Difference between revisions of "Phosphatase Subfamily PTPN1"
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| − | + | __NOTOC__ | |
| − | PTPN1 | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]] |
| − | + | The PTPN1 subfamily dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). | |
| − | PTPN1 subfamily | + | |
| − | + | ===Evolution=== | |
| + | PTPN1 subfamily emerged in animals, as it is found in most if not all eumetazoa, Porifera (e.g. sponge) and Placozoa (e.g. Trichoplax), but absent from Choanoflagellata (e.g. Monosiga) (for the phylogeny of animal at [http://en.wikipedia.org/wiki/Animal#Ctenophora.2C_Porifera.2C_Placozoa.2C_Cnidaria_and_Bilateria here]). In human, there are two copies: [[Phosphatase_Gene_PTPN1|PTPN1 (PTP1B)]] and [[Phosphatase_Gene_PTPN2|PTPN2 (TCPTP)]]. The two copies can be traced back to the time when vertebrates emerged. The orthologs for each of them are found in most vertebrates from fish to primates, and there is a single copy in non-vertebrate metazoa. | ||
| − | + | ===Domain === | |
| + | The PTPN1 subfamily has a single structural domain, phosphatase domain. | ||
| + | |||
| + | ===Functions=== | ||
| + | The PTPN1 subfamily has various functions <cite>Zabolotny02, Tonks03, Zhang07, Tiganis13</cite>. It dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). | ||
| + | |||
| + | PTPN1 is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>. | ||
| + | |||
| + | ===References=== | ||
| + | <biblio> | ||
| + | #Barrett99 pmid=10350489 | ||
| + | #Tiganis13 pmid=22404968 | ||
| + | #Tonks03 pmid=12829250 | ||
| + | #Zabolotny02 pmid=11970898 | ||
| + | #Zhang07 pmid=17467573 | ||
| + | </biblio> | ||
Revision as of 23:49, 24 March 2015
Phosphatase Classification: Fold CC1:Superfamily CC1: Family PTP: Subfamily PTPN1
The PTPN1 subfamily dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2).
Evolution
PTPN1 subfamily emerged in animals, as it is found in most if not all eumetazoa, Porifera (e.g. sponge) and Placozoa (e.g. Trichoplax), but absent from Choanoflagellata (e.g. Monosiga) (for the phylogeny of animal at here). In human, there are two copies: PTPN1 (PTP1B) and PTPN2 (TCPTP). The two copies can be traced back to the time when vertebrates emerged. The orthologs for each of them are found in most vertebrates from fish to primates, and there is a single copy in non-vertebrate metazoa.
Domain
The PTPN1 subfamily has a single structural domain, phosphatase domain.
Functions
The PTPN1 subfamily has various functions [1, 2, 3, 4]. It dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2).
PTPN1 is regulated via glutathionylation of cysteine at the catalytic motif Cx5R [5].
References
Error fetching PMID 22404968:
Error fetching PMID 12829250:
Error fetching PMID 11970898:
Error fetching PMID 17467573:
- Error fetching PMID 11970898:
- Error fetching PMID 12829250:
- Error fetching PMID 17467573:
- Error fetching PMID 22404968:
- Error fetching PMID 10350489:
