Difference between revisions of "Phosphatase Gene PTPN1"
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=== Functions === | === Functions === | ||
| − | + | PTPN1 is perhaps the best understood classical PTP. It is a critical negative regulator of insulin and leptin signaling, as well as other receptor tyrosine kinases and cytokine receptors, and is known to undergo reversible oxidation (see review <cite>Feldhammer13</cite>). Recently, it has been reported that inactivation of PTP1B by reactive oxygen species is essential for oncogene-induced senescence (OIS), which prevents the progression of preneoplastic cells harboring oncogenic mutations <cite>yang14</cite>. | |
=== References === | === References === | ||
Revision as of 21:14, 17 December 2014
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPN1: Gene PTPN1
Evolution
See evolution section on page of Subfamily PTPN1.
Functions
PTPN1 is perhaps the best understood classical PTP. It is a critical negative regulator of insulin and leptin signaling, as well as other receptor tyrosine kinases and cytokine receptors, and is known to undergo reversible oxidation (see review [1]). Recently, it has been reported that inactivation of PTP1B by reactive oxygen species is essential for oncogene-induced senescence (OIS), which prevents the progression of preneoplastic cells harboring oncogenic mutations [2].
