279.0
VLIDLSGTIHIEDAAIPGAVAALQRLRERTTNIKFVTNTTKESMTTLRNRLSRIGFD-IKQNEIFSSLTAAR
||.|  |.. ... |||||. ||..|..   .. ||||   .|   | ... ..||. .|..||.||  |. 
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaia
HAD_2 Haloacid dehalogenase-like hydrolase 175-223 1.1e-09 30.1 Pfam-A 129-176 (176) alignment 
Range on Protein: 175-223
Range on HMM: 129-176/176.0
TVVGKPERAFYQEALKTMSCAPEEAVMIGDDVeGDVQGAQTIGMKGFLV
. . ||. ..|. .|..  ..|||...|.| .  ||..|. .|.....|
vgapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv
CECR5_TIGR01456 198-256 6e-07 19.2 In-house 303-360 (370) alignment 
Range on Protein: 198-256
Range on HMM: 303-360/370.0
EAVMIGDDVEGDVQGAQTIGMKGFLVKTGKYRPGDEGKITQpPAEICEDFPAAVELLLK
.  |.||.   |. ||.  |.   ||||| |  .|| | .. .  . ..   ||. .|.
klymvGDnPasDiiGarnaGlfsilvktgvydgadelkegk.arlvvdsvseavikiLe
Hydrolase haloacid dehalogenase-like hydrolase 170-215 1.2e-06 20.4 Pfam-A 167-213 (215) alignment 
Range on Protein: 170-215
Range on HMM: 167-213/215.0
TG--VRATVVGKPERAFYQEALKTMSCAPEEAVMIGDDVeGDVQGAQT
..  | | ||||||   .. |.. .   |.|..|.||.|  |..... 
edslvfaevvgkPepklfvaaieeLqidpgevamvGDgv.nDapalaa