Difference between revisions of "Phosphatase Subfamily PTPN1"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[ | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]] |
| − | + | The PTPN1 subfamily dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). | |
| + | |||
| + | ===Evolution=== | ||
| + | PTPN1 subfamily emerged in animals, as it is found in most if not all eumetazoa, Porifera (e.g. sponge) and Placozoa (e.g. Trichoplax), but absent from Choanoflagellata (e.g. Monosiga) (for the phylogeny of animal at [http://en.wikipedia.org/wiki/Animal#Ctenophora.2C_Porifera.2C_Placozoa.2C_Cnidaria_and_Bilateria here]). In human, there are two copies: [[Phosphatase_Gene_PTPN1|PTPN1 (PTP1B)]] and [[Phosphatase_Gene_PTPN2|PTPN2 (TCPTP)]]. The two copies can be traced back to the time when vertebrates emerged. The orthologs for each of them are found in most vertebrates from fish to primates, and there is a single copy in non-vertebrate metazoa. | ||
| + | |||
| + | ===Domain === | ||
| + | The PTPN1 subfamily has a single structural domain, phosphatase domain. | ||
| + | |||
| + | ===Functions=== | ||
| + | The PTPN1 subfamily has various functions <cite>Zabolotny02, Tonks03, Zhang07, Tiganis13</cite>. It dephoshorylates kinases of various families, such as Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2): | ||
| + | |||
| + | ===== Human PTPN1 (PTPB1) ===== | ||
| + | ====== Substrates ====== | ||
| + | * BRK. PTPN1 (PTP1B) inhibited BRK, a member of SRM subfamily, SRC family, by directly dephosphorylating the Tyr-342 autophosphorylation site <cite>Fan15</cite>. | ||
| + | |||
| + | ====== Other functions and regulatory mechanisms ====== | ||
| + | * Human PTPN1 (PTPB1) is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>. | ||
| + | * Human PTPN1 (PTPB1) plays a key role in regulating dendritic cell maturation, migration and T cell activation <cite>Martin-Granados15</cite>. | ||
| + | * Humant PTPN1 (PTB1) is involved in the regulation of blood brain barrier endothelial permeability <cite>Siddiqui15</cite>. | ||
| + | |||
| + | ===== Human PTPN2 ===== | ||
| + | ====== Substrates ====== | ||
| + | * STAT3. PTPN2 (TCPTP) interacts with, dephosphorylates and inactivates STAT3. The activity is enhanced by STAT3-Interacting Protein As a Repressor (SIPAR) <cite>Ren15</cite>. | ||
| + | |||
| + | |||
| + | ===References=== | ||
| + | <biblio> | ||
| + | #Barrett99 pmid=10350489 | ||
| + | #Fan15 pmid=25897081 | ||
| + | #Martin-Granados15 pmid=26063615 | ||
| + | #Ren15 pmid=26026268 | ||
| + | #Siddiqui15 pmid=26090670 | ||
| + | #Tiganis13 pmid=22404968 | ||
| + | #Tonks03 pmid=12829250 | ||
| + | #Zabolotny02 pmid=11970898 | ||
| + | #Zhang07 pmid=17467573 | ||
| + | </biblio> | ||
Latest revision as of 16:06, 22 June 2015
Phosphatase Classification: Fold CC1:Superfamily CC1: Family PTP: Subfamily PTPN1
The PTPN1 subfamily dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2).
Contents
Evolution
PTPN1 subfamily emerged in animals, as it is found in most if not all eumetazoa, Porifera (e.g. sponge) and Placozoa (e.g. Trichoplax), but absent from Choanoflagellata (e.g. Monosiga) (for the phylogeny of animal at here). In human, there are two copies: PTPN1 (PTP1B) and PTPN2 (TCPTP). The two copies can be traced back to the time when vertebrates emerged. The orthologs for each of them are found in most vertebrates from fish to primates, and there is a single copy in non-vertebrate metazoa.
Domain
The PTPN1 subfamily has a single structural domain, phosphatase domain.
Functions
The PTPN1 subfamily has various functions [1, 2, 3, 4]. It dephoshorylates kinases of various families, such as Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2):
Human PTPN1 (PTPB1)
Substrates
- BRK. PTPN1 (PTP1B) inhibited BRK, a member of SRM subfamily, SRC family, by directly dephosphorylating the Tyr-342 autophosphorylation site [5].
Other functions and regulatory mechanisms
- Human PTPN1 (PTPB1) is regulated via glutathionylation of cysteine at the catalytic motif Cx5R [6].
- Human PTPN1 (PTPB1) plays a key role in regulating dendritic cell maturation, migration and T cell activation [7].
- Humant PTPN1 (PTB1) is involved in the regulation of blood brain barrier endothelial permeability [8].
Human PTPN2
Substrates
- STAT3. PTPN2 (TCPTP) interacts with, dephosphorylates and inactivates STAT3. The activity is enhanced by STAT3-Interacting Protein As a Repressor (SIPAR) [9].
References
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