Gene PXYLP1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily PXYLP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP178_AA protein Get Run
SpurP178_AA_154-578 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PXYLP1_pd Subfamily PXYLP1 156-578 4.9e-202 662.7 In-house 1-419 (419) alignment 
Range on Protein: 156-578
Range on HMM: 1-419/419.0
TGYCNPPDREITGEEGKFKPGFNLKAAYVVARHGDRTPMqefADIPNSNwHPQWNCDLKQASKTITsDTLKRFVDQMQAEIIKGDMTGALGTFKNLPV--
..|||.||.||..||||.|.||.|||..||.|||||||.   .|||.|. ....||||..|||... |.||.|.|....|....|.....|..|.||.  
llycnipdveirseeGkikegfkLkavlvvirhGDrtPl...sdipksk.raeinCdlsaasknlv.dklksfldnssseasgsdfenkvgplkslPllp

NHNGICKKSQLTPIGWLQHLELGTFFRKAYGRT---LVQNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLNdTIRIKTVPNVNFCpLDMCACPAL
||..||...|||..|..||||.|...||.|...   |....||..|......|...||.|||.|..||...||.|. .||....|.|.|| |..|.||||
nheriCelgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpkaklk.airvrespsvafC.lgeCsCPal

DHLIKDKEAQHAKLMRGnpKFMNVMRSVAQTLYGTTLITTLPGINQVAEILTTLVCHNMPYPYGSSGTITPIQHAVYHKLLEEtwVSQSHVKDGTYEKVG
......|||....|.||  |...||.||..||.||.|.|||.||......|.|..|||...|....|...|....|.|||..|  .||...|...|...|
lrkrlekeadkqlLlrg..kvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvlhklade..lsqrsakksyyklsG

RMFIQPLLTDMLRTMYKITQGVSKPRFVFNSGHDITIRPIVDGLKLSSPGWPHYASRVVFELWGRATSKEHFLRVLAYGKDQTDKVQFCKG--KMTADGL
.....|||.|....|.||..||.|..||..||||.|.||.|..|.||......||||.||||..|..|||..||||..|||.|.||.||.|  |.....|
llraypllrdivsrmlkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDvtqkvdfCegdskrskkdl

CPFSALVSFVEKENMEYFYSESYRDACTRT
||...||.||.|..........|.|||||.
CPlenlvrfvkkdyfsalsatnykdaCtrv
0049059 Phosphoglycerate mutase-like 155-575 4.5e-58 190.2 In-house 21-434 (435) alignment 
Range on Protein: 155-575
Range on HMM: 21-434/435.0
KTGYCNPPDreITGEEGKFKPGFNLKAAYVVARHGDRTPMQEFADipnsNWHPQWNCDLKqASKTITsdtlkrfvdqmqaeiikgdmtgalGTFKNLpVN
.. |.. |.  ..| . .  .|..|| . |..|||.|||.. . .    .. . |...|. .. . .                        | .. |  .
lspyfsapg..vfgisldvpegcelkqvqvlfRHGaRtPtsklik....klealweklls.lltypn........................gplsfl.nd

HNGICKKSQLTPIGWLQHLELGTFFRKAYgRTLvQNQEllrdVSNFQSTMNLRTQQSAFAFMYGFFEKA----------TLNDTIRIKTVPNVNFCPlDM
.|.... ..||| |. |. ||| ..|| |   |  |..       ..|.   ||.||| ||..|.|.            . .. . | ||.  |..  ..
wnyplgageLTplGreqayelGkrlrkrY.gfL.ynpd....evyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl.py

CACPALDHLIKdKEAQHAKLMRG-NPKFMNVMRSVAQTLYGTtlITTLPGINQV--AEILTTLVCHNMPYPYGSsgTITPIQHAVYHKLLEETWVSQSHV
..|||.|.|.| . .. .. .   .... ........ |  |  ..... .. .   ..|.. ..|..| |. |   .|. .  |.  |    .  . . 
dscpafdellk.ellasdeflelflerilkllqellpglglt..psdvldlydlckydtlllgyahglplpfcs..lfteeelevleyladlefyylygy

KDgtyeKVGRMFIQPLLTDMLRTMYKITQGVS----------------KPRFVFNSGHDITIRPIVDGLKLSSPGW----------------------Ph
 |    .....   ||| ..|. . .. .| |                ...... ..|| || |.   | | .. .                      | 
gd....eiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivP.

YASRVVFELWGRATSKEHFLRVLAYGKDQTdkVQFCKGKmtADGLCPFSALVSFVEKenmeyFYSESYRDAC
|||..||||.   ...|.. |||  ||...  ...|...   .||||.......|.|     | .... | |
yasnlvfElyecpdgneyyVrvlyngkvlp..lpgcgsg..pgglCplddFkelvkk.....flpgddfdeC
0048439 Phosphoglycerate mutase-like 175-560 1.2e-57 189.0 In-house 5-388 (391) alignment 
Range on Protein: 175-560
Range on HMM: 5-388/391.0
PGFNLKAAYVVARHGDRTPMQEFADIpnsnWHPQWNCdlkqasktitsdtlkrfvdqmqaeiikgdmtgalgtfknlpVNHNGICKKSQLTPIGWLQHLE
.| .|| ..|..|||.|||.. . ..    ..| .|.                                         .  || |. ..||| |. |. |
agcelkqvqvlfRHGaRtPtssypnk....ldpllnk.........................................llpngpcglgeLTplGreqlye

LGTFFRKAYgrtlVQnQELL-------RDVSNFQSTMNLRTQQSAFAFMYGFFEKATLNDTIRIKTVP-NVNFCPLDMCACPALDHLIKDKEAQHAKLMR
|| ..|| |    |. . ||       ..   ..|.   ||.||| ||..|.|.  .|.  ..| ... .  . ||... ||.|..|  ..  ..   . 
lGrrlrkrY....vd.lgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnplpintcplledlllldalsalprfy

GNPKFmNVMRSVAQTLYGTTLI-------------------------TTLPGINQVAEILTTLVCHNMPYPYG-SSGTITPIQHAVYHKLLEETWVSQSH
 .... . .. | . ..| .|.                         ..|  .. . ..|..  .|..|.|.   .....| . ... .| .| .  . .
lseil.erlaevlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltg

VKdgtyeKVGRMFIQPLLTDMLRTMykITQGVSKPRFVFNSGHDITIRPIVDGLKLSSP------GWPHYASRVVFELWGRATSKEHFLRVLAYGKDQ--
 .     ..... ..||| ..|. .  ...| |.|.... ..|| || ..   | | ..      ..|.|||..||||.   ...|.. |||  |..   
sg.....eiaklaggpllneilddl..vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldl

----------------TDKVQFCKGKmtADGLCPFSALVSFVEK
                . ....|...   .||||....|..|.|
prdltlldldefllrlvlplpgcgsg..pgglCplddFvelvkk
0048946 Phosphoglycerate mutase-like 173-578 9.3e-57 185.9 In-house 35-412 (447) alignment 
Range on Protein: 173-578
Range on HMM: 35-412/447.0
FKPGFNLKAAYVVARHGDRTPMQEFADipnsNWHPQWNCDLKQaSKTITSDTLKrFVDQMQAEIIKGDMTGalgtfknlpvnhngiCKKSQLTPIGWLQH
  .|..|| ..|. |||.|||.. . .    ...| ...  .. . .. .. |. |...... . .. . .               |. .|||| |. |.
vpegcelkqvqvlfRHGaRtPtkkylk....gleplldllkna.nvlelggdls.flndwkyqlkneplwp...............cglgqLTplGreql

LELGTFFRKAYgRTLVQnqelLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLND--TIRIKTVPNVNFCPLDMcACPALDHLIKDKEAQHAKLmrgnpk
 ||| ..|| |  .| .     ..   ..|.   ||.||| ||..|.|.. . ..  .| | |||. |...|..  |||...|.|.  |.  |       
yelGkrlrkrY.lgllp....npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp.sCpafkellkkelaeelke......

FMNVMRSVAQTLYGtTLITTLPGINQVAEILTT-LVCHNMPYPYgssGTITPIQHAVYHKLLEETWVsqshVKDGTYEKVGRMFIQPLLTDMLRTMYKIT
...  ..  ..|.| .|  ||  .. . ..|   ...|... .    . .|| .  |.. |    .      . | .....|.   ||| ..|. . ...
llkellerlkkllg.glnltlsdvydlydlllyetaihglsplc...slftpeelevleyladlefy....yeygygdelarlaggpllneilarledai

QGVSkpRFVFNSGHDITIRPIVDGLKLSSPGWPH------------------YASRVVFELWGRAT----SKEHFLRVLAYGKDQTdkVQFCKGKmtADG
.| |  .... ..|| || ..   | |... .|.                  |||..||||.   .    ..|.. |||  |....  ...|...   .|
sgds..klylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplp..lpgCgsg..pgg

LCPFSALVSFVEKEnMEyfyseSYRDACTRT
|||.........|  ..     .. ..|  |
lCplddFkellkkf.lp.....dweklCglt
0047369 Phosphoglycerate mutase-like 155-575 5.6e-56 183.5 In-house 22-436 (438) alignment 
Range on Protein: 155-575
Range on HMM: 22-436/438.0
KTGYCNPPDREITGEEgkFKPGFNLKAAYVVARHGDRTPMQEFADipnsNWHPQWNCDLKQasKTITSdtlkrfvdqmqaeiikgdmtgalGTFKNLpVN
.. |.. |.  . ...  . .|..|| ..|..|||.|||.    .    ...| |.....   .|..|                       | .. |  .
lspyfsapgvglisld..vpegcelkqvqvlfRHGaRtPtksklk....kleplwellena..ttyps.......................gplsfl.nd

HNGICKKSQLTPIGWLQHLELGTFFRKAYgRTLvqnqeLLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLND-------TIRIKTVP---NVNFCPLDM
..|.|.  |||| |. |. ||| ..|| |   |       .||  ..|.   ||.||| ||..|.|.  . .        .| | |.|   ......|..
wlgpcgagqLTplGreqayelGkrlrkrY.glL.....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllps

CACPALDHLIKDKEAQHAKLMRGNPKFMNVMRSVAQTlYGTTlITTLPGINQVAEILTTLVCHNMPYPYGSSGTITPIQHAVYHKLLEETWVSQSHVKDg
. |||.|.|.|.  |    | . .............. .. | ..... ...   . |   .... ...   . .|| .  |.. |  . .       . 
dscpafdellkeflasdeflelllkdilkrlkkllpg.lnlt.psdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygn.

tyeKVGRMFIQPLLTDMLRTMYKITQGVS----------------KPRFVFNSGHDITIRPIVDGLKLSSPGW----------------------PhYAS
   ..... ..||| ..|. . .. .| |                ...... ..|| || ..   |.|... |                      | |||
...elaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivP.yas

RVVFELWGRATSKEHFLRVLAYGKDQTdkVQFCKGkmTADGLCPFSALVSFVEKenmeyFYSESYRDAC
..||||.   ...|.. |||  ||...  ...|..    .||||.......|.|     .  ......|
nlvfElyecpsdgeyyVrvlyngkvlp..lpgcgs..gpgglCplddFkelvkk.....llpgdfeelC
0049226 Phosphoglycerate mutase-like 179-575 4.1e-55 180.3 In-house 3-340 (342) alignment 
Range on Protein: 179-575
Range on HMM: 3-340/342.0
LKAAYVVARHGDRTPMQEFADIPNSNWHpqwncdlkqasktitsdtlkrfvdqmqaeiikgdmtgalgtfknlpvnhnGICKKSQLTPIGWLQHLELGTF
|| ..|..|||||||.. .   . ..|.                                                  . |. ..||| |. |. ||| .
LkqvqvliRHGdRtPlakgpldflnewf..................................................wgcglgeLTplGreqayelGrr

FRKAYGRTLvqNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLNDT--------IRIKTVPN---VNFCPlDMCACPALDHLIKDkEAQHAKLMRG
.|| |.  |  .. . .|.  ..|.   ||.||| ||..|.|.  . . .        | | |.|.    .... ... ||..|.|.|.  .. . ... 
lrkrYlgll..pstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllll.pydscpnfdkllke.llkseevqlf

NPKFMNVMRSVAQtLYGTTLITTLPGINQVAEILTTLVCHNMPYPYGSSGtITPIQHAVYHKLLEETWVSQshvkdGTYEKVGRMFIQPLLTDMLRTMYK
............. |.|..|.|  . .. . ..|.  ..|..|.|   |   |. .. ..  |    .  .     |  |...|. . ||| ..|. . .
leeildllkklsk.llglnlstlsdvadtlydlllyelahglplppwcsl.ftleelkalyaldllyyygi.....gygeeiarlaggpllneilarlee

ITQGVSKPRFVFNSGHDITIRPIVDGLKLSSPGWPHYASRVVFELWGRAtsKEHFLRVLAYGKD----QTDKVQFCkgkmtaDGLCPFSALVSFVEKenm
...| |...... ..|| || ..   |.| ....|.|||..||||.     .|...||| .|.     .| .. .|      |||||.......|.|   
aiegpsdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd..geyyVrvlynggvlslpvtlplpgc......dglcpldefkelvkk...

eyFYSESYRDAC
  |. ... ..|
..flpgdfeelC
0046349 Phosphoglycerate mutase-like 175-564 9.4e-55 179.4 In-house 3-380 (409) alignment 
Range on Protein: 175-564
Range on HMM: 3-380/409.0
PGFNLKAAYVVARHGDRTPMQEFADIPnsNWHPQWNCdlkqasktitsdtlkrfvdqmqaeiikgdmtgalgtfknlpvnhNGICKKSQLTPIGWLQHLE
|| .|| ..|..|||.|||.. .  .|  ||......                                            || |. .|||| |. |. |
PgceLkqvqvlfRHGaRtPtkklsflp..nwpginwt............................................ngpcgagqLTplGreqaye

LGTFFRKAY--GRtLVQNQE-LLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLND--------------TIRIKTVP-----NVNFCPLDMCA-CPALD
|| ..|| |  .  |....    .|.  ..|.   ||.||| ||..|.|.  . .               .| |.|||      .... | .   |||||
lGkrlrkrYvdlg.LlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpald

HLIKDKEAQHAKLMR-----------GNPKFMNVMRSVAQTL----YGTTLITTLPGINQVAEILTTLVCHNMPYPyGSSGTITPIQHAVYHKLLEETWV
.|.|.  ..... ..            ...........|. |    .|..|.. |  .. . ..|.   .|..|.|    . .|| .  |. .|    . 
kllkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplp.pwcdlftpeelkvlayladleyy

SQSHVkdgtYeKVGRMFIQPLLTDMLRTMYKITQGVS------KPRFVFNSGHDITIRPIVDGLKLSS-----PGWPHYASRVVFELWGRATSKEHFLRV
 . .       .....  .||| ..|. . ....| .      ...... ..|| || ..   | |.      ...|.|||..||||.   ...|.. ||
ylygs....g.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrv

LAYGKdqtdKVQFCKGKMTadglCPFSALVSFVEKENME
|  |.     ....... .    ||.| ......|   .
lyngg....plplpgcgeg....cplsefkellkkrlpg
0053031 Phosphoglycerate mutase-like 179-575 2.2e-54 178.1 In-house 3-340 (342) alignment 
Range on Protein: 179-575
Range on HMM: 3-340/342.0
LKAAYVVARHGDRTPmqefADIPNSNWHPQWNCdlkqasktitsdtlkrfvdqmqaeiikgdmtgalgtfknlpvnhngICKKSQLTPIGWLQHLELGTF
|| ..|..|||.|||     .  . .....|..                                               |. ..||| |..|..||| .
LkqvivlvRHGaRtP....lskgpldplnewfy..............................................pcgageLTplGreqayelGrr

FRKAYGRTLvqNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLNDT--------IRIKTVPNVNF---CPlDMCACPALDHLIKDKEaQHAKLMRG
.|| |.  |  .. . .|.  ..|.   ||.||| ||..|.|.. . . .        | | |.| ..    .| ... |||.|.|.|.   . . ... 
lrkrYlgll..pstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllp.nydpcpafdkllkeal.aseevkel

NPKFMNVMRSVAQTLyGTTLITTLPGINQVAEILTTLVCHNMPYPygssGTITPIQHAVYHKLLEETWVSQShvKDGTYEKVGRMFIQPLLTDMLRTMYK
.... .........| |.|| . |  .. . ..|   ..|..|.|      .|  .  ... | .. .  .   . |  ...... . ||| ..|. . .
lerylellqklskgl.gltlsdlldlvsdlydlllyelahglplp....pwctlftleelkalyaldllyyy..glgpgnelaklaggpllneilarlee

ITQGVSKPRFVFNSGHDITIRPIVDGLKLSSPGWPHYASRVVFELWGRAtsKEHFLRVLAYGK------DQTdkVQFCkgkmtaDGLCPFSALVSFVEKe
...| ....... ..|| || ..   | |  ...|.|||..||||.     .|...|||  |.      ...  . .|      |||||.|.....|.| 
kisgpldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp..geyyVrvlynggtlseplvlp..lpgc......dglcplsefkelvkk.

nmeyFYSESYRDAC
    .. ......|
....llpgdfeklC
subfamily_ACP2_pd Subfamily ACP2 177-564 3.1e-41 134.1 In-house 7-350 (361) alignment 
Range on Protein: 177-564
Range on HMM: 7-350/361.0
FNLKAAYVVARHGDRTPMQEFADIPnsnwhpqwncdlkqasktitsdtlkrfvdqmqaeiikgdmtgalgtfknlpVNHNGI-CKKSQLTPIGWLQHLEL
 .||   |. |||||.| ... . .                                                   .. . .    .|||. |  |..||
rkLkfvqvlfRHGdRsPlntypndk...................................................ykedewpqglGqLTeeGmqqqyeL

GTFFRKAYGR-TLVQNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEK---ATLNDTIRIKTVP-----NVN-FCPLDMCACPALDHLIKDKEAQhAKLM
|.|.|| |.. |   ...  ..  ...|.   || .|| ....|.|..    . .|... ..||     . .  .  ... ||. |.|... ... ... 
GkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakes.pevk

RGNPKFMNVMRSVAQtLYGTTLITTlpginQVAEILTTLVCHNMPYPYgssGTITPIQH-AVYHKLlEETWVSQSHVKD----GTYEKVGRMFIQPLLTD
. . .  .... . .  .|...        .....  ||.|... ..     ....  .  .. || ||.  ... ..      . ... .. . ||| .
klleenkelleklse.stgedidle.....nfyqlsdtlicerkyane...lnlpewandelfekl.eeladkvkeaefglnnektrelkklrgGpllne

MLRTMYKITQ---GVSKPRFVFNSGHDITIRPIVDGLKLSSPGWPHYASRVVFELWGRaTSKEHFLRVLAYGKDQTDKV----QFCKGkMTAdglCPFSA
.|  | ....     .| .... |.|| |. .. . |.. . ..|.|||....||. . ........||   ....|.     ..|||  .    || |.
llenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyee.ddgkplvkvlyrnetskdppeltlpgCkg.eed...Cplsk

LVSFVEKENME
. ..|..  ..
fkkivkpfipd
His_Phos_2 Histidine phosphatase superfamily (branch 2) 179-526 3e-33 108.1 Pfam-A 2-345 (347) alignment 
Range on Protein: 179-526
Range on HMM: 2-345/347.0
LKAAYVVARHGDRTPMQEFADIPNSNWHPQWNCdlkqasktitsdtlkrfvdqmqaeiikgdMTGALGTFKNLPVNH-----NGICKKSQLTPIGWLQHL
||   || |||||||.|.|.    | .  .                                ....| . .. | .      . |.|  .||. |  |. 
LkgvvvviRHGdRtPkqkfkksvtsekfisllk.............................lknvlekkghfpgtkrkeklqlilkwgglThsGrkqae

ELGTFFRKAYGrtLVQNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKAT-----------LNDTIRIKTVPN-----VNFCPLDMCACPALDH-LIKD
||| ..|. |.  .  . .| ..   . |.   |...|| ||..|....                .. . |...      .... . ..|||..  .|| 
elGeqlrqrYp..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikv

KEAQHAKLMRGNPKFMNVMR-SVAQTLYGTTLITTLPGINQVAEILTTLV-CHNMPYPYGSSGTITPIQHAVYHKLLEETWVSqshvkDGTYEKVGRMFI
.. . ...   .... . .. .. ... | . ..     . . . ... .  .... |   ..  .  .|  . . ||| .        |  .....   
ekrvvelvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelykl.....ygigdeeklkig

QPLLTDMLRTMYKITQGVS---KPRFVFNSGHDITIRPIVDGLKLSS------PGWPHYASRVVFELWGRatSKE-HFLRVL
..||...|. . . ...     . .... ..|| .| ..   | |..       ... |||..||||.    |.. .. |.|
llllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyed..sekkfyvrll
His_Phos_2 Histidine phosphatase superfamily (branch 2) 179-526 3e-33 108.1 In-house 2-345 (347) alignment 
Range on Protein: 179-526
Range on HMM: 2-345/347.0
LKAAYVVARHGDRTPMQEFADIPNSNWHPQWNCdlkqasktitsdtlkrfvdqmqaeiikgdMTGALGTFKNLPVNH-----NGICKKSQLTPIGWLQHL
||   || |||||||.|.|.    | .  .                                ....| . .. | .      . |.|  .||. |  |. 
LkgvvvviRHGdRtPkqkfkksvtsekfisllk.............................lknvlekkghfpgtkrkeklqlilkwgglThsGrkqae

ELGTFFRKAYGrtLVQNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKAT-----------LNDTIRIKTVPN-----VNFCPLDMCACPALDH-LIKD
||| ..|. |.  .  . .| ..   . |.   |...|| ||..|....                .. . |...      .... . ..|||..  .|| 
elGeqlrqrYp..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikv

KEAQHAKLMRGNPKFMNVMR-SVAQTLYGTTLITTLPGINQVAEILTTLV-CHNMPYPYGSSGTITPIQHAVYHKLLEETWVSqshvkDGTYEKVGRMFI
.. . ...   .... . .. .. ... | . ..     . . . ... .  .... |   ..  .  .|  . . ||| .        |  .....   
ekrvvelvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelykl.....ygigdeeklkig

QPLLTDMLRTMYKITQGVS---KPRFVFNSGHDITIRPIVDGLKLSS------PGWPHYASRVVFELWGRatSKE-HFLRVL
..||...|. . . ...     . .... ..|| .| ..   | |..       ... |||..||||.    |.. .. |.|
llllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyed..sekkfyvrll
subfamily_ACP6_pd Subfamily ACP6 177-576 4.2e-22 70.3 In-house 2-372 (376) alignment 
Range on Protein: 177-576
Range on HMM: 2-372/376.0
FNLKAAYVVARHGDRTPMQEfadIPnSNWHPQWNCDLKQASKTITSDTLkrfVDQmqaeIIKGDMTGALGTFKNLPVNHNGICKKSQLTPIGWLQHLELG
..|| . || ||| |||...   .|  . . .|. || .    .. |     | .    .  ..        |  .   .| . | ||| .|  |  .||
leLkqvqvvfrhGartPiks...lP.qeeeveWdkdlleslpdleidyr...vtn....lnGepkPeskieekykkeilkGGafkGqLtkvGmqqvfdLG

TFFRKAYGRTLV-QNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLNDTIRIK--TVPNVNFCP-LDMCACPALDHLIKDKEAQHaKLMRGNPKFM
   || |   .    ||   .     ||   || .||   . | ..|   .    |.  |  . .     ..  || | . ..  ...   .. |  ...
rkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiilytdeedeevlyPnrqrcpllsrayrsvrksa.islpGisedt

NVMRSVAQTLYGttliTTLPGInQVAEILTTLVCHNMPYPYGSSGTITPI-QHAVYHKLleetWVSQShvKDGTYEKVGRMFIQPLLTDMLRTMYKITQG
. ...| .          |  .  . . ..    ||.. |      |  | .||| . .     . .   .| . ... .. . ..| ..|  . | ...
kqiadvldisee....kkldfv.slrDniaArlaHnlkvppilkdvidliekhAveelv....vlleg..gdrpekeilklsvGkvlkeilenlekakek

VSK-PRFVFNSGHDITIRPIVDGLKLSSPGWPHYASRVVFELWGRaTSKEHFLRVLAYGKDQTdkvqfCKGkmTADGLCPFSALVSFVEKenmeYFYSES
 .. ...  .| ||.|. ...  |      || .|. |..||.    ..|.| |||  .| .       .|  . ..|.|.      ...    . ... 
eiparklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyed.kageyfvrvlYqekelr.....lrg..seedlvPlekFkallav....lvlpkd

YRDACT
|...|.
yaaeCk
subfamily_HP2-Group1_pd Subfamily HP2-Group1 390-557 2.2e-15 47.9 In-house 244-406 (422) alignment 
Range on Protein: 390-557
Range on HMM: 244-406/422.0
TLPGINQVAEILTTLVCHNMPYPYGssgtITpiQHAVYHKLLEETWVSQSHVKDGTYEKVGRMFIQPLLTDMLRTMYKITQGVSKPRFVFNSGHDITIRP
 . ..... . | |  |||. .| .    .|  .  . . | |  . |.| .|  . ||  |. |  || |. . . .  .| .  .|.. |||| |. .
didnledlvdclithqchnaaipdk....lt..edlakrgldellyrsysslkypsvekyarvGiGfllkdiwkevnesltGedlrkfllysGhdttliq

IVDGLKLSSPGWPHYASRVVFELWGRATSKE-----HFLRVLAYGKdqTDKVQFCKGKMtaDGLCPFSALVSF
..  |...   || ||| ...||.  .|. .     . .|||  ||    |. ||...     .  |.| .| 
llsalnvdefkwppyasllllellevstapaastpqyavrvlynGk..lkklpfcdane..csyeqfeaylst
subfamily_HP2-Group1_pd Subfamily HP2-Group1 176-326 1.9e-10 31.6 In-house 18-157 (422) alignment 
Range on Protein: 176-326
Range on HMM: 18-157/422.0
GFNLKAAYVVARHGDRTPMQeFADIPNSNWHPQWNCDLKQASKTITSDTLKRFV-DQMQAEIikgdmtgalgtFKNLPVNHNGICKKSQLTPIGWLQHLE
...|| ..|| |||||     .        .  |.||| .||  ..    .| | |..   |           . |   ...| |  .||| .|. |.. 
dvklkqvivvirhGdrvraa.ynGscwdGddaiwdcdlvsaslpvikvekerivvdriyrki...........ylntreedaGdcavaqltleGykqqel

LGTFFRKAYGRTLVQNQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATLN
 |  .||.|  |   . .|      ..|  . || .|| |.. |.. ..|  
nGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtka
subfamily_MINPP1_pd Subfamily MINPP1 174-384 3.8e-08 24.6 In-house 26-217 (420) alignment 
Range on Protein: 174-384
Range on HMM: 26-217/420.0
KPGFNLKAAYVVARHGDRTPMQEFADIPNSNWHPQWNC-DLKQASKTITSDTLKrfvdqmqaeiikgdmtgalgtfKNLPVNHNgicKKSQLTPIGWLQH
. | .|.  ...|||| | | .. .   .....   |     . ...|....|.                      .||.....    ...|.  |  ..
eegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedle......................snleyete...lekslvaqgqeel

LELGTFFRKAYGRTLVqnQELLRDVSNFQSTMNLRTQQSAFAFMYGFFEKATL-NDTIRIKTVP--NV-NFCPLDM-CACPALDHLIKDKEAQHAKL--M
 ||.  . . .   .    .  .|  .|.|| . || .|| ||..| .|.... .|.  | ..   .  .   | .   |.. ..  |..|... .   .
eelakrlarrfpalfe..evynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqesdklLrffdsCkkyknkvkknelnlkeeeef

RGNPKFMNVMRSVAQTLYG
  .... ......|..| .
leskelqkaleeiakrlne