Difference between revisions of "Phosphatase Family NagD"
From PhosphataseWiki
| Line 3: | Line 3: | ||
The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies: | The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies: | ||
| − | * [[Phosphatase_Subfamily_PGP|PGP]] | + | * [[Phosphatase_Subfamily_PGP|PGP]] is a ubiquitous HAD subfamily in eukaryotes. The two members in human have distinct functions: PDXP (aka chronophin) dephosphorylates protein cofilin on serine residue, as well as pyridoxal 5'-phosphate; PGP is a putative tyrosine-specific protein phosphatase. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues. |
* [[Phosphatase_Subfamily_LHPP|LHPP]] is a protein histidine phosphatase subfamily conserved in holozoan. | * [[Phosphatase_Subfamily_LHPP|LHPP]] is a protein histidine phosphatase subfamily conserved in holozoan. | ||
* [[Phosphatase_Subfamily_CUT|CUT]] - no strong evidence supports it has protein phosphatase activity. | * [[Phosphatase_Subfamily_CUT|CUT]] - no strong evidence supports it has protein phosphatase activity. | ||
Revision as of 18:44, 9 March 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD
The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:
- PGP is a ubiquitous HAD subfamily in eukaryotes. The two members in human have distinct functions: PDXP (aka chronophin) dephosphorylates protein cofilin on serine residue, as well as pyridoxal 5'-phosphate; PGP is a putative tyrosine-specific protein phosphatase. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.
- LHPP is a protein histidine phosphatase subfamily conserved in holozoan.
- CUT - no strong evidence supports it has protein phosphatase activity.
