Difference between revisions of "Phosphatase Subfamily MTMR10"
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===Evolution=== | ===Evolution=== | ||
| − | MTMR10 is found in most metazoa. | + | MTMR10 is found in most metazoa. Humans have 3 genes: MTMR10, MTMR11, MTMR12. |
===Domain Structure=== | ===Domain Structure=== | ||
Revision as of 21:16, 8 September 2016
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR10
MTMR10 is a conserved pseudophosphatase in metazoa. Its molecular function is unclear.
Evolution
MTMR10 is found in most metazoa. Humans have 3 genes: MTMR10, MTMR11, MTMR12.
Domain Structure
MTMR10 subfamily has three domains: GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar in structure to the PH domain and is found in membrane-associated proteins.
Two of the three sponge MTMR10s have a Death domain and a DUF3584 domain flanking the phosphatase domains. Death domains bind each other forming oligomers. DUF3584 is close to AAA+ superfamily. They do not have a GRAM or coiled-coil domain. The third sponge member is a fragment copy of one of the other two.
Catalytic activity and functions
MTMR10 is an inactive phosphatase (pseudophosphatase), but its function is unclear. Other pseudophosphatases within myotubularin family (Subfamily MTMR5 and Subfamily MTMR9) regulate active myotubularins via protein interactions mediated by coiled coils. It interacts with MTM1 and MTMR1 of MTMR1 subfamily [1].
References
- Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, and Mitchell CA. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8660-5. DOI:10.1073/pnas.1033097100 |
