Difference between revisions of "Phosphatase Subfamily PTPRB"
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===== PTPRB (VE-PTP) ===== | ===== PTPRB (VE-PTP) ===== | ||
| − | PTPRB | + | PTPRB, a.k.a. vascular endothelial protein tyrosine phosphatase (VE-PTP), is expressed specifically in endothelial cells and regulates the spreading and migration of endothelial cells during angiogenesis <cite>Mori10</cite>. |
| − | PTPRB binds to VE-cadherin through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation <cite>Nawroth02</cite>. | + | PTPRB binds to vascular E-cadherin (VE-cadherin) through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation <cite>Nawroth02</cite>. |
| − | PTPRB | + | PTPRB associates with endothelial cell (EC)-selective receptor tyrosine kinase Tie2, which maintains vascular integrity <cite>Fachinger99, Winderlich09, Yacyshyn09, Shen14</cite>. |
| − | PTPRB | + | PTPRB regulates vascular endothelial growth factor receptor 2 activity thereby modulating the VEGF-response during angiogenesis <cite>Mellberg09</cite>. |
| + | |||
| + | PTPRB is intrinsically active and its inactivation is dependent on its ligand pleiotrophin (PTN) which is a platelet-derived growth factor-inducible, 18-kDa heparin-binding cytokine that signals diverse phenotypes in normal and deregulated cellular growth and differentiation <cite>Meng00</cite>. PTPRB is glycosylated protein (phosphacan). | ||
| + | |||
| + | PTPRB mutations is observed in cancers. Its mutations are recurrent in [http://en.wikipedia.org/wiki/Angiosarcoma angiosarcoma] <cite>Behjati14</cite>. PTPRB mediates glial tumor cell adhesion by binding to [http://en.wikipedia.org/wiki/Tenascin_C#Role_in_cancer tenascin C] <cite>Adamsky01</cite>. | ||
| + | |||
| + | PTPRB interacts with neuronal receptors and promotes neurite outgrowth <cite>Garwood03</cite>. | ||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
#Adamsky01 pmid=11313993 | #Adamsky01 pmid=11313993 | ||
| + | #Behjati14 pmid=24633157 | ||
| + | #Fachinger99 pmid=10557082 | ||
#Garwood03 pmid=12700241 | #Garwood03 pmid=12700241 | ||
| + | #Mellberg09 pmid=19136612 | ||
| + | #Meng00 pmid=10706604 | ||
| + | #Mori10 pmid=20301196 | ||
#Nawroth02 pmid=12234928 | #Nawroth02 pmid=12234928 | ||
| + | #Shen14 pmid=25180601 | ||
| + | #Winderlich09 pmid=19451274 | ||
| + | #Yacyshyn09 pmid=19116766 | ||
</biblio> | </biblio> | ||
Revision as of 04:19, 25 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
Functions
(summary)
PTPRB (VE-PTP)
PTPRB, a.k.a. vascular endothelial protein tyrosine phosphatase (VE-PTP), is expressed specifically in endothelial cells and regulates the spreading and migration of endothelial cells during angiogenesis [1].
PTPRB binds to vascular E-cadherin (VE-cadherin) through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation [2].
PTPRB associates with endothelial cell (EC)-selective receptor tyrosine kinase Tie2, which maintains vascular integrity [3, 4, 5, 6].
PTPRB regulates vascular endothelial growth factor receptor 2 activity thereby modulating the VEGF-response during angiogenesis [7].
PTPRB is intrinsically active and its inactivation is dependent on its ligand pleiotrophin (PTN) which is a platelet-derived growth factor-inducible, 18-kDa heparin-binding cytokine that signals diverse phenotypes in normal and deregulated cellular growth and differentiation [8]. PTPRB is glycosylated protein (phosphacan).
PTPRB mutations is observed in cancers. Its mutations are recurrent in angiosarcoma [9]. PTPRB mediates glial tumor cell adhesion by binding to tenascin C [10].
PTPRB interacts with neuronal receptors and promotes neurite outgrowth [11].
References
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Error fetching PMID 19116766:
- Error fetching PMID 20301196:
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- Error fetching PMID 10557082:
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