Difference between revisions of "Phosphatase Subfamily PTPRB"
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===== PTPRB (VE-PTP) ===== | ===== PTPRB (VE-PTP) ===== | ||
| − | PTPRB is glycosylated (phosphacan). | + | PTPRB is also named vascular endothelial protein tyrosine phosphatase (VE-PTP). It is glycosylated (phosphacan). |
| + | |||
| + | PTPRB binds to VE-cadherin through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation <cite>Nawroth02</cite>. | ||
PTPRB interacts with neuronal receptors and promotes neurite outgrowth <cite>Garwood03</cite>. | PTPRB interacts with neuronal receptors and promotes neurite outgrowth <cite>Garwood03</cite>. | ||
| + | |||
| + | PTPRB mediate glial tumor cell adhesion by binding to [http://en.wikipedia.org/wiki/Tenascin_C#Role_in_cancer tenascin C] <cite>Adamsky01</cite>. | ||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
| + | #Adamsky01 pmid=11313993 | ||
#Garwood03 pmid=12700241 | #Garwood03 pmid=12700241 | ||
| + | #Nawroth02 pmid=12234928 | ||
</biblio> | </biblio> | ||
Revision as of 01:15, 25 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
Functions
(summary)
PTPRB (VE-PTP)
PTPRB is also named vascular endothelial protein tyrosine phosphatase (VE-PTP). It is glycosylated (phosphacan).
PTPRB binds to VE-cadherin through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation [1].
PTPRB interacts with neuronal receptors and promotes neurite outgrowth [2].
PTPRB mediate glial tumor cell adhesion by binding to tenascin C [3].
References
Error fetching PMID 12700241:
Error fetching PMID 12234928:
- Error fetching PMID 12234928:
- Error fetching PMID 12700241:
- Error fetching PMID 11313993:
