Phosphatase Subfamily PTPRB
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
Functions
(summary)
PTPRB (VE-PTP)
PTPRB is also named vascular endothelial protein tyrosine phosphatase (VE-PTP). It is glycosylated (phosphacan).
PTPRB binds to VE-cadherin through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin. But, the reduction of tyrosine phosphorylation seems independently of its enzymatic activity, since catalytically inactive mutant form of PTPRB had the same effect on VE-cadherin phosphorylation [1].
PTPRB interacts with neuronal receptors and promotes neurite outgrowth [2].
PTPRB mediate glial tumor cell adhesion by binding to tenascin C [3].
References
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