Difference between revisions of "Phosphatase Subfamily CUT"
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| − | Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase | + | Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129). |
=== References === | === References === | ||
Revision as of 01:02, 22 March 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily CUT
Cut genes are related to other eukaryotic NagD phosphatases, but have not been shown to have protein phosphatase activity.
Evolution
This family is present throughout eukaryotes, mostly single-copy but with several duplications. It is lost from Drosophila but present in other arthropods.
Domain
CUT has a single domain, HAD domain.
Function
Cut proteins are localized to the mitochondria [1, 2]. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase [3] and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress [4]. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
References
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