Difference between revisions of "Phosphatase Subfamily PTPRB"

Revision as of 00:37, 25 February 2015

Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB

PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.

Evolution

PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.

Domain Structure

PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.

Functions

CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.

References

1. Error fetching PMID 25128530: [furlan14]