Difference between revisions of "Phosphatase Subfamily PTPRB"
(→PTPRB (VE-PTP)) |
(→Functions) |
||
| Line 25: | Line 25: | ||
PTPRB interacts with neuronal receptors and promotes neurite outgrowth <cite>Garwood03</cite>. | PTPRB interacts with neuronal receptors and promotes neurite outgrowth <cite>Garwood03</cite>. | ||
| + | |||
| + | |||
| + | ====== PTPRQ ====== | ||
===References=== | ===References=== | ||
Revision as of 04:22, 25 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
Functions
(summary)
PTPRB (VE-PTP)
PTPRB, a.k.a. vascular endothelial protein tyrosine phosphatase (VE-PTP), is expressed specifically in endothelial cells and regulates the spreading and migration of endothelial cells during angiogenesis [1]. PTPRB binds to vascular E-cadherin (VE-cadherin) through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation [2]. PTPRB associates with endothelial cell (EC)-selective receptor tyrosine kinase Tie2, which maintains vascular integrity [3, 4, 5, 6]. PTPRB regulates vascular endothelial growth factor receptor 2 activity thereby modulating the VEGF-response during angiogenesis [7].
PTPRB is intrinsically active and its inactivation is dependent on its ligand pleiotrophin (PTN) which is a platelet-derived growth factor-inducible, 18-kDa heparin-binding cytokine that signals diverse phenotypes in normal and deregulated cellular growth and differentiation [8]. PTPRB is glycosylated protein (phosphacan).
PTPRB mutations are observed in cancers. Its mutations are recurrent in angiosarcoma [9]. PTPRB mediates glial tumor cell adhesion by binding to tenascin C [10].
PTPRB interacts with neuronal receptors and promotes neurite outgrowth [11].
PTPRQ
References
Error fetching PMID 24633157:
Error fetching PMID 10557082:
Error fetching PMID 12700241:
Error fetching PMID 19136612:
Error fetching PMID 10706604:
Error fetching PMID 20301196:
Error fetching PMID 12234928:
Error fetching PMID 25180601:
Error fetching PMID 19451274:
Error fetching PMID 19116766:
- Error fetching PMID 20301196:
- Error fetching PMID 12234928:
- Error fetching PMID 10557082:
- Error fetching PMID 19451274:
- Error fetching PMID 19116766:
- Error fetching PMID 25180601:
- Error fetching PMID 19136612:
- Error fetching PMID 10706604:
- Error fetching PMID 24633157:
- Error fetching PMID 11313993:
- Error fetching PMID 12700241:
