Difference between revisions of "Phosphatase Superfamily HAD"
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| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]] | ||
| − | + | === Families === | |
| + | The HAD (HaloAcid Dehalogenase) superfamily contains many different hydrolase enzymes, including three with reported protein phosphatase activity <cite>Koonin, Burroughs</cite>: | ||
| + | * '''[[Phosphatase_Family_EYA|EYA family]]''' | ||
| − | + | * '''[[Phosphatase_Family_FCP|FCP family]]''' | |
| − | '''[[ | + | * '''[[Phosphatase_Family_NagD|NagD family]]''' |
| − | + | Note: The [[Phosphatase_Family_MDP1|MDP1 family]] has been removed from the protein phosphatome, because it has been confirmed as a protein-fructosamine-6-phosphatase. | |
| − | + | === Unclassifed HADs === | |
| + | * Yeast SER2 is a putative protein serine phosphatase <cite>Kuznetsova15</cite>. It does not belong to any family above. | ||
| − | + | === References === | |
| − | + | ||
| − | == References == | + | |
<biblio> | <biblio> | ||
#Burroughs pmid=16889794 | #Burroughs pmid=16889794 | ||
#Koonin pmid=7966317 | #Koonin pmid=7966317 | ||
| + | #Kuznetsova15 pmid=26071590 | ||
</biblio> | </biblio> | ||
Latest revision as of 04:40, 9 May 2016
Phosphatase Classification: Fold HAD: Superfamily HAD
Families
The HAD (HaloAcid Dehalogenase) superfamily contains many different hydrolase enzymes, including three with reported protein phosphatase activity [1, 2]:
Note: The MDP1 family has been removed from the protein phosphatome, because it has been confirmed as a protein-fructosamine-6-phosphatase.
Unclassifed HADs
- Yeast SER2 is a putative protein serine phosphatase [3]. It does not belong to any family above.
References
- Koonin EV and Tatusov RL. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J Mol Biol. 1994 Nov 18;244(1):125-32. DOI:10.1006/jmbi.1994.1711 |
- Burroughs AM, Allen KN, Dunaway-Mariano D, and Aravind L. Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol. 2006 Sep 1;361(5):1003-34. DOI:10.1016/j.jmb.2006.06.049 |
- Kuznetsova E, Nocek B, Brown G, Makarova KS, Flick R, Wolf YI, Khusnutdinova A, Evdokimova E, Jin K, Tan K, Hanson AD, Hasnain G, Zallot R, de Crécy-Lagard V, Babu M, Savchenko A, Joachimiak A, Edwards AM, Koonin EV, and Yakunin AF. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. J Biol Chem. 2015 Jul 24;290(30):18678-98. DOI:10.1074/jbc.M115.657916 |
