Difference between revisions of "Phosphatase Superfamily HAD"

Revision as of 18:12, 14 March 2014

Phosphatase Classification: HAD

The HAD (HaloAcid Dehalogenase) superfamily contains an array of different hydrolase enzymes, including several that are known to have protein phosphatase or other phosphatase activites [1, 2]. The following HAD families have reported protein phosphatase activity:

EYA (Eyes Absent)

FCP

NagD

MDP1

References

1. Koonin EV and Tatusov RL. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J Mol Biol. 1994 Nov 18;244(1):125-32. DOI:10.1006/jmbi.1994.1711 | PubMed ID:7966317 | HubMed [Koonin]
2. Burroughs AM, Allen KN, Dunaway-Mariano D, and Aravind L. Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol. 2006 Sep 1;361(5):1003-34. DOI:10.1016/j.jmb.2006.06.049 | PubMed ID:16889794 | HubMed [Burroughs]